Ednrb (endothelin receptor type B) - Rat Genome Database

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Gene: Ednrb (endothelin receptor type B) Rattus norvegicus
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Symbol: Ednrb
Name: endothelin receptor type B
RGD ID: 2536
Description: Enables endothelin receptor activity and type 1 angiotensin receptor binding activity. Involved in several processes, including blood vessel diameter maintenance; cGMP-mediated signaling; and positive regulation of penile erection. Located in nuclear membrane. Used to study several diseases, including artery disease (multiple); lymphopenia; megacolon (multiple); portal hypertension; and type 2 diabetes mellitus. Biomarker of asthma; hepatopulmonary syndrome; and hypertension. Human ortholog(s) of this gene implicated in ABCD syndrome; Hirschsprung's disease; Waardenburg syndrome; Waardenburg syndrome type 4A; and asthma. Orthologous to human EDNRB (endothelin receptor type B); PARTICIPATES IN calcium/calmodulin dependent kinase signaling pathway; endothelin signaling pathway; inflammatory response pathway; INTERACTS WITH (R)-noradrenaline; (S)-colchicine; (S)-nicotine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Ednra; endothelin B receptor; endothelin receptor; endothelin receptor non-selective type; endothelin-B receptor; ET-B; ET-BR; Etb
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Ednrbsl  
Genetic Models: F344.AR-Ednrbsl/Hkv AR-Ednrbsl/Hkv LEH/Hkv LE.AR-Ednrbsl/Okkm AR-Ednrbsl/Okkm
Is Marker For: Strains:   DA   SI-Tg(Ednrb)Ywa   Sl   LE.AR-Ednrbsl/Okkm   AR-Ednrbsl/Okkm  
QTLs:   Scl1   BpQTLcluster12   Bp126   Gluco31  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81587,055,490 - 87,086,765 (-)NCBIGRCr8
mRatBN7.21580,640,839 - 80,672,115 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1580,643,043 - 80,672,115 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1584,622,892 - 84,651,923 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01585,745,953 - 85,774,986 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01582,673,598 - 82,702,629 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01588,004,775 - 88,036,354 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1588,006,977 - 88,036,354 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01591,500,400 - 91,531,979 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41587,893,141 - 87,898,700 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11587,908,924 - 87,914,471 (-)NCBI
Celera1579,772,740 - 79,801,760 (-)NCBICelera
RH 3.4 Map15496.21RGD
Cytogenetic Map15q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(R)-noradrenaline  (EXP)
(S)-colchicine  (EXP)
(S)-nicotine  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (EXP)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (EXP)
7,12-dimethyltetraphene  (EXP)
7-nitroindazole  (EXP)
8-bromo-3',5'-cyclic GMP  (EXP)
acadesine  (EXP)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrylamide  (EXP,ISO)
actinomycin D  (EXP)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
amphotericin B  (ISO)
angiotensin II  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrasentan  (EXP)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bosentan  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
celecoxib  (EXP)
CGP 52608  (ISO)
CGS-21680  (ISO)
chlorambucil  (ISO)
chloroprene  (EXP)
chlorpyrifos  (EXP)
choline  (ISO)
chromium atom  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
cocaine  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
Cuprizon  (EXP)
cycloheximide  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (EXP)
daunorubicin  (EXP)
Deoxycorticosterone acetate  (EXP)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
dimethyl sulfoxide  (EXP)
dioxygen  (EXP,ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
enrasentan  (ISO)
entinostat  (ISO)
ethanol  (EXP,ISO)
etoposide  (ISO)
fenoterol  (ISO)
fentanyl  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
gefitinib  (ISO)
genistein  (ISO)
gentamycin  (EXP,ISO)
hydrogen cyanide  (ISO)
Ile(5)-angiotensin II  (EXP)
indometacin  (ISO)
inulin  (ISO)
isoprenaline  (EXP)
isoquinoline-1,5-diol  (EXP)
ketoconazole  (EXP)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
malathion  (ISO)
mercury dibromide  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
mifepristone  (ISO)
MK-2206  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide  (EXP)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP)
nicotine  (EXP)
nicotinic acid  (ISO)
nimesulide  (ISO)
nitric oxide  (EXP)
nitrites  (EXP)
nitrofen  (EXP)
nitroprusside  (EXP)
Nonylphenol  (EXP)
ozone  (EXP,ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paricalcitol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
permethrin  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
phosphoramidon  (EXP)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
picrotoxin  (EXP)
pifithrin-alpha hydrobromide  (ISO)
potassium chloride  (EXP)
potassium chromate  (ISO)
potassium cyanide  (ISO)
progesterone  (ISO)
quercetin  (EXP,ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP)
rofecoxib  (ISO)
SB 203580  (EXP)
SB 431542  (ISO)
SB-239063  (EXP)
serpentine asbestos  (ISO)
sodium arsenite  (ISO)
sodium chloride  (EXP)
sorafenib  (EXP)
staurosporine  (EXP)
sulfadimethoxine  (EXP)
Tanshinone I  (EXP)
telmisartan  (EXP)
testosterone  (EXP)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
troglitazone  (ISO)
U-73122  (EXP)
udenafil  (EXP)
urethane  (ISO)
valproic acid  (ISO)
venlafaxine hydrochloride  (EXP)
vincaleukoblastine  (EXP)
vincristine  (EXP)
vorinostat  (ISO)
wedelolactone  (EXP)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aldosterone metabolic process  (ISO)
calcium ion transmembrane transport  (ISO)
calcium-mediated signaling  (ISO,ISS)
canonical Wnt signaling pathway  (ISO)
cellular response to lipopolysaccharide  (IEP)
cGMP-mediated signaling  (IMP)
chordate pharynx development  (ISO)
developmental pigmentation  (IBA,ISO)
endothelin receptor signaling pathway  (IBA,ISO)
enteric nervous system development  (ISO)
enteric smooth muscle cell differentiation  (ISO)
epithelial fluid transport  (IMP)
establishment of endothelial barrier  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
gene expression  (ISO)
heparin metabolic process  (ISO)
macrophage chemotaxis  (ISO)
melanocyte differentiation  (IDA,ISO)
negative regulation of apoptotic process  (IMP)
negative regulation of neuron maturation  (ISO)
negative regulation of protein metabolic process  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
neural crest cell migration  (ISO)
neuroblast migration  (ISO)
peripheral nervous system development  (ISO)
phospholipase C-activating G protein-coupled receptor signaling pathway  (IMP)
pigmentation  (IMP,ISO)
podocyte differentiation  (ISO)
positive regulation of canonical NF-kappaB signal transduction  (ISO)
positive regulation of cell population proliferation  (IMP)
positive regulation of cytosolic calcium ion concentration  (IDA)
positive regulation of penile erection  (IMP)
positive regulation of protein phosphorylation  (IDA)
positive regulation of urine volume  (IMP)
posterior midgut development  (ISO)
protein transmembrane transport  (ISO)
regulation of blood pressure  (IMP,ISO)
regulation of epithelial cell proliferation  (IMP)
regulation of fever generation  (IMP)
regulation of heart rate  (ISO)
regulation of pH  (ISO)
renal albumin absorption  (ISO)
renal sodium excretion  (ISO)
renal sodium ion absorption  (ISO)
renin secretion into blood stream  (ISO)
response to endothelin  (IMP)
response to lipopolysaccharide  (IMP)
response to pain  (IMP)
response to sodium phosphate  (ISO)
sodium ion homeostasis  (ISO)
vasoconstriction  (IBA,IMP,ISO)
vasodilation  (IMP)
vein smooth muscle contraction  (ISO)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Developmental changes in the functional, biochemical and molecular properties of rat bladder endothelin receptors. Afiatpour P, etal., Naunyn Schmiedebergs Arch Pharmacol. 2003 May;367(5):462-72. Epub 2003 Apr 17.
2. Mutation of the endothelin-receptor B gene in Waardenburg-Hirschsprung disease. Attie T, etal., Hum Mol Genet. 1995 Dec;4(12):2407-9.
3. ETA receptor-mediated Ca2+ signaling in thin descending limbs of Henle's loop: impairment in genetic hypertension. Bailey MA, etal., Kidney Int. 2003 Apr;63(4):1276-84.
4. Endothelin-1 receptor subtypes expression and binding in a perfused rat model of myocardial infarction. Bikhazi AB, etal., Comp Biochem Physiol C Toxicol Pharmacol. 2003 Jan;134(1):35-43.
5. Functional endothelin receptors are present on nuclei in cardiac ventricular myocytes. Boivin B, etal., J Biol Chem. 2003 Aug 1;278(31):29153-63. Epub 2003 May 19.
6. Murine and rat cavernosal responses to endothelin-1 and urotensin-II Vasoactive Peptide Symposium. Carneiro FS, etal., J Am Soc Hypertens. 2008 Nov;2(6):439-447.
7. ETA receptor-mediated Ca2+ mobilisation in H9c2 cardiac cells. Ceccarelli F, etal., Biochem Pharmacol 2003 Mar 1;65(5):783-93.
8. Interstitial deletion of the endothelin-B receptor gene in the spotting lethal (sl) rat. Ceccherini I, etal., Hum Mol Genet 1995 Nov;4(11):2089-96.
9. Effects of chronic cold exposure on the endothelin system. Chen GF and Sun Z, J Appl Physiol. 2006 May;100(5):1719-26. Epub 2005 Dec 29.
10. Endothelins as pronociceptive mediators of the rat trigeminal system: role of ETA and ETB receptors. Chichorro JG, etal., Brain Res. 2010 Jul 23;1345:73-83. Epub 2010 May 5.
11. Endothelin-1 impairs alveolar epithelial function via endothelial ETB receptor. Comellas AP, etal., Am J Respir Crit Care Med. 2009 Jan 15;179(2):113-22. Epub 2008 Oct 23.
12. Increased ET-1 and reduced ET(B) receptor expression in uremic hypertensive rats. D'Amours M, etal., Clin Exp Hypertens. 2010 Jan;32(1):61-9.
13. Lymphopenia in Ednrb-deficient rat was strongly modified by genetic background. Dang R, etal., Biomed Res. 2012;33(4):249-53.
14. QTL analysis identifies a modifier locus of aganglionosis in the rat model of Hirschsprung disease carrying Ednrb(sl) mutations. Dang R, etal., PLoS One. 2011;6(11):e27902. Epub 2011 Nov 22.
15. Genetic background strongly modifies the severity of symptoms of Hirschsprung disease, but not hearing loss in rats carrying Ednrb(sl) mutations. Dang R, etal., PLoS One. 2011;6(9):e24086. Epub 2011 Sep 7.
16. Genetic mapping of two new blood pressure quantitative trait loci in the rat by genotyping endothelin system genes. Deng AY, etal., J Clin Invest 1994 Jun;93(6):2701-9
17. Upregulation of endothelin receptors A and B in the nitrofen induced hypoplastic lung occurs early in gestation. Dingemann J, etal., Pediatr Surg Int. 2010 Jan;26(1):65-9.
18. Endotoxin causes pulmonary hypertension by upregulating smooth muscle endothelin type-B receptors: role of aldose reductase. Dschietzig T, etal., Shock. 2008 Aug;30(2):189-96.
19. Central endothelin ET(B) receptors mediate IL-1-dependent fever induced by preformed pyrogenic factor and corticotropin-releasing factor in the rat. Fabricio AS, etal., Am J Physiol Regul Integr Comp Physiol. 2006 Jan;290(1):R164-71. Epub 2005 Aug 25.
20. NAADP-induced Ca(2+ signaling in response to endothelin is via the receptor subtype B and requires the integrity of lipid rafts/caveolae. Gambara G, etal., J Cell Physiol. 2008 Aug;216(2):396-404.
21. Transgenic expression of the endothelin-B receptor prevents congenital intestinal aganglionosis in a rat model of Hirschsprung disease. Gariepy CE, etal., J Clin Invest 1998 Sep 15;102(6):1092-101.
22. Salt-sensitive hypertension in endothelin-B receptor-deficient rats. Gariepy CE, etal., J Clin Invest 2000 Apr;105(7):925-33.
23. Null mutation of endothelin receptor type B gene in spotting lethal rats causes aganglionic megacolon and white coat color. Gariepy CE, etal., Proc Natl Acad Sci U S A 1996 Jan 23;93(2):867-72.
24. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
25. LPS from Porphyromonas gingivalis increases the sensitivity of contractile response mediated by endothelin-B (ET(B)) receptors in cultured endothelium-intact rat coronary arteries. Ghorbani B, etal., Vascul Pharmacol. 2010 Nov-Dec;53(5-6):250-7. Epub 2010 Oct 1.
26. Involvement of endothelin-1 and its receptors in PGF2alpha-induced luteolysis in the rat. Girsh E and Dekel N, Mol Reprod Dev 2002 Sep;63(1):71-8.
27. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
28. Polymorphisms in genes of the endothelin system and cerebral small-vessel disease. Gormley K, etal., Stroke. 2005 Aug;36(8):1656-60. Epub 2005 Jul 7.
29. Up-regulation of endothelin receptor function and mRNA expression in airway smooth muscle cells following Sephadex-induced airway inflammation. Granstrom BW, etal., Basic Clin Pharmacol Toxicol. 2004 Jul;95(1):43-8.
30. Endothelin A and B receptors are down-regulated in the hearts of hypertensive rats. Hayzer DJ, etal., Am J Med Sci 1994 Mar;307(3):222-7.
31. ETA receptor blockade induces tubular cell proliferation and cyst growth in rats with polycystic kidney disease. Hocher B, etal., J Am Soc Nephrol. 2003 Feb;14(2):367-76.
32. QTL analysis of modifiers for pigmentary disorder in rats carrying Ednrb(sl) mutations. Huang J, etal., Sci Rep. 2016 Jan 22;6:19697. doi: 10.1038/srep19697.
33. Role of angiotensin II and endothelin-1 receptors in aging-related functional changes in rat cardiovascular system. Ishihata A and Katano Y, Ann N Y Acad Sci. 2006 May;1067:173-81.
34. Increased immunoreactivity of endothelin-1 and endothelin B receptor in human atherosclerotic lesions. A possible role in atherogenesis. Iwasa S, etal., Atherosclerosis. 1999 Sep;146(1):93-100.
35. Endothelin 1 and 3 enhance neuronal nitric oxide synthase activity through ETB receptors involving multiple signaling pathways in the rat anterior hypothalamus. Jaureguiberry MS, etal., Peptides. 2004 Jul;25(7):1133-8.
36. Dual constrictor and dilator actions of ET(B) receptors in the rat renal microcirculation: interactions with ET(A) receptors. Just A, etal., Am J Physiol Renal Physiol. 2004 Apr;286(4):F660-8. Epub 2003 Dec 16.
37. The role of ET(A) and ET(B) receptor antagonists in acute and allergic inflammation in mice. Kassuya CA, etal., Peptides. 2008 Aug;29(8):1329-37. Epub 2008 Mar 16.
38. Endothelin-B receptor activation triggers an endogenous analgesic cascade at sites of peripheral injury. Khodorova A, etal., Nat Med. 2003 Aug;9(8):1055-61. Epub 2003 Jun 29.
39. Differential effects of endothelin on activation of renal mechanosensory nerves: stimulatory in high-sodium diet and inhibitory in low-sodium diet. Kopp UC, etal., Am J Physiol Regul Integr Comp Physiol. 2006 Nov;291(5):R1545-56. Epub 2006 Jun 8.
40. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
41. Activation of ETB receptors increases superoxide levels in sympathetic ganglia in vivo. Lau YE, etal., Am J Physiol Regul Integr Comp Physiol. 2006 Jan;290(1):R90-5. Epub 2005 Sep 22.
42. Effect of pyrrolidine dithiocarbamate on hepatic vascular stress gene expression during ischemia and reperfusion. Lee CH, etal., Eur J Pharmacol. 2008 Oct 24;595(1-3):100-7. Epub 2008 Aug 9.
43. Multiple signaling pathways involved in the effect of endothelin type B receptor in rat median eminence. Mathison Y, etal., Acta Biol Hung. 2007 Jun;58(2):139-50.
44. Involvement of NO and MEK/ERK pathway in enhancement of endothelin-1-induced mesenteric artery contraction in later-stage type 2 diabetic Goto-Kakizaki rat. Matsumoto T, etal., Am J Physiol Heart Circ Physiol. 2009 May;296(5):H1388-97. Epub 2009 Mar 13.
45. Calcitonin gene-related peptide selectively relaxes contractile responses to endothelin-1 in rat mesenteric resistance arteries. Meens MJ, etal., J Pharmacol Exp Ther. 2009 Oct;331(1):87-95. Epub 2009 Jul 23.
46. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
47. Inhibitory effects of PPAR-gamma on endothelin-1-induced inflammatory pathways in vascular smooth muscle cells from normotensive and hypertensive rats. Montezano AC, etal., J Am Soc Hypertens. 2007 Mar-Apr;1(2):150-60.
48. Renal medullary ETB receptors produce diuresis and natriuresis via NOS1. Nakano D, etal., Am J Physiol Renal Physiol. 2008 May;294(5):F1205-11. Epub 2008 Feb 27.
49. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
50. Polymorphisms of the endothelin-A and -B receptor genes in relation to blood pressure and myocardial infarction: the Etude Cas-Temoins sur l'Infarctus du Myocarde (ECTIM) Study. Nicaud V, etal., Am J Hypertens. 1999 Mar;12(3):304-10.
51. Role of endothelin B receptor in the pathogenesis of ischemic acute renal failure. Nishida M, etal., J Cardiovasc Pharmacol 2002 Oct;40(4):586-93.
52. Roles of endothelin ETA and ETB receptors in the pathogenesis of monocrotaline-induced pulmonary hypertension. Nishida M, etal., J Cardiovasc Pharmacol. 2004 Aug;44(2):187-91.
53. Extrarenal ETB plays a significant role in controlling cardiovascular responses to high dietary sodium in rats. Ohkita M, etal., Hypertension. 2005 May;45(5):940-6. Epub 2005 Apr 4.
54. Endothelin-1 (ET-1) is increased in rat retina after crushing optic nerve. Oku H, etal., Curr Eye Res. 2008 Jul;33(7):611-20.
55. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
56. ET(B) receptor-deficient rats exhibit reduced contraction to ET-1 despite an increase in ET(A) receptors. Perry MG, etal., Am J Physiol Heart Circ Physiol 2001 Dec;281(6):H2680-6.
57. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
58. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
59. ETA and ETB receptor function in pancreatitis-associated microcirculatory failure, inflammation, and parenchymal injury. Plusczyk T, etal., Am J Physiol Gastrointest Liver Physiol. 2003 Jul;285(1):G145-53.
60. A missense mutation of the endothelin-B receptor gene in multigenic Hirschsprung's disease. Puffenberger EG, etal., Cell. 1994 Dec 30;79(7):1257-66.
61. GOA pipeline RGD automated data pipeline
62. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
63. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
64. Endothelin B receptor deficient transgenic rescue rats: a rescue phenomenon in the brain. Riechers CC, etal., Neuroscience. 2004;124(4):719-23.
65. Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor. Sakurai T, etal., Nature 1990 Dec 20-27;348(6303):732-5.
66. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
67. ETB receptor polymorphism is associated with airway obstruction. Taille C, etal., BMC Pulm Med. 2007 Apr 30;7:5.
68. BMPR2 mutation alters the lung macrophage endothelin-1 cascade in a mouse model and patients with heritable pulmonary artery hypertension. Talati M, etal., Am J Physiol Lung Cell Mol Physiol. 2010 Sep;299(3):L363-73. Epub 2010 Jun 18.
69. Effects of exogenous big endothelin-1 on postischemic cardiac dysfunction and norepinephrine overflow in rat hearts. Tawa M, etal., Hypertens Res. 2011 Feb;34(2):218-24. Epub 2010 Nov 4.
70. Unique endothelin receptor binding in kidneys of ETB receptor deficient rats. Taylor TA, etal., Am J Physiol Regul Integr Comp Physiol 2003 Mar;284(3):R674-81.
71. ABCD syndrome is caused by a homozygous mutation in the EDNRB gene. Verheij JB, etal., Am J Med Genet. 2002 Mar 15;108(3):223-5.
72. Deficiency in endothelin receptor B reduces proliferation of neuronal progenitors and increases apoptosis in postnatal rat cerebellum. Vidovic M, etal., Cell Mol Neurobiol. 2008 Dec;28(8):1129-38. Epub 2008 Aug 6.
73. Ischemic heart disease induces upregulation of endothelin receptor mRNA in human coronary arteries. Wackenfors A, etal., Eur J Pharmacol. 2004 Jan 19;484(1):103-9.
74. Null mutation of the endothelin receptor type B gene causes embryonic death in the GK rat. Wang J, etal., PLoS One. 2019 Jun 6;14(6):e0217132. doi: 10.1371/journal.pone.0217132. eCollection 2019.
75. Peroxisome proliferator-activated receptor-alpha activation reduces salt-dependent hypertension during chronic endothelin B receptor blockade. Williams JM, etal., Hypertension. 2005 Aug;46(2):366-71. Epub 2005 Jun 20.
76. Aberrant ETB receptor regulation of AT receptors in immortalized renal proximal tubule cells of spontaneously hypertensive rats. Zeng C, etal., Kidney Int. 2005 Aug;68(2):623-31.
77. Pentoxifylline attenuation of experimental hepatopulmonary syndrome. Zhang J, etal., J Appl Physiol. 2007 Mar;102(3):949-55. Epub 2006 Nov 16.
78. [Effect and mechanism of salvianolic acid B in attenuating elevated portal pressure in a rat model of portal hypertension induced by endothelin-1]. Zhou Y, etal., Zhong Xi Yi Jie He Xue Bao. 2007 Jan;5(1):61-4.
Additional References at PubMed
PMID:1312429   PMID:1713452   PMID:2379821   PMID:8371713   PMID:8582288   PMID:8982507   PMID:9012511   PMID:10021336   PMID:10591209   PMID:10626068   PMID:11413164   PMID:11834512  
PMID:11897624   PMID:11910302   PMID:12088756   PMID:12164874   PMID:12207323   PMID:12421649   PMID:12441350   PMID:12668144   PMID:12686728   PMID:12713865   PMID:12750545   PMID:12813000  
PMID:12919946   PMID:14988072   PMID:15194452   PMID:15280069   PMID:15311109   PMID:15322542   PMID:15344879   PMID:15464196   PMID:15761039   PMID:15838256   PMID:15838268   PMID:15838271  
PMID:15838321   PMID:15838330   PMID:15838350   PMID:15838354   PMID:15838359   PMID:15838360   PMID:15838363   PMID:16144989   PMID:16341592   PMID:16463654   PMID:16806184   PMID:16947426  
PMID:17337507   PMID:17345093   PMID:17400719   PMID:17495482   PMID:17522762   PMID:17626731   PMID:17632282   PMID:17664390   PMID:17670915   PMID:17873013   PMID:17892518   PMID:18205269  
PMID:18242601   PMID:18281380   PMID:18287215   PMID:18424628   PMID:18469849   PMID:18516102   PMID:18518881   PMID:18524860   PMID:18547994   PMID:18567602   PMID:18758505   PMID:18793415  
PMID:19111903   PMID:19157542   PMID:19196949   PMID:19297422   PMID:19353416   PMID:19535675   PMID:19628575   PMID:19767294   PMID:19945955   PMID:20008273   PMID:20026178   PMID:20399772  
PMID:20716444   PMID:20844020   PMID:21035524   PMID:21228598   PMID:21428728   PMID:21536992   PMID:21801590   PMID:22007724   PMID:22198335   PMID:22198514   PMID:22258095   PMID:22391414  
PMID:22457360   PMID:22585122   PMID:22787113   PMID:22848635   PMID:22916224   PMID:22952915   PMID:23047940   PMID:23086942   PMID:23351051   PMID:23370722   PMID:23396520   PMID:23436727  
PMID:23599626   PMID:23646960   PMID:23875673   PMID:23988741   PMID:24144054   PMID:24462674   PMID:24467585   PMID:24503339   PMID:24582810   PMID:24731444   PMID:24779608   PMID:24815227  
PMID:24914193   PMID:24918345   PMID:25091502   PMID:25232999   PMID:25772258   PMID:25806822   PMID:25891848   PMID:26022359   PMID:26232046   PMID:26318480   PMID:26459423   PMID:26528589  
PMID:26776836   PMID:27017960   PMID:27582096   PMID:27697218   PMID:28012855   PMID:28236341   PMID:28356074   PMID:28623618   PMID:28701323   PMID:28757442   PMID:29115394   PMID:29351432  
PMID:30839511   PMID:32023824   PMID:32083942   PMID:32687659   PMID:32848199   PMID:33127751   PMID:33279571   PMID:33403617   PMID:34147087   PMID:34600481   PMID:37348026   PMID:37349999  
PMID:37901475   PMID:38166688  


Genomics

Comparative Map Data
Ednrb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81587,055,490 - 87,086,765 (-)NCBIGRCr8
mRatBN7.21580,640,839 - 80,672,115 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1580,643,043 - 80,672,115 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1584,622,892 - 84,651,923 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01585,745,953 - 85,774,986 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01582,673,598 - 82,702,629 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01588,004,775 - 88,036,354 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1588,006,977 - 88,036,354 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01591,500,400 - 91,531,979 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41587,893,141 - 87,898,700 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11587,908,924 - 87,914,471 (-)NCBI
Celera1579,772,740 - 79,801,760 (-)NCBICelera
RH 3.4 Map15496.21RGD
Cytogenetic Map15q22NCBI
EDNRB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381377,895,487 - 77,975,527 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1377,895,481 - 77,975,529 (-)EnsemblGRCh38hg38GRCh38
GRCh371378,469,622 - 78,549,662 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361377,367,617 - 77,447,665 (-)NCBINCBI36Build 36hg18NCBI36
Build 341377,368,543 - 77,390,935NCBI
Celera1359,367,540 - 59,390,895 (-)NCBICelera
Cytogenetic Map13q22.3NCBI
HuRef1359,168,348 - 59,248,390 (-)NCBIHuRef
CHM1_11378,436,966 - 78,516,998 (-)NCBICHM1_1
T2T-CHM13v2.01377,120,409 - 77,200,427 (-)NCBIT2T-CHM13v2.0
Ednrb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3914104,052,055 - 104,081,764 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl14104,052,061 - 104,081,838 (-)EnsemblGRCm39 Ensembl
GRCm3814103,814,615 - 103,844,508 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl14103,814,625 - 103,844,402 (-)EnsemblGRCm38mm10GRCm38
MGSCv3714104,213,842 - 104,243,390 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3614102,700,305 - 102,729,375 (-)NCBIMGSCv36mm8
Celera14102,434,540 - 102,464,042 (-)NCBICelera
Cytogenetic Map14E2.3NCBI
cM Map1453.05NCBI
Ednrb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540429,394,164 - 29,425,358 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540429,394,253 - 29,425,358 (+)NCBIChiLan1.0ChiLan1.0
EDNRB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21479,464,042 - 79,488,264 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11378,060,299 - 78,084,570 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01359,112,349 - 59,136,615 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11378,153,026 - 78,177,281 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1378,153,020 - 78,177,286 (-)Ensemblpanpan1.1panPan2
EDNRB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12231,415,324 - 31,438,772 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2231,417,308 - 31,437,587 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2231,277,699 - 31,297,545 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02231,733,123 - 31,756,544 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2231,733,292 - 31,756,408 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12231,396,562 - 31,416,398 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02231,434,803 - 31,454,631 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02231,507,052 - 31,526,893 (-)NCBIUU_Cfam_GSD_1.0
Ednrb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945128,029,566 - 128,061,207 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365113,446,839 - 3,478,434 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365113,446,864 - 3,478,434 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EDNRB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1150,072,554 - 50,102,884 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11150,073,300 - 50,102,879 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21154,689,465 - 54,718,898 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EDNRB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1356,969,493 - 56,993,719 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl356,969,101 - 56,992,731 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604613,190,167 - 13,214,545 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ednrb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475122,459,584 - 22,491,606 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475122,459,613 - 22,491,409 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ednrb
108 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:222
Count of miRNA genes:153
Interacting mature miRNAs:170
Transcripts:ENSRNOT00000014747
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731177Uae26Urinary albumin excretion QTL 262.40.025urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1567588667101769107Rat
1576315Schws6Schwannoma susceptibility QTL 60.0069nervous system integrity trait (VT:0010566)post-insult time of death (CMO:0002005)155380615298806152Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)154063126898288169Rat
1549844Bss7Bone structure and strength QTL 76.4femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1575788062101769107Rat
61477Aia4Adjuvant induced arthritis QTL 43joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)155559608991365858Rat
2300326Plaw1Placental weight QTL 1150.005placenta mass (VT:0004257)placenta wet weight (CMO:0002088)1568327165100062518Rat
70182BpQTLcluster12Blood pressure QTL cluster 123.53arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)157369065795018120Rat
70155Gcs1Gastric cancer susceptibility QTL13.8stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)1576306099101769107Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)152788577486257085Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1581555Eae19Experimental allergic encephalomyelitis QTL 194.7nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)157630609990088744Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
631655Bp126Blood pressure QTL 1264arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1558156477101769107Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
631516Gluco31Glucose level QTL 317blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)155559608995018120Rat
1331724Bp223Blood pressure QTL 2233.53715arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)157369051895018228Rat
1641889Colcr6Colorectal carcinoma resistance QTL 62.90.0126intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)157369051899794247Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
2317055Aia10Adjuvant induced arthritis QTL 103.41joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1575788062101769107Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat

Markers in Region
D15Mco2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21580,640,428 - 80,640,727 (+)MAPPERmRatBN7.2
mRatBN7.21580,640,501 - 80,640,727 (+)MAPPERmRatBN7.2
Rnor_6.01588,004,438 - 88,004,663NCBIRnor6.0
Rnor_6.01588,004,206 - 88,004,663NCBIRnor6.0
Rnor_5.01591,500,063 - 91,500,288UniSTSRnor5.0
Rnor_5.01591,499,831 - 91,500,288UniSTSRnor5.0
RGSC_v3.41587,890,620 - 87,890,845UniSTSRGSC3.4
RGSC_v3.41587,890,619 - 87,890,845RGDRGSC3.4
RGSC_v3.11587,906,399 - 87,906,625RGD
Celera1579,770,219 - 79,770,444UniSTS
Cytogenetic Map15q21-q22UniSTS
D15Mco3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21580,645,554 - 80,645,729 (+)MAPPERmRatBN7.2
Rnor_6.01588,009,405 - 88,009,579NCBIRnor6.0
Rnor_5.01591,505,030 - 91,505,204UniSTSRnor5.0
RGSC_v3.41587,895,670 - 87,895,844UniSTSRGSC3.4
Celera1579,775,226 - 79,775,400UniSTS
Cytogenetic Map15q21-q22UniSTS
D15Wox13  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21580,648,147 - 80,648,395 (+)MAPPERmRatBN7.2
Rnor_6.01588,012,000 - 88,012,247NCBIRnor6.0
Rnor_5.01591,507,625 - 91,507,872UniSTSRnor5.0
RGSC_v3.41587,898,265 - 87,898,512UniSTSRGSC3.4
Celera1579,777,821 - 79,778,067UniSTS
Cytogenetic Map15q21-q22UniSTS
D15Ulb3  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81587,061,214 - 87,061,500 (+)Marker Load Pipeline
mRatBN7.21580,646,566 - 80,646,850 (+)MAPPERmRatBN7.2
Rnor_6.01588,010,417 - 88,010,700NCBIRnor6.0
Rnor_5.01591,506,042 - 91,506,325UniSTSRnor5.0
RGSC_v3.41587,896,682 - 87,896,965UniSTSRGSC3.4
Celera1579,776,238 - 79,776,521UniSTS
Cytogenetic Map15q21-q22UniSTS
PMC24270P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21580,643,379 - 80,643,591 (+)MAPPERmRatBN7.2
Rnor_6.01588,007,314 - 88,007,525NCBIRnor6.0
Rnor_5.01591,502,939 - 91,503,150UniSTSRnor5.0
RGSC_v3.41587,893,496 - 87,893,707UniSTSRGSC3.4
Celera1579,773,095 - 79,773,306UniSTS
Cytogenetic Map15q21-q22UniSTS
AA818970  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21580,670,939 - 80,671,119 (+)MAPPERmRatBN7.2
Rnor_6.01588,035,179 - 88,035,358NCBIRnor6.0
Rnor_5.01591,530,804 - 91,530,983UniSTSRnor5.0
Celera1579,800,585 - 79,800,764UniSTS
RH 3.4 Map15498.61UniSTS
Cytogenetic Map15q21-q22UniSTS
EDNRB-2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21580,648,543 - 80,649,972 (+)MAPPERmRatBN7.2
Rnor_6.01588,012,396 - 88,013,824NCBIRnor6.0
Rnor_5.01591,508,021 - 91,509,449UniSTSRnor5.0
Celera1579,778,216 - 79,779,644UniSTS
Cytogenetic Map15q21-q22UniSTS


Related Rat Strains
The following Strains have been annotated to Ednrb
AR-Ednrbsl/Okkm     DA     LE.AR-Ednrbsl/Okkm     SI-Tg(Ednrb)Ywa     Sl    


Genetic Models
This gene Ednrb is modified in the following models/strains:
F344.AR-Ednrbsl/Hkv     AR-Ednrbsl/Hkv     LEH/Hkv     LE.AR-Ednrbsl/Okkm     AR-Ednrbsl/Okkm    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000014747   ⟹   ENSRNOP00000014747
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1580,643,043 - 80,672,115 (-)Ensembl
Rnor_6.0 Ensembl1588,006,977 - 88,036,354 (-)Ensembl
RefSeq Acc Id: NM_017333   ⟹   NP_059029
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81587,057,673 - 87,086,765 (-)NCBI
mRatBN7.21580,643,025 - 80,672,115 (-)NCBI
Rnor_6.01588,006,959 - 88,036,354 (-)NCBI
Rnor_5.01591,500,400 - 91,531,979 (-)NCBI
RGSC_v3.41587,893,141 - 87,898,700 (-)RGD
Celera1579,772,740 - 79,801,760 (-)RGD
Sequence:
RefSeq Acc Id: XM_006252431   ⟹   XP_006252493
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81587,055,490 - 87,086,257 (-)NCBI
mRatBN7.21580,640,839 - 80,671,537 (-)NCBI
Rnor_6.01588,004,775 - 88,036,106 (-)NCBI
Rnor_5.01591,500,400 - 91,531,979 (-)NCBI
Sequence:
RefSeq Acc Id: NP_059029   ⟸   NM_017333
- Peptide Label: precursor
- UniProtKB: P21451 (UniProtKB/Swiss-Prot),   A6HUA5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006252493   ⟸   XM_006252431
- Peptide Label: isoform X1
- UniProtKB: P21451 (UniProtKB/Swiss-Prot),   A6HUA5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000014747   ⟸   ENSRNOT00000014747
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P21451-F1-model_v2 AlphaFold P21451 1-442 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699864
Promoter ID:EPDNEW_R10387
Type:single initiation site
Name:Ednrb_1
Description:endothelin receptor type B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01588,036,356 - 88,036,416EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2536 AgrOrtholog
BioCyc Gene G2FUF-12665 BioCyc
Ensembl Genes ENSRNOG00000010997 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055008002 UniProtKB/Swiss-Prot
  ENSRNOG00060005817 UniProtKB/Swiss-Prot
  ENSRNOG00065006642 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000014747.6 UniProtKB/Swiss-Prot
  ENSRNOT00055013494 UniProtKB/Swiss-Prot
  ENSRNOT00060009647 UniProtKB/Swiss-Prot
  ENSRNOT00065010267 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Endthln_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ETB_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_endothelin_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:50672 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene Ednrb ENTREZGENE
PANTHER ENDOTHELIN RECEPTOR TYPE B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB EDNRB RGD
PhenoGen Ednrb PhenoGen
PRINTS ENDOTHELINBR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENDOTHELINR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010997 RatGTEx
  ENSRNOG00055008002 RatGTEx
  ENSRNOG00060005817 RatGTEx
  ENSRNOG00065006642 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6HUA5 ENTREZGENE, UniProtKB/TrEMBL
  EDNRB_RAT UniProtKB/Swiss-Prot
  F2W8B2_RAT UniProtKB/TrEMBL
  P21451 ENTREZGENE
  Q9R1M2_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Ednrb  endothelin receptor type B      Symbol and Name updated 629477 APPROVED
2003-03-19 Ednrb  endothelin receptor type B  Etb  endothelin receptor  Data merged from RGD:621128 628472 PROVISIONAL
2002-08-07 Etb  endothelin receptor      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Ednrb  endothelin receptor type B      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease mutation of this gene in humans a leads to congental aganglionic megacolon or Hirschsprung disease, participates in deoxycorticosterone acetate (DOCA)-salt-induced hypertension, cardiovascular hypertrophy and renal damage 628459
gene_disease mutation of this gene in humans a leads to congental aganglionic megacolon or Hirschsprung disease, participates in deoxycorticosterone acetate (DOCA)-salt-induced hypertension, cardiovascular hypertrophy and renal damage 628515
gene_disease mutation of this gene in humans a leads to congental aganglionic megacolon or Hirschsprung disease, participates in deoxycorticosterone acetate (DOCA)-salt-induced hypertension, cardiovascular hypertrophy and renal damage 628516
gene_expression expressed in vascular and nonvascular tissues of the lung, brain and gut, mRNA first detected in the neural crest cells and in the wall of the forgut diverticulum. 628459
gene_expression expressed in vascular and nonvascular tissues of the lung, brain and gut, mRNA first detected in the neural crest cells and in the wall of the forgut diverticulum. 628515
gene_expression expressed in vascular and nonvascular tissues of the lung, brain and gut, mRNA first detected in the neural crest cells and in the wall of the forgut diverticulum. 628516
gene_expression not expressed in spontaneously hypertensive rat hearts but was expressed in salt-hypertensive sensitive and resistant rats fed a high-salt diet 1358986
gene_function induces inositol phosphate accumulation and calcium flux 61059
gene_mutations_overexpression deletion in this gene stops the receptor expression hence elevates endothelin 1 628459
gene_mutations_overexpression deletion in this gene stops the receptor expression hence elevates endothelin 1 628515
gene_mutations_overexpression deletion in this gene stops the receptor expression hence elevates endothelin 1 628516
gene_process involved in the development of two neural crest derived cells, epidermal melanocytes and entric neurons 628459
gene_process involved in the development of two neural crest derived cells, epidermal melanocytes and entric neurons 628515
gene_process involved in the development of two neural crest derived cells, epidermal melanocytes and entric neurons 628516
gene_process may be involved in congenital aganglionic megacolon and pigmentation abnormalities 628459
gene_process may be involved in congenital aganglionic megacolon and pigmentation abnormalities 628515
gene_process may be involved in congenital aganglionic megacolon and pigmentation abnormalities 628516