Nr3c1 (nuclear receptor subfamily 3, group C, member 1) - Rat Genome Database

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Gene: Nr3c1 (nuclear receptor subfamily 3, group C, member 1) Rattus norvegicus
Analyze
Symbol: Nr3c1
Name: nuclear receptor subfamily 3, group C, member 1
RGD ID: 2741
Description: Enables several functions, including heat shock protein binding activity; receptor tyrosine kinase binding activity; and transcription coactivator activity. Involved in several processes, including cellular response to magnesium ion; positive regulation of macromolecule metabolic process; and response to glucocorticoid. Located in cytoplasm; dendritic spine; and postsynaptic density. Part of protein-containing complex. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Colocalizes with nucleus. Used to study several diseases, including asthma; congestive heart failure; hypertension; obesity; and type 2 diabetes mellitus. Biomarker of several diseases, including brain disease (multiple); end stage renal disease; muscular atrophy; polycystic ovary syndrome; and post-traumatic stress disorder. Human ortholog(s) of this gene implicated in several diseases, including anorexia nervosa; lung disease (multiple); major depressive disorder; obesity; and renal cell carcinoma. Orthologous to human NR3C1 (nuclear receptor subfamily 3 group C member 1); PARTICIPATES IN cortisol signaling pathway; forkhead class A signaling pathway; prednisolone pharmacodynamics pathway; INTERACTS WITH (+)-pilocarpine; (S)-nicotine; 1,4-dithiothreitol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Gcr; glucocorticoid receptor; GR; Grl; nuclear receptor subfamily 3 group C member 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Nr3c1em1Kuan  
Genetic Models: SD-Nr3c1em1Kuan
Is Marker For: QTLs:   Bp46   Bp47   Scl22   Sprol1  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21831,271,681 - 31,393,320 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1831,271,681 - 31,393,375 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1831,375,854 - 31,463,901 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01832,142,851 - 32,230,932 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01831,471,103 - 31,559,156 (-)NCBIRnor_WKY
Rnor_6.01831,728,373 - 32,704,022 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1831,728,373 - 31,749,647 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01832,347,227 - 32,348,480 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01831,408,742 - 31,442,725 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41832,371,496 - 32,459,145 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11832,406,765 - 32,494,411 (-)NCBI
Celera1830,905,394 - 30,993,522 (-)NCBICelera
RH 3.4 Map18442.9RGD
Cytogenetic Map18p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
46, XX Disorders of Sex Development  (ISO)
anorexia nervosa  (ISO)
asthma  (IDA,ISO)
atrial fibrillation  (ISO)
bipolar disorder  (ISO)
brain ischemia  (IEP)
Burns  (IDA,IEP)
cataract  (IMP)
chronic obstructive pulmonary disease  (ISO)
Cocaine-Related Disorders  (ISO)
congestive heart failure  (IMP)
coronary artery disease  (ISO)
Cushing Syndrome  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Edema  (IDA)
end stage renal disease  (IEP)
endometriosis  (ISO)
Endotoxemia  (IDA)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (IEP)
familial adenomatous polyposis 1  (ISO)
Fetal Growth Retardation  (IDA,IEP)
genetic disease  (ISO)
Glucocorticoid Receptor Deficiency  (ISO)
glucose metabolism disease  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
hypertension  (IMP,ISO)
hypokalemia  (ISO)
interstitial lung disease  (ISO)
lipoid nephrosis  (ISO)
lung disease  (IEP,ISO)
lung non-small cell carcinoma  (ISO)
lupus nephritis  (ISO)
major depressive disorder  (ISO)
Malocclusion  (IEP)
mental depression  (IEP,ISO)
mood disorder  (ISO)
muscular atrophy  (IEP)
nephrotic syndrome  (ISO)
nephrotic syndrome type 2  (ISO)
Neurodevelopmental Disorders  (ISO)
obesity  (IDA,ISO)
obstructive lung disease  (ISO)
obstructive sleep apnea  (ISO)
ocular hypertension  (ISO)
Perennial Allergic Rhinitis  (ISO)
polycystic ovary syndrome  (IEP)
post-traumatic stress disorder  (IEP)
primary biliary cholangitis  (ISO)
primary hyperaldosteronism  (ISS)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
psychotic disorder  (ISO)
pulmonary sarcoidosis  (ISO)
renal cell carcinoma  (ISO)
rheumatoid arthritis  (IEP)
schizophrenia  (ISO)
Sepsis  (IDA,ISO)
sinusitis  (ISO)
status epilepticus  (IEP)
Stroke  (IDA)
Transplant Rejection  (ISO)
type 2 diabetes mellitus  (IDA)
uveitis  (IEP)
visual epilepsy  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(-)-anisomycin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(3,4-dihydroxyphenyl)acetic acid  (ISO)
(S)-amphetamine  (ISO)
(S)-colchicine  (ISO)
(S)-nicotine  (EXP,ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2,3,4,7,8-Hexachlorodibenzofuran  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dithiothreitol  (EXP,ISO)
1-[2-(benzhydryloxy)ethyl]-4-(3-phenylpropyl)piperazine  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
1-bromopropane  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
11-deoxycorticosterone  (EXP,ISO)
11-deoxycortisol  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17alpha-hydroxyprogesterone  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2',4,4'-tetrachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-aminophenol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,4-Dimethylbenzaldehyde  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,5,6-trichloro-2-pyridinol  (ISO)
3,5,6-trichloropyridine-2-one  (ISO)
3,5-di-tert-Butyl-4-hydroxybenzaldehyde  (ISO)
3-methylcholanthrene  (EXP,ISO)
3-phenoxybenzoic acid  (ISO)
3alpha-hydroxy-5beta-pregnan-20-one  (ISO)
4'-hydroxydiclofenac  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrolein  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
agomelatine  (ISO)
albuterol  (ISO)
aldehydo-D-glucose  (ISO)
aldosterone  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amiodarone  (EXP)
amitriptyline  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic acid  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
atrazine  (EXP,ISO)
Aurin  (ISO)
avobenzone  (ISO)
aziridines  (ISO)
azoxystrobin  (ISO)
beclomethasone  (EXP,ISO)
benzbromarone  (EXP)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzoyl peroxide  (ISO)
betamethasone  (ISO)
betulin  (ISO)
bifenthrin  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
budesonide  (EXP,ISO)
butachlor  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (EXP,ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
caffeine  (EXP,ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
celecoxib  (EXP)
CGP 52608  (ISO)
chlorpromazine  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
ciclopirox  (ISO)
cidofovir anhydrous  (ISO)
ciglitazone  (ISO)
cisplatin  (ISO)
citalopram  (ISO)
clodronic acid  (ISO)
clofibrate  (EXP)
clotrimazole  (ISO)
clozapine  (ISO)
cobalt atom  (EXP)
cocaine  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
compound 48/80  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP,ISO)
corticotropin  (ISO)
cortisol  (EXP,ISO)
cortisone  (ISO)
cortivazol  (ISO)
coumestrol  (ISO)
Cuprizon  (EXP)
curcumin  (EXP,ISO)
cycloheximide  (EXP,ISO)
cyclosporin A  (ISO)
cyhalothrin  (ISO)
cypermethrin  (ISO)
D-glucose  (ISO)
daunorubicin  (ISO)
DDE  (EXP,ISO)
DDT  (ISO)
deflazacort  (ISO)
deguelin  (ISO)
dehydroepiandrosterone  (ISO)
desipramine  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloromethane  (ISO)
diclofenac  (ISO)
Dicyclohexyl phthalate  (ISO)
diethyl phthalate  (ISO)
Diisodecyl phthalate  (ISO)
diisopropyl fluorophosphate  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
dopamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
endrin  (ISO)
entinostat  (ISO)
enzacamene  (EXP)
ethanol  (EXP,ISO)
ethiofencarb  (ISO)
ethyl myristate  (ISO)
fenchone  (ISO)
fenpyroximate  (ISO)
fenvalerate  (EXP)
fludrocortisone  (ISO)
flumethasone  (ISO)
fluoranthene  (ISO)
fluoxetine  (EXP,ISO)
flutamide  (EXP,ISO)
fluticasone  (EXP,ISO)
folic acid  (EXP,ISO)
folpet  (ISO)
formaldehyde  (ISO)
formoterol fumarate  (ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
Fusarenone X  (ISO)
gamma-hexachlorocyclohexane  (EXP)
genistein  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
ginsenoside Re  (ISO)
glafenine  (EXP)
glucose  (ISO)
hexadecanoic acid  (ISO)
homovanillic acid  (ISO)
hydralazine  (ISO)
hydrogen cyanide  (ISO)
hydrogen peroxide  (ISO)
ibuprofen  (EXP,ISO)
idazoxan  (EXP)
irinotecan  (ISO)
isoquinolines  (ISO)
ketoconazole  (ISO)
L-1,4-dithiothreitol  (EXP,ISO)
L-ascorbic acid  (ISO)
L-ethionine  (EXP)
L-methionine  (ISO)
lamotrigine  (ISO)
Laurolactam  (ISO)
lead diacetate  (ISO)
lead(0)  (EXP,ISO)
lead(2+)  (EXP,ISO)
leflunomide  (EXP,ISO)
linuron  (EXP)
lipopolysaccharide  (EXP,ISO)
lithium atom  (EXP,ISO)
lithium chloride  (EXP)
lithium hydride  (EXP,ISO)
LY 379268  (EXP)
medroxyprogesterone acetate  (ISO)
melatonin  (EXP,ISO)
menadione  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
metformin  (ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
methoxychlor  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
methylprednisolone aceponate  (ISO)
methylseleninic acid  (ISO)
methyltestosterone  (EXP)
miconazole  (ISO)
mifepristone  (EXP,ISO)
mirex  (EXP)
mitomycin C  (ISO)
mitoxantrone  (ISO)
molybdate  (EXP)
mometasone furoate  (EXP,ISO)
Monobutylphthalate  (ISO)
morphine  (EXP)
N,O-dimethyltyramine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-butylbenzenesulfonamide  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nicotine  (EXP,ISO)
nimesulide  (EXP)
nitric oxide  (ISO)
okadaic acid  (ISO)
omeprazole  (EXP)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pararosaniline free base  (ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP,ISO)
Phenoxybenzamine  (ISO)
phenylbutazone  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
phenytoin  (EXP,ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phorone  (EXP)
phosgene  (ISO)
pirinixic acid  (EXP,ISO)
Polygodial  (EXP)
potassium chloride  (EXP)
potassium chromate  (ISO)
potassium cyanide  (ISO)
prednisolone  (ISO)
prednisone  (ISO)
prednylidene  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
progesterone  (EXP,ISO)
promegestone  (ISO)
propiconazole  (ISO)
propylparaben  (ISO)
protoporphyrin  (ISO)
puromycin  (ISO)
pyrimidifen  (ISO)
quercetin  (EXP,ISO)
raloxifene  (ISO)
reactive oxygen species  (ISO)
reserpine  (EXP)
resmethrin  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
rimonabant  (ISO)
rotenone  (ISO)
S-methyl methanethiosulfonate  (EXP)
Salmeterol xinafoate  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
SCH 23390  (ISO)
selenium atom  (ISO)
selenous acid  (ISO)
senecionine  (EXP)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
spiperone  (ISO)
spiroxamine  (ISO)
succimer  (ISO)
sulfasalazine  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
Tanshinone I  (ISO)
tauroursodeoxycholic acid  (EXP,ISO)
tebufenpyrad  (ISO)
tenofovir disoproxil fumarate  (ISO)
terbutaline  (ISO)
teriflunomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetramethrin  (ISO)
tetraphene  (EXP)
thifluzamide  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
thyroxine  (EXP)
titanium dioxide  (ISO)
tolcapone  (EXP)
tolterodine tartrate  (ISO)
tolylfluanid  (ISO)
topotecan  (EXP)
torcetrapib  (ISO)
triamcinolone  (ISO)
triamcinolone acetonide  (EXP,ISO)
tributyl phosphate  (ISO)
Tributyltin oxide  (EXP)
trichloroethene  (EXP,ISO)
trichostatin A  (EXP,ISO)
trifluoperazine  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP,ISO)
triptonide  (ISO)
Tris(2-ethylhexyl) phosphate  (ISO)
troglitazone  (ISO)
trovafloxacin  (EXP)
undecan-2-one  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP,ISO)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
venlafaxine hydrochloride  (EXP)
verapamil  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zearalenone  (ISO)
zidovudine  (ISO)
zinc atom  (EXP,ISO)
zinc oxide  (ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal gland development  (IEA,ISO)
aging  (IEP)
androgen metabolic process  (IEP)
astrocyte differentiation  (IEA,ISO)
brain development  (IEP)
cellular response to dexamethasone stimulus  (IEA,IMP,ISO)
cellular response to glucocorticoid stimulus  (ISO,ISS)
cellular response to magnesium ion  (IEP)
cellular response to steroid hormone stimulus  (ISO,ISS)
cellular response to transforming growth factor beta stimulus  (IEA,ISO)
chromatin organization  (IEA)
chromatin remodeling  (IMP)
circadian rhythm  (IEP)
DNA-templated transcription  (IEA)
female pregnancy  (IEP)
gene expression  (ISO)
glucocorticoid mediated signaling pathway  (IEA)
glucocorticoid metabolic process  (IEA,ISO)
glucocorticoid receptor signaling pathway  (IEA,ISO)
lung development  (IEP)
mammary gland duct morphogenesis  (IEA,ISO)
maternal behavior  (IEA,ISO)
microglia differentiation  (IEA,ISO)
motor behavior  (IEA,ISO)
muscle atrophy  (IEP)
negative regulation of apoptotic process  (IMP)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of glucocorticoid mediated signaling pathway  (ISO)
negative regulation of synaptic plasticity  (IMP)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
negative regulation of vascular permeability  (IMP)
neuroinflammatory response  (IEA,ISO)
positive regulation of cell growth involved in cardiac muscle cell development  (IMP)
positive regulation of dendritic spine development  (IMP)
positive regulation of glucocorticoid receptor signaling pathway  (IDA)
positive regulation of glutamate secretion  (IMP)
positive regulation of miRNA transcription  (IEA,ISO)
positive regulation of neuron apoptotic process  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IDA,IEA,IMP,ISO)
protein-containing complex assembly  (TAS)
regulation of cell population proliferation  (IDA)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of glucocorticoid biosynthetic process  (IEA,ISO)
regulation of gluconeogenesis  (IEA,ISO)
regulation of glucose metabolic process  (IMP)
regulation of transcription by RNA polymerase II  (IBA)
response to activity  (IEP)
response to arsenic-containing substance  (IDA)
response to calcium ion  (IEP)
response to corticosterone  (IEP)
response to dexamethasone  (IEP)
response to electrical stimulus  (IEP)
response to inactivity  (IEP)
response to insulin  (IEP)
response to mercury ion  (IEP)
response to radiation  (IEP)
synaptic transmission, glutamatergic  (IEA,ISO)
transcription initiation-coupled chromatin remodeling  (IMP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. GR and HMGB1 interact only within chromatin and influence each other's residence time. Agresti A, etal., Mol Cell. 2005 Apr 1;18(1):109-21.
2. Interaction of the putative androgen receptor-specific coactivator ARA70/ELE1alpha with multiple steroid receptors and identification of an internally deleted ELE1beta isoform. Alen P, etal., Mol Endocrinol. 1999 Jan;13(1):117-28. doi: 10.1210/mend.13.1.0214.
3. The growth-inhibitory effects of dexamethasone on renal cell carcinoma in vivo and in vitro. Arai Y, etal., Cancer Invest. 2008 Feb;26(1):35-40.
4. Association of the glucocorticoid receptor with STAT3, C/EBPbeta, and the hormone-responsive element within the rat haptoglobin gene promoter during the acute phase response. Arambasic J, etal., IUBMB Life. 2010 Mar;62(3):227-36.
5. FMS-like tyrosine kinase 3 interacts with the glucocorticoid receptor complex and affects glucocorticoid dependent signaling. Asadi A, etal., Biochem Biophys Res Commun. 2008 Apr 11;368(3):569-74. Epub 2008 Feb 7.
6. Mineralocorticoid and glucocorticoid receptors stimulate epithelial sodium channel activity in a mouse model of Cushing syndrome. Bailey MA, etal., Hypertension. 2009 Oct;54(4):890-6. Epub 2009 Jul 27.
7. Changes of glucocorticoid receptor mRNA expression in basolateral amygdale-kindled rats. Bao GS, etal., Chin Med J (Engl). 2011 Sep;124(17):2622-7.
8. Uteroplacental insufficiency alters nephrogenesis and downregulates cyclooxygenase-2 expression in a model of IUGR with adult-onset hypertension. Baserga M, etal., Am J Physiol Regul Integr Comp Physiol. 2007 May;292(5):R1943-55. Epub 2007 Feb 1.
9. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
10. FoxA1 and glucocorticoid receptor crosstalk via histone H4K16 acetylation at a hormone regulated enhancer. Belikov S, etal., Exp Cell Res. 2012 Jan 1;318(1):61-74. Epub 2011 Oct 6.
11. Alpha glucocorticoid receptor expression in different experimental rat models of acute lung injury. Bertorelli G, etal., Pulm Pharmacol Ther. 2008;21(1):214-21. Epub 2007 Mar 24.
12. [Effect of magnesium-free on glucocorticoid receptor expression in primary cultured cortical neurons of fetal rats in vitro]. Bo T, etal., Zhongguo Dang Dai Er Ke Za Zhi. 2010 Mar;12(3):211-4.
13. Arsenic at very low concentrations alters glucocorticoid receptor (GR)-mediated gene activation but not GR-mediated gene repression: complex dose-response effects are closely correlated with levels of activated GR and require a functional GR DNA binding domain. Bodwell JE, etal., Chem Res Toxicol 2004 Aug;17(8):1064-76.
14. The aldosterone-mineralocorticoid receptor pathway exerts anti-inflammatory effects in endotoxin-induced uveitis. Bousquet E, etal., PLoS One. 2012;7(11):e49036. doi: 10.1371/journal.pone.0049036. Epub 2012 Nov 9.
15. Interaction of rat renal glucocorticoid receptor with Hsp90 and Hsp70 upon stress provoked by mercury. Brkljacic J, etal., J Appl Toxicol. 2007 Jan-Feb;27(1):43-50.
16. Glucocorticoid receptor auto-upregulation and its relation with glucocorticoid sensitivity in idiopathic nephrotic syndrome. Chen P, etal., Int Urol Nephrol. 2011 Mar;43(1):167-74. Epub 2010 Apr 24.
17. The Mediator subunit MED1/TRAP220 is required for optimal glucocorticoid receptor-mediated transcription activation. Chen W and Roeder RG, Nucleic Acids Res. 2007;35(18):6161-9. Epub 2007 Sep 7.
18. Glucocorticoid receptor gene polymorphisms associated with progression of lung disease in young patients with cystic fibrosis. Corvol H, etal., Respir Res. 2007 Nov 29;8:88.
19. Hyperthermic stress stimulates the association of both constitutive and inducible isoforms of 70 kDa heat shock protein with rat liver glucocorticoid receptor. Cvoro A and Matic G, Int J Biochem Cell Biol 2002 Mar;34(3):279-85.
20. Glucocorticoid receptor in active pulmonary sarcoidosis. de Carvalho CR, etal., Sarcoidosis. 1990 Sep;7(2):93-5.
21. Inhibition of glucocorticoid receptor binding by nitric oxide in endotoxemic rats. Duma D, etal., Crit Care Med. 2004 Nov;32(11):2304-10.
22. Modeling corticosteroid effects in a rat model of rheumatoid arthritis I: mechanistic disease progression model for the time course of collagen-induced arthritis in Lewis rats. Earp JC, etal., J Pharmacol Exp Ther. 2008 Aug;326(2):532-45. Epub 2008 Apr 30.
23. Glucocorticoid-mediated suppression of cytokine-induced matrix metalloproteinase-9 expression in rat mesangial cells: involvement of nuclear factor-kappaB and Ets transcription factors. Eberhardt W, etal., Mol Endocrinol. 2002 Aug;16(8):1752-66.
24. Occlusal disharmony increases amyloid-beta in the rat hippocampus. Ekuni D, etal., Neuromolecular Med. 2011 Sep;13(3):197-203. Epub 2011 Jul 13.
25. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
26. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
27. Glucocorticoid receptor subunit expression in adenotonsillar tissue of children with obstructive sleep apnea. Goldbart AD, etal., Pediatr Res. 2005 Feb;57(2):232-6. Epub 2004 Dec 20.
28. The cardiac K+ channel KCNQ1 is essential for gastric acid secretion. Grahammer F, etal., Gastroenterology. 2001 May;120(6):1363-71.
29. Glomerular glucocorticoid receptor expression is reduced in late responders to steroids in adult-onset minimal change disease. Han SH, etal., Nephrol Dial Transplant. 2008 Jan;23(1):169-75. Epub 2007 Sep 22.
30. [Effect of glucocorticoid on glucocorticoid-resistant children with primary nephrotic syndrome]. He XJ, etal., Zhonghua Er Ke Za Zhi. 2005 Feb;43(2):109-12.
31. Proteomic identification of glucocorticoid receptor interacting proteins. Hedman E, etal., Proteomics. 2006 May;6(10):3114-26.
32. BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation. Hsiao PW, etal., Mol Cell Biol. 2003 Sep;23(17):6210-20.
33. Differences in binding of glucocorticoid receptor to DNA in chronic renal graft rejection. Ichimaru N, etal., Transpl Int. 2000;13(4):255-9.
34. Glucocorticoid receptors in anorexia nervosa and Cushing's disease. Invitti C, etal., Biol Psychiatry. 1999 Jun 1;45(11):1467-71.
35. Insulin modulates rat liver glucocorticoid receptor. Isenovic ER, etal., Acta Biol Hung. 2006 Mar;57(1):37-48.
36. Overexpression of glucocorticoid receptor-beta in severe allergic rhinitis. Ishida A, etal., Auris Nasus Larynx. 2010 Oct;37(5):584-8. Epub 2010 Feb 24.
37. Role of macrophage migration inhibitory factor in glucocorticoid release and glucocorticoid receptor function in rats. Jing L and Bu M, Ann Clin Lab Sci. 2011 Fall;41(1):14-9.
38. Mutations at positions 547-553 of rat glucocorticoid receptors reveal that hsp90 binding requires the presence, but not defined composition, of a seven-amino acid sequence at the amino terminus of the ligand binding domain. Kaul S, etal., J Biol Chem 2002 Sep 27;277(39):36223-32.
39. Intrauterine growth retardation affects expression and epigenetic characteristics of the rat hippocampal glucocorticoid receptor gene. Ke X, etal., Physiol Genomics. 2010 Jul 7;42(2):177-89. Epub 2010 Apr 13.
40. Androgens modulate glucocorticoid receptor mRNA, but not mineralocorticoid receptor mRNA levels, in the rat hippocampus. Kerr JE, etal., J Neuroendocrinol. 1996 Jun;8(6):439-47.
41. Corticosterone induces rapid spinogenesis via synaptic glucocorticoid receptors and kinase networks in hippocampus. Komatsuzaki Y, etal., PLoS One. 2012;7(4):e34124. Epub 2012 Apr 11.
42. Expression of glucocorticoid receptor and glucose transporter-1 during placental development in the diabetic rat. Korgun ET, etal., Folia Histochem Cytobiol. 2011;49(2):325-34.
43. Glucocorticoid receptor mRNA levels in bronchial epithelial cells of patients with COPD: influence of glucocorticoids. Korn SH, etal., Respir Med. 1998 Sep;92(9):1102-9.
44. Novel quantitative trait loci for blood pressure and related traits on rat chromosomes 1, 10, and 18. Kovacs P, etal., Biochem Biophys Res Commun 1997 Jun 18;235(2):343-8
45. Glucocorticoid receptor gene polymorphisms in premenopausal women with major depression. Krishnamurthy P, etal., Horm Metab Res. 2008 Mar;40(3):194-8. Epub 2008 Feb 4.
46. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
47. Glucocorticoid receptor expression in the cortex of the neonatal rat brain with and without focal cerebral ischemia. Lee BH, etal., Neonatology. 2007;91(1):12-9. Epub 2006 Nov 10.
48. Maternal undernutrition during late gestation induces fetal overexposure to glucocorticoids and intrauterine growth retardation, and disturbs the hypothalamo-pituitary adrenal axis in the newborn rat. Lesage J, etal., Endocrinology 2001 May;142(5):1692-702.
49. Expression of locus coeruleus mineralocorticoid receptor and glucocorticoid receptor in rats under single-prolonged stress. Li M, etal., Neurol Sci. 2011 Aug;32(4):625-31. Epub 2011 May 17.
50. [Effects of electromagnetic irradiation on glucocorticoid in serum and its receptor expression in rat hippocampus]. Li MQ, etal., Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2007 Apr;25(4):215-9.
51. [Effect of glucocorticoid receptor blockade on pulmonary and renal vascular permeability in scalded rats]. Lin H, etal., Zhonghua Zheng Xing Shao Shang Wai Ke Za Zhi. 1995 Mar;11(2):103-5.
52. Association of coronary artery disease with glucocorticoid receptor N363S variant. Lin RC, etal., Hypertension. 2003 Mar;41(3):404-7. Epub 2003 Feb 10.
53. Glucocorticoids improve renal responsiveness to atrial natriuretic peptide by up-regulating natriuretic peptide receptor-A expression in the renal inner medullary collecting duct in decompensated heart failure. Liu C, etal., J Pharmacol Exp Ther. 2011 Oct;339(1):203-9. Epub 2011 Jul 7.
54. Changes in glucocorticoid and mineralocorticoid receptors of liver and kidney cytosols after pathologic stress and its regulation in rats. Liu DH, etal., Crit Care Med. 2002 Mar;30(3):623-7.
55. [Effects of ginsenosides on hypothalamic-pituitary-adrenal function and brain-derived neurotrophic factor in rats exposed to chronic unpredictable mild stress]. Liu L, etal., Zhongguo Zhong Yao Za Zhi. 2011 May;36(10):1342-7.
56. [Role of glucocorticoid receptor and nuclear factor-kappaB in patients with stable chronic obstructive pulmonary disease]. Liu T, etal., Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2010 Apr;32(2):147-50. doi: 10.3881/j.issn.1000-503X.2010.02.004.
57. Steroid receptor heterodimerization demonstrated in vitro and in vivo. Liu W, etal., Proc Natl Acad Sci U S A. 1995 Dec 19;92(26):12480-4.
58. [Effects of a formula of components from Shengmai Powder on glucocorticoid receptor in rats after thermal injury]. Lu X, etal., Zhong Xi Yi Jie He Xue Bao. 2009 Feb;7(2):121-4.
59. Changes of GR and HSP70 and their relationships with secondary hepatic damage after severe trauma Luo D, etal., Zhonghua Gan Zang Bing Za Zhi 2002 Jun;10(3):231.
60. Alteration of cadherin in dexamethasone-induced cataract organ-cultured rat lens. Lyu J, etal., Invest Ophthalmol Vis Sci. 2003 May;44(5):2034-40.
61. Acute Stress, But not Corticosterone, Disrupts Short- and Long-Term Synaptic Plasticity in Rat Dorsal Subiculum Via Glucocorticoid Receptor Activation. Macdougall MJ and Howland JG, Cereb Cortex. 2012 Aug 23.
62. Functional variability in corticosteroid receptors is a major component of strain differences in fat deposition and metabolic consequences of enriched diets in rat. Marissal-Arvy N, etal., Metabolism. 2010 Aug 17.
63. Meta-analysis on the effect of the N363S polymorphism of the glucocorticoid receptor gene (GRL) on human obesity. Marti A, etal., BMC Med Genet. 2006 May 25;7:50.
64. Stress and glucocorticoids regulated corticotropin releasing factor in rat prefrontal cortex. Meng QY, etal., Mol Cell Endocrinol. 2011 Aug 6;342(1-2):54-63. Epub 2011 Jun 1.
65. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
66. Mineralocorticoid receptor antagonism attenuates cardiac hypertrophy and prevents oxidative stress in uremic rats. Michea L, etal., Hypertension. 2008 Aug;52(2):295-300. Epub 2008 Jun 30.
67. Genetic complementation of a glucocorticoid receptor deficiency by expression of cloned receptor cDNA. Miesfeld R, etal., Cell 1986 Aug 1;46(3):389-99.
68. Transcription factors in muscle atrophy caused by blocked neuromuscular transmission and muscle unloading in rats. Nordquist J, etal., Mol Med. 2007 Sep-Oct;13(9-10):461-70.
69. Glucocorticoid receptor interaction with TrkB promotes BDNF-triggered PLC-gamma signaling for glutamate release via a glutamate transporter. Numakawa T, etal., Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):647-52. doi: 10.1073/pnas.0800888106. Epub 2009 Jan 6.
70. Fluoroquinolones reduce carrageenan-induced edema in rats and the involvement of the glucocorticoid receptor system. Ogino H, etal., J Infect Chemother. 2009 Apr;15(2):113-7. Epub 2009 Apr 25.
71. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
72. Glucocorticoid receptor-glucocorticoid response element binding stimulates nucleosome disruption by the SWI/SNF complex. Ostlund Farrants AK, etal., Mol Cell Biol 1997 Feb;17(2):895-905.
73. Stress-induced activation of ovarian heat shock protein 90 in a rat model of polycystic ovary syndrome. Park E, etal., J Obstet Gynaecol Res. 2012 Feb;38(2):396-407. doi: 10.1111/j.1447-0756.2011.01705.x. Epub 2011 Dec 19.
74. Changes of cytosol glucocorticoid receptor and renal Na(+)-K(+)-ATPase activity after swimming training in rat. Peijie B, etal., J Sports Med Phys Fitness. 2007 Jun;47(2):246-9.
75. A putative role for hypothalamic glucocorticoid receptors in hypertension induced by prenatal undernutrition in the rat. Perez H, etal., Neurosci Lett. 2010 Oct 8;483(1):41-6. Epub 2010 Jul 30.
76. Modulation of glucocorticoid receptor function and expression in adolescent moderate asthma. Perisic T, etal., Respiration. 2009;77(1):70-5. Epub 2008 Sep 18.
77. The Bcl I single nucleotide polymorphism of the human glucocorticoid receptor gene h-GR/NR3C1 promoter in patients with bronchial asthma: pilot study. Pietras T, etal., Mol Biol Rep. 2010 Nov 27.
78. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
79. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
80. Localization of mineralocorticoid receptors at mammalian synapses. Prager EM, etal., PLoS One. 2010 Dec 15;5(12):e14344.
81. Chaperoning of glucocorticoid receptors. Pratt WB, etal., Handb Exp Pharmacol. 2006;(172):111-38.
82. Dual role for glucocorticoids in cardiomyocyte hypertrophy and apoptosis. Ren R, etal., Endocrinology. 2012 Nov;153(11):5346-60. doi: 10.1210/en.2012-1563. Epub 2012 Sep 18.
83. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
84. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
85. Dysfunctional interaction of C/EBPalpha and the glucocorticoid receptor in asthmatic bronchial smooth-muscle cells. Roth M, etal., N Engl J Med. 2004 Aug 5;351(6):560-74.
86. Metabolic gene expression changes in the hippocampus of obese epileptic male rats in the pilocarpine model of temporal lobe epilepsy. Ruiz N, etal., Brain Res. 2011 Dec 2;1426:86-95. Epub 2011 Oct 8.
87. Changes in the pulmonary glucocorticoid receptor content in the course of interstitial disease. Saldiva PH, etal., Chest. 1985 Sep;88(3):417-9.
88. Modeling glucocorticoid-mediated fetal lung maturation: II. Temporal patterns of gene expression in fetal rat lung. Samtani MN, etal., J Pharmacol Exp Ther. 2006 Apr;317(1):127-38. Epub 2005 Dec 21.
89. Synthesized glucocorticoid, dexamethasone regulates the expressions of beta-adrenoceptor and glucocorticoid receptor mRNAs but not proteins in slow-twitch soleus muscle of rats. Sato S, etal., J Toxicol Sci. 2011;36(4):479-86.
90. Casted-immobilization downregulates glucocorticoid receptor expression in rat slow-twitch soleus muscle. Sato S, etal., Life Sci. 2011 Dec 19;89(25-26):962-7. Epub 2011 Oct 20.
91. [Effects of medicinal extract for tonifying kidney to relieve asthma on glucocorticoid receptor expression in lung tissues of rats with bronchial asthma]. Shi KH, etal., Zhong Xi Yi Jie He Xue Bao. 2010 Aug;8(8):785-9.
92. Localization of the glucocorticoid receptor mRNA in cartilage and bone cells of the rat. An in situ hybridization study. Silvestrini G, etal., Eur J Histochem. 2003;47(3):245-52.
93. Nuclear translocation of UDCA by the glucocorticoid receptor is required to reduce TGF-beta1-induced apoptosis in rat hepatocytes. Sola S, etal., Hepatology. 2005 Oct;42(4):925-34.
94. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
95. Successful treatment of acute lung injury with pitavastatin in septic mice: potential role of glucocorticoid receptor expression in alveolar macrophages. Takano K, etal., J Pharmacol Exp Ther. 2011 Feb;336(2):381-90. Epub 2010 Nov 5.
96. Upregulation of hepatic 11beta-hydroxysteroid dehydrogenase-1 expression in calcium-deficient rats. Takaya J, etal., Ann Nutr Metab. 2011;59(2-4):73-8. Epub 2011 Dec 2.
97. Importin 13 regulates nuclear import of the glucocorticoid receptor in airway epithelial cells. Tao T, etal., Am J Respir Cell Mol Biol. 2006 Dec;35(6):668-80. Epub 2006 Jun 29.
98. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
99. A pilot study exploring the role of glucocorticoid receptor variants in primary biliary cirrhosis and primary sclerosing cholangitis. ter Borg PC, etal., Neth J Med. 2004 Oct;62(9):326-31.
100. Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety. Tronche F, etal., Nat Genet. 1999 Sep;23(1):99-103.
101. Reduction in glucocorticoid receptors in renal biopsies of patients with lupus nephritis. Tziraki AA, etal., Clin Biochem. 2007 Nov;40(16-17):1188-93. Epub 2007 Aug 21.
102. Enhanced glucocorticoid receptor signaling in T cells impacts thymocyte apoptosis and adaptive immune responses. van den Brandt J, etal., Am J Pathol. 2007 Mar;170(3):1041-53.
103. Modulation of presynaptic glucocorticoid receptors on glutamate release from rat hippocampal nerve terminals. Wang CC and Wang SJ, Synapse. 2009 Sep;63(9):745-51.
104. [Effects of neonatal recurrent seizures on glucocorticoid receptor expression in the rat brain]. Wang TM, etal., Zhongguo Dang Dai Er Ke Za Zhi. 2010 Jan;12(1):47-50.
105. Changes of glucocorticoid receptor expression in the nasal polyps of patients with chronic sinusitis following treatment with glucocorticoid. Watanabe S and Suzaki H, In Vivo. 2008 Jan-Feb;22(1):37-42.
106. Cytosolic glucocorticoid receptor interaction with nuclear factor-kappa B proteins in rat liver cells. Widen C, etal., Biochem J. 2003 Jul 1;373(Pt 1):211-20.
107. Roles of mineralocorticoid and glucocorticoid receptors in the regulation of progenitor proliferation in the adult hippocampus. Wong EY and Herbert J, Eur J Neurosci. 2005 Aug;22(4):785-92.
108. Effect of artemisinin combined with glucocorticoid on the expressions of glucocorticoid receptor alpha mRNA, glucocorticoid receptor beta mRNA and P300/CBP protein in lupus nephritis mice. Wu XL, etal., Chin J Integr Med. 2011 Apr;17(4):277-82. Epub 2011 Apr 21.
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110. Expression of the glucocorticoid receptor in renal cell neoplasms: an immunohistochemical and quantitative reverse transcriptase polymerase chain reaction study. Yakirevich E, etal., Hum Pathol. 2011 Nov;42(11):1684-92. Epub 2011 Apr 29.
111. Modeling circadian rhythms of glucocorticoid receptor and glutamine synthetase expression in rat skeletal muscle. Yao Z, etal., Pharm Res. 2006 Apr;23(4):670-9. Epub 2006 Feb 2.
112. Glucocorticoid receptor changes associate with age in the paraventricular nucleus of type II diabetic rat model. Yi SS, etal., Neurochem Res. 2009 May;34(5):851-8. Epub 2008 Aug 29.
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Genomics

Comparative Map Data
Nr3c1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21831,271,681 - 31,393,320 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1831,271,681 - 31,393,375 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1831,375,854 - 31,463,901 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01832,142,851 - 32,230,932 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01831,471,103 - 31,559,156 (-)NCBIRnor_WKY
Rnor_6.01831,728,373 - 32,704,022 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1831,728,373 - 31,749,647 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01832,347,227 - 32,348,480 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01831,408,742 - 31,442,725 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41832,371,496 - 32,459,145 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11832,406,765 - 32,494,411 (-)NCBI
Celera1830,905,394 - 30,993,522 (-)NCBICelera
RH 3.4 Map18442.9RGD
Cytogenetic Map18p11NCBI
NR3C1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385143,277,931 - 143,435,512 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl5143,277,931 - 143,435,512 (-)EnsemblGRCh38hg38GRCh38
GRCh375142,657,496 - 142,815,077 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365142,637,689 - 142,795,270 (-)NCBINCBI36Build 36hg18NCBI36
Build 345142,639,324 - 142,763,087NCBI
Celera5138,738,770 - 138,896,297 (-)NCBICelera
Cytogenetic Map5q31.3NCBI
HuRef5137,804,733 - 137,962,312 (-)NCBIHuRef
CHM1_15142,091,205 - 142,248,804 (-)NCBICHM1_1
T2T-CHM13v2.05143,809,293 - 143,966,896 (-)NCBIT2T-CHM13v2.0
Nr3c1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391839,543,598 - 39,652,485 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1839,543,598 - 39,652,474 (-)EnsemblGRCm39 Ensembl
GRCm381839,410,545 - 39,519,421 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1839,410,545 - 39,519,421 (-)EnsemblGRCm38mm10GRCm38
MGSCv371839,570,199 - 39,646,899 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361839,537,961 - 39,615,820 (-)NCBIMGSCv36mm8
Celera1840,761,405 - 40,838,026 (-)NCBICelera
Cytogenetic Map18B3NCBI
cM Map1821.09NCBI
Nr3c1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541510,494,640 - 10,586,221 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541510,494,704 - 10,585,778 (+)NCBIChiLan1.0ChiLan1.0
NR3C1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15144,741,452 - 144,865,341 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5144,741,452 - 144,865,269 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05138,634,278 - 139,089,171 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
NR3C1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1238,124,568 - 38,242,510 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl238,123,190 - 38,240,755 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha235,173,176 - 35,283,390 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0238,573,084 - 38,692,463 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl238,573,084 - 38,690,726 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1235,654,977 - 35,765,222 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0236,468,553 - 36,579,023 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0237,270,194 - 37,380,458 (-)NCBIUU_Cfam_GSD_1.0
Nr3c1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213149,386,116 - 149,482,864 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650410,959,192 - 11,056,856 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493650410,960,069 - 11,056,834 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NR3C1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2144,822,939 - 144,956,451 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12144,822,937 - 144,956,451 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22151,051,816 - 151,185,046 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NR3C1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12345,904,926 - 46,031,804 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2345,904,873 - 46,031,125 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603431,810,840 - 31,935,849 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nr3c1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247742,495,304 - 2,602,632 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247742,496,276 - 2,603,894 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nr3c1
357 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1042
Count of miRNA genes:348
Interacting mature miRNAs:478
Transcripts:ENSRNOT00000019409, ENSRNOT00000044287
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18134291613Rat
2293661Bss50Bone structure and strength QTL 504.640.0003lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)18134291613Rat
61388Bp2Blood pressure QTL 23.23arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)18135374722Rat
9589153Insul31Insulin level QTL 317.150.05blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)18142547119Rat
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18420794160377792Rat
2312568Glom21Glomerulus QTL 2120.005kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)18518585840503530Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181179151863636873Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
61382Bp46Blood pressure QTL 4618.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194179131393320Rat
631264Scl22Serum cholesterol level QTL 226.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)181194179131393320Rat
1331766Bp236Blood pressure QTL 2363.022arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181194429931359530Rat
61375Bp41Blood pressure QTL 412.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)181194429941122201Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194429952293055Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)181194429959330563Rat
6903359Bp355Blood pressure QTL 3553.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194454459796478Rat
2313082Bss85Bone structure and strength QTL 850.80.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)181495133759951337Rat
1358193Emca2Estrogen-induced mammary cancer QTL 21.6mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)181800759963571040Rat
1331735Rf44Renal function QTL 442.981urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)181823456431359530Rat
1331775Bp235Blood pressure QTL 2353.201arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181823456431359530Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181927890183218561Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
1641923Colcr8Colorectal carcinoma resistance QTL 83.10.0014intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)182206624252293055Rat
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182479697779788953Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182557098570570985Rat
12904673Cm127Cardiac mass QTL 1270.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)182654808246969551Rat
12904675Am19Aortic mass QTL 190.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)182654808246969551Rat
12904677Kidm72Kidney mass QTL 720.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)182654808246969551Rat
12904668Bw188Body weight QTL 1880.03body mass (VT:0001259)body weight (CMO:0000012)182654808246969551Rat
12904669Cm125Cardiac mass QTL 1250.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)182654808246969551Rat
12904670Cm126Cardiac mass QTL 1260.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)182654808246969551Rat
2301413Bp318Blood pressure QTL 3180.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182654808246969551Rat
2293704Bss35Bone structure and strength QTL 354.590.0002femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)182896485373964853Rat
2300157Bmd66Bone mineral density QTL 6613.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
2300177Bmd65Bone mineral density QTL 6519.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)182979296574792965Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)182979296574792965Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)182979296574792965Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182979296574792965Rat
738005Anxrr11Anxiety related response QTL 113.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)183003981375039813Rat
61383Bp47Blood pressure QTL 4717.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)183127168160377755Rat
1331742Bp228Blood pressure QTL 2283.88752arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
1331774Bp226Blood pressure QTL 2264.41065arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
1331776Bp225Blood pressure QTL 2252.829arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)183135940859796643Rat
1331798Bp224Blood pressure QTL 2243.53873arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
1331727Bp237Blood pressure QTL 2373.053arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940861698465Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183135940870263868Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183135940883218561Rat
6903347Bp350Blood pressure QTL 3504.4arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135953059796478Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183139332077209694Rat

Markers in Region
D18Mit5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21831,359,408 - 31,359,530 (+)MAPPERmRatBN7.2
Rnor_6.01832,670,352 - 32,670,473NCBIRnor6.0
Rnor_5.01832,348,154 - 32,348,275UniSTSRnor5.0
RGSC_v3.41832,458,819 - 32,458,940UniSTSRGSC3.4
RGSC_v3.11832,494,084 - 32,494,206RGD
Celera1830,993,196 - 30,993,317UniSTS
SHRSP x BN Map1817.1599RGD
SHRSP x BN Map1817.1599UniSTS
Cytogenetic Map18p12UniSTS
D18Wox8  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01832,348,153 - 32,348,275NCBIRnor5.0
RGSC_v3.41832,458,819 - 32,458,940UniSTSRGSC3.4
Celera1830,993,196 - 30,993,317UniSTS
RH 2.0 Map18490.0RGD
SHRSP x BN Map1817.1599UniSTS
AW529964  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21831,273,733 - 31,273,889 (+)MAPPERmRatBN7.2
Rnor_6.01831,730,426 - 31,730,581NCBIRnor6.0
Rnor_5.01831,410,795 - 31,410,950UniSTSRnor5.0
RGSC_v3.41832,373,549 - 32,373,704UniSTSRGSC3.4
Celera1830,907,447 - 30,907,602UniSTS
RH 3.4 Map18442.7UniSTS
Cytogenetic Map18p12UniSTS
RH94419  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21831,275,219 - 31,275,372 (+)MAPPERmRatBN7.2
Rnor_6.01831,731,912 - 31,732,064NCBIRnor6.0
Rnor_5.01831,412,281 - 31,412,433UniSTSRnor5.0
RGSC_v3.41832,375,035 - 32,375,187UniSTSRGSC3.4
Celera1830,908,933 - 30,909,085UniSTS
RH 3.4 Map18442.9UniSTS
Cytogenetic Map18p12UniSTS
NR3C1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21831,358,829 - 31,359,293 (+)MAPPERmRatBN7.2
Rnor_6.01832,669,773 - 32,670,236NCBIRnor6.0
Rnor_5.01832,347,575 - 32,348,038UniSTSRnor5.0
RGSC_v3.41832,458,240 - 32,458,703UniSTSRGSC3.4
Celera1830,992,617 - 30,993,080UniSTS
Cytogenetic Map18p12UniSTS
D18Mit17  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21831,359,344 - 31,359,564 (+)MAPPERmRatBN7.2
Rnor_6.01832,670,288 - 32,670,507NCBIRnor6.0
Rnor_5.01832,348,090 - 32,348,309UniSTSRnor5.0
RGSC_v3.41832,458,755 - 32,458,974UniSTSRGSC3.4
Celera1830,993,132 - 30,993,351UniSTS
Cytogenetic Map18p12UniSTS


Genetic Models
This gene Nr3c1 is modified in the following models/strains

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 41 57 41 19 41 8 10 38 35 31 11 8
Low 2 1 36 10
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001408897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_012576 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008772065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096566 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB115420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC096226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC127951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC132058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF455050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ271870 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY066016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY293740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB699574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF495208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M14053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y00489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y12264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000044287   ⟹   ENSRNOP00000044335
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1831,271,681 - 31,359,735 (-)Ensembl
Rnor_6.0 Ensembl1831,728,373 - 31,749,647 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000094555   ⟹   ENSRNOP00000077321
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1831,349,007 - 31,362,168 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000103007   ⟹   ENSRNOP00000085495
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1831,351,407 - 31,393,375 (-)Ensembl
RefSeq Acc Id: NM_012576   ⟹   NP_036708
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21831,271,681 - 31,359,735 (-)NCBI
Rnor_6.01831,728,373 - 32,670,678 (-)NCBI
Rnor_5.01831,408,742 - 31,442,725 (-)NCBI
Rnor_5.01832,347,227 - 32,348,480 (-)NCBI
RGSC_v3.41832,371,496 - 32,459,145 (-)RGD
Celera1830,905,394 - 30,993,522 (-)RGD
Sequence:
RefSeq Acc Id: XM_008772065   ⟹   XP_008770287
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21831,273,365 - 31,362,278 (-)NCBI
Rnor_6.01831,728,373 - 32,672,969 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017600839   ⟹   XP_017456328
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21831,271,681 - 31,362,278 (-)NCBI
Rnor_6.01831,728,373 - 32,672,969 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017600840   ⟹   XP_017456329
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21831,275,610 - 31,361,837 (-)NCBI
Rnor_6.01831,728,373 - 32,672,787 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017600841   ⟹   XP_017456330
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21831,275,610 - 31,363,144 (-)NCBI
Rnor_6.01831,728,373 - 32,673,965 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017600843   ⟹   XP_017456332
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21831,275,610 - 31,393,320 (-)NCBI
Rnor_6.01831,728,373 - 32,704,022 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017600844   ⟹   XP_017456333
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21831,275,610 - 31,363,460 (-)NCBI
Rnor_6.01831,728,373 - 32,674,418 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039096566   ⟹   XP_038952494
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21831,272,716 - 31,363,143 (-)NCBI
RefSeq Acc Id: XM_039096567   ⟹   XP_038952495
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21831,275,610 - 31,362,278 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_036708   ⟸   NM_012576
- UniProtKB: P06536 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008770287   ⟸   XM_008772065
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017456332   ⟸   XM_017600843
- Peptide Label: isoform X1
- UniProtKB: E9PT44 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456333   ⟸   XM_017600844
- Peptide Label: isoform X1
- UniProtKB: E9PT44 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456330   ⟸   XM_017600841
- Peptide Label: isoform X1
- UniProtKB: E9PT44 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456328   ⟸   XM_017600839
- Peptide Label: isoform X1
- UniProtKB: E9PT44 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456329   ⟸   XM_017600840
- Peptide Label: isoform X1
- UniProtKB: E9PT44 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000044335   ⟸   ENSRNOT00000044287
RefSeq Acc Id: XP_038952494   ⟸   XM_039096566
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038952495   ⟸   XM_039096567
- Peptide Label: isoform X3
RefSeq Acc Id: ENSRNOP00000077321   ⟸   ENSRNOT00000094555
RefSeq Acc Id: ENSRNOP00000085495   ⟸   ENSRNOT00000103007
Protein Domains
NR LBD   Nuclear receptor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P06536-F1-model_v2 AlphaFold P06536 1-795 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2741 AgrOrtholog
BioCyc Gene G2FUF-7742 BioCyc
Ensembl Genes ENSRNOG00000014096 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000044335 ENTREZGENE
  ENSRNOP00000044335.5 UniProtKB/TrEMBL
  ENSRNOP00000077321.1 UniProtKB/TrEMBL
  ENSRNOP00000085495.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000044287 ENTREZGENE
  ENSRNOT00000044287.5 UniProtKB/TrEMBL
  ENSRNOT00000094555.1 UniProtKB/TrEMBL
  ENSRNOT00000103007.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.565.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.50.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Glcrtcd_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NHR-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucl_hrmn_rcpt_lig-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuclear_hrmn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_hrmn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_NHR/GATA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24413 UniProtKB/Swiss-Prot
NCBI Gene 24413 ENTREZGENE
PANTHER GLUCOCORTICOID RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KNIRPS-RELATED PROTEIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GCR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hormone_recep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-C4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB NR3C1 RGD
PhenoGen Nr3c1 PhenoGen
PRINTS GLCORTICOIDR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STRDHORMONER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STROIDFINGER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NR_LBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HOLI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnF_C4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48508 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC216596
UniProt A0A8I6A088_RAT UniProtKB/TrEMBL
  E9PT44 ENTREZGENE, UniProtKB/TrEMBL
  GCR_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary O08624 UniProtKB/Swiss-Prot
  Q8R463 UniProtKB/Swiss-Prot
  Q8R5J0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Nr3c1  nuclear receptor subfamily 3, group C, member 1  Grl  glucocorticoid receptor  Symbol and Name updated 629477 APPROVED
2002-06-10 Grl  glucocorticoid receptor      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function binds to glucocorticoid, ligand-activated transcription factor 61055
gene_function binds to glucocorticoid, ligand-activated transcription factor 68694
gene_physical_interaction forms heterocomplexes with heat shock proteins Hsp90 and Hsp70 729398
gene_protein 795 amino acids residues 728978
gene_transcript contains 12 variable exons and eight constant exons 1302827