Hexa (hexosaminidase subunit alpha)

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Gene: Hexa (hexosaminidase subunit alpha) Rattus norvegicus

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Symbol:

Hexa

Name:

hexosaminidase subunit alpha

RGD ID:

2792

Description:

Predicted to enable acetylglucosaminyltransferase activity; beta-N-acetylhexosaminidase activity; and protein heterodimerization activity. Predicted to be involved in several processes, including N-glycan processing; ganglioside catabolic process; and glycosaminoglycan catabolic process. Predicted to act upstream of or within several processes, including adult walking behavior; nervous system development; and sensory perception of sound. Predicted to be located in azurophil granule and cytosol. Predicted to be part of beta-N-acetylhexosaminidase complex. Predicted to be active in lysosome and membrane. Human ortholog(s) of this gene implicated in Tay-Sachs disease. Orthologous to human HEXA (hexosaminidase subunit alpha); PARTICIPATES IN amino sugar metabolic pathway; french type sialuria pathway; sialic acid storage disease pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

beta-hexosaminidase subunit alpha; beta-N-acetylhexosaminidase subunit alpha; hexosaminidase A; hexosaminidase subunit A; Hexose aminidase A (alpha polypeptide); MGC95289; N-acetyl-beta-glucosaminidase subunit alpha

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	HEXA (hexosaminidase subunit alpha)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Hexa (hexosaminidase A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Hexa (hexosaminidase subunit alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	HEXA (hexosaminidase subunit alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	HEXA (hexosaminidase subunit alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Hexa (hexosaminidase subunit alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	HEXA (hexosaminidase subunit alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	HEXA (hexosaminidase subunit alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Hexa (hexosaminidase subunit alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Hexa (hexosaminidase A)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	HEXA (hexosaminidase subunit alpha)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	hexa (hexosaminidase A (alpha polypeptide))	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	hex-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Hexo1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Hexo2	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	fdl	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	68,832,524 - 68,857,462 (+)	NCBI		GRCr8
mRatBN7.2	8	59,936,526 - 59,961,654 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	59,936,660 - 59,962,013 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	65,458,741 - 65,483,646 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	63,731,762 - 63,756,562 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	61,601,107 - 61,626,013 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	64,325,435 - 64,350,775 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	64,325,435 - 64,350,773 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	64,087,247 - 64,112,587 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	63,363,219 - 63,388,146 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	63,382,272 - 63,407,200 (+)	NCBI
Celera	8	59,378,288 - 59,403,211 (+)	NCBI		Celera
Cytogenetic Map	8	q24	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Bloom syndrome (ISO)

Brugada syndrome 8 (ISO)

colorectal cancer (ISO)

Developmental Disabilities (ISO)

genetic disease (ISO)

GM2 gangliosidosis (ISO)

GM2 Gangliosidosis, AB variant (ISO)

Gm2-Gangliosidosis, Adult Chronic Type (ISO)

Gm2-Gangliosidosis, Variant B1 (ISO)

intellectual disability (ISO)

leukodystrophy (ISO)

Neurodevelopmental Disorders (ISO)

Tay-Sachs disease (ISO,ISS)

Tay-Sachs Disease, Juvenile (ISO)

Tay-Sachs Disease, Variant B1 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(1->4)-beta-D-glucan (ISO)

1,1-dichloroethene (ISO)

1,2-dimethylhydrazine (ISO)

1-chloro-2,4-dinitrobenzene (ISO)

17alpha-ethynylestradiol (EXP,ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (ISO)

2,4-dinitrotoluene (EXP)

3-chloropropane-1,2-diol (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-diaminodiphenylmethane (ISO)

6-propyl-2-thiouracil (EXP)

all-trans-retinoic acid (ISO)

amiodarone (ISO)

apigenin (ISO)

Aroclor 1254 (ISO)

azoxystrobin (ISO)

benzo[a]pyrene (ISO)

beta-lapachone (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

clofibrate (ISO)

compound 48/80 (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) chloride (ISO)

cyclosporin A (ISO)

deguelin (ISO)

dexamethasone (ISO)

diuron (ISO)

divanadium pentaoxide (ISO)

dorsomorphin (ISO)

endosulfan (EXP)

flunarizine (EXP)

flutamide (EXP,ISO)

folic acid (ISO)

folpet (ISO)

gentamycin (EXP)

glafenine (EXP)

indometacin (ISO)

inulin (ISO)

isoprenaline (ISO)

ivermectin (ISO)

mercury dibromide (ISO)

methimazole (EXP)

methyl methanesulfonate (ISO)

Mibefradil (EXP)

N(4)-hydroxycytidine (ISO)

N,O-dimethyltyramine (ISO)

nefazodone (EXP)

paracetamol (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

phosphorus atom (ISO)

phosphorus(.) (ISO)

pyrimidifen (ISO)

resveratrol (ISO)

rotenone (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

sodium fluoride (ISO)

Soman (EXP)

sulfadimethoxine (EXP)

tacrolimus hydrate (ISO)

tamoxifen (ISO)

tetrachloromethane (EXP,ISO)

titanium dioxide (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Yessotoxin (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adult walking behavior (ISO)

carbohydrate derivative metabolic process (IEA)

carbohydrate metabolic process (IEA)

cell morphogenesis involved in neuron differentiation (ISO)

dermatan sulfate catabolic process (ISO)

ganglioside catabolic process (IBA,ISO,ISS)

glycosaminoglycan biosynthetic process (ISO)

glycosaminoglycan metabolic process (IBA,ISO)

hyaluronan catabolic process (ISO)

lipid metabolic process (IEA)

lipid storage (ISO)

locomotory behavior (ISO)

lysosome organization (ISO)

maintenance of location in cell (ISO)

myelination (ISO)

N-glycan processing (IBA)

neuromuscular process controlling balance (ISO)

neuromuscular process controlling posture (ISO)

sensory perception of sound (ISO)

sexual reproduction (ISO)

skeletal system development (ISO)

Cellular Component

azurophil granule (ISO)

beta-N-acetylhexosaminidase complex (ISO)

cytosol (IEA,ISO)

intracellular membrane-bounded organelle (ISO)

lysosome (IBA,IEA,ISO)

membrane (IBA,ISO)

Molecular Function

acetylglucosaminyltransferase activity (ISO)

beta-N-acetylglucosaminidase activity (IEA)

beta-N-acetylhexosaminidase activity (IBA,IEA,ISO,ISS)

protein binding (ISO)

protein heterodimerization activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

amino sugar metabolic pathway (IEA,ISO)

french type sialuria pathway (ISO)

ganglioside metabolic pathway (IEA)

globoside metabolic pathway (IEA)

glycosaminoglycan degradation pathway (IEA)

nucleotide sugar metabolic pathway (IEA)

sialic acid storage disease pathway (ISO)

Tay-Sachs disease pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Pharmacological modification of the serotonergic transmitter system and beta-N-acetylhexosaminidase activity in rats.	Casal JA, etal., Life Sci 2000 Sep 29;67(19):2369-74.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Postnatal development and regulation of beta-hexosaminidase in epithelial cells of the rat epididymis.	Hermo L, etal., J Androl 2004 Jan-Feb;25(1):69-81.
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
6.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
7.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
8.	GOA pipeline	RGD automated data pipeline
9.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
11.	Murine Sialidase Neu3 facilitates GM2 degradation and bypass in mouse model of Tay-Sachs disease.	Seyrantepe V, etal., Exp Neurol. 2018 Jan;299(Pt A):26-41. doi: 10.1016/j.expneurol.2017.09.012. Epub 2017 Sep 30.
12.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
13.	Structural organization, sequence, and expression of the mouse HEXA gene encoding the alpha subunit of hexosaminidase A.	Wakamatsu N, etal., Genomics 1994 Nov 1;24(1):110-9.

Additional References at PubMed

PMID:1914521	PMID:6230359	PMID:7937929	PMID:8747922	PMID:8789434	PMID:8896570	PMID:9103204	PMID:9184660	PMID:9223328	PMID:9302266	PMID:9417048	PMID:9645704
PMID:10021458	PMID:10196372	PMID:10591619	PMID:11854359	PMID:14972652	PMID:15489334	PMID:19946888	PMID:23376485	PMID:23390484	PMID:23533145	PMID:25645918

Genomics

Comparative Map Data

Hexa
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	68,832,524 - 68,857,462 (+)	NCBI		GRCr8
mRatBN7.2	8	59,936,526 - 59,961,654 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	59,936,660 - 59,962,013 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	65,458,741 - 65,483,646 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	63,731,762 - 63,756,562 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	61,601,107 - 61,626,013 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	64,325,435 - 64,350,775 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	64,325,435 - 64,350,773 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	64,087,247 - 64,112,587 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	63,363,219 - 63,388,146 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	63,382,272 - 63,407,200 (+)	NCBI
Celera	8	59,378,288 - 59,403,211 (+)	NCBI		Celera
Cytogenetic Map	8	q24	NCBI

HEXA
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	72,340,924 - 72,376,014 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	72,340,924 - 72,376,420 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	15	72,633,265 - 72,668,355 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	70,422,832 - 70,455,457 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	15	70,422,832 - 70,455,393	NCBI
Celera	15	49,521,918 - 49,554,688 (-)	NCBI		Celera
Cytogenetic Map	15	q23	NCBI
HuRef	15	49,466,005 - 49,498,776 (-)	NCBI		HuRef
CHM1_1	15	72,753,786 - 72,786,527 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	15	70,157,399 - 70,192,818 (-)	NCBI		T2T-CHM13v2.0

Hexa
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	59,446,966 - 59,472,392 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	59,446,823 - 59,472,392 (+)	Ensembl		GRCm39 Ensembl
GRCm38	9	59,539,540 - 59,565,109 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	59,539,540 - 59,565,109 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	59,387,474 - 59,412,912 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	59,337,673 - 59,363,111 (+)	NCBI		MGSCv36	mm8
Celera	9	56,766,853 - 56,792,230 (+)	NCBI		Celera
Cytogenetic Map	9	B	NCBI
cM Map	9	32.02	NCBI

Hexa
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955450	4,790,268 - 4,806,734 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955450	4,790,342 - 4,806,862 (+)	NCBI	ChiLan1.0	ChiLan1.0

HEXA
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	61,548,795 - 61,643,064 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	65,707,784 - 65,807,320 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	51,235,123 - 51,326,832 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	70,034,232 - 70,090,688 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	69,998,866 - 70,033,749 (-)	Ensembl	panpan1.1		panPan2
PanPan1.1 Ensembl	15	70,057,943 - 70,090,688 (-)	Ensembl	panpan1.1		panPan2

HEXA
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	30	35,836,788 - 35,862,525 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	30	35,772,553 - 35,799,681 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	30	36,041,265 - 36,068,396 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	30	36,039,878 - 36,068,382 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	30	35,993,838 - 36,020,876 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	30	36,021,266 - 36,048,385 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	30	36,277,065 - 36,304,204 (-)	NCBI		UU_Cfam_GSD_1.0

Hexa
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	113,863,160 - 113,890,243 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936471	31,709,491 - 31,738,245 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936471	31,712,485 - 31,738,273 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HEXA
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	60,878,284 - 60,913,339 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	60,878,531 - 60,911,537 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	65,420,894 - 65,453,741 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

HEXA
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	11,081,985 - 11,130,366 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	26	11,082,468 - 11,116,075 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	130,463,174 - 130,496,786 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Hexa
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624781	1,686,384 - 1,714,684 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624781	1,686,818 - 1,706,044 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Hexa
100 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	159
Count of miRNA genes:	124
Interacting mature miRNAs:	136
Transcripts:	ENSRNOT00000013747
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1298065	Scl16	Serum cholesterol level QTL 16	3.8		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	8	30856404	75856404	Rat
1554321	Bmd3	Bone mineral density QTL 3	7.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	40952565	123900184	Rat
1578769	Uae31	Urinary albumin excretion QTL 31	3.3	0.001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	30848154	101699754	Rat
1298079	Activ2	Activity QTL 2	9.5	0.000001	voluntary movement trait (VT:0003491)	rearing measurement (CMO:0001515)	8	41866876	86866876	Rat
11556286	Cm81	Cardiac mass QTL 81		0.01	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	30848154	61290444	Rat
70161	Bp62	Blood pressure QTL 62	2.9	0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	42692684	90165460	Rat
1578765	Klgr1	Kidney lesion grade QTL 1	3.3	0.0001	kidney morphology trait (VT:0002135)	organ lesion measurement (CMO:0000677)	8	30848154	101699754	Rat
1582222	Epfw2	Epididymal fat weight QTL 2	3.2	0.0005	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	8	31737729	76737729	Rat
61464	Niddm11	Non-insulin dependent diabetes mellitus QTL 11	3.1	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	8	35582032	80582032	Rat
4889938	Bss89	Bone structure and strength QTL 89	3.8		tibia size trait (VT:0100001)	tibia cortical bone volume (CMO:0001725)	8	50095249	82460899	Rat
1578755	Pur5	Proteinuria QTL 5	3.3	0.0001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	8	30848154	101699754	Rat
1300146	Rf17	Renal function QTL 17	2.9		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	8	28242912	73242912	Rat
2313088	Bss75	Bone structure and strength QTL 75	3.1	0.0001	body length (VT:0001256)	body length, nose to rump (CMO:0000079)	8	30848154	82460899	Rat
8662823	Vetf5	Vascular elastic tissue fragility QTL 5	1.9		artery integrity trait (VT:0010639)	patent ductus arteriosus score (CMO:0002566)	8	28242912	99525068	Rat
1358896	Bp262	Blood pressure QTL 262	2.89		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	27205715	99103503	Rat
731182	Uae24	Urinary albumin excretion QTL 24	6.4		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	19331152	93965294	Rat
724514	Uae15	Urinary albumin excretion QTL 15	2.9		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	29502665	70386295	Rat
61353	Bp35	Blood pressure QTL 35		0.001	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	8	30848154	61290444	Rat
737824	Hcar10	Hepatocarcinoma resistance QTL 10	2.9		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	8	40713066	82925667	Rat
631842	Inf1	Infertility severity QTL 1	4.1	0.001	seminal gland mass (VT:0010524)	seminal vesicle wet weight (CMO:0001603)	8	22662330	67662330	Rat
1331769	Rf39	Renal function QTL 39	3.871		urine output (VT:0003620)	timed urine volume (CMO:0000260)	8	41866876	75097878	Rat
1359033	Bp273	Blood pressure QTL 273			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	30848154	61290444	Rat
1358906	Bp253	Blood pressure QTL 253	4	0.0004	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	40713066	93965294	Rat
61358	Bp39	Blood pressure QTL 39	2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	35551938	80551938	Rat
1358907	Cm40	Cardiac mass QTL 40	1.89		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	27205715	99103503	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	46531639	119088626	Rat
2316950	Scl66	Serum cholesterol level QTL 66	4.1		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	8	30848259	105647037	Rat
1582254	Kidm31	Kidney mass QTL 31	3		kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	8	54237644	85365202	Rat
10402857	Bp380	Blood pressure QTL 380		0.95	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	53968765	98968765	Rat
1358892	Kidm26	Kidney mass QTL 26	3.69		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	8	27205715	99103503	Rat
631216	Stl9	Serum triglyceride level QTL 9	4.71	0.0001	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	8	41867010	70386132	Rat
1582243	Bw66	Body weight QTL 66	3.4	0.0048	body mass (VT:0001259)	body weight (CMO:0000012)	8	54237644	85365202	Rat
5684973	Bss100	Bone structure and strength QTL 100	4.7		tibia area (VT:1000281)	tibia area measurement (CMO:0001382)	8	50095249	82460899	Rat
61373	Mcs4	Mammary carcinoma susceptibility QTL 4	1.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	8	16290444	61290444	Rat
1300177	Cm2	Cardiac mass QTL 2	3.65		heart mass (VT:0007028)	heart weight (CMO:0000017)	8	54259986	100382532	Rat
2313057	Bss76	Bone structure and strength QTL 76	3	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	8	30848154	82460899	Rat
12879878	Bw183	Body weight QTL 183		0.001	body mass (VT:0001259)	body weight (CMO:0000012)	8	43296169	98968765	Rat
1549908	Neudeg1	Neurodegradation QTL 1	5.5	0	nervous system integrity trait (VT:0010566)	logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)	8	30188867	94457446	Rat
12879879	Cm99	Cardiac mass QTL 99		0.001	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	43296169	98968765	Rat
2313067	Bss77	Bone structure and strength QTL 77	3.1	0.0001	tibia size trait (VT:0100001)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	8	30848154	82460899	Rat
12879880	Cm100	Cardiac mass QTL 100		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	8	43296169	98968765	Rat
12879881	Cm101	Cardiac mass QTL 101		0.001	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	8	43296169	98968765	Rat
12879882	Am8	Aortic mass QTL 8		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	8	43296169	98968765	Rat
12879883	Kidm65	Kidney mass QTL 65		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	8	43296169	98968765	Rat
1358912	Bw51	Body weight QTL 51	2.95		body mass (VT:0001259)	body weight (CMO:0000012)	8	51351728	107062046	Rat
2313086	Bss60	Bone structure and strength QTL 60	4.1	0.0001	tibia length (VT:0004357)	tibia length (CMO:0000450)	8	50095249	82460899	Rat
2293697	Bmd39	Bone mineral density QTL 39			femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	8	54043744	98968765	Rat
1331837	Bw23	Body weight QTL 23	4.19	0.00007	body mass (VT:0001259)	body weight (CMO:0000012)	8	46531722	99083736	Rat
1331838	Niddm61	Non-insulin dependent diabetes mellitus QTL 61	3.53	0.0004	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	8	36469535	99083736	Rat
631650	Stl6	Serum triglyceride level QTL 6	4	0.0019	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	10378157	112202585	Rat
1581557	Eae16	Experimental allergic encephalomyelitis QTL 16	3.8		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	8	8462195	110921472	Rat
631271	Lecl1	Lens clarity QTL 1		0.001	lens clarity trait (VT:0001304)	age of onset/diagnosis of cataract (CMO:0001584)	8	18984168	84531599	Rat
2303564	Gluco43	Glucose level QTL 43	3		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	8	26130187	71130187	Rat
2303570	Gluco48	Glucose level QTL 48	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	8	49805831	94805831	Rat
2313046	Bss78	Bone structure and strength QTL 78	3.5	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	8	30848154	82460899	Rat
2303572	Insul13	Insulin level QTL 13	2		blood insulin amount (VT:0001560)	blood insulin level (CMO:0000349)	8	26130187	71130187	Rat
631664	Hcar3	Hepatocarcinoma resistance QTL 3	2.9	0.0005	liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	8	54237644	99103503	Rat
2301402	Bp316	Blood pressure QTL 316		0.005	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	53968765	98968765	Rat

Markers in Region

RH134318

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	59,955,830 - 59,957,479 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	64,344,952 - 64,346,600	NCBI	Rnor6.0
Rnor_5.0	8	64,106,764 - 64,108,412	UniSTS	Rnor5.0
RGSC_v3.4	8	63,382,334 - 63,383,982	UniSTS	RGSC3.4
Celera	8	59,397,399 - 59,399,047	UniSTS
Cytogenetic Map	8	q24	UniSTS

RH136740

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	59,961,726 - 59,961,912 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	64,350,848 - 64,351,033	NCBI	Rnor6.0
Rnor_5.0	8	64,112,660 - 64,112,845	UniSTS	Rnor5.0
RGSC_v3.4	8	63,388,230 - 63,388,415	UniSTS	RGSC3.4
Celera	8	59,403,295 - 59,403,480	UniSTS
Cytogenetic Map	8	q24	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001004443	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017595561	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063265129	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC082097	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473975	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000013747 ⟹ ENSRNOP00000013747

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	59,936,726 - 59,961,640 (+)	Ensembl
Rnor_6.0 Ensembl	8	64,325,435 - 64,350,773 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000105014 ⟹ ENSRNOP00000085099

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	59,936,660 - 59,961,657 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000108506 ⟹ ENSRNOP00000084550

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	59,936,707 - 59,962,013 (+)	Ensembl

RefSeq Acc Id:

NM_001004443 ⟹ NP_001004443

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	68,832,524 - 68,857,451 (+)	NCBI
mRatBN7.2	8	59,936,714 - 59,961,643 (+)	NCBI
Rnor_6.0	8	64,325,435 - 64,350,764 (+)	NCBI
Rnor_5.0	8	64,087,247 - 64,112,587 (+)	NCBI
RGSC_v3.4	8	63,363,219 - 63,388,146 (+)	RGD
Celera	8	59,378,288 - 59,403,211 (+)	RGD

Sequence:

show sequence

GCCTGCTGGAAGGGGAGCTGGCCGGTGGGCCATGGCCGGCTGCAGGCTCTGGGTTTCGCTGCTG
CTGGCGGCGGCGTTGGCTTGCTTGGCCACGGCGCTGTGGCCCTGGCCCCAGTACATCCAAACCT
CCCACCGGCGCTACACCCTGTACCCCAACAACTTCCAGTTCCGGTACCATGCCGGTTCGGCCGC
GCAGGCGGGCTGCGTTGTCCTCGACGAGGCCTTTCGACGCTACCGTAGCCTGCTCTTCGGTTCC
GGCTCTTGGCCCCGACCCAGCTTCTCAAAAAAACAGCAGCCGTTGGGGAAGAACATTCTGATGG
TCTCTGTCGTCACAGCCGAATGTAATGAGTTTCCTAATTTGGAGTCCGTAGAAAATTACACCCT
AACCATTAATGATGACCAGTGTTTACTCTCCTCTGAGACTGTCTGGGGCGCTCTGCGAGGTCTG
GAGACTTTCAGTCAGCTTGTTTGGAAGTCAGCTGAGGGCACGTTCTTTATCAACAAGACAAAGA
TTACAGACTTTCCTCGATTCCCTCACCGGGGCATACTGCTGGATACATCTCGCCATTACCTGCC
GTTATCTAGCATCCTGAACACACTGGATGTCATGGCGTACAATAAATTCAACGTGTTCCACTGG
CACTTGGTGGACGACTCTTCCTTCCCATACGAGAGCTTCACCTTCCCAGAGCTCACCAGAAAGG
GGTCCTTCAACCCTGTTACCCACATCTACACAGCACAGGATGTGAAGGAGGTCATTGAATATGC
AAGGCTTCGGGGTATCCGAGTGCTGGCCGAATTTGACACTCCTGGCCACACTTTGTCCTGGGGG
GCAGGTGTCCCTGGATTATTAACACCTTGCTACTCTGGGTCCCGTCTCTCTGGCACCTATGGAC
CTGTGAACCCCAGCCTCAACAGCACCTACGACTTCATGAGCACATTCTTCCTGGAGATCAGCTC
TGTCTTCCCTGACTTTTATCTCCACCTGGGAGGAGATGAAGTTGACTTCACCTGCTGGAAGTCC
AACCCCAACATCCAGGCCTTCATGAAGAAAAAGGGCTTTACTGACTACAAGCAGCTGGAGTCAT
TCTACATCCAGACGCTGCTGGACATCGTCTCTGATTATGACAAGGGCTATGTGGTGTGGCAGGA
AGTATTTGATAATAAAGTGAAGGTTCGGCCAGACACAATCATACAGGTGTGGCGGGAAGAGATG
CCGGTCCAGTACATGAAGGAGATAGAGGCCATCACCCAGGCTGGCTTCCGGGCCCTGCTGTCTG
CTCCCTGGTACCTGAACCGGGTGAAGTATGGCCCTGACTGGAAGGAAATGTACAAAGTGGAGCC
CCTGGCATTTCGTGGTACACCTGCACAAAAGGCTCTGGTCATTGGAGGGGAAGCCTGTATGTGG
GGAGAGTATGTGGACAGCACAAACCTTGTCCCCAGGCTCTGGCCCAGAGCAGGTGCCATTGCCG
AAAGACTGTGGAGCAGTAACCTGACGACTAATATGGACTTTGCCTTTAAACGTCTGTCCCATTT
CCGCTGTGAGCTGCTGAGGAGAGGAATCCAGGCCCAGCCCATCAGCGTGGGCTACTGTGAGCAG
GAGTTTGAGCATACTTGAGCCAGCAGTACTGAGCACCCAGGAGGCCTTAAGAGAGCAGTTCCCG
GGTTAGGCTTCCACTGCCTCCCTGCAGGGGGAGAAAGCCCCTGGCCCATGTGCTCCTGTGACTA
GAGAGGAGGAGGCTGGTGCTGGCACTGGTGTTCAATAAAGATCTATGTGGC

hide sequence

RefSeq Acc Id:

XM_017595561 ⟹ XP_017451050

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	68,832,668 - 68,857,462 (+)	NCBI
mRatBN7.2	8	59,936,859 - 59,961,654 (+)	NCBI
Rnor_6.0	8	64,335,255 - 64,350,775 (+)	NCBI

Sequence:

show sequence

CAAACACTTATTGACTGACTACCGTGTATCAGGCACTGGGAACACAAAGACACAGATTGGTCCC
TGCTGTTGAGGAACTTACAGCCTAGAAAAACAGCAGCCGTTGGGGAAGAACATTCTGATGGTCT
CTGTCGTCACAGCCGAATGTAATGAGTTTCCTAATTTGGAGTCCGTAGAAAATTACACCCTAAC
CATTAATGATGACCAGTGTTTACTCTCCTCTGAGACTGTCTGGGGCGCTCTGCGAGGTCTGGAG
ACTTTCAGTCAGCTTGTTTGGAAGTCAGCTGAGGGCACGTTCTTTATCAACAAGACAAAGATTA
CAGACTTTCCTCGATTCCCTCACCGGGGCATACTGCTGGATACATCTCGCCATTACCTGCCGTT
ATCTAGCATCCTGAACACACTGGATGTCATGGCGTACAATAAATTCAACGTGTTCCACTGGCAC
TTGGTGGACGACTCTTCCTTCCCATACGAGAGCTTCACCTTCCCAGAGCTCACCAGAAAGGGGT
CCTTCAACCCTGTTACCCACATCTACACAGCACAGGATGTGAAGGAGGTCATTGAATATGCAAG
GCTTCGGGGTATCCGAGTGCTGGCCGAATTTGACACTCCTGGCCACACTTTGTCCTGGGGGGCA
GGTGTCCCTGGATTATTAACACCTTGCTACTCTGGGTCCCGTCTCTCTGGCACCTATGGACCTG
TGAACCCCAGCCTCAACAGCACCTACGACTTCATGAGCACATTCTTCCTGGAGATCAGCTCTGT
CTTCCCTGACTTTTATCTCCACCTGGGAGGAGATGAAGTTGACTTCACCTGCTGGAAGTCCAAC
CCCAACATCCAGGCCTTCATGAAGAAAAAGGGCTTTACTGACTACAAGCAGCTGGAGTCATTCT
ACATCCAGACGCTGCTGGACATCGTCTCTGATTATGACAAGGGCTATGTGGTGTGGCAGGAAGT
ATTTGATAATAAAGTGAAGGTTCGGCCAGACACAATCATACAGGTGTGGCGGGAAGAGATGCCG
GTCCAGTACATGAAGGAGATAGAGGCCATCACCCAGGCTGGCTTCCGGGCCCTGCTGTCTGCTC
CCTGGTACCTGAACCGGGTGAAGTATGGCCCTGACTGGAAGGAAATGTACAAAGTGGAGCCCCT
GGCATTTCGTGGTACACCTGCACAAAAGGCTCTGGTCATTGGAGGGGAAGCCTGTATGTGGGGA
GAGTATGTGGACAGCACAAACCTTGTCCCCAGGCTCTGGCCCAGAGCAGGTGCCATTGCCGAAA
GACTGTGGAGCAGTAACCTGACGACTAATATGGACTTTGCCTTTAAACGTCTGTCCCATTTCCG
CTGTGAGCTGCTGAGGAGAGGAATCCAGGCCCAGCCCATCAGCGTGGGCTACTGTGAGCAGGAG
TTTGAGCATACTTGAGCCAGCAGTACTGAGCACCCAGGAGGCCTTAAGAGAGCAGTTCCCGGGT
TAGGCTTCCACTGCCTCCCTGCAGGGGGAGAAAGCCCCTGGCCCATGTGCTCCTGTGACTAGAG
AGGAGGAGGCTGGTGCTGGCACTGGTGTTCAATAAAGATCTATGTGGCATTTTCTCTAA

hide sequence

RefSeq Acc Id:

XM_063265129 ⟹ XP_063121199

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	68,832,555 - 68,855,482 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001004443	(Get FASTA)	NCBI Sequence Viewer
	XP_017451050	(Get FASTA)	NCBI Sequence Viewer
	XP_063121199	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH82097	(Get FASTA)	NCBI Sequence Viewer
	EDL95699	(Get FASTA)	NCBI Sequence Viewer
	EDL95700	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000013747.5
	ENSRNOP00000084550.1
	ENSRNOP00000085099.1
	ENSRNOP00055038495
	ENSRNOP00060022084
	ENSRNOP00065008066
GenBank Protein	Q641X3	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001004443 ⟸ NM_001004443
- Peptide Label:	precursor
- UniProtKB:	Q641X3 (UniProtKB/Swiss-Prot), A0A8L2Q7B4 (UniProtKB/TrEMBL), A6J526 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAGCRLWVSLLLAAALACLATALWPWPQYIQTSHRRYTLYPNNFQFRYHAGSAAQAGCVVLDEA FRRYRSLLFGSGSWPRPSFSKKQQPLGKNILMVSVVTAECNEFPNLESVENYTLTINDDQCLLS SETVWGALRGLETFSQLVWKSAEGTFFINKTKITDFPRFPHRGILLDTSRHYLPLSSILNTLDV MAYNKFNVFHWHLVDDSSFPYESFTFPELTRKGSFNPVTHIYTAQDVKEVIEYARLRGIRVLAE FDTPGHTLSWGAGVPGLLTPCYSGSRLSGTYGPVNPSLNSTYDFMSTFFLEISSVFPDFYLHLG GDEVDFTCWKSNPNIQAFMKKKGFTDYKQLESFYIQTLLDIVSDYDKGYVVWQEVFDNKVKVRP DTIIQVWREEMPVQYMKEIEAITQAGFRALLSAPWYLNRVKYGPDWKEMYKVEPLAFRGTPAQK ALVIGGEACMWGEYVDSTNLVPRLWPRAGAIAERLWSSNLTTNMDFAFKRLSHFRCELLRRGIQ AQPISVGYCEQEFEHT hide sequence

RefSeq Acc Id:	XP_017451050 ⟸ XM_017595561
- Peptide Label:	isoform X1
- UniProtKB:	A0A8L2Q7B4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MVSVVTAECNEFPNLESVENYTLTINDDQCLLSSETVWGALRGLETFSQLVWKSAEGTFFINKT KITDFPRFPHRGILLDTSRHYLPLSSILNTLDVMAYNKFNVFHWHLVDDSSFPYESFTFPELTR KGSFNPVTHIYTAQDVKEVIEYARLRGIRVLAEFDTPGHTLSWGAGVPGLLTPCYSGSRLSGTY GPVNPSLNSTYDFMSTFFLEISSVFPDFYLHLGGDEVDFTCWKSNPNIQAFMKKKGFTDYKQLE SFYIQTLLDIVSDYDKGYVVWQEVFDNKVKVRPDTIIQVWREEMPVQYMKEIEAITQAGFRALL SAPWYLNRVKYGPDWKEMYKVEPLAFRGTPAQKALVIGGEACMWGEYVDSTNLVPRLWPRAGAI AERLWSSNLTTNMDFAFKRLSHFRCELLRRGIQAQPISVGYCEQEFEHT hide sequence

Ensembl Acc Id:

ENSRNOP00000013747 ⟸ ENSRNOT00000013747

Ensembl Acc Id:

ENSRNOP00000084550 ⟸ ENSRNOT00000108506

Ensembl Acc Id:

ENSRNOP00000085099 ⟸ ENSRNOT00000105014

RefSeq Acc Id:	XP_063121199 ⟸ XM_063265129
- Peptide Label:	isoform X2

Protein Domains

Beta-hexosaminidase eukaryotic type N-terminal Glycoside hydrolase family 20 catalytic

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q641X3-F1-model_v2	AlphaFold	Q641X3	1-528	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13696040

Promoter ID:

EPDNEW_R6564

Type:

initiation region

Name:

Hexa_1

Description:

hexosaminidase subunit alpha

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	8	64,325,425 - 64,325,485	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2792	AgrOrtholog
BioCyc Gene	G2FUF-30238	BioCyc
BioCyc Pathway	PWY-6902 [chitin degradation II (Vibrio)]	BioCyc
BioCyc Pathway Image	PWY-6902	BioCyc
Ensembl Genes	ENSRNOG00000010252	Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSRNOG00055027102	UniProtKB/Swiss-Prot
	ENSRNOG00060016046	UniProtKB/Swiss-Prot
	ENSRNOG00065007034	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000013747.5	UniProtKB/TrEMBL
	ENSRNOT00000105014.1	UniProtKB/TrEMBL
	ENSRNOT00000108506.1	UniProtKB/Swiss-Prot
	ENSRNOT00055046863	UniProtKB/Swiss-Prot
	ENSRNOT00060027496	UniProtKB/Swiss-Prot
	ENSRNOT00065010982	UniProtKB/Swiss-Prot
Gene3D-CATH	3.30.379.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Glycosidases	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7134440	IMAGE-MGC_LOAD
InterPro	Beta_hexosaminidase_sua/sub	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Glyco_hydro_20_cat	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Glycoside_hydrolase_SF	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Hex-like_dom2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HEX_eukaryotic_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:300757	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:95289	IMAGE-MGC_LOAD
NCBI Gene	Hexa	ENTREZGENE
PANTHER	BETA-HEXOSAMINIDASE SUBUNIT ALPHA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR22600	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Glyco_hydro_20	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Glycohydro_20b2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Hexa	PhenoGen
PIRSF	B-hxosamndse_ab_euk	UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
PRINTS	GLHYDRLASE20	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	PROKAR_LIPOPROTEIN	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000010252	RatGTEx
	ENSRNOG00055027102	RatGTEx
	ENSRNOG00060016046	RatGTEx
	ENSRNOG00065007034	RatGTEx
Superfamily-SCOP	SSF51445	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF55545	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I5ZZD2_RAT	UniProtKB/TrEMBL
	A0A8L2Q7B4	ENTREZGENE, UniProtKB/TrEMBL
	A6J526	ENTREZGENE, UniProtKB/TrEMBL
	A6J527_RAT	UniProtKB/TrEMBL
	HEXA_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-25	Hexa	hexosaminidase subunit alpha	Hexa	hexosaminidase A	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-06-10	Hexa	Hexose aminidase A (alpha polypeptide)			Symbol and Name status set to approved	70586	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

BioCyc Pathways

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

BioCyc Pathways