Hmgcr (3-hydroxy-3-methylglutaryl-CoA reductase) - Rat Genome Database

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Gene: Hmgcr (3-hydroxy-3-methylglutaryl-CoA reductase) Rattus norvegicus
Symbol: Hmgcr
Name: 3-hydroxy-3-methylglutaryl-CoA reductase
RGD ID: 2803
Description: Enables identical protein binding activity and protein phosphatase 2A binding activity. Involved in several processes, including cholesterol homeostasis; positive regulation of MAPK cascade; and regulation of striated muscle cell apoptotic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane and peroxisomal membrane. Used to study Wilson disease; drug-induced hepatitis; end stage renal disease; pulmonary hypertension; and type 2 diabetes mellitus. Biomarker of chronic kidney disease; end stage renal disease; metabolic dysfunction-associated steatotic liver disease; and premature menopause. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; coronary artery disease (multiple); diabetes mellitus (multiple); muscular disease (multiple); and neurodegenerative disease (multiple). Orthologous to human HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase); PARTICIPATES IN bile acid signaling pathway; metabolic syndrome X pathway; alendronate pharmacodynamics pathway; INTERACTS WITH (25R)-cholest-5-ene-3beta,26-diol; (R,R,R)-alpha-tocopherol; (S)-nicotine.
Type: protein-coding
Previously known as: 3-hydroxy-3-methylglutaryl-coenzyme A reductase; 3H3M; HMG-CoA reductase
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8229,732,163 - 29,754,276 (-)NCBIGRCr8
mRatBN7.2227,997,523 - 28,018,983 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl227,997,525 - 28,019,703 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx235,045,191 - 35,066,504 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0233,145,271 - 33,166,584 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0227,959,454 - 27,980,761 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0227,480,224 - 27,500,654 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl227,480,226 - 27,500,654 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0246,592,881 - 46,614,276 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4227,127,504 - 27,149,580 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1227,047,872 - 27,069,949 (-)NCBI
Celera224,043,814 - 24,065,183 (-)NCBICelera
RH 3.4 Map213.3RGD
Cytogenetic Map2q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinic acid  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(24S)-24-hydroxycholesterol  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (EXP,ISO)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-nicotine  (EXP,ISO)
1,2,3-trilinolenoylglycerol  (ISO)
1,2,3-trilinoleoylglycerol  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
1,3,5-trinitro-1,3,5-triazinane  (EXP)
1,3-dichloropropan-2-ol  (ISO)
1,8-cineole  (ISO)
1-(3-(trifluoromethyl)phenyl)piperazine  (EXP)
1-benzylpiperazine  (EXP)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2'-Dihydroxy-4-methoxybenzophenone  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-D  (ISO)
2,4-dibromophenol  (ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2,6-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
2-trans,6-trans-farnesyl diphosphate  (ISO)
22-Hydroxycholesterol  (ISO)
24,25-dihydrolanosterol  (ISO)
25-hydroxycholesterol  (EXP,ISO)
26-hydroxycholesterol  (EXP,ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3beta-hydroxy-5alpha-cholest-8(14)-en-15-one  (ISO)
3beta-hydroxylanost-8-en-32-al  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxy-TEMPO  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-bromo-2'-deoxyuridine  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP)
6-propyl-2-thiouracil  (EXP)
7-ketocholesterol  (ISO)
7alpha-hydroxycholesterol  (EXP)
acetamide  (EXP)
acrylamide  (EXP,ISO)
Actein  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
alliin  (EXP,ISO)
alpha-naphthoflavone  (EXP)
amiodarone  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphotericin B  (ISO)
ampicillin  (ISO)
arachidonic acid  (ISO)
Archazolid B  (ISO)
Aroclor 1254  (EXP,ISO)
arsane  (ISO)
arsenic atom  (ISO)
atorvastatin calcium  (EXP,ISO)
avobenzone  (ISO)
Azaspiracid  (ISO)
azathioprine  (ISO)
benzalkonium chloride  (ISO)
benzene  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
benzofurans  (ISO)
beta-ionone  (EXP)
beta-naphthoflavone  (EXP,ISO)
betulin  (ISO)
bezafibrate  (EXP,ISO)
bilirubin IXalpha  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bucladesine  (ISO)
butan-1-ol  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
caffeine  (EXP,ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGS-21680  (ISO)
chenodeoxycholic acid  (EXP,ISO)
chitosan  (EXP)
chlorogenic acid  (EXP,ISO)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
cholesterol  (EXP,ISO)
cholic acid  (EXP)
choline  (ISO)
chromium atom  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clofibrate  (EXP,ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
colesevelam hydrochloride  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
corilagin  (EXP)
corn oil  (EXP)
cortisol  (ISO)
coumarin  (EXP)
crizotinib  (ISO)
crocidolite asbestos  (ISO)
curcumin  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
cyproconazole  (ISO)
D-gluconic acid  (EXP)
dehydroepiandrosterone  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
desmosterol  (ISO)
dexamethasone  (EXP,ISO)
Di-n-hexyl phthalate  (EXP)
Di-n-octyl phthalate  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
Dicyclohexyl phthalate  (EXP)
diethyl phthalate  (EXP,ISO)
diethylstilbestrol  (EXP)
difenoconazole  (EXP)
diisobutyl phthalate  (EXP)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (EXP,ISO)
dinophysistoxin 1  (ISO)
dioxygen  (ISO)
dipentyl phthalate  (EXP)
diquat  (ISO)
disodium selenite  (EXP,ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP)
elemental selenium  (EXP,ISO)
endosulfan  (EXP,ISO)
enilconazole  (ISO)
enniatin  (ISO)
entinostat  (ISO)
Epomediol  (EXP)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
eugenol  (ISO)
ezetimibe  (ISO)
farnesol  (EXP,ISO)
farnesyl diphosphate  (ISO)
fenarimol  (EXP)
fenofibrate  (EXP,ISO)
fentin chloride  (EXP)
fenvalerate  (EXP)
ferulic acid  (ISO)
fingolimod hydrochloride  (ISO)
fluoranthene  (ISO)
fluoxetine  (ISO)
flusilazole  (ISO)
flutamide  (EXP)
fluvastatin  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fructose  (EXP)
fucoxanthin  (ISO)
furan  (EXP,ISO)
Ganoderic acid A  (ISO)
genistein  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
geranyl diphosphate  (ISO)
geranylgeraniol  (ISO)
glafenine  (EXP)
glutathione  (EXP)
Glycidyl stearate  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (ISO)
GW 4064  (ISO)
GW 7647  (ISO)
haloperidol  (ISO)
Heptachlor epoxide  (ISO)
hesperidin  (ISO)
hexadecanoic acid  (ISO)
HT-2 toxin  (ISO)
hydrogen peroxide  (ISO)
hydroxychloroquine  (ISO)
imidacloprid  (ISO)
isobutanol  (ISO)
isoprenaline  (EXP)
isotretinoin  (ISO)
ketamine  (EXP)
ketoconazole  (EXP,ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lanost-8-ene-3beta,30-diol  (ISO)
lead diacetate  (EXP,ISO)
lead nitrate  (EXP,ISO)
lead(0)  (EXP)
lead(II) chloride  (ISO)
leflunomide  (EXP)
linalool  (ISO)
lipopolysaccharide  (EXP,ISO)
lithocholic acid  (ISO)
loperamide  (ISO)
losartan  (EXP)
lovastatin  (ISO)
m-xylene  (EXP)
magnesium atom  (EXP)
manganese atom  (EXP)
manganese(0)  (EXP)
menadione  (ISO)
mercury dichloride  (EXP)
metformin  (EXP,ISO)
methimazole  (EXP,ISO)
methyl methanesulfonate  (ISO)
metronidazole  (ISO)
mevalonic acid  (EXP,ISO)
mevalonolactone  (ISO)
miconazole  (ISO)
microcystin-LR  (ISO)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotophos  (EXP)
myricetin  (EXP)
N-acetyl-L-cysteine  (EXP)
N-methylformamide  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP,ISO)
naringin  (EXP,ISO)
nefazodone  (EXP)
neomycin  (ISO)
nickel dichloride  (ISO)
nicotinamide  (EXP)
nicotine  (EXP,ISO)
nimesulide  (EXP)
obeticholic acid  (ISO)
octocrylene  (ISO)
okadaic acid  (ISO)
olanzapine  (EXP,ISO)
oleic acid  (ISO)
orlistat  (EXP)
oxybenzone  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
perflubron  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (ISO)
phenformin  (EXP)
phenylmercury acetate  (ISO)
phenylpropanolamine  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phorone  (EXP)
phosphatidylcholine  (EXP)
phytosterols  (ISO)
picoxystrobin  (ISO)
pioglitazone  (ISO)
piperine  (EXP)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pravastatin  (EXP,ISO)
pregnenolone  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
proanthocyanidin  (EXP)
progesterone  (ISO)
propamocarb  (ISO)
propiconazole  (EXP,ISO)
puerarin  (EXP)
pyrethrins  (EXP)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
quinolin-8-ol  (ISO)
resveratrol  (EXP,ISO)
risperidone  (ISO)
rotenone  (EXP,ISO)
SB 431542  (ISO)
selenium atom  (EXP,ISO)
senecionine  (ISO)
silibinin  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium cholate  (ISO)
Soman  (EXP)
soybean oil  (EXP)
stigmasterol  (ISO)
streptozocin  (EXP,ISO)
sucrose  (EXP)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
T-2 toxin  (ISO)
tamoxifen  (ISO)
tebuconazole  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetracycline  (EXP)
tetrahydrocurcumin  (EXP)
thapsigargin  (EXP,ISO)
thiazolidinediones  (ISO)
thioacetamide  (EXP)
thiourea  (EXP)
titanium dioxide  (ISO)
trans-caffeic acid  (ISO)
trans-cinnamic acid  (ISO)
triacsin C  (ISO)
triadimefon  (EXP,ISO)
tributyl phosphate  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (EXP)
trimellitic anhydride  (ISO)
triolein  (ISO)
triphenyl phosphate  (EXP,ISO)
triphenylstannane  (EXP)
Triptolide  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
umbelliferone  (EXP)
undecane  (EXP)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
warfarin  (EXP)
Yessotoxin  (ISO)
zaragozic acid A  (EXP,ISO)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)
zingerone  (EXP)
ziprasidone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function


References - curated
# Reference Title Reference Citation
1. The HMG-CoA reductase inhibitor pravastatin stimulates insulin secretion through organic anion transporter polypeptides. Abe M, etal., Drug Metab Pharmacokinet. 2010;25(3):274-82.
2. Fermented rice bran supplementation mitigates metabolic syndrome in stroke-prone spontaneously hypertensive rats. Alauddin M, etal., BMC Complement Altern Med. 2016 Nov 8;16(1):442. doi: 10.1186/s12906-016-1427-z.
3. A rice bran oil diet increases LDL-receptor and HMG-CoA reductase mRNA expressions and insulin sensitivity in rats with streptozotocin/nicotinamide-induced type 2 diabetes. Chen CW and Cheng HH, J Nutr. 2006 Jun;136(6):1472-6.
4. Combination therapy with fenofibrate, a peroxisome proliferator-activated receptor alpha agonist, and simvastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor, on experimental traumatic brain injury. Chen XR, etal., J Pharmacol Exp Ther. 2008 Sep;326(3):966-74. Epub 2008 Jun 18.
5. Inhibition of mineralocorticoid receptor is a renoprotective effect of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor pitavastatin. Cheng XW, etal., J Hypertens. 2011 Mar;29(3):542-52.
6. Contribution of increased HMG-CoA reductase gene expression to hypercholesterolemia in experimental chronic renal failure. Chmielewski M, etal., Mol Cell Biochem 2003 Apr;246(1-2):187-91.
7. Protective effect of Codonopsis lanceolata root extract against alcoholic fatty liver in the rat. Cho K, etal., J Med Food. 2009 Dec;12(6):1293-301.
8. Niacin improves renal lipid metabolism and slows progression in chronic kidney disease. Cho KH, etal., Biochim Biophys Acta. 2010 Jan;1800(1):6-15. Epub 2009 Oct 28.
9. Impaired VLDL assembly: a novel mechanism contributing to hepatic lipid accumulation following ovariectomy and high-fat/high-cholesterol diets? Côté I, etal., Br J Nutr. 2014 Nov 28;112(10):1592-600. doi: 10.1017/S0007114514002517. Epub 2014 Sep 29.
10. An atherogenic diet decreases liver FXR gene expression and causes severe hepatic steatosis and hepatic cholesterol accumulation: effect of endurance training. Côté I, etal., Eur J Nutr. 2013 Aug;52(5):1523-32. doi: 10.1007/s00394-012-0459-5. Epub 2012 Nov 2.
11. Integrin expression on monocytes and lymphocytes in unstable angina short term effects of atorvastatin. Dobreanu M, etal., Rom J Intern Med. 2007;45(2):193-9.
12. Functional size of rat hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase as determined by radiation inactivation. Edwards PA, etal., J Biol Chem. 1985 Aug 25;260(18):10278-82.
13. Fluvastatin synergistically improves the antiproliferative effect of everolimus on rat smooth muscle cells by altering p27Kip1/cyclin E expression. Ferri N, etal., Mol Pharmacol. 2008 Jul;74(1):144-53. Epub 2008 Apr 15.
14. Blood-brain barrier permeability and monocyte infiltration in experimental allergic encephalomyelitis: a quantitative MRI study. Floris S, etal., Brain. 2004 Mar;127(Pt 3):616-27. Epub 2003 Dec 22.
15. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
16. Suppression of autoimmune retinal disease by lovastatin does not require Th2 cytokine induction. Gegg ME, etal., J Immunol. 2005 Feb 15;174(4):2327-35.
17. Attenuation of chronic hypoxic pulmonary hypertension by simvastatin. Girgis RE, etal., Am J Physiol Heart Circ Physiol. 2003 Sep;285(3):H938-45. Epub 2003 May 15.
18. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
19. Differential binding of proteins to peroxisomes in rat hepatoma cells: unique association of enzymes involved in isoprenoid metabolism. Gupta SD, etal., J Lipid Res. 1999 Sep;40(9):1572-84.
20. Inflammatory markers in nondiabetic and diabetic rat retinas exposed to ischemia followed by reperfusion. Gustavsson C, etal., Retina. 2008 Apr;28(4):645-52.
21. Pre-germinated brown rice extract ameliorates high-fat diet-induced metabolic syndrome. Hao CL, etal., J Food Biochem. 2019 Mar;43(3):e12769. doi: 10.1111/jfbc.12769. Epub 2019 Jan 13.
22. Simvastatin improves wound strength after intestinal anastomosis in the rat. Karadeniz Cakmak G, etal., J Gastrointest Surg. 2009 Sep;13(9):1707-16. Epub 2009 Jul 4.
23. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
24. Post-ischemic delivery of the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor rosuvastatin protects against focal cerebral ischemia in mice via inhibition of extracellular-regulated kinase-1/-2. Kilic U, etal., Neuroscience. 2005;134(3):901-6.
25. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
26. Abnormal hepatobiliary and circulating lipid metabolism in the Long-Evans Cinnamon rat model of Wilson's disease. Levy E, etal., Life Sci. 2007 Mar 27;80(16):1472-83. Epub 2007 Jan 20.
27. Statin therapy is associated with reduced neuropathologic changes of Alzheimer disease. Li G, etal., Neurology. 2007 Aug 28;69(9):878-85.
28. The effect of statins on mortality in patients with bacteremia. Liappis AP, etal., Clin Infect Dis. 2001 Oct 15;33(8):1352-7. Epub 2001 Sep 20.
29. Mutation burden analysis of six common mental disorders in African Americans by whole genome sequencing. Liu Y, etal., Hum Mol Genet. 2022 Nov 10;31(22):3769-3776. doi: 10.1093/hmg/ddac129.
30. Autoantibodies against 3-hydroxy-3-methylglutaryl-coenzyme A reductase in patients with statin-associated autoimmune myopathy. Mammen AL, etal., Arthritis Rheum. 2011 Mar;63(3):713-21. doi: 10.1002/art.30156.
31. Adverse effects of long-term exposure to bisphenol A during adulthood leading to hyperglycaemia and hypercholesterolemia in mice. Marmugi A, etal., Toxicology. 2014 Nov 5;325:133-43. doi: 10.1016/j.tox.2014.08.006. Epub 2014 Aug 26.
32. 3-hydroxy 3-methylglutaryl coenzyme A reductase increase is essential for rat muscle differentiation. Martini C, etal., J Cell Physiol. 2009 Aug;220(2):524-30.
33. Comparison of the short-term efficacy and tolerability of lovastatin and pravastatin in the management of primary hypercholesterolemia. McPherson R, etal., Clin Ther. 1992 Mar-Apr;14(2):276-91.
34. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
35. 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor Atorvastatin mediated effects depend on the activation status of target cells in PLP-EAE. Mix E, etal., J Autoimmun. 2006 Dec;27(4):251-65. Epub 2006 Nov 3.
36. Simvastatin inhibits leukocyte accumulation and vascular permeability in the retinas of rats with streptozotocin-induced diabetes. Miyahara S, etal., Am J Pathol. 2004 May;164(5):1697-706.
37. Effects of combined olmesartan and pravastatin on glucose intolerance and cardiovascular remodeling in a metabolic-syndrome model. Mizukawa M, etal., Hypertens Res. 2009 Jul;32(7):617-24. Epub 2009 May 22.
38. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
39. Pharmacokinetic comparison of the potential over-the-counter statins simvastatin, lovastatin, fluvastatin and pravastatin. Neuvonen PJ, etal., Clin Pharmacokinet. 2008;47(7):463-74.
40. LDL receptor and Pcsk9 transcripts are decreased in liver of ovariectomized rats: effects of exercise training. Ngo Sock ET, etal., Horm Metab Res. 2014 Jul;46(8):550-5. doi: 10.1055/s-0034-1370910. Epub 2014 Mar 11.
41. Synergistic action of statins and nitrogen-containing bisphosphonates in the development of rhabdomyolysis in L6 rat skeletal myoblasts. Nishiguchi T, etal., J Pharm Pharmacol. 2009 Jun;61(6):781-8.
42. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
43. The effect of statin therapy on allergic patients with asthma. Ostroukhova M, etal., Ann Allergy Asthma Immunol. 2009 Dec;103(6):463-8.
44. Rat HMGCoA reductase activation in thioacetamide-induced liver injury is related to an increased reactive oxygen species content. Pallottini V, etal., J Hepatol. 2006 Feb;44(2):368-74. Epub 2005 Jul 11.
45. Mechanisms underlying the impaired regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in aged rat liver. Pallottini V, etal., Mech Ageing Dev. 2004 Sep;125(9):633-9.
46. Age-related HMG-CoA reductase deregulation depends on ROS-induced p38 activation. Pallottini V, etal., Mech Ageing Dev. 2007 Nov-Dec;128(11-12):688-95. Epub 2007 Oct 16.
47. Expression of cholesterol homeostasis genes in the brain of the male rat is affected by age and dietary restriction. Perovic M, etal., Biogerontology. 2009 Mar 7.
48. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
49. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
50. Reduced incidence of new-onset diabetes mellitus after renal transplantation with 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors (statins). Prasad GV, etal., Am J Transplant. 2004 Nov;4(11):1897-903.
51. GOA pipeline RGD automated data pipeline
52. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
53. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
54. Effect of HMG-CoA reductase inhibitors on proliferation and protein synthesis by rat hepatic stellate cells. Rombouts K, etal., J Hepatol. 2003 May;38(5):564-72.
55. Progesterone-receptor antagonists and statins decrease de novo cholesterol synthesis and increase apoptosis in rat and human periovulatory granulosa cells in vitro. Rung E, etal., Biol Reprod. 2005 Mar;72(3):538-45. Epub 2004 Sep 22.
56. Lovastatin attenuates nerve injury in an animal model of Guillain-Barre syndrome. Sarkey JP, etal., J Neurochem. 2007 Mar;100(5):1265-77. Epub 2006 Dec 22.
57. White blood cell count predicts reduction in coronary heart disease mortality with pravastatin. Stewart RA, etal., Circulation. 2005 Apr 12;111(14):1756-62. Epub 2005 Apr 4.
58. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
59. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
60. Atorvastatin restores endothelial function in offspring of protein-restricted rats in a cholesterol-independent manner. Torrens C, etal., Hypertension. 2009 Apr;53(4):661-7. Epub 2009 Feb 16.
61. Mechanism underlying long-term regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase during L6 myoblast differentiation. Trapani L, etal., J Cell Biochem. 2010 May 15;110(2):392-8.
62. Effects of statin treatment and withdrawal on angiotensin II-induced phosphorylation of p38 MAPK and ERK1/2 in cultured vascular smooth muscle cells. Tristano AG, etal., Biochem Biophys Res Commun. 2007 Feb 2;353(1):11-7. Epub 2006 Nov 17.
63. Rosuvastatin, a new generation 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, reduces ischemia/reperfusion-induced spinal cord tissue injury in rats. Ucak A, etal., Ann Vasc Surg. 2011 Jul;25(5):686-95.
64. Progressive dysfunction of the cholesterol biosynthesis pathway in the R6/2 mouse model of Huntington's disease. Valenza M, etal., Neurobiol Dis. 2007 Oct;28(1):133-42. Epub 2007 Jul 10.
65. Ameliorative effect of Chlorophytum borivilianum root on lipid metabolism in hyperlipaemic rats. Visavadiya NP and Narasimhacharya AV, Clin Exp Pharmacol Physiol. 2007 Mar;34(3):244-9.
66. Hydroxymethylglutaryl coenzyme a reductase inhibitors down-regulate chemokines and chemokine receptors in patients with coronary artery disease. Waehre T, etal., J Am Coll Cardiol. 2003 May 7;41(9):1460-7.
67. Statin use and the risk of Parkinson disease. Wahner AD, etal., Neurology. 2008 Apr 15;70(16 Pt 2):1418-22. Epub 2008 Jan 9.
68. Defects of cholesterol biosynthesis. Waterham HR FEBS Lett. 2006 Oct 9;580(23):5442-9. Epub 2006 Jul 20.
69. Simvastatin is associated with a reduced incidence of dementia and Parkinson's disease. Wolozin B, etal., BMC Med. 2007 Jul 19;5:20.
70. Resveratrol inhibits the mevalonate pathway and potentiates the antiproliferative effects of simvastatin in rat theca-interstitial cells. Wong DH, etal., Fertil Steril. 2011 Sep 9.
71. Analysis of transcriptome and metabolome profiles alterations in fatty liver induced by high-fat diet in rat. Xie Z, etal., Metabolism. 2010 Apr;59(4):554-60. Epub 2009 Nov 14.
72. Synergism of simvastatin with losartan prevents angiotensin II-induced cardiomyocyte apoptosis in vitro. Xu J, etal., J Pharm Pharmacol. 2009 Apr;61(4):503-10.
73. Effects of pravastatin in murine collagen-induced arthritis. Yamagata T, etal., Rheumatol Int. 2007 May;27(7):631-9. Epub 2006 Nov 21.
74. Influence of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on ubiquinone levels in rat skeletal muscle and heart: relationship to cytotoxicity and inhibitory activity for cholesterol synthesis in human skeletal muscle cells. Yamazaki H, etal., J Atheroscler Thromb. 2006 Dec;13(6):295-307.
75. Protective effects of pravastatin in murine lipopolysaccharide-induced acute lung injury. Yao HW, etal., Clin Exp Pharmacol Physiol. 2006 Sep;33(9):793-7.
76. Simvastatin improves sepsis-induced mortality and acute kidney injury via renal vascular effects. Yasuda H, etal., Kidney Int. 2006 May;69(9):1535-42.
77. Effect of ScrF I polymorphism in the 2nd intron of the HMGCR gene on lipid-lowering response to simvastatin in Chinese diabetic patients. Ying S, etal., Biochem Biophys Res Commun. 2007 Nov 16;363(2):395-8. Epub 2007 Sep 10.
78. Effects of pravastatin on progression of glucose intolerance and cardiovascular remodeling in a type II diabetes model. Yu Y, etal., J Am Coll Cardiol. 2004 Aug 18;44(4):904-13.
79. Multitargeted effects of statin-enhanced thrombolytic therapy for stroke with recombinant human tissue-type plasminogen activator in the rat. Zhang L, etal., Circulation. 2005 Nov 29;112(22):3486-94.
Additional References at PubMed
PMID:1352323   PMID:1628744   PMID:2369897   PMID:2991281   PMID:7798939   PMID:8647961   PMID:9186920   PMID:10698924   PMID:11792727   PMID:12114517   PMID:12409258   PMID:12920113  
PMID:15090540   PMID:15337832   PMID:15489334   PMID:15845870   PMID:15919082   PMID:16100574   PMID:16636304   PMID:16741953   PMID:17180682   PMID:17327468   PMID:19470373   PMID:19895880  
PMID:20435455   PMID:20876579   PMID:22405826   PMID:22871113   PMID:23063590   PMID:23280554   PMID:23617777   PMID:24319730   PMID:24694611   PMID:28938515   PMID:33412161   PMID:34081950  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8229,732,163 - 29,754,276 (-)NCBIGRCr8
mRatBN7.2227,997,523 - 28,018,983 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl227,997,525 - 28,019,703 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx235,045,191 - 35,066,504 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0233,145,271 - 33,166,584 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0227,959,454 - 27,980,761 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0227,480,224 - 27,500,654 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl227,480,226 - 27,500,654 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0246,592,881 - 46,614,276 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4227,127,504 - 27,149,580 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1227,047,872 - 27,069,949 (-)NCBI
Celera224,043,814 - 24,065,183 (-)NCBICelera
RH 3.4 Map213.3RGD
Cytogenetic Map2q12NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38575,336,529 - 75,362,116 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl575,336,329 - 75,364,001 (+)EnsemblGRCh38hg38GRCh38
GRCh37574,632,993 - 74,657,941 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36574,668,855 - 74,693,681 (+)NCBINCBI36Build 36hg18NCBI36
Build 34574,668,854 - 74,693,681NCBI
Celera570,526,169 - 70,551,102 (+)NCBICelera
Cytogenetic Map5q13.3NCBI
HuRef569,838,165 - 69,863,098 (+)NCBIHuRef
CHM1_1574,065,715 - 74,090,648 (+)NCBICHM1_1
T2T-CHM13v2.0575,817,189 - 75,843,009 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391396,785,470 - 96,807,444 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1396,785,475 - 96,807,444 (-)EnsemblGRCm39 Ensembl
GRCm381396,648,962 - 96,670,936 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1396,648,967 - 96,670,936 (-)EnsemblGRCm38mm10GRCm38
MGSCv371397,418,917 - 97,440,891 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361397,750,033 - 97,771,547 (-)NCBIMGSCv36mm8
Celera13100,288,206 - 100,310,264 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1350.65NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495542525,359,884 - 25,380,745 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542525,362,165 - 25,380,611 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v2439,937,829 - 39,962,461 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1538,091,460 - 38,116,092 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0539,936,630 - 39,961,519 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1540,548,919 - 40,573,785 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl540,548,919 - 40,573,785 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1330,970,037 - 30,988,987 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl330,970,037 - 30,990,294 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha332,211,759 - 32,233,728 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0330,898,455 - 30,920,631 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl330,898,248 - 30,921,069 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1330,828,548 - 30,850,686 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0330,798,860 - 30,820,987 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0331,177,224 - 31,199,407 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024407213189,458,452 - 189,480,240 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365491,378,736 - 1,400,532 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365491,378,536 - 1,400,501 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl284,380,224 - 84,402,957 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1284,380,245 - 84,401,117 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2285,967,367 - 85,988,242 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap2q22NCBI
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1469,664,784 - 69,690,343 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl469,665,417 - 69,688,686 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604918,450,156 - 18,475,169 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_004624951682,178 - 711,474 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624951681,559 - 711,476 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Hmgcr
139 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:191
Count of miRNA genes:143
Interacting mature miRNAs:152
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631682Bp115Blood pressure QTL 1154.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2137410502Rat
738010Lnnr3Liver neoplastic nodule remodeling QTL 32.94liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)2141244106Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
1600379Mcs18Mammary carcinoma susceptibility QTL 182.6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2788777242804738Rat
738012Anxrr3Anxiety related response QTL 33.8exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)2902351954023519Rat
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)21185206249003364Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat
10402051Gdil2Gastrointestinal dilation QTL 2enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)22490385374786777Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22691781781754745Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
1331764Bp205Blood pressure QTL 2053.476arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)22699957143154682Rat
1643006Pain1Pain QTL 13.630.005mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)22699957148268661Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22715716072157160Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2227,997,953 - 27,998,133 (+)MAPPERmRatBN7.2
Rnor_6.0227,480,655 - 27,480,834NCBIRnor6.0
Rnor_5.0246,593,312 - 46,593,491UniSTSRnor5.0
RGSC_v3.4227,127,933 - 27,128,112UniSTSRGSC3.4
Celera224,044,243 - 24,044,422UniSTS
RH 3.4 Map220.1UniSTS
Cytogenetic Map2q12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2227,998,720 - 27,999,556 (+)MAPPERmRatBN7.2
Rnor_6.0227,481,422 - 27,482,257NCBIRnor6.0
Rnor_5.0246,594,079 - 46,594,914UniSTSRnor5.0
RGSC_v3.4227,128,700 - 27,129,535UniSTSRGSC3.4
Celera224,045,010 - 24,045,845UniSTS
Cytogenetic Map2q12UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 26 54 39 18 39 74 29 40 11
Low 17 3 2 1 2 8 11 6 1 8
Below cutoff


RefSeq Acc Id: ENSRNOT00000022055   ⟹   ENSRNOP00000022055
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl227,997,527 - 28,019,012 (-)Ensembl
Rnor_6.0 Ensembl227,480,226 - 27,500,654 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000096437   ⟹   ENSRNOP00000097467
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl227,997,525 - 28,019,703 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000101787   ⟹   ENSRNOP00000096084
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl227,997,525 - 28,019,056 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000112347   ⟹   ENSRNOP00000087297
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl227,997,525 - 28,016,019 (-)Ensembl
RefSeq Acc Id: NM_013134   ⟹   NP_037266
Rat AssemblyChrPosition (strand)Source
GRCr8229,732,165 - 29,753,623 (-)NCBI
mRatBN7.2227,997,525 - 28,018,983 (-)NCBI
Rnor_6.0227,480,226 - 27,500,654 (-)NCBI
Rnor_5.0246,592,881 - 46,614,276 (-)NCBI
RGSC_v3.4227,127,504 - 27,149,580 (-)RGD
Celera224,043,814 - 24,065,183 (-)RGD
RefSeq Acc Id: XM_006231826   ⟹   XP_006231888
Rat AssemblyChrPosition (strand)Source
GRCr8229,732,163 - 29,753,607 (-)NCBI
mRatBN7.2227,997,523 - 28,018,943 (-)NCBI
Rnor_6.0227,480,224 - 27,500,616 (-)NCBI
Rnor_5.0246,592,881 - 46,614,276 (-)NCBI
RefSeq Acc Id: XM_063281376   ⟹   XP_063137446
Rat AssemblyChrPosition (strand)Source
GRCr8229,732,163 - 29,754,276 (-)NCBI
RefSeq Acc Id: NP_037266   ⟸   NM_013134
- UniProtKB: Q64601 (UniProtKB/Swiss-Prot),   Q6P2A6 (UniProtKB/Swiss-Prot),   P51639 (UniProtKB/Swiss-Prot),   A6I512 (UniProtKB/TrEMBL),   A0A8L2QCN8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231888   ⟸   XM_006231826
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AUL2 (UniProtKB/TrEMBL),   A0A8L2QCN8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000022055   ⟸   ENSRNOT00000022055
RefSeq Acc Id: ENSRNOP00000096084   ⟸   ENSRNOT00000101787
RefSeq Acc Id: ENSRNOP00000087297   ⟸   ENSRNOT00000112347
RefSeq Acc Id: ENSRNOP00000097467   ⟸   ENSRNOT00000096437
RefSeq Acc Id: XP_063137446   ⟸   XM_063281376
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AV02 (UniProtKB/TrEMBL)
Protein Domains

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P51639-F1-model_v2 AlphaFold P51639 1-887 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13691084
Promoter ID:EPDNEW_R1609
Type:initiation region
Description:3-hydroxy-3-methylglutaryl-CoA reductase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.0227,500,681 - 27,500,741EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2803 AgrOrtholog
BioCyc Gene G2FUF-54777 BioCyc
BioCyc Pathway PWY-922 [mevalonate pathway I (eukaryotes and bacteria)] BioCyc
BioCyc Pathway Image PWY-922 BioCyc
Ensembl Genes ENSRNOG00000016122 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022055.5 UniProtKB/TrEMBL
  ENSRNOT00000096437.1 UniProtKB/TrEMBL
  ENSRNOT00000101787.1 UniProtKB/TrEMBL
  ENSRNOT00000112347.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.3270.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro HMG_CoA_Rdtase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HMG_CoA_Rdtase_cat_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HMG_CoA_Rdtase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HMG_CoA_Rdtase_eu_arc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HMG_CoA_Rdtase_metazoan UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HMG_CoA_Rdtase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HMG_CoA_Rdtase_NAD(P)-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HMG_CoA_Rdtase_sub-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25675 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10572 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HMG-CoA_red UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sterol-sensing UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hmgcr PhenoGen
  HMG_COA_REDUCTASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HMG_COA_REDUCTASE_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HMG_COA_REDUCTASE_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016122 RatGTEx
Superfamily-SCOP Multidrug efflux transporter AcrB transmembrane domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55035 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56542 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC238888
UniProt A0A8I6A6Z9_RAT UniProtKB/TrEMBL
UniProt Secondary Q64601 UniProtKB/Swiss-Prot
  Q6P2A6 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Hmgcr  3-hydroxy-3-methylglutaryl-CoA reductase  Hmgcr  3-hydroxy-3-methylglutaryl-Coenzyme A reductase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Hmgcr  3-hydroxy-3-methylglutaryl-Coenzyme A reductase      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function rate limiting enzyme in the cholesterologenesis pathway 1300058