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Gene: Hmgb1 (high mobility group box 1) Rattus norvegicus
Symbol: Hmgb1
Name: high mobility group box 1
RGD ID: 2802
Description: Exhibits several functions, including DNA binding activity; heparin binding activity; and signaling receptor binding activity. Involved in several processes, including positive regulation of cell differentiation; positive regulation of cytokine production; and response to bacterium. Localizes to several cellular components, including cytosol; extracellular space; and membrane raft. Used to study congestive heart failure; malignant glioma; myocardial infarction; pulmonary hypertension; and sciatic neuropathy. Biomarker of several diseases, including atherosclerosis; bilirubin metabolic disorder; colon adenocarcinoma; hydrocephalus; and middle cerebral artery infarction. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human HMGB1 (high mobility group box 1); PARTICIPATES IN pro-inflammatory cytokine mediated pathway; cisplatin drug pathway; mismatch repair pathway; INTERACTS WITH (+)-pilocarpine; 1,2-dimethylhydrazine; 17alpha-ethynylestradiol.
Type: protein-coding
Also known as: Ac2-008; Ac2-008-like; amphoterin; heparin-binding protein p30; high mobility group 1; high mobility group protein 1; high mobility group protein B1; HMG-1; Hmg1; LOC100361707; MGC93598; MGC93599
Homo sapiens (human) : HMGB1 (high mobility group box 1)  HGNC  Alliance
Mus musculus (house mouse) : Hmgb1 (high mobility group box 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hmgb1 (high mobility group box 1)
Pan paniscus (bonobo/pygmy chimpanzee) : HMGB1 (high mobility group box 1)
Canis lupus familiaris (dog) : HMGB1 (high mobility group box 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hmgb1 (high mobility group box 1)
Sus scrofa (pig) : HMGB1 (high mobility group box 1)
Heterocephalus glaber (naked mole-rat) : Hmgb1 (high mobility group box 1)
more info ...
Related Pseudogenes: Hmgb1-ps1   Hmgb1-ps2   Hmgb1-ps3   Hmgb1-ps4   LOC690117  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0127,082,529 - 7,090,246 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1637,500,017 - 37,502,237 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0129,177,615 - 9,178,878 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.11637,462,230 - 37,464,451 (+)NCBI
Celera127,732,744 - 7,737,689 (+)NCBICelera
Cytogenetic Map12p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Hmgb1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2802
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-11-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.