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Gene: Drd5 (dopamine receptor D5) Rattus norvegicus

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Symbol:

Drd5

Name:

dopamine receptor D5

RGD ID:

2523

Description:

Enables G-protein alpha-subunit binding activity and dopamine neurotransmitter receptor activity. Involved in several processes, including adenylate cyclase-activating dopamine receptor signaling pathway; negative regulation of protein kinase activity; and visual learning. Acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway. Located in several cellular components, including brush border membrane; dendritic spine; and neuronal cell body. Is active in glutamatergic synapse and postsynaptic density membrane. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder and blepharospasm. Orthologous to human DRD5 (dopamine receptor D5); PARTICIPATES IN dopamine signaling pathway; dopamine signaling pathway via D1 family of receptors; G protein mediated signaling pathway via Galphaq family; INTERACTS WITH 2,2',4,4',5,5'-hexachlorobiphenyl; 2,6-dinitrotoluene; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

d(1B) dopamine receptor; d(5) dopamine receptor; D1B; dopamine D5 receptor; dopamine receptor 5

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	DRD5 (dopamine receptor D5)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Drd5 (dopamine receptor D5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Drd5 (dopamine receptor D5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	DRD5 (dopamine receptor D5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	DRD5 (dopamine receptor D5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Drd5 (dopamine receptor D5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	DRD5 (dopamine receptor D5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	DRD5 (dopamine receptor D5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Drd5 (dopamine receptor D5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	QSOX1 (quiescin sulfhydryl oxidase 1)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Drd5 (dopamine receptor D5)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	DRD5 (dopamine receptor D5)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	dop-1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Dop1R1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	drd5	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	76,700,244 - 76,703,344 (-)	NCBI		GRCr8
mRatBN7.2	14	72,487,950 - 72,491,050 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	72,489,347 - 72,490,774 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	76,931,000 - 76,932,427 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	78,171,890 - 78,173,317 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	74,611,945 - 74,613,372 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	77,220,579 - 77,222,006 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	77,220,579 - 77,222,006 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	77,202,167 - 77,203,594 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	77,768,060 - 77,769,487 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	77,770,450 - 77,771,878 (-)	NCBI
Celera	14	71,440,495 - 71,441,922 (-)	NCBI		Celera
Cytogenetic Map	14	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Alzheimer's disease (ISO)

attention deficit hyperactivity disorder (ISO)

Benign Essential Blepharospasm (ISO)

bipolar disorder (ISO)

blepharospasm (ISO)

cervical dystonia (ISO)

depressive disorder (ISO)

Huntington's disease (ISO)

hypertension (ISO)

Parkinson's disease (ISO)

pervasive developmental disorder (ISO)

psychotic disorder (ISO)

schizophrenia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (EXP)

2,6-dinitrotoluene (EXP)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-sulfonyldiphenol (ISO)

5-fluorouracil (ISO)

5-formyltetrahydrofolic acid (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

ammonium chloride (EXP)

amphetamine (EXP)

antirheumatic drug (ISO)

Aroclor 1254 (EXP)

arsenite(3-) (ISO)

Azoxymethane (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP)

butanal (ISO)

C60 fullerene (EXP)

cadmium atom (ISO)

chlorpyrifos (ISO)

cobalt dichloride (ISO)

cocaine (EXP)

copper(II) sulfate (ISO)

Cuprizon (EXP)

decabromodiphenyl ether (EXP)

dextran sulfate (ISO)

dicoumarol (EXP)

diethylstilbestrol (EXP)

dopamine (EXP)

flavonoids (EXP)

gamma-aminobutyric acid (EXP)

hexane (EXP)

irinotecan (ISO)

leflunomide (ISO)

lipopolysaccharide (ISO)

maneb (ISO)

miconazole (EXP)

paraquat (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

potassium dichromate (ISO)

quercetin (EXP)

raloxifene (ISO)

resveratrol (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

sarin (ISO)

silicon dioxide (ISO)

tamoxifen (ISO)

theophylline (ISO)

titanium dioxide (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adenylate cyclase-activating adrenergic receptor signaling pathway (IBA)

adenylate cyclase-activating dopamine receptor signaling pathway (IEA,IMP,ISO)

adenylate cyclase-activating G protein-coupled receptor signaling pathway (IDA,ISO)

associative learning (IEA,ISO)

cellular response to catecholamine stimulus (ISO)

G protein-coupled dopamine receptor signaling pathway (IBA,IDA)

long-term synaptic depression (IEA,ISO)

mating behavior (ISO)

negative regulation of blood pressure (IEA,ISO)

negative regulation of cell migration (IMP)

negative regulation of NAD(P)H oxidase activity (ISO)

negative regulation of protein kinase activity (IMP)

norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure (IEA,ISO)

positive regulation of MAPK cascade (IBA)

reactive oxygen species metabolic process (IEA,ISO)

regulation of female receptivity (IEA,ISO)

regulation of locomotion (IEA)

regulation of postsynaptic membrane neurotransmitter receptor levels (EXP,IDA,IEP)

regulation of systemic arterial blood pressure by vasopressin (IEA,ISO)

response to amphetamine (IEA,ISO)

response to cocaine (IEA,ISO)

sensitization (IEA,ISO)

synaptic transmission, dopaminergic (IEA)

transmission of nerve impulse (IEA,ISO)

visual learning (IMP)

wound healing (IEA,ISO)

Cellular Component

axon (IDA)

brush border membrane (IDA,IEA,ISO)

ciliary membrane (IEA,ISO)

cilium (ISO)

dendrite (IDA)

dendritic spine (IDA)

glutamatergic synapse (EXP,IDA,IEA,IEP)

neuronal cell body (IDA)

non-motile cilium (IEA,ISO)

plasma membrane (IBA,ISO)

postsynaptic density membrane (IDA)

Molecular Function

dopamine binding (IEA,ISO)

dopamine neurotransmitter receptor activity (IDA,ISO)

dopamine neurotransmitter receptor activity, coupled via Gs (IBA,IEA,ISO)

G protein-coupled receptor activity (IBA,IEA)

G-protein alpha-subunit binding (IPI)

protein binding (IPI,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

calcium/calcium-mediated signaling pathway (IEA)

dopamine signaling pathway (ISO)

dopamine signaling pathway via D1 family of receptors (ISO)

G protein mediated signaling pathway via Galphaq family (ISO)

G protein mediated signaling pathway via Galphas family (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Striatal neurochemical changes in transgenic models of Huntington's disease.	Ariano MA, etal., J Neurosci Res. 2002 Jun 15;68(6):716-29.
2.	DAT1, DRD4, and DRD5 polymorphisms are not associated with ADHD in Dutch families.	Bakker SC, etal., Am J Med Genet B Neuropsychiatr Genet. 2005 Jan 5;132B(1):50-2.
3.	Increased expression of dopamine receptors on lymphocytes in Parkinson's disease.	Barbanti P, etal., Mov Disord. 1999 Sep;14(5):764-71.
4.	Attention-deficit hyperactivity disorder and the gene for the dopamine D5 receptor.	Barr CL, etal., Mol Psychiatry. 2000 Sep;5(5):548-51.
5.	The physiology, signaling, and pharmacology of dopamine receptors.	Beaulieu JM and Gainetdinov RR, Pharmacol Rev. 2011 Mar;63(1):182-217. doi: 10.1124/pr.110.002642. Epub 2011 Feb 8.
6.	Dopamine receptors - IUPHAR Review 13.	Beaulieu JM, etal., Br J Pharmacol. 2015 Jan;172(1):1-23.
7.	Dopamine D5 receptor localization on cholinergic neurons of the rat forebrain and diencephalon: a potential neuroanatomical substrate involved in mediating dopaminergic influences on acetylcholine release.	Berlanga ML, etal., J Comp Neurol. 2005 Nov 7;492(1):34-49.
8.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
10.	Mice lacking D5 dopamine receptors have increased sympathetic tone and are hypertensive.	Hollon TR, etal., J Neurosci. 2002 Dec 15;22(24):10801-10.
11.	Immunohistochemical localization of dopamine receptor subtypes (D1R-D5R) in Alzheimer's disease brain.	Kumar U and Patel SC, Brain Res. 2007 Feb 2;1131(1):187-96. Epub 2006 Dec 19.
12.	Transmission disequilibrium testing of dopamine-related candidate gene polymorphisms in ADHD: confirmation of association of ADHD with DRD4 and DRD5.	Kustanovich V, etal., Mol Psychiatry 2004 Jul;9(7):711-7.
13.	Dopamine D1/D5 receptors gate the acquisition of novel information through hippocampal long-term potentiation and long-term depression.	Lemon N and Manahan-Vaughan D, J Neurosci. 2006 Jul 19;26(29):7723-9.
14.	The usefulness of the spontaneously hypertensive rat to model attention-deficit/hyperactivity disorder (ADHD) may be explained by the differential expression of dopamine-related genes in the brain.	Li Q, etal., Neurochem Int. 2007 May;50(6):848-57. Epub 2007 Mar 1.
15.	Dopamine D5 receptors are localized at asymmetric synapses in the rat hippocampus.	Medin T, etal., Neuroscience. 2011 Sep 29;192:164-71. Epub 2011 Jun 25.
16.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
17.	A polymorphism in the dopamine receptor DRD5 is associated with blepharospasm.	Misbahuddin A, etal., Neurology 2002 Jan 8;58(1):124-6.
18.	Dopamine D1/D5 receptor activation fails to initiate an activity-independent late-phase LTP in rat hippocampus.	Mockett BG, etal., Brain Res. 2004 Sep 17;1021(1):92-100.
19.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
20.	Dopaminergic modulation of the persistence of one-trial hippocampus-dependent memory.	O'Carroll CM, etal., Learn Mem. 2006 Nov-Dec;13(6):760-9.
21.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
22.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
23.	Colocalization of dopamine receptor subtypes with dopamine and cAMP-regulated phosphoprotein (DARPP-32) in rat brain.	Rajput PS, etal., Neurosci Res. 2009 Sep;65(1):53-63. Epub 2009 May 22.
24.	GOA pipeline	RGD automated data pipeline
25.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
27.	Cocaine enhances NMDA receptor-mediated currents in ventral tegmental area cells via dopamine D5 receptor-dependent redistribution of NMDA receptors.	Schilström B, etal., J Neurosci. 2006 Aug 16;26(33):8549-58. doi: 10.1523/JNEUROSCI.5179-05.2006.
28.	Altered mRNA expression of monoaminergic candidate genes in the blood of children with attention deficit hyperactivity disorder and autism spectrum disorder.	Taurines R, etal., World J Biol Psychiatry. 2011 Sep;12 Suppl 1:104-8.
29.	Cloning, molecular characterization, and chromosomal assignment of a gene encoding a second D1 dopamine receptor subtype: differential expression pattern in rat brain compared with the D1A receptor.	Tiberi M, etal., Proc Natl Acad Sci U S A 1991 Sep 1;88(17):7491-5.
30.	The subcommissural organ expresses D2, D3, D4, and D5 dopamine receptors.	Tome M, etal., Cell Tissue Res. 2004 Jul;317(1):65-77. Epub 2004 Jun 9.
31.	Dopamine as a novel anti-migration factor of vascular smooth muscle cells through D1A and D1B receptors.	Yasunari K, etal., J Cardiovasc Pharmacol. 2003 Jan;41 Suppl 1:S33-8.
32.	Galpha12- and Galpha13-protein subunit linkage of D5 dopamine receptors in the nephron.	Zheng S, etal., Hypertension 2003 Mar;41(3):604-10.

Additional References at PubMed

PMID:1826762	PMID:9603210	PMID:10531415	PMID:11500503	PMID:11595429	PMID:11823893	PMID:12768268	PMID:12867509	PMID:13679419	PMID:15598876	PMID:15696326	PMID:16352863
PMID:16962565	PMID:17293055	PMID:18403039	PMID:19669160	PMID:19690230	PMID:19723560	PMID:20226768	PMID:20531939	PMID:20646048	PMID:21768371	PMID:22038910	PMID:22707255
PMID:23541742	PMID:23626827	PMID:23672849	PMID:23977170	PMID:25775606	PMID:27652590	PMID:28154160	PMID:28259782	PMID:28336436	PMID:29537707	PMID:34064454	PMID:34881789
PMID:35478421

Genomics

Comparative Map Data

Drd5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	76,700,244 - 76,703,344 (-)	NCBI		GRCr8
mRatBN7.2	14	72,487,950 - 72,491,050 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	72,489,347 - 72,490,774 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	76,931,000 - 76,932,427 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	78,171,890 - 78,173,317 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	74,611,945 - 74,613,372 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	77,220,579 - 77,222,006 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	77,220,579 - 77,222,006 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	77,202,167 - 77,203,594 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	77,768,060 - 77,769,487 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	77,770,450 - 77,771,878 (-)	NCBI
Celera	14	71,440,495 - 71,441,922 (-)	NCBI		Celera
Cytogenetic Map	14	q21	NCBI

DRD5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	9,781,634 - 9,784,009 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	9,781,634 - 9,784,009 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	9,783,258 - 9,785,633 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	9,392,701 - 9,394,731 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	4	9,459,871 - 9,461,901	NCBI
Celera	4	10,266,117 - 10,268,492 (+)	NCBI		Celera
Cytogenetic Map	4	p16.1	NCBI
HuRef	4	9,117,663 - 9,120,038 (+)	NCBI		HuRef
CHM1_1	4	9,781,174 - 9,783,549 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	4	9,781,407 - 9,783,782 (+)	NCBI		T2T-CHM13v2.0

Drd5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	38,476,742 - 38,479,868 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	38,476,710 - 38,479,861 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	38,319,509 - 38,322,523 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	38,319,367 - 38,322,518 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	38,710,748 - 38,713,549 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	38,607,758 - 38,610,559 (+)	NCBI		MGSCv36	mm8
Celera	5	35,773,146 - 35,775,947 (+)	NCBI		Celera
Cytogenetic Map	5	B3	NCBI
cM Map	5	20.4	NCBI

Drd5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955514	5,450,495 - 5,452,282 (+)	NCBI	ChiLan1.0	ChiLan1.0

DRD5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	10,026,932 - 10,030,293 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	10,235,569 - 10,237,977 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	4,189,536 - 4,193,144 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	9,508,711 - 9,511,072 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	9,509,094 - 9,510,527 (+)	Ensembl	panpan1.1		panPan2

DRD5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	3	69,621,187 - 69,623,522 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	3	69,621,734 - 69,623,893 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	3	72,173,244 - 72,175,212 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	3	70,378,089 - 70,380,057 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	3	70,378,633 - 70,380,057 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	3	69,652,224 - 69,654,192 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	3	69,817,637 - 69,819,605 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	3	70,198,942 - 70,200,910 (-)	NCBI		UU_Cfam_GSD_1.0

Drd5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405285	63,158,693 - 63,162,200 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936477	16,861,773 - 16,863,215 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936477	16,860,222 - 16,863,505 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DRD5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	6,180,221 - 6,181,636 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	6,180,221 - 6,182,575 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	5,694,230 - 5,696,186 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DRD5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	27	40,267,681 - 40,270,061 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	27	40,268,235 - 40,269,671 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666047	87,064,155 - 87,066,433 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Drd5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624755	21,358,586 - 21,361,410 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Drd5
13 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	72
Count of miRNA genes:	53
Interacting mature miRNAs:	63
Transcripts:	ENSRNOT00000007074
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2313089	Bss81	Bone structure and strength QTL 81	3.4	0.0001	body length (VT:0001256)	body length, nose to rump (CMO:0000079)	14	37669719	82669719	Rat
9590294	Uminl4	Urine mineral level QTL 4	5.66	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	14	55624247	100624247	Rat
2300197	Scl59	Serum cholesterol level QTL 59			blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	14	55147478	100147478	Rat
70214	Niddm28	Non-insulin dependent diabetes mellitus QTL 28	4.06		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	39998251	75582726	Rat
70153	Bp59	Blood pressure QTL 59	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	14	68757796	83368335	Rat
70187	Pancm5	Pancreatic morphology QTL 5	16.7		pancreas mass (VT:0010144)	pancreas weight to body weight ratio (CMO:0000630)	14	30320092	80829842	Rat
631523	Pia13	Pristane induced arthritis QTL 13	3.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	14	40793460	98037301	Rat
1582259	Gluco23	Glucose level QTL 23	3.1	0.0008	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	70053989	104886043	Rat
2313100	Bss82	Bone structure and strength QTL 82	3	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	14	37669719	82669719	Rat
634328	Hc5	Hypercalciuria QTL 5	2.3		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	14	58184885	103184885	Rat
2317879	Alcrsp27	Alcohol response QTL 27	3.3	0.63	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	14	56631369	101631369	Rat
1641900	Alcrsp11	Alcohol response QTL 11			alcohol metabolism trait (VT:0015089)	blood ethanol level (CMO:0000535)	14	70053989	104886043	Rat
631839	Niddm37	Non-insulin dependent diabetes mellitus QTL 37	3.37		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	11030622	95876975	Rat
9589034	Epfw11	Epididymal fat weight QTL 11	6	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	14	55624247	100624247	Rat
2313048	Bss84	Bone structure and strength QTL 84	3.1	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	14	37669719	82669719	Rat
1300136	Rf22	Renal function QTL 22	3.9		renal blood flow trait (VT:2000006)	absolute change in renal vascular resistance (CMO:0001900)	14	42262529	95023211	Rat
1549834	Scl45	Serum cholesterol level QTL 45	5.8		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	14	50023211	95023211	Rat
738037	Hcas6	Hepatocarcinoma susceptibility QTL 6	2.93		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)	14	39057237	83368335	Rat
2313084	Bss83	Bone structure and strength QTL 83	2.9	0.0001	tibia size trait (VT:0100001)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	14	37669719	82669719	Rat

Markers in Region

D14Mgh8

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	72,489,207 - 72,489,324 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	77,220,440 - 77,220,556	NCBI	Rnor6.0
Rnor_5.0	14	77,202,028 - 77,202,144	UniSTS	Rnor5.0
RGSC_v3.4	14	77,767,921 - 77,768,037	UniSTS	RGSC3.4
RGSC_v3.4	14	77,767,919 - 77,768,037	RGD	RGSC3.4
RGSC_v3.1	14	77,770,310 - 77,770,428	RGD
Celera	14	71,440,356 - 71,440,472	UniSTS
Cytogenetic Map	14	q21	UniSTS

D14Arb11

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	72,489,205 - 72,489,477 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	77,220,438 - 77,220,709	NCBI	Rnor6.0
Rnor_5.0	14	77,202,026 - 77,202,297	UniSTS	Rnor5.0
RGSC_v3.4	14	77,767,919 - 77,768,190	UniSTS	RGSC3.4
RGSC_v3.1	14	77,770,308 - 77,770,581	RGD
Celera	14	71,440,354 - 71,440,625	UniSTS
FHH x ACI Map	14	55.78	UniSTS
FHH x ACI Map	14	55.78	RGD
Cytogenetic Map	14	q21	UniSTS

D14Uia1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	72,489,204 - 72,489,304 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	77,220,437 - 77,220,536	NCBI	Rnor6.0
Rnor_5.0	14	77,202,025 - 77,202,124	UniSTS	Rnor5.0
RGSC_v3.4	14	77,767,918 - 77,768,017	UniSTS	RGSC3.4
RGSC_v3.4	14	77,767,917 - 77,768,017	RGD	RGSC3.4
RGSC_v3.1	14	77,770,308 - 77,770,408	RGD
Celera	14	71,440,353 - 71,440,452	UniSTS
Cytogenetic Map	14	q21	UniSTS

D14Mco3

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_5.0	14	77,202,026 - 77,202,220	UniSTS	Rnor5.0
Celera	14	71,440,354 - 71,440,548	UniSTS
Cytogenetic Map	14	q21	UniSTS

D14Mco14

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	72,489,205 - 72,489,400 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	77,220,438 - 77,220,632	NCBI	Rnor6.0
Rnor_5.0	14	77,202,026 - 77,202,220	UniSTS	Rnor5.0
RGSC_v3.4	14	77,767,919 - 77,768,113	UniSTS	RGSC3.4
Celera	14	71,440,354 - 71,440,548	UniSTS
Cytogenetic Map	14	q21	UniSTS

D14Wox23

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	72,489,208 - 72,489,385 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	77,220,441 - 77,220,617	NCBI	Rnor6.0
Rnor_5.0	14	77,202,029 - 77,202,205	UniSTS	Rnor5.0
RGSC_v3.4	14	77,767,922 - 77,768,098	UniSTS	RGSC3.4
Celera	14	71,440,357 - 71,440,533	UniSTS
Cytogenetic Map	14	q21	UniSTS

UniSTS:166211

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	72,489,425 - 72,489,600 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	77,220,658 - 77,220,832	NCBI	Rnor6.0
Rnor_5.0	14	77,202,246 - 77,202,420	UniSTS	Rnor5.0
RGSC_v3.4	14	77,768,139 - 77,768,313	UniSTS	RGSC3.4
Celera	14	71,440,574 - 71,440,748	UniSTS
Cytogenetic Map	14	q21	UniSTS

UniSTS:495985

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	72,489,987 - 72,490,057 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	77,221,220 - 77,221,289	NCBI	Rnor6.0
Rnor_5.0	14	77,202,808 - 77,202,877	UniSTS	Rnor5.0
RGSC_v3.4	14	77,768,701 - 77,768,770	UniSTS	RGSC3.4
Celera	14	71,441,136 - 71,441,205	UniSTS
Cytogenetic Map	14	q21	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	endoderm	exocrine system	hepatobiliary system	mesenchyme	nervous system	renal system	reproductive system
77	2	1	1	1	2	77	1	18

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_012768	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473963	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M69118	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000007074 ⟹ ENSRNOP00000007074

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	72,489,347 - 72,490,774 (-)	Ensembl
Rnor_6.0 Ensembl	14	77,220,579 - 77,222,006 (-)	Ensembl

RefSeq Acc Id:

NM_012768 ⟹ NP_036900

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	76,700,244 - 76,703,344 (-)	NCBI
mRatBN7.2	14	72,487,950 - 72,491,050 (-)	NCBI
Rnor_6.0	14	77,220,579 - 77,222,006 (-)	NCBI
Rnor_5.0	14	77,202,167 - 77,203,594 (-)	NCBI
RGSC_v3.4	14	77,768,060 - 77,769,487 (-)	RGD
Celera	14	71,440,495 - 71,441,922 (-)	RGD

Sequence:

show sequence

ATGCTGCCTCCTGGGCGCAACCGCACGGCTCAACCGGCAAGGCTGGGATTACAGAGGCAACTGG
CTCAGGTGGACGCCCCAGCGGGCTCTGCAACCCCACTGGGACCCGCGCAGGTGGTCACCGCAGG
CCTCCTGACTCTCCTAATCGTCTGGACCTTGCTCGGGAACGTGCTAGTGTGTGCTGCCATCGTC
CGCAGCCGCCATCTGCGCGCCAAGATGACCAACATCTTCATCGTATCCCTAGCTGTCTCAGACC
TCTTCGTGGCATTGCTGGTCATGCCCTGGAAGGCTGTGGCTGAGGTGGCTGGGTACTGGCCCTT
TGGGACATTCTGCGACATCTGGGTGGCCTTTGACATCATGTGCTCCACTGCCTCCATCCTGAAT
CTGTGTATCATCAGCGTGGACCGTTACTGGGCTATTTCCAGACCCTTCCGCTACGAGCGCAAGA
TGACCCAGCGAGTAGCCCTGGTCATGGTGGGCCTGGCCTGGACCTTGTCCATCCTCATCTCCTT
CATCCCGGTCCAACTCAATTGGCACAGAGACAAGGCAGGCTCCCAGGGCCAAGAGGGCCTGCTG
TCCAATGGGACACCCTGGGAGGAAGGCTGGGAGCTAGAAGGGAGGACGGAGAACTGTGACTCCA
GCCTGAACCGAACCTATGCCATCTCCTCGTCACTCATCAGCTTCTACATCCCGGTGGCCATCAT
GATCGTGACCTATACGCGTATCTACCGCATTGCGCAGGTGCAGATCCGGCGGATCTCCTCCCTA
GAGAGGGCAGCTGAGCATGCTCAGAGTTGCCGGAGTCGTGGAGCCTATGAACCTGACCCCAGCC
TGCGAGCGTCCATCAAGAAGGAGACCAAGGTCTTCAAAACCCTGTCAATGATCATGGGGGTCTT
CGTGTGTTGCTGGTTGCCTTTCTTCATCCTGAACTGTATGGTTCCTTTCTGCAGTAGTGGGGAT
GCCGAGGGCCCAAAGACTGGCTTCCCTTGTGTCAGCGAGACCACCTTCGACATATTCGTCTGGT
TTGGCTGGGCCAACTCCTCTCTCAATCCCATCATCTATGCCTTTAATGCAGACTTCCGGAAGGT
GTTTGCCCAGCTGCTGGGGTGCAGCCACTTCTGCTTCCGGACCCCAGTGCAGACGGTAAACATC
AGTAATGAGCTCATCTCCTACAACCAAGACACGGTCTTCCACAAGGAGATCGCTACTGCCTATG
TCCACATGATACCGAATGCAGTATCCTCCGGAGACAGGGAGGTGGGAGAGGAGGAGGAGGAGGG
GCCTTTCGATCACATGTCTCAAATCTCTCCAACGACGCCAGACGGTGACCTGGCTGCTGAGTCT
GTCTGGGAGCTTGACTGTGAGGAAGAGGTTTCCTTAGGCAAAATCTCACCTCTCACCCCCAATT
GTTTCGATAAAACTGCTTAG

hide sequence

Protein Sequences


Protein RefSeqs	NP_036900	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA41072	(Get FASTA)	NCBI Sequence Viewer
	EDL99998	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000007074.1
GenBank Protein	P25115	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_036900 ⟸ NM_012768

- UniProtKB:

G3V6N6 (UniProtKB/TrEMBL), A6IJT5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MLPPGRNRTAQPARLGLQRQLAQVDAPAGSATPLGPAQVVTAGLLTLLIVWTLLGNVLVCAAIV
RSRHLRAKMTNIFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGTFCDIWVAFDIMCSTASILN
LCIISVDRYWAISRPFRYERKMTQRVALVMVGLAWTLSILISFIPVQLNWHRDKAGSQGQEGLL
SNGTPWEEGWELEGRTENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSL
ERAAEHAQSCRSRGAYEPDPSLRASIKKETKVFKTLSMIMGVFVCCWLPFFILNCMVPFCSSGD
AEGPKTGFPCVSETTFDIFVWFGWANSSLNPIIYAFNADFRKVFAQLLGCSHFCFRTPVQTVNI
SNELISYNQDTVFHKEIATAYVHMIPNAVSSGDREVGEEEEEGPFDHMSQISPTTPDGDLAAES
VWELDCEEEVSLGKISPLTPNCFDKTA

hide sequence

Ensembl Acc Id:

ENSRNOP00000007074 ⟸ ENSRNOT00000007074

Protein Domains

G-protein coupled receptors family 1 profile

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P25115-F1-model_v2	AlphaFold	P25115	1-475	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2523	AgrOrtholog
BioCyc Gene	G2FUF-15387	BioCyc
Ensembl Genes	ENSRNOG00000005338	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000007074.3	UniProtKB/TrEMBL
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Dopamine_D5_rcpt	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Dopamine_rcpt	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCR_Rhodpsn	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCR_Rhodpsn_7TM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:25195	UniProtKB/Swiss-Prot
NCBI Gene	25195	ENTREZGENE
PANTHER	ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	D(1B) DOPAMINE RECEPTOR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	7tm_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB	DRD5	RGD
PhenoGen	Drd5	PhenoGen
PRINTS	DOPAMINED1BR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	DOPAMINER	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCRRHODOPSN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F1_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F1_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000005338	RatGTEx
SMART	7TM_GPCR_Srsx	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A6IJT5	ENTREZGENE, UniProtKB/TrEMBL
	DRD5_RAT	UniProtKB/Swiss-Prot
	G3V6N6	ENTREZGENE, UniProtKB/TrEMBL
	P25115	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2006-03-30	Drd5	dopamine receptor D5		dopamine receptor 5	Name updated	1299863	APPROVED
2002-06-10	Drd5	Dopamine receptor D5			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	present in hippocampus, mammillary nuclei, and anterior pretectal nuclei	728422
gene_protein	475 amino acids; 52.8 kDa	728422

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)