Ednra (endothelin receptor type A) - Rat Genome Database

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Gene: Ednra (endothelin receptor type A) Rattus norvegicus
Symbol: Ednra
Name: endothelin receptor type A
RGD ID: 2535
Description: Enables endothelin receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; cellular response to mechanical stimulus; and glomerular filtration. Located in T-tubule and nuclear membrane. Used to study hypertension; myocardial infarction; portal hypertension; pulmonary emphysema; and pulmonary hypertension. Biomarker of several diseases, including hyperhomocysteinemia; impotence; obstructive sleep apnea; renal fibrosis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in hypertension (multiple); lung disease; mandibulofacial dysostosis with alopecia; migraine; and obstructive sleep apnea. Orthologous to human EDNRA (endothelin receptor type A); PARTICIPATES IN endothelin signaling pathway; inflammatory response pathway; Rho/Rac/Cdc42 mediated signaling pathway; INTERACTS WITH (R)-noradrenaline; 11-deoxycorticosterone; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ENDOR; endothelin A receptor; endothelin-1 receptor; endothelin-1 receptor-like; ET-A; ET-AR; Eta; LOC100366209; RATENDOR; RGD1559432
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Is Marker For: QTLs:   Scl12  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81947,137,360 - 47,207,961 (+)NCBIGRCr8
mRatBN7.21930,233,540 - 30,303,727 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1930,233,571 - 30,297,049 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1937,065,939 - 37,130,121 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01937,719,814 - 37,783,991 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01939,968,901 - 40,033,091 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01933,928,356 - 33,991,703 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1933,928,356 - 33,991,703 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01944,812,252 - 44,874,904 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41932,042,366 - 32,108,153 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11932,051,058 - 32,110,066 (+)NCBI
Celera1929,719,589 - 29,778,843 (+)NCBICelera
Cytogenetic Map19q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-noradrenaline  (EXP)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
11-deoxycorticosterone  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-naphthylamine  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide  (EXP)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acadesine  (EXP)
acetamide  (EXP)
acrolein  (ISO)
actinomycin D  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
agmatine  (ISO)
aldehydo-D-glucose  (ISO)
aldosterone  (EXP)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ambrisentan  (ISO)
aminoguanidine  (EXP)
amitrole  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antirheumatic drug  (ISO)
apocynin  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
aspartame  (ISO)
atorvastatin calcium  (EXP)
atrasentan  (EXP,ISO)
atrazine  (EXP)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bosentan  (EXP,ISO)
BQ 123  (EXP,ISO)
BQ 485  (EXP)
cadmium dichloride  (EXP)
calcium atom  (EXP)
calcium(0)  (EXP)
cantharidin  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
celecoxib  (EXP)
chromium(6+)  (ISO)
cisplatin  (ISO)
cocaine  (EXP,ISO)
Cuprizon  (EXP)
cycloheximide  (EXP)
cyclosporin A  (EXP)
D-glucose  (ISO)
daunorubicin  (EXP)
decabromodiphenyl ether  (EXP)
Deoxycorticosterone acetate  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (EXP,ISO)
diethyl malate  (ISO)
dimethyl sulfoxide  (EXP)
dioxygen  (EXP,ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
enrasentan  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
fluvastatin  (EXP)
folic acid  (ISO)
fructose  (EXP,ISO)
fulvestrant  (ISO)
furan  (EXP)
glucose  (ISO)
hexadecanoic acid  (ISO)
hydrogen cyanide  (ISO)
inulin  (ISO)
isoprenaline  (EXP,ISO)
isoquinoline-1,5-diol  (EXP)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
losartan  (EXP)
Magnolol  (EXP)
methimazole  (EXP)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
mifepristone  (EXP)
monocrotaline  (EXP)
N(gamma)-nitro-L-arginine methyl ester  (EXP)
nicotine  (ISO)
nitrofen  (EXP,ISO)
ouabain  (EXP)
ozone  (EXP,ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
phosphoramidon  (EXP)
pirinixic acid  (ISO)
potassium chloride  (ISO)
potassium cyanide  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
Ptaquiloside  (ISO)
quartz  (ISO)
raloxifene  (ISO)
reactive oxygen species  (EXP)
rebaudioside A  (ISO)
resveratrol  (EXP)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 203580  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
simvastatin  (EXP)
sodium arsenite  (ISO)
sodium chloride  (EXP,ISO)
steviol  (ISO)
stevioside  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
superoxide  (EXP)
tacrolimus hydrate  (EXP)
tamoxifen  (ISO)
Tanshinone I  (EXP)
telmisartan  (EXP)
temozolomide  (ISO)
testosterone  (EXP)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
valproic acid  (ISO)
valsartan  (EXP)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  (IEA,ISO)
angiogenesis  (ISO)
aorta development  (IEA,ISO)
artery smooth muscle contraction  (IEA,ISO)
atrial cardiac muscle tissue development  (IEA,ISO)
axon extension  (IEA,ISO)
axon guidance  (ISO)
axonogenesis involved in innervation  (IEA,ISO)
blood vessel remodeling  (IEA,ISO)
branching involved in blood vessel morphogenesis  (IEA,ISO)
calcium ion transmembrane transport  (IEA,ISO)
canonical Wnt signaling pathway  (IEA,ISO)
cardiac chamber formation  (IEA,ISO)
cardiac neural crest cell migration involved in outflow tract morphogenesis  (IEA,ISO)
cellular response to follicle-stimulating hormone stimulus  (IEA,ISO)
cellular response to human chorionic gonadotropin stimulus  (IEA,ISO)
cellular response to luteinizing hormone stimulus  (IEA,ISO)
cellular response to mechanical stimulus  (IMP)
cellular response to oxidative stress  (IEA,ISO)
cranial skeletal system development  (IEA,ISO)
developmental pigmentation  (IBA)
embryonic heart tube development  (IEA,ISO)
embryonic skeletal system development  (IEA,ISO)
endothelin receptor signaling pathway  (IBA,IEA,ISO)
endothelin receptor signaling pathway involved in heart process  (IEA,ISO)
enteric nervous system development  (IEA)
establishment of endothelial barrier  (IEA,ISO)
face development  (IEA,ISO)
fibroblast proliferation  (IMP)
gene expression  (IEA,ISO)
glomerular endothelium development  (IEA,ISO)
glomerular filtration  (IEA,IMP,ISO)
glomerulus development  (ISO)
head development  (ISO)
heart development  (ISO)
heart process  (ISO)
heparin metabolic process  (IEA,ISO)
histamine secretion  (IMP)
in utero embryonic development  (IEA,ISO)
intracellular calcium ion homeostasis  (IEA,ISO)
left ventricular cardiac muscle tissue morphogenesis  (IEA,ISO)
maternal process involved in parturition  (IEP)
meiotic cell cycle process involved in oocyte maturation  (IEA,ISO)
mesenchymal cell apoptotic process  (IEA,ISO)
middle ear morphogenesis  (IEA,ISO)
mitochondrion organization  (IEA,ISO)
mitotic cell cycle  (IEA,ISO)
negative regulation of apoptotic process  (IMP)
neural crest cell development  (ISO)
neural crest cell differentiation  (ISO)
neural crest cell fate commitment  (IEA,ISO)
neuromuscular process  (IEA,ISO)
neuron projection development  (ISO)
neuron remodeling  (IEA,ISO)
noradrenergic neuron differentiation  (IEA,ISO)
norepinephrine metabolic process  (IEA,ISO)
pharyngeal arch artery morphogenesis  (IEA,ISO)
phospholipase C-activating G protein-coupled receptor signaling pathway  (IMP)
podocyte apoptotic process  (IEA,ISO)
podocyte differentiation  (IEA,ISO)
positive regulation of calcium ion transport  (IMP)
positive regulation of canonical NF-kappaB signal transduction  (IEA,ISO)
positive regulation of cell population proliferation  (IMP)
positive regulation of cytosolic calcium ion concentration  (IDA)
positive regulation of ERK1 and ERK2 cascade  (IMP)
positive regulation of kidney development  (IMP)
positive regulation of neutrophil chemotaxis  (IMP)
positive regulation of odontogenesis  (IMP)
positive regulation of protein phosphorylation  (IMP)
positive regulation of release of sequestered calcium ion into cytosol  (IMP)
protein kinase A signaling  (IEA,ISO)
protein kinase C-activating G protein-coupled receptor signaling pathway  (IMP)
protein transmembrane transport  (IEA,ISO)
regulation of blood pressure  (IEA,ISO)
regulation of epithelial cell proliferation  (IMP)
regulation of glucose transmembrane transport  (IEA,ISO)
regulation of heart rate  (IEA,ISO)
regulation of protein localization to cell leading edge  (IEA,ISO)
renal albumin absorption  (IEA,ISO)
renal sodium ion absorption  (IEA,ISO)
respiratory gaseous exchange by respiratory system  (IEA,ISO)
response to acetylcholine  (IEA,ISO)
response to amphetamine  (IEA,ISO)
response to hypoxia  (IEA,ISO)
response to lipopolysaccharide  (IMP)
response to organic cyclic compound  (IEP)
response to wounding  (IEA,ISO)
Rho protein signal transduction  (IMP)
semaphorin-plexin signaling pathway involved in axon guidance  (IEA,ISO)
smooth muscle cell proliferation  (IMP)
sodium ion homeostasis  (IEA,ISO)
sympathetic nervous system development  (IEA,ISO)
sympathetic neuron axon guidance  (IEA,ISO)
thyroid gland development  (IEA,ISO)
vascular associated smooth muscle cell development  (IEA,ISO)
vasoconstriction  (IBA,IEA,IMP,ISO)

Cellular Component

Molecular Function
endothelin receptor activity  (IBA,IDA,IEA,ISO,TAS)
protein binding  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References - curated
# Reference Title Reference Citation
1. Developmental changes in the functional, biochemical and molecular properties of rat bladder endothelin receptors. Afiatpour P, etal., Naunyn Schmiedebergs Arch Pharmacol. 2003 May;367(5):462-72. Epub 2003 Apr 17.
2. Inhibition of endothelin-1 receptors improves impaired nitric oxide synthase-dependent dilation of cerebral arterioles in type-1 diabetic rats. Arrick DM and Mayhan WG, Microcirculation. 2010 Aug;17(6):439-46.
3. ETA receptor-mediated Ca2+ signaling in thin descending limbs of Henle's loop: impairment in genetic hypertension. Bailey MA, etal., Kidney Int. 2003 Apr;63(4):1276-84.
4. Major role for hypoxia inducible factor-1 and the endothelin system in promoting myocardial infarction and hypertension in an animal model of obstructive sleep apnea. Belaidi E, etal., J Am Coll Cardiol. 2009 Apr 14;53(15):1309-17.
5. Association of EDNRA, but not WNK4 or FKBP1B, polymorphisms with essential hypertension. Benjafield AV, etal., Clin Genet. 2003 Nov;64(5):433-8.
6. Endothelin-1 receptor subtypes expression and binding in a perfused rat model of myocardial infarction. Bikhazi AB, etal., Comp Biochem Physiol C Toxicol Pharmacol. 2003 Jan;134(1):35-43.
7. Functional endothelin receptors are present on nuclei in cardiac ventricular myocytes. Boivin B, etal., J Biol Chem. 2003 Aug 1;278(31):29153-63. Epub 2003 May 19.
8. Genetic polymorphisms in endothelin-receptor-subtype-a-gene as susceptibility factor for obstructive sleep apnea syndrome. Buck D, etal., Sleep Med. 2010 Feb;11(2):213-7. Epub 2010 Jan 18.
9. Murine and rat cavernosal responses to endothelin-1 and urotensin-II Vasoactive Peptide Symposium. Carneiro FS, etal., J Am Soc Hypertens. 2008 Nov;2(6):439-447.
10. ETA receptor-mediated Ca2+ mobilisation in H9c2 cardiac cells. Ceccarelli F, etal., Biochem Pharmacol 2003 Mar 1;65(5):783-93.
11. Effects of chronic cold exposure on the endothelin system. Chen GF and Sun Z, J Appl Physiol. 2006 May;100(5):1719-26. Epub 2005 Dec 29.
12. Endothelin-1 receptor antagonists prevent the development of pulmonary emphysema in rats. Chen Y, etal., Eur Respir J. 2010 Apr;35(4):904-12. Epub 2009 Nov 6.
13. Endothelins as pronociceptive mediators of the rat trigeminal system: role of ETA and ETB receptors. Chichorro JG, etal., Brain Res. 2010 Jul 23;1345:73-83. Epub 2010 May 5.
14. Endothelin-1 impairs alveolar epithelial function via endothelial ETB receptor. Comellas AP, etal., Am J Respir Crit Care Med. 2009 Jan 15;179(2):113-22. Epub 2008 Oct 23.
15. Increased ET-1 and reduced ET(B) receptor expression in uremic hypertensive rats. D'Amours M, etal., Clin Exp Hypertens. 2010 Jan;32(1):61-9.
16. EDNRA variants associate with smooth muscle mRNA levels, cell proliferation rates, and cystic fibrosis pulmonary disease severity. Darrah R, etal., Physiol Genomics. 2010 Mar 3;41(1):71-7. Epub 2009 Dec 22.
17. Increased endothelin-1 reactivity and endothelial dysfunction in carotid arteries from rats with hyperhomocysteinemia. de Andrade CR, etal., Br J Pharmacol. 2009 Jun;157(4):568-80. Epub 2009 Apr 9.
18. Age-related changes in endothelin-1 receptor subtypes in rat heart. Del Ry S, etal., Exp Aging Res. 2008 Jul-Sep;34(3):251-66.
19. Upregulation of endothelin receptors A and B in the nitrofen induced hypoplastic lung occurs early in gestation. Dingemann J, etal., Pediatr Surg Int. 2010 Jan;26(1):65-9.
20. Enhanced expression of renal endothelin-converting enzyme-1 and endothelin-A-receptor mRNA in rats with interstitial fibrosis following ureter ligation. Feldman DL, etal., J Cardiovasc Pharmacol. 2000 Nov;36(5 Suppl 1):S255-9.
21. Ambrisentan for the treatment of pulmonary arterial hypertension: results of the ambrisentan in pulmonary arterial hypertension, randomized, double-blind, placebo-controlled, multicenter, efficacy (ARIES) study 1 and 2. Galie N, etal., Circulation. 2008 Jun 10;117(23):3010-9. Epub 2008 May 27.
22. NAADP-induced Ca(2+ signaling in response to endothelin is via the receptor subtype B and requires the integrity of lipid rafts/caveolae. Gambara G, etal., J Cell Physiol. 2008 Aug;216(2):396-404.
23. Transgenic expression of the endothelin-B receptor prevents congenital intestinal aganglionosis in a rat model of Hirschsprung disease. Gariepy CE, etal., J Clin Invest 1998 Sep 15;102(6):1092-101.
24. Null mutation of endothelin receptor type B gene in spotting lethal rats causes aganglionic megacolon and white coat color. Gariepy CE, etal., Proc Natl Acad Sci U S A 1996 Jan 23;93(2):867-72.
25. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
26. Involvement of endothelin-1 and its receptors in PGF2alpha-induced luteolysis in the rat. Girsh E and Dekel N, Mol Reprod Dev 2002 Sep;63(1):71-8.
27. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
28. Polymorphisms in genes of the endothelin system and cerebral small-vessel disease. Gormley K, etal., Stroke. 2005 Aug;36(8):1656-60. Epub 2005 Jul 7.
29. Endothelin A and B receptors are down-regulated in the hearts of hypertensive rats. Hayzer DJ, etal., Am J Med Sci 1994 Mar;307(3):222-7.
30. A polymorphism in the endothelin-A receptor gene predicts survival in patients with idiopathic dilated cardiomyopathy. Herrmann S, etal., Eur Heart J. 2001 Oct;22(20):1948-53.
31. ETA receptor blockade induces tubular cell proliferation and cyst growth in rats with polycystic kidney disease. Hocher B, etal., J Am Soc Nephrol. 2003 Feb;14(2):367-76.
32. Regulation of endothelin-converting enzyme 1 in nephrotic syndrome in rats. Ikebe M, etal., Nephron Exp Nephrol. 2003;94(4):e137-45.
33. Dual constrictor and dilator actions of ET(B) receptors in the rat renal microcirculation: interactions with ET(A) receptors. Just A, etal., Am J Physiol Renal Physiol. 2004 Apr;286(4):F660-8. Epub 2003 Dec 16.
34. The role of ET(A) and ET(B) receptor antagonists in acute and allergic inflammation in mice. Kassuya CA, etal., Peptides. 2008 Aug;29(8):1329-37. Epub 2008 Mar 16.
35. Endothelin-1 induces organ-specific histamine liberation and neutrophil granulocyte accumulation in the rat. Kaszaki J, etal., Inflamm Res. 2008 Aug;57(8):396-402.
36. Peripheral mechanisms of erectile dysfunction in a rat model of chronic cocaine use. Kendirci M, etal., Eur Urol. 2007 Aug;52(2):555-63. Epub 2007 Mar 20.
37. Cloning and functional expression of a vascular smooth muscle endothelin 1 receptor. Lin HY, etal., Proc Natl Acad Sci U S A 1991 Apr 15;88(8):3185-9.
38. Constriction of rat extra-splenic veins to lipopolysaccharide involves endothelin-1. Mansart A, etal., Naunyn Schmiedebergs Arch Pharmacol. 2010 Jun;381(6):555-62. Epub 2010 Apr 16.
39. Involvement of NO and MEK/ERK pathway in enhancement of endothelin-1-induced mesenteric artery contraction in later-stage type 2 diabetic Goto-Kakizaki rat. Matsumoto T, etal., Am J Physiol Heart Circ Physiol. 2009 May;296(5):H1388-97. Epub 2009 Mar 13.
40. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
41. Endothelin-a receptor in rat skeletal muscle microvasculature. Mitchell D, etal., Microvasc Res. 2002 Jul;64(1):179-85.
42. Inhibitory effects of PPAR-gamma on endothelin-1-induced inflammatory pathways in vascular smooth muscle cells from normotensive and hypertensive rats. Montezano AC, etal., J Am Soc Hypertens. 2007 Mar-Apr;1(2):150-60.
43. Mechanical stretch induced interleukin-18 (IL-18) expression through Angiotensin subtype 1 receptor (AT1R) and endothelin-1 in cardiomyocytes. Naka T, etal., Prep Biochem Biotechnol. 2008;38(2):201-12.
44. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
45. Polymorphisms of the endothelin-A and -B receptor genes in relation to blood pressure and myocardial infarction: the Etude Cas-Temoins sur l'Infarctus du Myocarde (ECTIM) Study. Nicaud V, etal., Am J Hypertens. 1999 Mar;12(3):304-10.
46. Roles of endothelin ETA and ETB receptors in the pathogenesis of monocrotaline-induced pulmonary hypertension. Nishida M, etal., J Cardiovasc Pharmacol. 2004 Aug;44(2):187-91.
47. Thrombin-stimulated proliferation is mediated by endothelin-1 in cultured rat gingival fibroblasts. Ohuchi N, etal., Fundam Clin Pharmacol. 2010 Aug;24(4):501-8. Epub 2009 Oct 30.
48. Endothelin-1 (ET-1) is increased in rat retina after crushing optic nerve. Oku H, etal., Curr Eye Res. 2008 Jul;33(7):611-20.
49. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
50. ET(B) receptor-deficient rats exhibit reduced contraction to ET-1 despite an increase in ET(A) receptors. Perry MG, etal., Am J Physiol Heart Circ Physiol 2001 Dec;281(6):H2680-6.
51. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
52. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
53. ETA and ETB receptor function in pancreatitis-associated microcirculatory failure, inflammation, and parenchymal injury. Plusczyk T, etal., Am J Physiol Gastrointest Liver Physiol. 2003 Jul;285(1):G145-53.
54. Involvement of central endothelin receptors in neonatal morphine withdrawal. Puppala BL, etal., Exp Biol Med (Maywood). 2006 Jun;231(6):1157-60.
55. Role of endothelin (ETA) receptors in neonatal morphine withdrawal. Puppala BL, etal., Peptides. 2006 Jun;27(6):1514-9. Epub 2005 Nov 15.
56. Regulation of endothelin-A receptor sensitivity by cyclic adenosine monophosphate in rat hepatic stellate cells. Reinehr R, etal., Hepatology 2002 Oct;36(4 Pt 1):861-73.
57. GOA pipeline RGD automated data pipeline
58. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
59. Endothelin, PAF and thromboxane A2 in allergic pulmonary hyperreactivity in mice. Richter M, etal., Prostaglandins Leukot Essent Fatty Acids. 2007 May;76(5):299-308. Epub 2007 Apr 19.
60. Localization of functional endothelin receptor signaling complexes in cardiac transverse tubules. Robu VG, etal., J Biol Chem. 2003 Nov 28;278(48):48154-61. Epub 2003 Sep 12.
61. Tumor endothelin-1 enhances metastatic colonization of the lung in mouse xenograft models of bladder cancer. Said N, etal., J Clin Invest. 2011 Jan 4;121(1):132-47. doi: 10.1172/JCI42912. Epub 2010 Dec 22.
62. Endothelin receptor A-specific stimulation of glomerular inflammation and injury in a streptozotocin-induced rat model of diabetes. Saleh MA, etal., Diabetologia. 2010 Dec 30.
63. Endothelin-1 increases glomerular permeability and inflammation independent of blood pressure in the rat. Saleh MA, etal., Hypertension. 2010 Nov;56(5):942-9. Epub 2010 Sep 7.
64. Effects of endothelin ETA receptor antagonism on granulocyte and lymphocyte accumulation in LPS-induced inflammation. Sampaio AL, etal., J Leukoc Biol. 2004 Jul;76(1):210-6. Epub 2004 Apr 23.
65. Effect of YM598, a selective endothelin ETA receptor antagonist, on endothelin-1-induced bone formation. Someya A, etal., Eur J Pharmacol. 2006 Aug 14;543(1-3):14-20. Epub 2006 Jun 27.
66. Cooperative effect of angiotensin AT(1) and endothelin ET(A) receptor antagonism limits the brain damage after ischemic stroke in rat. Stenman E, etal., Eur J Pharmacol. 2007 Sep 10;570(1-3):142-8. Epub 2007 Jun 9.
67. BMPR2 mutation alters the lung macrophage endothelin-1 cascade in a mouse model and patients with heritable pulmonary artery hypertension. Talati M, etal., Am J Physiol Lung Cell Mol Physiol. 2010 Sep;299(3):L363-73. Epub 2010 Jun 18.
68. Role of endogenous endothelin-1 in post-ischemic cardiac dysfunction and norepinephrine overflow in rat hearts. Tawa M, etal., Eur J Pharmacol. 2008 Sep 4;591(1-3):182-8. Epub 2008 Jun 14.
69. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
70. Association between migraine and endothelin type A receptor (ETA -231 A/G) gene polymorphism. Tzourio C, etal., Neurology 2001 May 22;56(10):1273-7.
71. Early endothelin-A receptor blockade decreases blood pressure and ameliorates end-organ damage in homozygous Ren-2 rats. Vaneckova I, etal., Hypertension. 2005 Oct;46(4):969-74. Epub 2005 Sep 12.
72. Ischemic heart disease induces upregulation of endothelin receptor mRNA in human coronary arteries. Wackenfors A, etal., Eur J Pharmacol. 2004 Jan 19;484(1):103-9.
73. Endothelin-1 regulates proliferative responses, both alone and synergistically with PDGF, in rat tracheal smooth muscle cells. Yahiaoui L, etal., Cell Physiol Biochem. 2006;17(1-2):37-46. Epub 2006 Feb 7.
74. Inhibition of endothelin-1 and hypoxia-induced pulmonary pressor responses in the rat by a novel selective endothelin-A receptor antagonist, di-n-butylaminocarbamyl-L-leucyl-D-tryptophanyl-D-4-chloro-Phe. Yan LD, etal., J Cardiovasc Pharmacol. 2010 Sep;56(3):246-54.
75. Role of Endothelin-1/Endothelin-A receptor-mediated signaling pathway in the aortic arch patterning in mice. Yanagisawa H, etal., J Clin Invest 1998 Jul 1;102(1):22-33.
76. Endothelin A receptor blockade influences apoptosis and cellular proliferation in the developing rat kidney. Yoo KH, etal., J Korean Med Sci. 2009 Feb;24(1):138-45. Epub 2009 Feb 28.
77. Cholesterol dependence of vascular ERK1/2 activation and growth in response to stretch: role of endothelin-1. Zeidan A, etal., Arterioscler Thromb Vasc Biol. 2003 Sep 1;23(9):1528-34. Epub 2003 Aug 7.
78. [Effect and mechanism of salvianolic acid B in attenuating elevated portal pressure in a rat model of portal hypertension induced by endothelin-1]. Zhou Y, etal., Zhong Xi Yi Jie He Xue Bao. 2007 Jan;5(1):61-4.
Additional References at PubMed
PMID:1312429   PMID:8982507   PMID:9449664   PMID:9826706   PMID:10626068   PMID:11546805   PMID:11882629   PMID:11897624   PMID:11910302   PMID:12464391   PMID:12668144   PMID:12686728  
PMID:12851419   PMID:14993193   PMID:15306564   PMID:15327783   PMID:15344879   PMID:15563533   PMID:15585964   PMID:15664398   PMID:15668985   PMID:15838253   PMID:15838256   PMID:15838268  
PMID:15838271   PMID:15838315   PMID:15838319   PMID:15838321   PMID:15838330   PMID:15838346   PMID:15838359   PMID:15838360   PMID:15838361   PMID:15838363   PMID:15915003   PMID:15928212  
PMID:16463654   PMID:16712977   PMID:16736156   PMID:16763077   PMID:16947426   PMID:17060503   PMID:17312275   PMID:17333248   PMID:17379848   PMID:17400719   PMID:17495482   PMID:17626731  
PMID:17639881   PMID:17670915   PMID:17892519   PMID:18205269   PMID:18281380   PMID:18287215   PMID:18424628   PMID:18462720   PMID:18469849   PMID:18515645   PMID:18518881   PMID:18524860  
PMID:18567602   PMID:18823320   PMID:19029977   PMID:19104001   PMID:19157542   PMID:19628575   PMID:19748906   PMID:20307649   PMID:20450830   PMID:20628427   PMID:20844020   PMID:21801590  
PMID:21801594   PMID:21801595   PMID:22258095   PMID:22365956   PMID:22406300   PMID:22407503   PMID:22569294   PMID:22952915   PMID:23047940   PMID:23351051   PMID:23396520   PMID:23436727  
PMID:23946290   PMID:24144054   PMID:24157978   PMID:24449761   PMID:24486390   PMID:24582810   PMID:24636620   PMID:24815227   PMID:24918345   PMID:25088996   PMID:25091502   PMID:25255392  
PMID:25891848   PMID:26459423   PMID:26528589   PMID:26776836   PMID:27697218   PMID:27997891   PMID:28012855   PMID:28412414   PMID:28579512   PMID:28757442   PMID:29329779   PMID:29360807  
PMID:31075232   PMID:31398465   PMID:32023824   PMID:33098940   PMID:33127751   PMID:33339902   PMID:34894846   PMID:38166688  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81947,137,360 - 47,207,961 (+)NCBIGRCr8
mRatBN7.21930,233,540 - 30,303,727 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1930,233,571 - 30,297,049 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1937,065,939 - 37,130,121 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01937,719,814 - 37,783,991 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01939,968,901 - 40,033,091 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01933,928,356 - 33,991,703 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1933,928,356 - 33,991,703 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01944,812,252 - 44,874,904 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41932,042,366 - 32,108,153 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11932,051,058 - 32,110,066 (+)NCBI
Celera1929,719,589 - 29,778,843 (+)NCBICelera
Cytogenetic Map19q11NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh384147,481,097 - 147,544,954 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4147,480,917 - 147,544,954 (+)EnsemblGRCh38hg38GRCh38
GRCh374148,402,249 - 148,466,106 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364148,621,575 - 148,685,555 (+)NCBINCBI36Build 36hg18NCBI36
Build 344148,759,734 - 148,823,710NCBI
Celera4145,723,204 - 145,787,202 (+)NCBICelera
Cytogenetic Map4q31.22-q31.23NCBI
HuRef4144,129,326 - 144,193,179 (+)NCBIHuRef
CHM1_14148,380,418 - 148,444,465 (+)NCBICHM1_1
T2T-CHM13v2.04150,805,228 - 150,869,037 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39878,389,658 - 78,451,081 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl878,389,660 - 78,451,093 (-)EnsemblGRCm39 Ensembl
GRCm38877,663,029 - 77,724,452 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl877,663,031 - 77,724,464 (-)EnsemblGRCm38mm10GRCm38
MGSCv37880,186,928 - 80,248,351 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36880,559,140 - 80,620,420 (-)NCBIMGSCv36mm8
Celera881,946,457 - 82,007,225 (-)NCBICelera
Cytogenetic Map8C1NCBI
cM Map836.63NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554283,062,303 - 3,114,761 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554283,062,303 - 3,114,761 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v23145,349,200 - 145,415,071 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14145,714,744 - 145,780,615 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04139,815,336 - 139,879,600 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14151,476,353 - 151,536,497 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4151,476,356 - 151,536,497 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11545,823,472 - 45,878,527 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1545,823,560 - 45,876,463 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1546,219,878 - 46,270,714 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01546,496,528 - 46,553,179 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1546,496,502 - 46,554,470 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11545,768,959 - 45,819,737 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01545,864,678 - 45,915,481 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01546,175,034 - 46,225,816 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440530144,512,782 - 44,568,451 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365351,949,941 - 2,005,910 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365351,950,117 - 2,005,786 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl881,209,327 - 81,276,853 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1881,210,750 - 81,279,053 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2886,293,177 - 86,319,721 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1793,980,983 - 94,043,863 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl793,985,797 - 94,042,296 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603773,678,428 - 73,748,330 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046248536,302,751 - 6,360,089 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248536,298,406 - 6,362,353 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Ednra
518 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:386
Count of miRNA genes:211
Interacting mature miRNAs:276
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131963836Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
61407Scl12Serum cholesterol level QTL 120.001blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)191392640130303727Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)191511459834521833Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
61328Eae8Experimental allergic encephalomyelitis QTL 84nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)192481604133061905Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)192481797839654489Rat
1354600Salc2Saline consumption QTL 29.910.001drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)192753020737947399Rat
1354607Gmadr1Adrenal mass QTL 15.83adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)192753020737947399Rat
1354633Bw28Body weight QTL 286.04body mass (VT:0001259)body weight (CMO:0000012)192753020737947399Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01944,873,858 - 44,874,084NCBIRnor5.0
RGSC_v3.41932,107,108 - 32,107,333RGDRGSC3.4
RGSC_v3.11932,111,934 - 32,112,159RGD
Cytogenetic Map19q11UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21930,296,755 - 30,296,970 (+)MAPPERmRatBN7.2
Rnor_6.01933,991,410 - 33,991,624NCBIRnor6.0
Rnor_5.01944,874,611 - 44,874,825UniSTSRnor5.0
RGSC_v3.41932,107,860 - 32,108,074UniSTSRGSC3.4
Celera1929,778,550 - 29,778,764UniSTS
Cytogenetic Map19q11UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21930,295,676 - 30,295,891 (+)MAPPERmRatBN7.2
Rnor_6.01933,990,331 - 33,990,545NCBIRnor6.0
Rnor_5.01944,873,532 - 44,873,746UniSTSRnor5.0
RGSC_v3.41932,106,781 - 32,106,995UniSTSRGSC3.4
Celera1929,777,471 - 29,777,685UniSTS
RH 3.4 Map19231.2UniSTS
Cytogenetic Map19q11UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 37 6 20 37 11
Low 3 6 57 41 19 41 8 11 68 15 4 8
Below cutoff


RefSeq Acc Id: ENSRNOT00000058162   ⟹   ENSRNOP00000054967
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1930,233,692 - 30,297,049 (+)Ensembl
Rnor_6.0 Ensembl1933,928,356 - 33,991,703 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000078395   ⟹   ENSRNOP00000072294
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1930,237,576 - 30,294,075 (+)Ensembl
Rnor_6.0 Ensembl1933,932,532 - 33,988,729 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000078701   ⟹   ENSRNOP00000069839
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1930,237,576 - 30,294,075 (+)Ensembl
Rnor_6.0 Ensembl1933,932,532 - 33,988,729 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000080095   ⟹   ENSRNOP00000071866
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1933,931,719 - 33,988,877 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000080317   ⟹   ENSRNOP00000071667
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1930,233,571 - 30,297,049 (+)Ensembl
Rnor_6.0 Ensembl1933,932,558 - 33,988,196 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000091985   ⟹   ENSRNOP00000073963
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1930,237,576 - 30,294,075 (+)Ensembl
Rnor_6.0 Ensembl1933,932,532 - 33,988,729 (+)Ensembl
RefSeq Acc Id: NM_012550   ⟹   NP_036682
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
GRCr81947,137,924 - 47,201,285 (+)NCBI
mRatBN7.21930,233,692 - 30,297,049 (+)NCBI
Rnor_6.01933,928,356 - 33,991,703 (+)NCBI
Rnor_5.01944,812,252 - 44,874,904 (+)NCBI
RGSC_v3.41932,042,366 - 32,108,153 (+)RGD
Celera1929,719,589 - 29,778,843 (+)RGD
RefSeq Acc Id: XM_039097468   ⟹   XP_038953396
Rat AssemblyChrPosition (strand)Source
GRCr81947,137,360 - 47,201,285 (+)NCBI
mRatBN7.21930,233,540 - 30,293,865 (+)NCBI
RefSeq Acc Id: XR_005496613
Rat AssemblyChrPosition (strand)Source
GRCr81947,137,360 - 47,207,961 (+)NCBI
mRatBN7.21930,233,543 - 30,303,727 (+)NCBI
RefSeq Acc Id: NP_036682   ⟸   NM_012550
- Peptide Label: precursor
- UniProtKB: P26684 (UniProtKB/Swiss-Prot),   A0A0G2JSX5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000071667   ⟸   ENSRNOT00000080317
RefSeq Acc Id: ENSRNOP00000071866   ⟸   ENSRNOT00000080095
RefSeq Acc Id: ENSRNOP00000072294   ⟸   ENSRNOT00000078395
RefSeq Acc Id: ENSRNOP00000054967   ⟸   ENSRNOT00000058162
RefSeq Acc Id: ENSRNOP00000073963   ⟸   ENSRNOT00000091985
RefSeq Acc Id: ENSRNOP00000069839   ⟸   ENSRNOT00000078701
RefSeq Acc Id: XP_038953396   ⟸   XM_039097468
- Peptide Label: isoform X1
- UniProtKB: P26684 (UniProtKB/Swiss-Prot),   A1Y2B8 (UniProtKB/TrEMBL)
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P26684-F1-model_v2 AlphaFold P26684 1-426 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2535 AgrOrtholog
BioCyc Gene G2FUF-5916 BioCyc
Ensembl Genes ENSRNOG00000012721 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00055008127 UniProtKB/Swiss-Prot
  ENSRNOG00060012663 UniProtKB/Swiss-Prot
  ENSRNOG00065010420 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000058162 ENTREZGENE
  ENSRNOT00000058162.4 UniProtKB/TrEMBL
  ENSRNOT00000078395.2 UniProtKB/TrEMBL
  ENSRNOT00000078701.2 UniProtKB/TrEMBL
  ENSRNOT00000080317.2 UniProtKB/TrEMBL
  ENSRNOT00000091985.2 UniProtKB/TrEMBL
  ENSRNOT00055013770 UniProtKB/Swiss-Prot
  ENSRNOT00060021549 UniProtKB/Swiss-Prot
  ENSRNOT00065016885 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Endthln_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ETA_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24326 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ednra PhenoGen
  ENDOTHELINR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012721 RatGTEx
  ENSRNOG00055008127 RatGTEx
  ENSRNOG00060012663 RatGTEx
  ENSRNOG00065010420 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC215722
  A0A0G2K118_RAT UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-03-29 Ednra  endothelin receptor type A  LOC100366209  endothelin-1 receptor-like  Data merged from RGD:2324049 737654 PROVISIONAL
2013-03-29 Ednra  endothelin receptor type A  RGD1559432  RGD1559432  Data merged from RGD:1559432 737654 PROVISIONAL
2010-05-06 LOC100366209  endothelin-1 receptor-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 RGD1559432  RGD1559432   RGD1559432_predicted  RGD1559432 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1559432_predicted  RGD1559432 (predicted)  LOC498937  LOC498937  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498937  LOC498937      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Ednra  Endothelin receptor type A      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in vascular and nonvascular tissues 628459
gene_expression expressed in vascular and nonvascular tissues 628515
gene_expression expressed in vascular and nonvascular tissues 628516
gene_expression not expressed in Spontaneously hypertensive rat hearts but was expressed in salt-hypertensive sensitive and resistant rats fed a high-salt diet 1358986
gene_product member of the endothelian family 628516