F3 (coagulation factor III, tissue factor) - Rat Genome Database

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Gene: F3 (coagulation factor III, tissue factor) Rattus norvegicus
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Symbol: F3
Name: coagulation factor III, tissue factor
RGD ID: 2587
Description: Enables protease binding activity. Involved in several processes, including cellular response to hydrogen peroxide; positive regulation of smooth muscle cell migration; and response to estradiol. Located in cell surface and extracellular space. Biomarker of disseminated intravascular coagulation; hypertension; and myocardial infarction. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; COVID-19; disseminated intravascular coagulation; and von Willebrand's disease. Orthologous to human F3 (coagulation factor III, tissue factor); PARTICIPATES IN acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics pathway; INTERACTS WITH (S)-colchicine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: coagulation factor 3; coagulation factor III; Coagulation factor III (thromboplastin tissue factor); coagulation factor III (thromboplastin, tissue factor); MGC93621; TF; tissue factor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82212,511,675 - 212,523,375 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2212,511,680 - 212,523,369 (+)EnsemblGRCr8
mRatBN7.22209,827,061 - 209,838,666 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2209,826,959 - 209,838,668 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2217,490,132 - 217,501,670 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02215,397,871 - 215,409,409 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02210,239,702 - 210,251,242 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02225,310,686 - 225,322,281 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2225,310,624 - 225,322,272 (+)Ensemblrn6Rnor6.0
Rnor_5.02243,348,430 - 243,360,439 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42218,371,050 - 218,382,645 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2202,257,415 - 202,269,039 (+)NCBICelera
RGSC_v3.12218,334,111 - 218,345,706 (+)NCBI
Cytogenetic Map2q42NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
Acute Lung Injury  (IEP)
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
acute pancreatitis  (ISO)
acute promyelocytic leukemia  (ISO)
adult respiratory distress syndrome  (ISO)
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis  (ISO)
B-lymphoblastic leukemia/lymphoma  (ISO)
bile duct disease  (ISO)
Breast Neoplasms  (ISO)
Cardiac Allograft Vasculopathy  (IEP)
Cardiac Fibrosis  (ISO)
carotid artery thrombosis  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
COVID-19  (ISO)
diabetes mellitus  (ISO)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
disseminated intravascular coagulation  (IEP,ISO)
Embolism and Thrombosis  (ISO)
Endotoxemia  (IDA,ISO)
Experimental Diabetes Mellitus  (ISO)
familial hyperlipidemia  (ISO)
graft-versus-host disease  (ISO)
Hemorrhage  (ISO)
hypertension  (IEP)
idiopathic pulmonary fibrosis  (ISO)
Inflammation  (IEP)
Kidney Reperfusion Injury  (IEP)
liver cirrhosis  (ISO)
Liver Injury  (ISO)
Liver Reperfusion Injury  (IMP)
Metabolic Syndrome  (ISO)
myeloid neoplasm  (ISO)
myocardial infarction  (IEP)
Myocardial Ischemia  (ISO)
Neointima  (IEP)
nephrotic syndrome  (ISO)
ovarian hyperstimulation syndrome  (ISO)
Ovary Reperfusion Injury  (IEP)
Peritoneal Fibrosis  (IEP)
pre-eclampsia  (ISO)
preterm premature rupture of the membranes  (ISO)
Sepsis  (IEP,ISO)
sickle cell anemia  (ISO)
Snake Bites  (IEP)
Spontaneous Abortions  (ISO)
Spontaneous Coronary Artery Dissection  (ISO)
Systemic Inflammatory Response Syndrome  (ISO)
Thromboembolism  (ISO)
thrombophilia  (ISO)
thrombosis  (ISO)
Thrombotic Microangiopathies  (ISO)
thrombotic thrombocytopenic purpura  (ISO)
type 2 diabetes mellitus  (ISO)
Venous Thrombosis  (ISO)
Viral Myocarditis  (ISO)
von Willebrand's disease  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(R)-noradrenaline  (ISO)
(S)-colchicine  (EXP)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-benzothiazole-2-thiol  (ISO)
1,4-dithiothreitol  (ISO)
1-naphthyl isothiocyanate  (ISO)
1-nitropyrene  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
abiraterone  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
AM-251  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP,ISO)
anandamide  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
barium chloride  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
Bryostatin  (ISO)
bryostatin 1  (ISO)
bryostatin 2  (ISO)
butan-1-ol  (ISO)
cadmium dichloride  (EXP,ISO)
calciol  (ISO)
cangrelor  (ISO)
cannabidiol  (ISO)
capsazepine  (ISO)
carbon nanotube  (ISO)
carmustine  (EXP)
carvedilol  (EXP)
CGP 52608  (ISO)
chloropicrin  (ISO)
chloroprene  (EXP)
chlorphenamine  (ISO)
chromium(6+)  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (EXP)
clomiphene  (ISO)
clopidogrel  (ISO)
cobalt dichloride  (ISO)
concanamycin A  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
crizotinib  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cypermethrin  (ISO)
cytochalasin D  (ISO)
D-glucose  (ISO)
daunorubicin  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
desloratadine  (ISO)
dexamethasone  (EXP,ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenziodolium  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
diphenhydramine  (ISO)
diuron  (EXP)
dobutamine  (ISO)
donepezil hydrochloride  (ISO)
dopamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
edaravone  (EXP)
enalapril  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
etonogestrel  (EXP)
etoposide  (ISO)
everolimus  (ISO)
fenamidone  (ISO)
ferric ammonium citrate  (ISO)
ferroheme b  (ISO)
fluoranthene  (ISO)
fluorometholone  (ISO)
fluvastatin  (ISO)
folic acid  (ISO)
fructose  (ISO)
furan  (EXP)
gentamycin  (EXP)
geranylgeraniol  (ISO)
glucose  (ISO)
glutathione  (ISO)
glycidyl methacrylate  (ISO)
glyphosate  (ISO)
heme b  (ISO)
Hexadimethrine bromide  (EXP)
hinokiflavone  (ISO)
histamine  (ISO)
histamine phosphate  (ISO)
ibuprofen  (ISO)
indole-3-acetic acid  (ISO)
indometacin  (ISO)
irbesartan  (EXP)
isobutanol  (ISO)
ketoconazole  (ISO)
L-1,4-dithiothreitol  (ISO)
L-ascorbic acid  (ISO)
lead diacetate  (ISO)
lenalidomide  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium chloride  (ISO)
losartan  (ISO)
LY294002  (ISO)
malathion  (ISO)
mancozeb  (ISO)
medroxyprogesterone acetate  (EXP,ISO)
mepyramine  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (ISO)
methamphetamine  (ISO)
Methanandamide  (ISO)
methotrexate  (EXP,ISO)
methylmercury chloride  (ISO)
mevalonic acid  (ISO)
mifamurtide  (ISO)
mifepristone  (EXP,ISO)
mithramycin  (ISO)
MK-2206  (ISO)
mometasone furoate  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
Monobutylphthalate  (ISO)
monocrotaline  (ISO)
N-acetyl-L-cysteine  (ISO)
N-acetylsphingosine  (ISO)
N-ethylmaleimide  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N-nitrosourea  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
naphthalene  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nicotinamide  (ISO)
nicotine  (ISO)
nimesulide  (ISO)
nitrofen  (EXP)
notoginsenoside R1  (ISO)
ochratoxin A  (EXP,ISO)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
paclitaxel  (ISO)
palbociclib  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosgene  (ISO)
pirinixic acid  (ISO)
primaquine  (ISO)
primidone  (ISO)
probucol  (ISO)
progesterone  (EXP,ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
quercitrin  (ISO)
quinolin-8-ol  (ISO)
ranitidine  (EXP)
resveratrol  (ISO)
riddelliine  (EXP)
rivaroxaban  (EXP)
Rutecarpine  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sirtinol  (ISO)
sodium arsenite  (ISO)
splitomicin  (ISO)
staurosporine  (ISO)
streptozocin  (EXP)
succimer  (ISO)
Sudan I  (ISO)
sulfasalazine  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
Temsirolimus  (ISO)
terconazole  (ISO)
tetrachloromethane  (EXP,ISO)
Theaflavin 3,3'-digallate  (ISO)
thioacetamide  (EXP)
tibolone  (ISO)
tin(II) chloride (anhydrous)  (ISO)
tioguanine  (EXP)
titanium dioxide  (ISO)
torin 1  (ISO)
trans-caffeic acid  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triptonide  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vincaleukoblastine  (EXP)
vinclozolin  (EXP)
vincristine  (EXP,ISO)
vitamin E  (ISO)
WIN 55212-2  (ISO)
wortmannin  (ISO)
XL147  (ISO)
zoledronic acid  (ISO)
zotarolimus  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Tissue factor activity in leukemia cells. Special reference to disseminated intravascular coagulation. Andoh K, etal., Cancer. 1987 Feb 15;59(4):748-54.
2. Viral myocarditis and coagulopathy: increased tissue factor expression and plasma thrombogenicity. Antoniak S, etal., J Mol Cell Cardiol. 2008 Jul;45(1):118-26. doi: 10.1016/j.yjmcc.2008.03.013. Epub 2008 Mar 29.
3. Tissue factor gene expression in acute myeloblastic leukemia. Bauer KA, etal., Thromb Res. 1989 Nov 1;56(3):425-30.
4. Cyclic mechanical strain alters tissue-factor activity in rat osteosarcoma cells cultured on a titanium substrate. Bledsoe JG, etal., J Biomed Mater Res A. 2004 Sep 1;70(3):490-6.
5. Circulating tissue factor procoagulant activity and thrombin generation in patients with type 2 diabetes: effects of insulin and glucose. Boden G, etal., J Clin Endocrinol Metab. 2007 Nov;92(11):4352-8. Epub 2007 Sep 4.
6. Fatal embryonic bleeding events in mice lacking tissue factor, the cell-associated initiator of blood coagulation. Bugge TH, etal., Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6258-63.
7. An accompanying genetic severe deficiency of tissue factor protects mice with a protein C deficiency from lethal endotoxemia. Castellino FJ, etal., Blood. 2011 Jan 6;117(1):283-9. doi: 10.1182/blood-2010-07-299057. Epub 2010 Sep 21.
8. Thrombosis in primary antiphospholipid syndrome: a pivotal role for monocyte tissue factor expression. Cuadrado MJ, etal., Arthritis Rheum. 1997 May;40(5):834-41.
9. Prevention of endotoxin-induced mortality by antitissue factor immunization. Dackiw AP, etal., Arch Surg. 1996 Dec;131(12):1273-8; discussion 1278-9.
10. Elevated numbers of tissue-factor exposing microparticles correlate with components of the metabolic syndrome in uncomplicated type 2 diabetes mellitus. Diamant M, etal., Circulation. 2002 Nov 5;106(19):2442-7.
11. Induction of monocytic tissue factor expression after rewarming from hypothermia in vivo is counteracted by heat shock in c-Jun-dependent manner. Egorina EM, etal., Arterioscler Thromb Vasc Biol. 2006 Oct;26(10):2401-6. Epub 2006 Aug 10.
12. A link between a hemostatic disorder and preterm PROM: a role for tissue factor and tissue factor pathway inhibitor. Erez O, etal., J Matern Fetal Neonatal Med. 2008 Oct;21(10):732-44. doi: 10.1080/14767050802361807.
13. Evidence of maternal platelet activation, excessive thrombin generation, and high amniotic fluid tissue factor immunoreactivity and functional activity in patients with fetal death. Erez O, etal., J Matern Fetal Neonatal Med. 2009 Aug;22(8):672-87. doi: 10.1080/14767050902853117.
14. Relevance of tissue factor and tissue factor pathway inhibitor for hypercoagulable state in the lungs of patients with idiopathic pulmonary fibrosis. Fujii M, etal., Thromb Res. 2000 Jul 15;99(2):111-7.
15. Activation of the extrinsic coagulation pathway in patients with severe sepsis and septic shock. Gando S, etal., Crit Care Med. 1998 Dec;26(12):2005-9.
16. Systemic activation of tissue-factor dependent coagulation pathway in evolving acute respiratory distress syndrome in patients with trauma and sepsis. Gando S, etal., J Trauma. 1999 Oct;47(4):719-23.
17. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
18. The expression of tissue factor and tissue factor pathway inhibitor in aortic smooth muscle cells is up-regulated in synthetic compared to contractile phenotype. Ghrib F, etal., Thromb Haemost 2002 Jun;87(6):1051-6.
19. Intimal tissue factor activity is released from the arterial wall after injury. Giesen PL, etal., Thromb Haemost. 2000 Apr;83(4):622-8.
20. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
21. Changes of tissue factor activity on inflammatory stimulus and aging in rat. Han YN and Rhee IK, Arch Pharm Res. 1998 Oct;21(5):549-54.
22. Expressions of tissue factor and tissue factor pathway inhibitor in patients with acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. Hao J, etal., J Huazhong Univ Sci Technolog Med Sci. 2009 Dec;29(6):697-700. doi: 10.1007/s11596-009-0604-4. Epub 2009 Dec 29.
23. Expression of tissue factor and tissue factor pathway inhibitor in rats lungs with lipopolysaccharide-induced disseminated intravascular coagulation. Hara S, etal., Lab Invest. 1997 Dec;77(6):581-9.
24. Tissue factor overexpression in rat arterial neointima models thrombosis and progression of advanced atherosclerosis. Hasenstab D, etal., Circulation. 2000 Jun 6;101(22):2651-7.
25. In vitro and in vivo characterisation of the profibrinolytic effect of an inhibitory anti-rat TAFI nanobody. Hendrickx ML, etal., Thromb Haemost. 2014 May 5;111(5):824-32. doi: 10.1160/TH13-08-0645. Epub 2014 Jan 9.
26. In situ detection of tissue factor within the coronary intima in rat cardiac allograft vasculopathy. Holschermann H, etal., Am J Pathol. 1999 Jan;154(1):211-20.
27. Fluid shear stress induction of the tissue factor promoter in vitro and in vivo is mediated by Egr-1. Houston P, etal., Arterioscler Thromb Vasc Biol. 1999 Feb;19(2):281-9.
28. The thrombomodulin-protein C system is essential for the maintenance of pregnancy. Isermann B, etal., Nat Med 2003 Mar;9(3):331-7.
29. Tissue factor expression in neutrophil extracellular traps and neutrophil derived microparticles in antineutrophil cytoplasmic antibody associated vasculitis may promote thromboinflammation and the thrombophilic state associated with the disease. Kambas K, etal., Ann Rheum Dis. 2014 Oct;73(10):1854-63. doi: 10.1136/annrheumdis-2013-203430. Epub 2013 Jul 19.
30. Elevated levels of leukocyte tissue factor mRNA in patients with venous thromboembolism. Kamikura Y, etal., Thromb Res. 2005;116(4):307-12. Epub 2005 Jan 28.
31. Cytoplasmic domain of tissue factor promotes liver fibrosis in mice. Knight V, etal., World J Gastroenterol. 2017 Aug 21;23(31):5692-5699. doi: 10.3748/wjg.v23.i31.5692.
32. Increased tissue factor, MMP-8, and D-dimer expression in diabetic patients with unstable advanced carotid atherosclerosis. Krupinski J, etal., Vasc Health Risk Manag. 2007;3(4):405-12.
33. In vivo anticoagulant effect of ethyl pyruvate in endotoxemic rats. Kung CW, etal., Thromb Res. 2011 Jun;127(6):582-8. Epub 2011 Mar 10.
34. Increased plasma level of asymmetric dimethylarginine in hypertensive rats facilitates platelet aggregation: role of plasma tissue factor. Li D, etal., Can J Physiol Pharmacol. 2011 Mar;89(3):151-8. doi: 10.1139/Y10-115.
35. The role of tissue factor in renal ischemic reperfusion injury by antisense oligodeoxynucleotide. Matsuyama M, etal., Transplant Proc 2002 Aug;34(5):1475-6.
36. Inhibition of tissue factor expression by hydroxyurea in polymorphonuclear leukocytes from patients with myeloproliferative disorders: a new effect for an old drug? Maugeri N, etal., J Thromb Haemost. 2006 Dec;4(12):2593-8. Epub 2006 Sep 6.
37. [Expression of fusion protein encoding EGFP-EGF1 of rat coagulation factor VII and its binding function] May H, etal., Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2008 Feb;16(1):181-4.
38. Thrombophilia in mice expressing a tissue factor variant lacking its transmembrane and cytosolic domain. Melis E, etal., Biochem Biophys Res Commun. 2005 Jul 29;333(2):488-95.
39. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
40. Plasma levels of tissue factor and soluble E-selectin in sickle cell disease: relationship to genotype and to inflammation. Mohan JS, etal., Blood Coagul Fibrinolysis. 2005 Apr;16(3):209-14.
41. Inhibition of lipopolysaccharide-induced tissue factor expression in monocytes by urinary trypsin inhibitor in vitro and in vivo. Molor-Erdene P, etal., Thromb Haemost. 2005 Jul;94(1):136-45.
42. Antisense oligonucleotide for tissue factor inhibits hepatic ischemic reperfusion injury. Nakamura K, etal., Biochem Biophys Res Commun 2002 Sep 27;297(3):433-41.
43. Effect of antisense oligonucleotides for tissue factor on hepatic ischemia-reperfusion injury in the rat. Nakamura K, etal., Transplant Proc. 2001 Nov-Dec;33(7-8):3707-8.
44. Elevated tissue factor levels in leukemic cell homogenate. Nakasaki T, etal., Clin Appl Thromb Hemost. 2000 Jan;6(1):14-7.
45. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
46. Blood coagulation. Norris LA, Best Pract Res Clin Obstet Gynaecol. 2003 Jun;17(3):369-83.
47. Investigation for role of tissue factor and blood coagulation system in severe acute pancreatitis and associated liver injury. Ou ZB, etal., Biomed Pharmacother. 2017 Jan;85:380-388. doi: 10.1016/j.biopha.2016.11.039. Epub 2016 Dec 4.
48. The protective effects of prostaglandin E1 on lung injury following renal ischemia-reperfusion in rats. Oztay F, etal., Toxicol Ind Health. 2015 Apr 16. pii: 0748233715576615.
49. Peroxisome proliferator-activated receptor-gamma agonists suppress tissue factor overexpression in rat balloon injury model with paclitaxel infusion. Park JB, etal., PLoS One. 2011;6(11):e28327. doi: 10.1371/journal.pone.0028327. Epub 2011 Nov 29.
50. Tissue factor deficiency causes cardiac fibrosis and left ventricular dysfunction. Pawlinski R, etal., Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15333-8. Epub 2002 Nov 8.
51. LDL increases inactive tissue factor on vascular smooth muscle cell surfaces: hydrogen peroxide activates latent cell surface tissue factor. Penn MS, etal., Circulation. 1999 Apr 6;99(13):1753-9.
52. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
53. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
54. Urinary procoagulant activity and tissue factor levels in patients with diabetes mellitus. Qi H, etal., Haemostasis. 1997 Mar-Apr;27(2):57-64.
55. Immune complement and coagulation dysfunction in adverse outcomes of SARS-CoV-2 infection. Ramlall V, etal., Nat Med. 2020 Aug 3. pii: 10.1038/s41591-020-1021-2. doi: 10.1038/s41591-020-1021-2.
56. Airway tissue factor-dependent coagulation activity in response to sulfur mustard analog 2-chloroethyl ethyl sulfide. Rancourt RC, etal., Am J Physiol Lung Cell Mol Physiol. 2012 Jan 1;302(1):L82-92. doi: 10.1152/ajplung.00306.2010. Epub 2011 Sep 30.
57. GOA pipeline RGD automated data pipeline
58. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
59. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
60. Hypercoagulability, high tissue factor and low tissue factor pathway inhibitor levels in severe ovarian hyperstimulation syndrome: possible association with clinical outcome. Rogolino A, etal., Blood Coagul Fibrinolysis. 2003 Apr;14(3):277-82.
61. Tissue factor and factor v involvement in rat peritoneal fibrosis. Saito H, etal., Perit Dial Int. 2009 May-Jun;29(3):340-51.
62. Analysis of behaviors of plasma tissue factor and tissue factor pathway inhibitor in patients with various diseases Saito M, etal., Rinsho Ketsueki. 1996 Sep;37(9):794-8.
63. Enhanced expression of monocyte tissue factor in patients with liver cirrhosis. Saliola M, etal., Gut. 1998 Sep;43(3):428-32. doi: 10.1136/gut.43.3.428.
64. Increased levels of tissue factor activity and procoagulant phospholipids during treatment of children with acute lymphoblastic leukaemia. Schneider P, etal., Br J Haematol. 2010 Feb;148(4):582-92. doi: 10.1111/j.1365-2141.2009.07958.x. Epub 2009 Oct 28.
65. Role of tissue factor in a mouse model of thrombotic microangiopathy induced by antiphospholipid antibodies. Seshan SV, etal., Blood. 2009 Aug 20;114(8):1675-83. doi: 10.1182/blood-2009-01-199117. Epub 2009 Jun 17.
66. How it all starts: Initiation of the clotting cascade. Smith SA, etal., Crit Rev Biochem Mol Biol. 2015;50(4):326-36. doi: 10.3109/10409238.2015.1050550. Epub 2015 May 28.
67. Soluble tissue factor is a candidate marker for progression of microvascular disease in patients with Type 2 diabetes. Sommeijer DW, etal., J Thromb Haemost. 2006 Mar;4(3):574-80. Epub 2005 Dec 22.
68. Renal tissue factor expression is increased in streptozotocin-induced diabetic mice. Sommeijer DW, etal., Nephron Exp Nephrol. 2005;101(3):e86-94. Epub 2005 Jun 30.
69. Plasma levels of tissue factor antigen in patients with non-insulin-dependent diabetes mellitus. Song KS and Kim HK, Yonsei Med J. 2004 Feb 29;45(1):38-42.
70. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
71. The coagulation system contributes to alphaVbeta6 integrin expression and liver fibrosis induced by cholestasis. Sullivan BP, etal., Am J Pathol. 2010 Dec;177(6):2837-49. doi: 10.2353/ajpath.2010.100425. Epub 2010 Oct 29.
72. Cloning of the rat tissue factor cDNA and promoter: identification of a serum-response region. Taby O, etal., Thromb Haemost 1996 Nov;76(5):697-702.
73. The expression of tissue factor antigen and activity on the surface of leukemic cells. Tanaka M and Yamanishi H, Leuk Res. 1993 Feb;17(2):103-11.
74. Tissue factor and thrombin in posttraumatic systemic inflammatory response syndrome. Taylor FB Jr Crit Care Med. 1997 Nov;25(11):1774-5.
75. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
76. Effect of tissue factor deficiency on mouse and tumor development. Toomey JR, etal., Proc Natl Acad Sci U S A 1997 Jun 24;94(13):6922-6.
77. The effects of tacrolimus on the activity and expression of tissue factor in the rat ovary with ischemia-reperfusion induced injury. Ustundag UV, etal., Reprod Biol. 2015 Sep;15(3):139-45. doi: 10.1016/j.repbio.2015.07.002. Epub 2015 Jul 26.
78. Recombinant human factor VIIa-induced alterations in tissue factor and thrombomodulin in patients with advanced liver cirrhosis. Van Thiel DH, etal., J Gastroenterol Hepatol. 2005 Jun;20(6):882-9. doi: 10.1111/j.1440-1746.2005.03761.x.
79. Systemic changes following carrageenan-induced paw inflammation in rats. Vazquez E, etal., Inflamm Res. 2015 May;64(5):333-42. doi: 10.1007/s00011-015-0814-0. Epub 2015 Mar 15.
80. Clinical features and treatment of COVID-19 patients in northeast Chongqing. Wan S, etal., J Med Virol. 2020 Jul;92(7):797-806. doi: 10.1002/jmv.25783. Epub 2020 Apr 1.
81. Effects of 17beta-estradiol and phytoestrogen alpha-zearalanol on tissue factor in plasma of ovariectomized rats and HUVECs. Wang W, etal., Chin J Physiol. 2004 Jun 30;47(2):67-72.
82. Bothrops jararaca venom metalloproteinases are essential for coagulopathy and increase plasma tissue factor levels during envenomation. Yamashita KM, etal., PLoS Negl Trop Dis. 2014 May 15;8(5):e2814. doi: 10.1371/journal.pntd.0002814. eCollection 2014 May.
83. Combined effects of irbesartan and carvedilol on expression of tissue factor and tissue factor pathway inhibitor in rats after myocardial infarction. Yu J, etal., Heart Vessels. 2011 Nov;26(6):646-53. doi: 10.1007/s00380-010-0106-0. Epub 2011 Jan 13.
84. Reduced tissue factor (thromboplastin) activity in von Willebrand's disease. Zacharski LR, etal., Am J Med. 1974 Jul;57(1):102-7.
85. Sodium tanshinone II a sulfonate ameliorates microcirculatory disturbance of small intestine by attenuating the production of reactie oxygen species in rats with sepsis. Zhu W, etal., Chin J Integr Med. 2015 Aug 26.
86. Tissue factor antigen is elevated in patients with microvascular complications of diabetes mellitus. Zumbach M, etal., Exp Clin Endocrinol Diabetes. 1997;105(4):206-12.
Additional References at PubMed
PMID:2704749   PMID:3455766   PMID:8632006   PMID:12362240   PMID:12958621   PMID:17469850   PMID:17586694   PMID:17595667   PMID:17898544   PMID:17991872   PMID:18612547   PMID:18621373  
PMID:19062044   PMID:19065458   PMID:19265029   PMID:19439347   PMID:19581412   PMID:19734584   PMID:21814178   PMID:22556343   PMID:22647506   PMID:23376485   PMID:24998411   PMID:27542118  
PMID:28738734   PMID:30449218   PMID:30840287   PMID:33794911   PMID:38943142  


Genomics

Comparative Map Data
F3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82212,511,675 - 212,523,375 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2212,511,680 - 212,523,369 (+)EnsemblGRCr8
mRatBN7.22209,827,061 - 209,838,666 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2209,826,959 - 209,838,668 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2217,490,132 - 217,501,670 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02215,397,871 - 215,409,409 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02210,239,702 - 210,251,242 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02225,310,686 - 225,322,281 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2225,310,624 - 225,322,272 (+)Ensemblrn6Rnor6.0
Rnor_5.02243,348,430 - 243,360,439 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42218,371,050 - 218,382,645 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2202,257,415 - 202,269,039 (+)NCBICelera
RGSC_v3.12218,334,111 - 218,345,706 (+)NCBI
Cytogenetic Map2q42NCBI
F3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38194,529,173 - 94,541,759 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl194,529,173 - 94,541,759 (-)Ensemblhg38GRCh38
GRCh37194,994,729 - 95,007,315 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36194,767,461 - 94,779,903 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34194,706,893 - 94,719,336NCBI
Celera193,249,195 - 93,261,871 (-)NCBICelera
Cytogenetic Map1p21.3NCBI
HuRef193,116,432 - 93,129,108 (-)NCBIHuRef
CHM1_1195,109,584 - 95,122,259 (-)NCBICHM1_1
T2T-CHM13v2.0194,377,216 - 94,389,797 (-)NCBIT2T-CHM13v2.0
F3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393121,517,186 - 121,528,701 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3121,517,186 - 121,528,697 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm383121,723,537 - 121,735,052 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3121,723,537 - 121,735,048 (+)Ensemblmm10GRCm38
MGSCv373121,426,455 - 121,437,970 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv363121,715,560 - 121,727,066 (+)NCBIMGSCv36mm8
Celera3128,097,400 - 128,112,071 (+)NCBICelera
Cytogenetic Map3G1NCBI
cM Map352.94NCBI
F3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955423254,189 - 264,159 (+)Ensembl
ChiLan1.0NW_004955423254,060 - 264,448 (+)NCBIChiLan1.0ChiLan1.0
F3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21132,482,788 - 132,495,423 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11131,637,687 - 131,650,209 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0197,190,381 - 97,203,076 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1195,918,359 - 95,931,050 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl195,918,502 - 95,931,050 (-)EnsemblpanPan2panpan1.1
F3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1654,709,581 - 54,720,603 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl654,708,471 - 54,720,607 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha657,418,032 - 57,428,969 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0655,085,266 - 55,096,260 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl655,083,526 - 55,096,264 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1654,766,195 - 54,777,118 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0654,750,367 - 54,761,295 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0655,203,270 - 55,214,213 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
F3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405058104,300,058 - 104,310,937 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365374,636,667 - 4,647,916 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365374,637,028 - 4,647,915 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
F3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4122,826,644 - 122,837,666 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.14122,827,018 - 122,837,673 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24134,474,466 - 134,479,707 (+)NCBISscrofa10.2Sscrofa10.2susScr3
F3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12038,726,690 - 38,738,457 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2038,726,798 - 38,739,408 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603379,312,870 - 79,325,353 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
F3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247423,112,801 - 3,124,301 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247423,112,827 - 3,123,424 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in F3
114 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:125
Count of miRNA genes:73
Interacting mature miRNAs:92
Transcripts:ENSRNOT00000015836
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2190613715226808892Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
1598813Memor9Memory QTL 92.7exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2199341726234244620Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
2298479Eau5Experimental allergic uveoretinitis QTL 50.0021uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)2202446871237938339Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
61458Bp10Blood pressure QTL 103.42arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2184165752229165752Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189599258234599258Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2193452645245889826Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2189599258226936289Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2185876309219753474Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2179946951224946951Rat
631203Gluco14Glucose level QTL 140.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)2206665645219003804Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2200990457245990457Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
1298083Bp158Blood pressure QTL 1582.62arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1331745Bp203Blood pressure QTL 2034.377arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2189599258218414891Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2189599258234599258Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
2299161Iddm33Insulin dependent diabetes mellitus QTL 332.98blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2206312063220876787Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2179335906224335906Rat
2293084Iddm26Insulin dependent diabetes mellitus QTL 262.9blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2174930955213594495Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat

Markers in Region
RH94643  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr82212,522,857 - 212,523,048 (+)Marker Load Pipeline
mRatBN7.22209,838,148 - 209,838,339 (+)MAPPERmRatBN7.2
Rnor_6.02225,321,764 - 225,321,954NCBIRnor6.0
Rnor_5.02243,359,922 - 243,360,112UniSTSRnor5.0
RGSC_v3.42218,382,128 - 218,382,318UniSTSRGSC3.4
Celera2202,268,522 - 202,268,712UniSTS
Cytogenetic Map2q41UniSTS
RH135388  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22209,837,999 - 209,838,212 (+)MAPPERmRatBN7.2
Rnor_6.02225,321,615 - 225,321,827NCBIRnor6.0
Rnor_5.02243,359,773 - 243,359,985UniSTSRnor5.0
RGSC_v3.42218,381,979 - 218,382,191UniSTSRGSC3.4
Celera2202,268,373 - 202,268,585UniSTS
RH 3.4 Map21502.8UniSTS
Cytogenetic Map2q41UniSTS
RH141859  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22209,826,035 - 209,826,244 (+)MAPPERmRatBN7.2
Rnor_6.02225,309,661 - 225,309,869NCBIRnor6.0
Rnor_5.02243,347,014 - 243,347,222UniSTSRnor5.0
RGSC_v3.42218,370,025 - 218,370,233UniSTSRGSC3.4
Celera2202,256,390 - 202,256,598UniSTS
RH 3.4 Map21503.0UniSTS
Cytogenetic Map2q41UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 41 59 6 305 141 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000015836   ⟹   ENSRNOP00000015836
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2212,511,680 - 212,523,369 (+)Ensembl
mRatBN7.2 Ensembl2209,827,130 - 209,838,668 (+)Ensembl
Rnor_6.0 Ensembl2225,310,624 - 225,322,272 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114365   ⟹   ENSRNOP00000077841
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2212,512,809 - 212,522,095 (+)Ensembl
mRatBN7.2 Ensembl2209,826,959 - 209,837,017 (+)Ensembl
RefSeq Acc Id: NM_013057   ⟹   NP_037189
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82212,511,772 - 212,523,375 (+)NCBI
mRatBN7.22209,827,061 - 209,838,666 (+)NCBI
Rnor_6.02225,310,686 - 225,322,281 (+)NCBI
Rnor_5.02243,348,430 - 243,360,439 (+)NCBI
RGSC_v3.42218,371,050 - 218,382,645 (+)RGD
Celera2202,257,415 - 202,269,039 (+)RGD
Sequence:
RefSeq Acc Id: XM_039101800   ⟹   XP_038957728
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82212,511,756 - 212,523,375 (+)NCBI
mRatBN7.22209,827,797 - 209,838,666 (+)NCBI
RefSeq Acc Id: XM_063281370   ⟹   XP_063137440
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82212,511,675 - 212,523,375 (+)NCBI
RefSeq Acc Id: XM_063281371   ⟹   XP_063137441
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82212,511,985 - 212,523,375 (+)NCBI
RefSeq Acc Id: NP_037189   ⟸   NM_013057
- Peptide Label: precursor
- UniProtKB: P42533 (UniProtKB/Swiss-Prot),   Q66HI4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000015836   ⟸   ENSRNOT00000015836
RefSeq Acc Id: XP_038957728   ⟸   XM_039101800
- Peptide Label: isoform X3
- UniProtKB: F7EW83 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000077841   ⟸   ENSRNOT00000114365
RefSeq Acc Id: XP_063137440   ⟸   XM_063281370
- Peptide Label: isoform X1
- UniProtKB: P42533 (UniProtKB/Swiss-Prot),   A0A8I5ZJL3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137441   ⟸   XM_063281371
- Peptide Label: isoform X2
Protein Domains
Fibronectin type-III   Interferon/interleukin receptor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P42533-F1-model_v2 AlphaFold P42533 1-295 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691719
Promoter ID:EPDNEW_R2244
Type:multiple initiation site
Name:F3_1
Description:coagulation factor III, tissue factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02225,310,676 - 225,310,736EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2587 AgrOrtholog
BioCyc Gene G2FUF-51391 BioCyc
Ensembl Genes ENSRNOG00000011800 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000015836 ENTREZGENE
  ENSRNOT00000114365 ENTREZGENE
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7096602 IMAGE-MGC_LOAD
InterPro FN3_dom UniProtKB/Swiss-Prot
  FN3_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Interferon/interleukin_rcp_dom UniProtKB/Swiss-Prot
  Tissue_factor UniProtKB/Swiss-Prot
  Tissue_Factor_CS UniProtKB/Swiss-Prot
  Type-II_Cytokine-TF_Rcpt UniProtKB/Swiss-Prot
MGC_CLONE MGC:93621 IMAGE-MGC_LOAD
NCBI Gene 25584 ENTREZGENE
PANTHER INTERFERON/INTERLEUKIN RECEPTOR UniProtKB/Swiss-Prot
  PTHR20859:SF22 UniProtKB/Swiss-Prot
Pfam Interfer-bind UniProtKB/Swiss-Prot
  Tissue_fac UniProtKB/Swiss-Prot
PhenoGen F3 PhenoGen
PIRSF Tissue_factor_3 UniProtKB/Swiss-Prot
PRINTS TISSUEFACTOR UniProtKB/Swiss-Prot
PROSITE TISSUE_FACTOR UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011800 RatGTEx
Superfamily-SCOP SSF49265 UniProtKB/Swiss-Prot
TIGR TC235743
UniProt A0A8I5ZJL3 ENTREZGENE, UniProtKB/TrEMBL
  A6HVF0_RAT UniProtKB/TrEMBL
  A6HVF1_RAT UniProtKB/TrEMBL
  F7EW83 ENTREZGENE, UniProtKB/TrEMBL
  P42533 ENTREZGENE
  Q66HI4 ENTREZGENE, UniProtKB/TrEMBL
  TF_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-20 F3  coagulation factor III, tissue factor  F3  coagulation factor III (thromboplastin, tissue factor)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-09 F3  coagulation factor III (thromboplastin, tissue factor)  F3  coagulation factor III  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 F3  coagulation factor III      Name updated 1299863 APPROVED
2003-04-09 F3  coagulation factor 3     Coagulation factor III (thromboplastin, tissue factor)  Name updated 629478 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process mediates hepatic ischemic reperfusion injury 632791