Fshb (follicle stimulating hormone subunit beta) - Rat Genome Database

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Gene: Fshb (follicle stimulating hormone subunit beta) Rattus norvegicus
Analyze
Symbol: Fshb
Name: follicle stimulating hormone subunit beta
RGD ID: 2630
Description: Predicted to enable follicle-stimulating hormone activity. Predicted to be involved in several processes, including follicle-stimulating hormone signaling pathway; positive regulation of steroid biosynthetic process; and transforming growth factor beta receptor signaling pathway. Predicted to act upstream of or within several processes, including gonad development; positive regulation of bone resorption; and regulation of osteoclast differentiation. Predicted to be part of follicle-stimulating hormone complex. Predicted to be active in cytoplasm and extracellular space. Human ortholog(s) of this gene implicated in amenorrhea and hypogonadotropic hypogonadism 24 without anosmia. Orthologous to human FSHB (follicle stimulating hormone subunit beta); PARTICIPATES IN follicle-stimulating hormone signaling pathway; gonadotropin-releasing hormone signaling pathway; INTERACTS WITH (+)-artemisinin; (+)-pilocarpine; (+)-taxifolin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: follicle - stimulating hormone subunit beta; follicle stimulating hormone beta; follicle stimulating hormone beta subunit; follicle stimulating hormone, beta polypeptide; follicle-stimulating hormone beta subunit; follicle-stimulating hormone beta-subunit; follicle-stimulating hormone subunit beta; follitropin beta chain; follitropin subunit beta; FSH-B; FSH-beta
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83114,003,262 - 114,007,072 (-)NCBIGRCr8
GRCr8 Ensembl3114,003,262 - 114,007,072 (-)EnsemblGRCr8 Ensembl
mRatBN7.2393,548,560 - 93,552,370 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl393,548,560 - 93,552,370 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx397,074,668 - 97,078,475 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03105,673,601 - 105,677,408 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03103,471,309 - 103,475,119 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0398,088,321 - 98,092,131 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl398,088,324 - 98,092,131 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03104,700,141 - 104,703,954 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4392,569,344 - 92,571,254 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera392,595,527 - 92,599,337 (-)NCBICelera
RGSC_v3.1392,465,296 - 92,467,695 (-)NCBI
Cytogenetic Map3q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinin  (EXP)
(+)-pilocarpine  (EXP)
(+)-taxifolin  (EXP)
(R)-carnitine  (EXP)
(R)-lipoic acid  (EXP)
(S)-nicotine  (EXP)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-Dibromo-3-chloropropane  (EXP)
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,5-trichlorophenol  (ISO)
2,4-Dihydroxybenzophenone  (ISO)
2-hydroxyestrone  (ISO)
2-tert-butylhydroquinone  (EXP)
3',5'-cyclic AMP  (EXP,ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
3,4-dihydroxybenzoic acid  (EXP)
3-[(4-anilinophenyl)diazenyl]benzene-1-sulfonic acid  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
4'-epidoxorubicin  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-Hydroxybenzophenone  (ISO)
4-nitrophenyl beta-D-xyloside  (EXP)
4-nonylphenol  (EXP)
4-vinylcyclohexene dioxide  (EXP)
5-formyltetrahydrofolic acid  (EXP)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (EXP)
acetaldehyde  (ISO)
acetate ester  (EXP)
acrylamide  (EXP)
adenosine  (ISO)
AICA ribonucleotide  (EXP)
alcohol  (ISO)
all-trans-retinoic acid  (EXP,ISO)
allethrin  (EXP)
aminoglutethimide  (ISO)
ammonium chloride  (EXP)
anastrozole  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
apocynin  (EXP)
arecoline  (EXP)
Aroclor 1254  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
aspartame  (ISO)
atrazine  (EXP,ISO)
baclofen  (EXP)
benzo[a]pyrene  (EXP,ISO)
beta-naphthoflavone  (EXP)
betamethasone  (EXP)
bezafibrate  (ISO)
bicalutamide  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (EXP,ISO)
Bisphenol B  (EXP)
bisphenol F  (EXP)
bleomycin A2  (ISO)
bromocriptine  (ISO)
buserelin  (ISO)
busulfan  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
Butylparaben  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calciol  (EXP)
carbaryl  (ISO)
carbendazim  (EXP)
carboplatin  (EXP)
carvacrol  (EXP)
celecoxib  (EXP)
cetrorelix  (EXP,ISO)
CGP 52608  (ISO)
chlorogenic acid  (ISO)
chlorpyrifos  (EXP,ISO)
chromium(6+)  (EXP)
chrysin  (EXP)
cilostazol  (EXP)
cimetidine  (ISO)
cisplatin  (EXP)
clomiphene  (ISO)
colforsin daropate hydrochloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
corticosterone  (ISO)
crizotinib  (ISO)
CU-O LINKAGE  (EXP)
curcumin  (EXP)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP)
cyhalothrin  (EXP)
cypermethrin  (EXP,ISO)
cyproterone acetate  (ISO)
danazol  (EXP)
DDE  (ISO)
DDT  (EXP,ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (EXP,ISO)
Dicyclohexyl phthalate  (EXP)
dienogest  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (EXP,ISO)
difenoconazole  (EXP)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethoate  (EXP)
dioxygen  (EXP)
disodium selenite  (EXP)
disulfiram  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (EXP)
emamectin benzoate  (EXP)
erythrosin B  (EXP)
Estradiol 17beta-cyclopentylpropionate  (EXP)
ethanol  (EXP)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
fenarimol  (EXP)
fenitrothion  (EXP)
fenvalerate  (EXP)
Finrozole  (ISO)
fisetin  (EXP)
flufenamic acid  (EXP)
flutamide  (EXP,ISO)
fluvastatin  (EXP)
folic acid  (ISO)
formaldehyde  (EXP)
formestane  (EXP)
fructose  (EXP)
fulvestrant  (EXP,ISO)
furan  (EXP)
galaxolide  (EXP)
gallic acid  (EXP,ISO)
gamma-hexachlorocyclohexane  (EXP)
genistein  (EXP)
gingerol  (ISO)
ginsenoside Rg1  (ISO)
glutathione  (EXP)
glyphosate  (EXP,ISO)
Goserelin  (ISO)
GW 1929  (ISO)
herbicide  (EXP)
hexachlorobenzene  (EXP)
hyaluronic acid  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
imidacloprid  (EXP)
indometacin  (EXP)
iodoacetic acid  (ISO)
iprodione  (EXP)
isoprenaline  (EXP)
ketamine  (EXP)
ketoconazole  (ISO)
L-ascorbic acid  (EXP)
lead diacetate  (EXP)
lead(0)  (ISO)
letrozole  (EXP,ISO)
levonorgestrel  (ISO)
lipoic acid  (EXP)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
lumefantrine  (EXP)
LY294002  (ISO)
manganese(II) chloride  (EXP)
medroxyprogesterone  (ISO)
medroxyprogesterone acetate  (ISO)
melatonin  (EXP)
menadione  (EXP)
mestranol  (ISO)
metformin  (EXP)
methomyl  (EXP)
methotrexate  (EXP)
methoxyacetic acid  (EXP)
methoxychlor  (EXP,ISO)
methylparaben  (EXP)
metolachlor  (EXP)
mifepristone  (EXP)
mirtazapine  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (ISO)
morin  (EXP)
muscimol  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP,ISO)
N-acetyl-L-cysteine  (EXP)
N-methyl-N-nitrosourea  (EXP)
naltrexone  (ISO)
naringin  (EXP)
nickel atom  (EXP)
nicotine  (EXP)
nimodipine  (ISO)
nobiletin  (EXP)
Nonylphenol  (EXP)
octreotide  (EXP,ISO)
oxybenzone  (ISO)
ozone  (ISO)
paraquat  (EXP)
pasireotide  (EXP,ISO)
pentobarbital  (EXP)
perfluorododecanoic acid  (EXP)
perfluoroheptanoic acid  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
perfluoroundecanoic acid  (EXP)
perphenazine  (EXP)
phenylhydrazine  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
pinostrobin  (EXP)
potassium dichromate  (EXP)
pregnenolone  (ISO)
procymidone  (EXP)
progesterone  (EXP,ISO)
promegestone  (ISO)
propylparaben  (EXP,ISO)
pyrethrins  (EXP)
pyrrolidine dithiocarbamate  (EXP)
quercetin  (EXP,ISO)
resveratrol  (EXP,ISO)
risperidone  (ISO)
rolipram  (EXP,ISO)
SB 203580  (EXP)
SB 431542  (EXP,ISO)
selenium atom  (EXP)
sildenafil citrate  (ISO)
sirolimus  (EXP)
sodium arsenite  (EXP,ISO)
sodium benzoate  (EXP)
sodium chlorate  (EXP)
sodium fluoride  (EXP)
sophoraflavanone B  (EXP)
spironolactone  (EXP)
streptozocin  (EXP,ISO)
succimer  (EXP)
sulfasalazine  (ISO)
T-2 toxin  (EXP,ISO)
tamoxifen  (EXP,ISO)
tartrazine  (EXP)
taurine  (EXP)
testosterone  (EXP,ISO)
testosterone enanthate  (EXP,ISO)
Testosterone propionate  (EXP)
Tetrachlorobisphenol A  (EXP)
thimerosal  (ISO)
thymol  (EXP)
thymol sulfate(1-)  (EXP)
thymoquinone  (ISO)
titanium dioxide  (EXP)
tributylstannane  (EXP)
trichlorfon  (ISO)
triciribine  (ISO)
triclosan  (EXP)
trilostane  (ISO)
tyrphostin AG 1478  (EXP,ISO)
uranium atom  (EXP)
valsartan  (EXP)
vanadium atom  (EXP)
vanadium(0)  (EXP)
vinclozolin  (EXP)
vitamin E  (EXP)
vitexin  (ISO)
wortmannin  (EXP)
zearalenone  (EXP)
ziram  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISO)
extracellular region  (IEA)
extracellular space  (IBA,IEA,ISO,ISS)
follicle-stimulating hormone complex  (IEA,ISO,ISS,TAS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Regulation of gonadotropin subunit gene transcription by gonadotropin-releasing hormone: measurement of primary transcript ribonucleic acids by quantitative reverse transcription-polymerase chain reaction assays. Dalkin AC, etal., Endocrinology 2001 Jan;142(1):139-46.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Isolation and characterization of the gene encoding the beta-subunit of rat follicle-stimulating hormone. Gharib SD, etal., DNA 1989 Jun;8(5):339-49.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Primary amenorrhoea and infertility due to a mutation in the beta-subunit of follicle-stimulating hormone. Matthews CH, etal., Nat Genet. 1993 Sep;5(1):83-6.
6. Molecular cloning and nucleotide sequence analysis of complementary deoxyribonucleic acid for the beta-subunit of rat follicle stimulating hormone. Maurer RA Mol Endocrinol 1987 Oct;1(10):717-23.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Endocrine cells of the adenohypophysis in severe acute respiratory syndrome (SARS). Wei L, etal., Biochem Cell Biol. 2010 Aug;88(4):723-30. doi: 10.1139/O10-022.
16. Pituitary homeobox 1 activates the rat FSHbeta (rFSHbeta) gene through both direct and indirect interactions with the rFSHbeta gene promoter. Zakaria MM, etal., Mol Endocrinol 2002 Aug;16(8):1840-52.
Additional References at PubMed
PMID:2494176   PMID:9020850   PMID:11416011   PMID:11514332   PMID:12477932   PMID:12554780   PMID:12646491   PMID:14512439   PMID:14557487   PMID:14602737   PMID:14982927   PMID:15375186  
PMID:15761025   PMID:16339198   PMID:16630814   PMID:17405825   PMID:17674129   PMID:17932215   PMID:18022758   PMID:18160680   PMID:18206295   PMID:18248883   PMID:18363807   PMID:18550775  
PMID:18635654   PMID:19200975   PMID:19464343   PMID:20201104   PMID:21228211   PMID:22106407   PMID:22249524   PMID:22564408   PMID:23242526   PMID:23299500   PMID:23349233   PMID:23376485  
PMID:24692546   PMID:24739304   PMID:25635942   PMID:26853521   PMID:27030385   PMID:28402262   PMID:29534107  


Genomics

Comparative Map Data
Fshb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83114,003,262 - 114,007,072 (-)NCBIGRCr8
GRCr8 Ensembl3114,003,262 - 114,007,072 (-)EnsemblGRCr8 Ensembl
mRatBN7.2393,548,560 - 93,552,370 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl393,548,560 - 93,552,370 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx397,074,668 - 97,078,475 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03105,673,601 - 105,677,408 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03103,471,309 - 103,475,119 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0398,088,321 - 98,092,131 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl398,088,324 - 98,092,131 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03104,700,141 - 104,703,954 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4392,569,344 - 92,571,254 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera392,595,527 - 92,599,337 (-)NCBICelera
RGSC_v3.1392,465,296 - 92,467,695 (-)NCBI
Cytogenetic Map3q33NCBI
FSHB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381130,231,014 - 30,235,194 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1130,231,014 - 30,235,261 (+)EnsemblGRCh38hg38GRCh38
GRCh371130,252,561 - 30,256,741 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361130,209,139 - 30,213,400 (+)NCBINCBI36Build 36hg18NCBI36
Build 341130,210,025 - 30,211,923NCBI
Celera1130,398,958 - 30,403,219 (+)NCBICelera
Cytogenetic Map11p14.1NCBI
HuRef1129,945,298 - 29,949,559 (+)NCBIHuRef
CHM1_11130,251,554 - 30,255,815 (+)NCBICHM1_1
T2T-CHM13v2.01130,365,200 - 30,369,380 (+)NCBIT2T-CHM13v2.0
Fshb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392106,886,331 - 106,889,996 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2106,886,485 - 106,890,001 (-)EnsemblGRCm39 Ensembl
GRCm382107,055,986 - 107,059,651 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2107,056,140 - 107,059,656 (-)EnsemblGRCm38mm10GRCm38
MGSCv372106,896,297 - 106,899,808 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362106,856,979 - 106,860,490 (-)NCBIMGSCv36mm8
Celera2108,277,790 - 108,281,303 (-)NCBICelera
Cytogenetic Map2E3NCBI
cM Map256.02NCBI
Fshb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554768,795,351 - 8,797,244 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554768,795,354 - 8,797,244 (+)NCBIChiLan1.0ChiLan1.0
FSHB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2932,451,385 - 32,454,711 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11132,456,189 - 32,459,515 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01130,204,193 - 30,208,410 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11130,095,759 - 30,100,012 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1130,095,486 - 30,100,167 (+)Ensemblpanpan1.1panPan2
FSHB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12150,279,320 - 50,282,843 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2150,280,208 - 50,282,680 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2149,721,618 - 49,725,189 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02151,453,974 - 51,457,558 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2151,454,924 - 51,457,395 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12150,500,112 - 50,503,675 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02150,598,794 - 50,602,364 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02151,222,316 - 51,225,896 (+)NCBIUU_Cfam_GSD_1.0
Fshb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494734,269,268 - 34,273,598 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365337,395,206 - 7,397,266 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365337,395,206 - 7,397,266 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FSHB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl230,395,018 - 30,399,274 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1230,395,769 - 30,399,282 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2232,861,492 - 32,865,005 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap2p1.6-p1.2NCBI
FSHB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1134,943,544 - 34,947,796 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl134,943,568 - 34,946,863 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038132,120,141 - 132,124,387 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fshb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476619,329,371 - 19,331,267 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476619,328,730 - 19,332,385 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fshb
29 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:360
Count of miRNA genes:194
Interacting mature miRNAs:238
Transcripts:ENSRNOT00000006512
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358293Bw38Body weight QTL 3860.0000031body mass (VT:0001259)body weight (CMO:0000012)374364268119364268Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)396509147141509147Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)385062224136118980Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)385062224136118980Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)3104545086149545086Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)393829559138829559Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)3112250810157250810Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)3101255536134750886Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)396509147141509147Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)370311536115311536Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3110225882155225882Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)381541464126563126Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)390755164141509147Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)342158111124558371Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)342158111124558371Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3110634702155634702Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
3 13 25 10 8 1 21 20 19 1 17 8

Sequence


Ensembl Acc Id: ENSRNOT00000006512   ⟹   ENSRNOP00000006512
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3114,003,262 - 114,007,072 (-)Ensembl
mRatBN7.2 Ensembl393,548,560 - 93,552,370 (-)Ensembl
Rnor_6.0 Ensembl398,088,324 - 98,092,131 (-)Ensembl
RefSeq Acc Id: NM_001007597   ⟹   NP_001007598
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83114,003,262 - 114,007,072 (-)NCBI
mRatBN7.2393,548,560 - 93,552,370 (-)NCBI
Rnor_6.0398,088,321 - 98,092,131 (-)NCBI
Rnor_5.03104,700,141 - 104,703,954 (-)NCBI
RGSC_v3.4392,569,344 - 92,571,254 (-)RGD
Celera392,595,527 - 92,599,337 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001007598 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB60705 (Get FASTA)   NCBI Sequence Viewer  
  AAI68724 (Get FASTA)   NCBI Sequence Viewer  
  BAA00455 (Get FASTA)   NCBI Sequence Viewer  
  CCP37929 (Get FASTA)   NCBI Sequence Viewer  
  EDL79746 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000006512
  ENSRNOP00000006512.4
GenBank Protein P18427 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001007598   ⟸   NM_001007597
- Peptide Label: precursor
- UniProtKB: P18427 (UniProtKB/Swiss-Prot),   B5DEM1 (UniProtKB/TrEMBL),   A6HNZ5 (UniProtKB/TrEMBL),   A0A0F7RQH5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000006512   ⟸   ENSRNOT00000006512
Protein Domains
Glycoprotein hormone subunit beta

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P18427-F1-model_v2 AlphaFold P18427 1-130 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:6850002
Promoter ID:EP30072
Type:single initiation site
Name:RN_FSHB
Description:Follicle stimulating hormone-beta, FSHB gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Notes:homology_group=Homology group 180; Mammalian follicle stimulating hormone
Experiment Methods:Sequencing of a full-length cDNA; Primer extension
Regulation:pituitary; (induced by or strongly expressed in) GnRH
Position:
Rat AssemblyChrPosition (strand)Source
RGSC_v3.4392,571,953 - 92,572,013EPD

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2630 AgrOrtholog
BioCyc Gene G2FUF-48502 BioCyc
Ensembl Genes ENSRNOG00000004898 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000006512 ENTREZGENE
  ENSRNOT00000006512.6 UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot
  Glyco_hormone_CN UniProtKB/Swiss-Prot
  Gonadotropin_bsu UniProtKB/Swiss-Prot
  Gonadotropin_bsu_CS UniProtKB/Swiss-Prot
KEGG Report rno:25447 UniProtKB/Swiss-Prot
NCBI Gene 25447 ENTREZGENE
PANTHER FOLLITROPIN SUBUNIT BETA UniProtKB/Swiss-Prot
  PTHR11515 UniProtKB/Swiss-Prot
Pfam Cys_knot UniProtKB/Swiss-Prot
PhenoGen Fshb PhenoGen
PROSITE GLYCO_HORMONE_BETA_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000004898 RatGTEx
SMART GHB UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot
UniProt A0A0F7RQH5 ENTREZGENE, UniProtKB/TrEMBL
  A6HNZ5 ENTREZGENE, UniProtKB/TrEMBL
  B5DEM1 ENTREZGENE
  FSHB_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-07 Fshb  follicle stimulating hormone subunit beta  Fshb  follicle stimulating hormone beta subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-01-20 Fshb  follicle stimulating hormone beta subunit  Fshb  follicle stimulating hormone, beta polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Fshb  follicle stimulating hormone, beta polypeptide  Fshb  follicle stimulating hormone beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-01   follicle stimulating hormone beta  Fshb  follicle-stimulating hormone subunit beta  Name updated 1299863 APPROVED
2002-06-10 Fshb  follicle - stimulating hormone subunit beta      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expressed at high levels in pituitary 728523
gene_physical_interaction protein results from heterodimer with alpha subunit 728523
gene_process functions in reproduction 61523
gene_regulation estrogen downregulates mRNA in pituitary 728523
gene_transcript contains 3 exons of 36, 187, and 1,220 bp and 2 introns of 639 and 1,000 bp 61523