Esr2 (estrogen receptor 2) - Rat Genome Database

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Gene: Esr2 (estrogen receptor 2) Rattus norvegicus
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Symbol: Esr2
Name: estrogen receptor 2
RGD ID: 2582
Description: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; estrogen binding activity; and steroid binding activity. Involved in several processes, including brain development; regulation of neuron death; and reproductive structure development. Located in several cellular components, including mitochondrion; perikaryon; and perinuclear region of cytoplasm. Part of protein-DNA complex. Used to study several diseases, including hypertension (multiple); obesity; peritonitis; prostate carcinoma in situ; and transient cerebral ischemia. Biomarker of asthma; brain ischemia; colitis; cystitis; and osteoporosis. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); bone disease (multiple); hypospadias; and neurodegenerative disease (multiple). Orthologous to human ESR2 (estrogen receptor 2); PARTICIPATES IN estrogen signaling pathway; bisphenol A response pathway; tamoxifen pharmacodynamics pathway; INTERACTS WITH (R,R,R)-alpha-tocopherol; (S)-naringenin; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ER-beta; Erb2; ERbeta; estrogen receptor 2 (beta); estrogen receptor 2 (ER beta); estrogen receptor 2 beta; estrogen receptor beta; nuclear receptor subfamily 3 group A member 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Esr2em1Soar  
Genetic Models: SD-Esr2em1Soar
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2694,858,438 - 94,909,630 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl694,809,547 - 94,908,919 (-)Ensembl
Rnor_6.0699,163,953 - 99,214,711 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl699,164,357 - 99,214,251 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06108,576,398 - 108,626,196 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4698,691,167 - 98,775,299 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1698,694,622 - 98,778,755 (-)NCBI
Celera693,284,596 - 93,334,744 (-)NCBICelera
RH 3.4 Map6686.1RGD
Cytogenetic Map6q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adenocarcinoma  (ISO)
adenoma  (ISO)
alopecia  (ISO,ISS)
Alzheimer's disease  (ISO,ISS)
Animal Mammary Neoplasms  (ISO)
anxiety disorder  (IDA)
aortic valve stenosis  (ISO)
asthma  (IEP)
atherosclerosis  (ISO)
atrial fibrillation  (ISO)
Blast Crisis  (ISO)
brain ischemia  (IEP)
breast cancer  (IDA,ISO,ISS)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
Cardiac Arrhythmias  (ISO)
Cocaine-Related Disorders  (ISO)
Cognitive Dysfunction  (ISO)
colitis  (IEP,ISO)
colon cancer  (IDA)
colorectal cancer  (ISO,ISS)
Colorectal Neoplasms  (ISO)
contact dermatitis  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
COVID-19  (ISO)
Crohn's disease  (ISO)
cystitis  (IEP)
Deafness  (ISO)
Endometrial Neoplasms  (ISO)
endometriosis  (ISO)
Experimental Arthritis  (IDA)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Melanoma  (ISO)
Female Infertility  (IMP,ISO)
glomerulosclerosis  (ISO)
Graves' disease  (ISO,ISS)
Hand Osteoarthritis  (ISO)
Hashimoto Disease  (ISO)
Hearing Loss  (ISO)
Hemorrhagic Shock  (IDA)
Hot Flashes  (IDA)
Hyperalgesia  (IDA,ISO)
hypertension  (IMP,ISO,ISS)
hypospadias  (ISO,ISS)
in situ carcinoma  (ISO)
inflammatory bowel disease  (IDA)
interstitial cystitis  (ISO)
Knee Osteoarthritis  (ISO)
Left Ventricular Hypertrophy  (ISO)
Lithiasis  (ISO)
Lung Injury  (IDA)
malignant astrocytoma  (ISO)
Mammary Neoplasms, Experimental  (IDA,IEP,ISO)
medulloblastoma  (ISO)
melanoma  (ISO)
mental depression  (IDA)
molybdenum cofactor deficiency type C  (ISO)
myasthenia gravis  (ISO)
myeloid leukemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
obesity  (IDA)
osteoarthritis  (ISO,ISS)
osteoporosis  (IEP,ISO,ISS)
Osteoporotic Fractures  (IEP,ISO)
ovarian dysgenesis 8  (ISO)
Parkinson's disease  (ISO,ISS)
peritonitis  (IDA)
Pituitary Neoplasms  (ISO)
Postmenopausal Osteoporosis  (ISO)
pre-eclampsia  (ISO,ISS)
primary open angle glaucoma  (ISO,ISS)
prostate cancer  (ISO,ISS)
prostate carcinoma in situ  (IDA,ISO)
prostatic hypertrophy  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary hypertension  (IDA)
retinal degeneration  (ISO)
rheumatoid arthritis  (ISO,ISS)
Sepsis  (IDA)
Spinal Cord Injuries  (IEP)
Splenomegaly  (ISO)
Stroke  (IDA)
systemic lupus erythematosus  (ISO,ISS)
systemic scleroderma  (ISO)
transient cerebral ischemia  (IMP)
transitional cell carcinoma  (ISO)
ulcerative colitis  (ISO)
urinary bladder cancer  (ISO)
Urination Disorders  (IDA)
Varicose Ulcer  (ISO)
Vulvar Lichen Sclerosus  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(24S)-24-hydroxycholesterol  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(3-phenoxyphenyl)methanol  (ISO)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-naringenin  (EXP,ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP,ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
1-bromopropane  (ISO)
1-Hydroxypyrene  (ISO)
1-naphthol  (ISO)
10H-phenothiazine  (ISO)
16-Ketoestrone  (ISO)
17alpha-estradiol  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17alpha-hydroxyprogesterone  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2'-Bisphenol F  (ISO)
2,2'-Dihydroxy-4-methoxybenzophenone  (ISO)
2,2,2-trichloroethanol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,4,5-Tetrachloro-4'-biphenylol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-bis(4-hydroxyphenyl)propionitrile  (EXP,ISO)
2,4,5-trichlorophenol  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2,4-dichlorophenol  (ISO)
2,4-Dihydroxybenzophenone  (ISO)
2,6-diisopropylnaphthalene  (ISO)
2,6-dimethylnaphthalene  (ISO)
2-hydroxy-17beta-estradiol  (EXP,ISO)
2-hydroxyestrone  (ISO)
2-tert-butylhydroquinone  (ISO)
2-tert-Butylphenol  (ISO)
22-Hydroxycholesterol  (ISO)
25-hydroxycholesterol  (ISO)
26-hydroxycholesterol  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,3'-diindolylmethane  (ISO)
3,3'-Dimethylbenzidine  (ISO)
3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol  (ISO)
3,5,6-trichloro-2-pyridinol  (ISO)
3,5,6-trichloropyridine-2-one  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-Methyl-4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3-buten-2-one  (ISO)
3-phenoxybenzoic acid  (ISO)
4'-epidoxorubicin  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4,4'-thiodiphenol  (ISO)
4-Androstenediol  (EXP)
4-chloro-3,5-dimethylphenol  (ISO)
4-ethylphenol  (ISO)
4-hydroxy-17beta-estradiol  (EXP,ISO)
4-Hydroxybenzophenone  (ISO)
4-nitrophenol  (EXP)
4-nitrotoluene  (ISO)
4-nonylphenol  (ISO)
4-octylphenol  (ISO)
4-Propylphenol  (ISO)
4-tert-butylphenol  (ISO)
4-tert-Octylphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5alpha-androstane-3alpha,17beta-diol  (EXP)
5alpha-androstane-3beta,17beta-diol  (EXP)
6-oxocampestanol  (ISO)
7,12-dimethyltetraphene  (ISO)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (ISO)
9-phenanthrol  (ISO)
acetochlor  (ISO)
acetophenone  (ISO)
acrylamide  (ISO)
adenosine  (ISO)
afimoxifene  (EXP,ISO)
aldehydo-D-glucose  (ISO)
aldrin  (ISO)
all-trans-phytoene  (ISO)
all-trans-phytofluene  (ISO)
all-trans-retinoic acid  (ISO)
alpha-hexachlorocyclohexane  (ISO)
alpha-naphthoflavone  (EXP)
alpha-Zearalanol  (EXP,ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
ammonium chloride  (EXP)
androgen antagonist  (EXP)
androst-4-ene-3,17-dione  (ISO)
androst-5-ene-3beta,17beta-diol  (EXP,ISO)
androstane-3,17-diol  (EXP,ISO)
anilines  (ISO)
apigenin  (ISO)
Aroclor 1254  (EXP,ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP,ISO)
azadirachtin A  (ISO)
bazedoxifene  (ISO)
benzo[a]pyrene  (ISO)
benzophenone  (ISO)
benzyl benzoate  (ISO)
Benzyl parahydroxybenzoate  (ISO)
Benzyl salicylate  (ISO)
beta-carotene  (ISO)
beta-hexachlorocyclohexane  (ISO)
beta-naphthoflavone  (EXP)
beta-tocopherol  (EXP)
beta-Zearalanol  (EXP)
bexarotene  (ISO)
bicalutamide  (ISO)
bifenthrin  (ISO)
biochanin A  (EXP,ISO)
biphenyl-2-ol  (ISO)
biphenyl-4-ol  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
brassinolide  (ISO)
Bromofos  (ISO)
Bromophos-ethyl  (ISO)
butanal  (ISO)
butylated hydroxyanisole  (ISO)
butylbenzene  (ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (EXP,ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
camptothecin  (ISO)
carbaryl  (ISO)
carbendazim  (EXP)
carbon nanotube  (ISO)
carfilzomib  (ISO)
cedrol  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chlorogenic acid  (EXP)
chloropropylate  (ISO)
chlorpyrifos  (ISO)
chlorpyrifos-methyl  (ISO)
chromium(6+)  (EXP)
chrysin  (ISO)
cisplatin  (ISO)
citral  (ISO)
clomiphene  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
coumaphos  (ISO)
coumestrol  (EXP,IPI,ISO)
Cuprizon  (EXP)
cyanazine  (ISO)
Cyanofenphos  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyhalothrin  (ISO)
cypermethrin  (ISO)
cyproterone acetate  (ISO)
D-aspartic acid  (ISO)
D-glucose  (ISO)
daidzein  (EXP,ISO)
daidzein 7-O-beta-D-glucoside  (EXP)
DDD  (ISO)
DDE  (EXP,ISO)
DDT  (EXP,ISO)
Decamethylcyclopentasiloxane  (ISO)
dehydroepiandrosterone  (EXP,ISO)
delta-hexachlorocyclohexane  (ISO)
delta-tocopherol  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
Di-n-hexyl phthalate  (ISO)
Di-n-octyl phthalate  (ISO)
diarsenic trioxide  (ISO)
diarylheptanoid  (ISO)
dibutyl phthalate  (EXP,ISO)
Dichlofenthion  (ISO)
dicofol  (ISO)
Dicyclohexyl phthalate  (ISO)
dieldrin  (ISO)
dienestrol  (EXP)
diethyl phthalate  (ISO)
diethylstilbestrol  (EXP,ISO)
digitoxin  (ISO)
diheptyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
Diisodecyl phthalate  (ISO)
dimethoate  (ISO)
diniconazole  (ISO)
dioscin  (ISO)
diosgenin  (ISO)
dioxygen  (EXP)
dipentyl phthalate  (ISO)
diphenylmethanol  (ISO)
dipropyl phthalate  (ISO)
disodium selenite  (ISO)
diuron  (ISO)
doxorubicin  (ISO)
dronedarone  (ISO)
emetine  (ISO)
emodin  (ISO)
endosulfan  (EXP,ISO)
endrin  (ISO)
enilconazole  (ISO)
enzacamene  (EXP,ISO)
EPN  (ISO)
equilin  (ISO)
equol  (ISO)
estradiol  (EXP)
estriol  (EXP,ISO)
estrone  (EXP,ISO)
estrone 3-sulfate  (EXP)
ethanol  (EXP)
ethion  (ISO)
Ethyl cinnamate  (ISO)
ethyl myristate  (ISO)
ethylparaben  (EXP,ISO)
etoposide  (ISO)
eugenol  (ISO)
fenamiphos  (ISO)
fenarimol  (ISO)
fenbuconazole  (ISO)
fenhexamid  (ISO)
fenitrothion  (ISO)
fenpyroximate  (ISO)
fenthion  (ISO)
fentin chloride  (ISO)
fenvalerate  (ISO)
finasteride  (ISO)
fingolimod hydrochloride  (ISO)
fipronil  (ISO)
flavone  (ISO)
fludioxonil  (ISO)
fluoranthene  (ISO)
fluoxastrobin  (ISO)
flutamide  (EXP,ISO)
formononetin  (ISO)
fulvestrant  (EXP,ISO)
galaxolide  (ISO)
gamma-hexachlorocyclohexane  (ISO)
gamma-tocopherol  (EXP)
gefitinib  (ISO)
genistein  (EXP,ISO)
genistein 7-O-beta-D-glucoside  (EXP)
geranial  (ISO)
geraniol  (ISO)
glucose  (ISO)
glycitein  (EXP,ISO)
glycitin  (EXP)
glyphosate  (EXP,ISO)
heptachlor  (ISO)
Heptachlor epoxide  (ISO)
herbicide  (ISO)
hexachlorobenzene  (ISO)
hexestrol  (EXP,ISO)
hydrogencarbonate  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
ICI-164384  (EXP)
indinavir  (ISO)
indoles  (ISO)
ipriflavone  (ISO)
iprodione  (ISO)
irilone  (ISO)
Isobutylparaben  (EXP,ISO)
isoflavones  (EXP,ISO)
Isopropylparaben  (ISO)
isorhamnetin  (ISO)
isotretinoin  (EXP)
kaempferol  (EXP,ISO)
kresoxim-methyl  (ISO)
L-ascorbic acid  (EXP)
lamivudine  (ISO)
lasofoxifene  (EXP)
leptophos  (ISO)
linuron  (ISO)
lipopolysaccharide  (ISO)
liquiritigenin  (ISO)
luteolin  (ISO)
lycopene  (ISO)
M1  (ISO)
mancozeb  (ISO)
melatonin  (EXP)
mercury atom  (ISO)
mercury(0)  (ISO)
mestranol  (ISO)
metconazole  (ISO)
metformin  (EXP)
methimazole  (ISO)
methiocarb  (ISO)
methoxyacetic acid  (EXP,ISO)
methoxychlor  (EXP,ISO)
methyl laurate  (ISO)
Methyl palmitate  (ISO)
methylparaben  (ISO)
methylseleninic acid  (ISO)
methyltestosterone  (ISO)
metolachlor  (ISO)
mifepristone  (EXP,ISO)
Mitotane  (ISO)
MK 571  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
monoethyl phthalate  (ISO)
Moxestrol  (EXP)
mycophenolic acid  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-butylbenzenesulfonamide  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
n-propyl gallate  (ISO)
Nafoxidine  (EXP)
nandrolone  (EXP)
Nandrolone decanoate  (EXP)
napropamide  (ISO)
naringin  (EXP)
nebivolol  (ISO)
Nonylphenol  (EXP,ISO)
norethisterone  (ISO)
Norethynodrel  (EXP)
notoginsenoside R1  (EXP)
nuarimol  (ISO)
O-Desmethylangolensin  (ISO)
octocrylene  (ISO)
ormeloxifene  (EXP)
oryzalin  (ISO)
Osajin  (ISO)
Oxadiazon  (ISO)
oxybenzone  (EXP,ISO)
p-tert-Amylphenol  (ISO)
p-tolualdehyde  (ISO)
paclitaxel  (ISO)
parathion-methyl  (ISO)
pendimethalin  (EXP,ISO)
perfluorododecanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenanthrene  (ISO)
phenothrin  (ISO)
PhIP  (EXP)
phloretin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phthalic acid  (ISO)
phytoestrogen  (ISO)
picoxystrobin  (ISO)
Pomiferin  (ISO)
potassium dichromate  (EXP)
prallethrin  (ISO)
prochloraz  (ISO)
procymidone  (ISO)
progesterone  (EXP,ISO)
propamocarb  (ISO)
propargite  (ISO)
propiconazole  (ISO)
propylparaben  (EXP,ISO)
propyzamide  (ISO)
prothiofos  (ISO)
pterostilbene  (ISO)
puerarin  (EXP,ISO)
pyrazoles  (ISO)
pyrene  (ISO)
pyridaben  (ISO)
quercetin  (ISO)
quinalphos  (ISO)
raloxifene  (EXP,ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
Rhapontigenin  (ISO)
rifapentine  (ISO)
Rosavin  (ISO)
rotenone  (ISO)
royal jelly  (ISO)
rubitecan  (ISO)
rutin  (EXP)
salicylates  (ISO)
saquinavir  (ISO)
SB 203580  (ISO)
serpentine asbestos  (ISO)
silibinin  (EXP,ISO)
sodium arsenite  (ISO)
sodium hypochlorite  (ISO)
sophoraflavanone B  (EXP,ISO)
staurosporine  (ISO)
streptozocin  (ISO)
tamoxifen  (EXP,ISO)
teniposide  (ISO)
testosterone  (EXP,ISO)
Testosterone propionate  (ISO)
Tetrachlorobisphenol A  (ISO)
tetrachloromethane  (EXP)
tetrachlorvinphos  (ISO)
tetradifon  (ISO)
tetralin  (ISO)
tetramethrin  (EXP)
tibolone  (ISO)
tolclofos-methyl  (ISO)
topotecan  (ISO)
toremifene  (ISO)
toxaphene  (EXP,ISO)
trans-piceid  (ISO)
Tri-2-ethylhexyl trimellitate  (ISO)
tributylstannane  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (EXP,ISO)
trifloxystrobin  (ISO)
trifluralin  (ISO)
trifluridine  (ISO)
trilostane  (ISO)
triphenyl phosphate  (ISO)
Triphenylethylene  (ISO)
triptonide  (ISO)
triticonazole  (ISO)
undecan-2-one  (ISO)
Urolithin A  (ISO)
valinomycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP,ISO)
vinyl carbamate  (ISO)
vitamin D  (ISO)
zearalenone  (EXP,ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
amygdala development  (IEP)
androgen receptor signaling pathway  (ISO)
behavioral fear response  (IDA)
brain development  (ISO)
cell population proliferation  (ISO)
cellular response to estradiol stimulus  (IEA,IEP,ISO)
cellular response to magnetism  (IEP)
cellular response to organic cyclic compound  (IEP)
cellular response to xenobiotic stimulus  (IEP)
cerebellum development  (IEP)
epithelial cell maturation involved in prostate gland development  (ISO)
epithelial cell proliferation  (ISO)
estrous cycle  (IMP)
female gonad development  (IEP)
hormone-mediated apoptotic signaling pathway  (ISO)
hypothalamus development  (IEP)
intracellular estrogen receptor signaling pathway  (IEA,ISO,TAS)
intracellular steroid hormone receptor signaling pathway  (IBA,IDA)
learning or memory  (IMP)
male gonad development  (IEP)
negative regulation of androgen receptor signaling pathway  (ISO)
negative regulation of behavior  (IDA)
negative regulation of cell death  (IMP)
negative regulation of cell population proliferation  (ISO)
negative regulation of epithelial cell proliferation  (IDA,ISO)
negative regulation of feeding behavior  (IMP)
negative regulation of neuron death  (IDA)
negative regulation of reactive oxygen species metabolic process  (IMP)
negative regulation of smooth muscle cell proliferation  (IMP)
negative regulation of transcription by RNA polymerase II  (IDA,IEA,ISO)
neuron migration  (ISO)
ovarian follicle development  (IEP,ISO)
positive regulation of apoptotic process  (IDA)
positive regulation of DNA-binding transcription factor activity  (IEA,ISO,ISS)
positive regulation of DNA-templated transcription  (IDA,IEA,ISO)
positive regulation of epidermal growth factor receptor signaling pathway  (IMP)
positive regulation of ERK1 and ERK2 cascade  (IDA,IMP)
positive regulation of transcription by RNA polymerase II  (IDA,ISO)
prostate gland development  (IEP)
prostate gland epithelium morphogenesis  (ISO)
regulation of cell population proliferation  (ISO)
regulation of DNA-templated transcription  (IEA)
regulation of neuron apoptotic process  (IDA)
regulation of transcription by RNA polymerase II  (IBA)
response to activity  (IEP)
response to bisphenol A  (IEP)
response to dexamethasone  (IEP)
response to estradiol  (IEP)
response to estrogen  (IEP)
response to ethanol  (IEP)
response to genistein  (IEP)
response to hormone  (IEP)
response to human chorionic gonadotropin  (IEP)
response to insecticide  (IEP)
response to nutrient levels  (IEP)
response to organic cyclic compound  (IEP)
response to salt  (IEP)
response to testosterone  (IEP,IMP)
response to water deprivation  (IEP)
response to xenobiotic stimulus  (IEP)
Sertoli cell development  (IEP)
Sertoli cell proliferation  (IMP)
steroid hormone mediated signaling pathway  (IEA)
uterus development  (ISO)
vagina development  (ISO)
vasodilation  (IMP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
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79. Response element sequence modulates estrogen receptor alpha and beta affinity and activity. Kulakosky PC, etal., J Mol Endocrinol. 2002 Aug;29(1):137-52.
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92. Novel actions of estrogen receptor-beta on anxiety-related behaviors. Lund TD, etal., Endocrinology. 2005 Feb;146(2):797-807. Epub 2004 Oct 28.
93. Estrogen receptor beta gene polymorphism and intraocular pressure elevation in female patients with primary open-angle glaucoma. Mabuchi F, etal., Am J Ophthalmol. 2010 May;149(5):826-30.e1-2. doi: 10.1016/j.ajo.2009.12.030.
94. Estrogen receptor alpha/beta ratio and estrogen receptor beta as predictors of endocrine therapy responsiveness-a randomized neoadjuvant trial comparison between anastrozole and tamoxifen for the treatment of postmenopausal breast cancer. Madeira M, etal., BMC Cancer. 2013 Sep 18;13:425. doi: 10.1186/1471-2407-13-425.
95. Impact of estrogen receptor beta activation on functional recovery after experimental stroke. Madinier A, etal., Behav Brain Res. 2014 Mar 15;261:282-8. doi: 10.1016/j.bbr.2013.12.046. Epub 2014 Jan 6.
96. Estrogen receptor beta (ESR2) polymorphisms in familial and sporadic breast cancer. Maguire P, etal., Breast Cancer Res Treat. 2005 Nov;94(2):145-52.
97. Simultaneous disruption of estrogen receptor and Wnt/beta-catenin signaling is involved in methyl amooranin-mediated chemoprevention of mammary gland carcinogenesis in rats. Mandal A, etal., Mol Cell Biochem. 2013 Sep 29.
98. Genetic polymorphisms of estrogen receptors in patients with premature coronary artery disease. Mansur Ade P, etal., Arch Med Res. 2005 Sep-Oct;36(5):511-7.
99. Association study using single nucleotide polymorphisms in the estrogen receptor beta (ESR2) gene for preeclampsia. Maruyama A, etal., Hypertens Res. 2004 Dec;27(12):903-9.
100. A novel isoform of rat estrogen receptor beta with 18 amino acid insertion in the ligand binding domain as a putative dominant negative regular of estrogen action. Maruyama K, etal., Biochem Biophys Res Commun 1998 May 8;246(1):142-7.
101. Functional interaction of DYX1C1 with estrogen receptors suggests involvement of hormonal pathways in dyslexia. Massinen S, etal., Hum Mol Genet. 2009 Aug 1;18(15):2802-12. doi: 10.1093/hmg/ddp215. Epub 2009 May 7.
102. Novel ligands balance estrogen receptor beta and alpha agonism for safe and effective suppression of the vasomotor response in the ovariectomized female rat model of menopause. McGregor C, etal., Endocrinology. 2014 Jul;155(7):2480-91. doi: 10.1210/en.2013-1976. Epub 2014 May 13.
103. Essential role for estrogen receptor beta in stromal-epithelial regulation of prostatic hyperplasia. McPherson SJ, etal., Endocrinology. 2007 Feb;148(2):566-74. Epub 2006 Oct 26.
104. Estrogen receptor alpha and beta immunoreactive neurons in normal adult and aged female rat hippocampus: a qualitative and quantitative study. Mehra RD, etal., Brain Res. 2005 Sep 14;1056(1):22-35.
105. Estrogen receptor beta protects against acoustic trauma in mice. Meltser I, etal., J Clin Invest. 2008 Apr;118(4):1563-70. doi: 10.1172/JCI32796.
106. Estrogen-related genes and postmenopausal osteoporosis risk. Mendoza N, etal., Climacteric. 2012 Dec;15(6):587-93. doi: 10.3109/13697137.2012.656160. Epub 2012 Feb 15.
107. Estrogen stimulates galanin expression within luteinizing hormone-releasing hormone-immunoreactive (LHRH-i) neurons via estrogen receptor-beta (ERbeta) in the female rat brain. Merchenthaler I Neuropeptides. 2005 Jun;39(3):341-3.
108. Estrogen and estrogen receptor-{beta} (ER{beta})-selective ligands induce galanin expression within gonadotropin hormone-releasing hormone-immunoreactive neurons in the female rat brain. Merchenthaler I, etal., Endocrinology. 2005 Jun;146(6):2760-5. Epub 2005 Mar 24.
109. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
110. Estrogen receptor (ER)beta isoforms rather than ERalpha regulate corticotropin-releasing hormone promoter activity through an alternate pathway. Miller WJ, etal., J Neurosci. 2004 Nov 24;24(47):10628-35.
111. Multilocus analysis of estrogen-related genes in Spanish postmenopausal women suggests an interactive role of ESR1, ESR2 and NRIP1 genes in the pathogenesis of osteoporosis. Moron FJ, etal., Bone. 2006 Jul;39(1):213-21. Epub 2006 Mar 10.
112. Differential estrogen receptor expression in autoimmune myasthenia gravis. Nancy P and Berrih-Aknin S, Endocrinology. 2005 May;146(5):2345-53. Epub 2005 Jan 20.
113. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
114. Polymorphisms in genes of the steroid receptor superfamily modify postmenopausal breast cancer risk associated with menopausal hormone therapy. NO_AUTHOR Int J Cancer. 2010 Jun 15;126(12):2935-46. doi: 10.1002/ijc.24892.
115. Immunohistochemical expression of estrogen receptors alpha and beta in lobular neoplasia. Nonni A, etal., Virchows Arch. 2007 Nov;451(5):893-7. Epub 2007 Oct 9.
116. Upregulation of myocardial estrogen receptors in human aortic stenosis. Nordmeyer J, etal., Circulation. 2004 Nov 16;110(20):3270-5. Epub 2004 Nov 8.
117. Association of estrogen receptor beta (ESR2) gene polymorphism with blood pressure. Ogawa S, etal., J Hum Genet. 2000;45(6):327-30.
118. Mating changes the subcellular distribution and the functionality of estrogen receptors in the rat oviduct. Orihuela PA, etal., Reprod Biol Endocrinol. 2009 Nov 30;7:139.
119. Sex and region-specific regulation of oestrogen receptor beta in the rat hypothalamus. Orikasa C and Sakuma Y, J Neuroendocrinol. 2004 Dec;16(12):964-9.
120. Sexually dimorphic expression of estrogen receptor beta in the anteroventral periventricular nucleus of the rat preoptic area: implication in luteinizing hormone surge. Orikasa C, etal., Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):3306-11. Epub 2002 Feb 19.
121. Potential role of estrogen in regulation of the insulin-like growth factor2-H19 locus in the rat testis. Pathak S, etal., Mol Cell Endocrinol. 2010 Jan 15;314(1):110-7. doi: 10.1016/j.mce.2009.08.005. Epub 2009 Aug 14.
122. Anxiogenic effects of developmental bisphenol A exposure are associated with gene expression changes in the juvenile rat amygdala and mitigated by soy. Patisaul HB, etal., PLoS One. 2012;7(9):e43890. doi: 10.1371/journal.pone.0043890. Epub 2012 Sep 5.
123. Association of estrogen receptor beta gene polymorphisms with left ventricular mass and wall thickness in women. Peter I, etal., Am J Hypertens. 2005 Nov;18(11):1388-95.
124. Estrogen receptor beta gene variants are associated with increased risk of Alzheimer's disease in women. Pirskanen M, etal., Eur J Hum Genet. 2005 Sep;13(9):1000-6.
125. Estrogen-related abnormalities in glomerulosclerosis-prone mice: reduced mesangial cell estrogen receptor expression and prosclerotic response to estrogens. Potier M, etal., Am J Pathol. 2002 May;160(5):1877-85.
126. Estrogen receptor-beta messenger ribonucleic acid ontogeny in the prostate of normal and neonatally estrogenized rats. Prins GS, etal., Endocrinology. 1998 Mar;139(3):874-83.
127. Steroid hormone receptor expression and proliferation in rat mammary gland carcinomas induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Qiu C, etal., Carcinogenesis. 2005 Apr;26(4):763-9. Epub 2005 Jan 6.
128. Feeding soy protein isolate and treatment with estradiol have different effects on mammary gland morphology and gene expression in weanling male and female rats. Racine Miousse I, etal., Physiol Genomics. 2013 Sep 17.
129. Soy isoflavones modulate azoxymethane-induced rat colon carcinogenesis exposed pre- and postnatally and inhibit growth of DLD-1 human colon adenocarcinoma cells by increasing the expression of estrogen receptor-beta. Raju J, etal., J Nutr. 2009 Mar;139(3):474-81. doi: 10.3945/jn.108.099200. Epub 2009 Jan 13.
130. Periodic 17beta-estradiol pretreatment protects rat brain from cerebral ischemic damage via estrogen receptor-beta. Raval AP, etal., PLoS One. 2013 Apr 12;8(4):e60716. doi: 10.1371/journal.pone.0060716. Print 2013.
131. Selected variants of the steroid-5-alpha-reductase isoforms SRD5A1 and SRD5A2 and the sex steroid hormone receptors ESR1, ESR2 and PGR: no association with female pattern hair loss identified. Redler S, etal., Exp Dermatol. 2012 May;21(5):390-3. doi: 10.1111/j.1600-0625.2012.01469.x.
132. A transmembrane intracellular estrogen receptor mediates rapid cell signaling. Revankar CM, etal., Science. 2005 Mar 11;307(5715):1625-30. Epub 2005 Feb 10.
133. Bisphenol A and human chronic diseases: Current evidences, possible mechanisms, and future perspectives. Rezg R, etal., Environ Int. 2014 Mar;64C:83-90. doi: 10.1016/j.envint.2013.12.007. Epub 2013 Dec 29.
134. GOA pipeline RGD automated data pipeline
135. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
136. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
137. Disruption of estrogen receptor beta gene impairs spatial learning in female mice. Rissman EF, etal., Proc Natl Acad Sci U S A 2002 Mar 19;99(6):3996-4001. Epub 2002 Mar 12.
138. Estrogen receptor beta (ESR2) polymorphisms in interaction with estrogen receptor alpha (ESR1) and insulin-like growth factor I (IGF1) variants influence the risk of fracture in postmenopausal women. Rivadeneira F, etal., J Bone Miner Res. 2006 Sep;21(9):1443-56.
139. Evaluation of estrogen receptor alpha and beta and progesterone receptor expression and correlation with clinicopathologic factors and proliferative marker Ki-67 in breast cancers. Rosa FE, etal., Hum Pathol. 2008 Jan 29;.
140. Defining the Role of Estrogen Receptor β in the Regulation of Female Fertility. Rumi MAK, etal., Endocrinology. 2017 Jul 1;158(7):2330-2343. doi: 10.1210/en.2016-1916.
141. An ADIOL-ERbeta-CtBP transrepression pathway negatively regulates microglia-mediated inflammation. Saijo K, etal., Cell. 2011 May 13;145(4):584-95.
142. Exposure of neonatal rats to the endocrine disrupter Bisphenol A affects ontogenic expression pattern of testicular steroid receptors and their coregulators. Salian-Mehta S, etal., J Appl Toxicol. 2013 Apr 26. doi: 10.1002/jat.2882.
143. Differential expression of estrogen receptor-beta and estrogen receptor-alpha in the rat ovary. Sar M and Welsch F, Endocrinology. 1999 Feb;140(2):963-71.
144. Association of Rsa polymorphism of the estrogen receptor-beta gene with rheumatoid arthritis. Sato H, etal., Rheumatol Int. 2011 Apr 27.
145. Ciliated epithelial-specific and regional-specific expression and regulation of the estrogen receptor-beta2 in the fallopian tubes of immature rats: a possible mechanism for estrogen-mediated transport process in vivo. Shao R, etal., Am J Physiol Endocrinol Metab. 2007 Jul;293(1):E147-58. Epub 2007 Mar 20.
146. Estradiol receptors agonists induced effects in rat intestinal microcirculation during sepsis. Sharawy N, etal., Microvasc Res. 2013 Jan;85:118-27. doi: 10.1016/j.mvr.2012.10.002. Epub 2012 Oct 11.
147. Notoginsenoside Ft1 activates both glucocorticoid and estrogen receptors to induce endothelium-dependent, nitric oxide-mediated relaxations in rat mesenteric arteries. Shen K, etal., Biochem Pharmacol. 2014 Mar 1;88(1):66-74. doi: 10.1016/j.bcp.2014.01.007. Epub 2014 Jan 16.
148. Disruption of the estrogen receptor beta gene in mice causes myeloproliferative disease resembling chronic myeloid leukemia with lymphoid blast crisis. Shim GJ, etal., Proc Natl Acad Sci U S A 2003 May 27;100(11):6694-9. Epub 2003 May 9.
149. Downregulation of androgen, estrogen and progesterone receptor genes and protein is involved in aging-related erectile dysfunction. Shirai M, etal., Int J Impot Res. 2003 Dec;15(6):391-6.
150. Inner ear pathology and loss of hearing in estrogen receptor-beta deficient mice. Simonoska R, etal., J Endocrinol. 2009 Jun;201(3):397-406. doi: 10.1677/JOE-09-0060. Epub 2009 Mar 17.
151. Estrogen or estrogen receptor agonist inhibits lipopolysaccharide induced microglial activation and death. Smith JA, etal., Neurochem Res. 2011 Sep;36(9):1587-93. Epub 2010 Dec 3.
152. Depletion of oestrogen receptor-beta expression in magnocellular arginine vasopressin neurones by hypovolaemia and dehydration. Somponpun SJ and Sladek CD, J Neuroendocrinol. 2004 Jun;16(6):544-9.
153. Osmotic regulation of estrogen receptor-beta in rat vasopressin and oxytocin neurons. Somponpun SJ and Sladek CD, J Neurosci. 2003 May 15;23(10):4261-9.
154. The protective association of high plasma enterolactone with breast cancer is reasonably robust in women with polymorphisms in the estrogen receptor alpha and beta genes. Sonestedt E, etal., J Nutr. 2009 May;139(5):993-1001. doi: 10.3945/jn.108.101691. Epub 2009 Mar 25.
155. Expression of estrogen receptor ESR1 and its 46-kDa variant in the gubernaculum testis. Staub C, etal., Biol Reprod. 2005 Oct;73(4):703-12. Epub 2005 Jun 8.
156. The affinity and activity of the multiple hormone response element in the proximal promoter of the human oxytocin gene. Stedronsky K, etal., J Neuroendocrinol. 2002 Jun;14(6):472-85.
157. Attenuation of Atherogenesis via the Anti-inflammatory Effects of the Selective Estrogen Receptor Beta Modulator 8beta-VE2. Sun J, etal., J Cardiovasc Pharmacol. 2011 Oct;58(4):399-405.
158. Regulation of estrogen receptor-beta expression in the female rat hypothalamus: differential effects of dexamethasone and estradiol. Suzuki S and Handa RJ, Endocrinology. 2004 Aug;145(8):3658-70. Epub 2004 Apr 15.
159. Histological observation of the development of follicles and follicular atresia in immature rat ovaries. Takagi K, etal., Acta Med Okayama. 2007 Oct;61(5):283-98.
160. Differential expression of oestrogen receptor isoforms and androgen receptor in the normal vulva and vagina compared with vulval lichen sclerosus and chronic vaginitis. Taylor AH, etal., Br J Dermatol. 2008 Feb;158(2):319-28. Epub 2007 Dec 11.
161. Polymorphisms in the promoter region of ESR2 gene and breast cancer susceptibility. Treeck O, etal., J Steroid Biochem Mol Biol. 2009 Apr;114(3-5):207-11. doi: 10.1016/j.jsbmb.2009.02.012. Epub 2009 Mar 3.
162. Association of repeat polymorphisms in the estrogen receptors alpha, beta (ESR1, ESR2) and androgen receptor (AR) genes with the occurrence of breast cancer. Tsezou A, etal., Breast. 2008 Apr;17(2):159-66. Epub 2007 Sep 29.
163. Estrogen Rescues Pre-existing Severe Pulmonary Hypertension in Rats. Umar S, etal., Am J Respir Crit Care Med. 2011 Jun 23.
164. Expression of estrogen receptor subtypes in rat pituitary gland during pregnancy and lactation. Vaillant C, etal., Endocrinology 2002 Nov;143(11):4249-58.
165. Progestin activation of nongenomic pathways via cross talk of progesterone receptor with estrogen receptor beta induces proliferation of endometrial stromal cells. Vallejo G, etal., Mol Endocrinol. 2005 Dec;19(12):3023-37. Epub 2005 Jul 14.
166. Progesterone withdrawal, and not increased circulating relaxin, mediates the decrease in myometrial relaxin receptor (RXFP1) expression in late gestation in rats. Vodstrcil LA, etal., Biol Reprod. 2010 Nov;83(5):825-32. doi: 10.1095/biolreprod.110.084301. Epub 2010 Aug 4.
167. Association of estrogen and aromatase gene polymorphisms with systemic lupus erythematosus. Wang J, etal., Lupus. 2010 May;19(6):734-40. Epub 2010 Mar 19.
168. [Effects of static magnetic field with different exposure time on the maturation of rat osteoblasts in vitro and the expression of the estrogen receptor gene]. Wang JQ, etal., Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2013 Feb;35(1):58-63. doi: 10.3881/j.issn.1000-503X.2013.01.011.
169. Estrogen receptor (ER)beta knockout mice reveal a role for ERbeta in migration of cortical neurons in the developing brain. Wang L, etal., Proc Natl Acad Sci U S A 2003 Jan 21;100(2):703-8. Epub 2003 Jan 6.
170. Prepubertal physical activity up-regulates estrogen receptor beta, BRCA1 and p53 mRNA expression in the rat mammary gland. Wang M, etal., Breast Cancer Res Treat. 2009 May;115(1):213-20. doi: 10.1007/s10549-008-0062-x. Epub 2008 May 31.
171. Estrogen receptor beta mediates acute myocardial protection following ischemia. Wang M, etal., Surgery. 2008 Aug;144(2):233-8. Epub 2008 May 9.
172. Impact of estradiol, ER subtype specific agonists and genistein on energy homeostasis in a rat model of nutrition induced obesity. Weigt C, etal., Mol Cell Endocrinol. 2012 Apr 4;351(2):227-38. doi: 10.1016/j.mce.2011.12.013. Epub 2011 Dec 30.
173. A role for estrogen receptor beta in the regulation of growth of the ventral prostate. Weihua Z, etal., Proc Natl Acad Sci U S A 2001 May 22;98(11):6330-5.
174. An endocrine pathway in the prostate, ERbeta, AR, 5alpha -androstane-3beta,17beta -diol, and CYP7B1, regulates prostate growth. Weihua Z, etal., Proc Natl Acad Sci U S A 2002 Oct 15;99(21):13589-94.
175. Association between the estrogen receptor beta gene and age of onset of Parkinson's disease. Westberg L, etal., Psychoneuroendocrinology. 2004 Sep;29(8):993-8.
176. The relationship of estrogen receptor-alpha and -beta genes with osteoarthritis of the hand. Wise BL, etal., J Rheumatol. 2009 Dec;36(12):2772-9. doi: 10.3899/jrheum.081208. Epub 2009 Nov 2.
177. Characterization of bacterially expressed rat estrogen receptor beta ligand binding domain by mass spectrometry: structural comparison with estrogen receptor alpha. Witkowska HE, etal., Steroids. 1997 Aug-Sep;62(8-9):621-31.
178. The role of peroxisome proliferator-activated receptor-gamma and estrogen receptors in genistein-induced regulation of vascular tone in female rat aortas. Xiang Q, etal., Pharmacology. 2010;86(2):117-24. doi: 10.1159/000315065. Epub 2010 Aug 6.
179. Estrogen receptor-beta in the paraventricular nucleus and rostroventrolateral medulla plays an essential protective role in aldosterone/salt-induced hypertension in female rats. Xue B, etal., Hypertension. 2013 Jun;61(6):1255-62. doi: 10.1161/HYPERTENSIONAHA.111.00903. Epub 2013 Apr 22.
180. Estrogen receptor genotype and risk of cognitive impairment in elders: findings from the Health ABC study. Yaffe K, etal., Neurobiol Aging. 2009 Apr;30(4):607-14. Epub 2007 Sep 21.
181. Estradiol decreases rat depressive behavior by estrogen receptor beta but not alpha: no correlation with plasma corticosterone. Yang F, etal., Neuroreport. 2014 Jan 22;25(2):100-4. doi: 10.1097/WNR.0000000000000052.
182. Expression of oestrogen receptor-alpha and oestrogen receptor-beta in prostate cancer. Yang GS, etal., Chin Med J (Engl). 2007 Sep 20;120(18):1611-5.
183. Mitochondrial localization of estrogen receptor beta. Yang SH, etal., Proc Natl Acad Sci U S A. 2004 Mar 23;101(12):4130-5. Epub 2004 Mar 15.
184. Association analysis of oestrogen receptor beta gene (ESR2) polymorphisms with female pattern hair loss. Yip L, etal., Br J Dermatol. 2012 May;166(5):1131-4. doi: 10.1111/j.1365-2133.2011.10702.x. Epub 2012 Mar 5.
185. Diffusion weighted imaging evaluated the early therapy effect of tamoxifen in an MNU-induced mammary cancer rat model. Zhai G, etal., PLoS One. 2013 May 21;8(5):e64445. doi: 10.1371/journal.pone.0064445. Print 2013.
186. [Effects of naringin on proliferation, differentiation and maturation of rat calvarial osteoblasts in vitro]. Zhai YK, etal., Zhongguo Zhong Yao Za Zhi. 2013 Jan;38(1):105-11.
187. 4-Nitrophenol induces Leydig cells hyperplasia, which may contribute to the differential modulation of the androgen receptor and estrogen receptor-alpha and -beta expression in male rat testes. Zhang Y, etal., Toxicol Lett. 2013 Sep 23. pii: S0378-4274(13)01325-8. doi: 10.1016/j.toxlet.2013.09.011.
188. Estrogen receptor subtypes alpha and beta contribute to neuroprotection and increased Bcl-2 expression in primary hippocampal neurons. Zhao L, etal., Brain Res. 2004 Jun 4;1010(1-2):22-34.
189. Joint effect of estrogen receptor beta sequence variants and endogenous estrogen exposure on breast cancer risk in Chinese women. Zheng SL, etal., Cancer Res. 2003 Nov 15;63(22):7624-9.
190. Microsatellites in the estrogen receptor (ESR1, ESR2) and androgen receptor (AR) genes and breast cancer risk in African American and Nigerian women. Zheng Y, etal., PLoS One. 2012;7(7):e40494. doi: 10.1371/journal.pone.0040494. Epub 2012 Jul 11.
191. [The relationship of vitamin D endocrine system and estrogen receptor expression with bone mineral density in initial systemic lupus erythematosus]. Zheng YJ, etal., Zhonghua Nei Ke Za Zhi. 2010 Apr;49(4):309-12.
192. Abnormal vascular function and hypertension in mice deficient in estrogen receptor beta. Zhu Y, etal., Science 2002 Jan 18;295(5554):505-8.
Additional References at PubMed
PMID:9058381   PMID:9492041   PMID:9671811   PMID:9697695   PMID:10648597   PMID:10681512   PMID:10731636   PMID:10976058   PMID:11181953   PMID:11739747   PMID:11818503   PMID:11825673  
PMID:11882461   PMID:11932206   PMID:12021182   PMID:12039952   PMID:12115890   PMID:12161009   PMID:12372009   PMID:12393262   PMID:12444070   PMID:12697694   PMID:12798205   PMID:12801993  
PMID:12856802   PMID:12867731   PMID:12933691   PMID:14502087   PMID:14552897   PMID:14604844   PMID:14613904   PMID:14614214   PMID:14644637   PMID:15112577   PMID:15187231   PMID:15215204  
PMID:15219413   PMID:15236331   PMID:15261305   PMID:15278948   PMID:15280152   PMID:15344311   PMID:15345745   PMID:15474102   PMID:15579769   PMID:15862946   PMID:15862953   PMID:15935066  
PMID:15994024   PMID:16443195   PMID:16648639   PMID:16758356   PMID:17026970   PMID:17045976   PMID:17237237   PMID:17480015   PMID:17490623   PMID:17493623   PMID:17537544   PMID:17698719  
PMID:17850458   PMID:17947358   PMID:18056768   PMID:18067893   PMID:18097519   PMID:18174277   PMID:18246095   PMID:18297067   PMID:18308321   PMID:18342348   PMID:18433985   PMID:18464259  
PMID:18492815   PMID:18511514   PMID:18617618   PMID:18627487   PMID:18701637   PMID:18709647   PMID:18753331   PMID:18805896   PMID:19022902   PMID:19057146   PMID:19094096   PMID:19126643  
PMID:19189968   PMID:19309532   PMID:19420389   PMID:19429457   PMID:19559077   PMID:19583861   PMID:19698287   PMID:19922658   PMID:19953342   PMID:20068009   PMID:20074560   PMID:20085801  
PMID:20096765   PMID:20136693   PMID:20138435   PMID:20160663   PMID:20347696   PMID:20381466   PMID:20424134   PMID:20460386   PMID:20554652   PMID:20584107   PMID:20702577   PMID:20810711  
PMID:20875808   PMID:20926581   PMID:20926671   PMID:20969598   PMID:21182203   PMID:21243777   PMID:21311134   PMID:21392135   PMID:21484804   PMID:21606911   PMID:21628965   PMID:21774811  
PMID:21777515   PMID:21782536   PMID:21808025   PMID:21884022   PMID:21951318   PMID:21972199   PMID:21981044   PMID:21981076   PMID:21995903   PMID:22142178   PMID:22152882   PMID:22169964  
PMID:22192617   PMID:22248091   PMID:22278942   PMID:22330348   PMID:22366496   PMID:22428062   PMID:22541803   PMID:22562172   PMID:22713467   PMID:22778216   PMID:23020785   PMID:23515287  
PMID:23515288   PMID:23749762   PMID:23911387   PMID:24033289   PMID:24188094   PMID:24347325   PMID:24352099   PMID:24390426   PMID:24718039   PMID:25211590   PMID:25217305   PMID:25486578  
PMID:25612677   PMID:25869617   PMID:26408543   PMID:26440063   PMID:26987957   PMID:27004961   PMID:27130032   PMID:27182159   PMID:27321970   PMID:27594441   PMID:27832635   PMID:28362134  
PMID:28542730   PMID:28863192   PMID:28919414   PMID:29030963   PMID:29127073   PMID:29261182   PMID:29394091   PMID:29421437   PMID:30113650   PMID:30277501   PMID:30296306   PMID:30447304  
PMID:30731078   PMID:30790128   PMID:30887585   PMID:31115535   PMID:31250245   PMID:31708494   PMID:31877966   PMID:31931041   PMID:33400952   PMID:33592287   PMID:34125331   PMID:34147032  
PMID:34416391   PMID:34463394   PMID:34638689  


Genomics

Candidate Gene Status
Esr2 is a candidate Gene for QTL Schws8
Comparative Map Data
Esr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2694,858,438 - 94,909,630 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl694,809,547 - 94,908,919 (-)Ensembl
Rnor_6.0699,163,953 - 99,214,711 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl699,164,357 - 99,214,251 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06108,576,398 - 108,626,196 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4698,691,167 - 98,775,299 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1698,694,622 - 98,778,755 (-)NCBI
Celera693,284,596 - 93,334,744 (-)NCBICelera
RH 3.4 Map6686.1RGD
Cytogenetic Map6q24NCBI
ESR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381464,226,707 - 64,338,613 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1464,084,232 - 64,338,112 (-)EnsemblGRCh38hg38GRCh38
GRCh371464,693,425 - 64,805,331 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361463,763,504 - 63,875,021 (-)NCBINCBI36hg18NCBI36
Build 341463,769,607 - 63,830,831NCBI
Celera1444,751,460 - 44,862,976 (-)NCBI
Cytogenetic Map14q23.2-q23.3NCBI
HuRef1444,866,333 - 44,977,880 (-)NCBIHuRef
CHM1_11464,633,573 - 64,745,077 (-)NCBICHM1_1
T2T-CHM13v2.01458,434,422 - 58,546,317 (-)NCBI
Esr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391276,167,193 - 76,224,033 (-)NCBIGRCm39mm39
GRCm39 Ensembl1276,167,193 - 76,224,033 (-)Ensembl
GRCm381276,120,419 - 76,177,259 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1276,120,419 - 76,177,259 (-)EnsemblGRCm38mm10GRCm38
MGSCv371277,221,406 - 77,278,246 (-)NCBIGRCm37mm9NCBIm37
MGSCv361277,039,259 - 77,096,099 (-)NCBImm8
Celera1277,215,189 - 77,271,340 (-)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1233.52NCBI
Esr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554665,575,088 - 5,638,946 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554665,587,003 - 5,644,765 (+)NCBIChiLan1.0ChiLan1.0
ESR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11463,064,397 - 63,175,303 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1463,064,402 - 63,131,303 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01444,807,875 - 44,919,780 (-)NCBIMhudiblu_PPA_v0panPan3
ESR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1838,645,917 - 38,715,347 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl838,645,430 - 38,702,691 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha838,338,303 - 38,407,225 (-)NCBI
ROS_Cfam_1.0838,869,013 - 38,937,387 (-)NCBI
ROS_Cfam_1.0 Ensembl838,868,526 - 38,925,228 (-)Ensembl
UMICH_Zoey_3.1838,489,186 - 38,557,866 (-)NCBI
UNSW_CanFamBas_1.0838,561,325 - 38,629,870 (-)NCBI
UU_Cfam_GSD_1.0838,921,461 - 38,990,144 (-)NCBI
Esr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864066,173,041 - 66,235,531 (+)NCBI
SpeTri2.0NW_0049364957,956,168 - 8,018,356 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ESR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1193,829,560 - 193,906,565 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11193,823,666 - 193,907,330 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21215,715,909 - 215,788,512 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ESR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12441,426,333 - 41,513,802 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2441,447,224 - 41,512,486 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605329,619,854 - 29,688,619 (-)NCBIVero_WHO_p1.0
Esr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473436,759,104 - 36,825,295 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462473436,742,913 - 36,862,993 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
D6Rat87  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2694,876,831 - 94,877,020 (+)MAPPERmRatBN7.2
Rnor_6.0699,182,033 - 99,182,221NCBIRnor6.0
Rnor_5.06108,593,793 - 108,593,981UniSTSRnor5.0
RGSC_v3.4698,742,972 - 98,743,161RGDRGSC3.4
RGSC_v3.4698,742,973 - 98,743,161UniSTSRGSC3.4
RGSC_v3.1698,746,429 - 98,746,617RGD
Celera693,302,793 - 93,302,965UniSTS
RH 3.4 Map6677.0RGD
RH 3.4 Map6677.0UniSTS
SHRSP x BN Map656.7498UniSTS
SHRSP x BN Map656.7498RGD
FHH x ACI Map668.02RGD
Cytogenetic Map6q24UniSTS
RH94710  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2694,859,175 - 94,859,351 (+)MAPPERmRatBN7.2
Rnor_6.0699,164,641 - 99,164,816NCBIRnor6.0
Rnor_5.06108,576,715 - 108,576,890UniSTSRnor5.0
RGSC_v3.4698,691,449 - 98,691,624UniSTSRGSC3.4
Celera693,284,878 - 93,285,053UniSTS
RH 3.4 Map6686.1UniSTS
Cytogenetic Map6q24UniSTS
Esr2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2694,898,051 - 94,899,380 (+)MAPPERmRatBN7.2
Rnor_6.0699,203,253 - 99,204,581NCBIRnor6.0
Rnor_5.06108,615,013 - 108,616,341UniSTSRnor5.0
RGSC_v3.4698,764,193 - 98,765,521UniSTSRGSC3.4
Celera693,323,998 - 93,325,324UniSTS
Cytogenetic Map6q24UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
634330Pia16Pristane induced arthritis QTL 163.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)645790088104200226Rat
6893332Cm74Cardiac mass QTL 740.40.64heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)657730540104085867Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)657730540104085867Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)658632962103632962Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)661747639106747639Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
1641904Alcrsp4Alcohol response QTL 4response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)667262953112262953Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)671201409116201409Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)672202632115200186Rat
70196BpQTLcluster7Blood pressure QTL cluster 76.82arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)672202632117202632Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1581550Pur8Proteinuria QTL 8total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)673463459109394713Rat
2293837Kiddil1Kidney dilation QTL 13.7kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)681132889104393926Rat
2293842Kiddil3Kidney dilation QTL 34.3kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)681132889104393926Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)682523650110548006Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)683190345106747639Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)684130881129130881Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
1300076Glom8Glomerulus QTL 870.000000009kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
1331722Thshl1Thyroid stimulating hormone level QTL 111.70.0001blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)689762877106752806Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)693701310128713626Rat