Fmr1 (fragile X messenger ribonucleoprotein 1) - Rat Genome Database

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Gene: Fmr1 (fragile X messenger ribonucleoprotein 1) Rattus norvegicus
Analyze
Symbol: Fmr1
Name: fragile X messenger ribonucleoprotein 1
RGD ID: 2623
Description: Enables RNA binding activity; enzyme binding activity; and protein domain specific binding activity. Involved in several processes, including cellular response to L-glutamate; modulation of chemical synaptic transmission; and regulation of protein metabolic process. Located in several cellular components, including cytoplasmic ribonucleoprotein granule; dendrite; and distal axon. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic cytosol. Used to study autism spectrum disorder and fragile X syndrome. Biomarker of alcohol use disorder; myoclonic-atonic epilepsy; transient cerebral ischemia; and withdrawal disorder. Human ortholog(s) of this gene implicated in fragile X syndrome; fragile X-associated tremor/ataxia syndrome; and primary ovarian insufficiency 1. Orthologous to human FMR1 (fragile X messenger ribonucleoprotein 1); INTERACTS WITH (S)-3,5-dihydroxyphenylglycine; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: FMRP; FMRP translational regulator 1; fragile X mental retardation 1; fragile X mental retardation protein 1 homolog; fragile X mental retardation syndrome 1 homolog; fragile X mental retardation-1 protein; protein FMR-1; ragile X mental retardation protein; synaptic functional regulator FMR1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Fmr1em2Mcwi   Fmr1em4Mcwi   Fmr1em1Sage   Fmr1em1Mzhe   Fmr1em1Pwc  
Genetic Models: SD-Fmr1em1Mzhe LE-Fmr1em4Mcwi LE-Fmr1em2Mcwi SD-Fmr1em1Sage
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X152,284,857 - 152,322,686 (+)NCBIGRCr8
mRatBN7.2X147,240,239 - 147,278,057 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX147,240,301 - 147,278,050 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX149,444,285 - 149,482,036 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X152,978,628 - 153,016,381 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X150,519,276 - 150,557,027 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X154,684,924 - 154,722,369 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
RGSC_v3.4X154,756,031 - 154,793,782 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X154,829,463 - 154,867,215 (+)NCBI
Cytogenetic MapXq37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-3,5-dihydroxyphenylglycine  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2-arachidonoylglycerol  (ISO)
2-methyl-6-(phenylethynyl)pyridine  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-vinylcyclohexene dioxide  (ISO)
acamprosate  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
aminomalonic acid  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
chlorpyrifos  (EXP)
chrysene  (ISO)
cocaine  (EXP)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
D-glucitol  (ISO)
D-threitol  (ISO)
DDE  (EXP)
decabromodiphenyl ether  (ISO)
dibutyl phthalate  (EXP)
dimethyl sulfoxide  (ISO)
ebselen  (ISO)
epoxiconazole  (EXP)
ethanol  (ISO)
ethylbenzene  (ISO)
folic acid  (ISO)
FR900359  (ISO)
furan  (EXP)
hydroxyl  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
lead diacetate  (EXP)
linuron  (EXP)
menadione  (ISO)
methidathion  (ISO)
methoxychlor  (ISO)
minocycline  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel sulfate  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenytoin  (EXP)
poly(I:C)  (ISO)
potassium chloride  (EXP)
potassium chromate  (ISO)
prochloraz  (EXP)
procymidone  (EXP)
quercetin  (ISO)
resveratrol  (EXP,ISO)
rimonabant  (ISO)
senecionine  (ISO)
sodium arsenite  (ISO)
superoxide  (ISO)
suramin  (ISO)
tamoxifen  (ISO)
tetrahydropalmatine  (ISO)
tetraphene  (ISO)
thapsigargin  (EXP)
threitol  (ISO)
threonic acid  (ISO)
toluene  (ISO)
trichostatin A  (ISO)
triptonide  (ISO)
urethane  (ISO)
vigabatrin  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ development  (IBA)
anterograde axonal transport  (ISO)
cellular response to L-glutamate  (IEP)
cellular response to potassium ion  (IEP)
cellular response to virus  (ISO)
central nervous system development  (ISO)
dendritic spine development  (ISO)
detection of mechanical stimulus involved in sensory perception  (IEP)
DNA repair  (ISO,ISS)
evoked excitatory postsynaptic potential  (IMP)
excitatory chemical synaptic transmission  (ISO)
glutamate receptor signaling pathway  (IDA,ISO)
inhibitory chemical synaptic transmission  (ISO)
intracellular glutamate homeostasis  (IMP)
locomotory exploration behavior  (IMP)
miRNA-mediated post-transcriptional gene silencing  (ISO,ISS)
modulation by host of viral RNA genome replication  (ISO)
mRNA export from nucleus  (ISO,ISS)
mRNA processing  (IEA)
mRNA transport  (IBA,IEA,ISO,ISS)
negative regulation of cytoplasmic translation  (ISO,ISS)
negative regulation of gene expression  (IMP,ISO,ISS)
negative regulation of long-term synaptic depression  (ISO,ISS)
negative regulation of miRNA-mediated gene silencing  (ISO,ISS)
negative regulation of neuron apoptotic process  (IMP)
negative regulation of neuron differentiation  (IMP)
negative regulation of protein processing  (IMP)
negative regulation of receptor internalization  (IMP)
negative regulation of synaptic vesicle exocytosis  (IMP)
negative regulation of translation  (IEA,ISO,ISS)
negative regulation of translational initiation  (ISO,ISS)
nervous system development  (IEA)
non-membrane-bounded organelle assembly  (ISO,ISS)
ovarian follicle development  (IEP)
positive regulation of dendritic spine development  (ISO,ISS)
positive regulation of filopodium assembly  (ISO,ISS)
positive regulation of gene expression  (IMP)
positive regulation of intracellular transport of viral material  (ISO)
positive regulation of long-term neuronal synaptic plasticity  (IBA,IMP)
positive regulation of long-term synaptic depression  (IMP)
positive regulation of long-term synaptic potentiation  (IMP)
positive regulation of miRNA-mediated gene silencing  (ISO,ISS)
positive regulation of proteasomal protein catabolic process  (ISO,ISS)
positive regulation of protein phosphorylation  (IEA,IMP)
positive regulation of receptor internalization  (ISO,ISS)
positive regulation of synaptic transmission  (IMP)
positive regulation of translation  (IBA,IEA,ISO,ISS)
regulation of alternative mRNA splicing, via spliceosome  (IEA,ISO,ISS)
regulation of dendritic spine development  (ISO,ISS)
regulation of filopodium assembly  (IEA,ISO,ISS)
regulation of modification of synaptic structure  (ISO)
regulation of mRNA stability  (IBA,IEA,ISO,ISS)
regulation of neuronal action potential  (IMP,ISO,ISS)
regulation of neurotransmitter secretion  (IMP)
regulation of translation  (TAS)
regulation of translation at postsynapse, modulating synaptic transmission  (ISO)
regulation of translation at presynapse, modulating synaptic transmission  (IBA,IDA,IMP)
response to activity  (IEP)
response to cocaine  (IEP)
response to electrical stimulus  (IEP)
response to gonadotropin  (IEP)
response to interleukin-1  (IEP)
response to interleukin-17  (ISO)
response to light stimulus  (IEP)
RNA splicing  (IEA)
skeletal muscle organ development  (ISS)
social behavior  (ISO)
stress granule assembly  (ISO,ISS)
transmission of nerve impulse  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Localization of FMRP-associated mRNA granules and requirement of microtubules for activity-dependent trafficking in hippocampal neurons. Antar LN, etal., Genes Brain Behav. 2005 Aug;4(6):350-9.
2. Metabotropic glutamate receptor activation regulates fragile x mental retardation protein and FMR1 mRNA localization differentially in dendrites and at synapses. Antar LN, etal., J Neurosci 2004 Mar 17;24(11):2648-55.
3. Experience-dependent changes in hippocampal spatial activity and hippocampal circuit function are disrupted in a rat model of Fragile X Syndrome. Asiminas A, etal., Mol Autism. 2022 Dec 20;13(1):49. doi: 10.1186/s13229-022-00528-z.
4. Auditory hypersensitivity and processing deficits in a rat model of fragile X syndrome. Auerbach BD, etal., Neurobiol Dis. 2021 Dec;161:105541. doi: 10.1016/j.nbd.2021.105541. Epub 2021 Oct 29.
5. Phosphorylation of FMRP and alterations of FMRP complex underlie enhanced mLTD in adult rats triggered by early life seizures. Bernard PB, etal., Neurobiol Dis. 2013 Nov;59:1-17. doi: 10.1016/j.nbd.2013.06.013. Epub 2013 Jul 2.
6. Sensory hypo-excitability in a rat model of fetal development in Fragile X Syndrome. Berzhanskaya J, etal., Sci Rep. 2016 Jul 28;6:30769. doi: 10.1038/srep30769.
7. Long-term abstinence from developmental cocaine exposure alters Arc/Arg3.1 modulation in the rat medial prefrontal cortex. Caffino L, etal., Neurotox Res. 2014 Oct;26(3):299-306. doi: 10.1007/s12640-014-9472-1. Epub 2014 May 9.
8. FMR1 deletion in rats induces hyperactivity with no changes in striatal dopamine transporter availability. D'Elia A, etal., Sci Rep. 2022 Dec 29;12(1):22535. doi: 10.1038/s41598-022-26986-2.
9. The nuclear microspherule protein 58 is a novel RNA-binding protein that interacts with fragile X mental retardation protein in polyribosomal mRNPs from neurons. Davidovic L, etal., Hum Mol Genet. 2006 May 1;15(9):1525-38. Epub 2006 Mar 28.
10. The fragile X mental retardation protein is a molecular adaptor between the neurospecific KIF3C kinesin and dendritic RNA granules. Davidovic L, etal., Hum Mol Genet. 2007 Dec 15;16(24):3047-58. Epub 2007 Sep 19.
11. Transport of fragile X mental retardation protein via granules in neurites of PC12 cells. De Diego Otero Y, etal., Mol Cell Biol 2002 Dec;22(23):8332-41.
12. Oxidative stress reveals heterogeneity of FMRP granules in PC12 cell neurites. Dolzhanskaya N, etal., Brain Res. 2006 Sep 27;1112(1):56-64. Epub 2006 Aug 17.
13. Persistence of cerebellar ataxia during chronic ethanol exposure is associated with epigenetic up-regulation of Fmr1 gene expression in rat cerebellum. Dulman RS, etal., Alcohol Clin Exp Res. 2021 Oct;45(10):2006-2016. doi: 10.1111/acer.14691. Epub 2021 Aug 28.
14. Degraded speech sound processing in a rat model of fragile X syndrome. Engineer CT, etal., Brain Res. 2014 May 20;1564:72-84. doi: 10.1016/j.brainres.2014.03.049. Epub 2014 Apr 5.
15. Fragile X mental retardation protein: nucleocytoplasmic shuttling and association with somatodendritic ribosomes. Feng Y, etal., J Neurosci. 1997 Mar 1;17(5):1539-47.
16. Expression of fragile X mental retardation protein and Fmr1 mRNA during folliculogenesis in the rat. Ferder I, etal., Reproduction. 2013 Apr 15;145(4):335-43. doi: 10.1530/REP-12-0305. Print 2013 Apr.
17. Fragile X mental retardation protein controls synaptic vesicle exocytosis by modulating N-type calcium channel density. Ferron L, etal., Nat Commun. 2014 Apr 7;5:3628. doi: 10.1038/ncomms4628.
18. Visual experience regulates transient expression and dendritic localization of fragile X mental retardation protein. Gabel LA, etal., J Neurosci. 2004 Nov 24;24(47):10579-83.
19. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
20. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
21. Deletion of the KH1 Domain of Fmr1 Leads to Transcriptional Alterations and Attentional Deficits in Rats. Golden CEM, etal., Cereb Cortex. 2019 May 1;29(5):2228-2244. doi: 10.1093/cercor/bhz029.
22. Fmr1 and Nlgn3 knockout rats: novel tools for investigating autism spectrum disorders. Hamilton SM, etal., Behav Neurosci. 2014 Apr;128(2):103-9. doi: 10.1037/a0035988.
23. Methylation-dependent gene silencing induced by interleukin 1beta via nitric oxide production. Hmadcha A, etal., J Exp Med. 1999 Dec 6;190(11):1595-604.
24. Ovarian abnormalities in a mouse model of fragile X primary ovarian insufficiency. Hoffman GE, etal., J Histochem Cytochem. 2012 Jun;60(6):439-56. doi: 10.1369/0022155412441002. Epub 2012 Apr 2.
25. Altered synaptic plasticity in a mouse model of fragile X mental retardation. Huber KM, etal., Proc Natl Acad Sci U S A. 2002 May 28;99(11):7746-50.
26. Evidence for altered Fragile-X mental retardation protein expression in response to behavioral stimulation. Irwin SA, etal., Neurobiol Learn Mem. 2000 Jul;74(1):87-93.
27. Translational regulation of NeuroD1 expression by FMRP: involvement in glutamatergic neuronal differentiation of cultured rat primary neural progenitor cells. Jeon SJ, etal., Cell Mol Neurobiol. 2014 Mar;34(2):297-305. doi: 10.1007/s10571-013-0014-9. Epub 2013 Dec 12.
28. Positive feedback regulation of Akt-FMRP pathway protects neurons from cell death. Jeon SJ, etal., J Neurochem. 2012 Oct;123(2):226-38. doi: 10.1111/j.1471-4159.2012.07886.x. Epub 2012 Aug 22.
29. Molecular phenotype of Fragile X syndrome: FMRP, FXRPs, and protein targets. Kaufmann WE, etal., Microsc Res Tech. 2002 May 1;57(3):135-44.
30. Fragile X mental retardation protein shifts between polyribosomes and stress granules after neuronal injury by arsenite stress or in vivo hippocampal electrode insertion. Kim SH, etal., J Neurosci. 2006 Mar 1;26(9):2413-8.
31. Mapping of DNA instability at the fragile X to a trinucleotide repeat sequence p(CCG)n. Kremer EJ, etal., Science. 1991 Jun 21;252(5013):1711-4.
32. Rescue of sharp wave-ripples and prevention of network hyperexcitability in the ventral but not the dorsal hippocampus of a rat model of fragile X syndrome. Leontiadis LJ, etal., Front Cell Neurosci. 2023 Dec 1;17:1296235. doi: 10.3389/fncel.2023.1296235. eCollection 2023.
33. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
34. Robust and replicable measurement for prepulse inhibition of the acoustic startle response. Miller EA, etal., Mol Psychiatry. 2020 Mar 6. pii: 10.1038/s41380-020-0703-y. doi: 10.1038/s41380-020-0703-y.
35. Synaptotagmin 11 interacts with components of the RNA-induced silencing complex RISC in clonal pancreatic beta-cells. Milochau A, etal., FEBS Lett. 2014 Jun 27;588(14):2217-22. doi: 10.1016/j.febslet.2014.05.031. Epub 2014 May 29.
36. Fragile X mental retardation protein deficiency leads to excessive mGluR5-dependent internalization of AMPA receptors. Nakamoto M, etal., Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15537-42. Epub 2007 Sep 19.
37. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
38. Multi-level profiling of the Fmr1 KO rat unveils altered behavioral traits along with aberrant glutamatergic function. Ntoulas G, etal., Transl Psychiatry. 2024 Feb 20;14(1):104. doi: 10.1038/s41398-024-02815-0.
39. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
40. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
41. Two-stage translational control of dentate gyrus LTP consolidation is mediated by sustained BDNF-TrkB signaling to MNK. Panja D, etal., Cell Rep. 2014 Nov 20;9(4):1430-45. doi: 10.1016/j.celrep.2014.10.016. Epub 2014 Nov 6.
42. Brain Cholesterol Biosynthetic Pathway Is Altered in a Preclinical Model of Fragile X Syndrome. Parente M, etal., Int J Mol Sci. 2022 Mar 21;23(6):3408. doi: 10.3390/ijms23063408.
43. The RNA binding and transport proteins staufen and fragile X mental retardation protein are expressed by rat primary afferent neurons and localize to peripheral and central axons. Price TJ, etal., Neuroscience. 2006 Sep 15;141(4):2107-16. Epub 2006 Jun 30.
44. GOA pipeline RGD automated data pipeline
45. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
46. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
47. Abnormal neuronal morphology and neurochemistry in the auditory brainstem of Fmr1 knockout rats. Ruby K, etal., Neuroscience. 2015 Sep 10;303:285-98. doi: 10.1016/j.neuroscience.2015.06.061. Epub 2015 Jul 9.
48. Loss of FMRP Impaired Hippocampal Long-Term Plasticity and Spatial Learning in Rats. Tian Y, etal., Front Mol Neurosci. 2017 Aug 28;10:269. doi: 10.3389/fnmol.2017.00269. eCollection 2017.
49. Whisker stimulation-dependent translation of FMRP in the barrel cortex requires activation of type I metabotropic glutamate receptors. Todd PK, etal., Brain Res Mol Brain Res. 2003 Feb 20;110(2):267-78.
50. Fragile X (fmr1) mRNA expression is differentially regulated in two adult models of activity-dependent gene expression. Valentine G, etal., Brain Res Mol Brain Res. 2000 Feb 22;75(2):337-41.
51. Cognitive decline, neuromotor and behavioural disturbances in a mouse model for fragile-X-associated tremor/ataxia syndrome (FXTAS). Van Dam D, etal., Behav Brain Res. 2005 Jul 30;162(2):233-9.
52. Developmentally-programmed FMRP expression in oligodendrocytes: a potential role of FMRP in regulating translation in oligodendroglia progenitors. Wang H, etal., Hum Mol Genet. 2004 Jan 1;13(1):79-89. Epub 2003 Nov 12.
53. Fragile X mental retardation protein is translated near synapses in response to neurotransmitter activation. Weiler IJ, etal., Proc Natl Acad Sci U S A. 1997 May 13;94(10):5395-400.
54. The Potential Role of PKA/CREB Signaling Pathway Concerned with Gastrodin Administration on Methamphetamine-Induced Conditioned Place Preference Rats and SH-SY5Y Cell Line. Yang GM, etal., Neurotox Res. 2020 Apr;37(4):926-935. doi: 10.1007/s12640-019-00150-7. Epub 2020 Jan 4.
Additional References at PubMed
PMID:7489725   PMID:7688265   PMID:8156595   PMID:9659908   PMID:10496225   PMID:11157796   PMID:11376146   PMID:11438589   PMID:12700164   PMID:12927206   PMID:15121898   PMID:15380484  
PMID:15381419   PMID:15805463   PMID:16055059   PMID:16631377   PMID:16790844   PMID:17057366   PMID:17254795   PMID:17417632   PMID:17850748   PMID:18093976   PMID:18539120   PMID:18614030  
PMID:18653529   PMID:18805096   PMID:18936162   PMID:19097999   PMID:19166269   PMID:19193898   PMID:19946888   PMID:20159450   PMID:21446998   PMID:21933836   PMID:22022532   PMID:22357842  
PMID:22658674   PMID:22681889   PMID:23235829   PMID:23509247   PMID:24204304   PMID:24349419   PMID:24514761   PMID:24658146   PMID:24813610   PMID:25225333   PMID:25464849   PMID:25561520  
PMID:26037301   PMID:26586091   PMID:26627310   PMID:27666021   PMID:30053369   PMID:30361391   PMID:30969437   PMID:31291981   PMID:31413325   PMID:32452512   PMID:32788572   PMID:33139785  
PMID:33407653   PMID:34327719   PMID:34338322   PMID:34996816   PMID:35436530   PMID:35641906   PMID:36116785   PMID:36849416  


Genomics

Comparative Map Data
Fmr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X152,284,857 - 152,322,686 (+)NCBIGRCr8
mRatBN7.2X147,240,239 - 147,278,057 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX147,240,301 - 147,278,050 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX149,444,285 - 149,482,036 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X152,978,628 - 153,016,381 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X150,519,276 - 150,557,027 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X154,684,924 - 154,722,369 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
RGSC_v3.4X154,756,031 - 154,793,782 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X154,829,463 - 154,867,215 (+)NCBI
Cytogenetic MapXq37NCBI
FMR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X147,911,919 - 147,951,125 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX147,911,919 - 147,951,125 (+)EnsemblGRCh38hg38GRCh38
GRCh37X146,993,437 - 147,032,645 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X146,801,201 - 146,840,303 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X146,699,054 - 146,738,157NCBI
CeleraX147,345,446 - 147,384,585 (+)NCBICelera
Cytogenetic MapXq27.3NCBI
HuRefX135,963,879 - 135,993,282 (+)NCBIHuRef
CHM1_1X146,904,323 - 146,943,501 (+)NCBICHM1_1
T2T-CHM13v2.0X146,176,547 - 146,215,797 (+)NCBIT2T-CHM13v2.0
Fmr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X67,722,144 - 67,761,569 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX67,722,147 - 67,761,569 (+)EnsemblGRCm39 Ensembl
GRCm38X68,678,536 - 68,717,963 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX68,678,541 - 68,717,963 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X65,931,730 - 65,971,138 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X51,835,932 - 51,875,340 (+)NCBIMGSCv36mm8
MGSCv36X64,939,220 - 64,978,628 (+)NCBIMGSCv36mm8
Cytogenetic MapXA7.1NCBI
cM MapX34.83NCBI
Fmr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955498566,688 - 595,360 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955498566,741 - 594,837 (+)NCBIChiLan1.0ChiLan1.0
FMR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X147,227,441 - 147,266,218 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X147,231,048 - 147,269,765 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X136,937,889 - 136,976,828 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X147,366,713 - 147,405,327 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX147,365,748 - 147,405,321 (+)Ensemblpanpan1.1panPan2
FMR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X116,249,079 - 116,287,008 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX116,249,142 - 116,321,439 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX102,141,952 - 102,179,858 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X118,308,237 - 118,346,144 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX118,308,224 - 118,346,195 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X115,421,122 - 115,459,027 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X117,632,687 - 117,670,590 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X117,359,050 - 117,396,958 (+)NCBIUU_Cfam_GSD_1.0
Fmr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X114,286,773 - 114,324,847 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365131,289,558 - 1,327,856 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365131,290,038 - 1,327,850 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FMR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX120,361,367 - 120,399,831 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X120,361,232 - 120,400,282 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X137,792,642 - 137,831,753 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FMR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X122,635,383 - 122,674,298 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX122,635,439 - 122,674,355 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606560,266,278 - 60,318,872 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fmr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624883645,449 - 682,292 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624883645,524 - 681,705 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fmr1
20 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:728
Count of miRNA genes:298
Interacting mature miRNAs:385
Transcripts:ENSRNOT00000016228
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX100567703150256146Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X103312877148312877Rat
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X103312877148312877Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X113937816152453651Rat
634346Insul4Insulin level QTL 40blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)X126975089152453651Rat

Markers in Region
L23971  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X147,276,203 - 147,276,383 (-)MAPPERmRatBN7.2
Rnor_6.0X154,686,598 - 154,686,777NCBIRnor6.0
Rnor_6.0X154,498,788 - 154,498,967NCBIRnor6.0
Rnor_5.01150,221,481 - 150,221,660UniSTSRnor5.0
Rnor_5.01150,409,894 - 150,410,073UniSTSRnor5.0
RGSC_v3.4X154,791,934 - 154,792,113UniSTSRGSC3.4
Celera1134,094,059 - 134,094,238UniSTS
Cytogenetic MapXq37UniSTS
GDB:342159  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X147,240,416 - 147,240,512 (-)MAPPERmRatBN7.2
Rnor_6.0X154,722,103 - 154,722,198NCBIRnor6.0
Rnor_5.01150,445,399 - 150,445,494UniSTSRnor5.0
RGSC_v3.4X154,756,147 - 154,756,242UniSTSRGSC3.4
Celera1134,129,930 - 134,130,025UniSTS
Cytogenetic MapXq37UniSTS
GDB:370773  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X147,258,915 - 147,259,237 (-)MAPPERmRatBN7.2
Rnor_6.0X154,703,378 - 154,703,699NCBIRnor6.0
Rnor_5.01150,426,674 - 150,426,995UniSTSRnor5.0
RGSC_v3.4X154,774,646 - 154,774,967UniSTSRGSC3.4
Celera1134,111,205 - 134,111,526UniSTS
Cytogenetic MapXq37UniSTS


Genetic Models
This gene Fmr1 is modified in the following models/strains:


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 34 55 39 19 39 6 6 74 34 36 11 6
Low 9 2 2 2 2 5 1 5 2
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_052804 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF435434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY224680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY240947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY630337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JX901077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JX901078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JX901079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JX901080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JX901081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JX901082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JX901083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MZ044289 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MZ711224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U60145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000087893   ⟹   ENSRNOP00000074033
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX147,240,301 - 147,278,046 (+)Ensembl
Rnor_6.0 EnsemblX154,684,935 - 154,722,314 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000089743   ⟹   ENSRNOP00000071204
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX147,240,408 - 147,278,050 (+)Ensembl
Rnor_6.0 EnsemblX154,684,938 - 154,722,220 (-)Ensembl
RefSeq Acc Id: NM_052804   ⟹   NP_434691
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X152,284,930 - 152,322,681 (+)NCBI
mRatBN7.2X147,240,301 - 147,278,052 (+)NCBI
Rnor_6.0X154,684,929 - 154,722,314 (-)NCBI
Rnor_5.01150,408,220 - 150,445,658 (-)NCBI
RGSC_v3.4X154,756,031 - 154,793,782 (+)RGD
Celera1134,092,390 - 134,130,141 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006229530   ⟹   XP_006229592
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X152,284,858 - 152,322,686 (+)NCBI
mRatBN7.2X147,240,240 - 147,278,057 (+)NCBI
Rnor_6.0X154,684,924 - 154,722,369 (-)NCBI
Rnor_5.01150,408,220 - 150,445,658 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006229531   ⟹   XP_006229593
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X152,284,858 - 152,322,686 (+)NCBI
mRatBN7.2X147,240,240 - 147,278,057 (+)NCBI
Rnor_6.0X154,684,924 - 154,722,369 (-)NCBI
Rnor_5.01150,408,220 - 150,445,658 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006229532   ⟹   XP_006229594
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X152,284,857 - 152,322,686 (+)NCBI
mRatBN7.2X147,240,241 - 147,278,057 (+)NCBI
Rnor_6.0X154,684,924 - 154,722,369 (-)NCBI
Rnor_5.01150,408,220 - 150,445,658 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017601917   ⟹   XP_017457406
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X152,284,866 - 152,322,686 (+)NCBI
mRatBN7.2X147,240,240 - 147,278,057 (+)NCBI
Rnor_6.0X154,684,924 - 154,722,369 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017601918   ⟹   XP_017457407
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X152,284,866 - 152,322,686 (+)NCBI
mRatBN7.2X147,240,241 - 147,278,057 (+)NCBI
Rnor_6.0X154,684,924 - 154,722,368 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039099491   ⟹   XP_038955419
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X152,284,866 - 152,315,364 (+)NCBI
mRatBN7.2X147,240,239 - 147,270,583 (+)NCBI
RefSeq Acc Id: XM_063279814   ⟹   XP_063135884
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X152,284,871 - 152,322,686 (+)NCBI
RefSeq Acc Id: XM_063279815   ⟹   XP_063135885
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X152,296,033 - 152,322,686 (+)NCBI
RefSeq Acc Id: XM_063279816   ⟹   XP_063135886
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X152,285,147 - 152,322,686 (+)NCBI
Protein Sequences
Protein RefSeqs NP_434691 (Get FASTA)   NCBI Sequence Viewer  
  XP_006229592 (Get FASTA)   NCBI Sequence Viewer  
  XP_006229593 (Get FASTA)   NCBI Sequence Viewer  
  XP_006229594 (Get FASTA)   NCBI Sequence Viewer  
  XP_017457406 (Get FASTA)   NCBI Sequence Viewer  
  XP_017457407 (Get FASTA)   NCBI Sequence Viewer  
  XP_038955419 (Get FASTA)   NCBI Sequence Viewer  
  XP_063135884 (Get FASTA)   NCBI Sequence Viewer  
  XP_063135885 (Get FASTA)   NCBI Sequence Viewer  
  XP_063135886 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB07073 (Get FASTA)   NCBI Sequence Viewer  
  AAL31971 (Get FASTA)   NCBI Sequence Viewer  
  AAP15341 (Get FASTA)   NCBI Sequence Viewer  
  AAT48080 (Get FASTA)   NCBI Sequence Viewer  
  AGO58385 (Get FASTA)   NCBI Sequence Viewer  
  AGO58386 (Get FASTA)   NCBI Sequence Viewer  
  AGO58387 (Get FASTA)   NCBI Sequence Viewer  
  AGO58388 (Get FASTA)   NCBI Sequence Viewer  
  AGO58389 (Get FASTA)   NCBI Sequence Viewer  
  AGO58390 (Get FASTA)   NCBI Sequence Viewer  
  AGO58391 (Get FASTA)   NCBI Sequence Viewer  
  EDL84465 (Get FASTA)   NCBI Sequence Viewer  
  EDL84467 (Get FASTA)   NCBI Sequence Viewer  
  EDL84468 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000071204
  ENSRNOP00000071204.1
  ENSRNOP00000074033
  ENSRNOP00000074033.1
  ENSRNOP00055033609
  ENSRNOP00060026912
  ENSRNOP00065029638
GenBank Protein Q80WE1 (Get FASTA)   NCBI Sequence Viewer  
  QWY17699 (Get FASTA)   NCBI Sequence Viewer  
  UYC28830 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_434691   ⟸   NM_052804
- UniProtKB: A6KQ97 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229593   ⟸   XM_006229531
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006229592   ⟸   XM_006229530
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JZV8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229594   ⟸   XM_006229532
- Peptide Label: isoform X3
- UniProtKB: P70568 (UniProtKB/Swiss-Prot),   Q80WE1 (UniProtKB/Swiss-Prot),   A6KQ98 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017457406   ⟸   XM_017601917
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_017457407   ⟸   XM_017601918
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: ENSRNOP00000074033   ⟸   ENSRNOT00000087893
RefSeq Acc Id: ENSRNOP00000071204   ⟸   ENSRNOT00000089743
RefSeq Acc Id: XP_038955419   ⟸   XM_039099491
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063135884   ⟸   XM_063279814
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063135886   ⟸   XM_063279816
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063135885   ⟸   XM_063279815
- Peptide Label: isoform X6
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q80WE1-F1-model_v2 AlphaFold Q80WE1 1-593 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13702059
Promoter ID:EPDNEW_R12558
Type:multiple initiation site
Name:Fmr1_2
Description:fragile X mental retardation 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R12559  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X154,722,256 - 154,722,316EPDNEW
RGD ID:13702037
Promoter ID:EPDNEW_R12559
Type:multiple initiation site
Name:Fmr1_1
Description:fragile X mental retardation 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R12558  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X154,722,359 - 154,722,419EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2623 AgrOrtholog
BioCyc Gene G2FUF-740 BioCyc
Ensembl Genes ENSRNOG00000057464 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055023990 UniProtKB/Swiss-Prot
  ENSRNOG00060018894 UniProtKB/Swiss-Prot
  ENSRNOG00065021607 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000087893 ENTREZGENE
  ENSRNOT00000087893.2 UniProtKB/Swiss-Prot
  ENSRNOT00000089743.2 UniProtKB/TrEMBL
  ENSRNOT00055041306 UniProtKB/Swiss-Prot
  ENSRNOT00060032915 UniProtKB/Swiss-Prot
  ENSRNOT00065036800 UniProtKB/Swiss-Prot
Gene3D-CATH 2.30.30.140 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.1370.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Agenet-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FMR1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FMRP_KH0 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FXMR_C2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FXMRP1_C_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KH_dom_type_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KH_dom_type_1_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KH_I_FMR1_rpt1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KH_I_FMR1_rpt2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tudor_Agenet_FMR1_rpt1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tudor_Agenet_FMR1_rpt2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tudor_FRX1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24948 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 24948 ENTREZGENE
PANTHER PTHR10603 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SYNAPTIC FUNCTIONAL REGULATOR FMR1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Agenet UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FXMR_C2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FXMRP1_C_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KH_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KH_9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tudor_FRX1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fmr1 PhenoGen
PROSITE AGENET_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KH_TYPE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000057464 RatGTEx
  ENSRNOG00055023990 RatGTEx
  ENSRNOG00060018894 RatGTEx
  ENSRNOG00065021607 RatGTEx
SMART SM00322 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54791 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A067XMK2_RAT UniProtKB/TrEMBL
  A0A067XMN7_RAT UniProtKB/TrEMBL
  A0A067XMS9_RAT UniProtKB/TrEMBL
  A0A067XMV0_RAT UniProtKB/TrEMBL
  A0A067XMV1_RAT UniProtKB/TrEMBL
  A0A067XNH0_RAT UniProtKB/TrEMBL
  A0A0G2JZV8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8F2PZN5_RAT UniProtKB/TrEMBL
  A0A8F3CCW8_RAT UniProtKB/TrEMBL
  A6KQ97 ENTREZGENE, UniProtKB/TrEMBL
  A6KQ98 ENTREZGENE, UniProtKB/TrEMBL
  FMR1_RAT UniProtKB/Swiss-Prot
  P70568 ENTREZGENE
  Q6GWE1_RAT UniProtKB/TrEMBL
  Q80WE1 ENTREZGENE
UniProt Secondary P70568 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-04-01 Fmr1  fragile X messenger ribonucleoprotein 1  Fmr1  FMRP translational regulator 1  Name changed 629549 APPROVED
2008-10-29 Fmr1  fragile X mental retardation 1  Fmr1  fragile X mental retardation syndrome 1 homolog  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Fmr1  Fragile X mental retardation 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease mutation of the human homolog causes the fragile X mental retardation syndrome 628492
gene_domains contains RNA-binding motifs, two KH domains and an RGG box 628492
gene_expression ubiquitous; abundant in neurons and spermatogonia (testis) 628492
gene_function an RNA binding protein 628492
gene_physical_interaction associates with ribosomes and interacts with kinesin heavy chain and FXR1P 628492
gene_process plays a role in translation and trafficking of mRNAs 628492