Egr3 (early growth response 3) - Rat Genome Database

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Gene: Egr3 (early growth response 3) Rattus norvegicus
Analyze
Symbol: Egr3
Name: early growth response 3
RGD ID: 2545
Description: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including cell migration involved in sprouting angiogenesis; endothelial cell chemotaxis; and positive regulation of endothelial cell proliferation. Predicted to act upstream of or within neuromuscular synaptic transmission; peripheral nervous system development; and regulation of T cell differentiation. Predicted to be located in nucleoplasm and synapse. Orthologous to human EGR3 (early growth response 3); INTERACTS WITH (+)-pilocarpine; 2,3,7,8-Tetrachlorodibenzofuran; 2-methoxyethanol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: early growth response protein 3; EGR-3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81551,560,482 - 51,565,778 (+)NCBIGRCr8
mRatBN7.21545,150,335 - 45,156,052 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1545,150,567 - 45,154,627 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1549,268,727 - 49,271,183 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01550,380,222 - 50,382,678 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01547,239,546 - 47,242,002 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01551,756,683 - 51,762,080 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1551,756,736 - 51,760,722 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01555,482,581 - 55,485,350 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41550,477,453 - 50,479,909 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11550,493,232 - 50,495,689 (+)NCBI
Celera1544,830,934 - 44,833,390 (+)NCBICelera
Cytogenetic Map15p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(-)-demecolcine  (ISO)
(S)-nicotine  (ISO)
15-acetyldeoxynivalenol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-methoxyethanol  (EXP)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-nitrophenol  (ISO)
acrylamide  (EXP)
afimoxifene  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
antimonite  (ISO)
AP20187  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
bathocuproine disulfonic acid  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bexarotene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
C.I. Natural Red 20  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
Calcimycin  (ISO)
calcitriol  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
clomiphene  (ISO)
clozapine  (ISO)
cocaine  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dichloromethane  (ISO)
diethylstilbestrol  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
divanadium pentaoxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ellagic acid  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
estriol  (ISO)
estrone  (ISO)
ethanol  (ISO)
ethylbenzene  (ISO)
fenvalerate  (EXP)
fluoxetine  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
gentamycin  (EXP)
hexestrol  (ISO)
hydroquinone  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP)
mestranol  (ISO)
methoxychlor  (ISO)
methylarsonic acid  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
morphine  (ISO)
nicotine  (ISO)
Nonylphenol  (ISO)
o-xylene  (ISO)
ozone  (ISO)
paracetamol  (EXP)
perfluorobutanesulfonic acid  (ISO)
perfluorobutyric acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
perfluoropentanoic acid  (ISO)
phenylmercury acetate  (ISO)
phenytoin  (EXP)
phorbol 13-acetate 12-myristate  (EXP)
pirinixic acid  (ISO)
progesterone  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
Shikonin  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
succimer  (ISO)
tamibarotene  (ISO)
testosterone  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
toluene  (ISO)
triadimefon  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
valproic acid  (EXP,ISO)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleoplasm  (IEA)
synapse  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Egr3/Pilot, a zinc finger transcription factor, is rapidly regulated by activity in brain neurons and colocalizes with Egr1/zif268. Yamagata K, etal., Learn Mem 1994 Jul-Aug;1(2):140-52.
Additional References at PubMed
PMID:11978828   PMID:12477932   PMID:14560009   PMID:15582775   PMID:16091474   PMID:16901909   PMID:18059339   PMID:21737317   PMID:23332764   PMID:25817788   PMID:26775236   PMID:31858986  
PMID:33723811   PMID:36098762  


Genomics

Comparative Map Data
Egr3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81551,560,482 - 51,565,778 (+)NCBIGRCr8
mRatBN7.21545,150,335 - 45,156,052 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1545,150,567 - 45,154,627 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1549,268,727 - 49,271,183 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01550,380,222 - 50,382,678 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01547,239,546 - 47,242,002 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01551,756,683 - 51,762,080 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1551,756,736 - 51,760,722 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01555,482,581 - 55,485,350 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41550,477,453 - 50,479,909 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11550,493,232 - 50,495,689 (+)NCBI
Celera1544,830,934 - 44,833,390 (+)NCBICelera
Cytogenetic Map15p11NCBI
EGR3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38822,687,659 - 22,693,480 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl822,687,659 - 22,693,480 (-)EnsemblGRCh38hg38GRCh38
GRCh37822,545,172 - 22,550,993 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36822,601,119 - 22,606,760 (-)NCBINCBI36Build 36hg18NCBI36
Build 34822,601,118 - 22,606,760NCBI
Celera821,507,165 - 21,512,936 (-)NCBICelera
Cytogenetic Map8p21.3NCBI
HuRef821,088,681 - 21,094,160 (-)NCBIHuRef
CHM1_1822,747,408 - 22,752,963 (-)NCBICHM1_1
T2T-CHM13v2.0822,961,911 - 22,967,732 (-)NCBIT2T-CHM13v2.0
Egr3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391470,314,766 - 70,320,062 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1470,314,652 - 70,320,063 (+)EnsemblGRCm39 Ensembl
GRCm381470,077,317 - 70,082,613 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1470,077,203 - 70,082,614 (+)EnsemblGRCm38mm10GRCm38
MGSCv371470,477,252 - 70,479,964 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361468,812,525 - 68,815,237 (+)NCBIMGSCv36mm8
Celera1467,617,884 - 67,620,596 (+)NCBICelera
Cytogenetic Map14D2NCBI
cM Map1436.2NCBI
Egr3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540346,105,447 - 46,108,149 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540346,105,447 - 46,108,149 (-)NCBIChiLan1.0ChiLan1.0
EGR3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2741,192,397 - 41,198,059 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1816,919,951 - 16,925,743 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0821,937,516 - 21,943,646 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1818,877,396 - 18,882,874 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl818,877,396 - 18,882,874 (-)Ensemblpanpan1.1panPan2
EGR3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12534,591,691 - 34,597,144 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2534,591,863 - 34,594,346 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2535,181,838 - 35,187,272 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02534,801,578 - 34,807,024 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2534,801,876 - 34,806,955 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12534,747,844 - 34,753,287 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02534,602,152 - 34,607,596 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02534,757,654 - 34,763,098 (+)NCBIUU_Cfam_GSD_1.0
EGR3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl146,944,935 - 6,948,580 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1146,943,184 - 6,948,507 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2147,423,458 - 7,429,476 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EGR3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1820,767,219 - 20,772,838 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl820,767,224 - 20,772,682 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605221,453,195 - 21,459,987 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Egr3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475818,180,123 - 18,186,196 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475818,180,787 - 18,186,148 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Egr3
13 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:79
Count of miRNA genes:67
Interacting mature miRNAs:72
Transcripts:ENSRNOT00000024067
Prediction methods:Microtar, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
2293686Bmd36Bone mineral density QTL 367.40.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)153361105871477291Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
2293691Bmd37Bone mineral density QTL 376.60.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)153361105871477291Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)154063126898288169Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)152788577486257085Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)153405413979054139Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
2306968Anxrr23Anxiety related response QTL 234.83reflex trait (VT:0001961)amplitude of the acoustic startle response (CMO:0001520)154063126846187442Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
7411725Strs7Sensitivity to stroke QTL 73.8cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)154028990149308583Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 62 61 30 25 30 6 186 97 93 42 58 31

Sequence


Ensembl Acc Id: ENSRNOT00000024067   ⟹   ENSRNOP00000024066
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1545,150,641 - 45,154,627 (+)Ensembl
Rnor_6.0 Ensembl1551,756,978 - 51,759,434 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000077072   ⟹   ENSRNOP00000068798
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1545,150,641 - 45,154,620 (+)Ensembl
Rnor_6.0 Ensembl1551,756,736 - 51,760,722 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000094649   ⟹   ENSRNOP00000095643
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1545,150,567 - 45,154,627 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000116948   ⟹   ENSRNOP00000089401
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1545,151,117 - 45,154,627 (+)Ensembl
RefSeq Acc Id: NM_017086   ⟹   NP_058782
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81551,560,482 - 51,565,712 (+)NCBI
mRatBN7.21545,150,755 - 45,155,986 (+)NCBI
Rnor_6.01551,756,978 - 51,759,434 (+)NCBI
Rnor_5.01555,482,581 - 55,485,350 (+)NCBI
RGSC_v3.41550,477,453 - 50,479,909 (+)RGD
Celera1544,830,934 - 44,833,390 (+)RGD
Sequence:
RefSeq Acc Id: XM_006252240   ⟹   XP_006252302
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81551,560,625 - 51,565,778 (+)NCBI
mRatBN7.21545,150,335 - 45,156,052 (+)NCBI
Rnor_6.01551,756,683 - 51,762,080 (+)NCBI
Rnor_5.01555,482,581 - 55,485,350 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039093001   ⟹   XP_038948929
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81551,560,621 - 51,565,778 (+)NCBI
mRatBN7.21545,150,894 - 45,156,052 (+)NCBI
RefSeq Acc Id: NP_058782   ⟸   NM_017086
- UniProtKB: P43301 (UniProtKB/Swiss-Prot),   A6HTI6 (UniProtKB/TrEMBL),   A0A8I6A9R7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006252302   ⟸   XM_006252240
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QCU2 (UniProtKB/TrEMBL),   A0A8I6A9R7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000068798   ⟸   ENSRNOT00000077072
Ensembl Acc Id: ENSRNOP00000024066   ⟸   ENSRNOT00000024067
RefSeq Acc Id: XP_038948929   ⟸   XM_039093001
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QCU2 (UniProtKB/TrEMBL),   A0A8I6A9R7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000089401   ⟸   ENSRNOT00000116948
Ensembl Acc Id: ENSRNOP00000095643   ⟸   ENSRNOT00000094649
Protein Domains
C2H2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P43301-F1-model_v2 AlphaFold P43301 1-387 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699801
Promoter ID:EPDNEW_R10325
Type:single initiation site
Name:Egr3_1
Description:early growth response 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01551,756,922 - 51,756,982EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2545 AgrOrtholog
BioCyc Gene G2FUF-13239 BioCyc
Ensembl Genes ENSRNOG00000017828 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055007005 UniProtKB/Swiss-Prot
  ENSRNOG00060011252 UniProtKB/Swiss-Prot
  ENSRNOG00065017375 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000024067.6 UniProtKB/TrEMBL
  ENSRNOT00000077072.3 UniProtKB/TrEMBL
  ENSRNOT00000094649.1 UniProtKB/Swiss-Prot
  ENSRNOT00000116948.1 UniProtKB/TrEMBL
  ENSRNOT00055011560 UniProtKB/Swiss-Prot
  ENSRNOT00060019030 UniProtKB/Swiss-Prot
  ENSRNOT00065028995 UniProtKB/Swiss-Prot
Gene3D-CATH Classic Zinc Finger UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7456458 IMAGE-MGC_LOAD
InterPro EGR_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25148 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:114342 IMAGE-MGC_LOAD
NCBI Gene 25148 ENTREZGENE
PANTHER EARLY GROWTH RESPONSE PROTEIN 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KRUEPPEL-LIKE TRANSCRIPTION FACTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DUF3446 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Egr3 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017828 RatGTEx
  ENSRNOG00055007005 RatGTEx
  ENSRNOG00060011252 RatGTEx
  ENSRNOG00065017375 RatGTEx
SMART ZnF_C2H2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A9R7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QCU2 ENTREZGENE, UniProtKB/TrEMBL
  A6HTI6 ENTREZGENE, UniProtKB/TrEMBL
  EGR3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q4V8L1_RAT UniProtKB/TrEMBL
UniProt Secondary A0A0G2JTQ1 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Egr3  Early growth response 3      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation mRNA rapidly and transiently induced in neurons of the hippocampus and cortex by electroconvulsive seizure 727280