Egfr (epidermal growth factor receptor) - Rat Genome Database

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Gene: Egfr (epidermal growth factor receptor) Rattus norvegicus
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Symbol: Egfr
Name: epidermal growth factor receptor
RGD ID: 2543
Description: Enables several functions, including calmodulin binding activity; enzyme binding activity; and epidermal growth factor binding activity. Involved in several processes, including blood vessel diameter maintenance; positive regulation of cell communication; and positive regulation of cell population proliferation. Located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and cytoplasmic vesicle. Is active in glutamatergic synapse and synaptic membrane. Used to study bronchiolo-alveolar adenocarcinoma; dilated cardiomyopathy; and high grade glioma. Biomarker of several diseases, including Parkinsonism; acute kidney failure; lung disease (multiple); median neuropathy; and peptic esophagitis. Human ortholog(s) of this gene implicated in several diseases, including colorectal cancer; lung cancer (multiple); pancreatic cancer; prostate cancer; and pulmonary tuberculosis. Orthologous to human EGFR (epidermal growth factor receptor); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; altered epidermal growth factor/neuregulin signaling pathway; cetuximab pharmacodynamics pathway; INTERACTS WITH (+)-pilocarpine; (R)-noradrenaline; (S)-nicotine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: avian erythroblastic leukemia viral (v-erbB) oncogene homolog; Egfr-related peptide; Epidermal growth factor receptor formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1); Epidermal growth factor receptor, formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1); ErbB-1; ERBB1; Errp
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81495,378,626 - 95,551,358 (+)NCBIGRCr8
mRatBN7.21491,176,979 - 91,349,722 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1491,177,067 - 91,344,382 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1495,489,293 - 95,663,168 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01496,733,623 - 96,907,493 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01493,198,702 - 93,372,564 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01499,919,485 - 100,104,136 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1499,919,485 - 100,098,796 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.014100,438,989 - 100,617,315 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41497,617,358 - 97,788,211 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1490,225,928 - 90,392,779 (+)NCBICelera
RH 3.4 Map14 RGD
Cytogenetic Map14q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model