Gnas (GNAS complex locus) - Rat Genome Database

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Gene: Gnas (GNAS complex locus) Rattus norvegicus
Analyze
Symbol: Gnas
Name: GNAS complex locus
RGD ID: 2716
Description: Enables several functions, including G-protein alpha-subunit binding activity; G-protein beta-subunit binding activity; and signaling receptor binding activity. Involved in several processes, including adenylate cyclase-activating dopamine receptor signaling pathway; cellular response to prostaglandin E stimulus; and positive regulation of sodium ion transport. Located in several cellular components, including cytoplasmic vesicle; ruffle; and sarcolemma. Part of heterotrimeric G-protein complex. Biomarker of polycystic kidney disease. Human ortholog(s) of this gene implicated in several diseases, including ACTH-independent macronodular adrenal hyperplasia 1; obesity; pituitary adenoma 3; progressive osseous heteroplasia; and pseudohypoparathyroidism (multiple). Orthologous to human GNAS (GNAS complex locus); PARTICIPATES IN G protein mediated signaling pathway via Galphas family; glucagon signaling pathway; vasopressin signaling pathway; INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: adenylate cyclase-stimulating G alpha protein; ALEX; G-alpha-8; GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus; GNAS complex locus XLas-like; Gnas1; Gnasxl; Gnpas; guanine nucleotide binding protein alpha s; guanine nucleotide binding protein alpha stimulating; guanine nucleotide binding protein alpha stimulating extra large; guanine nucleotide-binding protein G-s, alpha subunit; Guanine nucleotide-binding protein G-s, alpha subunit, Genbank no U51565; LOC100361691; LOC690994; Nesp55; SCG6; SCG6 (secretogranin VI); secretogranin VI; similar to XLalphas protein; XL alpha s; Xlas
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83183,489,648 - 183,554,570 (+)NCBIGRCr8
mRatBN7.23163,071,003 - 163,136,350 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3163,071,417 - 163,136,350 (+)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl3163,071,417 - 163,127,262 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3166,870,185 - 166,935,111 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03175,366,829 - 175,431,728 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03173,111,029 - 173,175,955 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03172,374,957 - 172,434,988 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3172,385,672 - 172,434,613 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl3172,374,957 - 172,428,483 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03178,426,255 - 178,427,409 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.03178,439,178 - 178,490,287 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43165,213,399 - 165,214,551 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3162,244,932 - 162,311,413 (+)NCBICelera
Cytogenetic Map3q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acromegaly  (ISO)
ACTH-independent macronodular adrenal hyperplasia  (ISO)
ACTH-independent macronodular adrenal hyperplasia 1  (ISO)
Adrenal Gland Neoplasms  (ISO)
adrenocortical carcinoma  (ISO)
Albright's hereditary osteodystrophy  (ISO,ISS)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis type 8  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
brachydactyly  (ISO)
Breast Neoplasms  (ISO)
Cafe-au-Lait Spots  (ISO)
cholangiocarcinoma  (ISO)
Colorectal Neoplasms  (ISO)
Cushing Syndrome  (ISO)
disease of cellular proliferation  (ISO)
Duane retraction syndrome  (ISO)
endocrine system disease  (ISO)
Gallstones  (ISO)
gastric adenocarcinoma  (ISO)
genetic disease  (ISO)
growth hormone secreting pituitary adenoma  (ISO)
head and neck squamous cell carcinoma  (ISO)
hemorrhagic disease  (ISO)
hepatocellular carcinoma  (ISO)
hereditary spastic paraplegia 4  (ISO)
Heterotopic Ossification  (ISO)
hypertension  (ISO)
Hypoxia  (ISO)
Insulin Resistance  (ISO)
intellectual disability  (ISO)
lung adenocarcinoma  (ISO)
McCune Albright syndrome  (ISO)
melanoma  (ISO)
Metabolic Bone Diseases  (ISO)
neuroblastoma  (ISO)
obesity  (ISO)
Orthostatic Hypotension  (ISO)
pancreatic adenocarcinoma  (ISO)
pancreatic cancer  (ISO)
Parasitic Liver Diseases  (ISO)
pituitary adenoma 3  (ISO)
Pituitary Neoplasms  (ISO)
polycystic kidney disease  (IEP)
polycystic ovary syndrome  (ISO)
Precocious Puberty  (ISO)
primary hyperaldosteronism  (ISO)
progressive osseous heteroplasia  (ISO)
pseudohypoaldosteronism  (ISO)
pseudohypoparathyroidism  (ISO,ISS)
pseudohypoparathyroidism type IB  (ISO)
Pseudohypoparathyroidism Type IC  (ISO)
pseudopseudohypoparathyroidism  (ISO,ISS)
Respiration Disorders  (ISO)
schizophrenia  (ISS)
sex cord-gonadal stromal tumor  (ISO)
skin melanoma  (ISO)
Tachycardia  (ISO)
Uterine Cervical Neoplasms  (ISO)
withdrawal disorder  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (ISO)
(1->4)-beta-D-glucan  (ISO)
(R)-noradrenaline  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,5-dichlorophenol  (ISO)
3',5'-cyclic AMP  (ISO)
3,3'-diindolylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
5-(hydroxymethyl)cytosine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
alpha-pinene  (ISO)
alprenolol  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
bathocuproine disulfonic acid  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisoprolol  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
butanal  (ISO)
caffeine  (EXP)
calcium atom  (ISO)
calcium(0)  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carvedilol  (EXP,ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
chloroprene  (EXP)
chlorpyrifos  (ISO)
cholesterol  (ISO)
cicaprost  (ISO)
cisplatin  (ISO)
citronellal  (ISO)
clozapine  (EXP,ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (EXP)
Cuprizon  (ISO)
cyclosporin A  (ISO)
dexamethasone  (EXP)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
diclofenac  (ISO)
dioxygen  (EXP,ISO)
dobutamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethyl methanesulfonate  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
finasteride  (EXP)
flavonoids  (EXP)
fluoxetine  (EXP)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
genistein  (EXP,ISO)
guanosine 5'-[gamma-thio]triphosphate  (ISO)
haloperidol  (EXP)
hydrogen peroxide  (ISO)
ICI 118551  (ISO)
indometacin  (EXP)
isoprenaline  (EXP,ISO)
ivermectin  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
mercury dibromide  (ISO)
Mesaconitine  (EXP)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
methylparaben  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
morphine  (EXP)
N-ethyl-N-nitrosourea  (ISO)
nefazodone  (EXP)
nimesulide  (EXP)
Nor-9-carboxy-delta9-THC  (ISO)
oleanolic acid  (ISO)
ozone  (EXP,ISO)
panobinostat  (ISO)
paracetamol  (EXP)
paraquat  (EXP,ISO)
PCB138  (EXP)
pentobarbital  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenanthrene  (ISO)
phencyclidine  (ISO)
phenobarbital  (EXP)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP,ISO)
potassium chloride  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP,ISO)
propranolol  (EXP,ISO)
propylparaben  (ISO)
pyrrolidine dithiocarbamate  (ISO)
reserpine  (EXP)
resveratrol  (ISO)
sarin  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (EXP)
sodium arsenite  (ISO)
Soman  (EXP)
sulindac  (EXP)
sunitinib  (ISO)
terbutaline  (EXP)
tert-butyl hydroperoxide  (ISO)
thapsigargin  (EXP)
theophylline  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
tremolite asbestos  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triptonide  (ISO)
tunicamycin  (ISO)
U-73122  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
zinc sulfate  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating adrenergic receptor signaling pathway  (ISO,ISS)
adenylate cyclase-activating dopamine receptor signaling pathway  (IBA,IDA,IEA,ISO)
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IDA,IMP,ISO)
bone development  (ISO)
cartilage development  (IEA,ISO)
cellular response to catecholamine stimulus  (IDA)
cellular response to glucagon stimulus  (IEA,ISO)
cellular response to prostaglandin E stimulus  (IDA)
cognition  (ISO)
developmental growth  (ISO)
embryonic cranial skeleton morphogenesis  (IEA,ISO)
embryonic hindlimb morphogenesis  (IEA,ISO)
endochondral ossification  (IEA,ISO)
energy reserve metabolic process  (IEA,ISO)
G protein-coupled receptor signaling pathway  (IEA,IMP)
genomic imprinting  (IEA,ISO)
hair follicle placode formation  (ISO)
multicellular organism growth  (IEA,ISO)
negative regulation of blood pressure  (IMP)
negative regulation of multicellular organism growth  (ISO)
platelet aggregation  (ISO)
positive regulation of cell population proliferation  (IDA)
positive regulation of cold-induced thermogenesis  (IEA,ISO,ISS)
positive regulation of insulin secretion  (IEA,ISO)
positive regulation of osteoblast differentiation  (IEA,ISO)
positive regulation of osteoclast differentiation  (IEA,ISO)
positive regulation of protein phosphorylation  (IMP)
positive regulation of sodium ion transport  (IMP)
post-embryonic body morphogenesis  (IEA,ISO)
post-embryonic development  (ISO)
regulation of parathyroid hormone secretion  (IEA,ISO)
regulation of signal transduction  (ISO)
regulation of transcription by RNA polymerase II  (IMP)
response to parathyroid hormone  (IEA,ISO)
response to prostaglandin E  (ISO)
response to xenobiotic stimulus  (IEA,ISO)
sensory perception of chemical stimulus  (IBA)
skeletal system development  (ISO)
skin development  (IEA,ISO)
tissue homeostasis  (IEA,ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Association of GNAS1 gene variant with hypertension depending on smoking status. Abe M, etal., Hypertension. 2002 Sep;40(3):261-5.
2. Analysis of the GNAS1 gene in Albright's hereditary osteodystrophy. Ahrens W, etal., J Clin Endocrinol Metab. 2001 Oct;86(10):4630-4.
3. Functional characterization of heterotrimeric G-proteins in rat diaphragm muscle. Andrade-Lopes AL, etal., Respir Physiol Neurobiol. 2011 Feb 15;175(2):212-9. Epub 2010 Nov 23.
4. The heterotrimeric G protein subunits Galpha(q) and Gbeta(1) have lysophospholipase D activity. Aoyama C, etal., Biochem J. 2011 Dec 1;440(2):241-50. doi: 10.1042/BJ20110545.
5. Sex differences in corticotropin-releasing factor receptor signaling and trafficking: potential role in female vulnerability to stress-related psychopathology. Bangasser DA, etal., Mol Psychiatry. 2010 Sep;15(9):877, 896-904. Epub 2010 Jun 15.
6. GNAS locus and pseudohypoparathyroidism. Bastepe M and Juppner H, Horm Res. 2005;63(2):65-74. Epub 2005 Feb 9.
7. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
8. Physiology and pathophysiology of the vasopressin-regulated renal water reabsorption. Boone M and Deen PM, Pflugers Arch. 2008 Sep;456(6):1005-24. Epub 2008 Apr 23.
9. The melanocortin system in control of inflammation. Catania A, etal., ScientificWorldJournal. 2010 Sep 14;10:1840-53.
10. Alterations in hepatic glucagon receptor density and in Gsalpha and Gialpha2 protein content with diet-induced hepatic steatosis: effects of acute exercise. Charbonneau A, etal., Am J Physiol Endocrinol Metab. 2005 Jul;289(1):E8-14. Epub 2005 Feb 1.
11. G(s)alpha deficiency in adipose tissue leads to a lean phenotype with divergent effects on cold tolerance and diet-induced thermogenesis. Chen M, etal., Cell Metab. 2010 Apr 7;11(4):320-30. doi: 10.1016/j.cmet.2010.02.013.
12. Enhancement of AG1024-induced H9c2 cardiomyoblast cell apoptosis via the interaction of IGF2R with Galpha proteins and its downstream PKA and PLC-beta modulators by IGF-II. Chu CH, etal., Chin J Physiol. 2009 Feb 28;52(1):31-7.
13. Expression of G-protein alpha subunit genes in the vestibular periphery of Rattus norvegicus and their chromosomal mapping. Cioffi JA, etal., Acta Otolaryngol 2003 Dec;123(9):1027-34.
14. Neural expression of a novel alternatively spliced and polyadenylated Gs alpha transcript. Crawford JA, etal., J Biol Chem 1993 May 5;268(13):9879-85.
15. Molecular analysis of the GNAS1 gene for the correct diagnosis of Albright hereditary osteodystrophy and pseudohypoparathyroidism. De Sanctis L, etal., Pediatr Res. 2003 May;53(5):749-55. Epub 2003 Mar 5.
16. Type VIII adenylyl cyclase in rat beta cells: coincidence signal detector/generator for glucose and GLP-1. Delmeire D, etal., Diabetologia. 2003 Oct;46(10):1383-93. Epub 2003 Sep 17.
17. Beta-adrenergic stimulation and myocardial function in the failing heart. El-Armouche A and Eschenhagen T, Heart Fail Rev. 2009 Dec;14(4):225-41.
18. Neuroendocrine secretory protein 55: a novel marker for the constitutive secretory pathway. Fischer-Colbrie R, etal., Ann N Y Acad Sci 2002 Oct;971:317-22.
19. Cushing's syndrome secondary to adrenocorticotropin-independent macronodular adrenocortical hyperplasia due to activating mutations of GNAS1 gene. Fragoso MC, etal., J Clin Endocrinol Metab. 2003 May;88(5):2147-51.
20. GNAS defects identified by stimulatory G protein alpha-subunit signalling studies in platelets. Freson K, etal., J Clin Endocrinol Metab. 2008 Dec;93(12):4851-9. doi: 10.1210/jc.2008-0883. Epub 2008 Sep 23.
21. The GNAS1 T393C polymorphism is associated with disease progression and survival in chronic lymphocytic leukemia. Frey UH, etal., Clin Cancer Res. 2006 Oct 1;12(19):5686-92.
22. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
23. The CC genotype of the GNAS T393C polymorphism is associated with obesity and insulin resistance in women with polycystic ovary syndrome. Hahn S, etal., Eur J Endocrinol. 2006 Nov;155(5):763-70.
24. G-protein-coupled receptor signaling components localize in both sarcolemmal and intracellular caveolin-3-associated microdomains in adult cardiac myocytes. Head BP, etal., J Biol Chem. 2005 Sep 2;280(35):31036-44. Epub 2005 Jun 16.
25. The molecular mechanisms underlying the regulation of the biological activity of corticotropin-releasing hormone receptors: implications for physiology and pathophysiology. Hillhouse EW and Grammatopoulos DK, Endocr Rev. 2006 May;27(3):260-86. Epub 2006 Feb 16.
26. Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Specific activation of Gsalpha by an NDPK B.Gbetagamma complex in H10 cells. Hippe HJ, etal., J Biol Chem. 2003 Feb 28;278(9):7227-33. Epub 2002 Dec 16.
27. Science review: Vasopressin and the cardiovascular system part 1--receptor physiology. Holmes CL, etal., Crit Care. 2003 Dec;7(6):427-34. Epub 2003 Jun 26.
28. Live cell imaging of Gs and the beta2-adrenergic receptor demonstrates that both alphas and beta1gamma7 internalize upon stimulation and exhibit similar trafficking patterns that differ from that of the beta2-adrenergic receptor. Hynes TR, etal., J Biol Chem. 2004 Oct 15;279(42):44101-12. Epub 2004 Aug 5.
29. Molecular cloning and sequence determination of cDNAs for alpha subunits of the guanine nucleotide-binding proteins Gs, Gi, and Go from rat brain. Itoh H, etal., Proc Natl Acad Sci U S A 1986 Jun;83(11):3776-80.
30. NESP55, a novel chromogranin-like peptide, is expressed in endocrine tumours of the pancreas and adrenal medulla but not in ileal carcinoids. Jakobsen AM, etal., Br J Cancer. 2003 Jun 2;88(11):1746-54.
31. Angiotensin II regulates V2 receptor and pAQP2 during ureteral obstruction. Jensen AM, etal., Am J Physiol Renal Physiol. 2009 Jan;296(1):F127-34. Epub 2008 Oct 29.
32. Assembly of a beta2-adrenergic receptor--GluR1 signalling complex for localized cAMP signalling. Joiner ML, etal., EMBO J. 2010 Jan 20;29(2):482-95. Epub 2009 Nov 26.
33. Molecular cloning of five GTP-binding protein cDNA species from rat olfactory neuroepithelium. Jones DT and Reed RR, J Biol Chem 1987 Oct 15;262(29):14241-9.
34. XL alpha s is a new type of G protein. Kehlenbach RH, etal., Nature 1994 Dec 22-29;372(6508):804-9.
35. Indomethacin enhances shuttling of aquaporin-2 despite decreased abundance in rat kidney. Kim SW, etal., J Am Soc Nephrol. 2004 Dec;15(12):2998-3005.
36. Two overlapping reading frames in a single exon encode interacting proteins--a novel way of gene usage. Klemke M, etal., EMBO J. 2001 Jul 16;20(14):3849-60.
37. GTPase inhibiting mutations activate the alpha chain of Gs and stimulate adenylyl cyclase in human pituitary tumours. Landis CA, etal., Nature. 1989 Aug 31;340(6236):692-6.
38. Identification and characterization of GIV, a novel Galpha i/s-interacting protein found on COPI, endoplasmic reticulum-Golgi transport vesicles. Le-Niculescu H, etal., J Biol Chem. 2005 Jun 10;280(23):22012-20. Epub 2005 Mar 4.
39. Peripheral projections of NESP55 containing neurons in the rat sympathetic ganglia. Li Y and Dahlstrom A, Auton Neurosci. 2008 Aug 18;141(1-2):1-9. doi: 10.1016/j.autneu.2008.03.008. Epub 2008 Jun 6.
40. Distinct patterns of abnormal GNAS imprinting in familial and sporadic pseudohypoparathyroidism type IB. Liu J, etal., Hum Mol Genet. 2005 Jan 1;14(1):95-102. Epub 2004 Nov 10.
41. Transgenic overexpression of the extra-large Gsalpha variant XLalphas enhances Gsalpha-mediated responses in the mouse renal proximal tubule in vivo. Liu Z, etal., Endocrinology. 2011 Apr;152(4):1222-33. Epub 2011 Feb 8.
42. Modulation of rat cardiac sodium channel by the stimulatory G protein alpha subunit. Lu T, etal., J Physiol. 1999 Jul 15;518 ( Pt 2):371-84.
43. Mutational analysis of GNAS1 in patients with pseudohypoparathyroidism: identification of two novel mutations. Mantovani G, etal., J Clin Endocrinol Metab. 2000 Nov;85(11):4243-8.
44. Parental origin of Gsalpha mutations in the McCune-Albright syndrome and in isolated endocrine tumors. Mantovani G, etal., J Clin Endocrinol Metab. 2004 Jun;89(6):3007-9.
45. TGR5 contributes to hepatic cystogenesis in rodents with polycystic liver diseases through cyclic adenosine monophosphate/Gαs signaling. Masyuk TV, etal., Hepatology. 2017 Oct;66(4):1197-1218. doi: 10.1002/hep.29284. Epub 2017 Aug 26.
46. Glucagon-mediated internalization of serine-phosphorylated glucagon receptor and Gsalpha in rat liver. Merlen C, etal., FEBS Lett. 2006 Oct 16;580(24):5697-704. Epub 2006 Sep 20.
47. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
48. G protein betagamma subunits interact with alphabeta- and gamma-tubulin and play a role in microtubule assembly in PC12 cells. Montoya V, etal., Cell Motil Cytoskeleton. 2007 Dec;64(12):936-50.
49. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
50. Regionally selective alterations in G protein subunit levels in the Alzheimer's disease brain. O'Neill C, etal., Brain Res. 1994 Feb 14;636(2):193-201.
51. Interaction of alpha1-syntrophin with multiple isoforms of heterotrimeric G protein alpha subunits. Okumura A, etal., FEBS J. 2008 Jan;275(1):22-33. Epub 2007 Nov 23.
52. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
53. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
54. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
55. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
56. Unexpected mosaicism of R201H-GNAS1 mutant-bearing cells in the testes underlie macro-orchidism without sexual precocity in McCune-Albright syndrome. Rey RA, etal., Hum Mol Genet. 2006 Dec 15;15(24):3538-43. Epub 2006 Nov 13.
57. GOA pipeline RGD automated data pipeline
58. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
59. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
60. A new deletion ablating NESP55 causes loss of maternal imprint of A/B GNAS and autosomal dominant pseudohypoparathyroidism type Ib. Richard N, etal., J Clin Endocrinol Metab. 2012 May;97(5):E863-7. doi: 10.1210/jc.2011-2804. Epub 2012 Feb 29.
61. Conditional overexpression of the wild-type Gs alpha as the gsp oncogene initiates chronic extracellularly regulated kinase 1/2 activation and hormone hypersecretion in pituitary cell lines. Romano D, etal., Endocrinology. 2007 Jun;148(6):2973-83. Epub 2007 Mar 15.
62. Physiological roles for G protein-regulated adenylyl cyclase isoforms: insights from knockout and overexpression studies. Sadana R and Dessauer CW, Neurosignals. 2009;17(1):5-22. Epub 2008 Oct 24.
63. Functional reconstitution of G-protein-coupled receptor-mediated adenylyl cyclase activation by a baculoviral co-display system. Sakihama T, etal., J Biotechnol. 2008 May 20;135(1):28-33. doi: 10.1016/j.jbiotec.2008.02.022. Epub 2008 Mar 7.
64. Treatment with atorvastatin partially protects the rat heart from harmful catecholamine effects. Schmechel A, etal., Cardiovasc Res. 2009 Apr 1;82(1):100-6. Epub 2009 Jan 9.
65. GNAS1 T393C polymorphism is associated with clinical course in patients with intrahepatic cholangiocarcinoma. Schmitz KJ, etal., Neoplasia. 2007 Feb;9(2):159-65.
66. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
67. Differential expression of novel Gs alpha signal transduction protein cDNA species. Swaroop A, etal., Nucleic Acids Res 1991 Sep 11;19(17):4725-9.
68. Polymorphisms of genes encoding components of the sympathetic nervous system but not the renin-angiotensin system as risk factors for orthostatic hypotension. Tabara Y, etal., J Hypertens. 2002 Apr;20(4):651-6.
69. Rosiglitazone restores renal D1A receptor-Gs protein coupling by reducing receptor hyperphosphorylation in obese rats. Trivedi M and Lokhandwala MF, Am J Physiol Renal Physiol. 2005 Aug;289(2):F298-304. Epub 2005 Mar 29.
70. Ultra-low dose naloxone restores the antinociceptive effect of morphine in pertussis toxin-treated rats by reversing the coupling of mu-opioid receptors from Gs-protein to coupling to Gi-protein. Tsai RY, etal., Neuroscience. 2009 Dec 1;164(2):435-43. Epub 2009 Aug 12.
71. A proline-rich region and nearby cysteine residues target XLalphas to the Golgi complex region. Ugur O and Jones TL, Mol Biol Cell. 2000 Apr;11(4):1421-32.
72. Partial rescue of functional interactions of a nonpalmitoylated mutant of the G-protein G alpha s by fusion to the beta-adrenergic receptor. Ugur O, etal., Biochemistry 2003 Mar 11;42(9):2607-15.
73. Functional selectivity of central Galpha-subunit proteins in mediating the cardiovascular and renal excretory responses evoked by central alpha(2) -adrenoceptor activation in vivo. Wainford RD and Kapusta DR, Br J Pharmacol. 2011 Sep 6. doi: 10.1111/j.1476-5381.2011.01662.x.
74. Gbetagamma that interacts with adenylyl cyclase in opioid tolerance originates from a Gs protein. Wang HY and Burns LH, J Neurobiol. 2006 Oct;66(12):1302-10.
75. Antagonist minigenes identify genes regulated by parathyroid hormone through G protein-selective and G protein co-regulated mechanisms in osteoblastic cells. Wang J, etal., Cell Signal. 2011 Feb;23(2):380-8. Epub 2010 Oct 19.
76. Mutations of the Gs alpha-subunit gene in Albright hereditary osteodystrophy detected by denaturing gradient gel electrophoresis. Weinstein LS, etal., Proc Natl Acad Sci U S A. 1990 Nov;87(21):8287-90.
77. Neuroendocrine secretory protein 55 (NESP55): alternative splicing onto transcripts of the GNAS gene and posttranslational processing of a maternally expressed protein. Weiss U, etal., Neuroendocrinology 2000 Mar;71(3):177-86.
78. VIP induces the translocation and degradation of the alpha subunit of Gs protein in rat pituitary GH4C1 cells. Yajima Y, etal., J Biochem. 1998 Jun;123(6):1024-30.
79. Identification of two novel deletion mutations within the Gs alpha gene (GNAS1) in Albright hereditary osteodystrophy. Yu D, etal., J Clin Endocrinol Metab. 1999 Sep;84(9):3254-9.
80. Chronic treatment with escitalopram but not R-citalopram translocates Galpha(s) from lipid raft domains and potentiates adenylyl cyclase: a 5-hydroxytryptamine transporter-independent action of this antidepressant compound. Zhang L and Rasenick MM, J Pharmacol Exp Ther. 2010 Mar;332(3):977-84. Epub 2009 Dec 8.
Additional References at PubMed
PMID:799727   PMID:2499043   PMID:2826231   PMID:3092218   PMID:7500342   PMID:8347607   PMID:8679006   PMID:8889548   PMID:9016340   PMID:9322912   PMID:9603210   PMID:10675785  
PMID:10712433   PMID:10931823   PMID:10931851   PMID:11438605   PMID:12221292   PMID:12391161   PMID:12719376   PMID:14767559   PMID:15057822   PMID:15148396   PMID:15381255   PMID:15489334  
PMID:15496483   PMID:15546818   PMID:15579796   PMID:15797856   PMID:15811946   PMID:15972823   PMID:16379030   PMID:16478979   PMID:16631471   PMID:17110384   PMID:17194762   PMID:18067150  
PMID:19199708   PMID:19237344   PMID:19946888   PMID:19966281   PMID:20427744   PMID:20458337   PMID:20862257   PMID:21584660   PMID:21606326   PMID:21890629   PMID:22573829   PMID:22871113  
PMID:23376485   PMID:23533145   PMID:23839232   PMID:25691569   PMID:27432886   PMID:28260721   PMID:29476059   PMID:30053369   PMID:31374326   PMID:33450132  


Genomics

Comparative Map Data
Gnas
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83183,489,648 - 183,554,570 (+)NCBIGRCr8
mRatBN7.23163,071,003 - 163,136,350 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3163,071,417 - 163,136,350 (+)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl3163,071,417 - 163,127,262 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3166,870,185 - 166,935,111 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03175,366,829 - 175,431,728 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03173,111,029 - 173,175,955 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03172,374,957 - 172,434,988 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3172,385,672 - 172,434,613 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl3172,374,957 - 172,428,483 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03178,426,255 - 178,427,409 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.03178,439,178 - 178,490,287 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43165,213,399 - 165,214,551 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3162,244,932 - 162,311,413 (+)NCBICelera
Cytogenetic Map3q43NCBI
GNAS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382058,839,748 - 58,911,192 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2058,839,718 - 58,911,192 (+)EnsemblGRCh38hg38GRCh38
GRCh372057,414,803 - 57,486,247 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362056,848,190 - 56,919,645 (+)NCBINCBI36Build 36hg18NCBI36
Build 342056,900,129 - 56,919,640NCBI
Celera2054,155,257 - 54,226,691 (+)NCBICelera
Cytogenetic Map20q13.32NCBI
HuRef2054,201,757 - 54,273,094 (+)NCBIHuRef
CHM1_12057,316,685 - 57,387,667 (+)NCBICHM1_1
T2T-CHM13v2.02060,622,888 - 60,694,319 (+)NCBIT2T-CHM13v2.0
Gnas
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392174,126,113 - 174,188,537 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2174,126,113 - 174,188,537 (+)EnsemblGRCm39 Ensembl
GRCm382174,284,320 - 174,346,744 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2174,284,320 - 174,346,744 (+)EnsemblGRCm38mm10GRCm38
MGSCv372174,109,821 - 174,172,245 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362173,927,260 - 173,989,683 (+)NCBIMGSCv36mm8
Celera2180,249,319 - 180,306,988 (+)NCBICelera
Cytogenetic Map2H4NCBI
cM Map297.89NCBI
GNAS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22164,603,402 - 64,674,018 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12064,596,523 - 64,667,139 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02055,190,607 - 55,262,245 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12056,460,906 - 56,620,313 (+)NCBIpanpan1.1PanPan1.1panPan2
GNAS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12443,643,409 - 43,658,641 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2443,643,405 - 43,658,657 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2442,885,440 - 42,905,085 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02444,469,667 - 44,524,884 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2444,457,089 - 44,540,809 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12443,609,062 - 43,628,699 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02443,727,472 - 43,747,093 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02444,387,669 - 44,407,318 (+)NCBIUU_Cfam_GSD_1.0
LOC101971027
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640181,895,749 - 181,952,790 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365301,353,432 - 1,407,437 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GNAS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1758,998,981 - 59,053,021 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11758,985,580 - 59,053,022 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21766,303,970 - 66,356,738 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.21766,408,660 - 66,423,431 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap17qNCBI
LOC103243509
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.125,233,893 - 5,303,433 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl25,233,874 - 5,249,192 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605053,288,032 - 53,358,025 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gnas
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474125,183,329 - 25,196,880 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474125,138,678 - 25,197,194 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gnas
158 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:163
Count of miRNA genes:117
Interacting mature miRNAs:137
Transcripts:ENSRNOT00000035916, ENSRNOT00000071215
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3145925360166177555Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3145925360166177555Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3145925360166177555Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3145925360166177555Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3145925360166177555Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3145925360166177555Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
1300161Rf10Renal function QTL 103.57renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)3161192952169034231Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3145956084169034231Rat
2317883Alcrsp26Alcohol response QTL 261.80.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)3145526770169034231Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3149040888168026850Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3145925360166177555Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat

Markers in Region
D3Wox4  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera3162,307,581 - 162,307,759UniSTS
Cytogenetic Map3q42UniSTS
RH11717  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23163,135,975 - 163,136,136 (+)MAPPERmRatBN7.2
Rnor_6.03172,434,614 - 172,434,774NCBIRnor6.0
Rnor_5.03178,489,913 - 178,490,073UniSTSRnor5.0
Celera3162,311,039 - 162,311,199UniSTS
Cytogenetic Map3q42UniSTS
RH132134  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23163,126,950 - 163,127,162 (+)MAPPERmRatBN7.2
Rnor_6.03172,428,172 - 172,428,383NCBIRnor6.0
Rnor_5.03178,481,664 - 178,481,875UniSTSRnor5.0
Celera3162,301,092 - 162,301,303UniSTS
Cytogenetic Map3q42UniSTS
BF395949  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23163,083,790 - 163,083,972 (+)MAPPERmRatBN7.2
Rnor_6.03172,384,449 - 172,384,630NCBIRnor6.0
Rnor_5.03178,437,955 - 178,438,136UniSTSRnor5.0
Celera3162,260,412 - 162,260,593UniSTS
RH 3.4 Map31498.5UniSTS
Cytogenetic Map3q42UniSTS
BF389724  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23163,090,308 - 163,090,541 (+)MAPPERmRatBN7.2
Rnor_6.03172,390,966 - 172,391,198NCBIRnor6.0
Rnor_5.03178,444,411 - 178,444,643UniSTSRnor5.0
Celera3162,267,544 - 162,267,776UniSTS
RH 3.4 Map31499.49UniSTS
Cytogenetic Map3q42UniSTS
BF398043  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera3162,307,324 - 162,307,509UniSTS
RH 3.4 Map31496.8UniSTS
Cytogenetic Map3q42UniSTS
RH94424  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23163,136,060 - 163,136,220 (+)MAPPERmRatBN7.2
Rnor_6.03172,434,699 - 172,434,858NCBIRnor6.0
Rnor_5.03178,489,998 - 178,490,157UniSTSRnor5.0
Celera3162,311,124 - 162,311,283UniSTS
Cytogenetic Map3q42UniSTS
RH139191  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23163,075,746 - 163,075,908 (+)MAPPERmRatBN7.2
Rnor_6.03172,379,285 - 172,379,446NCBIRnor6.0
Rnor_5.03178,430,583 - 178,430,744UniSTSRnor5.0
RGSC_v3.43165,217,727 - 165,217,888UniSTSRGSC3.4
Celera3162,249,260 - 162,249,421UniSTS
RH 3.4 Map31496.8UniSTS
Cytogenetic Map3q42UniSTS
AI230657  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23163,122,699 - 163,122,911 (+)MAPPERmRatBN7.2
Rnor_6.03172,423,921 - 172,424,132NCBIRnor6.0
Rnor_5.03178,477,413 - 178,477,624UniSTSRnor5.0
Celera3162,296,842 - 162,297,053UniSTS
RH 3.4 Map31496.9UniSTS
Cytogenetic Map3q42UniSTS
Gnas  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera3162,308,221 - 162,309,788UniSTS
Cytogenetic Map3q42UniSTS
UniSTS:496676  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23163,135,341 - 163,136,087 (+)MAPPERmRatBN7.2
Rnor_6.03172,433,980 - 172,434,725NCBIRnor6.0
Rnor_5.03178,489,279 - 178,490,024UniSTSRnor5.0
Celera3162,310,405 - 162,311,150UniSTS
Cytogenetic Map3q42UniSTS
Gnas  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera3162,310,126 - 162,310,977UniSTS
Cytogenetic Map3q42UniSTS
PMC22380P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23163,086,945 - 163,087,293 (+)MAPPERmRatBN7.2
Rnor_6.03172,387,604 - 172,387,950NCBIRnor6.0
Rnor_5.03178,441,110 - 178,441,395UniSTSRnor5.0
Cytogenetic Map3q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
18 22 98 226 182 180 118 50 118 12 436 194 186 90 120 62

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001024823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001159653 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001159656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001359867 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_019132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_021845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283123 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010064564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010064565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAHX01026999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF093569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF105254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF107844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF107845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF184151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC158589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC168156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF394587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB770483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ120475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ120476 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214546 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219804 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233896 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L10326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M12673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M17525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U51565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X84047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000035916   ⟹   ENSRNOP00000033065
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3163,071,417 - 163,127,262 (+)Ensembl
Rnor_6.0 Ensembl3172,374,957 - 172,428,483 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000071215   ⟹   ENSRNOP00000066164
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl3172,420,591 - 172,434,613 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000090989   ⟹   ENSRNOP00000069800
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3163,085,014 - 163,131,858 (+)Ensembl
Rnor_6.0 Ensembl3172,385,672 - 172,433,441 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095590   ⟹   ENSRNOP00000088089
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3163,085,014 - 163,136,316 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099707   ⟹   ENSRNOP00000091559
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3163,071,417 - 163,136,316 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000111199   ⟹   ENSRNOP00000080642
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3163,119,163 - 163,136,316 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112766   ⟹   ENSRNOP00000094944
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3163,085,014 - 163,135,975 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000115047   ⟹   ENSRNOP00000086723
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3163,133,950 - 163,136,350 (+)Ensembl
RefSeq Acc Id: NM_001024823   ⟹   NP_001019994
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83183,503,243 - 183,554,570 (+)NCBI
mRatBN7.23163,085,014 - 163,136,350 (+)NCBI
Rnor_6.03172,385,672 - 172,434,988 (+)NCBI
Rnor_5.03178,439,178 - 178,490,287 (+)NCBI
Celera3162,261,635 - 162,311,413 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001159653   ⟹   NP_001153125
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83183,489,648 - 183,554,570 (+)NCBI
mRatBN7.23163,071,417 - 163,136,350 (+)NCBI
Rnor_6.03172,374,957 - 172,434,988 (+)NCBI
Rnor_5.03178,426,255 - 178,427,409 (+)NCBI
Rnor_5.03178,439,178 - 178,490,287 (+)NCBI
RGSC_v3.43165,213,399 - 165,214,551 (+)RGD
Celera3162,244,932 - 162,311,413 (+)RGD
Sequence:
RefSeq Acc Id: NM_001159656   ⟹   NP_001153128
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83183,489,648 - 183,545,487 (+)NCBI
mRatBN7.23163,071,417 - 163,127,264 (+)NCBI
Rnor_6.03172,374,957 - 172,428,485 (+)NCBI
Rnor_5.03178,426,255 - 178,427,409 (+)NCBI
Rnor_5.03178,439,178 - 178,490,287 (+)NCBI
RGSC_v3.43165,213,399 - 165,214,551 (+)RGD
Celera3162,244,932 - 162,301,405 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001359867   ⟹   NP_001346796
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83183,537,339 - 183,554,570 (+)NCBI
mRatBN7.23163,119,113 - 163,136,350 (+)NCBI
RefSeq Acc Id: NM_019132   ⟹   NP_062005
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83183,537,339 - 183,554,570 (+)NCBI
mRatBN7.23163,119,113 - 163,136,350 (+)NCBI
Rnor_6.03172,420,409 - 172,434,984 (+)NCBI
Rnor_5.03178,439,178 - 178,490,287 (+)NCBI
Celera3162,297,458 - 162,311,409 (+)NCBI
Sequence:
RefSeq Acc Id: NM_021845   ⟹   NP_068617
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83183,503,243 - 183,554,570 (+)NCBI
mRatBN7.23163,085,014 - 163,136,350 (+)NCBI
Rnor_6.03172,385,672 - 172,434,988 (+)NCBI
Rnor_5.03178,439,178 - 178,490,287 (+)NCBI
Celera3162,261,635 - 162,311,413 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039104294   ⟹   XP_038960222
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83183,502,664 - 183,554,570 (+)NCBI
mRatBN7.23163,085,002 - 163,136,350 (+)NCBI
RefSeq Acc Id: XM_039104295   ⟹   XP_038960223
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83183,502,664 - 183,554,570 (+)NCBI
mRatBN7.23163,085,002 - 163,136,350 (+)NCBI
RefSeq Acc Id: XM_039104300   ⟹   XP_038960228
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83183,502,664 - 183,506,893 (+)NCBI
mRatBN7.23163,083,030 - 163,091,563 (+)NCBI
RefSeq Acc Id: XM_039104304   ⟹   XP_038960232
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83183,537,149 - 183,554,570 (+)NCBI
mRatBN7.23163,119,119 - 163,136,350 (+)NCBI
RefSeq Acc Id: XM_039104306   ⟹   XP_038960234
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83183,490,668 - 183,554,570 (+)NCBI
mRatBN7.23163,072,442 - 163,136,350 (+)NCBI
RefSeq Acc Id: XM_039104307   ⟹   XP_038960235
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83183,490,668 - 183,554,570 (+)NCBI
mRatBN7.23163,072,442 - 163,136,350 (+)NCBI
RefSeq Acc Id: XM_063283121   ⟹   XP_063139191
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83183,502,664 - 183,554,570 (+)NCBI
RefSeq Acc Id: XM_063283122   ⟹   XP_063139192
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83183,537,124 - 183,554,570 (+)NCBI
RefSeq Acc Id: XM_063283123   ⟹   XP_063139193
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83183,490,668 - 183,554,570 (+)NCBI
RefSeq Acc Id: XM_063283124   ⟹   XP_063139194
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83183,489,988 - 183,527,444 (+)NCBI
RefSeq Acc Id: XR_010064564
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83183,489,988 - 183,527,444 (+)NCBI
RefSeq Acc Id: XR_010064565
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83183,489,988 - 183,527,444 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001019994 (Get FASTA)   NCBI Sequence Viewer  
  NP_001153125 (Get FASTA)   NCBI Sequence Viewer  
  NP_001153128 (Get FASTA)   NCBI Sequence Viewer  
  NP_001346796 (Get FASTA)   NCBI Sequence Viewer  
  NP_062005 (Get FASTA)   NCBI Sequence Viewer  
  NP_068617 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960222 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960223 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960228 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960232 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960234 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960235 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139191 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139192 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139193 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139194 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40827 (Get FASTA)   NCBI Sequence Viewer  
  AAA41261 (Get FASTA)   NCBI Sequence Viewer  
  AAA41664 (Get FASTA)   NCBI Sequence Viewer  
  AAD03032 (Get FASTA)   NCBI Sequence Viewer  
  AAD03033 (Get FASTA)   NCBI Sequence Viewer  
  AAD11801 (Get FASTA)   NCBI Sequence Viewer  
  AAD11802 (Get FASTA)   NCBI Sequence Viewer  
  AAD11803 (Get FASTA)   NCBI Sequence Viewer  
  AAF37806 (Get FASTA)   NCBI Sequence Viewer  
  AAF63227 (Get FASTA)   NCBI Sequence Viewer  
  AAH61967 (Get FASTA)   NCBI Sequence Viewer  
  AAI58590 (Get FASTA)   NCBI Sequence Viewer  
  AAI68156 (Get FASTA)   NCBI Sequence Viewer  
  AAZ23814 (Get FASTA)   NCBI Sequence Viewer  
  AAZ23815 (Get FASTA)   NCBI Sequence Viewer  
  CAC39211 (Get FASTA)   NCBI Sequence Viewer  
  CAC39212 (Get FASTA)   NCBI Sequence Viewer  
  EDL85091 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000033065.3
  ENSRNOP00000069800.2
  ENSRNOP00000080642.1
  ENSRNOP00000086723.1
  ENSRNOP00000088089.1
  ENSRNOP00000091559.1
  ENSRNOP00000094944.1
  ENSRNOP00055001345
  ENSRNOP00055001745
  ENSRNOP00060000890
  ENSRNOP00065016847
GenBank Protein P63095 (Get FASTA)   NCBI Sequence Viewer  
  Q63803 (Get FASTA)   NCBI Sequence Viewer  
  Q792G6 (Get FASTA)   NCBI Sequence Viewer  
  Q9Z213 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_068617   ⟸   NM_021845
- Peptide Label: isoform XLas
- UniProtKB: Q63803 (UniProtKB/Swiss-Prot),   A0A8I6A4D8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001019994   ⟸   NM_001024823
- Peptide Label: isoform Alex
- UniProtKB: B4F771 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_062005   ⟸   NM_019132
- Peptide Label: isoform GNASL
- UniProtKB: Q45QM7 (UniProtKB/Swiss-Prot),   Q05087 (UniProtKB/Swiss-Prot),   Q9Z1R8 (UniProtKB/Swiss-Prot),   P63095 (UniProtKB/Swiss-Prot),   B0BMW4 (UniProtKB/TrEMBL),   B4F771 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001153125   ⟸   NM_001159653
- Peptide Label: isoform SCG6 precursor
- UniProtKB: Q792G6 (UniProtKB/Swiss-Prot),   G3V916 (UniProtKB/TrEMBL),   A6KL23 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001153128   ⟸   NM_001159656
- Peptide Label: isoform SCG6 precursor
- UniProtKB: Q792G6 (UniProtKB/Swiss-Prot),   G3V916 (UniProtKB/TrEMBL),   A6KL23 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000033065   ⟸   ENSRNOT00000035916
Ensembl Acc Id: ENSRNOP00000069800   ⟸   ENSRNOT00000090989
Ensembl Acc Id: ENSRNOP00000066164   ⟸   ENSRNOT00000071215
RefSeq Acc Id: XP_038960234   ⟸   XM_039104306
- Peptide Label: isoform X8
- UniProtKB: B4F771 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960235   ⟸   XM_039104307
- Peptide Label: isoform X9
- UniProtKB: B4F771 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960228   ⟸   XM_039104300
- Peptide Label: isoform X4
- UniProtKB: A0A0G2JWA1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960222   ⟸   XM_039104294
- Peptide Label: isoform X2
- UniProtKB: Q63803 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038960223   ⟸   XM_039104295
- Peptide Label: isoform X3
- UniProtKB: Q63803 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001346796   ⟸   NM_001359867
- Peptide Label: isoform b
- UniProtKB: B4F771 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960232   ⟸   XM_039104304
- Peptide Label: isoform X6
- UniProtKB: B4F771 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000094944   ⟸   ENSRNOT00000112766
Ensembl Acc Id: ENSRNOP00000088089   ⟸   ENSRNOT00000095590
Ensembl Acc Id: ENSRNOP00000080642   ⟸   ENSRNOT00000111199
Ensembl Acc Id: ENSRNOP00000091559   ⟸   ENSRNOT00000099707
Ensembl Acc Id: ENSRNOP00000086723   ⟸   ENSRNOT00000115047
RefSeq Acc Id: XP_063139194   ⟸   XM_063283124
- Peptide Label: isoform X10
- UniProtKB: Q792G6 (UniProtKB/Swiss-Prot),   A6KL23 (UniProtKB/TrEMBL),   G3V916 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139193   ⟸   XM_063283123
- Peptide Label: isoform X7
- UniProtKB: B4F771 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139191   ⟸   XM_063283121
- Peptide Label: isoform X1
- UniProtKB: Q63803 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063139192   ⟸   XM_063283122
- Peptide Label: isoform X5
- UniProtKB: B4F771 (UniProtKB/TrEMBL)
Protein Domains
G-alpha

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63803-F1-model_v2 AlphaFold Q63803 1-1144 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692719
Promoter ID:EPDNEW_R3243
Type:single initiation site
Name:Gnas_1
Description:GNAS complex locus
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03172,374,943 - 172,375,003EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2716 AgrOrtholog
BioCyc Gene G2FUF-46472 BioCyc
Ensembl Genes ENSRNOG00000025889 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000047374 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055001007 UniProtKB/Swiss-Prot
  ENSRNOG00055001386 UniProtKB/Swiss-Prot
  ENSRNOG00060001165 UniProtKB/Swiss-Prot
  ENSRNOG00065013234 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000035916.6 UniProtKB/TrEMBL
  ENSRNOT00000090989.2 UniProtKB/TrEMBL
  ENSRNOT00000095590.1 UniProtKB/TrEMBL
  ENSRNOT00000099707.1 UniProtKB/TrEMBL
  ENSRNOT00000111199.1 UniProtKB/Swiss-Prot
  ENSRNOT00000112766.1 UniProtKB/TrEMBL
  ENSRNOT00000115047.1 UniProtKB/TrEMBL
  ENSRNOT00055001712 UniProtKB/Swiss-Prot
  ENSRNOT00055002260 UniProtKB/Swiss-Prot
  ENSRNOT00060001672 UniProtKB/Swiss-Prot
  ENSRNOT00065021748 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.400.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9099119 IMAGE-MGC_LOAD
InterPro Gprotein_alpha_S UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gprotein_alpha_su UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GproteinA_insert UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NESP55 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24896 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:187374 IMAGE-MGC_LOAD
NCBI Gene 24896 ENTREZGENE
PANTHER GUANINE NUCLEOTIDE-BINDING PROTEIN G(S) SUBUNIT ALPHA ISOFORMS XLAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GUANINE NUCLEOTIDE-BINDING PROTEIN G(S) SUBUNIT ALPHA XL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10218 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam G-alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NESP55 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB GNAS RGD
PhenoGen Gnas PhenoGen
PRINTS GPROTEINA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPROTEINAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_ALPHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000025889 RatGTEx
  ENSRNOG00000047374 RatGTEx
  ENSRNOG00055001007 RatGTEx
  ENSRNOG00055001386 RatGTEx
  ENSRNOG00060001165 RatGTEx
  ENSRNOG00065013234 RatGTEx
SMART G_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47895 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JWA1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A4D8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AGC4_RAT UniProtKB/TrEMBL
  A0A8I6AN29_RAT UniProtKB/TrEMBL
  A0A8I6GEC0_RAT UniProtKB/TrEMBL
  A6KL23 ENTREZGENE, UniProtKB/TrEMBL
  A6KL27_RAT UniProtKB/TrEMBL
  ALEX_RAT UniProtKB/Swiss-Prot
  B0BMW4 ENTREZGENE, UniProtKB/TrEMBL
  B4F771 ENTREZGENE, UniProtKB/TrEMBL
  G3V916 ENTREZGENE, UniProtKB/TrEMBL
  GNAS1_RAT UniProtKB/Swiss-Prot
  GNAS2_RAT UniProtKB/Swiss-Prot
  GNAS3_RAT UniProtKB/Swiss-Prot
  P63095 ENTREZGENE
  Q05087 ENTREZGENE
  Q45QM7 ENTREZGENE
  Q63803 ENTREZGENE
  Q792G6 ENTREZGENE
  Q792H3_RAT UniProtKB/TrEMBL
  Q9Z1R8 ENTREZGENE
  Q9Z213 ENTREZGENE
UniProt Secondary P04894 UniProtKB/Swiss-Prot
  P08755 UniProtKB/Swiss-Prot
  Q05087 UniProtKB/Swiss-Prot
  Q45QM7 UniProtKB/Swiss-Prot
  Q924W1 UniProtKB/Swiss-Prot
  Q9Z1R8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-11-15 Gnas  GNAS complex locus  LOC100361691  GNAS complex locus XLas-like  Data merged from RGD:2319682 737654 APPROVED
2010-05-05 LOC100361691  GNAS complex locus XLas-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2009-06-15 Gnas  GNAS complex locus  LOC690994  similar to XLalphas protein  Data merged from RGD:1589791 737654 PROVISIONAL
2009-01-12 Gnas  GNAS complex locus  Gnas  GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Gnas  GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus  Gnas  GNAS complex locus  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-01-18 Gnas  GNAS complex locus  Xlas  XLas protein  Data merged from RGD:621483 737654 APPROVED
2006-11-20 LOC690994  similar to XLalphas protein      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-11-06 Gnas  GNAS complex locus    Guanine nucleotide-binding protein G-s, alpha subunit, Genbank no U51565  Name updated 625702 APPROVED
2002-08-07 Xlas  XLas protein      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Gnas  Guanine nucleotide-binding protein G-s, alpha subunit, Genbank no U51565      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease mutation of the human homolog causes pseudohypoparathyroidism (PHP) type Ia 730810
gene_function couple extracellular signals in signal transduction pathway, neurotransmission and synaptic vesicle life cycle 1357908