Egfr (epidermal growth factor receptor) - Rat Genome Database

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Gene: Egfr (epidermal growth factor receptor) Rattus norvegicus
Symbol: Egfr
Name: epidermal growth factor receptor
RGD ID: 2543
Description: Enables several functions, including calmodulin binding activity; enzyme binding activity; and epidermal growth factor binding activity. Involved in several processes, including blood vessel diameter maintenance; positive regulation of cell communication; and positive regulation of cell population proliferation. Located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and cytoplasmic vesicle. Used to study bronchiolo-alveolar adenocarcinoma; dilated cardiomyopathy; and high grade glioma. Biomarker of several diseases, including Parkinsonism; acute kidney failure; lung disease (multiple); median neuropathy; and peptic esophagitis. Human ortholog(s) of this gene implicated in several diseases, including colorectal cancer; lung non-small cell carcinoma (multiple); pancreatic cancer; prostate cancer; and pulmonary tuberculosis. Orthologous to human EGFR (epidermal growth factor receptor); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; altered epidermal growth factor/neuregulin signaling pathway; cetuximab pharmacodynamics pathway; INTERACTS WITH (+)-pilocarpine; (R)-noradrenaline; (S)-nicotine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: avian erythroblastic leukemia viral (v-erbB) oncogene homolog; Egfr-related peptide; Epidermal growth factor receptor formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1); Epidermal growth factor receptor, formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1); ErbB-1; ERBB1; Errp
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Annotation category: suggests misassembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21491,176,979 - 91,349,722 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1491,177,067 - 91,344,382 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1495,489,293 - 95,663,168 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01496,733,623 - 96,907,493 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01493,198,702 - 93,372,564 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01499,919,485 - 100,104,136 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1499,919,485 - 100,098,796 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.014100,438,989 - 100,617,315 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41497,617,358 - 97,788,211 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1490,225,928 - 90,392,779 (+)NCBICelera
RH 3.4 Map14 RGD
Cytogenetic Map14q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (IEP,ISO)
Acute Lung Injury  (ISO)
adenocarcinoma  (ISO)
adrenocortical carcinoma  (ISO)
Alcoholic Liver Diseases  (ISO)
Alzheimer's disease  (ISO)
Animal Mammary Neoplasms  (ISO)
aortic valve disease  (ISS)
aortic valve stenosis  (ISO)
arteriovenous malformations of the brain  (ISO)
asthma  (IEP,ISO)
autistic disorder  (ISO)
autosomal recessive polycystic kidney disease  (ISO)
Bannayan-Riley-Ruvalcaba syndrome  (ISO)
Bile Duct Neoplasms  (ISO)
Brain Neoplasms  (ISO)
breast cancer  (ISO)
breast carcinoma  (ISO)
Breast Neoplasms  (ISO)
bronchiolo-alveolar adenocarcinoma  (IMP,ISO)
carcinoma  (ISO)
Cardiomegaly  (ISO)
cerebral palsy  (ISO)
Chloracne  (ISO)
cholangiocarcinoma  (ISO)
chronic obstructive pulmonary disease  (IEP,ISO)
Colonic Neoplasms  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
Coronavirus infectious disease  (ISS)
Craniofacial Abnormalities  (ISO)
dementia  (ISO)
dermatitis  (ISO)
diabetes mellitus  (ISO)
diabetic retinopathy  (ISO)
dilated cardiomyopathy  (IMP,ISO)
Disease Progression  (ISO)
endometrial carcinoma  (ISO)
Endometrioid Carcinomas  (ISO)
endometriosis  (ISO)
esophageal carcinoma  (ISO)
Esophageal Neoplasms  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (IDA)
Experimental Mammary Neoplasms  (ISO)
familial adenomatous polyposis  (ISO)
Gallbladder Neoplasms  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
head and neck cancer  (ISO)
Head and Neck Neoplasms  (ISO)
head and neck squamous cell carcinoma  (ISO)
Helicobacter Infections  (ISO)
hepatocellular carcinoma  (ISO)
hereditary breast ovarian cancer syndrome  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
high grade glioma  (IMP,ISO)
Huntington's disease  (ISO)
Hyperplasia  (IEP)
hypertension  (IEP)
Immediate Hypersensitivity  (ISO)
Inflammation  (IMP)
Insulin Resistance  (ISO)
Laryngeal Neoplasms  (ISO)
laryngeal squamous cell carcinoma  (ISO)
Left Ventricular Hypertrophy  (IDA)
leiomyoma  (ISO)
liver cirrhosis  (ISO)
lung adenocarcinoma  (ISO)
lung cancer  (ISO)
lung carcinoma  (ISO)
lung disease  (IEP)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lung small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
malignant mesothelioma  (ISO)
median neuropathy  (IEP)
Mesothelioma  (ISO)
Nasopharyngeal Neoplasms  (ISO)
Neonatal Inflammatory Skin and Bowel Disease 2  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neoplasm Recurrence, Local  (ISO)
obesity  (ISO)
oral squamous cell carcinoma  (ISO)
osteosarcoma  (ISO)
ovarian cancer  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (ISO)
papilloma  (ISO)
papillomavirus infectious disease  (ISO)
Parkinson's disease  (ISO)
Parkinsonism  (IEP)
peptic esophagitis  (IEP)
Phyllodes Tumor  (ISO)
pleomorphic xanthoastrocytoma  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary fibrosis  (IEP,ISO)
pulmonary hypertension  (ISO)
Pulmonary Hypertension, Hypoxia-Induced  (IMP)
pulmonary tuberculosis  (ISO)
rectal benign neoplasm  (ISO)
renal cell carcinoma  (ISO)
Right Ventricular Hypertrophy  (IMP)
schizophrenia  (ISO)
severe acute respiratory syndrome  (ISO)
Spinal Cord Injuries  (IEP,IMP)
squamous cell carcinoma  (ISO)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
Tobacco Use Disorder  (IEP)
tongue squamous cell carcinoma  (ISO)
transitional cell carcinoma  (ISO)
type 1 diabetes mellitus  (IEP)
type 2 diabetes mellitus  (ISO)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)
Vascular Remodeling  (IMP)
Ventricular Fibrillation  (IMP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(+)-Tetrandrine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(20R)-protopanaxadiol  (ISO)
(20S)-ginsenoside Rg3  (ISO)
(R)-noradrenaline  (EXP)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP,ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP,ISO)
1,2,3,4,7,8-Hexachlorodibenzofuran  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,2-naphthoquinone  (ISO)
1,4-benzoquinone  (ISO)
1,4-naphthoquinone  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-octadec-9-enoylglycero-3-phosphate  (ISO)
16,16-dimethylprostaglandin E2  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 17-glucosiduronic acid  (EXP)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,5-hexanedione  (EXP)
2-acetamidofluorene  (EXP)
2-deoxy-D-glucose  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methoxy-17beta-estradiol  (ISO)
2-nitrotoluene  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-methylcholanthrene  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4'-epidoxorubicin  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitrophenol  (ISO)
4-nitrotoluene  (ISO)
4-tert-Octylphenol  (EXP,ISO)
4-vinylcyclohexene dioxide  (ISO)
5,6alpha-epoxy-5alpha-cholestan-3beta-ol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
5-fluorouracil  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
6-chrysenamine  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP,ISO)
7-ketocholesterol  (EXP)
8-Br-cAMP  (ISO)
9,10-phenanthroquinone  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (EXP,ISO)
acrylamide  (ISO)
acteoside  (ISO)
actinomycin D  (EXP)
afatinib  (ISO)
afimoxifene  (ISO)
AH23848  (ISO)
AICA ribonucleotide  (ISO)
aldosterone  (EXP)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (EXP)
alpha-naphthoflavone  (ISO)
alpha-pinene  (ISO)
alprenolol  (ISO)
aluminium oxide  (ISO)
AM-251  (ISO)
amiodarone  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amosite asbestos  (EXP,ISO)
amphibole asbestos  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimonite  (ISO)
antirheumatic drug  (ISO)
apocynin  (ISO)
arachidonic acid  (EXP)
arecoline  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic acid  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
astragaloside IV  (EXP)
atenolol  (ISO)
atorvastatin calcium  (ISO)
atrazine  (ISO)
atropine  (ISO)
avobenzone  (ISO)
bafilomycin A1  (ISO)
baicalein  (ISO)
baicalin  (ISO)
benzamide  (ISO)
benzamidine  (ISO)
benzene  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
benzoic acid  (ISO)
berberine  (ISO)
betulin  (ISO)
betulinic acid  (ISO)
bicalutamide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisdemethoxycurcumin  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bosutinib  (ISO)
butan-1-ol  (EXP)
butane-2,3-dione  (ISO)
butylated hydroxyanisole  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (EXP,ISO)
calcium atom  (EXP)
calcium silicate  (ISO)
calcium(0)  (EXP)
canertinib  (ISO)
cannabidiol  (ISO)
capsaicin  (EXP,ISO)
carbon nanotube  (ISO)
carvacrol  (ISO)
carvedilol  (ISO)
casticin  (ISO)
celastrol  (ISO)
celecoxib  (EXP)
chloroprene  (EXP)
chloroquine  (EXP,ISO)
chlorothalonil  (ISO)
chlorpyrifos  (ISO)
cholesterol  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
chrysin  (ISO)
ciglitazone  (ISO)
ciguatoxin CTX1B  (ISO)
cimetidine  (ISO)
Cinobufagin  (ISO)
ciprofibrate  (EXP)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
crizotinib  (ISO)
crocidolite asbestos  (EXP,ISO)
Cryptotanshinone  (ISO)
Cuprizon  (EXP)
curcumin  (EXP,ISO)
cyanocob(III)alamin  (ISO)
cycloheximide  (EXP,ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cypermethrin  (EXP,ISO)
cytochalasin B  (ISO)
cytochalasin D  (ISO)
dacomitinib  (ISO)
daidzein  (ISO)
deguelin  (ISO)
dehydroepiandrosterone  (ISO)
delphinidin  (ISO)
deoxycholic acid  (EXP,ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
Diallyl sulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibenziodolium  (EXP,ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
Didecyldimethylammonium  (ISO)
dieldrin  (EXP)
diethylstilbestrol  (EXP)
dimethylarsinic acid  (EXP)
dioxygen  (ISO)
disodium selenite  (ISO)
dobutamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
epoxiconazole  (EXP,ISO)
equol  (ISO)
Erionite  (EXP)
erlotinib hydrochloride  (ISO)
estrone  (ISO)
ethanol  (EXP,ISO)
etoposide  (ISO)
eugenol  (ISO)
everolimus  (ISO)
Evodiamine  (ISO)
fenamidone  (ISO)
fenofibrate  (ISO)
ferric oxide  (ISO)
fisetin  (ISO)
fluoranthene  (ISO)
fluoxetine  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formononetin  (ISO)
fulvestrant  (ISO)
furan  (EXP)
galangin  (ISO)
galaxolide  (ISO)
gallic acid  (ISO)
gedunin  (ISO)
gefitinib  (EXP,ISO)
geldanamycin  (EXP,ISO)
gemcitabine  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
glafenine  (EXP)
glutathione  (ISO)
glycine betaine  (ISO)
glyphosate  (ISO)
Goe 6976  (EXP,ISO)
gold atom  (ISO)
gold(0)  (ISO)
helioxanthin  (ISO)
heparin  (ISO)
herbicide  (EXP)
hexachlorobenzene  (EXP,ISO)
hexadecanoic acid  (ISO)
histamine  (ISO)
hyaluronic acid  (ISO)
hydrogen chloride  (EXP)
hydrogen peroxide  (EXP,ISO)
hydroxamic acid  (ISO)
hyperforin  (ISO)
hypochlorous acid  (ISO)
icariin  (EXP)
icariside II  (ISO)
ICI-164384  (ISO)
indole-3-methanol  (ISO)
indometacin  (EXP,ISO)
inulin  (ISO)
irbesartan  (EXP)
irinotecan  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
isoflavones  (EXP)
isoprenaline  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
JTE-013  (ISO)
ketoconazole  (EXP,ISO)
KN-93  (EXP,ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lansoprazole  (ISO)
lapatinib  (ISO)
lead diacetate  (EXP,ISO)
lead nitrate  (ISO)
lead(0)  (EXP)
leflunomide  (ISO)
leukotriene C4  (ISO)
linalool  (ISO)
linuron  (EXP)
lipopolysaccharide  (ISO)
lithium chloride  (ISO)
lovastatin  (ISO)
luteolin  (ISO)
LY294002  (ISO)
Maduramicin  (EXP)
magnesium dichloride  (ISO)
Malabaricone C  (ISO)
manganese(II) chloride  (EXP,ISO)
melittin  (ISO)
menadione  (EXP)
mercury dichloride  (EXP,ISO)
metamizole sodium  (EXP)
methapyrilene  (EXP)
methidathion  (ISO)
methimazole  (EXP)
methotrexate  (EXP,ISO)
methoxychlor  (EXP,ISO)
Methylazoxymethanol acetate  (EXP)
methylmercury chloride  (ISO)
mevalonic acid  (EXP)
microcystin-LR  (ISO)
mifepristone  (EXP,ISO)
MK-2206  (ISO)
monosodium L-glutamate  (EXP,ISO)
myo-inositol hexakisphosphate  (ISO)
myricetin  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetylcysteamine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-methylformamide  (ISO)
N-methylnicotinate  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
naphthalene  (ISO)
naringin  (ISO)
nefazodone  (EXP)
neocuproine  (ISO)
neratinib  (ISO)
nevirapine  (ISO)
nickel dichloride  (EXP,ISO)
nickel subsulfide  (EXP)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotine  (EXP,ISO)
nobiletin  (EXP)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
oleic acid  (ISO)
omipalisib  (ISO)
oridonin  (ISO)
osimertinib  (ISO)
ouabain  (ISO)
oxaliplatin  (EXP,ISO)
oxazepam  (ISO)
oxytocin  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
p-tert-Amylphenol  (EXP,ISO)
paclitaxel  (ISO)
Paeonol  (EXP)
pamidronate  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
parathion  (ISO)
paroxetine  (ISO)
PD 168393  (EXP,ISO)
pentane-2,3-dione  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
PHA-665752  (ISO)
phenobarbital  (EXP,ISO)
phenylarsine oxide  (ISO)
phenylephrine  (EXP,ISO)
phenylmercury acetate  (ISO)
phloretin  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phorone  (ISO)
phosphoramidon  (ISO)
Phytolaccoside E  (ISO)
piperonyl butoxide  (ISO)
pirfenidone  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (EXP,ISO)
platycodin D  (ISO)
ponatinib  (ISO)
potassium chromate  (ISO)
primaquine  (ISO)
prochloraz  (EXP)
procymidone  (EXP)
progesterone  (EXP,ISO)
propofol  (ISO)
propranolol  (ISO)
prostaglandin E2  (ISO)
protein kinase inhibitor  (ISO)
protoporphyrin  (ISO)
Ptaquiloside  (ISO)
pterostilbene  (ISO)
purpurin  (ISO)
pyocyanine  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
quinazolines  (ISO)
quinolin-8-ol  (ISO)
rac-lactic acid  (ISO)
raloxifene  (EXP,ISO)
ranitidine  (EXP)
reactive oxygen species  (EXP,ISO)
resveratrol  (ISO)
romidepsin  (ISO)
rotenone  (EXP)
rottlerin  (ISO)
ruthenium atom  (ISO)
rutin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
scopolamine  (EXP)
selenium atom  (ISO)
selenomethionine  (ISO)
senecionine  (ISO)
sepantronium  (ISO)
serpentine asbestos  (ISO)
sertraline  (ISO)
silicon dioxide  (ISO)
simvastatin  (EXP)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium fluoride  (ISO)
sodium hydroxide  (ISO)
sorafenib  (ISO)
sotorasib  (ISO)
sphingosine 1-phosphate  (ISO)
staurosporine  (ISO)
stilbenoid  (ISO)
SU6656  (ISO)
succimer  (ISO)
sulfadimethoxine  (EXP)
sulfasalazine  (ISO)
sulindac sulfide  (ISO)
sulindac sulfone  (EXP,ISO)
Sulpyrine  (EXP)
sunitinib  (ISO)
suramin  (EXP)
taiwanin C  (ISO)
tamoxifen  (ISO)
tanespimycin  (ISO)
taurocholic acid  (ISO)
tephrosin  (ISO)
Terfenadine  (ISO)
teriflunomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
Tetrachlorobisphenol A  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
tetramethylpyrazine  (ISO)
tetraphene  (ISO)
tetrathiomolybdate(2-)  (ISO)
thapsigargin  (ISO)
theaflavin  (ISO)
thioacetamide  (EXP)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP,ISO)
torin 1  (ISO)
trans-piceid  (ISO)
triamterene  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP,ISO)
Triptolide  (ISO)
troglitazone  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
trovafloxacin  (ISO)
tyrphostin AG 1478  (EXP,ISO)
U-73122  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
ursolic acid  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vanadyl sulfate  (ISO)
vandetanib  (ISO)
veliparib  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (EXP,ISO)
WIN 55212-2  (ISO)
wortmannin  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc sulfate  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
astrocyte activation  (IMP)
cell morphogenesis  (ISO)
cell population proliferation  (ISO)
cell surface receptor signaling pathway  (ISO)
cell-cell adhesion  (ISO)
cellular response to amino acid stimulus  (ISO)
cellular response to cadmium ion  (ISO)
cellular response to dexamethasone stimulus  (IEP)
cellular response to epidermal growth factor stimulus  (IDA)
cellular response to estradiol stimulus  (ISO)
cellular response to growth factor stimulus  (IEP,ISO)
cellular response to mechanical stimulus  (IEP)
cellular response to reactive oxygen species  (ISO)
cellular response to xenobiotic stimulus  (IEP)
cerebral cortex cell migration  (ISO)
circadian rhythm  (IEP)
digestive tract morphogenesis  (ISO)
diterpenoid metabolic process  (IEP)
embryonic placenta development  (ISO)
epidermal growth factor receptor signaling pathway  (IDA,IMP,ISO)
epidermis development  (ISO)
epithelial cell proliferation  (ISO)
ERBB2-EGFR signaling pathway  (ISO)
eyelid development in camera-type eye  (ISO)
hair follicle development  (IEP,ISO)
hydrogen peroxide metabolic process  (IEP)
intracellular signal transduction  (IDA)
learning or memory  (IDA)
liver development  (IEP)
liver regeneration  (IEP,IMP)
lung development  (IEP)
midgut development  (IEP)
morphogenesis of an epithelial fold  (ISO)
negative regulation of apoptotic process  (IBA,IMP,ISO)
negative regulation of cardiocyte differentiation  (ISO)
negative regulation of epidermal growth factor receptor signaling pathway  (ISO)
negative regulation of mitotic cell cycle  (IMP)
negative regulation of protein catabolic process  (ISO)
neurogenesis  (IBA)
neuron projection morphogenesis  (IMP)
ovulation cycle  (IMP)
peptidyl-tyrosine phosphorylation  (IDA)
phosphorylation  (IEA)
positive regulation of bone resorption  (IMP)
positive regulation of canonical Wnt signaling pathway  (ISO)
positive regulation of cell growth  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of DNA repair  (ISO)
positive regulation of DNA replication  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of epithelial cell proliferation  (IBA,ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of G1/S transition of mitotic cell cycle  (ISO)
positive regulation of glial cell proliferation  (IMP)
positive regulation of MAPK cascade  (IMP)
positive regulation of miRNA transcription  (ISO)
positive regulation of mucus secretion  (IMP)
positive regulation of nitric oxide mediated signal transduction  (ISO)
positive regulation of non-canonical NF-kappaB signal transduction  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of phosphorylation  (ISO)
positive regulation of prolactin secretion  (IDA)
positive regulation of protein localization to plasma membrane  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of smooth muscle cell proliferation  (IMP)
positive regulation of superoxide anion generation  (IMP)
positive regulation of synaptic transmission, glutamatergic  (IMP)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of vasoconstriction  (IMP)
protein autophosphorylation  (IDA)
receptor-mediated endocytosis  (ISO)
regulation of cell population proliferation  (ISO)
regulation of ERK1 and ERK2 cascade  (ISO)
regulation of JNK cascade  (ISO)
regulation of peptidyl-tyrosine phosphorylation  (ISO)
regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
response to calcium ion  (IMP)
response to cobalamin  (IEP)
response to estradiol  (IEP)
response to hydroxyisoflavone  (IEP)
response to lipid  (IEP)
response to organic cyclic compound  (IEP)
response to oxidative stress  (IEP)
response to UV-A  (ISO)
salivary gland morphogenesis  (ISO)
signal transduction  (ISO)
tongue development  (IEP)
translation  (IDA)
transmembrane receptor protein tyrosine kinase signaling pathway  (IBA)
vasodilation  (IMP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References - curated
# Reference Title Reference Citation
1. Surgical injury enhances the expression of genes that mediate breast cancer metastasis to the lung. Al-Sahaf O, etal., Ann Surg. 2010 Dec;252(6):1037-43.
2. Gene expression profiling of ERBB receptors and ligands in human transitional cell carcinoma of the bladder. Amsellem-Ouazana D, etal., J Urol. 2006 Mar;175(3 Pt 1):1127-32.
3. ErbB receptors modulation in different types of peripheral nerve regeneration. Audisio C, etal., Neuroreport. 2008 Oct 29;19(16):1605-9. doi: 10.1097/WNR.0b013e32831313ef.
4. Epidermal growth factor receptor distribution during chemotactic responses. Bailly M, etal., Mol Biol Cell. 2000 Nov;11(11):3873-83.
5. Co-localization of multiple ErbB receptors in stratified epithelium of oral squamous cell carcinoma. Bei R, etal., J Pathol. 2001 Oct;195(3):343-8. doi: 10.1002/path.965.
6. Decreased levels of hepatic epidermal growth factor receptors in obese hyperglycemic rodents. Blackshear PJ, etal., J Biol Chem. 1987 Sep 5;262(25):12356-64.
7. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. Bonner JA, etal., N Engl J Med. 2006 Feb 9;354(6):567-78.
8. Immunohistochemical expression patterns of the HER4 receptors in normal mucosa and in laryngeal squamous cell carcinomas: antioncogenic significance of the HER4 protein in laryngeal squamous cell carcinoma. Bussu F, etal., Laryngoscope. 2012 Aug;122(8):1724-33. doi: 10.1002/lary.23311. Epub 2012 May 1.
9. Genetic influences on asthma susceptibility in the developing lung. Carpe N, etal., Am J Respir Cell Mol Biol. 2010 Dec;43(6):720-30. Epub 2010 Jan 29.
10. Expression of neuregulins and their putative receptors, ErbB2 and ErbB3, is induced during Wallerian degeneration. Carroll SL, etal., J Neurosci 1997 Mar 1;17(5):1642-59.
11. Diverse expression of ErbB receptor proteins during rat liver development and regeneration. Carver RS, etal., Gastroenterology. 2002 Dec;123(6):2017-27.
12. Repetitive peroxide exposure reveals pleiotropic mitogen-activated protein kinase signaling mechanisms. Chadwick W, etal., J Signal Transuct. 2011;2011. pii: 636951.
13. Mice mutant for Egfr and Shp2 have defective cardiac semilunar valvulogenesis. Chen B, etal., Nat Genet 2000 Mar;24(3):296-9.
14. EGFR-activating mutations, DNA copy number abundance of ErbB family, and prognosis in lung adenocarcinoma. Chen HY, etal., Oncotarget. 2016 Feb 23;7(8):9017-25. doi: 10.18632/oncotarget.7029.
15. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. Cunningham D, etal., N Engl J Med. 2004 Jul 22;351(4):337-45.
16. Protein levels and gene expressions of the epidermal growth factor receptors, HER1, HER2, HER3 and HER4 in benign and malignant ovarian tumors. Dahl Steffensen K, etal., Int J Oncol. 2008 Jul;33(1):195-204.
17. Expression of epidermal growth factors and their receptors in the bronchial epithelium of subjects with chronic obstructive pulmonary disease. de Boer WI, etal., Am J Clin Pathol. 2006 Feb;125(2):184-92.
18. Elastase-released epidermal growth factor recruits epidermal growth factor receptor and extracellular signal-regulated kinases to down-regulate tropoelastin mRNA in lung fibroblasts. DiCamillo SJ, etal., J Biol Chem 2002 May 24;277(21):18938-46. Epub 2002 Mar 11.
19. The epidermal growth factor receptor tyrosine kinase phosphorylates connexin32. Diez JA, etal., Mol Cell Biochem. 1998 Oct;187(1-2):201-10.
20. Expression of the epidermal growth factor system in endometrioid endometrial cancer. Ejskjaer K, etal., Gynecol Oncol. 2007 Jan;104(1):158-67. Epub 2006 Sep 7.
21. Epidermal growth factor receptor in synaptic fractions of the rat central nervous system. Faundez V, etal., J Biol Chem. 1992 Oct 5;267(28):20363-70.
22. Activation of epidermal growth factor receptor mediates reperfusion arrhythmias in anaesthetized rats. Feng M, etal., Cardiovasc Res. 2012 Jan 1;93(1):60-8. doi: 10.1093/cvr/cvr281. Epub 2011 Oct 25.
23. Epidermal growth factor receptors in placentae and fetal membranes from hypertension-complicated pregnancies. Ferrandina G, etal., Hum Reprod. 1995 Jul;10(7):1845-9.
24. Creatine activates airway epithelium in asthma. Ferreira SC, etal., Int J Sports Med. 2010 Dec;31(12):906-12. Epub 2010 Nov 11.
25. Prevention of renal vascular and glomerular fibrosis by epidermal growth factor receptor inhibition. Francois H, etal., FASEB J. 2004 May;18(7):926-8. Epub 2004 Mar 19.
26. Epidermal growth factor receptor family in lung cancer and premalignancy. Franklin WA, etal., Semin Oncol. 2002 Feb;29(1 Suppl 4):3-14.
27. The prognostic significance of human epidermal growth factor receptor correlations in squamous cell cervical carcinoma. Fuchs I, etal., Anticancer Res. 2007 Mar-Apr;27(2):959-63.
28. Increased expression of epidermal growth factor receptors in basal cell hyperplasia of the oesophagus after acid reflux oesophagitis in rats. Fujiwara Y, etal., Aliment Pharmacol Ther. 2002 Apr;16 Suppl 2:52-8.
29. Abnormal expression of epidermal growth factor and its receptor in the forebrain and serum of schizophrenic patients. Futamura T, etal., Mol Psychiatry. 2002;7(7):673-82.
30. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
31. Molecular analysis of metaplastic breast carcinoma: high EGFR copy number via aneusomy. Gilbert JA, etal., Mol Cancer Ther. 2008 Apr;7(4):944-51.
32. Histone deacetylase inhibition attenuates diabetes-associated kidney growth: potential role for epigenetic modification of the epidermal growth factor receptor. Gilbert RE, etal., Kidney Int. 2011 Mar 9.
33. A simple in silico strategy identifies candidate biomarkers for the diagnosis of liver fibrosis in morbidly obese subjects. Giraudi PJ, etal., Liver Int. 2018 Jan;38(1):155-163. doi: 10.1111/liv.13505. Epub 2017 Jul 21.
34. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
35. Results from a monocentric phase II trial of erlotinib in patients with metastatic prostate cancer. Gravis G, etal., Ann Oncol. 2008 May 7;.
36. Distribution of epidermal growth factor receptors in rat tissues during embryonic skin development, hair formation, and the adult hair growth cycle. Green MR and Couchman JR, J Invest Dermatol. 1984 Aug;83(2):118-23.
37. Epidermal growth factor induction of phenotype-dependent cell cycle arrest in vascular smooth muscle cells is through the mitogen-activated protein kinase pathway. Gui Y and Zheng XL, J Biol Chem. 2003 Dec 26;278(52):53017-25. Epub 2003 Oct 9.
38. Gastrin stimulates cyclooxygenase-2 expression in intestinal epithelial cells through multiple signaling pathways. Evidence for involvement of ERK5 kinase and transactivation of the epidermal growth factor receptor. Guo YS, etal., J Biol Chem 2002 Dec 13;277(50):48755-63.
39. The role of the epidermal growth factor receptor in sustaining neutrophil inflammation in severe asthma. Hamilton LM, etal., Clin Exp Allergy. 2003 Feb;33(2):233-40.
40. The promotion of neural regeneration in an extreme rat spinal cord injury model using a collagen scaffold containing a collagen binding neuroprotective protein and an EGFR neutralizing antibody. Han Q, etal., Biomaterials. 2010 Dec;31(35):9212-20.
41. Monoclonal antibodies against epidermal growth factor receptor induce prolactin synthesis in cultured rat pituitary cells (GH3). Hapgood J, etal., Proc Natl Acad Sci U S A. 1983 Nov;80(21):6451-5.
42. EGFR Tyrosine Kinase Inhibition Worsens Acute Lung Injury in Mice with Repairing Airway Epithelium. Harada C, etal., Am J Respir Crit Care Med. 2011 Mar 15;183(6):743-51. Epub 2010 Oct 8.
43. Reversal of lung lesions in transgenic transforming growth factor alpha mice by expression of mutant epidermal growth factor receptor. Hardie WD, etal., Am J Respir Cell Mol Biol. 1996 Oct;15(4):499-508.
44. Second-line erlotinib in patients with advanced non-small-cell lung cancer: Subgroup analyses from the TRUST study. Heigener DF, etal., Lung Cancer. 2011 Mar 23.
45. Control of the epidermal growth factor receptor and its ligands during renal injury. Hise MK, etal., Nephron. 2001 May;88(1):71-9.
46. Kras, Egfr, and Tp53 Mutations in B6C3F1/N Mouse and F344/NTac Rat Alveolar/Bronchiolar Carcinomas Resulting from Chronic Inhalation Exposure to Cobalt Metal. Hong HH, etal., Toxicol Pathol. 2015 Aug;43(6):872-82. doi: 10.1177/0192623315581192. Epub 2015 Jun 9.
47. A novel role for protein tyrosine phosphatase shp1 in controlling glial activation in the normal and injured nervous system. Horvat A, etal., J Neurosci 2001 Feb 1;21(3):865-74.
48. Altered gene activity of epidermal growth factor receptor (ErbB-1) in the hypothalamus of aging female rat is linked to abnormal estrous cycles. Hou J, etal., Endocrinology 2002 Feb;143(2):577-86.
49. Galphaq expression activates EGFR and induces Akt mediated cardiomyocyte survival: dissociation from Galphaq mediated hypertrophy. Howes AL, etal., J Mol Cell Cardiol. 2006 May;40(5):597-604. Epub 2006 Feb 8.
50. Endothelin-1 activates mesangial cell ERK1/2 via EGF-receptor transactivation and caveolin-1 interaction. Hua H, etal., Am J Physiol Renal Physiol 2003 Feb;284(2):F303-12.
51. Impact of Pulmonary Tuberculosis on the EGFR Mutational Status and Clinical Outcome in Patients with Lung Adenocarcinoma. Hwang IK, etal., Cancer Res Treat. 2019 Jan;51(1):158-168. doi: 10.4143/crt.2018.084. Epub 2018 Apr 2.
52. EGF receptor antiserum inhibits bone resorbing activity produced by a rat Leydig cell tumor associated with the humoral hypercalcemia of malignancy. Ibbotson KJ, etal., Endocrinology. 1985 Jan;116(1):469-71.
53. Evaluation of malignancy and the prognosis of esophageal cancer based on an immunohistochemical study (p53, E-cadherin, epidermal growth factor receptor). Inada S, etal., Surg Today. 1999;29(6):493-503.
54. Expression and clinical significance of erb-B receptor family in hepatocellular carcinoma. Ito Y, etal., Br J Cancer. 2001 May 18;84(10):1377-83. doi: 10.1054/bjoc.2000.1580.
55. Influences of dopaminergic lesion on epidermal growth factor-ErbB signals in Parkinson's disease and its model: neurotrophic implication in nigrostriatal neurons. Iwakura Y, etal., J Neurochem. 2005 May;93(4):974-83.
56. 3',4'-Dimethoxythioflavone induces endothelium-dependent vasorelaxation through activation of epidermal growth factor receptor. Jang EJ, etal., Naunyn Schmiedebergs Arch Pharmacol. 2012 Dec 12.
57. Pretranslational and posttranslational regulation of the EGF receptor during the prereplicative phase of liver regeneration. Johansson S, etal., Hepatology. 1990 Sep;12(3 Pt 1):533-41.
58. The impact of Helicobacter pylori on EGF, EGF receptor, and the c-erb-B2 expression. Jurkowska G, etal., Adv Med Sci. 2014 Sep;59(2):221-6. doi: 10.1016/j.advms.2014.01.006. Epub 2014 Jun 9.
59. Antisense to epidermal growth factor receptor prevents the development of left ventricular hypertrophy. Kagiyama S, etal., Hypertension. 2003 Mar;41(3 Pt 2):824-9. Epub 2002 Dec 2.
60. Expression of the HER family mRNA in breast cancer tissue and association with cell cycle inhibitors p21(waf1) and p27(kip1). Kalemi TG, etal., Anticancer Res. 2007 Mar-Apr;27(2):913-20.
61. ER2, a novel human anti-EGFR monoclonal antibody inhibit tumor activity in non-small cell lung cancer models. Kang HN, etal., Lung Cancer. 2016 May;95:57-64. doi: 10.1016/j.lungcan.2016.02.013. Epub 2016 Feb 27.
62. alpha(2)-Adre