Gsta1 (glutathione S-transferase alpha 1) - Rat Genome Database

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Gene: Gsta1 (glutathione S-transferase alpha 1) Rattus norvegicus
Analyze
Symbol: Gsta1
Name: glutathione S-transferase alpha 1
RGD ID: 2753
Description: Enables dinitrosyl-iron complex binding activity; glutathione binding activity; and glutathione transferase activity. Involved in response to nutrient levels and xenobiotic catabolic process. Located in cytosol. Human ortholog(s) of this gene implicated in asthma and ovarian cancer. Orthologous to several human genes including GSTA1 (glutathione S-transferase alpha 1); PARTICIPATES IN glutathione conjugation pathway; INTERACTS WITH 1,2-dimethylhydrazine; 1-chloro-2,4-dinitrobenzene; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: glutathione S-transferase A1; glutathione S-transferase A3; glutathione S-transferase A3 subunit; glutathione S-transferase A5; glutathione S-transferase alpha 3; glutathione S-transferase alpha-3; glutathione S-transferase Yc-1; glutathione S-transferase Yc1 subunit; glutathione S-transferase, alpha 1; glutathione transferase A3 subunit; Glutathione-S-transferase alpha type (Ya); Glutathione-S-transferase, alpha type (Ya); GST 2-2; GST A3-3; GST AA; GST Yc1; Gsta3; Gsta5; LOC108348061; MGC112704; Yc1
RGD Orthologs
Human
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8931,199,887 - 31,216,606 (-)NCBIGRCr8
mRatBN7.2923,703,476 - 23,720,121 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl923,703,477 - 23,720,121 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx932,196,752 - 32,213,351 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0937,317,434 - 37,334,033 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0935,632,677 - 35,649,276 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0927,366,404 - 27,381,004 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl927,368,272 - 27,452,902 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0926,283,550 - 26,300,195 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4920,051,501 - 20,068,146 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1920,048,823 - 20,065,988 (-)NCBI
Celera921,278,681 - 21,295,265 (-)NCBICelera
Cytogenetic Map9q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinin  (ISO)
1,2-Dibromo-3-chloropropane  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP)
1-chloro-2,4-dinitrobenzene  (EXP,ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
13-oxo-9,11-octadecadienoic acid  (ISO)
17-beta-Estradiol-3,17-beta-sulfate  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-Acetoxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine  (ISO)
2-allylphenol  (ISO)
2-hexenal  (EXP)
2-phenylpropanal  (ISO)
3,4,8-Trimethyl-1H,2H,3H-imidazo[4,5-F]quinoxalin-2-imine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-methylpyridine  (ISO)
4-hydroxynon-2-enal  (EXP,ISO)
4-nitrophenol  (EXP)
4-Propylphenol  (ISO)
5-Hydroxythalidomide  (ISO)
7,12-dimethyltetraphene  (EXP)
8-anilinonaphthalene-1-sulfonic acid  (ISO)
acetamide  (EXP)
acrolein  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
alpha-linolenic acid  (ISO)
alpha-methyl-L-dopa  (ISO)
alternariol  (ISO)
aluminium oxide  (EXP)
amitrole  (EXP)
androst-4-ene-3,17-dione  (ISO)
androst-5-ene-3,17-dione  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
Aroclor 1254  (ISO)
arotinoid acid  (ISO)
arsenous acid  (ISO)
atazanavir sulfate  (ISO)
atrazine  (EXP,ISO)
Azaspiracid  (ISO)
azathioprine  (ISO)
Bardoxolone methyl  (ISO)
benidipine  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[a]pyrene-7,8-diol  (EXP)
benzoic acid  (ISO)
beta-naphthoflavone  (ISO)
bilirubin IXalpha  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bromosulfophthalein  (EXP,ISO)
brucine  (EXP)
bucladesine  (ISO)
busulfan  (ISO)
butane-2,3-dione  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbamazepine  (ISO)
chenodeoxycholic acid  (ISO)
CHIR 99021  (ISO)
chlorambucil  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
cholic acid  (EXP)
ciprofibrate  (EXP)
cisplatin  (EXP,ISO)
clozapine  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP)
copper(II) sulfate  (ISO)
cortisol  (ISO)
cumene hydroperoxide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
DDT  (EXP)
deoxycholic acid  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dicrotophos  (ISO)
diethyl maleate  (ISO)
dimethyl sulfoxide  (EXP)
dinophysistoxin 1  (ISO)
dioxygen  (ISO)
diquat  (EXP)
dopamine  (ISO)
doxorubicin  (EXP,ISO)
ebselen  (EXP)
enzyme inhibitor  (EXP)
Erucin  (EXP)
etacrynic acid  (EXP,ISO)
ethyl methanesulfonate  (ISO)
eugenol  (ISO)
genistein  (EXP)
gentamycin  (EXP)
glutathione  (EXP,ISO)
Glutathione ethyl ester  (EXP)
glycochenodeoxycholic acid  (EXP,ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
GW 7647  (EXP,ISO)
herbicide  (EXP)
hexadecanoic acid  (ISO)
hydrogen peroxide  (EXP,ISO)
hypericin  (ISO)
Idoxifene  (EXP)
iodide salt  (EXP)
iomeprol  (EXP)
isomethyleugenol  (ISO)
isoprenaline  (EXP)
kaempferol  (ISO)
ketoconazole  (EXP,ISO)
KT 5720  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
lauroyl-CoA  (ISO)
lead diacetate  (EXP,ISO)
lead nitrate  (ISO)
linoleic acid  (ISO)
lithocholic acid  (EXP,ISO)
luteolin  (EXP)
LY294002  (ISO)
mefenamic acid  (ISO)
MeIQx  (ISO)
menadione  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
metformin  (EXP)
methotrexate  (ISO)
methyl methacrylate  (ISO)
microcystin RR  (ISO)
microcystin-LR  (EXP,ISO)
mifepristone  (ISO)
myristoyl-CoA  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (EXP)
N-acetyl-S-phenyl-L-cysteine  (ISO)
N-acetylsphingosine  (ISO)
N-hydroxy-PhIP  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nefazodone  (ISO)
nevirapine  (ISO)
nickel atom  (ISO)
nitrofen  (EXP)
O-methyleugenol  (ISO)
ochratoxin A  (EXP)
okadaic acid  (ISO)
oleic acid  (ISO)
oleoyl-CoA  (ISO)
oltipraz  (ISO)
oxaliplatin  (EXP)
palmitoyl ethanolamide  (EXP)
palmitoyl-CoA  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
parathion-methyl  (ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorododecanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanesulfonamide  (ISO)
perfluoropentanoic acid  (ISO)
perfluoroundecanoic acid  (ISO)
phenanthrene  (ISO)
phenobarbital  (EXP,ISO)
phenylpropanolamine  (EXP)
phenytoin  (ISO)
PhIP  (ISO)
progesterone  (EXP,ISO)
propiconazole  (EXP)
prostaglandin A2  (ISO)
prostaglandin J2  (ISO)
pyrazines  (ISO)
pyrene  (ISO)
quercetin  (EXP,ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rifamycins  (ISO)
rimonabant  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
S-hexylglutathione  (ISO)
SB 431542  (ISO)
Sesamol  (EXP)
silicon dioxide  (EXP)
stavudine  (EXP)
stearoyl-CoA  (ISO)
streptozocin  (EXP)
sucrose  (EXP)
sulfluramid  (ISO)
sulforaphane  (EXP,ISO)
sunitinib  (EXP,ISO)
Sunset Yellow FCF  (ISO)
tamoxifen  (EXP)
tartrazine  (ISO)
tert-butyl ethyl ether  (EXP)
tetrachloromethane  (EXP)
tetrahydrothiophene  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
Thiotepa  (ISO)
topotecan  (EXP)
toremifene  (EXP)
triadimefon  (EXP)
trichloroethene  (EXP)
triclosan  (ISO)
Tris(1-aziridinyl)phosphine oxide  (ISO)
Tris(2,3-dibromopropyl) phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
urethane  (ISO)
usnic acid  (ISO)
valproic acid  (ISO)
xanthohumol  (ISO)
XAV939  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IBA,IDA,IEA,ISO)
extracellular exosome  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Rat ligandin mRNA molecular cloning and sequencing. Daniel V, etal., Arch Biochem Biophys 1983 Nov;227(1):266-71.
2. Genomic cloning and characterization of the rat glutathione S-transferase-A3-subunit gene. Fotouhi-Ardakani N and Batist G, Biochem J 1999 May 1;339 ( Pt 3):685-93.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Cloning of cDNAs from fetal rat liver encoding glutathione S-transferase Yc polypeptides. The Yc2 subunit is expressed in adult rat liver resistant to the hepatocarcinogen aflatoxin B1. Hayes JD, etal., J Biol Chem 1994 Aug 12;269(32):20707-17.
5. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
6. Genetic polymorphisms and the efficacy and toxicity of cisplatin-based chemotherapy in ovarian cancer patients. Khrunin AV, etal., Pharmacogenomics J. 2010 Feb;10(1):54-61. Epub 2009 Sep 29.
7. Mapping of glutathione transferase (GST) genes in the rat. Klinga-Levan K, etal., Hereditas 1993;119(3):285-96.
8. Site-specific arylation of rat glutathione s-transferase A1 and A2 by bromobenzene metabolites in vivo. Koen YM, etal., Chem Res Toxicol. 2006 Nov;19(11):1426-34.
9. Sunitinib Inhibits Breast Cancer Cell Proliferation by Inducing Apoptosis, Cell-cycle Arrest and DNA Repair While Inhibiting NF-κB Signaling Pathways. Korashy HM, etal., Anticancer Res. 2017 Sep;37(9):4899-4909. doi: 10.21873/anticanres.11899.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Age, gender and region-specific differences in drug metabolising enzymes in rat ocular tissues. Nakamura K, etal., Exp Eye Res. 2005 Dec;81(6):710-5. Epub 2005 Jun 20.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. Isoenzyme-specific up-regulation of glutathione transferase and aldo-keto reductase mRNA expression by dietary quercetin in rat liver. Odbayar TO, etal., Mol Cell Biochem. 2009 May;325(1-2):121-30. Epub 2009 Feb 4.
14. GSTA1, GSTO1 and GSTO2 gene polymorphisms in Italian asthma patients. Polimanti R, etal., Clin Exp Pharmacol Physiol. 2010 Aug;37(8):870-2. Epub 2010 Mar 30.
15. GOA pipeline RGD automated data pipeline
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Electrostatic association of glutathione transferase to the nuclear membrane. Evidence of an enzyme defense barrier at the nuclear envelope. Stella L, etal., J Biol Chem. 2007 Mar 2;282(9):6372-9. Epub 2006 Dec 30.
18. Glutathione S-transferase: genetics and role in toxicology. Strange RC, etal., Toxicol Lett 2000 Mar 15;112-113:357-63.
19. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
20. Identification and characterization of novel rat and human gonad-specific organic anion transporters. Suzuki T, etal., Mol Endocrinol 2003 Jul;17(7):1203-15. Epub 2003 Apr 3.
21. Construction and characterization of a plasmid containing complementary DNA to mRNA encoding the N-terminal amino acid sequence of the rat glutathione transferase Ya subunit. Taylor JB, etal., Biochem J 1984 Apr 1;219(1):223-31.
22. Rat liver glutathione S-transferases. Construction of a cDNA clone complementary to a Yc mRNA and prediction of the complete amino acid sequence of a Yc subunit. Telakowski-Hopkins CA, etal., J Biol Chem 1985 May 10;260(9):5820-5.
23. The Yc and Ya subunits of rat liver glutathione S-transferases are the products of separate genes. Tu CP, etal., J Biol Chem 1984 Aug 10;259(15):9434-9.
24. Expression of a cDNA encoding a rat liver glutathione S-transferase Ya subunit in Escherichia coli. Wang RW, etal., Arch Biochem Biophys 1989 Mar;269(2):536-43.
Additional References at PubMed
PMID:1953636   PMID:2186703   PMID:6325423   PMID:9084911   PMID:10677856   PMID:11152686   PMID:11851347   PMID:15035604   PMID:15489334   PMID:16624487   PMID:19056867   PMID:20606271  
PMID:21492153   PMID:23376485   PMID:23533145  


Genomics

Comparative Map Data
Gsta1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8931,199,887 - 31,216,606 (-)NCBIGRCr8
mRatBN7.2923,703,476 - 23,720,121 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl923,703,477 - 23,720,121 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx932,196,752 - 32,213,351 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0937,317,434 - 37,334,033 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0935,632,677 - 35,649,276 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0927,366,404 - 27,381,004 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl927,368,272 - 27,452,902 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0926,283,550 - 26,300,195 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4920,051,501 - 20,068,146 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1920,048,823 - 20,065,988 (-)NCBI
Celera921,278,681 - 21,295,265 (-)NCBICelera
Cytogenetic Map9q13NCBI
GSTA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38652,791,371 - 52,803,816 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl652,791,371 - 52,803,860 (-)EnsemblGRCh38hg38GRCh38
GRCh37652,656,169 - 52,668,614 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36652,764,347 - 52,776,616 (-)NCBINCBI36Build 36hg18NCBI36
Build 34652,764,347 - 52,776,616NCBI
Celera654,317,257 - 54,329,719 (-)NCBICelera
Cytogenetic Map6p12.2NCBI
HuRef652,486,923 - 52,499,385 (-)NCBIHuRef
CHM1_1652,658,375 - 52,670,789 (-)NCBICHM1_1
T2T-CHM13v2.0652,630,148 - 52,642,586 (-)NCBIT2T-CHM13v2.0

Variants

.
Variants in Gsta1
91 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:21
Count of miRNA genes:21
Interacting mature miRNAs:21
Transcripts:ENSRNOT00000018325
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70226Eae4Experimental allergic encephalomyelitis QTL 4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)9125661317Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9137999212Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9137999212Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9137999212Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9510982642921101Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9728325252283252Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)9895256053952560Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)91353377042791750Rat
724543Cm20Cardiac mass QTL 203.9heart mass (VT:0007028)calculated heart weight (CMO:0000073)91696139840594091Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92043051965430519Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)92213332249968732Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 5 5 5 1
Medium 1 8 43 32 13 32 4 5 25 23 30 11 4
Low 2 21 9 4 6 4 4 6 31 12 6 4
Below cutoff 12 12 4

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_031509 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC095904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF067442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF111160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF127460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF146746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC059128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC088127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ179398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209644 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218456 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218470 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218508 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219196 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219451 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226984 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229239 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  K01932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S72505 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X78848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000018325   ⟹   ENSRNOP00000018325
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl923,703,477 - 23,720,121 (-)Ensembl
Rnor_6.0 Ensembl927,436,258 - 27,452,902 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000077372   ⟹   ENSRNOP00000068639
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl923,705,078 - 23,720,121 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000085195   ⟹   ENSRNOP00000069606
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl927,368,272 - 27,447,877 (-)Ensembl
RefSeq Acc Id: NM_031509   ⟹   NP_113697
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8931,199,887 - 31,216,532 (-)NCBI
mRatBN7.2923,703,476 - 23,720,121 (-)NCBI
Rnor_6.0927,366,404 - 27,381,004 (-)NCBI
Rnor_5.0926,283,550 - 26,300,195 (-)NCBI
RGSC_v3.4920,051,501 - 20,068,146 (-)RGD
Celera921,278,681 - 21,295,265 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063266628   ⟹   XP_063122698
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8931,199,890 - 31,216,606 (-)NCBI
RefSeq Acc Id: NP_113697   ⟸   NM_031509
- UniProtKB: Q6LD92 (UniProtKB/Swiss-Prot),   P04904 (UniProtKB/Swiss-Prot),   B6DYP8 (UniProtKB/TrEMBL),   Q9JLX3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000018325   ⟸   ENSRNOT00000018325
RefSeq Acc Id: ENSRNOP00000069606   ⟸   ENSRNOT00000085195
RefSeq Acc Id: ENSRNOP00000068639   ⟸   ENSRNOT00000077372
RefSeq Acc Id: XP_063122698   ⟸   XM_063266628
- Peptide Label: isoform X1
Protein Domains
GST C-terminal   GST N-terminal

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2753 AgrOrtholog
BioCyc Gene G2FUF-28002 BioCyc
Ensembl Genes ENSRNOG00000013484 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055019812 UniProtKB/Swiss-Prot
  ENSRNOG00060015468 UniProtKB/Swiss-Prot
  ENSRNOG00065018491 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000018325 ENTREZGENE
  ENSRNOT00000018325.5 UniProtKB/Swiss-Prot
  ENSRNOT00000077372.2 UniProtKB/TrEMBL
  ENSRNOT00055033855 UniProtKB/Swiss-Prot
  ENSRNOT00060026502 UniProtKB/Swiss-Prot
  ENSRNOT00065031062 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1050.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutaredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6922234 IMAGE-MGC_LOAD
  IMAGE:7322480 IMAGE-MGC_LOAD
  IMAGE:7324340 IMAGE-MGC_LOAD
InterPro Glutathione-S-Trfase_C-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutathione-S-Trfase_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutathione_S-Trfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutathione_S-Trfase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GST_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GST_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24421 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:108659 IMAGE-MGC_LOAD
  MGC:112704 IMAGE-MGC_LOAD
  MGC:72773 IMAGE-MGC_LOAD
NCBI Gene 24421 ENTREZGENE
PANTHER GLUTATHIONE S-TRANSFERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLUTATHIONE S-TRANSFERASE A2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GST_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GST_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB GSTA1 RGD
PhenoGen Gsta1 PhenoGen
PRINTS GSTRNSFRASEA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GST_CTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GST_NTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013484 RatGTEx
  ENSRNOG00055019812 RatGTEx
  ENSRNOG00060015468 RatGTEx
  ENSRNOG00065018491 RatGTEx
Superfamily-SCOP SSF47616 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52833 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JTB1_RAT UniProtKB/TrEMBL
  B6DYP8 ENTREZGENE, UniProtKB/TrEMBL
  GSTA3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6LD92 ENTREZGENE
  Q9JLX3 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q6LD92 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Gsta1  glutathione S-transferase alpha 1  LOC108348061  glutathione S-transferase alpha-3  Data merged from RGD:11504935 737654 PROVISIONAL
2016-08-02 LOC108348061  glutathione S-transferase alpha-3      Symbol and Name status set to provisional 70820 PROVISIONAL
2009-10-22 Gsta1  glutathione S-transferase alpha 1  Gsta1  glutathione S-transferase A1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-11 Gsta1  glutathione S-transferase A1  Gsta1  glutathione S-transferase, alpha 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Gsta1  glutathione S-transferase, alpha 1  Gsta3  glutathione S-transferase A3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Gsta3  glutathione S-transferase A3      Symbol and Name updated 1299863 APPROVED
2004-09-10 Gsta5  glutathione S-transferase A5  Gsta1  glutathione S-transferase, alpha 1   Symbol and Name updated 1299863 APPROVED
2002-11-06 Gsta1  glutathione S-transferase, alpha 1     Glutathione-S-transferase, alpha type (Ya)  Name updated 625702 APPROVED
2002-06-10 Gsta1  Glutathione-S-transferase, alpha type (Ya)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in liver and fibroblast cells 70479
gene_process functions in converting fat soluble chemicals to water-soluble to inhibit build-up of hydrophobic compounds in adipose 70479
gene_product member of the alpha class of glutathione S-transferases 633003