Esr2 (estrogen receptor 2) - Rat Genome Database

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Gene: Esr2 (estrogen receptor 2) Rattus norvegicus
Symbol: Esr2
Name: estrogen receptor 2
RGD ID: 2582
Description: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; estrogen binding activity; and steroid binding activity. Involved in several processes, including brain development; cellular response to lipid; and reproductive structure development. Located in mitochondrion; perikaryon; and perinuclear region of cytoplasm. Part of protein-DNA complex. Used to study several diseases, including hypertension (multiple); obesity; peritonitis; prostate carcinoma in situ; and transient cerebral ischemia. Biomarker of asthma; brain ischemia; colitis; cystitis; and osteoporosis. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); bone disease (multiple); hypospadias; and neurodegenerative disease (multiple). Orthologous to human ESR2 (estrogen receptor 2); PARTICIPATES IN estrogen signaling pathway; bisphenol A response pathway; tamoxifen pharmacodynamics pathway; INTERACTS WITH (R,R,R)-alpha-tocopherol; (S)-naringenin; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ER-beta; Erb2; ERbeta; estrogen receptor 2 (beta); estrogen receptor 2 (ER beta); estrogen receptor 2 beta; estrogen receptor beta; nuclear receptor subfamily 3 group A member 2
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Esr2em1Soar  
Genetic Models: SD-Esr2em1Soar
Candidate Gene For: Schws8
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2694,858,438 - 94,909,630 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl694,809,547 - 94,908,919 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx695,252,364 - 95,302,093 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0695,550,861 - 95,600,589 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0694,979,673 - 95,029,407 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0699,163,953 - 99,214,711 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl699,164,357 - 99,214,251 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06108,576,398 - 108,626,196 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4698,691,167 - 98,775,299 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1698,694,622 - 98,778,755 (-)NCBI
Celera693,284,596 - 93,334,744 (-)NCBICelera
RH 3.4 Map6686.1RGD
Cytogenetic Map6q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
adenocarcinoma  (ISO)
adenoma  (ISO)
alopecia  (ISO)
Alzheimer's disease  (ISO)
Animal Mammary Neoplasms  (ISO)
anxiety disorder  (IDA)
aortic valve stenosis  (ISO)
asthma  (IEP)
atherosclerosis  (ISO)
atrial fibrillation  (ISO)
Blast Crisis  (ISO)
brain ischemia  (IEP)
breast cancer  (IDA,ISO)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
Cardiac Arrhythmias  (ISO)
Cocaine-Related Disorders  (ISO)
Cognitive Dysfunction  (ISO)
colitis  (IEP,ISO)
colon cancer  (IDA)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
contact dermatitis  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
Crohn's disease  (ISO)
cystitis  (IEP)
Deafness  (ISO)
depressive disorder  (IDA)
Endometrial Neoplasms  (ISO)
endometriosis  (ISO)
Experimental Arthritis  (IDA)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Mammary Neoplasms  (IDA,IEP,ISO)
Experimental Melanoma  (ISO)
Female Infertility  (IMP,ISO)
genetic disease  (ISO)
glomerulosclerosis  (ISO)
Graves' disease  (ISO)
Hand Osteoarthritis  (ISO)
Hashimoto Disease  (ISO)
Hearing Loss  (ISO)
Hemorrhagic Shock  (IDA)
Hot Flashes  (IDA)
Hyperalgesia  (IDA,ISO)
hypertension  (IMP,ISO)
hypospadias  (ISO)
in situ carcinoma  (ISO)
inflammatory bowel disease  (IDA)
interstitial cystitis  (ISO)
Knee Osteoarthritis  (ISO)
Left Ventricular Hypertrophy  (ISO)
Lithiasis  (ISO)
Lung Injury  (IDA)
malignant astrocytoma  (ISO)
medulloblastoma  (ISO)
melanoma  (ISO)
myasthenia gravis  (ISO)
myeloid leukemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplastic Cell Transformation  (ISO)
obesity  (IDA)
osteoarthritis  (ISO)
osteoporosis  (IEP,ISO)
Osteoporotic Fractures  (IEP,ISO)
ovarian dysgenesis 8  (ISO)
Parkinson's disease  (ISO)
peritonitis  (IDA)
Pituitary Neoplasms  (ISO)
Postmenopausal Osteoporosis  (ISO)
pre-eclampsia  (ISO)
primary open angle glaucoma  (ISO)
prostate cancer  (ISO)
prostate carcinoma in situ  (IDA,ISO)
prostatic hypertrophy  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary hypertension  (IDA)
retinal degeneration  (ISO)
rheumatoid arthritis  (ISO)
Sepsis  (IDA)
Spinal Cord Injuries  (IEP)
Splenomegaly  (ISO)
Stroke  (IDA)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
transient cerebral ischemia  (IMP)
transitional cell carcinoma  (ISO)
ulcerative colitis  (ISO)
urinary bladder cancer  (ISO)
Urination Disorders  (IDA)
Varicose Ulcer  (ISO)
Vulvar Lichen Sclerosus  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(24S)-24-hydroxycholesterol  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(3-phenoxyphenyl)methanol  (ISO)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-naringenin  (EXP,ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP,ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
1-bromopropane  (ISO)
1-Hydroxypyrene  (ISO)
1-naphthol  (ISO)
10H-phenothiazine  (ISO)
16-Ketoestrone  (ISO)
17alpha-estradiol  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17alpha-hydroxyprogesterone  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2'-Bisphenol F  (ISO)
2,2'-Dihydroxy-4-methoxybenzophenone  (ISO)
2,2,2-trichloroethanol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,4,5-Tetrachloro-4'-biphenylol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-bis(4-hydroxyphenyl)propionitrile  (EXP,ISO)
2,4,5-trichlorophenol  (ISO)
2,4,6-Trimethylbenzaldehyde  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2,4-dichlorophenol  (ISO)
2,4-Dihydroxybenzophenone  (ISO)
2,6-diisopropylnaphthalene  (ISO)
2,6-dimethylnaphthalene  (ISO)
2-benzyl-4-chlorophenol  (ISO)
2-hydroxy-17beta-estradiol  (EXP,ISO)
2-hydroxyestrone  (ISO)
2-tert-butylhydroquinone  (ISO)
2-tert-Butylphenol  (ISO)
22-Hydroxycholesterol  (ISO)
25-hydroxycholesterol  (ISO)
26-hydroxycholesterol  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,3'-diindolylmethane  (ISO)
3,3'-Dimethylbenzidine  (ISO)
3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol  (ISO)
3,5,6-trichloro-2-pyridinol  (ISO)
3,5,6-trichloropyridine-2-one  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-Methyl-4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3-buten-2-one  (ISO)
3-phenoxybenzoic acid  (ISO)
4'-epidoxorubicin  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4,4'-thiodiphenol  (ISO)
4-Androstenediol  (EXP)
4-chloro-3,5-dimethylphenol  (ISO)
4-ethylphenol  (ISO)
4-hydroxy-17beta-estradiol  (EXP,ISO)
4-Hydroxybenzophenone  (ISO)
4-nitro-m-cresol  (ISO)
4-nitrophenol  (EXP)
4-nitrotoluene  (ISO)
4-nonylphenol  (ISO)
4-octylphenol  (ISO)
4-Propylphenol  (ISO)
4-tert-butylphenol  (ISO)
4-tert-Octylphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5alpha-androstane-3alpha,17beta-diol  (EXP)
5alpha-androstane-3beta,17beta-diol  (EXP)
6-oxocampestanol  (ISO)
7,12-dimethyltetraphene  (EXP,ISO)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (ISO)
9-phenanthrol  (ISO)
acetochlor  (ISO)
acetophenone  (ISO)
acrylamide  (ISO)
adenosine  (ISO)
afimoxifene  (EXP,ISO)
aldehydo-D-glucose  (ISO)
aldrin  (ISO)
all-trans-phytoene  (ISO)
all-trans-phytofluene  (ISO)
all-trans-retinoic acid  (ISO)
alpha-hexachlorocyclohexane  (ISO)
alpha-naphthoflavone  (EXP)
alpha-Zearalanol  (EXP,ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
ammonium chloride  (EXP)
androgen antagonist  (EXP)
androst-4-ene-3,17-dione  (ISO)
androst-5-ene-3beta,17beta-diol  (EXP,ISO)
androstane-3,17-diol  (EXP,ISO)
anilines  (ISO)
apigenin  (ISO)
Aroclor 1254  (EXP,ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP,ISO)
azadirachtin A  (ISO)
bazedoxifene  (ISO)
benzo[a]pyrene  (ISO)
benzophenone  (ISO)
benzyl benzoate  (ISO)
Benzyl parahydroxybenzoate  (ISO)
Benzyl salicylate  (ISO)
beta-carotene  (ISO)
beta-hexachlorocyclohexane  (ISO)
beta-naphthoflavone  (EXP)
beta-tocopherol  (EXP)
beta-Zearalanol  (EXP)
bexarotene  (EXP,ISO)
bicalutamide  (ISO)
bifenthrin  (ISO)
biochanin A  (EXP,ISO)
biphenyl-2-ol  (ISO)
biphenyl-4-ol  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
bortezomib  (ISO)
brassinolide  (ISO)
Bromofos  (ISO)
Bromophos-ethyl  (ISO)
butanal  (ISO)
butylated hydroxyanisole  (ISO)
butylbenzene  (ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (EXP,ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
camptothecin  (ISO)
captan  (ISO)
carbaryl  (ISO)
carbendazim  (EXP)
carbon nanotube  (ISO)
carfilzomib  (ISO)
cedrol  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chlorogenic acid  (EXP)
chloropropylate  (ISO)
chlorpyrifos  (ISO)
chlorpyrifos-methyl  (ISO)
chromium(6+)  (EXP)
chrysin  (ISO)
cisplatin  (ISO)
citral  (ISO)
clomiphene  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
coumaphos  (ISO)
coumestrol  (EXP,IPI,ISO)
Cuprizon  (EXP)
cyanazine  (ISO)
Cyanofenphos  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyhalothrin  (ISO)
cypermethrin  (ISO)
cyproterone acetate  (ISO)
D-aspartic acid  (ISO)
D-glucose  (ISO)
daidzein  (EXP,ISO)
daidzein 7-O-beta-D-glucoside  (EXP)
Decamethylcyclopentasiloxane  (ISO)
dehydroepiandrosterone  (EXP,ISO)
delta-hexachlorocyclohexane  (ISO)
delta-tocopherol  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
Di-n-hexyl phthalate  (ISO)
Di-n-octyl phthalate  (ISO)
diarsenic trioxide  (ISO)
diarylheptanoid  (ISO)
dibutyl phthalate  (EXP,ISO)
Dichlofenthion  (ISO)
dicofol  (ISO)
Dicyclohexyl phthalate  (ISO)
dieldrin  (ISO)
dienestrol  (EXP)
diethyl phthalate  (ISO)
diethylstilbestrol  (EXP,ISO)
digitoxin  (ISO)
diheptyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
Diisodecyl phthalate  (ISO)
dimethoate  (ISO)
diniconazole  (ISO)
dioscin  (ISO)
diosgenin  (ISO)
dioxygen  (EXP,ISO)
dipentyl phthalate  (ISO)
diphenylmethanol  (ISO)
dipropyl phthalate  (ISO)
disodium selenite  (ISO)
diuron  (ISO)
dodecylamine  (ISO)
doxorubicin  (ISO)
dronedarone  (ISO)
emetine  (ISO)
emodin  (ISO)
endosulfan  (EXP,ISO)
endrin  (ISO)
enilconazole  (ISO)
enzacamene  (EXP,ISO)
equilin  (ISO)
equol  (ISO)
estradiol  (EXP)
estriol  (EXP,ISO)
estrone  (EXP,ISO)
estrone 3-sulfate  (EXP)
ethanol  (EXP)
ethion  (ISO)
Ethyl cinnamate  (ISO)
ethyl myristate  (ISO)
ethylparaben  (EXP,ISO)
etoposide  (ISO)
eugenol  (ISO)
fenamiphos  (ISO)
fenarimol  (ISO)
fenbuconazole  (ISO)
fenhexamid  (ISO)
fenitrothion  (ISO)
fenpyroximate  (ISO)
fenthion  (ISO)
fentin chloride  (ISO)
fenvalerate  (ISO)
finasteride  (ISO)
fingolimod hydrochloride  (ISO)
fipronil  (ISO)
flavone  (ISO)
flavonoids  (ISO)
fludioxonil  (ISO)
flumethrin  (ISO)
fluoranthene  (ISO)
fluoxastrobin  (ISO)
flutamide  (EXP,ISO)
formononetin  (ISO)
fulvestrant  (EXP,ISO)
galaxolide  (ISO)
gamma-hexachlorocyclohexane  (ISO)
gamma-tocopherol  (EXP)
gefitinib  (ISO)
genistein  (EXP,ISO)
genistein 7-O-beta-D-glucoside  (EXP)
geranial  (ISO)
geraniol  (ISO)
glucose  (ISO)
glycitein  (EXP,ISO)
glycitin  (EXP)
glyphosate  (EXP,ISO)
heptachlor  (ISO)
Heptachlor epoxide  (ISO)
herbicide  (ISO)
hexachlorobenzene  (ISO)
hexestrol  (EXP,ISO)
hydrogencarbonate  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
ibuprofen  (ISO)
Icaritin  (ISO)
ICI-164384  (EXP)
imidacloprid  (ISO)
indinavir  (ISO)
indoles  (ISO)
ipriflavone  (ISO)
iprodione  (ISO)
irilone  (ISO)
Isobutylparaben  (EXP,ISO)
isoflavones  (EXP,ISO)
Isopropylparaben  (ISO)
isorhamnetin  (ISO)
isotretinoin  (EXP)
kaempferol  (EXP,ISO)
kresoxim-methyl  (ISO)
L-ascorbic acid  (EXP)
lamivudine  (ISO)
lasofoxifene  (EXP)
leptophos  (ISO)
linuron  (ISO)
lipopolysaccharide  (ISO)
liquiritigenin  (ISO)
luteolin  (ISO)
luteolin 7-O-beta-D-glucoside  (ISO)
lycopene  (ISO)
M1  (ISO)
mancozeb  (ISO)
melatonin  (EXP)
mercury atom  (ISO)
mercury(0)  (ISO)
mestranol  (ISO)
metconazole  (ISO)
metformin  (EXP)
methimazole  (ISO)
methiocarb  (ISO)
methoxyacetic acid  (EXP,ISO)
methoxychlor  (EXP,ISO)
methyl laurate  (ISO)
Methyl palmitate  (ISO)
methylparaben  (ISO)
methylseleninic acid  (ISO)
methyltestosterone  (ISO)
metolachlor  (ISO)
mifepristone  (EXP,ISO)
Mitotane  (ISO)
MK 571  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
monoethyl phthalate  (ISO)
Moxestrol  (EXP)
mycophenolic acid  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-butylbenzenesulfonamide  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (EXP)
n-propyl gallate  (ISO)
Nafoxidine  (EXP)
nandrolone  (EXP)
Nandrolone decanoate  (EXP)
napropamide  (ISO)
naringin  (EXP)
nebivolol  (ISO)
Nonylphenol  (EXP,ISO)
norethisterone  (ISO)
Norethynodrel  (EXP)
notoginsenoside R1  (EXP)
nuarimol  (ISO)
O-Desmethylangolensin  (ISO)
octocrylene  (ISO)
ormeloxifene  (EXP)
oryzalin  (ISO)
Osajin  (ISO)
Oxadiazon  (ISO)
oxybenzone  (EXP,ISO)
ozone  (ISO)
p-tert-Amylphenol  (ISO)
p-tolualdehyde  (ISO)
paclitaxel  (ISO)
parathion-methyl  (ISO)
pendimethalin  (EXP,ISO)
perfluorododecanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenanthrene  (ISO)
phenothrin  (ISO)
phloretin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phthalic acid  (ISO)
phytoestrogen  (ISO)
picoxystrobin  (ISO)
Pomiferin  (ISO)
potassium dichromate  (EXP)
prallethrin  (ISO)
prochloraz  (ISO)
procymidone  (ISO)
progesterone  (EXP,ISO)
propamocarb  (ISO)
propargite  (ISO)
propiconazole  (ISO)
propylparaben  (EXP,ISO)
propyzamide  (ISO)
prothiofos  (ISO)
pterostilbene  (ISO)
puerarin  (EXP,ISO)
pyrazoles  (ISO)
pyrene  (ISO)
pyridaben  (ISO)
quercetin  (ISO)
quinalphos  (ISO)
raloxifene  (EXP,ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
Rhapontigenin  (ISO)
rifapentine  (ISO)
Rosavin  (ISO)
rotenone  (ISO)
royal jelly  (ISO)
rubitecan  (ISO)
rutin  (EXP)
salicylates  (ISO)
saquinavir  (ISO)
SB 203580  (ISO)
serpentine asbestos  (ISO)
silibinin  (EXP,ISO)
sodium arsenite  (ISO)
sodium hypochlorite  (ISO)
sophoraflavanone B  (EXP,ISO)
staurosporine  (ISO)
streptozocin  (ISO)
tamoxifen  (EXP,ISO)
teniposide  (ISO)
testosterone  (EXP,ISO)
Testosterone propionate  (ISO)
Tetrachlorobisphenol A  (ISO)
tetrachloromethane  (EXP)
tetrachlorvinphos  (ISO)
tetradifon  (ISO)
tetralin  (ISO)
tetramethrin  (EXP)
tibolone  (ISO)
tolclofos-methyl  (ISO)
topotecan  (ISO)
toremifene  (ISO)
toxaphene  (EXP,ISO)
trans-piceid  (ISO)
Tri-2-ethylhexyl trimellitate  (ISO)
tributylstannane  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (EXP,ISO)
trifloxystrobin  (ISO)
trifluralin  (ISO)
trifluridine  (ISO)
trilostane  (ISO)
triphenyl phosphate  (ISO)
Triphenylethylene  (ISO)
triptonide  (ISO)
triticonazole  (ISO)
undecan-2-one  (ISO)
Urolithin A  (ISO)
valinomycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP,ISO)
vincristine  (ISO)
vinyl carbamate  (ISO)
vitamin D  (ISO)
zearalenone  (EXP,ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
amygdala development  (IEP)
androgen receptor signaling pathway  (ISO)
behavioral fear response  (IDA)
brain development  (ISO)
cell population proliferation  (ISO)
cellular response to estradiol stimulus  (IEA,IEP,ISO)
cellular response to estrogen stimulus  (IBA,IEA)
cellular response to lipopolysaccharide  (IMP)
cellular response to magnetism  (IEP)
cellular response to organic cyclic compound  (IEP)
cellular response to xenobiotic stimulus  (IEP)
cerebellum development  (IEP)
epithelial cell maturation involved in prostate gland development  (ISO)
epithelial cell proliferation  (ISO)
estrous cycle  (IMP)
female gonad development  (IEP)
hormone-mediated apoptotic signaling pathway  (ISO)
hypothalamus development  (IEP)
intracellular estrogen receptor signaling pathway  (IBA,IEA,ISO,TAS)
intracellular steroid hormone receptor signaling pathway  (IDA)
learning or memory  (IMP)
male gonad development  (IEP)
negative regulation of androgen receptor signaling pathway  (ISO)
negative regulation of behavior  (IDA)
negative regulation of cell population proliferation  (ISO)
negative regulation of epithelial cell proliferation  (IDA,ISO)
negative regulation of feeding behavior  (IMP)
negative regulation of neuron apoptotic process  (IDA)
negative regulation of reactive oxygen species metabolic process  (IMP)
negative regulation of smooth muscle cell proliferation  (IMP)
negative regulation of transcription by RNA polymerase II  (IDA,IEA,ISO)
neuron migration  (ISO)
ovarian follicle development  (IEP,ISO)
positive regulation of apoptotic process  (IDA)
positive regulation of DNA-templated transcription  (IDA,IEA,ISO)
positive regulation of epidermal growth factor receptor signaling pathway  (IMP)
positive regulation of ERK1 and ERK2 cascade  (IDA,IMP)
positive regulation of transcription by RNA polymerase II  (IDA,ISO)
prostate gland development  (IEP)
prostate gland epithelium morphogenesis  (ISO)
regulation of cell population proliferation  (ISO)
regulation of DNA-templated transcription  (IEA)
regulation of transcription by RNA polymerase II  (IBA)
response to activity  (IEP)
response to bisphenol A  (IEP)
response to dexamethasone  (IEP)
response to estradiol  (IEP)
response to estrogen  (IEP)
response to ethanol  (IEP)
response to genistein  (IEP)
response to hormone  (IEP)
response to human chorionic gonadotropin  (IEP)
response to insecticide  (IEP)
response to nutrient levels  (IEP)
response to organic cyclic compound  (IEP)
response to salt  (IEP)
response to testosterone  (IEP,IMP)
response to xenobiotic stimulus  (IEP)
Sertoli cell development  (IEP)
Sertoli cell proliferation  (IMP)
uterus development  (ISO)
vagina development  (ISO)
vasodilation  (IMP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
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93. Estrogen receptor beta gene polymorphism and intraocular pressure elevation in female patients with primary open-angle glaucoma. Mabuchi F, etal., Am J Ophthalmol. 2010 May;149(5):826-30.e1-2. doi: 10.1016/j.ajo.2009.12.030.
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96. Estrogen receptor beta (ESR2) polymorphisms in familial and sporadic breast cancer. Maguire P, etal., Breast Cancer Res Treat. 2005 Nov;94(2):145-52.
97. Simultaneous disruption of estrogen receptor and Wnt/beta-catenin signaling is involved in methyl amooranin-mediated chemoprevention of mammary gland carcinogenesis in rats. Mandal A, etal., Mol Cell Biochem. 2013 Sep 29.
98. Genetic polymorphisms of estrogen receptors in patients with premature coronary artery disease. Mansur Ade P, etal., Arch Med Res. 2005 Sep-Oct;36(5):511-7.
99. Association study using single nucleotide polymorphisms in the estrogen receptor beta (ESR2) gene for preeclampsia. Maruyama A, etal., Hypertens Res. 2004 Dec;27(12):903-9.
100. A novel isoform of rat estrogen receptor beta with 18 amino acid insertion in the ligand binding domain as a putative dominant negative regular of estrogen action. Maruyama K, etal., Biochem Biophys Res Commun 1998 May 8;246(1):142-7.
101. Functional interaction of DYX1C1 with estrogen receptors suggests involvement of hormonal pathways in dyslexia. Massinen S, etal., Hum Mol Genet. 2009 Aug 1;18(15):2802-12. doi: 10.1093/hmg/ddp215. Epub 2009 May 7.
102. Novel ligands balance estrogen receptor beta and alpha agonism for safe and effective suppression of the vasomotor response in the ovariectomized female rat model of menopause. McGregor C, etal., Endocrinology. 2014 Jul;155(7):2480-91. doi: 10.1210/en.2013-1976. Epub 2014 May 13.
103. Essential role for estrogen receptor beta in stromal-epithelial regulation of prostatic hyperplasia. McPherson SJ, etal., Endocrinology. 2007 Feb;148(2):566-74. Epub 2006 Oct 26.
104. Estrogen receptor alpha and beta immunoreactive neurons in normal adult and aged female rat hippocampus: a qualitative and quantitative study. Mehra RD, etal., Brain Res. 2005 Sep 14;1056(1):22-35.
105. Estrogen receptor beta protects against acoustic trauma in mice. Meltser I, etal., J Clin Invest. 2008 Apr;118(4):1563-70. doi: 10.1172/JCI32796.
106. Estrogen-related genes and postmenopausal osteoporosis risk. Mendoza N, etal., Climacteric. 2012 Dec;15(6):587-93. doi: 10.3109/13697137.2012.656160. Epub 2012 Feb 15.
107. Estrogen stimulates galanin expression within luteinizing hormone-releasing hormone-immunoreactive (LHRH-i) neurons via estrogen receptor-beta (ERbeta) in the female rat brain. Merchenthaler I Neuropeptides. 2005 Jun;39(3):341-3.
108. Estrogen and estrogen receptor-{beta} (ER{beta})-selective ligands induce galanin expression within gonadotropin hormone-releasing hormone-immunoreactive neurons in the female rat brain. Merchenthaler I, etal., Endocrinology. 2005 Jun;146(6):2760-5. Epub 2005 Mar 24.
109. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
110. Estrogen receptor (ER)beta isoforms rather than ERalpha regulate corticotropin-releasing hormone promoter activity through an alternate pathway. Miller WJ, etal., J Neurosci. 2004 Nov 24;24(47):10628-35.
111. Multilocus analysis of estrogen-related genes in Spanish postmenopausal women suggests an interactive role of ESR1, ESR2 and NRIP1 genes in the pathogenesis of osteoporosis. Moron FJ, etal., Bone. 2006 Jul;39(1):213-21. Epub 2006 Mar 10.
112. Differential estrogen receptor expression in autoimmune myasthenia gravis. Nancy P and Berrih-Aknin S, Endocrinology. 2005 May;146(5):2345-53. Epub 2005 Jan 20.
113. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
114. Polymorphisms in genes of the steroid receptor superfamily modify postmenopausal breast cancer risk associated with menopausal hormone therapy. NO_AUTHOR Int J Cancer. 2010 Jun 15;126(12):2935-46. doi: 10.1002/ijc.24892.
115. Immunohistochemical expression of estrogen receptors alpha and beta in lobular neoplasia. Nonni A, etal., Virchows Arch. 2007 Nov;451(5):893-7. Epub 2007 Oct 9.
116. Upregulation of myocardial estrogen receptors in human aortic stenosis. Nordmeyer J, etal., Circulation. 2004 Nov 16;110(20):3270-5. Epub 2004 Nov 8.
117. Association of estrogen receptor beta (ESR2) gene polymorphism with blood pressure. Ogawa S, etal., J Hum Genet. 2000;45(6):327-30.
118. Mating changes the subcellular distribution and the functionality of estrogen receptors in the rat oviduct. Orihuela PA, etal., Reprod Biol Endocrinol. 2009 Nov 30;7:139.
119. Sex and region-specific regulation of oestrogen receptor beta in the rat hypothalamus. Orikasa C and Sakuma Y, J Neuroendocrinol. 2004 Dec;16(12):964-9.
120. Sexually dimorphic expression of estrogen receptor beta in the anteroventral periventricular nucleus of the rat preoptic area: implication in luteinizing hormone surge. Orikasa C, etal., Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):3306-11. Epub 2002 Feb 19.
121. Potential role of estrogen in regulation of the insulin-like growth factor2-H19 locus in the rat testis. Pathak S, etal., Mol Cell Endocrinol. 2010 Jan 15;314(1):110-7. doi: 10.1016/j.mce.2009.08.005. Epub 2009 Aug 14.
122. Anxiogenic effects of developmental bisphenol A exposure are associated with gene expression changes in the juvenile rat amygdala and mitigated by soy. Patisaul HB, etal., PLoS One. 2012;7(9):e43890. doi: 10.1371/journal.pone.0043890. Epub 2012 Sep 5.
123. Association of estrogen receptor beta gene polymorphisms with left ventricular mass and wall thickness in women. Peter I, etal., Am J Hypertens. 2005 Nov;18(11):1388-95.
124. Estrogen receptor beta gene variants are associated with increased risk of Alzheimer's disease in women. Pirskanen M, etal., Eur J Hum Genet. 2005 Sep;13(9):1000-6.
125. Estrogen-related abnormalities in glomerulosclerosis-prone mice: reduced mesangial cell estrogen receptor expression and prosclerotic response to estrogens. Potier M, etal., Am J Pathol. 2002 May;160(5):1877-85.
126. Estrogen receptor-beta messenger ribonucleic acid ontogeny in the prostate of normal and neonatally estrogenized rats. Prins GS, etal., Endocrinology. 1998 Mar;139(3):874-83.
127. Steroid hormone receptor expression and proliferation in rat mammary gland carcinomas induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Qiu C, etal., Carcinogenesis. 2005 Apr;26(4):763-9. Epub 2005 Jan 6.
128. Feeding soy protein isolate and treatment with estradiol have different effects on mammary gland morphology and gene expression in weanling male and female rats. Racine Miousse I, etal., Physiol Genomics. 2013 Sep 17.
129. Soy isoflavones modulate azoxymethane-induced rat colon carcinogenesis exposed pre- and postnatally and inhibit growth of DLD-1 human colon adenocarcinoma cells by increasing the expression of estrogen receptor-beta. Raju J, etal., J Nutr. 2009 Mar;139(3):474-81. doi: 10.3945/jn.108.099200. Epub 2009 Jan 13.
130. Periodic 17beta-estradiol pretreatment protects rat brain from cerebral ischemic damage via estrogen receptor-beta. Raval AP, etal., PLoS One. 2013 Apr 12;8(4):e60716. doi: 10.1371/journal.pone.0060716. Print 2013.
131. Selected variants of the steroid-5-alpha-reductase isoforms SRD5A1 and SRD5A2 and the sex steroid hormone receptors ESR1, ESR2 and PGR: no association with female pattern hair loss identified. Redler S, etal., Exp Dermatol. 2012 May;21(5):390-3. doi: 10.1111/j.1600-0625.2012.01469.x.
132. A transmembrane intracellular estrogen receptor mediates rapid cell signaling. Revankar CM, etal., Science. 2005 Mar 11;307(5715):1625-30. Epub 2005 Feb 10.
133. Bisphenol A and human chronic diseases: Current evidences, possible mechanisms, and future perspectives. Rezg R, etal., Environ Int. 2014 Mar;64C:83-90. doi: 10.1016/j.envint.2013.12.007. Epub 2013 Dec 29.
134. GOA pipeline RGD automated data pipeline
135. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
136. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
137. Disruption of estrogen receptor beta gene impairs spatial learning in female mice. Rissman EF, etal., Proc Natl Acad Sci U S A 2002 Mar 19;99(6):3996-4001. Epub 2002 Mar 12.
138. Estrogen receptor beta (ESR2) polymorphisms in interaction with estrogen receptor alpha (ESR1) and insulin-like growth factor I (IGF1) variants influence the risk of fracture in postmenopausal women. Rivadeneira F, etal., J Bone Miner Res. 2006 Sep;21(9):1443-56.
139. Evaluation of estrogen receptor alpha and beta and progesterone receptor expression and correlation with clinicopathologic factors and proliferative marker Ki-67 in breast cancers. Rosa FE, etal., Hum Pathol. 2008 Jan 29;.
140. Defining the Role of Estrogen Receptor β in the Regulation of Female Fertility. Rumi MAK, etal., Endocrinology. 2017 Jul 1;158(7):2330-2343. doi: 10.1210/en.2016-1916.
141. An ADIOL-ERbeta-CtBP transrepression pathway negatively regulates microglia-mediated inflammation. Saijo K, etal., Cell. 2011 May 13;145(4):584-95.
142. Exposure of neonatal rats to the endocrine disrupter Bisphenol A affects ontogenic expression pattern of testicular steroid receptors and their coregulators. Salian-Mehta S, etal., J Appl Toxicol. 2013 Apr 26. doi: 10.1002/jat.2882.
143. Differential expression of estrogen receptor-beta and estrogen receptor-alpha in the rat ovary. Sar M and Welsch F, Endocrinology. 1999 Feb;140(2):963-71.
144. Association of Rsa polymorphism of the estrogen receptor-beta gene with rheumatoid arthritis. Sato H, etal., Rheumatol Int. 2011 Apr 27.
145. Ciliated epithelial-specific and regional-specific expression and regulation of the estrogen receptor-beta2 in the fallopian tubes of immature rats: a possible mechanism for estrogen-mediated transport process in vivo. Shao R, etal., Am J Physiol Endocrinol Metab. 2007 Jul;293(1):E147-58. Epub 2007 Mar 20.
146. Estradiol receptors agonists induced effects in rat intestinal microcirculation during sepsis. Sharawy N, etal., Microvasc Res. 2013 Jan;85:118-27. doi: 10.1016/j.mvr.2012.10.002. Epub 2012 Oct 11.
147. Notoginsenoside Ft1 activates both glucocorticoid and estrogen receptors to induce endothelium-dependent, nitric oxide-mediated relaxations in rat mesenteric arteries. Shen K, etal., Biochem Pharmacol. 2014 Mar 1;88(1):66-74. doi: 10.1016/j.bcp.2014.01.007. Epub 2014 Jan 16.
148. Disruption of the estrogen receptor beta gene in mice causes myeloproliferative disease resembling chronic myeloid leukemia with lymphoid blast crisis. Shim GJ, etal., Proc Natl Acad Sci U S A 2003 May 27;100(11):6694-9. Epub 2003 May 9.
149. Downregulation of androgen, estrogen and progesterone receptor genes and protein is involved in aging-related erectile dysfunction. Shirai M, etal., Int J Impot Res. 2003 Dec;15(6):391-6.
150. Inner ear pathology and loss of hearing in estrogen receptor-beta deficient mice. Simonoska R, etal., J Endocrinol. 2009 Jun;201(3):397-406. doi: 10.1677/JOE-09-0060. Epub 2009 Mar 17.
151. Estrogen or estrogen receptor agonist inhibits lipopolysaccharide induced microglial activation and death. Smith JA, etal., Neurochem Res. 2011 Sep;36(9):1587-93. Epub 2010 Dec 3.
152. Depletion of oestrogen receptor-beta expression in magnocellular arginine vasopressin neurones by hypovolaemia and dehydration. Somponpun SJ and Sladek CD, J Neuroendocrinol. 2004 Jun;16(6):544-9.
153. Osmotic regulation of estrogen receptor-beta in rat vasopressin and oxytocin neurons. Somponpun SJ and Sladek CD, J Neurosci. 2003 May 15;23(10):4261-9.
154. The protective association of high plasma enterolactone with breast cancer is reasonably robust in women with polymorphisms in the estrogen receptor alpha and beta genes. Sonestedt E, etal., J Nutr. 2009 May;139(5):993-1001. doi: 10.3945/jn.108.101691. Epub 2009 Mar 25.
155. Expression of estrogen receptor ESR1 and its 46-kDa variant in the gubernaculum testis. Staub C, etal., Biol Reprod. 2005 Oct;73(4):703-12. Epub 2005 Jun 8.
156. The affinity and activity of the multiple hormone response element in the proximal promoter of the human oxytocin gene. Stedronsky K, etal., J Neuroendocrinol. 2002 Jun;14(6):472-85.
157. Attenuation of Atherogenesis via the Anti-inflammatory Effects of the Selective Estrogen Receptor Beta Modulator 8beta-VE2. Sun J, etal., J Cardiovasc Pharmacol. 2011 Oct;58(4):399-405.
158. Regulation of estrogen receptor-beta expression in the female rat hypothalamus: differential effects of dexamethasone and estradiol. Suzuki S and Handa RJ, Endocrinology. 2004 Aug;145(8):3658-70. Epub 2004 Apr 15.
159. Histological observation of the development of follicles and follicular atresia in immature rat ovaries. Takagi K, etal., Acta Med Okayama. 2007 Oct;61(5):283-98.
160. Differential expression of oestrogen receptor isoforms and androgen receptor in the normal vulva and vagina compared with vulval lichen sclerosus and chronic vaginitis. Taylor AH, etal., Br J Dermatol. 2008 Feb;158(2):319-28. Epub 2007 Dec 11.
161. Polymorphisms in the promoter region of ESR2 gene and breast cancer susceptibility. Treeck O, etal., J Steroid Biochem Mol Biol. 2009 Apr;114(3-5):207-11. doi: 10.1016/j.jsbmb.2009.02.012. Epub 2009 Mar 3.
162. Association of repeat polymorphisms in the estrogen receptors alpha, beta (ESR1, ESR2) and androgen receptor (AR) genes with the occurrence of breast cancer. Tsezou A, etal., Breast. 2008 Apr;17(2):159-66. Epub 2007 Sep 29.
163. Estrogen Rescues Pre-existing Severe Pulmonary Hypertension in Rats. Umar S, etal., Am J Respir Crit Care Med. 2011 Jun 23.
164. Expression of estrogen receptor subtypes in rat pituitary gland during pregnancy and lactation. Vaillant C, etal., Endocrinology 2002 Nov;143(11):4249-58.
165. Progestin activation of nongenomic pathways via cross talk of progesterone receptor with estrogen receptor beta induces proliferation of endometrial stromal cells. Vallejo G, etal., Mol Endocrinol. 2005 Dec;19(12):3023-37. Epub 2005 Jul 14.
166. Progesterone withdrawal, and not increased circulating relaxin, mediates the decrease in myometrial relaxin receptor (RXFP1) expression in late gestation in rats. Vodstrcil LA, etal., Biol Reprod. 2010 Nov;83(5):825-32. doi: 10.1095/biolreprod.110.084301. Epub 2010 Aug 4.
167. Association of estrogen and aromatase gene polymorphisms with systemic lupus erythematosus. Wang J, etal., Lupus. 2010 May;19(6):734-40. Epub 2010 Mar 19.
168. [Effects of static magnetic field with different exposure time on the maturation of rat osteoblasts in vitro and the expression of the estrogen receptor gene]. Wang JQ, etal., Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2013 Feb;35(1):58-63. doi: 10.3881/j.issn.1000-503X.2013.01.011.
169. Estrogen receptor (ER)beta knockout mice reveal a role for ERbeta in migration of cortical neurons in the developing brain. Wang L, etal., Proc Natl Acad Sci U S A 2003 Jan 21;100(2):703-8. Epub 2003 Jan 6.
170. Prepubertal physical activity up-regulates estrogen receptor beta, BRCA1 and p53 mRNA expression in the rat mammary gland. Wang M, etal., Breast Cancer Res Treat. 2009 May;115(1):213-20. doi: 10.1007/s10549-008-0062-x. Epub 2008 May 31.
171. Estrogen receptor beta mediates acute myocardial protection following ischemia. Wang M, etal., Surgery. 2008 Aug;144(2):233-8. Epub 2008 May 9.
172. Impact of estradiol, ER subtype specific agonists and genistein on energy homeostasis in a rat model of nutrition induced obesity. Weigt C, etal., Mol Cell Endocrinol. 2012 Apr 4;351(2):227-38. doi: 10.1016/j.mce.2011.12.013. Epub 2011 Dec 30.
173. A role for estrogen receptor beta in the regulation of growth of the ventral prostate. Weihua Z, etal., Proc Natl Acad Sci U S A 2001 May 22;98(11):6330-5.
174. An endocrine pathway in the prostate, ERbeta, AR, 5alpha -androstane-3beta,17beta -diol, and CYP7B1, regulates prostate growth. Weihua Z, etal., Proc Natl Acad Sci U S A 2002 Oct 15;99(21):13589-94.
175. Association between the estrogen receptor beta gene and age of onset of Parkinson's disease. Westberg L, etal., Psychoneuroendocrinology. 2004 Sep;29(8):993-8.
176. The relationship of estrogen receptor-alpha and -beta genes with osteoarthritis of the hand. Wise BL, etal., J Rheumatol. 2009 Dec;36(12):2772-9. doi: 10.3899/jrheum.081208. Epub 2009 Nov 2.
177. Characterization of bacterially expressed rat estrogen receptor beta ligand binding domain by mass spectrometry: structural comparison with estrogen receptor alpha. Witkowska HE, etal., Steroids. 1997 Aug-Sep;62(8-9):621-31.
178. The role of peroxisome proliferator-activated receptor-gamma and estrogen receptors in genistein-induced regulation of vascular tone in female rat aortas. Xiang Q, etal., Pharmacology. 2010;86(2):117-24. doi: 10.1159/000315065. Epub 2010 Aug 6.
179. Estrogen receptor-beta in the paraventricular nucleus and rostroventrolateral medulla plays an essential protective role in aldosterone/salt-induced hypertension in female rats. Xue B, etal., Hypertension. 2013 Jun;61(6):1255-62. doi: 10.1161/HYPERTENSIONAHA.111.00903. Epub 2013 Apr 22.
180. Estrogen receptor genotype and risk of cognitive impairment in elders: findings from the Health ABC study. Yaffe K, etal., Neurobiol Aging. 2009 Apr;30(4):607-14. Epub 2007 Sep 21.
181. Estradiol decreases rat depressive behavior by estrogen receptor beta but not alpha: no correlation with plasma corticosterone. Yang F, etal., Neuroreport. 2014 Jan 22;25(2):100-4. doi: 10.1097/WNR.0000000000000052.
182. Expression of oestrogen receptor-alpha and oestrogen receptor-beta in prostate cancer. Yang GS, etal., Chin Med J (Engl). 2007 Sep 20;120(18):1611-5.
183. Mitochondrial localization of estrogen receptor beta. Yang SH, etal., Proc Natl Acad Sci U S A. 2004 Mar 23;101(12):4130-5. Epub 2004 Mar 15.
184. Association analysis of oestrogen receptor beta gene (ESR2) polymorphisms with female pattern hair loss. Yip L, etal., Br J Dermatol. 2012 May;166(5):1131-4. doi: 10.1111/j.1365-2133.2011.10702.x. Epub 2012 Mar 5.
185. Diffusion weighted imaging evaluated the early therapy effect of tamoxifen in an MNU-induced mammary cancer rat model. Zhai G, etal., PLoS One. 2013 May 21;8(5):e64445. doi: 10.1371/journal.pone.0064445. Print 2013.
186. [Effects of naringin on proliferation, differentiation and maturation of rat calvarial osteoblasts in vitro]. Zhai YK, etal., Zhongguo Zhong Yao Za Zhi. 2013 Jan;38(1):105-11.
187. C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotection. Zhang QG, etal., Proc Natl Acad Sci U S A. 2011 Aug 30;108(35):E617-24. doi: 10.1073/pnas.1104391108. Epub 2011 Aug 1.
188. 4-Nitrophenol induces Leydig cells hyperplasia, which may contribute to the differential modulation of the androgen receptor and estrogen receptor-alpha and -beta expression in male rat testes. Zhang Y, etal., Toxicol Lett. 2013 Sep 23. pii: S0378-4274(13)01325-8. doi: 10.1016/j.toxlet.2013.09.011.
189. Estrogen receptor subtypes alpha and beta contribute to neuroprotection and increased Bcl-2 expression in primary hippocampal neurons. Zhao L, etal., Brain Res. 2004 Jun 4;1010(1-2):22-34.
190. Joint effect of estrogen receptor beta sequence variants and endogenous estrogen exposure on breast cancer risk in Chinese women. Zheng SL, etal., Cancer Res. 2003 Nov 15;63(22):7624-9.
191. Microsatellites in the estrogen receptor (ESR1, ESR2) and androgen receptor (AR) genes and breast cancer risk in African American and Nigerian women. Zheng Y, etal., PLoS One. 2012;7(7):e40494. doi: 10.1371/journal.pone.0040494. Epub 2012 Jul 11.
192. [The relationship of vitamin D endocrine system and estrogen receptor expression with bone mineral density in initial systemic lupus erythematosus]. Zheng YJ, etal., Zhonghua Nei Ke Za Zhi. 2010 Apr;49(4):309-12.
193. Abnormal vascular function and hypertension in mice deficient in estrogen receptor beta. Zhu Y, etal., Science 2002 Jan 18;295(5554):505-8.
Additional References at PubMed
PMID:9058381   PMID:9492041   PMID:9671811   PMID:9697695   PMID:10648597   PMID:10681512   PMID:10731636   PMID:10976058   PMID:11181953   PMID:11739747   PMID:11818503   PMID:11825673  
PMID:11882461   PMID:11932206   PMID:12021182   PMID:12039952   PMID:12115890   PMID:12161009   PMID:12372009   PMID:12393262   PMID:12444070   PMID:12697694   PMID:12798205   PMID:12801993  
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PMID:15219413   PMID:15236331   PMID:15261305   PMID:15278948   PMID:15280152   PMID:15344311   PMID:15345745   PMID:15474102   PMID:15579769   PMID:15862946   PMID:15862953   PMID:15935066  
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PMID:34463394   PMID:34638689   PMID:38111056  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2694,858,438 - 94,909,630 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl694,809,547 - 94,908,919 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx695,252,364 - 95,302,093 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0695,550,861 - 95,600,589 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0694,979,673 - 95,029,407 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0699,163,953 - 99,214,711 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl699,164,357 - 99,214,251 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06108,576,398 - 108,626,196 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4698,691,167 - 98,775,299 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1698,694,622 - 98,778,755 (-)NCBI
Celera693,284,596 - 93,334,744 (-)NCBICelera
RH 3.4 Map6686.1RGD
Cytogenetic Map6q24NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381464,226,707 - 64,338,613 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1464,084,232 - 64,338,112 (-)EnsemblGRCh38hg38GRCh38
GRCh371464,693,425 - 64,805,331 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361463,763,504 - 63,875,021 (-)NCBINCBI36Build 36hg18NCBI36
Build 341463,769,607 - 63,830,831NCBI
Celera1444,751,460 - 44,862,976 (-)NCBICelera
Cytogenetic Map14q23.2-q23.3NCBI
HuRef1444,866,333 - 44,977,880 (-)NCBIHuRef
CHM1_11464,633,573 - 64,745,077 (-)NCBICHM1_1
T2T-CHM13v2.01458,434,422 - 58,546,317 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391276,167,193 - 76,224,033 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1276,167,193 - 76,224,033 (-)EnsemblGRCm39 Ensembl
GRCm381276,120,419 - 76,177,259 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1276,120,419 - 76,177,259 (-)EnsemblGRCm38mm10GRCm38
MGSCv371277,221,406 - 77,278,246 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361277,039,259 - 77,096,099 (-)NCBIMGSCv36mm8
Celera1277,215,189 - 77,271,340 (-)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1233.52NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554665,575,088 - 5,638,946 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554665,587,003 - 5,644,765 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan11464,555,234 - 64,666,706 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01444,807,875 - 44,919,780 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11463,064,397 - 63,175,303 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1463,064,402 - 63,131,303 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1838,645,917 - 38,715,347 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl838,645,430 - 38,702,691 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha838,338,303 - 38,407,225 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0838,869,013 - 38,937,387 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl838,868,526 - 38,925,228 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1838,489,186 - 38,557,866 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0838,561,325 - 38,629,870 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0838,921,461 - 38,990,144 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440864066,173,041 - 66,235,531 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364957,956,766 - 8,004,357 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364957,956,168 - 8,018,356 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1193,829,560 - 193,906,565 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11193,823,666 - 193,907,330 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21215,715,909 - 215,788,512 (+)NCBI