Gdf15 (growth differentiation factor 15) - Rat Genome Database

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Gene: Gdf15 (growth differentiation factor 15) Rattus norvegicus
Analyze
Symbol: Gdf15
Name: growth differentiation factor 15
RGD ID: 2674
Description: Enables protein homodimerization activity. Predicted to be involved in several processes, including GDF15-GFRAL signaling pathway; reduction of food intake in response to dietary excess; and regulation of signal transduction. Predicted to act upstream of or within positive regulation of myoblast fusion. Located in extracellular region. Orthologous to human GDF15 (growth differentiation factor 15); INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GDF-15; growth/differentiation factor 15
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81618,838,436 - 18,842,022 (+)NCBIGRCr8
mRatBN7.21618,804,457 - 18,808,043 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1618,805,239 - 18,808,055 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1618,847,005 - 18,849,564 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01619,979,943 - 19,982,528 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01618,899,963 - 18,902,522 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01620,555,395 - 20,557,978 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,555,395 - 20,557,978 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01620,411,167 - 20,413,750 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41619,310,882 - 19,313,465 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11619,310,851 - 19,313,463 (+)NCBI
Celera1618,997,242 - 18,999,829 (+)NCBICelera
Cytogenetic Map16p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-taxifolin  (ISO)
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-colchicine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dichloroindophenol  (ISO)
2-acetamidofluorene  (ISO)
2-butoxyethanol  (ISO)
2-nitrofluorene  (EXP)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3'-diindolylmethane  (ISO)
3,4-dichloroaniline  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-Hydroxybenzophenone  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-bromo-2'-deoxyuridine  (ISO)
5-fluorouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (ISO)
[6]-Shogaol  (ISO)
aceclofenac  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (EXP)
acrylamide  (EXP,ISO)
actinomycin D  (ISO)
adefovir pivoxil  (ISO)
adenine  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
amphibole asbestos  (ISO)
amphotericin B  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimycin A  (ISO)
arecoline  (ISO)
aristolochic acid A  (EXP,ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
Aurin  (ISO)
azathioprine  (ISO)
azoxystrobin  (EXP,ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[ghi]perylene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bortezomib  (EXP,ISO)
bromoacetate  (ISO)
bromobenzene  (EXP)
buta-1,3-diene  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
cefaloridine  (EXP)
celastrol  (ISO)
celecoxib  (ISO)
chlordecone  (ISO)
chloroacetaldehyde  (ISO)
chloropicrin  (ISO)
chloroprene  (ISO)
chlorpromazine  (EXP)
chlorpyrifos  (EXP)
chromium(6+)  (ISO)
chrysene  (ISO)
cidofovir anhydrous  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
clofibrate  (ISO)
clothianidin  (ISO)
clozapine  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
corosolic acid  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cryptolepine  (ISO)
CU-O LINKAGE  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
daunorubicin  (ISO)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
diallyl disulfide  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
dichromium trioxide  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
Didecyldimethylammonium  (ISO)
dieldrin  (ISO)
diethyl maleate  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (EXP)
dihydroxyacetone  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethylarsinic acid  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (EXP,ISO)
diquat  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
divanadium pentaoxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP,ISO)
Enterolactone  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
erlotinib hydrochloride  (ISO)
esketamine  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
fenamidone  (ISO)
fenofibrate  (EXP,ISO)
fenpyroximate  (ISO)
flurbiprofen  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP,ISO)
gedunin  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (EXP)
gingerol  (ISO)
glyphosate  (EXP)
graphene oxide  (ISO)
graphite  (EXP)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hydroxyurea  (ISO)
ibuprofen  (ISO)
ifosfamide  (ISO)
imidacloprid  (EXP)
imidazopyrazole  (ISO)
indole-3-methanol  (ISO)
indometacin  (ISO)
inulin  (ISO)
irinotecan  (ISO)
iron dichloride  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
jaspamide  (ISO)
Lasiocarpine  (ISO)
latrunculin B  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
lucanthone  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
metacetamol  (ISO)
metformin  (EXP)
methamphetamine  (EXP,ISO)
methapyrilene  (EXP)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
mitomycin C  (ISO)
Mitotane  (ISO)
mitoxantrone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N(4)-hydroxycytidine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methylformamide  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
N-Nitrosopyrrolidine  (ISO)
naphthalene  (EXP,ISO)
nevirapine  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
NS-398  (ISO)
Nutlin-3  (ISO)
O-methyleugenol  (ISO)
Octicizer  (ISO)
octreotide  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pentanal  (ISO)
perfluorodecanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
perfluoroundecanoic acid  (ISO)
phenobarbital  (ISO)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
phloroglucinol  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosgene  (ISO)
picoxystrobin  (ISO)
pifithrin-alpha hydrobromide  (ISO)
pinosylvin  (ISO)
pioglitazone  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
platycodin D  (ISO)
potassium dichromate  (ISO)
progesterone  (EXP,ISO)
propanal  (ISO)
prostaglandin J2  (ISO)
pterostilbene  (ISO)
pyrimidifen  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
Ro 31-8220  (ISO)
rotenone  (EXP,ISO)
rottlerin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
Securinine  (ISO)
serpentine asbestos  (ISO)
silibinin  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulindac  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thallium  (EXP)
thallium sulfate  (EXP)
thapsigargin  (ISO)
theophylline  (ISO)
thiabendazole  (EXP)
thifluzamide  (ISO)
thioacetamide  (EXP)
thiostrepton  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trans-pinosylvin  (ISO)
tributyl phosphate  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
troglitazone  (ISO)
Tungsten carbide  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vincristine  (ISO)
wortmannin  (ISO)
zinc atom  (EXP,ISO)
zinc oxide  (EXP)
zinc pyrithione  (ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO,ISS)
extracellular region  (IDA,IEA,ISO,ISS)
extracellular space  (IBA,IEA,ISO,ISS)
Golgi apparatus  (IEA,ISO)
nucleus  (IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Characterization of the rat, mouse, and human genes of growth/differentiation factor-15/macrophage inhibiting cytokine-1 (GDF-15/MIC-1). Bottner M, etal., Gene 1999 Sep 3;237(1):105-11.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Hepcidin and GDF15 in anemia of multiple myeloma. Mei S, etal., Int J Hematol. 2014 Sep;100(3):266-73. doi: 10.1007/s12185-014-1626-7. Epub 2014 Jul 23.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
10. Long-acting MIC-1/GDF15 molecules to treat obesity: Evidence from mice to monkeys. Xiong Y, etal., Sci Transl Med. 2017 Oct 18;9(412). pii: 9/412/eaan8732. doi: 10.1126/scitranslmed.aan8732.
Additional References at PubMed
PMID:19103603   PMID:23376485   PMID:23435960   PMID:23468844   PMID:23533145   PMID:23844157   PMID:23986522   PMID:25551924   PMID:25893289   PMID:26647773   PMID:26811051   PMID:27566082  
PMID:28025863   PMID:28572090   PMID:28846097   PMID:28846098   PMID:28846099   PMID:28953886   PMID:30355197   PMID:30554141   PMID:31852204   PMID:34019665   PMID:36336027   PMID:37584611  


Genomics

Comparative Map Data
Gdf15
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81618,838,436 - 18,842,022 (+)NCBIGRCr8
mRatBN7.21618,804,457 - 18,808,043 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1618,805,239 - 18,808,055 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1618,847,005 - 18,849,564 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01619,979,943 - 19,982,528 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01618,899,963 - 18,902,522 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01620,555,395 - 20,557,978 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,555,395 - 20,557,978 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01620,411,167 - 20,413,750 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41619,310,882 - 19,313,465 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11619,310,851 - 19,313,463 (+)NCBI
Celera1618,997,242 - 18,999,829 (+)NCBICelera
Cytogenetic Map16p14NCBI
GDF15
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381918,386,158 - 18,389,176 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1918,374,731 - 18,389,176 (+)EnsemblGRCh38hg38GRCh38
GRCh371918,496,968 - 18,499,986 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361918,357,968 - 18,360,986 (+)NCBINCBI36Build 36hg18NCBI36
Build 341918,357,984 - 18,360,986NCBI
Celera1918,398,797 - 18,401,815 (+)NCBICelera
Cytogenetic Map19p13.11NCBI
HuRef1918,062,378 - 18,063,268 (+)NCBIHuRef
CHM1_11918,497,209 - 18,500,231 (+)NCBICHM1_1
T2T-CHM13v2.01918,515,920 - 18,523,324 (+)NCBIT2T-CHM13v2.0
Gdf15
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39871,082,043 - 71,085,106 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl871,082,043 - 71,085,106 (-)EnsemblGRCm39 Ensembl
GRCm38870,629,393 - 70,632,470 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl870,629,393 - 70,632,456 (-)EnsemblGRCm38mm10GRCm38
MGSCv37873,153,293 - 73,155,534 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36873,558,382 - 73,561,082 (-)NCBIMGSCv36mm8
Celera873,186,175 - 73,188,416 (-)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.15NCBI
Gdf15
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555243,123,760 - 3,125,621 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555243,123,513 - 3,125,642 (-)NCBIChiLan1.0ChiLan1.0
GDF15
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22023,235,317 - 23,249,754 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11922,255,036 - 22,258,089 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01917,864,840 - 17,867,883 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11918,835,216 - 18,838,470 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1918,835,216 - 18,838,470 (+)Ensemblpanpan1.1panPan2
GDF15
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12044,633,131 - 44,636,842 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2044,634,588 - 44,636,821 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2044,547,490 - 44,551,239 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02045,119,086 - 45,122,834 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2045,120,542 - 45,122,775 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12044,356,357 - 44,360,107 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02044,766,491 - 44,770,241 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02045,041,907 - 45,045,657 (-)NCBIUU_Cfam_GSD_1.0
Gdf15
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118203,305,463 - 203,310,650 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365962,854,841 - 2,857,111 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365962,854,620 - 2,857,018 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GDF15
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl259,408,904 - 59,411,358 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1259,409,035 - 59,411,356 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
GDF15
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1616,853,397 - 16,861,924 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl616,852,971 - 16,861,964 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660742,479,299 - 2,485,699 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gdf15
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249081,634,174 - 1,636,242 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249081,633,927 - 1,636,242 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gdf15
18 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:115
Count of miRNA genes:101
Interacting mature miRNAs:106
Transcripts:ENSRNOT00000026652
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
631517Scl9Serum cholesterol level QTL 93.3blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)161572643321034895Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338015021361552Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat

Markers in Region
UniSTS:496654  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21618,805,196 - 18,805,308 (+)MAPPERmRatBN7.2
Rnor_6.01620,555,280 - 20,555,391NCBIRnor6.0
Rnor_5.01620,411,052 - 20,411,163UniSTSRnor5.0
RGSC_v3.41619,310,767 - 19,310,878UniSTSRGSC3.4
Celera1618,997,127 - 18,997,238UniSTS
Cytogenetic Map16p14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 10 47 110 91 90 59 25 59 6 214 94 90 45 58 31

Sequence


Ensembl Acc Id: ENSRNOT00000026652   ⟹   ENSRNOP00000026652
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1618,805,239 - 18,808,055 (+)Ensembl
Rnor_6.0 Ensembl1620,555,395 - 20,557,978 (+)Ensembl
RefSeq Acc Id: NM_001411583   ⟹   NP_001398512
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,839,265 - 18,842,022 (+)NCBI
mRatBN7.21618,805,286 - 18,808,043 (+)NCBI
RefSeq Acc Id: NM_019216   ⟹   NP_062089
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,838,436 - 18,842,022 (+)NCBI
mRatBN7.21618,804,457 - 18,808,043 (+)NCBI
Rnor_6.01620,555,395 - 20,557,978 (+)NCBI
Rnor_5.01620,411,167 - 20,413,750 (+)NCBI
RGSC_v3.41619,310,882 - 19,313,465 (+)RGD
Celera1618,997,242 - 18,999,829 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001398512 (Get FASTA)   NCBI Sequence Viewer  
  NP_062089 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA09891 (Get FASTA)   NCBI Sequence Viewer  
  EDL90718 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000026652
  ENSRNOP00000026652.1
GenBank Protein Q9Z0J6 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_062089   ⟸   NM_019216
- Peptide Label: precursor
- UniProtKB: Q9Z0J6 (UniProtKB/Swiss-Prot),   G3V8K5 (UniProtKB/TrEMBL),   A6KA19 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000026652   ⟸   ENSRNOT00000026652
RefSeq Acc Id: NP_001398512   ⟸   NM_001411583
- Peptide Label: precursor
- UniProtKB: Q9Z0J6 (UniProtKB/Swiss-Prot),   G3V8K5 (UniProtKB/TrEMBL),   A6KA19 (UniProtKB/TrEMBL)
Protein Domains
TGF-beta family profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z0J6-F1-model_v2 AlphaFold Q9Z0J6 1-303 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700022
Promoter ID:EPDNEW_R10545
Type:single initiation site
Name:Gdf15_1
Description:growth differentiation factor 15
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01620,555,375 - 20,555,435EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2674 AgrOrtholog
BioCyc Gene G2FUF-11794 BioCyc
Ensembl Genes ENSRNOG00000019661 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026652 ENTREZGENE
  ENSRNOT00000026652.4 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-b_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-beta-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29455 UniProtKB/Swiss-Prot
NCBI Gene 29455 ENTREZGENE
PANTHER GROWTH/DIFFERENTIATION FACTOR 15 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11848 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TGF_beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gdf15 PhenoGen
PROSITE TGF_BETA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019661 RatGTEx
SMART TGFB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC237906
UniProt A6KA19 ENTREZGENE, UniProtKB/TrEMBL
  G3V8K5 ENTREZGENE, UniProtKB/TrEMBL
  GDF15_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Gdf15  growth differentiation factor 15      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains a seven conserved carboxy-terminal cysteine residues that form the cystine knot 69844
gene_expression expressed in all tissues 69844
gene_product member of the TGF-beta superfamily 69844
gene_transcript promoter region contains multiple regulatory elements, including a TATA-like sequence as well as several SP1, AP-1 and AP-2 sites 69844