Dlg1 (discs large MAGUK scaffold protein 1) - Rat Genome Database

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Gene: Dlg1 (discs large MAGUK scaffold protein 1) Rattus norvegicus
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Symbol: Dlg1
Name: discs large MAGUK scaffold protein 1
RGD ID: 2505
Description: Enables several functions, including PDZ domain binding activity; ionotropic glutamate receptor binding activity; and kinesin binding activity. Involved in several processes, including cellular response to brain-derived neurotrophic factor stimulus; neurotransmitter receptor localization to postsynaptic specialization membrane; and positive regulation of potassium ion transport. Located in several cellular components, including basolateral plasma membrane; lateral plasma membrane; and paranode region of axon. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Biomarker of Parkinson's disease. Human ortholog(s) of this gene implicated in invasive ductal carcinoma. Orthologous to human DLG1 (discs large MAGUK scaffold protein 1); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH 17beta-estradiol; 6-propyl-2-thiouracil; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: discs large homolog 1; discs large homolog 1, scribble cell polarity complex component; discs, large homolog 1; disks large homolog 1; Dlgh1; Drosophila discs-large tumor suppressor homologue (synapse associated protein); SAP-97; SAP97; synapse-associated protein 97
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Dlg1Tn(sb-T2/Bart3)2.133Mcwi
Genetic Models: F344-Dlg1Tn(sb-T2/Bart3)2.133Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81182,416,853 - 82,607,797 (-)NCBIGRCr8
mRatBN7.21168,911,883 - 69,103,230 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1168,911,883 - 69,102,689 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_WKY_Bbb_1.0PNS010000869.13,863 - 29,596 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
UTH_Rnor_WKY_Bbb_1.0PNS010000782.1738 - 5,614 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01172,164,566 - 72,378,895 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1172,163,749 - 72,378,895 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01175,389,409 - 75,454,358 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01175,239,783 - 75,349,409 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41170,735,283 - 70,930,374 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11170,792,871 - 70,987,963 (-)NCBI
Celera1168,335,260 - 68,524,109 (-)NCBICelera
Cytogenetic Map11q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,6-dimethoxyphenol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
Butylparaben  (EXP)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcidiol  (EXP)
carbon nanotube  (ISO)
chlorpyrifos  (EXP)
cobalt dichloride  (ISO)
coumarin  (ISO)
cyclosporin A  (ISO)
DDE  (EXP)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dioxygen  (ISO)
dizocilpine maleate  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
enzacamene  (EXP)
epoxiconazole  (EXP)
ethanol  (ISO)
finasteride  (EXP)
fipronil  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
furfural  (ISO)
geldanamycin  (ISO)
gentamycin  (EXP)
hemin  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
inulin  (ISO)
irinotecan  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
linuron  (EXP)
methapyrilene  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
minocycline  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
nicotinamide  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
oxidopamine  (EXP)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pexidartinib  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (ISO)
poly(I:C)  (EXP)
potassium chromate  (ISO)
prochloraz  (EXP)
procymidone  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sulforaphane  (EXP)
sulindac  (EXP)
teprenone  (ISO)
tert-butyl hydroperoxide  (ISO)
theophylline  (ISO)
thimerosal  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin filament organization  (IEA,ISO,ISS)
actin filament polymerization  (IEA,ISO)
activation of protein kinase activity  (ISO)
amyloid precursor protein metabolic process  (IEA,ISO)
astral microtubule organization  (IEA,ISO)
bicellular tight junction assembly  (IEA,ISO)
branching involved in ureteric bud morphogenesis  (IEA,ISO)
cell adhesion  (IEP)
cell population proliferation  (IEA,ISO)
cell-cell adhesion  (IBA,IEA,ISO,ISS)
cellular response to brain-derived neurotrophic factor stimulus  (IDA)
cerebral cortex development  (IEP)
chemical synaptic transmission  (IBA,IEA)
cortical actin cytoskeleton organization  (IEA,ISO,ISS)
cortical microtubule organization  (IEA,ISO)
embryonic skeletal system morphogenesis  (IEA,ISO)
endothelial cell proliferation  (IEA,ISO,ISS)
epithelial structure maintenance  (ISO,ISS)
establishment of centrosome localization  (IEA,ISO)
establishment or maintenance of epithelial cell apical/basal polarity  (IBA)
hard palate development  (IEA,ISO)
immunological synapse formation  (IEA,ISO)
lens development in camera-type eye  (IEA,ISO)
maintenance of postsynaptic density structure  (IEA)
membrane raft organization  (IEA,ISO)
membrane repolarization during ventricular cardiac muscle cell action potential  (IEA,ISO)
negative regulation of epithelial cell proliferation  (IEA,ISO)
negative regulation of ERK1 and ERK2 cascade  (IEA,ISO)
negative regulation of G1/S transition of mitotic cell cycle  (IEA,ISO,ISS)
negative regulation of p38MAPK cascade  (IEA,ISO)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
negative regulation of T cell proliferation  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
nervous system development  (IBA)
neurotransmitter receptor localization to postsynaptic specialization membrane  (IDA,IEA,IMP,ISO)
peristalsis  (IEA,ISO)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
positive regulation of actin filament polymerization  (IEA,ISO)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of gene expression  (IDA)
positive regulation of potassium ion transport  (IEA,IMP,ISO)
positive regulation of protein localization to plasma membrane  (IEA,ISO)
protein localization  (IEA,ISO)
protein localization to plasma membrane  (IEA,ISO)
protein localization to synapse  (IBA)
protein-containing complex localization  (IEA,ISO)
receptor clustering  (IBA)
receptor localization to synapse  (IBA)
regulation of cell shape  (IEA,ISO)
regulation of membrane potential  (IEA,ISO)
regulation of myelination  (IEA,ISO)
regulation of non-canonical NF-kappaB signal transduction  (ISO)
regulation of postsynaptic membrane neurotransmitter receptor levels  (IBA)
regulation of potassium ion export across plasma membrane  (IEA,ISO)
regulation of potassium ion import  (IEA,ISO)
regulation of protein localization  (IMP)
regulation of protein localization to synapse  (IEA,ISO)
regulation of ventricular cardiac muscle cell action potential  (IEA,ISO)
reproductive structure development  (IEA,ISO)
smooth muscle tissue development  (IEA,ISO)
T cell activation  (IEA,ISO)
T cell proliferation  (IEA,ISO)
tissue morphogenesis  (IEA,ISO)
ureteric bud development  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway   (ISO)
calcium/calmodulin dependent kinase 2 signaling pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
E-cadherin signaling pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
T cell receptor signaling pathway  (IEA)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Corticotropin-Releasing Hormone Receptor Type 1 (CRHR1) Clustering with MAGUKs Is Mediated via Its C-Terminal PDZ Binding Motif. Bender J, etal., PLoS One. 2015 Sep 9;10(9):e0136768. doi: 10.1371/journal.pone.0136768. eCollection 2015.
2. Dlg1, Sec8, and Mtmr2 regulate membrane homeostasis in Schwann cell myelination. Bolis A, etal., J Neurosci. 2009 Jul 8;29(27):8858-70. doi: 10.1523/JNEUROSCI.1423-09.2009.
3. Polarity and developmental regulation of two PDZ proteins in the retinal pigment epithelium. Bonilha VL and Rodriguez-Boulan E, Invest Ophthalmol Vis Sci. 2001 Dec;42(13):3274-82.
4. Localization of postsynaptic density-93 to dendritic microtubules and interaction with microtubule-associated protein 1A. Brenman JE, etal., J Neurosci. 1998 Nov 1;18(21):8805-13.
5. Selective Binding of Synapse-associated Protein 97 to GluR-A alpha -Amino-5-hydroxy-3-methyl-4-isoxazole Propionate Receptor Subunit Is Determined by a Novel Sequence Motif. Cai C, etal., J Biol Chem 2002 Aug 30;277(35):31484-90.
6. Interaction between SAP97 and PSD-95, two Maguk proteins involved in synaptic trafficking of AMPA receptors. Cai C, etal., J Biol Chem. 2006 Feb 17;281(7):4267-73. Epub 2005 Dec 6.
7. CaMKII regulation in information processing and storage. Coultrap SJ and Bayer KU, Trends Neurosci. 2012 Oct;35(10):607-18. doi: 10.1016/j.tins.2012.05.003. Epub 2012 Jun 19.
8. Distribution of the scaffolding proteins PSD-95, PSD-93, and SAP97 in isolated PSDs. DeGiorgis JA, etal., Brain Cell Biol. 2006 Dec;35(4-6):239-50. Epub 2008 Apr 5.
9. Plasma membrane Ca2+-atpase isoforms 2b and 4b interact promiscuously and selectively with members of the membrane-associated guanylate kinase family of PDZ (PSD95/Dlg/ZO-1) domain-containing proteins. DeMarco SJ and Strehler EE, J Biol Chem. 2001 Jun 15;276(24):21594-600. Epub 2001 Mar 26.
10. Kv4 potassium channels form a tripartite complex with the anchoring protein SAP97 and CaMKII in cardiac myocytes. El-Haou S, etal., Circ Res. 2009 Mar 27;104(6):758-69. Epub 2009 Feb 12.
11. Oncogenic function for the Dlg1 mammalian homolog of the Drosophila discs-large tumor suppressor. Frese KK, etal., EMBO J. 2006 Mar 22;25(6):1406-17. Epub 2006 Mar 2.
12. Somatic mutations and altered expression of the candidate tumor suppressors CSNK1 epsilon, DLG1, and EDD/hHYD in mammary ductal carcinoma. Fuja TJ, etal., Cancer Res. 2004 Feb 1;64(3):942-51.
13. CaMKII-dependent phosphorylation regulates SAP97/NR2A interaction. Gardoni F, etal., J Biol Chem 2003 Nov 7;278(45):44745-52. Epub 2003 Aug 21.
14. SAP97 directs the localization of Kv4.2 to spines in hippocampal neurons: regulation by CaMKII. Gardoni F, etal., J Biol Chem. 2007 Sep 28;282(39):28691-9. Epub 2007 Jul 16.
15. A critical interaction between NR2B and MAGUK in L-DOPA induced dyskinesia. Gardoni F, etal., J Neurosci. 2006 Mar 15;26(11):2914-22.
16. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
17. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
18. Acute BDNF treatment upregulates GluR1-SAP97 and GluR2-GRIP1 interactions: implications for sustained AMPA receptor expression. Jourdi H and Kabbaj M, PLoS One. 2013;8(2):e57124. doi: 10.1371/journal.pone.0057124. Epub 2013 Feb 27.
19. Brain-derived neurotrophic factor signal enhances and maintains the expression of AMPA receptor-associated PDZ proteins in developing cortical neurons. Jourdi H, etal., Dev Biol. 2003 Nov 15;263(2):216-30. doi: 10.1016/j.ydbio.2003.07.008.
20. Synaptic removal of diacylglycerol by DGKzeta and PSD-95 regulates dendritic spine maintenance. Kim K, etal., EMBO J. 2009 Apr 22;28(8):1170-9. doi: 10.1038/emboj.2009.44. Epub 2009 Feb 19.
21. Binding of human virus oncoproteins to hDlg/SAP97, a mammalian homolog of the Drosophila discs large tumor suppressor protein. Lee SS, etal., Proc Natl Acad Sci U S A. 1997 Jun 24;94(13):6670-5.
22. A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels. Leonoudakis D, etal., J Biol Chem 2004 Apr 30;279(18):19051-63. Epub 2004 Feb 11.
23. Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins. Leonoudakis D, etal., J Biol Chem. 2004 May 21;279(21):22331-46. Epub 2004 Mar 15.
24. Inward rectifier potassium channel Kir2.2 is associated with synapse-associated protein SAP97. Leonoudakis D, etal., J Cell Sci. 2001 Mar;114(Pt 5):987-98.
25. Regulation of the discs large tumor suppressor by a phosphorylation-dependent interaction with the beta-TrCP ubiquitin ligase receptor. Mantovani F and Banks L, J Biol Chem. 2003 Oct 24;278(43):42477-86. Epub 2003 Aug 5.
26. Synapse-associated protein-97 mediates alpha-secretase ADAM10 trafficking and promotes its activity. Marcello E, etal., J Neurosci. 2007 Feb 14;27(7):1682-91.
27. Neuronal proteins involved in synaptic targeting of AMPA receptors in rat hippocampus by antidepressant drugs. Martinez-Turrillas R, etal., Biochem Biophys Res Commun. 2007 Feb 16;353(3):750-5. Epub 2006 Dec 19.
28. Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein. Matsumine A, etal., Science. 1996 May 17;272(5264):1020-3. doi: 10.1126/science.272.5264.1020.
29. SAP97 promotes the stability of Nax channels at the plasma membrane. Matsumoto M, etal., FEBS Lett. 2012 Nov 2;586(21):3805-12. doi: 10.1016/j.febslet.2012.09.018. Epub 2012 Sep 25.
30. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
31. Dynamic reciprocity of sodium and potassium channel expression in a macromolecular complex controls cardiac excitability and arrhythmia. Milstein ML, etal., Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):E2134-43. doi: 10.1073/pnas.1109370109. Epub 2012 Apr 16.
32. Association of the kinesin superfamily motor protein KIF1Balpha with postsynaptic density-95 (PSD-95), synapse-associated protein-97, and synaptic scaffolding molecule PSD-95/discs large/zona occludens-1 proteins. Mok H, etal., J Neurosci. 2002 Jul 1;22(13):5253-8.
33. Molecular characterization and spatial distribution of SAP97, a novel presynaptic protein homologous to SAP90 and the Drosophila discs-large tumor suppressor protein. Muller BM, etal., J Neurosci 1995 Mar;15(3 Pt 2):2354-66.
34. Subcellular redistribution of the synapse-associated proteins PSD-95 and SAP97 in animal models of Parkinson's disease and L-DOPA-induced dyskinesia. Nash JE, etal., FASEB J. 2005 Apr;19(6):583-5. Epub 2005 Feb 9.
35. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
36. Kif13b Regulates PNS and CNS Myelination through the Dlg1 Scaffold. Noseda R, etal., PLoS Biol. 2016 Apr 12;14(4):e1002440. doi: 10.1371/journal.pbio.1002440. eCollection 2016 Apr.
37. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
38. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
39. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
40. GOA pipeline RGD automated data pipeline
41. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
42. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
43. Synapse-associated protein-97 isoform-specific regulation of surface AMPA receptors and synaptic function in cultured neurons. Rumbaugh G, etal., J Neurosci. 2003 Jun 1;23(11):4567-76.
44. Pursuit auditory tracking of dichotically presented tonal amplitudes. Sussman HM, etal., J Speech Hear Res. 1975 Mar;18(1):74-81.
45. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
46. Interaction of LDL receptor-related protein 4 (LRP4) with postsynaptic scaffold proteins via its C-terminal PDZ domain-binding motif, and its regulation by Ca/calmodulin-dependent protein kinase II. Tian QB, etal., Eur J Neurosci. 2006 Jun;23(11):2864-76.
47. Binding of PTEN to specific PDZ domains contributes to PTEN protein stability and phosphorylation by microtubule-associated serine/threonine kinases. Valiente M, etal., J Biol Chem. 2005 Aug 12;280(32):28936-43. Epub 2005 Jun 10.
48. SAP97 concentrates at the postsynaptic density in cerebral cortex. Valtschanoff JG, etal., Eur J Neurosci. 2000 Oct;12(10):3605-14.
49. Peptide binding and NMR analysis of the interaction between SAP97 PDZ2 and GluR-A: potential involvement of a disulfide bond. von Ossowski L, etal., Biochemistry. 2006 May 2;45(17):5567-75.
50. A novel family of adhesion-like molecules that interacts with the NMDA receptor. Wang CY, etal., J Neurosci. 2006 Feb 22;26(8):2174-83.
51. DGKiota regulates presynaptic release during mGluR-dependent LTD. Yang J, etal., EMBO J. 2011 Jan 5;30(1):165-80. doi: 10.1038/emboj.2010.286. Epub 2010 Nov 30.
52. Guanylate kinase domains of the MAGUK family scaffold proteins as specific phospho-protein-binding modules. Zhu J, etal., EMBO J. 2011 Nov 25;30(24):4986-97. doi: 10.1038/emboj.2011.428.
Additional References at PubMed
PMID:8601796   PMID:8922391   PMID:9341123   PMID:9674605   PMID:10646847   PMID:10656683   PMID:10779557   PMID:10939335   PMID:11238884   PMID:12050163   PMID:12351654   PMID:12857860  
PMID:12970345   PMID:14596909   PMID:14645510   PMID:14681019   PMID:14699157   PMID:15263016   PMID:15277200   PMID:15673434   PMID:15699074   PMID:15729360   PMID:16105026   PMID:16495462  
PMID:16621792   PMID:16815335   PMID:16882004   PMID:17172448   PMID:17187070   PMID:17237226   PMID:17332497   PMID:17335044   PMID:17435047   PMID:17724087   PMID:18004877   PMID:19357261  
PMID:19620977   PMID:19632332   PMID:19633205   PMID:19836928   PMID:19858198   PMID:20133708   PMID:20237282   PMID:20448149   PMID:20458337   PMID:20530486   PMID:20551903   PMID:20625331  
PMID:20865734   PMID:21164104   PMID:21615688   PMID:21768261   PMID:21920314   PMID:22242544   PMID:22718765   PMID:22871113   PMID:23038739   PMID:23576434   PMID:23676497   PMID:23696820  
PMID:24191021   PMID:25447080   PMID:25468996   PMID:25701814   PMID:26149358   PMID:29476059   PMID:30067285   PMID:35039052   PMID:35145085   PMID:38461868  


Genomics

Comparative Map Data
Dlg1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81182,416,853 - 82,607,797 (-)NCBIGRCr8
mRatBN7.21168,911,883 - 69,103,230 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1168,911,883 - 69,102,689 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_WKY_Bbb_1.0PNS010000869.13,863 - 29,596 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
UTH_Rnor_WKY_Bbb_1.0PNS010000782.1738 - 5,614 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01172,164,566 - 72,378,895 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1172,163,749 - 72,378,895 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01175,389,409 - 75,454,358 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01175,239,783 - 75,349,409 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41170,735,283 - 70,930,374 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11170,792,871 - 70,987,963 (-)NCBI
Celera1168,335,260 - 68,524,109 (-)NCBICelera
Cytogenetic Map11q22NCBI
DLG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383197,042,560 - 197,299,321 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3197,042,560 - 197,299,330 (-)EnsemblGRCh38hg38GRCh38
GRCh373196,769,431 - 197,026,192 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363198,253,828 - 198,509,844 (-)NCBINCBI36Build 36hg18NCBI36
Build 343198,259,732 - 198,513,757NCBI
Celera3195,354,807 - 195,610,760 (-)NCBICelera
Cytogenetic Map3q29NCBI
HuRef3194,068,872 - 194,324,699 (-)NCBIHuRef
CHM1_13196,740,135 - 196,996,273 (-)NCBICHM1_1
T2T-CHM13v2.03199,768,533 - 200,020,586 (-)NCBIT2T-CHM13v2.0
Dlg1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391631,482,261 - 31,692,174 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1631,482,261 - 31,693,947 (+)EnsemblGRCm39 Ensembl
GRCm381631,663,443 - 31,873,356 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1631,663,443 - 31,875,129 (+)EnsemblGRCm38mm10GRCm38
MGSCv371631,664,125 - 31,873,432 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361631,583,786 - 31,793,093 (+)NCBIMGSCv36mm8
Celera1632,162,337 - 32,367,214 (+)NCBICelera
Cytogenetic Map16B2NCBI
cM Map1622.4NCBI
Dlg1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542013,068,289 - 13,273,805 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542013,068,289 - 13,273,805 (-)NCBIChiLan1.0ChiLan1.0
DLG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22194,912,403 - 195,173,774 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13194,917,123 - 195,178,690 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03194,386,263 - 194,648,015 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13204,319,410 - 204,586,232 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3204,323,724 - 204,584,987 (-)Ensemblpanpan1.1panPan2
DLG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13330,016,323 - 30,253,180 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3330,016,600 - 30,253,547 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3330,039,726 - 30,276,522 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03330,264,744 - 30,502,044 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3330,264,748 - 30,501,362 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13330,059,072 - 30,295,858 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03330,096,091 - 30,333,239 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03330,717,286 - 30,954,124 (-)NCBIUU_Cfam_GSD_1.0
Dlg1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602143,094,725 - 143,350,067 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936833551,799 - 844,121 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936833551,989 - 843,064 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DLG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13132,820,870 - 133,086,841 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113132,819,931 - 133,084,880 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213142,336,324 - 142,629,113 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DLG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11589,937,900 - 90,214,976 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1590,055,964 - 90,215,652 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604163,711,831 - 63,988,641 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dlg1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473062,002,280 - 62,223,319 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473062,001,547 - 62,223,098 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dlg1
1029 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:39
Count of miRNA genes:38
Interacting mature miRNAs:39
Transcripts:ENSRNOT00000058885
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)114545932375190161Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)111945620576331918Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116611332182169223Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)115980279482566545Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat

Markers in Region
AW530915  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21089,702,043 - 89,702,208 (+)MAPPERmRatBN7.2
mRatBN7.21168,946,213 - 68,946,378 (-)MAPPERmRatBN7.2
mRatBN7.21089,702,043 - 89,702,208 (-)MAPPERmRatBN7.2
mRatBN7.21168,946,213 - 68,946,378 (+)MAPPERmRatBN7.2
Rnor_6.01092,916,666 - 92,916,830NCBIRnor6.0
Rnor_6.01172,208,294 - 72,208,458NCBIRnor6.0
Rnor_5.01175,283,122 - 75,283,286UniSTSRnor5.0
Rnor_5.01092,675,244 - 92,675,408UniSTSRnor5.0
RGSC_v3.41094,120,433 - 94,120,597UniSTSRGSC3.4
RGSC_v3.41170,769,193 - 70,769,357UniSTSRGSC3.4
Celera1168,368,229 - 68,368,393UniSTS
Celera1088,387,767 - 88,387,931UniSTS
Cytogenetic Map11q22UniSTS
BE109290  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21168,953,570 - 68,953,725 (+)MAPPERmRatBN7.2
Rnor_6.01172,215,651 - 72,215,805NCBIRnor6.0
Rnor_5.01175,290,479 - 75,290,633UniSTSRnor5.0
RGSC_v3.41170,776,550 - 70,776,704UniSTSRGSC3.4
Celera1168,375,585 - 68,375,739UniSTS
RH 3.4 Map11405.0UniSTS
Cytogenetic Map11q22UniSTS
RH138276  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21168,961,352 - 68,961,486 (+)MAPPERmRatBN7.2
Rnor_6.01172,223,456 - 72,223,589NCBIRnor6.0
Rnor_5.01175,298,284 - 75,298,417UniSTSRnor5.0
RGSC_v3.41170,784,355 - 70,784,488UniSTSRGSC3.4
Celera1168,382,733 - 68,382,866UniSTS
RH 3.4 Map11402.7UniSTS
Cytogenetic Map11q22UniSTS
AU049047  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21168,959,734 - 68,959,945 (+)MAPPERmRatBN7.2
Rnor_6.01172,221,840 - 72,222,048NCBIRnor6.0
Rnor_5.01175,296,668 - 75,296,876UniSTSRnor5.0
RGSC_v3.41170,782,739 - 70,782,947UniSTSRGSC3.4
Celera1168,381,104 - 68,381,325UniSTS
Cytogenetic Map11q22UniSTS


Genetic Models
This gene Dlg1 is modified in the following models/strains:
F344-Dlg1Tn(sb-T2/Bart3)2.133Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001393734 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_012788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270302 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270303 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005490974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005490975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005490976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005490977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U14950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000058885   ⟹   ENSRNOP00000055672
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1168,913,345 - 69,102,689 (-)Ensembl
Rnor_6.0 Ensembl1172,164,566 - 72,378,895 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000078737   ⟹   ENSRNOP00000071898
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1168,911,883 - 69,102,545 (-)Ensembl
Rnor_6.0 Ensembl1172,163,749 - 72,378,718 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102386   ⟹   ENSRNOP00000088710
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1168,911,883 - 69,102,545 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108927   ⟹   ENSRNOP00000097997
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1168,913,345 - 69,029,008 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109975   ⟹   ENSRNOP00000085582
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1168,911,883 - 69,030,997 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000113230   ⟹   ENSRNOP00000081862
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1168,913,345 - 69,030,997 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117728   ⟹   ENSRNOP00000091905
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1168,913,345 - 69,102,689 (-)Ensembl
RefSeq Acc Id: NM_001393734   ⟹   NP_001380663
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81182,416,853 - 82,607,797 (-)NCBI
mRatBN7.21168,911,883 - 69,102,803 (-)NCBI
RefSeq Acc Id: NM_012788   ⟹   NP_036920
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81182,416,853 - 82,607,797 (-)NCBI
mRatBN7.21168,911,883 - 69,102,803 (-)NCBI
Rnor_6.01172,164,566 - 72,378,895 (-)NCBI
Rnor_5.01175,239,783 - 75,349,409 (-)NCBI
Rnor_5.01175,389,409 - 75,454,358 (-)NCBI
RGSC_v3.41170,735,283 - 70,930,374 (-)RGD
Celera1168,335,260 - 68,524,109 (-)RGD
Sequence:
RefSeq Acc Id: XM_039088002   ⟹   XP_038943930
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81182,416,855 - 82,606,924 (-)NCBI
mRatBN7.21168,911,883 - 69,102,340 (-)NCBI
RefSeq Acc Id: XM_039088003   ⟹   XP_038943931
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81182,416,855 - 82,606,924 (-)NCBI
mRatBN7.21168,911,883 - 69,102,311 (-)NCBI
RefSeq Acc Id: XM_039088004   ⟹   XP_038943932
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81182,416,855 - 82,606,924 (-)NCBI
mRatBN7.21168,911,883 - 69,102,311 (-)NCBI
RefSeq Acc Id: XM_039088005   ⟹   XP_038943933
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81182,416,855 - 82,606,924 (-)NCBI
mRatBN7.21168,911,883 - 69,102,311 (-)NCBI
RefSeq Acc Id: XM_039088006   ⟹   XP_038943934
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81182,416,855 - 82,606,924 (-)NCBI
mRatBN7.21168,911,883 - 69,102,342 (-)NCBI
RefSeq Acc Id: XM_039088007   ⟹   XP_038943935
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81182,416,855 - 82,606,924 (-)NCBI
mRatBN7.21168,911,883 - 69,102,311 (-)NCBI
RefSeq Acc Id: XM_039088008   ⟹   XP_038943936
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81182,416,855 - 82,606,924 (-)NCBI
mRatBN7.21168,911,883 - 69,102,311 (-)NCBI
RefSeq Acc Id: XM_039088013   ⟹   XP_038943941
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81182,416,855 - 82,606,924 (-)NCBI
mRatBN7.21168,911,883 - 69,102,311 (-)NCBI
RefSeq Acc Id: XM_039088014   ⟹   XP_038943942
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81182,416,855 - 82,606,924 (-)NCBI
mRatBN7.21168,911,883 - 69,102,311 (-)NCBI
RefSeq Acc Id: XM_039088015   ⟹   XP_038943943
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81182,416,855 - 82,606,924 (-)NCBI
mRatBN7.21168,911,883 - 69,102,311 (-)NCBI
RefSeq Acc Id: XM_039088016   ⟹   XP_038943944
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81182,416,855 - 82,606,924 (-)NCBI
mRatBN7.21168,911,883 - 69,102,311 (-)NCBI
RefSeq Acc Id: XM_039088017   ⟹   XP_038943945
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81182,416,855 - 82,607,516 (-)NCBI
mRatBN7.21168,911,883 - 69,102,518 (-)NCBI
RefSeq Acc Id: XM_039088019   ⟹   XP_038943947
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81182,416,855 - 82,538,925 (-)NCBI
mRatBN7.21168,911,883 - 69,029,619 (-)NCBI
RefSeq Acc Id: XM_039088020   ⟹   XP_038943948
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81182,416,855 - 82,581,366 (-)NCBI
mRatBN7.21168,911,883 - 69,076,406 (-)NCBI
RefSeq Acc Id: XM_039088021   ⟹   XP_038943949
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81182,416,855 - 82,538,925 (-)NCBI
mRatBN7.21168,911,883 - 69,029,616 (-)NCBI
RefSeq Acc Id: XM_039088022   ⟹   XP_038943950
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81182,416,855 - 82,538,925 (-)NCBI
mRatBN7.21168,911,883 - 69,029,615 (-)NCBI
RefSeq Acc Id: XM_039088023   ⟹   XP_038943951
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81182,416,855 - 82,538,925 (-)NCBI
mRatBN7.21168,911,883 - 69,029,613 (-)NCBI
RefSeq Acc Id: XM_039088024   ⟹   XP_038943952
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81182,416,855 - 82,538,925 (-)NCBI
mRatBN7.21168,911,883 - 69,029,613 (-)NCBI
RefSeq Acc Id: XM_039088025   ⟹   XP_038943953
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81182,416,855 - 82,538,925 (-)NCBI
mRatBN7.21168,911,883 - 69,029,610 (-)NCBI
RefSeq Acc Id: XM_063270298   ⟹   XP_063126368
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81182,416,855 - 82,606,924 (-)NCBI
RefSeq Acc Id: XM_063270299   ⟹   XP_063126369
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81182,416,855 - 82,607,516 (-)NCBI
RefSeq Acc Id: XM_063270300   ⟹   XP_063126370
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81182,416,855 - 82,607,516 (-)NCBI
RefSeq Acc Id: XM_063270301   ⟹   XP_063126371
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81182,416,855 - 82,538,925 (-)NCBI
RefSeq Acc Id: XM_063270302   ⟹   XP_063126372
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81182,416,855 - 82,538,925 (-)NCBI
RefSeq Acc Id: XM_063270303   ⟹   XP_063126373
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81182,416,855 - 82,538,925 (-)NCBI
RefSeq Acc Id: XR_005490974
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81182,432,741 - 82,606,924 (-)NCBI
mRatBN7.21168,927,780 - 69,102,342 (-)NCBI
RefSeq Acc Id: XR_005490975
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81182,433,643 - 82,606,924 (-)NCBI
mRatBN7.21168,928,674 - 69,102,342 (-)NCBI
RefSeq Acc Id: XR_005490976
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81182,435,126 - 82,606,924 (-)NCBI
mRatBN7.21168,928,661 - 69,102,342 (-)NCBI
RefSeq Acc Id: XR_005490977
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81182,432,741 - 82,606,924 (-)NCBI
mRatBN7.21168,927,291 - 69,102,344 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001380663 (Get FASTA)   NCBI Sequence Viewer  
  NP_036920 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943930 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943931 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943932 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943933 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943934 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943935 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943936 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943941 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943942 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943943 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943944 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943945 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943947 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943948 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943949 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943950 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943951 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943952 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943953 (Get FASTA)   NCBI Sequence Viewer  
  XP_063126368 (Get FASTA)   NCBI Sequence Viewer  
  XP_063126369 (Get FASTA)   NCBI Sequence Viewer  
  XP_063126370 (Get FASTA)   NCBI Sequence Viewer  
  XP_063126371 (Get FASTA)   NCBI Sequence Viewer  
  XP_063126372 (Get FASTA)   NCBI Sequence Viewer  
  XP_063126373 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA79976 (Get FASTA)   NCBI Sequence Viewer  
  EDM11457 (Get FASTA)   NCBI Sequence Viewer  
  EDM11458 (Get FASTA)   NCBI Sequence Viewer  
  EDM11459 (Get FASTA)   NCBI Sequence Viewer  
  EDM11460 (Get FASTA)   NCBI Sequence Viewer  
  EDM11461 (Get FASTA)   NCBI Sequence Viewer  
  EDM11462 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000071898
  ENSRNOP00000081862
  ENSRNOP00000085582
  ENSRNOP00000088710
  ENSRNOP00000091905
  ENSRNOP00000097997
GenBank Protein Q62696 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036920   ⟸   NM_012788
- Peptide Label: isoform 1
- UniProtKB: Q62696 (UniProtKB/Swiss-Prot),   A6IRV7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000055672   ⟸   ENSRNOT00000058885
Ensembl Acc Id: ENSRNOP00000071898   ⟸   ENSRNOT00000078737
RefSeq Acc Id: XP_038943945   ⟸   XM_039088017
- Peptide Label: isoform X13
- UniProtKB: Q62696 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038943934   ⟸   XM_039088006
- Peptide Label: isoform X5
- UniProtKB: Q62696 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038943930   ⟸   XM_039088002
- Peptide Label: isoform X1
- UniProtKB: Q62696 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038943944   ⟸   XM_039088016
- Peptide Label: isoform X12
- UniProtKB: Q62696 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038943943   ⟸   XM_039088015
- Peptide Label: isoform X11
- UniProtKB: Q62696 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038943942   ⟸   XM_039088014
- Peptide Label: isoform X10
- UniProtKB: Q62696 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038943941   ⟸   XM_039088013
- Peptide Label: isoform X9
- UniProtKB: A6IRV5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038943936   ⟸   XM_039088008
- Peptide Label: isoform X7
- UniProtKB: Q62696 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038943935   ⟸   XM_039088007
- Peptide Label: isoform X6
- UniProtKB: Q62696 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038943933   ⟸   XM_039088005
- Peptide Label: isoform X4
- UniProtKB: Q62696 (UniProtKB/Swiss-Prot),   A6IRV8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038943932   ⟸   XM_039088004
- Peptide Label: isoform X3
- UniProtKB: Q62696 (UniProtKB/Swiss-Prot),   A0A0G2K1M2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038943931   ⟸   XM_039088003
- Peptide Label: isoform X2
- UniProtKB: Q62696 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038943948   ⟸   XM_039088020
- Peptide Label: isoform X17
- UniProtKB: Q62696 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038943947   ⟸   XM_039088019
- Peptide Label: isoform X16
- UniProtKB: A0A8I6A0H6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038943949   ⟸   XM_039088021
- Peptide Label: isoform X18
- UniProtKB: A0A8I6GMS2 (UniProtKB/TrEMBL),   A0A8I6A0H6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038943950   ⟸   XM_039088022
- Peptide Label: isoform X19
- UniProtKB: A0A8I6A0H6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038943952   ⟸   XM_039088024
- Peptide Label: isoform X22
- UniProtKB: A0A8I5ZVT1 (UniProtKB/TrEMBL),   A0A8I6A0H6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038943951   ⟸   XM_039088023
- Peptide Label: isoform X20
- UniProtKB: A0A8I6A0H6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038943953   ⟸   XM_039088025
- Peptide Label: isoform X23
- UniProtKB: A0A8I6A0H6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000081862   ⟸   ENSRNOT00000113230
Ensembl Acc Id: ENSRNOP00000088710   ⟸   ENSRNOT00000102386
Ensembl Acc Id: ENSRNOP00000085582   ⟸   ENSRNOT00000109975
Ensembl Acc Id: ENSRNOP00000097997   ⟸   ENSRNOT00000108927
Ensembl Acc Id: ENSRNOP00000091905   ⟸   ENSRNOT00000117728
RefSeq Acc Id: NP_001380663   ⟸   NM_001393734
- Peptide Label: isoform 2
- UniProtKB: A0A8I6A5M7 (UniProtKB/TrEMBL),   A6IRV5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126369   ⟸   XM_063270299
- Peptide Label: isoform X14
- UniProtKB: A6IRV5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126370   ⟸   XM_063270300
- Peptide Label: isoform X15
- UniProtKB: Q62696 (UniProtKB/Swiss-Prot),   A6IRV6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126368   ⟸   XM_063270298
- Peptide Label: isoform X8
- UniProtKB: Q62696 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063126373   ⟸   XM_063270303
- Peptide Label: isoform X25
- UniProtKB: A0A8I6A0H6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126372   ⟸   XM_063270302
- Peptide Label: isoform X24
- UniProtKB: A0A8I6A0H6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126371   ⟸   XM_063270301
- Peptide Label: isoform X21
- UniProtKB: A0A8I6A0H6 (UniProtKB/TrEMBL)
Protein Domains
Guanylate kinase-like   L27   PDZ   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62696-F1-model_v2 AlphaFold Q62696 1-911 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698221
Promoter ID:EPDNEW_R8744
Type:single initiation site
Name:Dlg1_1
Description:discs large MAGUK scaffold protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01172,378,806 - 72,378,866EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2505 AgrOrtholog
BioCyc Gene G2FUF-21064 BioCyc
Ensembl Genes ENSRNOG00000038597 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000078737 ENTREZGENE
  ENSRNOT00000102386 ENTREZGENE
  ENSRNOT00000108927 ENTREZGENE
  ENSRNOT00000109975 ENTREZGENE
  ENSRNOT00000113230 ENTREZGENE
  ENSRNOT00000117728 ENTREZGENE
Gene3D-CATH 2.30.42.10 UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot
  Guanylate Kinase phosphate binding domain UniProtKB/Swiss-Prot
  Helix hairpin bin UniProtKB/Swiss-Prot
  SH3 Domains UniProtKB/Swiss-Prot
InterPro DLG1-like UniProtKB/Swiss-Prot
  DLG1_PEST_dom UniProtKB/Swiss-Prot
  GK/Ca_channel_bsu UniProtKB/Swiss-Prot
  Guanylate_kin-like_dom UniProtKB/Swiss-Prot
  Guanylate_kinase_CS UniProtKB/Swiss-Prot
  L27_1 UniProtKB/Swiss-Prot
  L27_dom UniProtKB/Swiss-Prot
  L27_dom_sf UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
  PDZ_assoc UniProtKB/Swiss-Prot
  PDZ_sf UniProtKB/Swiss-Prot
  SH3-like_dom_sf UniProtKB/Swiss-Prot
  SH3_domain UniProtKB/Swiss-Prot
  Synaptic_Scaffolding_LAP-MAGUK UniProtKB/Swiss-Prot
KEGG Report rno:25252 UniProtKB/Swiss-Prot
NCBI Gene 25252 ENTREZGENE
PANTHER DISCS LARGE UniProtKB/Swiss-Prot
  DISKS LARGE HOMOLOG 1 UniProtKB/Swiss-Prot
Pfam Guanylate_kin UniProtKB/Swiss-Prot
  L27_1 UniProtKB/Swiss-Prot
  MAGUK_N_PEST UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
  PDZ_assoc UniProtKB/Swiss-Prot
  SH3_1 UniProtKB/Swiss-Prot
PhenoGen Dlg1 PhenoGen
PIRSF MAGUK_DLGH UniProtKB/Swiss-Prot
PROSITE GUANYLATE_KINASE_1 UniProtKB/Swiss-Prot
  GUANYLATE_KINASE_2 UniProtKB/Swiss-Prot
  L27 UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000038597 RatGTEx
SMART GuKc UniProtKB/Swiss-Prot
  L27 UniProtKB/Swiss-Prot
  MAGUK_N_PEST UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF101288 UniProtKB/Swiss-Prot
  SSF50044 UniProtKB/Swiss-Prot
  SSF50156 UniProtKB/Swiss-Prot
  SSF52540 UniProtKB/Swiss-Prot
TIGR TC205414
UniProt A0A0G2K1M2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZVT1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A0H6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A5M7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AG51_RAT UniProtKB/TrEMBL
  A0A8I6GMS2 ENTREZGENE, UniProtKB/TrEMBL
  A6IRV5 ENTREZGENE, UniProtKB/TrEMBL
  A6IRV6 ENTREZGENE, UniProtKB/TrEMBL
  A6IRV7 ENTREZGENE, UniProtKB/TrEMBL
  A6IRV8 ENTREZGENE, UniProtKB/TrEMBL
  DLG1_RAT UniProtKB/Swiss-Prot
  F1LNM0_RAT UniProtKB/TrEMBL
  Q62696 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-15 Dlg1  discs, large homolog 1 (Drosophila)  Dlgh1  discs, large homolog 1 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Dlgh1  discs, large homolog 1 (Drosophila)  Dlg1  Drosophila discs-large tumor suppressor homologue (synapse associated protein)  Name updated 625702 APPROVED
2002-06-10 Dlg1  Drosophila discs-large tumor suppressor homologue (synapse associated protein)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized in presynaptic nerve termini of excitatory synapses in the hypocampus at unmyelinated axons and at sites of contact among epithelial cells 1298878
gene_cellular_localization localized to and along bundles of unmyelinated axons at cytoplasmic surfaces of plasma membranes 1298878
gene_cellular_localization co-localizes with both ionotropic glutamate receptors (nucleus) and such downstream signaling proteins as Ca2+/calmodulin-dependent protein kinase II (CaMKII) 1298879
gene_expression may provide synaptic targeting for NMDA receptors 1298879
gene_homology has high similarity to rat sap90 1298878
gene_physical_interaction binds to the NR2A subunit of the NMDA receptor in its unphosphorylated form 1298879
gene_process may participate in cell adhesion and function in site-specific cellular activities 1298878
gene_process targets ionotropic glutamate receptors at postsynaptic sites 1298879
gene_product member of membrane-associated guanylate kinase protein family 1298879
gene_regulation phosphorylated by CaMKII via N-methyl-D-aspartic acid (NMDA) receptor activation 1298879