Fbp1 (fructose-bisphosphatase 1) - Rat Genome Database

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Gene: Fbp1 (fructose-bisphosphatase 1) Rattus norvegicus
Analyze
Symbol: Fbp1
Name: fructose-bisphosphatase 1
RGD ID: 2595
Description: Enables fructose 1,6-bisphosphate 1-phosphatase activity and monosaccharide binding activity. Involved in several processes, including cellular response to cAMP; cellular response to phorbol 13-acetate 12-myristate; and cellular response to salt stress. Located in extracellular space. Human ortholog(s) of this gene implicated in fructose-1,6-bisphosphatase deficiency. Orthologous to human FBP1 (fructose-bisphosphatase 1); PARTICIPATES IN gluconeogenesis pathway; glycolysis/gluconeogenesis pathway; fructose and mannose metabolic pathway; INTERACTS WITH (+)-schisandrin B; (-)-epigallocatechin 3-gallate; 1-benzylpiperazine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: D-fructose-1,6-bisphosphate 1-phosphohydrolase 1; FBPase 1; Fdp; Fructose-1,6- biphosphatase; fructose-1,6- biphosphatase 1; fructose-1,6-bisphosphatase 1; Fructose-16- biphosphatase; fructose-16-bisphosphatase 1; liver FBPase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8172,212,941 - 2,235,749 (+)NCBIGRCr8
GRCr8 Ensembl172,213,492 - 2,235,746 (+)EnsemblGRCr8 Ensembl
mRatBN7.2172,207,271 - 2,230,076 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl172,208,031 - 2,230,071 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx172,226,670 - 2,248,706 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0173,769,275 - 3,791,309 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0172,224,130 - 2,246,168 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.017396,175 - 417,480 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl17396,180 - 417,480 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.017391,323 - 412,426 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4177,795,717 - 7,818,041 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera17294,875 - 316,917 (-)NCBICelera
RGSC_v3.1177,795,716 - 7,818,038 (+)NCBI
RH 3.4 Map175.6RGD
Cytogenetic Map17p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-benzylpiperazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (EXP,ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrabromodibenzodioxine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amiodarone  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
apigenin  (ISO)
arsenous acid  (ISO)
ATP  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-D-fructofuranose 2,6-bisphosphate  (ISO)
bifenthrin  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chlorpromazine  (ISO)
chromium trinitrate  (ISO)
chromium(6+)  (ISO)
chrysin  (ISO)
cisplatin  (EXP)
citronellol  (EXP)
clofibrate  (EXP)
clofibric acid  (EXP)
cobalt dichloride  (EXP)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
D-glucopyranose 6-phosphate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
diethyl maleate  (EXP)
dimethylarsinic acid  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
fipronil  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
fructose  (EXP)
fumonisin B1  (ISO)
furan  (EXP)
gentamycin  (EXP)
glyceraldehyde 3-phosphate  (ISO)
glycidyl methacrylate  (ISO)
glyphosate  (ISO)
GSK-J4  (ISO)
hexadecanoic acid  (ISO)
hydrazine  (EXP)
inulin  (ISO)
isotretinoin  (ISO)
kaempferol  (ISO)
L-ascorbic acid  (ISO)
L-ethionine  (EXP)
lipopolysaccharide  (ISO)
luteolin  (ISO)
mangiferin  (ISO)
metformin  (EXP)
methapyrilene  (EXP,ISO)
methylarsonic acid  (ISO)
Muraglitazar  (EXP)
myricetin  (ISO)
N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide  (ISO)
N-nitrosomorpholine  (EXP)
naphthalene  (ISO)
nitrofen  (EXP)
O-methyleugenol  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP)
okadaic acid  (ISO)
omeprazole  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
selenic acid  (ISO)
selenium atom  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chlorate  (EXP)
sodium dichromate  (ISO)
streptozocin  (EXP)
succimer  (ISO)
tamibarotene  (ISO)
taurine  (ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (EXP)
tunicamycin  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vanillin  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISO,ISS)
cytosol  (IBA)
extracellular space  (IDA)
nucleus  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Liver fructose-1,6-bisphosphatase cDNA: trans-complementation of fission yeast and characterization of two human transcripts. Bertolotti R, etal., Differentiation 1995 Jul;59(1):51-60.
2. Key enzymes of carbohydrate metabolism as targets of the 11.5-kDa Zn(2+)-binding protein (parathymosin). Brand IA and Heinickel A, J Biol Chem. 1991 Nov 5;266(31):20984-9.
3. Lipid changes during hemodialysis Cerezo Morales S, etal., Rev Clin Esp 1978 Jan 31;148(2):181-5.
4. The rat fructose-1,6-bisphosphatase gene. Structure and regulation of expression. el-Maghrabi MR, etal., J Biol Chem 1991 Feb 5;266(4):2115-20.
5. cDNA sequence of rat liver fructose-1,6-bisphosphatase and evidence for down-regulation of its mRNA by insulin. el-Maghrabi MR, etal., Proc Natl Acad Sci U S A 1988 Nov;85(22):8430-4.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Lupinus albus Conglutin Gamma Modifies the Gene Expressions of Enzymes Involved in Glucose Hepatic Production In Vivo. González-Santiago AE, etal., Plant Foods Hum Nutr. 2017 Jun;72(2):134-140. doi: 10.1007/s11130-016-0597-7.
9. Nutrigenomic effects of germinated brown rice and its bioactives on hepatic gluconeogenic genes in type 2 diabetic rats and HEPG2 cells. Imam MU and Ismail M, Mol Nutr Food Res. 2013 Mar;57(3):401-11. doi: 10.1002/mnfr.201200429. Epub 2013 Jan 10.
10. Cell volume regulates liver phosphoenolpyruvate carboxykinase and fructose-1,6-bisphosphatase genes. Kaiser S, Am J Physiol. 1998 Mar;274(3):G509-17. doi: 10.1152/ajpgi.1998.274.3.G509.
11. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
12. Identification of a genetic mutation in a family with fructose-1,6- bisphosphatase deficiency. Kikawa Y, etal., Biochem Biophys Res Commun. 1995 May 25;210(3):797-804.
13. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
18. GOA pipeline RGD automated data pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Cold acclimation reduces hepatic protein Kinase B and AMP-activated protein kinase phosphorylation and increases gluconeogenesis in Rats. Sepa-Kishi DM, etal., Physiol Rep. 2018 Mar;6(5). doi: 10.14814/phy2.13592.
22. Mechanism of fat-induced hepatic gluconeogenesis: effect of metformin. Song S, etal., Am J Physiol Endocrinol Metab. 2001 Aug;281(2):E275-82.
23. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
24. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
25. PROPERTIES OF PHOSPHOFRUCTOKINASE FROM RAT LIVER AND THEIR RELATION TO THE CONTROL OF GLYCOLYSIS AND GLUCONEOGENESIS. UNDERWOOD AH and NEWSHOLME EA, Biochem J. 1965 Jun;95:868-75.
26. Fructose-1,6-biphosphatase activity in the intestinal mucosa of developing rats. Westbury K and Hahn P, Am J Physiol 1984 Jun;246(6 Pt 1):G683-6.
27. Induction and suppression of the key enzymes of glycolysis and gluconeogenesis in isolated perfused rat liver in response to glucose, fructose and lactate. Wimhurst JM and Manchester KL, Biochem J. 1973 May;134(1):143-56.
28. The expression of FBP1 after traumatic brain injury and its role in astrocyte proliferation. Zhao W, etal., J Mol Neurosci. 2013 Nov;51(3):687-94. doi: 10.1007/s12031-013-0049-x.
Additional References at PubMed
PMID:6305949   PMID:7558035   PMID:8387495   PMID:10222032   PMID:15489334   PMID:15965961   PMID:16169070   PMID:16189514   PMID:16396499   PMID:16442285   PMID:18650089   PMID:19056867  
PMID:19259699   PMID:19881551   PMID:20096900   PMID:21516116   PMID:23376485   PMID:23533145   PMID:23939805   PMID:25043030   PMID:25416956   PMID:25502805   PMID:25910212   PMID:26417114  
PMID:31515488  


Genomics

Comparative Map Data
Fbp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8172,212,941 - 2,235,749 (+)NCBIGRCr8
GRCr8 Ensembl172,213,492 - 2,235,746 (+)EnsemblGRCr8 Ensembl
mRatBN7.2172,207,271 - 2,230,076 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl172,208,031 - 2,230,071 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx172,226,670 - 2,248,706 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0173,769,275 - 3,791,309 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0172,224,130 - 2,246,168 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.017396,175 - 417,480 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl17396,180 - 417,480 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.017391,323 - 412,426 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4177,795,717 - 7,818,041 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera17294,875 - 316,917 (-)NCBICelera
RGSC_v3.1177,795,716 - 7,818,038 (+)NCBI
RH 3.4 Map175.6RGD
Cytogenetic Map17p14NCBI
FBP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38994,603,133 - 94,640,263 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl994,603,133 - 94,640,249 (-)EnsemblGRCh38hg38GRCh38
GRCh37997,365,415 - 97,402,545 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36996,405,236 - 96,441,624 (-)NCBINCBI36Build 36hg18NCBI36
Build 34994,444,977 - 94,481,358NCBI
Celera967,806,446 - 67,843,550 (-)NCBICelera
Cytogenetic Map9q22.32NCBI
HuRef966,974,069 - 67,011,150 (-)NCBIHuRef
CHM1_1997,511,867 - 97,548,958 (-)NCBICHM1_1
T2T-CHM13v2.09106,772,462 - 106,809,573 (-)NCBIT2T-CHM13v2.0
Fbp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391363,012,567 - 63,036,112 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1363,012,567 - 63,036,096 (-)EnsemblGRCm39 Ensembl
GRCm381362,864,753 - 62,888,298 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1362,864,753 - 62,888,282 (-)EnsemblGRCm38mm10GRCm38
MGSCv371362,966,113 - 62,989,596 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361362,874,376 - 62,897,859 (-)NCBIMGSCv36mm8
Celera1364,525,124 - 64,552,462 (-)NCBICelera
Cytogenetic Map13B3NCBI
cM Map1332.74NCBI
Fbp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542221,536,667 - 21,569,433 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542221,537,337 - 21,569,174 (-)NCBIChiLan1.0ChiLan1.0
FBP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21144,817,885 - 44,855,493 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1944,820,279 - 44,857,884 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0965,695,082 - 65,731,628 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1993,825,142 - 93,860,968 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl993,825,150 - 93,860,968 (-)Ensemblpanpan1.1panPan2
FBP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1172,099,886 - 72,125,266 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl172,099,881 - 72,125,224 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha172,861,998 - 72,887,376 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0172,404,539 - 72,429,921 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl172,404,165 - 72,429,918 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1172,215,481 - 72,240,826 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0171,981,002 - 72,006,401 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0172,686,298 - 72,711,910 (+)NCBIUU_Cfam_GSD_1.0
Fbp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049444,327,489 - 4,353,383 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366263,555,762 - 3,581,659 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366263,555,835 - 3,581,651 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FBP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1027,588,570 - 27,622,674 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11027,588,609 - 27,622,225 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21031,712,560 - 31,829,432 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FBP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.112108,452,856 - 108,484,052 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl12108,453,156 - 108,483,775 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603896,849,781 - 96,881,775 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fbp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475316,016,022 - 16,048,104 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475316,019,546 - 16,048,096 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fbp1
69 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:98
Count of miRNA genes:79
Interacting mature miRNAs:87
Transcripts:ENSRNOT00000023685
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131706603Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17136045694Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17143999106Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17143999106Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17143999106Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)17212084322087569Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)17121499218Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17212084342054133Rat
1549900Iddm20Insulin dependent diabetes mellitus QTL 203.7pancreas integrity trait (VT:0010560)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)17122181410Rat
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122877318Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17138037084Rat

Markers in Region
D17Mgh1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8172,235,113 - 2,235,262 (+)Marker Load Pipeline
mRatBN7.2172,229,442 - 2,229,589 (-)MAPPERmRatBN7.2
Rnor_6.017396,662 - 396,810NCBIRnor6.0
Rnor_5.017391,810 - 391,958UniSTSRnor5.0
RGSC_v3.4177,817,406 - 7,817,554UniSTSRGSC3.4
RGSC_v3.4177,817,405 - 7,817,554RGDRGSC3.4
Celera17295,362 - 295,510UniSTS
RGSC_v3.1177,817,405 - 7,817,554RGD
RH 3.4 Map178.3RGD
RH 3.4 Map178.3UniSTS
RH 2.0 Map170.0RGD
Cytogenetic Map17p14UniSTS
D17Mgh10  
Rat AssemblyChrPosition (strand)SourceJBrowse
SHRSP x BN Map174.8501RGD
SHRSP x BN Map174.8501UniSTS
Cytogenetic Map17p14UniSTS
D17Wox22  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2172,229,447 - 2,229,608 (-)MAPPERmRatBN7.2
Rnor_6.017396,643 - 396,805NCBIRnor6.0
Rnor_5.017391,791 - 391,953UniSTSRnor5.0
RGSC_v3.4177,817,411 - 7,817,573UniSTSRGSC3.4
Celera17295,343 - 295,505UniSTS
Cytogenetic Map17p14UniSTS
RH131994  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2172,229,689 - 2,229,897 (-)MAPPERmRatBN7.2
Rnor_6.017396,354 - 396,561NCBIRnor6.0
Rnor_5.017391,502 - 391,709UniSTSRnor5.0
RGSC_v3.4177,817,655 - 7,817,862UniSTSRGSC3.4
Celera17295,054 - 295,261UniSTS
Cytogenetic Map17p14UniSTS
RH94781  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2172,229,835 - 2,230,055 (-)MAPPERmRatBN7.2
Rnor_6.017396,196 - 396,415NCBIRnor6.0
Rnor_5.017391,344 - 391,563UniSTSRnor5.0
RGSC_v3.4177,817,801 - 7,818,020UniSTSRGSC3.4
Celera17294,896 - 295,115UniSTS
RH 3.4 Map175.6UniSTS
Cytogenetic Map17p14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 11 35 110 90 90 59 23 59 6 201 80 2 91 45 60 31 6 6

Sequence


Ensembl Acc Id: ENSRNOT00000023685   ⟹   ENSRNOP00000023685
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl172,213,492 - 2,235,746 (+)Ensembl
mRatBN7.2 Ensembl172,208,031 - 2,230,071 (+)Ensembl
Rnor_6.0 Ensembl17396,180 - 417,480 (-)Ensembl
RefSeq Acc Id: NM_012558   ⟹   NP_036690
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8172,213,707 - 2,235,749 (+)NCBI
mRatBN7.2172,208,031 - 2,230,076 (+)NCBI
Rnor_6.017396,175 - 417,480 (-)NCBI
Rnor_5.017391,323 - 412,426 (-)NCBI
RGSC_v3.4177,795,717 - 7,818,041 (+)RGD
Celera17294,875 - 316,917 (-)RGD
Sequence:
RefSeq Acc Id: XM_039095342   ⟹   XP_038951270
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8172,212,941 - 2,235,749 (+)NCBI
mRatBN7.2172,207,271 - 2,230,076 (+)NCBI
RefSeq Acc Id: NP_036690   ⟸   NM_012558
- UniProtKB: Q64594 (UniProtKB/Swiss-Prot),   P19112 (UniProtKB/Swiss-Prot),   A6KQB3 (UniProtKB/TrEMBL),   F1LRT1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023685   ⟸   ENSRNOT00000023685
RefSeq Acc Id: XP_038951270   ⟸   XM_039095342
- Peptide Label: isoform X1
Protein Domains
Fructose-1-6-bisphosphatase class 1 C-terminal   Fructose-1-6-bisphosphatase class I N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P19112-F1-model_v2 AlphaFold P19112 1-363 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700257
Promoter ID:EPDNEW_R10780
Type:multiple initiation site
Name:Fbp1_1
Description:fructose-bisphosphatase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.017417,382 - 417,442EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2595 AgrOrtholog
BioCyc Gene G2FUF-10512 BioCyc
BioCyc Pathway PWY66-399 [gluconeogenesis III] BioCyc
BioCyc Pathway Image PWY66-399 BioCyc
Ensembl Genes ENSRNOG00000017597 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000023685 ENTREZGENE
  ENSRNOT00000023685.7 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.190.80 UniProtKB/Swiss-Prot
  Fructose-1,6-Bisphosphatase, subunit A, domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7114766 IMAGE-MGC_LOAD
  IMAGE:7134943 IMAGE-MGC_LOAD
InterPro FBPase_C_dom UniProtKB/Swiss-Prot
  FBPase_class-1 UniProtKB/Swiss-Prot
  FBPase_N UniProtKB/Swiss-Prot
  FBPtase UniProtKB/Swiss-Prot
  Fructose_bisphosphatase_AS UniProtKB/Swiss-Prot
KEGG Report rno:24362 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93619 IMAGE-MGC_LOAD
  MGC:93620 IMAGE-MGC_LOAD
NCBI Gene 24362 ENTREZGENE
PANTHER FRUCTOSE-1,6-BISPHOSPHATASE 1 UniProtKB/Swiss-Prot
  PTHR11556 UniProtKB/Swiss-Prot
Pfam FBPase UniProtKB/Swiss-Prot
  FBPase_C UniProtKB/Swiss-Prot
PhenoGen Fbp1 PhenoGen
PIRSF FBPtase UniProtKB/Swiss-Prot
  FBPtase_SBPase UniProtKB/Swiss-Prot
PRINTS F16BPHPHTASE UniProtKB/Swiss-Prot
PROSITE FBPASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017597 RatGTEx
Superfamily-SCOP Carbohydrate phosphatase UniProtKB/Swiss-Prot
UniProt A6KQB3 ENTREZGENE, UniProtKB/TrEMBL
  F16P1_RAT UniProtKB/Swiss-Prot
  F1LRT1 ENTREZGENE, UniProtKB/TrEMBL
  P19112 ENTREZGENE
  Q64594 ENTREZGENE
UniProt Secondary Q64594 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-02 Fbp1  fructose-bisphosphatase 1  Fbp1  fructose-1,6-bisphosphatase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-10-22 Fbp1  fructose-1,6-bisphosphatase 1  Fbp1  fructose-1,6- biphosphatase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Fbp1  fructose-1,6- biphosphatase 1    fructose-1,6-bisphosphatase 1  Name updated 629478 APPROVED
2002-06-10 Fbp1  fructose-1,6-bisphosphatase 1      Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_function catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate 635271
gene_process regulatory enzyme in gluconeogenesis 635271
gene_regulation inhibited by AMP, affecting the turnover of bound substrate and not the affinity for substrate 635271