Slc2a4 (solute carrier family 2 member 4) - Rat Genome Database

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Gene: Slc2a4 (solute carrier family 2 member 4) Rattus norvegicus
Analyze
Symbol: Slc2a4
Name: solute carrier family 2 member 4
RGD ID: 2711
Description: Enables D-glucose uniporter activity. Involved in several processes, including cellular response to hypoxia; glucose import in response to insulin stimulus; and regulation of synaptic vesicle budding from presynaptic endocytic zone membrane. Acts upstream of or within with a positive effect on long-term memory. Acts upstream of or within with a negative effect on short-term memory. Acts upstream of or within learning or memory and positive regulation of brain-derived neurotrophic factor receptor signaling pathway. Located in several cellular components, including T-tubule; clathrin-coated pit; and cytoplasmic vesicle. Is active in presynapse. Biomarker of pulmonary hypertension. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human SLC2A4 (solute carrier family 2 member 4); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; facilitative sugar transporter mediated glucose transport pathway; insulin signaling pathway; INTERACTS WITH (R)-carnitine; (R,R)-tramadol; (S)-naringenin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: glucose transporter 4 insulin-responsive; glucose transporter 4, insulin-responsive; Glucose transporter 4, insuline-responsive; glucose transporter type 4, insulin-responsive; GLUT-4; Glut4; insulin responsive glucose transporter; MGC93607; solute carrier family 2 (facilitated glucose transporter) member 4; solute carrier family 2 (facilitated glucose transporter), member 4; solute carrier family 2 , member 4; solute carrier family 2, facilitated glucose transporter member 4; solute carrier family 2, member 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Bmd4
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81055,164,721 - 55,170,289 (-)NCBIGRCr8
GRCr8 Ensembl1055,164,721 - 55,170,270 (-)EnsemblGRCr8 Ensembl
mRatBN7.21054,666,015 - 54,671,581 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1054,666,015 - 54,671,565 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1059,328,590 - 59,334,093 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01058,817,163 - 58,822,666 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01054,324,426 - 54,329,928 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01056,552,921 - 56,558,562 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1056,552,983 - 56,558,487 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01056,298,102 - 56,303,687 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41056,786,705 - 56,792,209 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1053,819,953 - 53,825,446 (-)NCBICelera
RGSC_v3.11056,800,327 - 56,805,832 (-)NCBI
Cytogenetic Map10q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pronuciferine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-carnitine  (EXP)
(R,R)-tramadol  (EXP)
(S)-naringenin  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-thiazolidine-2,4-dione  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-chloroethanol  (ISO)
2-deoxy-D-glucose  (EXP,ISO)
3,3',5'-triiodo-L-thyronine  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (ISO)
3-phenylprop-2-enal  (EXP)
4'-Methoxychalcone  (ISO)
4-methyl-2-oxopentanoic acid  (ISO)
4-phenylbutyric acid  (EXP,ISO)
5-(tetradecyloxy)-2-furoic acid  (ISO)
6-propyl-2-thiouracil  (EXP)
9-cis,11-trans-octadecadienoic acid  (ISO)
9-cis-retinoic acid  (EXP)
acarbose  (EXP)
acrolein  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
AICA ribonucleotide  (EXP,ISO)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP)
alloxan  (EXP,ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
apigenin  (ISO)
arecoline  (EXP)
aristolochic acid A  (ISO)
arotinoid acid  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP,ISO)
asiatic acid  (EXP)
atorvastatin calcium  (ISO)
ATP  (ISO)
benzo[a]pyrene  (ISO)
berberine  (EXP)
beta-carotene  (ISO)
beta-D-glucosamine  (EXP,ISO)
beta-hexachlorocyclohexane  (EXP)
bexarotene  (ISO)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
boric acid  (ISO)
bupivacaine  (ISO)
butan-1-ol  (EXP)
butanal  (ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
cantharidin  (ISO)
capsaicin  (ISO)
CARBENOXOLONE  (EXP)
carbon nanotube  (ISO)
Chebulagic acid  (EXP)
chloroethene  (ISO)
chlorogenic acid  (ISO)
chloroquine  (EXP)
chlorpyrifos  (EXP)
chromium atom  (EXP,ISO)
chromium(3+) trichloride  (ISO)
chromium(6+)  (EXP)
ciguatoxin CTX1B  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (EXP,ISO)
CL316243  (EXP)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
corosolic acid  (ISO)
corticosterone  (EXP,ISO)
cortisone  (ISO)
cycloheximide  (EXP)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
DDE  (ISO)
DDT  (EXP,ISO)
decabromodiphenyl ether  (ISO)
Deoxycorticosterone acetate  (EXP)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
diazinon  (EXP)
diethyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimercaprol  (EXP)
dimethylarsinic acid  (EXP)
dioxygen  (ISO)
divanadium pentaoxide  (ISO)
dopamine  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
endrin  (ISO)
ethanol  (ISO)
eugenol  (EXP,ISO)
fenbendazole  (ISO)
fenoldopam  (EXP)
ferulic acid  (ISO)
fipronil  (ISO)
fisetin  (ISO)
fructose  (EXP,ISO)
fulvestrant  (EXP)
Fusaric acid  (ISO)
gallein  (EXP)
genistein  (EXP,ISO)
Gingerenone A  (EXP)
gingerol  (ISO)
ginsenoside Re  (EXP,ISO)
glucose  (EXP,ISO)
glutathione disulfide  (ISO)
glyburide  (EXP)
glycyrrhizinic acid  (ISO)
glyphosate  (EXP)
gypenoside LXXV  (ISO)
haloperidol  (ISO)
hemin  (EXP)
heptachlor  (EXP)
hesperidin  (ISO)
hexachlorobenzene  (EXP,ISO)
hexadecanoic acid  (EXP,ISO)
hydrazines  (ISO)
imidacloprid  (EXP,ISO)
imisopasem manganese  (EXP)
Indeno[1,2,3-cd]pyrene  (ISO)
indinavir  (EXP)
indometacin  (ISO)
isoliquiritigenin  (ISO)
isoprenaline  (EXP)
isoscutellarein  (ISO)
isotretinoin  (EXP)
ivermectin  (ISO)
kaempferol  (ISO)
kynurenine  (ISO)
L-ascorbic acid  (EXP,ISO)
L-citrulline  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
letrozole  (EXP)
lipopolysaccharide  (ISO)
luteolin  (ISO)
LY294002  (ISO)
mangiferin  (EXP,ISO)
melatonin  (EXP,ISO)
meldonium  (ISO)
mercury atom  (EXP)
mercury dichloride  (ISO)
mercury(0)  (EXP)
metformin  (EXP,ISO)
methapyrilene  (ISO)
methimazole  (EXP)
methyl pyruvate  (ISO)
methylmercury chloride  (ISO)
mirtazapine  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monomethyl succinate  (ISO)
monosodium L-glutamate  (EXP,ISO)
myrtenal  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (ISO)
naloxone  (EXP)
naringin  (ISO)
nerolidol  (EXP)
nicotinamide  (EXP)
nicotinic acid  (EXP)
Niflumic acid  (ISO)
nimesulide  (ISO)
okadaic acid  (ISO)
olanzapine  (ISO)
orientin  (ISO)
ozone  (EXP)
paracetamol  (EXP)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (ISO)
phenylarsine oxide  (EXP,ISO)
picolinic acid  (ISO)
pifithrin-alpha hydrobromide  (EXP)
pioglitazone  (EXP)
pirinixic acid  (ISO)
platycodin D  (ISO)
plumbagin  (EXP)
pravastatin  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
prochloraz  (ISO)
procyanidin B1  (ISO)
progesterone  (EXP)
propanal  (ISO)
prostaglandin J2  (EXP)
psoralen  (EXP)
Pyridostigmine bromide  (ISO)
pyruvic acid  (ISO)
quercetin  (EXP,ISO)
raffinose  (EXP,ISO)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
rimonabant  (ISO)
rofecoxib  (ISO)
Rutamarin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sarpogrelate  (EXP)
sildenafil citrate  (ISO)
silibinin  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium azide  (ISO)
sodium chloride  (EXP)
sodium dichromate  (ISO)
streptozocin  (EXP,ISO)
sucrose  (EXP,ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
taurine  (EXP)
tauroursodeoxycholic acid  (EXP,ISO)
testosterone  (ISO)
theaflavin  (ISO)
thiazolidinediones  (ISO)
thyroxine  (ISO)
titanium dioxide  (ISO)
tolylfluanid  (ISO)
tramadol  (EXP)
trans-caffeic acid  (ISO)
trans-cinnamic acid  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP,ISO)
triclosan  (ISO)
Triptolide  (EXP,ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
U-73122  (EXP)
urethane  (ISO)
Ursonic acid  (ISO)
valproic acid  (ISO)
valsartan  (EXP)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vancomycin  (ISO)
venlafaxine hydrochloride  (EXP)
verapamil  (EXP)
vinclozolin  (EXP)
vitamin D  (ISO)
vitamin E  (EXP)
wogonin  (ISO)
wortmannin  (EXP,ISO)
zaragozic acid A  (EXP,ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Identification and characterization of two distinct intracellular GLUT4 pools in rat skeletal muscle: evidence for an endosomal and an insulin-sensitive GLUT4 compartment. Aledo JC, etal., Biochem J. 1997 Aug 1;325 ( Pt 3):727-32.
2. GLUT4 Mobilization Supports Energetic Demands of Active Synapses. Ashrafi G, etal., Neuron. 2017 Feb 8;93(3):606-615.e3. doi: 10.1016/j.neuron.2016.12.020. Epub 2017 Jan 19.
3. Identification of a novel gene encoding an insulin-responsive glucose transporter protein. Birnbaum MJ Cell 1989 Apr 21;57(2):305-15.
4. The cellular fate of glucose and its relevance in type 2 diabetes. Bouche C, etal., Endocr Rev. 2004 Oct;25(5):807-30.
5. Upregulation of GLUT-4 in right ventricle of rats with monocrotaline-induced pulmonary hypertension. Broderick TL and King TM, Med Sci Monit. 2008 Dec;14(12):BR261-4.
6. Insulin increases the association of Akt-2 with Glut4-containing vesicles. Calera MR, etal., J Biol Chem. 1998 Mar 27;273(13):7201-4.
7. A glucose transport protein expressed predominately in insulin-responsive tissues. Charron MJ, etal., Proc Natl Acad Sci U S A 1989 Apr;86(8):2535-9.
8. Insulin and okadaic acid induce Rab4 redistribution in adipocytes. Cormont M, etal., J Biol Chem. 1993 Sep 15;268(26):19491-7.
9. Reduced glucose transporter GLUT4 in skeletal muscle predicts insulin resistance in non-diabetic chronic heart failure patients independently of body composition. Doehner W, etal., Int J Cardiol. 2008 Sep 6.
10. Expression of insulin-responsive glucose transporter GLUT4 mRNA in the rat brain and spinal cord: an in situ hybridization study. El Messari S, etal., J Chem Neuroanat 2002 Nov;24(4):225-42.
11. Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC). Foster LJ, etal., J Proteome Res. 2006 Jan;5(1):64-75.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
14. Transient changes in four GLUT4 compartments in rat adipocytes during the transition, insulin-stimulated to basal: implications for the GLUT4 trafficking pathway. Hah JS, etal., Biochemistry 2002 Dec 3;41(48):14364-71.
15. Pre-germinated brown rice extract ameliorates high-fat diet-induced metabolic syndrome. Hao CL, etal., J Food Biochem. 2019 Mar;43(3):e12769. doi: 10.1111/jfbc.12769. Epub 2019 Jan 13.
16. Cell surface labeling of glucose transporter isoform GLUT4 by bis-mannose photolabel. Correlation with stimulation of glucose transport in rat adipose cells by insulin and phorbol ester. Holman GD, etal., J Biol Chem. 1990 Oct 25;265(30):18172-9.
17. Molecular cloning and characterization of an insulin-regulatable glucose transporter. James DE, etal., Nature. 1989 Mar 2;338(6210):83-7. doi: 10.1038/338083a0.
18. Characterization of rat Glut4 glucose transporter expressed in the yeast Saccharomyces cerevisiae: comparison with Glut1 glucose transporter. Kasahara T and Kasahara M, Biochim Biophys Acta 1997 Feb 21;1324(1):111-9.
19. Anti-diabetic effects of new herbal formula in neonatally streptozotocin-induced diabetic rats. Kim JO, etal., Biol Pharm Bull. 2009 Mar;32(3):421-6.
20. REDOX REGULATION OF ISCHEMIC PRECONDITIONING IS MEDIATED BY THE DIFFERENTIAL ACTIVATION OF CAVEOLINS AND THEIR ASSOCIATION WITH eNOS AND GLUT-4. Koneru S, etal., Am J Physiol Heart Circ Physiol. 2007 Feb 2;.
21. GLUT-4 translocation in skeletal muscle studied with a cell-free assay: involvement of phospholipase D. Kristiansen S, etal., Am J Physiol Endocrinol Metab 2001 Sep;281(3):E608-18.
22. Akt-2 binds to Glut4-containing vesicles and phosphorylates their component proteins in response to insulin. Kupriyanova TA and Kandror KV, J Biol Chem. 1999 Jan 15;274(3):1458-64.
23. Analysis of the gene sequences of the insulin receptor and the insulin-sensitive glucose transporter (GLUT-4) in patients with common-type non-insulin-dependent diabetes mellitus. Kusari J, etal., J Clin Invest. 1991 Oct;88(4):1323-30.
24. The GLUT4 code. Larance M, etal., Mol Endocrinol. 2008 Feb;22(2):226-33. Epub 2007 Aug 23.
25. Translocation of the Na+/H+ exchanger 1 (NHE1) in cardiomyocyte responses to insulin and energy-status signalling. Lawrence SP, etal., Biochem J. 2010 Dec 15;432(3):515-23. doi: 10.1042/BJ20100717.
26. Role of insulin-dependent cortical fodrin/spectrin remodeling in glucose transporter 4 translocation in rat adipocytes. Liu L, etal., Mol Biol Cell. 2006 Oct;17(10):4249-56. Epub 2006 Jul 26.
27. MicroRNA-223 regulates Glut4 expression and cardiomyocyte glucose metabolism. Lu H, etal., Cardiovasc Res. 2010 Jun 1;86(3):410-20. doi: 10.1093/cvr/cvq010. Epub 2010 Jan 15.
28. Vp165 and GLUT4 share similar vesicle pools along their trafficking pathways in rat adipose cells. Malide D, etal., FEBS Lett. 1997 Jun 16;409(3):461-8.
29. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
30. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
31. Mitochondrial genome modulates myocardial Akt/Glut/HK salvage pathway in spontaneously hypertensive rats adapted to chronic hypoxia. Nedvedova I, etal., Physiol Genomics. 2018 Jul 1;50(7):532-541. doi: 10.1152/physiolgenomics.00040.2017. Epub 2018 Apr 20.
32. Co-localization of GLUT1 and GLUT4 in the blood-brain barrier of the rat ventromedial hypothalamus. Ngarmukos C, etal., Brain Res. 2001 May 4;900(1):1-8. doi: 10.1016/s0006-8993(01)02184-9.
33. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
34. Novel Roles for the Insulin-Regulated Glucose Transporter-4 in Hippocampally Dependent Memory. Pearson-Leary J and McNay EC, J Neurosci. 2016 Nov 23;36(47):11851-11864. doi: 10.1523/JNEUROSCI.1700-16.2016.
35. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
36. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
37. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
38. GOA pipeline RGD automated data pipeline
39. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
40. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
41. Parallel changes in Glut 4 and Rab4 movements in two insulin-resistant states. Ricort JM, etal., FEBS Lett. 1994 Jun 20;347(1):42-4.
42. Exercise training, glucose transporters, and glucose transport in rat skeletal muscles. Rodnick KJ, etal., Am J Physiol. 1992 Jan;262(1 Pt 1):C9-14.
43. Coronary artery disease is associated with higher epicardial retinol-binding protein 4 (RBP4) and lower glucose transporter (GLUT) 4 levels in epicardial and subcutaneous adipose tissue. Salgado-Somoza A, etal., Clin Endocrinol (Oxf). 2012 Jan;76(1):51-8. doi: 10.1111/j.1365-2265.2011.04140.x.
44. The glucose transporter families SGLT and GLUT: molecular basis of normal and aberrant function. Scheepers A, etal., JPEN J Parenter Enteral Nutr. 2004 Sep-Oct;28(5):364-71.
45. Treadmill exercise training fails to reverse defects in glucose, insulin and muscle GLUT4 content in the db/db mouse model of diabetes. Sennott J, etal., Pathophysiology. 2008 Oct;15(3):173-9. Epub 2008 Jul 23.
46. Differential effects of insulin and exercise on Rab4 distribution in rat skeletal muscle. Sherman LA, etal., Endocrinology. 1996 Jan;137(1):266-73.
47. Past-A, a novel proton-associated sugar transporter, regulates glucose homeostasis in the brain. Shimokawa N, etal., J Neurosci 2002 Nov 1;22(21):9160-5.
48. Translocation of the glucose transporter GLUT4 in cardiac myocytes of the rat. Slot JW, etal., Proc Natl Acad Sci U S A. 1991 Sep 1;88(17):7815-9.
49. SNAP-23 participates in SNARE complex assembly in rat adipose cells. St-Denis JF, etal., Biochem J 1999 Mar 15;338 ( Pt 3):709-15.
50. Effect of transient ischemia on the expression of glucose transporters GLUT-1 and GLUT-4 in rat myocardium. Tardy-Cantalupi I, etal., J Mol Cell Cardiol. 1999 May;31(5):1143-55.
51. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
52. A Glut4-vesicle marker protein, insulin-responsive aminopeptidase, is localized in a novel vesicular compartment in PC12 cells. Thoidis G and Kandror KV, Traffic. 2001 Aug;2(8):577-87.
53. Insulin-induced translocation of the glucose transporter GLUT4 in cardiac muscle: studies on the role of small-molecular-mass GTP-binding proteins. Uphues I, etal., Biochem J. 1994 Jul 1;301 ( Pt 1):177-82.
54. Changes in FAT/CD36, UCP2, UCP3 and GLUT4 gene expression during lipid infusion in rat skeletal and heart muscle. Vettor R, etal., Int J Obes Relat Metab Disord 2002 Jun;26(6):838-47.
55. Effect of GLP-1 treatment on GLUT2 and GLUT4 expression in type 1 and type 2 rat diabetic models. Villanueva-Penacarrillo ML, etal., Endocrine 2001 Jul;15(2):241-8.
56. GLUT4 translocation: the last 200 nanometers. Watson RT and Pessin JE, Cell Signal. 2007 Nov;19(11):2209-17. Epub 2007 Jun 21.
57. Insulin-stimulated cytosol alkalinization facilitates optimal activation of glucose transport in cardiomyocytes. Yang J, etal., Am J Physiol Endocrinol Metab. 2002 Dec;283(6):E1299-307. Epub 2002 Aug 13.
58. Insulin action on glucose transporters through molecular switches, tracks and tethers. Zaid H, etal., Biochem J. 2008 Jul 15;413(2):201-15.
59. The diabetogenic effects of excessive ethanol: reducing beta-cell mass, decreasing phosphatidylinositol 3-kinase activity and GLUT-4 expression in rats. Zhao LN, etal., Br J Nutr. 2009 May;101(10):1467-73. Epub 2008 Oct 30.
Additional References at PubMed
PMID:1618860   PMID:1651337   PMID:7545962   PMID:7720644   PMID:10394363   PMID:10444069   PMID:11689011   PMID:11718554   PMID:11879194   PMID:11919487   PMID:11934664   PMID:11982503  
PMID:11989821   PMID:12002265   PMID:12079879   PMID:12097321   PMID:12189582   PMID:12297296   PMID:12467732   PMID:12477932   PMID:12490950   PMID:12496137   PMID:12531786   PMID:12556481  
PMID:12631717   PMID:12637564   PMID:12777391   PMID:12782634   PMID:12799316   PMID:12832401   PMID:12917015   PMID:14562105   PMID:14741039   PMID:15015152   PMID:15117888   PMID:15182197  
PMID:15247264   PMID:15247266   PMID:15466888   PMID:15489334   PMID:15494613   PMID:15546921   PMID:15557332   PMID:15591781   PMID:15625086   PMID:15729573   PMID:15734836   PMID:15764607  
PMID:15797240   PMID:15800058   PMID:15857891   PMID:15866888   PMID:15905322   PMID:15935991   PMID:15955810   PMID:16024167   PMID:16096283   PMID:16154100   PMID:16273324   PMID:16319996  
PMID:16418206   PMID:16455755   PMID:16622606   PMID:16647043   PMID:16670091   PMID:16774991   PMID:16787385   PMID:16902066   PMID:16985263   PMID:17003038   PMID:17003346   PMID:17189352  
PMID:17198541   PMID:17416968   PMID:17426391   PMID:17532293   PMID:17550999   PMID:17666490   PMID:17709177   PMID:18067996   PMID:18084728   PMID:18162526   PMID:18163380   PMID:18164589  
PMID:18167317   PMID:18227281   PMID:18326493   PMID:18335580   PMID:18343214   PMID:18435821   PMID:18492766   PMID:18511518   PMID:18617516   PMID:18619553   PMID:18647882   PMID:18650314  
PMID:18692545   PMID:18701652   PMID:18797165   PMID:18923160   PMID:19155211   PMID:19177156   PMID:19188436   PMID:19228889   PMID:19273501   PMID:19386915   PMID:19478182   PMID:19509061  
PMID:19523145   PMID:19546347   PMID:19563078   PMID:19590752   PMID:19615701   PMID:19675279   PMID:19679110   PMID:19706162   PMID:19720047   PMID:19722251   PMID:19724054   PMID:19864425  
PMID:19940039   PMID:20024634   PMID:20173759   PMID:20363751   PMID:20371884   PMID:20383279   PMID:20460104   PMID:20582536   PMID:20584641   PMID:20698833   PMID:20739464   PMID:20816091  
PMID:20938990   PMID:21029425   PMID:21041651   PMID:21332027   PMID:21347724   PMID:21454690   PMID:21773965   PMID:21788123   PMID:21799128   PMID:21907143   PMID:22015196   PMID:22079207  
PMID:22079346   PMID:22125125   PMID:22136156   PMID:22247557   PMID:22319399   PMID:22488520   PMID:22610671   PMID:22897936   PMID:22918957   PMID:22960630   PMID:22996137   PMID:23035738  
PMID:23041416   PMID:23049745   PMID:23104384   PMID:23238530   PMID:23285235   PMID:23292098   PMID:23355380   PMID:23427263   PMID:23520472   PMID:23625195   PMID:23640896   PMID:23652351  
PMID:23715867   PMID:23717693   PMID:23750537   PMID:23757167   PMID:23940308   PMID:24023607   PMID:24130215   PMID:24326422   PMID:24329691   PMID:24361184   PMID:24382486   PMID:24478457  
PMID:24500986   PMID:24708213   PMID:24801390   PMID:24895286   PMID:25025572   PMID:25086780   PMID:25097857   PMID:25445608   PMID:25470523   PMID:25491725   PMID:25666964   PMID:25713812  
PMID:26240143   PMID:26503060   PMID:26538022   PMID:26629404   PMID:26784579   PMID:26854998   PMID:27041232   PMID:27133433   PMID:27295130   PMID:27322312   PMID:27354378   PMID:27614316  
PMID:27739494   PMID:27783302   PMID:27797912   PMID:28177731   PMID:28374891   PMID:28495883   PMID:28500736   PMID:28570686   PMID:28648676   PMID:28808062   PMID:29247648   PMID:29794037  
PMID:29802324   PMID:29806984   PMID:30170066   PMID:30296507   PMID:30528377   PMID:30837370   PMID:31594761   PMID:31669265   PMID:31767340   PMID:31914838   PMID:32024865   PMID:32454459  
PMID:32542704   PMID:33085741   PMID:33393983   PMID:33526980   PMID:33724628   PMID:34206320   PMID:34785192   PMID:35502572   PMID:37073948   PMID:37673038   PMID:37715078   PMID:38950736  
PMID:39240727  


Genomics

Comparative Map Data
Slc2a4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81055,164,721 - 55,170,289 (-)NCBIGRCr8
GRCr8 Ensembl1055,164,721 - 55,170,270 (-)EnsemblGRCr8 Ensembl
mRatBN7.21054,666,015 - 54,671,581 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1054,666,015 - 54,671,565 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1059,328,590 - 59,334,093 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01058,817,163 - 58,822,666 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01054,324,426 - 54,329,928 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01056,552,921 - 56,558,562 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1056,552,983 - 56,558,487 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01056,298,102 - 56,303,687 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41056,786,705 - 56,792,209 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1053,819,953 - 53,825,446 (-)NCBICelera
RGSC_v3.11056,800,327 - 56,805,832 (-)NCBI
Cytogenetic Map10q24NCBI
SLC2A4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38177,281,718 - 7,288,257 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl177,281,718 - 7,288,257 (+)EnsemblGRCh38hg38GRCh38
GRCh37177,185,037 - 7,191,576 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36177,125,778 - 7,132,091 (+)NCBINCBI36Build 36hg18NCBI36
Build 34177,125,834 - 7,131,125NCBI
Celera177,209,701 - 7,216,014 (+)NCBICelera
Cytogenetic Map17p13.1NCBI
HuRef177,076,412 - 7,082,727 (+)NCBIHuRef
CHM1_1177,193,837 - 7,200,150 (+)NCBICHM1_1
T2T-CHM13v2.0177,182,662 - 7,189,200 (+)NCBIT2T-CHM13v2.0
Slc2a4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391169,833,112 - 69,839,040 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1169,833,365 - 69,839,014 (-)EnsemblGRCm39 Ensembl
GRCm381169,942,286 - 69,948,216 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1169,942,539 - 69,948,188 (-)EnsemblGRCm38mm10GRCm38
MGSCv371169,755,788 - 69,761,692 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361169,758,738 - 69,764,329 (-)NCBIMGSCv36mm8
Celera1177,490,257 - 77,496,161 (-)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1142.93NCBI
Slc2a4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554679,630,304 - 9,636,005 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554679,630,304 - 9,636,005 (-)NCBIChiLan1.0ChiLan1.0
SLC2A4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21914,875,384 - 14,882,068 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11716,841,235 - 16,847,919 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0177,312,605 - 7,319,430 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1177,299,966 - 7,306,344 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl177,299,966 - 7,306,344 (+)Ensemblpanpan1.1panPan2
SLC2A4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1532,238,095 - 32,244,022 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl532,238,095 - 32,244,021 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha532,376,140 - 32,382,065 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0532,343,488 - 32,349,420 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl532,342,566 - 32,350,065 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1532,308,943 - 32,314,868 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0532,267,746 - 32,273,663 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0532,444,733 - 32,450,658 (+)NCBIUU_Cfam_GSD_1.0
Slc2a4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560247,093,063 - 47,099,869 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936595567,219 - 574,059 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936595567,267 - 574,051 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC2A4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1252,628,450 - 52,634,967 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11252,628,746 - 52,634,965 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21254,810,360 - 54,816,580 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC2A4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1166,654,626 - 6,660,640 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl166,654,608 - 6,661,495 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605914,750,453 - 14,756,535 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc2a4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247869,902,509 - 9,909,684 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247869,903,176 - 9,908,953 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc2a4
42 total Variants
miRNA Target Status (No longer updated)

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir133brno-miR-133b-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI19720047
Mir133a1rno-miR-133a-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI19720047

Predicted Target Of
Summary Value
Count of predictions:82
Count of miRNA genes:71
Interacting mature miRNAs:73
Transcripts:ENSRNOT00000023256
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103589345164140567Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103621155669161158Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
152025227Bw195Body weight QTL 1955.73body mass (VT:0001259)104748901769161158Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
152025224Bw193Body weight QTL 1936.47body mass (VT:0001259)105216243375582749Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1578762Toxo1Toxoplasma gondii resistance QTL 1brain integrity trait (VT:0010579)percentage of study population displaying Toxoplasma gondii brain cysts at a point in time (CMO:0002028)105269900459876693Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102183375861843633Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103589326364653589Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102980091064653589Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
2306787Ean3Experimental allergic neuritis QTL 33.1nervous system integrity trait (VT:0010566)body weight loss (CMO:0001399)105429622767476781Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
1354585Eae18aExperimental allergic encephalomyelitis QTL 18a7.50.0004nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)105429622758944345Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102702353561843633Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)103950348784503487Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
D10Uwm1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21054,671,889 - 54,672,047 (+)MAPPERmRatBN7.2
Rnor_6.01056,558,857 - 56,559,014NCBIRnor6.0
Rnor_5.01056,303,976 - 56,304,133UniSTSRnor5.0
RGSC_v3.41056,792,579 - 56,792,736UniSTSRGSC3.4
RGSC_v3.41056,792,578 - 56,792,736RGDRGSC3.4
Celera1053,825,816 - 53,825,973UniSTS
RGSC_v3.11056,806,201 - 56,806,359RGD
Cytogenetic Map10q24UniSTS
D10Wox40  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21054,671,851 - 54,672,003 (+)MAPPERmRatBN7.2
Rnor_6.01056,558,819 - 56,558,970NCBIRnor6.0
Rnor_5.01056,303,938 - 56,304,089UniSTSRnor5.0
RGSC_v3.41056,792,541 - 56,792,692UniSTSRGSC3.4
Celera1053,825,778 - 53,825,929UniSTS
Cytogenetic Map10q24UniSTS
D10Wox39  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21054,673,181 - 54,673,268 (+)MAPPERmRatBN7.2
Rnor_6.01056,560,149 - 56,560,235NCBIRnor6.0
Rnor_5.01056,305,268 - 56,305,354UniSTSRnor5.0
RGSC_v3.41056,793,871 - 56,793,957UniSTSRGSC3.4
RGSC_v3.41056,803,054 - 56,803,140UniSTSRGSC3.4
Celera1053,827,108 - 53,827,194UniSTS
Cytogenetic Map10q24UniSTS
Slc2a4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21054,666,184 - 54,666,315 (+)MAPPERmRatBN7.2
Rnor_6.01056,553,153 - 56,553,283NCBIRnor6.0
Rnor_5.01056,298,272 - 56,298,402UniSTSRnor5.0
RGSC_v3.41056,786,875 - 56,787,005UniSTSRGSC3.4
Celera1053,820,123 - 53,820,253UniSTS
Cytogenetic Map10q24UniSTS
D10Wox39  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21054,673,181 - 54,673,269 (+)MAPPERmRatBN7.2
Rnor_6.01056,560,149 - 56,560,236NCBIRnor6.0
Rnor_5.01056,305,268 - 56,305,355UniSTSRnor5.0
RGSC_v3.41056,803,053 - 56,803,140UniSTSRGSC3.4
RGSC_v3.41056,793,871 - 56,793,958UniSTSRGSC3.4
Celera1053,827,108 - 53,827,195UniSTS
Cytogenetic Map10q24UniSTS
UniSTS:547075  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21054,666,204 - 54,667,679 (+)MAPPERmRatBN7.2
Rnor_6.01056,553,173 - 56,554,647NCBIRnor6.0
Rnor_5.01056,298,292 - 56,299,766UniSTSRnor5.0
Celera1053,820,143 - 53,821,617UniSTS
Cytogenetic Map10q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 11 49 113 89 88 57 25 57 6 216 97 11 93 45 60 31 9 9

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001430054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001430055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_012751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006246596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC085757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D28561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233419 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J04524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ696745 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L36125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M25482 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  PP731918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  PP731919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  PP731920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  PP731921 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  PP731922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  PP731923 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  PP731924 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  PP731925 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  PP731926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  PP731927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  PP731928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  PP731929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X14771 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000023256   ⟹   ENSRNOP00000023256
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1055,164,729 - 55,170,270 (-)Ensembl
mRatBN7.2 Ensembl1054,666,023 - 54,671,565 (-)Ensembl
Rnor_6.0 Ensembl1056,552,983 - 56,558,487 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095666   ⟹   ENSRNOP00000090027
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1055,166,125 - 55,170,270 (-)Ensembl
mRatBN7.2 Ensembl1054,667,419 - 54,671,565 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000113573   ⟹   ENSRNOP00000094954
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1055,164,721 - 55,168,868 (-)Ensembl
mRatBN7.2 Ensembl1054,666,015 - 54,670,162 (-)Ensembl
RefSeq Acc Id: NM_012751   ⟹   NP_036883
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81055,164,721 - 55,170,225 (-)NCBI
mRatBN7.21054,666,015 - 54,671,520 (-)NCBI
Rnor_6.01056,552,983 - 56,558,487 (-)NCBI
Rnor_5.01056,298,102 - 56,303,687 (-)NCBI
RGSC_v3.41056,786,705 - 56,792,209 (-)RGD
Celera1053,819,953 - 53,825,446 (-)RGD
Sequence:
RefSeq Acc Id: XM_006246596   ⟹   XP_006246658
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81055,164,723 - 55,170,285 (-)NCBI
mRatBN7.21054,666,851 - 54,671,581 (-)NCBI
Rnor_6.01056,552,921 - 56,558,562 (-)NCBI
Rnor_5.01056,298,102 - 56,303,687 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063268455   ⟹   XP_063124525
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81055,165,991 - 55,170,289 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001416983 (Get FASTA)   NCBI Sequence Viewer  
  NP_001416984 (Get FASTA)   NCBI Sequence Viewer  
  NP_036883 (Get FASTA)   NCBI Sequence Viewer  
  XP_006246658 (Get FASTA)   NCBI Sequence Viewer  
  XP_063124525 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41451 (Get FASTA)   NCBI Sequence Viewer  
  AAA41453 (Get FASTA)   NCBI Sequence Viewer  
  AAA65751 (Get FASTA)   NCBI Sequence Viewer  
  AAH85757 (Get FASTA)   NCBI Sequence Viewer  
  AID57766 (Get FASTA)   NCBI Sequence Viewer  
  BAA05911 (Get FASTA)   NCBI Sequence Viewer  
  CAA32879 (Get FASTA)   NCBI Sequence Viewer  
  EDM04935 (Get FASTA)   NCBI Sequence Viewer  
  EDM04936 (Get FASTA)   NCBI Sequence Viewer  
  EDM04937 (Get FASTA)   NCBI Sequence Viewer  
  EDM04938 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000023256
  ENSRNOP00000023256.3
  ENSRNOP00000090027
GenBank Protein P19357 (Get FASTA)   NCBI Sequence Viewer  
  XAF83747 (Get FASTA)   NCBI Sequence Viewer  
  XAF83748 (Get FASTA)   NCBI Sequence Viewer  
  XAF83749 (Get FASTA)   NCBI Sequence Viewer  
  XAF83750 (Get FASTA)   NCBI Sequence Viewer  
  XAF83751 (Get FASTA)   NCBI Sequence Viewer  
  XAF83752 (Get FASTA)   NCBI Sequence Viewer  
  XAF83753 (Get FASTA)   NCBI Sequence Viewer  
  XAF83754 (Get FASTA)   NCBI Sequence Viewer  
  XAF83755 (Get FASTA)   NCBI Sequence Viewer  
  XAF83756 (Get FASTA)   NCBI Sequence Viewer  
  XAF83757 (Get FASTA)   NCBI Sequence Viewer  
  XAF83758 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036883   ⟸   NM_012751
- UniProtKB: P97900 (UniProtKB/Swiss-Prot),   P19357 (UniProtKB/Swiss-Prot),   A6HFY2 (UniProtKB/TrEMBL),   A0A8I6B1R2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246658   ⟸   XM_006246596
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSRNOP00000023256   ⟸   ENSRNOT00000023256
Ensembl Acc Id: ENSRNOP00000090027   ⟸   ENSRNOT00000095666
Ensembl Acc Id: ENSRNOP00000094954   ⟸   ENSRNOT00000113573
RefSeq Acc Id: XP_063124525   ⟸   XM_063268455
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AM71 (UniProtKB/TrEMBL)
Protein Domains
Major facilitator superfamily (MFS) profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P19357-F1-model_v2 AlphaFold P19357 1-509 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697339
Promoter ID:EPDNEW_R7864
Type:multiple initiation site
Name:Slc2a4_1
Description:solute carrier family 2 member 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01056,558,519 - 56,558,579EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2711 AgrOrtholog
BioCyc Gene G2FUF-24499 BioCyc
Ensembl Genes ENSRNOG00000017226 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000023256 ENTREZGENE
  ENSRNOT00000023256.6 UniProtKB/Swiss-Prot
  ENSRNOT00000095666 ENTREZGENE
Gene3D-CATH 1.20.1250.20 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7192278 IMAGE-MGC_LOAD
InterPro Glc_transpt_4 UniProtKB/Swiss-Prot
  GLUT UniProtKB/Swiss-Prot
  MFS_dom UniProtKB/Swiss-Prot
  MFS_sugar_transport-like UniProtKB/Swiss-Prot
  MFS_trans_sf UniProtKB/Swiss-Prot
  Sugar/inositol_transpt UniProtKB/Swiss-Prot
  Sugar_transporter_CS UniProtKB/Swiss-Prot
KEGG Report rno:25139 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93607 IMAGE-MGC_LOAD
NCBI Gene 25139 ENTREZGENE
PANTHER PTHR23503 UniProtKB/Swiss-Prot
  SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 4 UniProtKB/Swiss-Prot
Pfam Sugar_tr UniProtKB/Swiss-Prot
PhenoGen Slc2a4 PhenoGen
PRINTS GLUCTRSPORT4 UniProtKB/Swiss-Prot
  SUGRTRNSPORT UniProtKB/Swiss-Prot
PROSITE MFS UniProtKB/Swiss-Prot
  SUGAR_TRANSPORT_1 UniProtKB/Swiss-Prot
  SUGAR_TRANSPORT_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017226 RatGTEx
Superfamily-SCOP SSF103473 UniProtKB/Swiss-Prot
TIGR TC205760
UniProt A0A8I6AM71 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6B1R2 ENTREZGENE, UniProtKB/TrEMBL
  A6HFY0_RAT UniProtKB/TrEMBL
  A6HFY2 ENTREZGENE, UniProtKB/TrEMBL
  A6HFY3_RAT UniProtKB/TrEMBL
  GLUT4_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  P97900 ENTREZGENE
UniProt Secondary P97900 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-24 Slc2a4  solute carrier family 2 member 4  Slc2a4  solute carrier family 2 (facilitated glucose transporter), member 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Slc2a4  solute carrier family 2 (facilitated glucose transporter), member 4    solute carrier family 2 , member 4  Name updated 1299863 APPROVED
2002-11-06 Slc2a4  solute carrier family 2 , member 4  Glut4  Glucose transporter 4, insuline-responsive  Symbol and Name updated 625702 APPROVED
2002-06-10 Glut4  Glucose transporter 4, insuline-responsive      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation Glut4 intracellular trafficking and localization is regulated by insulin 727471