Edn1 (endothelin 1) - Rat Genome Database

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Gene: Edn1 (endothelin 1) Rattus norvegicus
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Symbol: Edn1
Name: endothelin 1
RGD ID: 2532
Description: Enables endothelin A receptor binding activity and endothelin B receptor binding activity. Involved in several processes, including cellular response to cytokine stimulus; regulation of secretion by cell; and response to corticosteroid. Located in several cellular components, including Weibel-Palade body; basal part of cell; and rough endoplasmic reticulum lumen. Used to study adult respiratory distress syndrome; coronary artery disease; membranoproliferative glomerulonephritis; metabolic acidosis; and portal hypertension. Biomarker of several diseases, including artery disease (multiple); heart disease (multiple); kidney failure (multiple); lung disease (multiple); and nephritis (multiple). Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); bronchial disease (multiple); obesity; obstructive sleep apnea; and rheumatoid arthritis. Orthologous to human EDN1 (endothelin 1); PARTICIPATES IN inflammatory response pathway; endothelin signaling pathway; hypoxia inducible factor pathway; INTERACTS WITH (+)-catechin; (R)-noradrenaline; 1,3-dinitrobenzene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: endothelin-1; ET-1; Et1; PPET1; preproendothelin-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   SD   F344.OLETF-(D17Mgh4-Edn1)/Tj  
QTLs:   Niddm32  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81722,660,799 - 22,666,687 (-)NCBIGRCr8
mRatBN7.21722,454,924 - 22,460,812 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1722,454,420 - 22,460,885 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1722,330,779 - 22,336,694 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01723,934,458 - 23,940,375 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01722,266,095 - 22,271,993 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01722,136,814 - 22,143,745 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1722,137,324 - 22,143,324 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01724,117,499 - 24,124,188 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41728,303,886 - 28,309,775 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11728,306,726 - 28,312,616 (-)NCBI
Celera1722,134,975 - 22,140,901 (-)NCBICelera
Cytogenetic Map17p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute Lung Injury  (ISO)
adult respiratory distress syndrome  (IDA,IEP,ISO)
Albuminuria  (IEP)
angle-closure glaucoma  (ISO)
anterolateral myocardial infarction  (ISO)
aortic atherosclerosis  (ISO)
aspiration pneumonia  (IEP)
asthma  (ISO)
atherosclerosis  (ISO)
atrial fibrillation  (ISO)
Auriculocondylar Syndrome  (ISO)
Auriculocondylar Syndrome 3  (ISO)
autosomal dominant polycystic kidney disease  (ISO)
basal cell carcinoma  (ISO)
Behcet's disease  (ISO)
Bradycardia  (ISO)
brain ischemia  (IEP)
bronchiolitis obliterans  (ISO)
bronchopulmonary dysplasia  (IEP)
Cardiac Arrhythmias  (ISO)
Cardiac Fibrosis  (IDA)
Cardiomegaly  (IEP,ISO)
cardiomyopathy  (ISO)
Cardiovascular Abnormalities  (ISO)
cardiovascular system disease  (ISO)
cartilage disease  (ISO)
cerebrovascular disease  (ISO)
Chronic Bronchitis  (ISO)
chronic obstructive pulmonary disease  (ISO)
chronic rhinitis  (ISO)
Chronic Tubulointerstitial Nephropathy  (IEP)
congenital heart disease  (ISO)
congestive heart failure  (IEP,ISO)
coronary artery disease  (IMP,ISO)
coronary stenosis  (ISO)
Craniofacial Abnormalities  (ISO)
cystic fibrosis  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (IEP,ISO)
Diaphragmatic Hernia  (ISO)
dilated cardiomyopathy  (ISO)
Dyspnea  (ISO)
end stage renal disease  (IEP)
Endotoxemia  (IEP)
exfoliation syndrome  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (IDA,IEP,ISO)
Experimental Liver Cirrhosis  (ISO)
focal segmental glomerulosclerosis  (ISO)
gastrointestinal system disease  (ISO)
genetic disease  (ISO)
heart disease  (IEP)
hepatopulmonary syndrome  (IEP)
hepatorenal syndrome  (ISO)
Hyperalgesia  (ISO)
Hypercapnia  (IEP,ISO)
Hypercholesterolemia  (ISO)
Hyperoxia  (IEP)
hypertension  (IEP,ISO)
hypertrophic cardiomyopathy  (IEP)
Hypertrophy  (ISO)
hypogonadism  (IEP)
Hypotension  (ISO)
impotence  (IEP,ISO)
Inflammation  (ISO)
intermediate coronary syndrome  (ISO)
intracranial aneurysm  (ISO)
kidney disease  (ISO)
kidney failure  (IEP,ISO)
Left Ventricular Hypertrophy  (IDA,IEP,ISO)
Lewy body dementia  (ISO)
liver cirrhosis  (IEP)
low tension glaucoma  (ISO)
major depressive disorder  (ISO)
membranoproliferative glomerulonephritis  (IEP,IMP)
metabolic acidosis  (IDA)
middle cerebral artery infarction  (ISO)
multiple sclerosis  (ISO)
myocardial infarction  (IEP,ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (IEP,ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
neovascular glaucoma  (ISO)
neovascular inflammatory vitreoretinopathy  (ISO)
nephritis  (IEP)
nephrosis  (IEP,ISO)
nephrotic syndrome  (ISO)
obesity  (ISO)
obstructive sleep apnea  (IEP,ISO)
optic nerve disease  (ISO)
Optic Nerve Injuries  (IEP)
Oral Ulcer  (ISO)
ovarian carcinoma  (ISO)
overactive bladder syndrome  (ISO)
Pain  (ISO)
Parkinson's disease  (ISO)
peptic ulcer disease  (ISO)
pneumonia  (ISO)
Pneumoperitoneum  (IEP)
portal hypertension  (IDA)
pre-eclampsia  (ISO)
Pregnancy-Induced Hypertension  (ISO)
Premature Birth  (ISO)
Presbycusis  (ISO)
primary open angle glaucoma  (ISO)
pulmonary embolism  (IEP)
pulmonary fibrosis  (IEP,ISO)
pulmonary hypertension  (IEP,ISO)
Question Mark Ears, Isolated  (ISO)
renal artery disease  (IEP)
Reperfusion Injury  (IEP,ISO)
retinal degeneration  (ISO)
retinal detachment  (ISO)
retinitis pigmentosa  (ISO)
rheumatoid arthritis  (ISO)
Sepsis  (IEP)
Slow Coronary Flow  (ISO)
Stroke  (ISO)
Subarachnoid Hemorrhage  (ISO)
systemic scleroderma  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (IEP,ISO)
uremia  (IEP)
ureteral obstruction  (IEP,ISO)
Urinary Retention  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP,ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-noradrenaline  (EXP)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
11-deoxycorticosterone  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
1D-myo-inositol 1,4,5-trisphosphate  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (EXP)
2-butoxyethanol  (ISO)
2-tert-butylhydroquinone  (ISO)
3',5'-cyclic GMP  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxy-TEMPO  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
5-formyltetrahydrofolic acid  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
7-NITROINDAZOLE  (EXP)
8-bromo-3',5'-cyclic GMP  (EXP,ISO)
acetamide  (EXP)
acetylcholine  (EXP)
acrolein  (ISO)
actinomycin D  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
agmatine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (EXP)
all-trans-retinoic acid  (EXP,ISO)
alpha-Zearalanol  (ISO)
aminoguanidine  (EXP)
amlodipine  (ISO)
ammonium chloride  (EXP)
ampicillin  (ISO)
andrographolide  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apocynin  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
atenolol  (ISO)
atorvastatin calcium  (ISO)
atrasentan  (EXP)
atropine  (ISO)
Azoxymethane  (ISO)
Bardoxolone methyl  (ISO)
belinostat  (ISO)
benazepril  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-carotene  (ISO)
beta-lapachone  (ISO)
bezafibrate  (EXP,ISO)
bilirubin IXalpha  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
bosentan  (EXP,ISO)
BQ 123  (EXP,ISO)
BQ 485  (EXP)
buta-1,3-diene  (ISO)
Butylbenzyl phthalate  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
caesium chloride  (ISO)
caffeine  (EXP)
Calcimycin  (EXP)
calcitriol  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
Calphostin C  (EXP)
Candesartan cilexetil  (EXP)
capsaicin  (ISO)
carbon atom  (EXP)
carbon monoxide  (EXP,ISO)
carbon nanotube  (ISO)
carvedilol  (EXP,ISO)
CGS-21680  (ISO)
chelerythrine  (EXP)
chenodeoxycholic acid  (EXP)
chetomin  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
chrysin  (ISO)
cicaprost  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP,ISO)
coenzyme Q10  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
cylindrospermopsin  (ISO)
cytarabine  (ISO)
D-glucose  (EXP,ISO)
dantrolene  (EXP)
dapsone  (ISO)
daunorubicin  (EXP)
Deoxycorticosterone acetate  (EXP)
desferrioxamine B  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diallyl disulfide  (ISO)
diarsenic trioxide  (ISO)
dibenziodolium  (EXP,ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
diethyl phthalate  (EXP)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dimethylarsinic acid  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (EXP,ISO)
diprotium oxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
dydrogesterone  (ISO)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (ISO)
elemental carbon  (EXP)
enalapril  (EXP)
enalaprilat dihydrate  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (EXP,ISO)
etoposide  (ISO)
fenofibrate  (EXP,ISO)
fluoranthene  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
furan  (EXP)
geldanamycin  (ISO)
gemcitabine  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
Gingerenone A  (ISO)
glucose  (EXP,ISO)
glyburide  (EXP)
glycidol  (EXP)
glycoursodeoxycholic acid  (ISO)
GW 4064  (EXP)
heparin  (EXP,ISO)
hexadecanoic acid  (ISO)
histamine  (ISO)
homocysteine  (ISO)
hydralazine  (EXP)
hydrochlorothiazide  (EXP)
hydrogen chloride  (EXP)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (ISO)
hydroquinone  (ISO)
ICI 118551  (ISO)
indometacin  (EXP,ISO)
iodixanol  (EXP)
iopromide  (EXP)
irbesartan  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
iron(III) citrate  (ISO)
isoprenaline  (EXP)
isoquinoline-1,5-diol  (EXP)
isorhamnetin  (EXP)
isosorbide dinitrate  (ISO)
ivermectin  (ISO)
KT 5823  (EXP)
L-ascorbic acid  (ISO)
L-mimosine  (EXP,ISO)
lactiflorin  (EXP)
lamivudine  (ISO)
leflunomide  (ISO)
leukotriene C4  (ISO)
levamisole  (ISO)
linalool  (ISO)
linoleic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lisinopril dihydrate  (ISO)
losartan  (EXP,ISO)
LY294002  (EXP)
Magnolol  (EXP)
malathion  (ISO)
manganese(II) chloride  (EXP)
Meglumine sodium amidotrizoate  (EXP)
melphalan  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
metformin  (EXP,ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate  (ISO)
methyl beta-cyclodextrin  (ISO)
methylarsonic acid  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
metoprolol  (EXP)
mevalonic acid  (ISO)
Mibefradil  (EXP)
microcystin-LR  (ISO)
MK-2206  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
monocrotaline  (EXP)
montelukast  (EXP)
N(gamma)-nitro-L-arginine methyl ester  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP)
naphthalene  (ISO)
nebivolol  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
nicotinic acid-adenine dinucleotide phosphate  (ISO)
nifedipine  (EXP)
nimesulide  (EXP)
nisoldipine  (ISO)
nitric oxide  (EXP,ISO)
nitrofen  (EXP,ISO)
nitrogen dioxide  (ISO)
nitroglycerin  (EXP,ISO)
nitroprusside  (EXP)
Nutlin-3  (ISO)
ochratoxin A  (ISO)
octadecanoic acid  (ISO)
oleic acid  (ISO)
Olmesartan medoxomil  (EXP)
olodaterol  (ISO)
orotic acid  (EXP)
oroxylin A  (EXP)
ouabain  (EXP,ISO)
Oxotremorine  (ISO)
ozone  (EXP,ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
paricalcitol  (EXP)
PD123319  (EXP)
phenethyl caffeate  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP,ISO)
phenylmercury acetate  (ISO)
PhIP  (EXP)
phosgene  (EXP)
phosphoramide mustard  (EXP)
phosphoramidon  (EXP)
picrotoxin  (EXP)
pifithrin-alpha hydrobromide  (ISO)
potassium atom  (ISO)
potassium chloride  (EXP)
potassium chromate  (ISO)
pravastatin  (EXP,ISO)
prazosin  (EXP)
progesterone  (EXP,ISO)
propofol  (EXP,ISO)
prostaglandin E2  (EXP,ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
quinapril hydrochloride  (ISO)
reactive oxygen species  (EXP,ISO)
rebaudioside A  (ISO)
RES-701-1  (EXP)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
Ro 31-8220  (EXP)
rolipram  (EXP)
rotenone  (EXP,ISO)
ruxolitinib  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-methyl-L-thiocitrulline  (EXP)
S-nitroso-N-acetyl-D-penicillamine  (EXP)
SB 203580  (EXP,ISO)
SB 431542  (ISO)
sevoflurane  (EXP)
sildenafil citrate  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium atom  (ISO)
sodium chloride  (EXP)
sodium dodecyl sulfate  (ISO)
sorafenib  (EXP)
stattic  (EXP)
staurosporine  (EXP)
steviol  (ISO)
stevioside  (ISO)
stilbene-4,4'-diol  (ISO)
streptozocin  (EXP,ISO)
Sucralfate  (EXP)
sulfur dioxide  (EXP,ISO)
sunitinib  (ISO)
superoxide  (EXP,ISO)
tacrolimus hydrate  (EXP)
tamibarotene  (ISO)
tamoxifen  (ISO)
Tanshinone I  (EXP)
tauroursodeoxycholic acid  (ISO)
telmisartan  (EXP)
temozolomide  (ISO)
tenofovir disoproxil fumarate  (ISO)
teprenone  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetracosanoic acid  (ISO)
tetraphene  (ISO)
Theaflavin 3,3'-digallate  (ISO)
theophylline  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
thymidine  (ISO)
tiotropium bromide  (ISO)
Tiron  (ISO)
titanium dioxide  (ISO)
torcetrapib  (EXP)
trans-caffeic acid  (ISO)
trans-stilbene-4,4'-diol  (ISO)
triadimefon  (ISO)
tributylstannane  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
troglitazone  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
tyrphostin AG 1478  (EXP,ISO)
U-73122  (EXP)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
ursolic acid  (ISO)
valproic acid  (ISO)
valsartan  (EXP)
vanadyl sulfate  (ISO)
verapamil  (ISO)
vinclozolin  (EXP)
water  (ISO)
wortmannin  (ISO)
Y-27632  (EXP)
zafirlukast  (ISO)
zidovudine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  (ISO)
artery smooth muscle contraction  (IDA,ISO)
axon extension  (ISO)
axon guidance  (ISO)
axonogenesis involved in innervation  (ISO)
blood vessel morphogenesis  (ISO)
body fluid secretion  (ISO)
branching involved in blood vessel morphogenesis  (ISO)
calcium ion transmembrane transport  (ISO)
calcium-mediated signaling  (ISO)
cAMP/PKA signal transduction  (ISO)
canonical Wnt signaling pathway  (ISO)
cardiac neural crest cell migration involved in outflow tract morphogenesis  (ISO)
cartilage development  (ISO)
cell surface receptor signaling pathway  (ISO)
cell-cell signaling  (ISO)
cellular response to calcium ion  (IEP)
cellular response to fatty acid  (IEP)
cellular response to follicle-stimulating hormone stimulus  (ISO)
cellular response to glucocorticoid stimulus  (IEP)
cellular response to human chorionic gonadotropin stimulus  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to hypoxia  (IEP)
cellular response to interleukin-1  (IEP)
cellular response to luteinizing hormone stimulus  (ISO)
cellular response to mineralocorticoid stimulus  (IEP)
cellular response to peptide hormone stimulus  (IEP)
cellular response to transforming growth factor beta stimulus  (IEP)
cellular response to tumor necrosis factor  (IEP)
cellular response to type II interferon  (IEP)
cellular response to xenobiotic stimulus  (IEP)
dorsal/ventral pattern formation  (ISO)
embryonic heart tube development  (ISO)
endothelin receptor signaling pathway  (ISO,ISS)
endothelin receptor signaling pathway involved in heart process  (ISO)
epithelial fluid transport  (IDA)
ERK1 and ERK2 cascade  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
gene expression  (ISO)
glomerular endothelium development  (ISO)
glomerular filtration  (ISO)
heart development  (ISO)
heart process  (ISO)
histamine secretion  (IDA)
in utero embryonic development  (ISO)
intracellular calcium ion homeostasis  (IBA,ISO)
intracellular signal transduction  (IDA)
MAPK cascade  (ISO)
maternal process involved in parturition  (IEP)
meiotic cell cycle process involved in oocyte maturation  (ISO)
membrane depolarization  (IMP)
middle ear morphogenesis  (ISO)
mitochondrion organization  (ISO)
negative regulation of gene expression  (IDA)
negative regulation of hormone secretion  (IDA)
negative regulation of protein metabolic process  (ISO)
negative regulation of smooth muscle cell apoptotic process  (IDA)
negative regulation of transcription by RNA polymerase II  (ISO)
neural crest cell development  (ISO)
neural crest cell differentiation  (ISO)
neural crest cell fate commitment  (ISO)
neuron projection development  (ISO)
neutrophil chemotaxis  (ISO)
nitric oxide transport  (ISO)
noradrenergic neuron differentiation  (ISO)
obsolete negative regulation of nitric-oxide synthase biosynthetic process  (ISO)
peptide hormone secretion  (ISO)
pharyngeal arch artery morphogenesis  (ISO)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
phospholipase C-activating G protein-coupled receptor signaling pathway  (ISO)
phospholipase D-activating G protein-coupled receptor signaling pathway  (ISO)
podocyte differentiation  (ISO)
positive regulation of artery morphogenesis  (ISO)
positive regulation of calcium-mediated signaling  (ISO)
positive regulation of canonical NF-kappaB signal transduction  (ISO)
positive regulation of cardiac muscle hypertrophy  (ISO)
positive regulation of cation channel activity  (ISO)
positive regulation of cell growth involved in cardiac muscle cell development  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (IDA,ISO)
positive regulation of cell size  (ISO)
positive regulation of chemokine-mediated signaling pathway  (ISO)
positive regulation of cytosolic calcium ion concentration  (IDA)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of heart rate  (ISO)
positive regulation of hormone secretion  (ISO)
positive regulation of JNK cascade  (ISO)
positive regulation of MAP kinase activity  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of mitotic nuclear division  (ISO)
positive regulation of neutrophil chemotaxis  (IDA)
positive regulation of non-canonical NF-kappaB signal transduction  (IDA)
positive regulation of odontogenesis  (IDA)
positive regulation of prostaglandin secretion  (IDA)
positive regulation of prostaglandin-endoperoxide synthase activity  (ISO)
positive regulation of protein localization to nucleus  (ISO,ISS)
positive regulation of renal sodium excretion  (ISO)
positive regulation of sarcomere organization  (ISO)
positive regulation of signaling receptor activity  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of smooth muscle contraction  (IBA,IDA,IMP,ISO)
positive regulation of transcription by RNA polymerase II  (IDA,ISO)
positive regulation of urine volume  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (IDA)
prostaglandin biosynthetic process  (ISO)
protein kinase C deactivation  (ISO)
protein phosphorylation  (ISO)
regulation of blood pressure  (IMP,ISO)
regulation of D-glucose transmembrane transport  (ISO)
regulation of pH  (ISO)
regulation of systemic arterial blood pressure by endothelin  (IBA,ISO)
regulation of vasoconstriction  (IEA)
renal sodium ion absorption  (ISO)
respiratory gaseous exchange by respiratory system  (ISO)
response to activity  (IEP)
response to amino acid  (IEP)
response to amphetamine  (ISO)
response to dexamethasone  (IEP)
response to hypoxia  (IEP,ISO)
response to leptin  (IEP)
response to lipopolysaccharide  (IEP)
response to muscle stretch  (IEP)
response to nicotine  (IEP)
response to ozone  (IEP)
response to prostaglandin F  (IEP)
response to salt  (IEP)
response to testosterone  (IEP)
response to transforming growth factor beta  (IEP)
response to xenobiotic stimulus  (IEP)
rhythmic excitation  (ISO)
semaphorin-plexin signaling pathway involved in axon guidance  (ISO)
skeletal system development  (ISO)
smooth muscle contraction  (ISO)
superoxide anion generation  (IDA)
sympathetic neuron axon guidance  (ISO)
thyroid gland development  (ISO)
transcription by RNA polymerase II  (ISO)
vasoconstriction  (IDA,ISO)
vein smooth muscle contraction  (IBA,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
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97. Preproendothelin-1 expression is negatively regulated by IFNgamma during hepatic stellate cell activation. Li T, etal., Am J Physiol Gastrointest Liver Physiol. 2012 May 1;302(9):G948-57. doi: 10.1152/ajpgi.00359.2011. Epub 2012 Feb 2.
98. Involvement of tissue transglutaminase in endothelin 1-induced hypertrophy in cultured neonatal rat cardiomyocytes. Li X, etal., Hypertension. 2009 Oct;54(4):839-44. Epub 2009 Jul 27.
99. The role of endothelin-1 and the endothelin B receptor in the pathogenesis of hepatopulmonary syndrome in the rat. Ling Y, etal., Hepatology. 2004 Jun;39(6):1593-602.
100. Carvedilol and lacidipine prevent cardiac hypertrophy and endothelin-1 gene overexpression after aortic banding. Massart PE, etal., Hypertension. 1999 Dec;34(6):1197-201.
101. Involvement of NO and MEK/ERK pathway in enhancement of endothelin-1-induced mesenteric artery contraction in later-stage type 2 diabetic Goto-Kakizaki rat. Matsumoto T, etal., Am J Physiol Heart Circ Physiol. 2009 May;296(5):H1388-97. Epub 2009 Mar 13.
102. Exaggerated vascular and renal pathology in endothelin-B receptor-deficient rats with deoxycorticosterone acetate-salt hypertension. Matsumura Y, etal., Circulation 2000 Nov 28;102(22):2765-73.
103. Comparison of the cardiovascular and neural activity of endothelin-1, -2, -3 and respective proendothelins: effects of phosphoramidon and thiorphan. Mattera GG, etal., Br J Pharmacol. 1993 Sep;110(1):331-7.
104. Endothelins stimulate deoxyribonucleic acid synthesis and cell proliferation in rat adrenal zona glomerulosa, acting through an endothelin A receptor coupled with protein kinase C- and tyrosine kinase-dependent signaling pathways. Mazzocchi G, etal., Endocrinology. 1997 Jun;138(6):2333-7.
105. Regulation of endothelin-1 by angiopoietin-1: implications for inflammation. McCarter SD, etal., Exp Biol Med (Maywood). 2006 Jun;231(6):985-91.
106. Calcitonin gene-related peptide selectively relaxes contractile responses to endothelin-1 in rat mesenteric resistance arteries. Meens MJ, etal., J Pharmacol Exp Ther. 2009 Oct;331(1):87-95. Epub 2009 Jul 23.
107. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
108. Progressive retinal degeneration in transgenic mice with overexpression of endothelin-1 in vascular endothelial cells. Mi XS, etal., Invest Ophthalmol Vis Sci. 2012 Jul 20;53(8):4842-51. doi: 10.1167/iovs.12-9999.
109. Inhibitory effects of PPAR-gamma on endothelin-1-induced inflammatory pathways in vascular smooth muscle cells from normotensive and hypertensive rats. Montezano AC, etal., J Am Soc Hypertens. 2007 Mar-Apr;1(2):150-60.
110. Plasma endothelin-1 levels, pulmonary hypertension, and lung fibrosis in patients with systemic sclerosis. Morelli S, etal., Am J Med. 1995 Sep;99(3):255-60.
111. Transcriptional regulation of pre-pro-endothelin-1 gene by glucocorticoids in vascular smooth muscle cells. Morin C, etal., Biochem Biophys Res Commun. 1998 Mar 17;244(2):583-7.
112. Role of ET(A) and ET(B) endothelin receptors on endothelin-1-induced potentiation of nociceptive and thermal hyperalgesic responses evoked by capsaicin in rats. Motta EM, etal., Neurosci Lett. 2009 Jul 3;457(3):146-50. Epub 2009 Mar 21.
113. Endogenous plasma endothelin concentrations and coronary circulation in patients with mild dilated cardiomyopathy. Mundhenke M, etal., Heart. 1999 Mar;81(3):278-84.
114. Effects of unoprostone on phosphorylated extracellular signal-regulated kinase expression in endothelin-1-induced retinal and optic nerve damage. Munemasa Y, etal., Vis Neurosci. 2008 Mar-Apr;25(2):197-208. doi: 10.1017/S095252380808053X.
115. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
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