Glo1 (glyoxalase 1) - Rat Genome Database

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Gene: Glo1 (glyoxalase 1) Rattus norvegicus
Analyze
Symbol: Glo1
Name: glyoxalase 1
RGD ID: 2702
Description: Enables lactoylglutathione lyase activity. Involved in glutathione metabolic process and methylglyoxal metabolic process. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Human ortholog(s) of this gene implicated in autistic disorder; diabetic retinopathy; end stage renal disease; type 2 diabetes mellitus; and vascular disease. Orthologous to human GLO1 (glyoxalase I); PARTICIPATES IN glyoxalase metabolic pathway; Leigh disease pathway; primary hyperoxaluria type 2 pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: aldoketomutase; glx I; glyoxalase I; glyoxylase 1; ketone-aldehyde mutase; lactoylglutathione lyase; methylglyoxalase; S-D-lactoylglutathione methylglyoxal lyase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8208,665,061 - 8,683,095 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl208,665,061 - 8,683,191 (-)EnsemblGRCr8
mRatBN7.2208,663,617 - 8,681,661 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl208,662,801 - 8,681,649 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx209,355,240 - 9,374,295 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0208,716,413 - 8,735,468 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0209,192,465 - 9,211,480 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0209,273,589 - 9,291,608 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl209,273,594 - 9,291,610 (-)Ensemblrn6Rnor6.0
Rnor_5.02011,461,655 - 11,479,690 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4208,900,984 - 8,919,001 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2010,191,302 - 10,209,289 (-)NCBICelera
RGSC_v3.1208,901,210 - 8,919,228 (-)NCBI
Cytogenetic Map20p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-trans-(S)-allethrin  (ISO)
(S)-colchicine  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,4-dihydroxybenzaldehyde  (ISO)
3,4-dihydroxybenzoic acid  (ISO)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxycoumarin  (ISO)
acemetacin  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-D-galactose  (ISO)
AM-251  (EXP)
aminoguanidine  (EXP,ISO)
antirheumatic drug  (ISO)
apocynin  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
Benoxacor  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
Bergenin  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chlorophyllin  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
clobetasol  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocin-1  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
DDE  (ISO)
desferrioxamine B  (ISO)
diarsenic trioxide  (ISO)
dicrotophos  (ISO)
dihydroxyacetone  (ISO)
dioxygen  (ISO)
diuron  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
ferric ammonium citrate  (ISO)
fluoxetine  (ISO)
galactose  (ISO)
galangin  (ISO)
gliclazide  (EXP)
glucose  (EXP,ISO)
glycolaldehyde  (EXP)
haloperidol  (ISO)
Honokiol  (ISO)
indometacin  (ISO)
inulin  (ISO)
isoniazide  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
limonene  (ISO)
lipopolysaccharide  (ISO)
Magnolol  (EXP)
mangiferin  (EXP)
Mesaconitine  (EXP)
methamphetamine  (EXP)
methidathion  (ISO)
methylglyoxal  (EXP,ISO)
monascin  (ISO)
Morroniside  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
nicotinamide  (EXP)
okadaic acid  (ISO)
oxaliplatin  (EXP)
p-menthan-3-ol  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
pirinixic acid  (ISO)
pterostilbene  (ISO)
quercetin  (ISO)
resveratrol  (EXP,ISO)
sarin  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
streptozocin  (EXP)
sulforaphane  (ISO)
sulindac  (ISO)
temozolomide  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
titanium dioxide  (ISO)
tolmetin  (ISO)
topotecan  (EXP)
trichloroethene  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (EXP,ISO)
uranium atom  (ISO)
valproic acid  (ISO)
vanillin  (ISO)
zomepirac  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IEA,ISO)
nucleoplasm  (IEA,ISO)
plasma membrane  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Distribution of glyoxalase I polymorphism among Zuni Indians: the Zuni Kidney Project. Degaffe GH, etal., J Diabetes Complications. 2008 Jul-Aug;22(4):267-72. doi: 10.1016/j.jdiacomp.2007.06.010. Epub 2008 Apr 16.
2. A419C (E111A) polymorphism of the glyoxalase I gene and vascular complications in chronic hemodialysis patients. Kalousova M, etal., Ann N Y Acad Sci. 2008 Apr;1126:268-71. Epub 2007 Dec 13.
3. Genetic predisposition to advanced glycation end products toxicity is related to prognosis of chronic hemodialysis patients. Kalousova M, etal., Kidney Blood Press Res. 2010;33(1):30-6. doi: 10.1159/000285845. Epub 2010 Feb 23.
4. Contents of D-lactate and its related metabolites as well as enzyme activities in the liver, muscle and blood plasma of aging rats. Kawase M, etal., Mech Ageing Dev. 1995 Sep 29;84(1):55-63.
5. Changes in concentrations of methylglyoxal, D-lactate and glyoxalase activities in liver and plasma of rats fed a 3'-methyl-4-dimethylaminoazobenzene-rich diet. Kawase M, etal., Res Exp Med (Berl). 1996;196(4):251-9.
6. Glyoxalase I overexpression ameliorates renal ischemia-reperfusion injury in rats. Kumagai T, etal., Am J Physiol Renal Physiol. 2009 Apr;296(4):F912-21. doi: 10.1152/ajprenal.90575.2008. Epub 2009 Feb 11.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Case-control and family-based association studies of candidate genes in autistic disorder and its endophenotypes: TPH2 and GLO1. Sacco R, etal., BMC Med Genet. 2007 Mar 8;8:11.
14. Maillard reactions in lens proteins: methylglyoxal-mediated modifications in the rat lens. Shamsi FA, etal., Exp Eye Res. 2000 Mar;70(3):369-80.
15. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
16. Association of two glyoxalase I gene polymorphisms with nephropathy and retinopathy in Type 2 diabetes. Wu JC, etal., J Endocrinol Invest. 2011 Nov;34(10):e343-8. doi: 10.3275/7856. Epub 2011 Jul 7.
Additional References at PubMed
PMID:566476   PMID:910130   PMID:1914521   PMID:7323947   PMID:7333654   PMID:7444718   PMID:9705294   PMID:10807791   PMID:11489834   PMID:15489334   PMID:17670746   PMID:18695250  
PMID:19056867   PMID:22171037   PMID:22859292   PMID:22893478   PMID:23376485   PMID:23533145   PMID:23717693   PMID:24498315   PMID:27296676   PMID:28231326   PMID:28241483   PMID:31420161  
PMID:31505169  


Genomics

Comparative Map Data
Glo1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8208,665,061 - 8,683,095 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl208,665,061 - 8,683,191 (-)EnsemblGRCr8
mRatBN7.2208,663,617 - 8,681,661 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl208,662,801 - 8,681,649 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx209,355,240 - 9,374,295 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0208,716,413 - 8,735,468 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0209,192,465 - 9,211,480 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0209,273,589 - 9,291,608 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl209,273,594 - 9,291,610 (-)Ensemblrn6Rnor6.0
Rnor_5.02011,461,655 - 11,479,690 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4208,900,984 - 8,919,001 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2010,191,302 - 10,209,289 (-)NCBICelera
RGSC_v3.1208,901,210 - 8,919,228 (-)NCBI
Cytogenetic Map20p12NCBI
GLO1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38638,675,925 - 38,703,145 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl638,675,925 - 38,703,145 (-)Ensemblhg38GRCh38
GRCh37638,643,701 - 38,670,921 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36638,751,679 - 38,778,930 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34638,751,697 - 38,778,895NCBI
Celera640,197,188 - 40,224,451 (-)NCBICelera
Cytogenetic Map6p21.2NCBI
HuRef638,361,494 - 38,388,795 (-)NCBIHuRef
CHM1_1638,645,758 - 38,673,043 (-)NCBICHM1_1
T2T-CHM13v2.0638,500,476 - 38,527,717 (-)NCBIT2T-CHM13v2.0
Glo1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391730,811,835 - 30,831,633 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1730,803,910 - 30,845,845 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381730,592,861 - 30,612,659 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1730,584,936 - 30,626,871 (-)Ensemblmm10GRCm38
MGSCv371730,729,806 - 30,749,604 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361730,319,873 - 30,339,606 (-)NCBIMGSCv36mm8
MGSCv361729,807,695 - 29,826,707 (-)NCBIMGSCv36mm8
Celera235,035,059 - 35,036,311 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1715.69NCBI
Glo1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554374,728,709 - 4,749,834 (+)Ensembl
ChiLan1.0NW_0049554374,728,709 - 4,749,834 (+)NCBIChiLan1.0ChiLan1.0
GLO1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2553,155,138 - 53,182,369 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1649,025,050 - 49,052,295 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0638,247,881 - 38,275,098 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1639,434,750 - 39,461,971 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl639,434,746 - 39,461,971 (-)EnsemblpanPan2panpan1.1
GLO1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1127,584,141 - 7,609,615 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl127,585,531 - 7,609,550 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha127,600,020 - 7,625,500 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0128,048,947 - 8,078,703 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl128,049,266 - 8,078,652 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1127,587,392 - 7,612,855 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0127,664,812 - 7,690,339 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0127,770,412 - 7,795,893 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Glo1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494643,029,925 - 43,049,491 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647620,910,629 - 20,930,295 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647620,910,696 - 20,928,583 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GLO1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl734,157,535 - 34,183,528 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1734,156,194 - 34,183,560 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2739,244,145 - 39,271,510 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GLO1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11733,446,134 - 33,472,240 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1733,446,145 - 33,473,699 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604438,633,681 - 38,659,829 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Glo1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475419,533,719 - 19,551,794 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475419,533,730 - 19,549,483 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Glo1
150 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:46
Count of miRNA genes:37
Interacting mature miRNAs:44
Transcripts:ENSRNOT00000000650
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)20418947649189476Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804392029865039Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124164241Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20127341128Rat
1598870Bp289Blood pressure QTL 2892.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)20821635953216359Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129193376Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129193376Rat
1581577Pur15Proteinuria QTL 154.380.0002urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)20804392015089182Rat
1598858Cm61Cardiac mass QTL 613.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)20821635953216359Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578510Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20126925056Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20133724594Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126128279Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600300Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20153308346533083Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20134066551Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362632310078622Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129193376Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2036263239244918Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129193376Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129193376Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20114100378Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600300Rat

Markers in Region
RH133855  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2208,663,915 - 8,664,100 (+)MAPPERmRatBN7.2
Rnor_6.0209,273,888 - 9,274,072NCBIRnor6.0
Rnor_5.02011,461,954 - 11,462,138UniSTSRnor5.0
RGSC_v3.4208,901,283 - 8,901,467UniSTSRGSC3.4
Celera2010,191,601 - 10,191,785UniSTS
RH 3.4 Map20112.4UniSTS
Cytogenetic Map20p12UniSTS
RH138820  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2208,678,463 - 8,678,655 (+)MAPPERmRatBN7.2
Rnor_6.0209,288,427 - 9,288,618NCBIRnor6.0
Rnor_5.02011,476,493 - 11,476,684UniSTSRnor5.0
RGSC_v3.4208,915,821 - 8,916,012UniSTSRGSC3.4
Celera2010,206,109 - 10,206,300UniSTS
RH 3.4 Map20110.9UniSTS
Cytogenetic Map20p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000000650   ⟹   ENSRNOP00000000650
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl208,665,061 - 8,683,191 (-)Ensembl
mRatBN7.2 Ensembl208,662,801 - 8,681,649 (-)Ensembl
Rnor_6.0 Ensembl209,273,594 - 9,291,610 (-)Ensembl
RefSeq Acc Id: NM_207594   ⟹   NP_997477
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8208,665,061 - 8,683,080 (-)NCBI
mRatBN7.2208,663,617 - 8,681,645 (-)NCBI
Rnor_6.0209,273,589 - 9,291,608 (-)NCBI
Rnor_5.02011,461,655 - 11,479,690 (-)NCBI
RGSC_v3.4208,900,984 - 8,919,001 (-)RGD
Celera2010,191,302 - 10,209,289 (-)RGD
Sequence:
RefSeq Acc Id: XR_010060645
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8208,668,349 - 8,683,095 (-)NCBI
Protein Sequences
Protein RefSeqs NP_997477 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH61570 (Get FASTA)   NCBI Sequence Viewer  
  EDL96989 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000000650.4
GenBank Protein Q6P7Q4 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_997477   ⟸   NM_207594
- UniProtKB: Q6P7Q4 (UniProtKB/Swiss-Prot),   A6JJX3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000000650   ⟸   ENSRNOT00000000650
Protein Domains
VOC

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6P7Q4-F1-model_v2 AlphaFold Q6P7Q4 1-184 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701467
Promoter ID:EPDNEW_R11991
Type:initiation region
Name:Glo1_1
Description:glyoxalase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0209,291,585 - 9,291,645EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2702 AgrOrtholog
BioCyc Gene G2FUF-4345 BioCyc
Ensembl Genes ENSRNOG00000000541 Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000000650.7 UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.180.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6918143 IMAGE-MGC_LOAD
InterPro Glyas_Bleomycin-R_OHBP_Dase UniProtKB/Swiss-Prot
  Glyas_Fos-R_dOase_dom UniProtKB/Swiss-Prot
  Glyoxalase_1 UniProtKB/Swiss-Prot
  Glyoxalase_1_CS UniProtKB/Swiss-Prot
  VOC UniProtKB/Swiss-Prot
KEGG Report rno:294320 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72954 IMAGE-MGC_LOAD
NCBI Gene Glo1 ENTREZGENE
PANTHER LACTOYLGLUTATHIONE LYASE UniProtKB/Swiss-Prot
  LACTOYLGLUTATHIONE LYASE GLYOXALASE I UniProtKB/Swiss-Prot
Pfam Glyoxalase UniProtKB/Swiss-Prot
PhenoGen Glo1 PhenoGen
PROSITE GLYOXALASE_I_1 UniProtKB/Swiss-Prot
  GLYOXALASE_I_2 UniProtKB/Swiss-Prot
  VOC UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000000541 RatGTEx
Superfamily-SCOP SSF54593 UniProtKB/Swiss-Prot
UniProt A6JJX3 ENTREZGENE, UniProtKB/TrEMBL
  LGUL_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-15 Glo1  glyoxalase 1  Glo1  glyoxylase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Glo1  Glyoxalase 1      Symbol and Name status set to approved 70586 APPROVED