Gnmt (glycine N-methyltransferase) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Gnmt (glycine N-methyltransferase) Rattus norvegicus
Analyze
Symbol: Gnmt
Name: glycine N-methyltransferase
RGD ID: 2719
Description: Enables several functions, including S-adenosyl-L-methionine binding activity; carboxylic acid binding activity; and glycine N-methyltransferase activity. Involved in S-adenosylmethionine metabolic process; alpha-amino acid metabolic process; and protein homotetramerization. Located in cytosol. Part of methyltransferase complex. Human ortholog(s) of this gene implicated in glycine N-methyltransferase deficiency. Orthologous to human GNMT (glycine N-methyltransferase); PARTICIPATES IN homocysteine metabolic pathway; methionine cycle/metabolic pathway; dihydropyrimidine dehydrogenase deficiency pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: folate-binding protein; glycine methyltransferase; glycine N-methyltransferase-like; LOC100911564
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8921,752,235 - 21,756,368 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl921,752,266 - 21,755,692 (+)EnsemblGRCr8
mRatBN7.2914,254,675 - 14,258,028 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl914,254,675 - 14,258,434 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx922,837,543 - 22,840,774 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0927,901,607 - 27,904,956 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0926,200,917 - 26,204,148 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0916,565,274 - 16,568,626 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl916,565,225 - 16,568,627 (+)Ensemblrn6Rnor6.0
Rnor_5.0915,471,889 - 15,475,241 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4910,127,092 - 10,130,444 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera912,003,123 - 12,006,473 (+)NCBICelera
RGSC_v3.1910,124,413 - 10,127,766 (+)NCBI
Cytogenetic Map9q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2-nitrofluorene  (EXP)
2-palmitoylglycerol  (ISO)
3-chloropropane-1,2-diol  (EXP,ISO)
3-methylcholanthrene  (EXP,ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-methyltetrahydrofolic acid  (EXP)
acetamide  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
aflatoxin M1  (ISO)
aflatoxin Q1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (EXP,ISO)
Aroclor 1254  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
cadmium dichloride  (EXP)
calcitriol  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
chloroprene  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clothianidin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
DDE  (ISO)
dexamethasone  (EXP)
dicrotophos  (ISO)
diquat  (ISO)
elemental selenium  (EXP)
endosulfan  (ISO)
enzalutamide  (ISO)
ethanol  (ISO)
fenofibrate  (ISO)
fenthion  (ISO)
finasteride  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (EXP,ISO)
fructose  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
gefitinib  (ISO)
genistein  (EXP,ISO)
glafenine  (EXP)
gliotoxin  (EXP)
GW 4064  (ISO)
indometacin  (EXP)
Lasiocarpine  (ISO)
leflunomide  (ISO)
MeIQx  (ISO)
metformin  (EXP)
methapyrilene  (EXP,ISO)
methidathion  (ISO)
methyl methanesulfonate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
naphthalene  (ISO)
nefazodone  (EXP)
nimesulide  (EXP)
nitrofen  (EXP)
Nutlin-3  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (EXP)
okadaic acid  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
phenformin  (EXP)
phenobarbital  (EXP)
PhIP  (ISO)
picoxystrobin  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
quercetin  (ISO)
rotenone  (EXP)
selenium atom  (EXP)
senecionine  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
streptozocin  (EXP)
sulindac  (EXP)
tebuconazole  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triazines  (ISO)
trichloroethene  (EXP,ISO)
triphenyl phosphate  (EXP,ISO)
Triptolide  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
vancomycin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IBA,IDA,IEA,ISO,TAS)
methyltransferase complex  (IMP)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. A review of methionine dependency and the role of methionine restriction in cancer growth control and life-span extension. Cavuoto P and Fenech MF, Cancer Treat Rev. 2012 Oct;38(6):726-36. doi: 10.1016/j.ctrv.2012.01.004. Epub 2012 Feb 17.
2. Glycine N-methyltransferase is a folate binding protein of rat liver cytosol. Cook RJ and Wagner C, Proc Natl Acad Sci U S A. 1984 Jun;81(12):3631-4. doi: 10.1073/pnas.81.12.3631.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Mechanisms for auto-inhibition and forced product release in glycine N-methyltransferase: crystal structures of wild-type, mutant R175K and S-adenosylhomocysteine-bound R175K enzymes. Huang Y, etal., J Mol Biol. 2000 Apr 21;298(1):149-62.
6. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
7. Proteomics reveal a concerted upregulation of methionine metabolic pathway enzymes, and downregulation of carbonic anhydrase-III, in betaine supplemented ethanol-fed rats. Kharbanda KK, etal., Biochem Biophys Res Commun. 2009 Apr 17;381(4):523-7. doi: 10.1016/j.bbrc.2009.02.082. Epub 2009 Feb 23.
8. S-adenosylmethionine in liver health, injury, and cancer. Lu SC and Mato JM, Physiol Rev. 2012 Oct;92(4):1515-42. doi: 10.1152/physrev.00047.2011.
9. Acetylation of N-terminal valine of glycine N-methyltransferase affects enzyme inhibition by folate. Luka Z, etal., Biochim Biophys Acta. 2008 Sep;1784(9):1342-6. doi: 10.1016/j.bbapap.2008.04.016. Epub 2008 May 2.
10. Differences in folate-protein interactions result in differing inhibition of native rat liver and recombinant glycine N-methyltransferase by 5-methyltetrahydrofolate. Luka Z, etal., Biochim Biophys Acta. 2012 Feb;1824(2):286-91. doi: 10.1016/j.bbapap.2011.10.008. Epub 2011 Oct 20.
11. 5-methyltetrahydrofolate is bound in intersubunit areas of rat liver folate-binding protein glycine N-methyltransferase. Luka Z, etal., J Biol Chem. 2007 Feb 9;282(6):4069-75. Epub 2006 Dec 7.
12. Activation and induction of glycine N-methyltransferase by retinoids are tissue- and gender-specific. McMullen MH, etal., Arch Biochem Biophys 2002 May 1;401(1):73-80.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. Modulation of methyl group metabolism by streptozotocin-induced diabetes and all-trans-retinoic acid. Nieman KM, etal., J Biol Chem 2004 Oct 29;279(44):45708-12. Epub 2004 Aug 30.
16. Rat glycine methyltransferase. Complete amino acid sequence deduced from a cDNA clone and characterization of the genomic DNA. Ogawa H, etal., Eur J Biochem 1987 Oct 1;168(1):141-51.
17. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
18. Glycine N-methyltransferases: a comparison of the crystal structures and kinetic properties of recombinant human, mouse and rat enzymes. Pakhomova S, etal., Proteins. 2004 Nov 1;57(2):331-7.
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
21. GOA pipeline RGD automated data pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Vitamin A and its derivatives induce hepatic glycine N-methyltransferase and hypomethylation of DNA in rats. Rowling MJ, etal., J Nutr 2002 Mar;132(3):365-9.
25. Tissue distribution of glycine N-methyltransferase, a major folate-binding protein of liver. Yeo EJ and Wagner C, Proc Natl Acad Sci U S A 1994 Jan 4;91(1):210-4.
Additional References at PubMed
PMID:8810903   PMID:9655336   PMID:14608049   PMID:16189514   PMID:17937387   PMID:21445860   PMID:25336395   PMID:25502805   PMID:26871637   PMID:31515488  


Genomics

Comparative Map Data
Gnmt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8921,752,235 - 21,756,368 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl921,752,266 - 21,755,692 (+)EnsemblGRCr8
mRatBN7.2914,254,675 - 14,258,028 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl914,254,675 - 14,258,434 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx922,837,543 - 22,840,774 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0927,901,607 - 27,904,956 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0926,200,917 - 26,204,148 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0916,565,274 - 16,568,626 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl916,565,225 - 16,568,627 (+)Ensemblrn6Rnor6.0
Rnor_5.0915,471,889 - 15,475,241 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4910,127,092 - 10,130,444 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera912,003,123 - 12,006,473 (+)NCBICelera
RGSC_v3.1910,124,413 - 10,127,766 (+)NCBI
Cytogenetic Map9q12NCBI
GNMT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38642,960,754 - 42,963,880 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl642,960,754 - 42,963,880 (+)Ensemblhg38GRCh38
GRCh37642,928,492 - 42,931,618 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36643,036,478 - 43,039,596 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34643,036,477 - 43,039,595NCBI
Celera644,480,758 - 44,483,869 (+)NCBICelera
Cytogenetic Map6p21.1NCBI
HuRef642,645,801 - 42,648,911 (+)NCBIHuRef
CHM1_1642,930,969 - 42,934,095 (+)NCBICHM1_1
T2T-CHM13v2.0642,789,900 - 42,793,018 (+)NCBIT2T-CHM13v2.0
Gnmt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391747,036,590 - 47,040,091 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1747,036,590 - 47,040,094 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381746,725,664 - 46,729,211 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1746,725,664 - 46,729,168 (-)Ensemblmm10GRCm38
MGSCv371746,862,613 - 46,866,114 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361746,188,855 - 46,192,356 (-)NCBIMGSCv36mm8
Celera1750,161,350 - 50,164,841 (-)NCBICelera
Cytogenetic Map17CNCBI
cM Map1722.9NCBI
Gnmt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554378,944,047 - 8,946,642 (+)Ensembl
ChiLan1.0NW_0049554378,944,288 - 8,946,642 (+)NCBIChiLan1.0ChiLan1.0
GNMT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2557,453,015 - 57,462,242 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1653,326,193 - 53,342,571 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0642,550,631 - 42,554,385 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1643,846,560 - 43,849,679 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl643,846,560 - 43,849,679 (+)EnsemblpanPan2panpan1.1
GNMT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11211,500,363 - 11,503,075 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1211,500,392 - 11,503,481 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1211,527,380 - 11,530,090 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01211,981,562 - 11,984,272 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1211,981,589 - 11,984,224 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11211,509,980 - 11,512,694 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01211,594,281 - 11,596,795 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01211,688,299 - 11,691,025 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gnmt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494646,995,031 - 46,998,424 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647616,957,270 - 16,965,346 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647616,961,734 - 16,965,487 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GNMT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl738,038,358 - 38,041,217 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1738,038,359 - 38,041,218 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2743,486,726 - 43,489,585 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GNMT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11729,196,142 - 29,199,728 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1729,196,321 - 29,198,947 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604443,019,849 - 43,022,686 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Gnmt
36 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:73
Count of miRNA genes:68
Interacting mature miRNAs:70
Transcripts:ENSRNOT00000022307
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9534647950346479Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9875049253750492Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)9131250552Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)949664545496645Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9621499551214995Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9875049253750492Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9141763315Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9534647950416711Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9671488829567695Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)949664545496645Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)92103143049025574Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)949664545496645Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9621499551214995Rat

Markers in Region
D9Arb1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8158,095,827 - 58,096,319 (+)Marker Load Pipeline
Cytogenetic Map9q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
13 32 65 75 72 59 8 59 6 203 52 53 79 60 13 9 9

Sequence


Ensembl Acc Id: ENSRNOT00000022307   ⟹   ENSRNOP00000022307
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl921,752,268 - 21,755,634 (+)Ensembl
mRatBN7.2 Ensembl914,254,675 - 14,258,028 (+)Ensembl
Rnor_6.0 Ensembl916,565,225 - 16,568,627 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000072812   ⟹   ENSRNOP00000067671
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl921,752,266 - 21,755,692 (+)Ensembl
mRatBN7.2 Ensembl914,254,675 - 14,258,434 (+)Ensembl
Rnor_6.0 Ensembl916,314,173 - 16,317,413 (+)Ensembl
RefSeq Acc Id: NM_017084   ⟹   NP_058780
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8921,752,282 - 21,755,634 (+)NCBI
mRatBN7.2914,254,675 - 14,258,028 (+)NCBI
Rnor_6.0916,565,274 - 16,568,626 (+)NCBI
Rnor_5.0915,471,889 - 15,475,241 (+)NCBI
RGSC_v3.4910,127,092 - 10,130,444 (+)RGD
Celera912,003,123 - 12,006,473 (+)RGD
Sequence:
RefSeq Acc Id: XM_063266661   ⟹   XP_063122731
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8921,752,235 - 21,756,368 (+)NCBI
RefSeq Acc Id: NP_058780   ⟸   NM_017084
- UniProtKB: P13255 (UniProtKB/Swiss-Prot),   A6JIM7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000022307   ⟸   ENSRNOT00000022307
Ensembl Acc Id: ENSRNOP00000067671   ⟸   ENSRNOT00000072812
RefSeq Acc Id: XP_063122731   ⟸   XM_063266661
- Peptide Label: isoform X1
- UniProtKB: M0RDH0 (UniProtKB/TrEMBL)
Protein Domains
Methyltransferase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0RDH0-F1-model_v2 AlphaFold M0RDH0 1-293 view protein structure
AF-P13255-F1-model_v2 AlphaFold P13255 1-293 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696506
Promoter ID:EPDNEW_R7030
Type:multiple initiation site
Name:Gnmt_1
Description:glycine N-methyltransferase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0916,565,260 - 16,565,320EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2719 AgrOrtholog
BioCyc Gene G2FUF-28242 BioCyc
Ensembl Genes ENSRNOG00000016349 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00000048623 Ensembl
Ensembl Transcript ENSRNOT00000022307 ENTREZGENE
  ENSRNOT00000022307.5 UniProtKB/Swiss-Prot
  ENSRNOT00000072812 ENTREZGENE
Gene3D-CATH 3.40.50.150 UniProtKB/Swiss-Prot
  Glycine N-methyltransferase, chain A, domain 1 UniProtKB/Swiss-Prot
InterPro Gly/Sar_N_MeTrfase UniProtKB/Swiss-Prot
  Methyltransf_25 UniProtKB/Swiss-Prot
  SAM-dependent_MTases UniProtKB/Swiss-Prot
KEGG Report rno:25134 UniProtKB/Swiss-Prot
NCBI Gene 25134 ENTREZGENE
PANTHER GLYCINE N-METHYLTRANSFERASE UniProtKB/Swiss-Prot
  PTHR16458 UniProtKB/Swiss-Prot
Pfam Methyltransf_25 UniProtKB/Swiss-Prot
PhenoGen Gnmt PhenoGen
PIRSF Gly_N-mtase UniProtKB/Swiss-Prot
PROSITE SAM_GNMT UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000016349 RatGTEx
  ENSRNOG00000048623 RatGTEx
Superfamily-SCOP SSF53335 UniProtKB/Swiss-Prot
UniProt A6JIM7 ENTREZGENE, UniProtKB/TrEMBL
  A6JIM8_RAT UniProtKB/TrEMBL
  GNMT_RAT UniProtKB/Swiss-Prot
  M0RDH0 ENTREZGENE, UniProtKB/TrEMBL
  P13255 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Gnmt  glycine N-methyltransferase  LOC100911564  glycine N-methyltransferase-like  Data merged from RGD:6491825 737654 PROVISIONAL
2012-07-05 LOC100911564  glycine N-methyltransferase-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-09-10 Gnmt  glycine N-methyltransferase    glycine methyltransferase  Name updated 1299863 APPROVED
2002-06-10 Gnmt  Glycine methyltransferase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation increased enzyme levels and activity are induced by retinoid compounds specifically in liver and are not induced in other tissues 728472