Ace (angiotensin I converting enzyme) - Rat Genome Database

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Gene: Ace (angiotensin I converting enzyme) Rattus norvegicus
Symbol: Ace
Name: angiotensin I converting enzyme
RGD ID: 2493
Description: Enables heterocyclic compound binding activity; metallopeptidase activity; and peptidyl-dipeptidase activity. Involved in several processes, including blood vessel diameter maintenance; negative regulation of transport; and response to corticosteroid. Located in several cellular components, including basal plasma membrane; brush border membrane; and sperm midpiece. Used to study several diseases, including artery disease (multiple); glomerulonephritis (multiple); kidney failure (multiple); lung disease (multiple); and proteinuria (multiple). Biomarker of several diseases, including artery disease (multiple); congenital diaphragmatic hernia; endomyocardial fibrosis; liver cirrhosis (multiple); and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); gastrointestinal system cancer (multiple); heart valve disease (multiple); and lung disease (multiple). Orthologous to human ACE (angiotensin I converting enzyme); PARTICIPATES IN angiotensin (1-7) signaling pathway; renin-angiotensin cascade pathway; angiotensin II signaling pathway; INTERACTS WITH (+)-pilocarpine; (+)-schisandrin B; (R)-lipoic acid.
Type: protein-coding
Previously known as: angiotensin 1 converting enzyme; angiotensin 1 converting enzyme 1; angiotensin converting enzyme; angiotensin I converting enzyme (peptidyl-dipeptidase A) 1; angiotensin I converting enzyme 1; angiotensin I-converting enzyme (Dipeptidyl carboxypeptidase 1); angiotensin-converting enzyme; angiotensin-converting enzyme-like; CD143; Dcp1; Dipeptidyl carboxypeptidase 1; Dipeptidyl carboxypeptidase 1 (Angiotensin I-converting enzyme); dipeptidyl carboxypeptidase I; kininase II; LOC102556346; StsRR92
RGD Orthologs
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Aceem1Mcwi   Aceem2Mcwi  
Genetic Models: SS-Aceem1Mcwi SS-Aceem2Mcwi
Is Marker For: Strains:   SD-Tg(Ren2)27   SS.MNS-(D10M11Mit119-D10Mit11)/Jr   LOU.BN-(D10Mgh1-D10Mgh14)/Ins  
QTLs:   Bp9   Bw57   Bp342   Bw102  
Candidate Gene For: Bp1 Bp9 Bp72 Bp128 Bp342
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81091,410,129 - 91,430,246 (+)NCBIGRCr8
mRatBN7.21090,910,316 - 90,930,437 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1090,910,316 - 90,931,131 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1095,964,627 - 95,984,783 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01095,427,801 - 95,447,951 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01090,839,016 - 90,859,102 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01094,170,766 - 94,213,831 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1094,170,766 - 94,187,822 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01093,922,062 - 93,965,127 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41095,361,338 - 95,381,455 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1089,588,544 - 89,608,666 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (IMP)
Acute Hepatitis  (IEP)
acute kidney failure  (IMP)
Acute Lung Injury  (ISO)
adenocarcinoma  (ISO)
adult respiratory distress syndrome  (ISO)
Albuminuria  (IMP,ISO)
alcoholic cardiomyopathy  (ISO)
Alcoholic Liver Diseases  (ISO)
allergic disease  (ISO)
allergic rhinitis  (ISO)
Alzheimer's disease  (IMP,ISO)
anemia  (ISO)
Angiotensin I-Converting Enzyme, Benign Serum Increase  (ISO)
ankylosing spondylitis  (ISO)
Aortic Coarctation  (IEP)
Arteriovenous Fistula  (IEP,IMP)
aspiration pneumonia  (ISO)
asthma  (ISO)
atrial fibrillation  (ISO)
autistic disorder  (ISO)
autosomal recessive polycystic kidney disease  (IEP,IMP)
Banti's Syndrome  (ISO)
Behcet's disease  (ISO)
berylliosis  (ISO)
bipolar disorder  (IEA)
brain ischemia  (ISO)
breast cancer  (ISO)
bronchiolitis obliterans  (IMP)
Cardiac Arrhythmias  (ISO)
Cardiomegaly  (IMP)
cardiovascular system disease  (ISO)
carotid artery disease  (ISO)
celiac disease  (ISO)
Cerebral Hemorrhage  (ISO)
cerebral infarction  (ISO)
Chemical and Drug Induced Liver Injury  (IEP)
chemical colitis  (ISO)
Chemotherapy-Induced Febrile Neutropenia  (ISO)
cholestasis  (IEP)
Chronic Hepatitis C  (IEP,ISO)
Chronic Intermittent Hypoxia  (IEP)
chronic myeloid leukemia  (ISO)
chronic obstructive pulmonary disease  (ISO)
congenital diaphragmatic hernia  (IEP)
Congenital Hepatic Fibrosis  (IEP)
congestive heart failure  (IEP,IMP,ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
coronary restenosis  (ISO)
Coronavirus infectious disease  (ISO)
Cough  (ISO)
Cytomegalovirus Infections  (ISO)
diabetic angiopathy  (ISO)
Diabetic Cardiomyopathies  (IEP)
Diabetic Nephropathies  (IDA,IMP,ISO)
diabetic retinopathy  (ISO)
diastolic heart failure  (IMP,ISO)
diffuse cystic renal dysplasia  (ISO)
dilated cardiomyopathy  (ISO)
drug allergy  (ISO)
end stage renal disease  (IMP,ISO)
endomyocardial fibrosis  (IEP)
Endotoxemia  (IEP)
Experimental Arthritis  (IEP)
Experimental Colitis  (ISO)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Liver Cirrhosis  (IEP)
extrinsic allergic alveolitis  (ISO)
Fabry disease  (ISO)
Familial Cerebral Cavernous Malformation  (ISO)
familial Mediterranean fever  (ISO)
Fetal Death  (ISO)
Fetal Growth Retardation  (IEP)
focal segmental glomerulosclerosis 1  (IMP)
gallbladder adenocarcinoma  (ISO)
Gaucher's disease  (ISO)
genetic disease  (ISO)
Genetic Predisposition to Disease  (ISO)
glomerulonephritis  (IMP)
glomerulosclerosis  (IMP)
glycogen storage disease V  (ISO)
heart valve disease  (ISO)
Helicobacter Infections  (ISO)
Henoch-Schoenlein purpura  (ISO)
hepatitis A  (ISO)
hepatocellular carcinoma  (ISO)
Hyperoxia  (IEP)
hypertension  (IDA,IEP,IMP,ISO)
Hypertensive Nephrosclerosis  (IMP,ISO)
hypertrophic cardiomyopathy  (ISO)
Hypotension  (ISO)
IgA glomerulonephritis  (ISO)
in situ carcinoma  (ISO)
Insulin Resistance  (ISO)
intermediate coronary syndrome  (ISO)
Intestinal Reperfusion Injury  (IEP)
intracranial aneurysm  (ISO)
kidney disease  (ISO)
kidney failure  (ISO)
Kidney Reperfusion Injury  (IMP)
Left Ventricular Hypertrophy  (IEP,IMP,ISO)
leukemia  (ISO)
leukostasis  (IMP)
liver cirrhosis  (IEP,ISO)
Liver Metastasis  (ISO)
lung cancer  (ISO)
lung carcinoma  (ISO)
lung disease  (IEP,IMP,ISO)
Lung Injury  (ISO)
Lung Neoplasms  (ISO)
malaria  (ISO)
male infertility  (ISO)
Memory Disorders  (IMP,ISO)
Meningococcal Infections  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
microcephaly  (ISO)
middle cerebral artery infarction  (IMP)
mitral valve disease  (ISO)
mitral valve prolapse  (ISO)
multiple myeloma  (ISO)
Mycobacterium Infections  (ISO)
myocardial infarction  (IEP,IMP,ISO)
myocarditis  (IMP)
Neoplasm Metastasis  (ISO)
nephritis  (ISO)
nephrosis  (IEP,IMP)
nephrotic syndrome  (IDA,IMP)
non-arteritic anterior ischemic optic neuropathy  (ISO)
obesity  (IEP,ISO)
obstructive sleep apnea  (IEP,ISO)
ocular hypotension  (IMP)
osteoporosis  (IMP)
Pain  (IMP)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
Parkinson's disease  (ISO)
Peritoneal Fibrosis  (IMP,ISO)
Pleural Effusion  (ISO)
pneumonia  (ISO)
polycythemia  (ISO)
pre-eclampsia  (ISO)
pre-malignant neoplasm  (IMP)
Pregnancy-Induced Hypertension  (IEP)
Premature Infant Diseases  (ISO)
Prenatal Exposure Delayed Effects  (IEP)
primary biliary cholangitis  (IEP)
Prostatic Neoplasms  (ISO)
proteinuria  (IMP,ISO)
pulmonary fibrosis  (IEP,IMP,ISO)
pulmonary hypertension  (ISO)
Puromycin Aminonucleoside Nephrosis  (IMP)
pyelonephritis  (ISO)
Radiation Nephropathy  (IMP)
renal fibrosis  (IMP,ISO)
Renal Tubular Dysgenesis  (ISO)
renovascular hypertension  (IDA,IEP)
Reperfusion Injury  (IMP)
respiratory system disease  (ISO)
Right Ventricular Hypertrophy  (IEP)
sarcoidosis  (ISO)
schizophrenia  (ISO)
Sepsis  (ISO)
severe acute respiratory syndrome  (ISO)
Staphylococcal Infections  (ISO)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
Stroke  (IMP,ISO)
subacute sclerosing panencephalitis  (ISO)
substance-induced psychosis  (ISO)
Sudden Death  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
toxic shock syndrome  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
ureteral obstruction  (IMP)
uveitis  (ISO)
Vascular System Injuries  (IAGP,ISO)
Venous Thromboembolism  (ISO)
Ventricular Fibrillation  (IMP)
Ventricular Remodeling  (IDA)
viral pneumonia  (ISO)
Weight Gain  (ISO)
Weight Loss  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(+)-schisandrin B  (EXP)
(+)-trans-(S)-allethrin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-lipoic acid  (EXP,ISO)
(S)-colchicine  (EXP)
(S)-nicotine  (ISO)
(S,S,S)-nicotianamine  (ISO)
1,10-phenanthroline  (ISO)
1,2-dimethylhydrazine  (ISO)
14,15-EET  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,5-dihydroxybenzoic acid  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile  (EXP)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
Ac-Ser-Asp-Lys-Pro-OH  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrylamide  (ISO)
actinomycin D  (EXP)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (EXP)
aluminium atom  (ISO)
aluminium(0)  (ISO)
aminoguanidine  (ISO)
amitrole  (EXP)
amlodipine  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
atorvastatin calcium  (EXP)
atrazine  (ISO)
benazepril  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-naphthoflavone  (EXP)
bezafibrate  (EXP)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP)
boric acid  (ISO)
bortezomib  (ISO)
Butralin  (EXP)
cadmium dichloride  (EXP)
caffeine  (EXP)
candesartan  (EXP)
cannabidiol  (ISO)
captan  (ISO)
captopril  (EXP,ISO)
carbon nanotube  (ISO)
carvedilol  (EXP,ISO)
chromium atom  (EXP)
chromium(6+)  (ISO)
cilazapril monohydrate  (ISO)
cisplatin  (EXP)
cobalt dichloride  (ISO)
cocaine  (ISO)
corticosterone  (EXP)
Cuprizon  (EXP)
curcumin  (EXP)
cyclophosphamide  (EXP)
D-glucose  (EXP,ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (ISO)
doxorubicin  (EXP)
EC (peptidyl-dipeptidase A) inhibitor  (EXP)
enalapril  (EXP,ISO)
enalaprilat dihydrate  (ISO)
ethanol  (EXP)
ethylbenzene  (ISO)
ethylenediaminetetraacetic acid  (ISO)
fenvalerate  (ISO)
flavonoids  (EXP)
folic acid  (EXP,ISO)
folpet  (ISO)
formaldehyde  (ISO)
fructose  (EXP)
furan  (EXP)
genistein  (EXP)
gentamycin  (EXP)
glucose  (EXP,ISO)
glycidol  (EXP)
goralatide  (ISO)
GW 4064  (ISO)
herbimycin  (ISO)
hydralazine  (EXP)
hydrazines  (ISO)
hydrochlorothiazide  (EXP)
hydrogen peroxide  (ISO)
indometacin  (ISO)
indoxyl sulfate  (EXP)
inulin  (ISO)
isoprenaline  (EXP)
ketamine  (EXP)
L-ascorbic acid  (ISO)
Lasiocarpine  (ISO)
lead diacetate  (EXP)
lead(0)  (EXP)
lipoic acid  (EXP,ISO)
lisinopril dihydrate  (ISO)
lithium chloride  (EXP)
losartan  (EXP,ISO)
lycopene  (EXP)
Magnolol  (EXP)
maneb  (ISO)
manganese(II) chloride  (EXP)
manidipine  (EXP)
metformin  (ISO)
methoxychlor  (EXP)
metoprolol  (ISO)
microcystin RR  (ISO)
mifepristone  (EXP)
monocrotaline  (EXP)
N(4)-hydroxycytidine  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methylnicotinate  (EXP,ISO)
N-nitrosodiethylamine  (EXP)
Nandrolone decanoate  (EXP)
naringin  (EXP)
nicotianamine  (ISO)
nicotinamide  (ISO)
nicotine  (ISO)
nicotinic acid  (EXP)
nitric oxide  (EXP)
nitrofen  (EXP)
NS-398  (ISO)
oleuropein  (EXP)
oltipraz  (EXP,ISO)
omapatrilat  (ISO)
Ondansetron  (EXP)
ouabain  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perindopril  (ISO)
phenylephrine  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (EXP)
pirfenidone  (EXP)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
pravastatin  (EXP)
pregabalin  (EXP)
proanthocyanidin  (EXP)
prostaglandin E2  (ISO)
prostaglandin I2  (ISO)
quercetin  (EXP,ISO)
quinapril hydrochloride  (EXP,ISO)
raloxifene  (ISO)
ramipril  (EXP,ISO)
rebaudioside A  (ISO)
resveratrol  (EXP,ISO)
rivastigmine  (EXP)
silicon dioxide  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
spironolactone  (EXP)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (EXP,ISO)
sunitinib  (ISO)
telmisartan  (EXP)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP)
titanium dioxide  (EXP,ISO)
toluene  (ISO)
trandolapril  (EXP)
tributylstannane  (ISO)
triclosan  (ISO)
triptonide  (ISO)
tyrphostin AG 1478  (EXP)
valproic acid  (ISO)
valsartan  (EXP)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
amyloid-beta metabolic process  (IEA,ISO)
angiogenesis involved in coronary vascular morphogenesis  (IMP)
angiotensin maturation  (IEA,ISO,ISS)
angiotensin-activated signaling pathway  (IEA,ISO)
animal organ regeneration  (IMP)
arachidonic acid secretion  (IEA,ISO)
bradykinin catabolic process  (IDA,IEA,IMP,ISO)
cell proliferation in bone marrow  (IEA,ISO)
cellular response to aldosterone  (IEP)
cellular response to glucose stimulus  (IEP)
eating behavior  (IMP)
embryo development ending in birth or egg hatching  (IMP)
female pregnancy  (IEP)
heart contraction  (IEA,ISO)
hormone catabolic process  (IEA,ISO,ISS)
hormone metabolic process  (ISO,ISS)
kidney development  (IEA,IEP,ISO,ISS)
lung alveolus development  (IMP)
lung development  (IEP)
male gonad development  (IEA,IEP,ISO)
negative regulation of calcium ion import  (IMP)
negative regulation of gap junction assembly  (IEA,ISO)
negative regulation of gene expression  (IEA,ISO)
negative regulation of glucose import  (IMP)
neutrophil mediated immunity  (IEA,ISO)
peptide catabolic process  (IDA,ISO)
peptide metabolic process  (IMP)
positive regulation of apoptotic process  (IMP)
positive regulation of blood pressure  (IMP)
positive regulation of neurogenesis  (IMP)
positive regulation of peptidyl-cysteine S-nitrosylation  (IEA,ISO)
positive regulation of systemic arterial blood pressure  (IBA,IEA,IMP,ISO)
positive regulation of vasoconstriction  (IMP)
post-transcriptional regulation of gene expression  (IEA,ISO)
proteolysis  (IEA)
regulation of angiotensin metabolic process  (IEA,ISO)
regulation of blood pressure  (IDA,ISO,TAS)
regulation of heart rate by cardiac conduction  (IEA,ISO)
regulation of hematopoietic stem cell proliferation  (IEA,ISO)
regulation of smooth muscle cell migration  (IDA)
regulation of synaptic plasticity  (IEA,ISO,ISS)
regulation of systemic arterial blood pressure by renin-angiotensin  (IBA,ISO)
response to dexamethasone  (IEP)
response to hypoxia  (IEP)
response to laminar fluid shear stress  (IEP)
response to lipopolysaccharide  (IMP)
response to nutrient levels  (IEP)
response to thyroid hormone  (IEP)
response to xenobiotic stimulus  (IEP)
spermatogenesis  (IEA,ISO)
substance P catabolic process  (IEA,ISO,ISS)
vasoconstriction  (IMP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References - curated
# Reference Title Reference Citation
1. Protective effect of captopril against clozapine-induced myocarditis in rats: role of oxidative stress, proinflammatory cytokines and DNA damage. Abdel-Wahab BA, etal., Chem Biol Interact. 2014 Jun 5;216:43-52. doi: 10.1016/j.cbi.2014.03.012. Epub 2014 Apr 5.
2. Mechanisms of angiotensin converting enzyme inhibitor-induced IOP reduction in normotensive rats. Agarwal R, etal., Eur J Pharmacol. 2014 May 5;730:8-13. doi: 10.1016/j.ejphar.2014.02.021. Epub 2014 Feb 26.
3. Is serum angiotensin converting enzyme level a useful non-invasive marker for liver fibrosis in patients with chronic hepatitis C? Akar T, Rev Assoc Med Bras (1992). 2018 Mar;64(3):224-229. doi: 10.1590/1806-9282.64.03.224.
4. The effect of maternal administration of captopril on fetal development in rat. al-Shabanah OA, etal., Res Commun Chem Pathol Pharmacol. 1991 Aug;73(2):221-30.
5. Elevated serum angiotensin converting enzyme levels as a reflection of bone marrow renin-angiotensin system activation in multiple myeloma. Albayrak M, etal., J Renin Angiotensin Aldosterone Syst. 2012 Jun;13(2):259-64. doi: 10.1177/1470320312437070. Epub 2012 Feb 16.
6. Angiotensin-converting enzyme insertion/deletion gene polymorphism in patients with familial multiple cerebral cavernous malformations. Altas M, etal., J Clin Neurosci. 2010 Aug;17(8):1034-7. doi: 10.1016/j.jocn.2009.12.002. Epub 2010 May 21.
7. Effects of blockade of the renin-angiotensin and endothelin systems on experimental bronchiolitis obliterans. Antus B, etal., J Heart Lung Transplant. 2006 Nov;25(11):1324-9.
8. Antihypertensives as novel antineoplastics: angiotensin-I-converting enzyme inhibitors and angiotensin II type 1 receptor blockers in pancreatic ductal adenocarcinoma. Arafat HA, etal., J Am Coll Surg. 2007 May;204(5):996-1005; discussion 1005-6.
9. Angiotensin I-converting enzyme activity in puromycin aminonucleoside-nephrotic syndrome. Arevalo AE, etal., Clin Chim Acta. 1990 Nov 5;191(3):175-84.
10. Angiotensin-converting enzyme genotype predicts valve damage in acute rheumatic fever. Atalar E, etal., J Heart Valve Dis. 2003 Jan;12(1):7-10.
11. Polymorphism of angiotensin converting enzyme is associated with severe circulatory compromise in febrile neutropenic children with cancer. Bardi E, etal., Pediatr Blood Cancer. 2005 Aug;45(2):217-21.
12. ACE activity is modulated by the enzyme a-galactosidase A. Batista EC, etal., J Mol Med (Berl). 2011 Jan;89(1):65-74. doi: 10.1007/s00109-010-0686-2. Epub 2010 Oct 13.
13. Effects on cytokines and histology by treatment with the ACE inhibitor captopril and the antioxidant retinoic acid in the monocrotaline model of experimentally induced lung fibrosis. Baybutt RC, etal., Curr Pharm Des. 2007;13(13):1327-33.
14. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
15. No contribution of angiotensin-converting enzyme (ACE) gene variants to severe obesity: a model for comprehensive case/control and quantitative cladistic analysis of ACE in human diseases. Bell CG, etal., Eur J Hum Genet. 2007 Mar;15(3):320-7. Epub 2006 Dec 13.
16. Inhibiting angiotensin-converting enzyme promotes renal repair by limiting progenitor cell proliferation and restoring the glomerular architecture. Benigni A, etal., Am J Pathol. 2011 Aug;179(2):628-38. doi: 10.1016/j.ajpath.2011.04.003. Epub 2011 Jun 2.
17. Beneficial effect of TGFbeta antagonism in treating diabetic nephropathy depends on when treatment is started. Benigni A, etal., Nephron Exp Nephrol. 2006;104(4):e158-68. Epub 2006 Aug 10.
18. Separate metabolic pathways for Leu-enkephalin and Met-enkephalin-Arg(6)-Phe(7) degradation by rat striatal synaptosomal membranes. Benuck M, etal., Neurochem Int. 1982;4(5):389-96. doi: 10.1016/0197-0186(82)90081-x.
19. Elevated levels of circulating angiotensin converting enzyme in patients with hepatoportal sclerosis. Beyazit Y, etal., Dig Dis Sci. 2011 Jul;56(7):2160-5. doi: 10.1007/s10620-011-1580-7. Epub 2011 Feb 3.
20. Comparison of the incidence of imidapril and enalapril induced cough. Boonyapisit W and Tresukosol D, J Med Assoc Thai. 2010 Jan;93 Suppl 1:S48-53.
21. Involvement of renal ACE activity in proteinuria-associated renal damage in untreated and treated adriamycin nephrotic rats. Bos H, etal., J Renin Angiotensin Aldosterone Syst 2003 Jun;4(2):106-12.
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163. Insertion/deletion polymorphism and serum activity of the angiotensin-converting enzyme in Turkish patients with obstructive sleep apnea syndrome. Ogus C, etal., Biochem Genet. 2010 Jun;48(5-6):516-23. Epub 2010 Feb 25.
164. Effects of an angiotensin-converting enzyme inhibitor-based regimen on pneumonia risk. Ohkubo T, etal., Am J Respir Crit Care Med. 2004 May 1;169(9):1041-5. Epub 2004 Feb 27.
165. Modulation of plasminogen activator inhibitor-1 in vivo: a new mechanism for the anti-fibrotic effect of renin-angiotensin inhibition. Oikawa T, etal., Kidney Int. 1997 Jan;51(1):164-72.
166. Lisinopril reduces cardiac hypertrophy and mortality in rats with aortocaval fistula. Oka T, etal., Eur J Pharmacol. 1993 Mar 30;234(1):55-60.
167. Antenatal glucocorticoid therapy suppresses angiotensin-converting enzyme activity in rats with nitrofen-induced congenital diaphragmatic hernia. Okoye BO, etal., J Pediatr Surg. 1998 Feb;33(2):286-91.
168. Mild but prolonged elevation of serum angiotensin converting enzyme (ACE) activity in alcoholics. Okuno F, etal., Alcohol. 1986 Nov-Dec;3(6):357-9. doi: 10.1016/0741-8329(86)90053-4.
169. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
170. The renin-angiotensin system genetic polymorphisms and rheumatic mitral valve disease. Ozisik K, etal., J Heart Valve Dis. 2004 Jan;13(1):33-7.
171. Angiotensin-converting enzyme gene polymorphism in Behcet's disease. Ozturk MA, etal., Clin Rheumatol. 2004 Apr;23(2):142-6. Epub 2004 Feb 24.
172. Angiotensin-converting enzyme I/D polymorphism in chronic obstructive pulmonary disease. Pabst S, etal., Eur J Med Res. 2009 Dec 7;14 Suppl 4:177-81.
173. Enalapril attenuates ischaemic brain oedema and protects the blood-brain barrier in rats via an anti-oxidant action. Panahpour H, etal., Clin Exp Pharmacol Physiol. 2014 Mar;41(3):220-6. doi: 10.1111/1440-1681.12210.
174. Polymorphism of the ACE Gene in dialysis patients: overexpression of DD genotype in type 2 diabetic end-stage renal failure patients. Park HC, etal., Yonsei Med J. 2005 Dec 31;46(6):779-87.
175. Effects of captopril and angiotensin II receptor blockers (AT1, AT2) on myocardial ischemia-reperfusion induced infarct size. Parlakpinar H, etal., Cytokine. 2011 Dec;56(3):688-94. Epub 2011 Oct 4.
176. Gene polymorphisms and febrile neutropenia in acute leukemia--no association with IL-4, CCR-5, IL-1RA, but the MBL-2, ACE, and TLR-4 are associated with the disease in Turkish patients: a preliminary study. Pehlivan M, etal., Genet Test Mol Biomarkers. 2014 Jul;18(7):474-81. doi: 10.1089/gtmb.2014.0004. Epub 2014 May 12.
177. Reduced circulating levels of angiotensin-(1--7) in systemic sclerosis: a new pathway in the dysregulation of endothelial-dependent vascular tone control. Pignone A, etal., Ann Rheum Dis. 2007 Oct;66(10):1305-10. Epub 2007 Mar 14.
178. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
179. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
180. Angiotensin-converting enzyme inhibitor versus angiotensin II, AT1 receptor antagonist. Effects on smooth muscle cell migration and proliferation after balloon catheter injury. Prescott MF, etal., Am J Pathol. 1991 Dec;139(6):1291-6.
181. Diminazene aceturate enhances angiotensin-converting enzyme 2 activity and attenuates ischemia-induced cardiac pathophysiology. Qi Y, etal., Hypertension. 2013 Oct;62(4):746-52. doi: 10.1161/HYPERTENSIONAHA.113.01337. Epub 2013 Aug 19.
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183. Renin-angiotensin polymorphisms and QTc interval prolongation in end-stage renal disease. Raizada V, etal., Kidney Int. 2005 Sep;68(3):1186-9.
184. Atrial fibrosis in a chronic murine model of obstructive sleep apnea: mechanisms and prevention by mesenchymal stem cells. Ramos P, etal., Respir Res. 2014 Apr 28;15:54. doi: 10.1186/1465-9921-15-54.
185. [Angiotensin converting enzyme and left ventricular hypertrophy in uremic patients: correlation and therapeutic options]. Rasic S, etal., Acta Med Croatica. 2004;58(3):193-6.
186. GOA pipeline RGD automated data pipeline
187. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
188. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
189. Role of angiotensin II in ischemia/reperfusion-induced leukocyte-endothelium interactions in the colon. Riaz AA, etal., FASEB J. 2004 May;18(7):881-3. doi: 10.1096/fj.03-0502fje. Epub 2004 Mar 4.
190. Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism. Rice GI, etal., Biochem J. 2004 Oct 1;383(Pt 1):45-51.
191. Suppression of angiotensin-converting enzyme expression and activity by shear stress. Rieder MJ, etal., Circ Res. 1997 Mar;80(3):312-9.
192. Novel natural peptide substrates for endopeptidase 24.15, neurolysin, and angiotensin-converting enzyme. Rioli V, etal., J Biol Chem. 2003 Mar 7;278(10):8547-55. doi: 10.1074/jbc.M212030200. Epub 2002 Dec 24.
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194. N-domain angiotensin-converting enzyme isoform expression in tissues of Wistar and spontaneously hypertensive rats. Ronchi FA, etal., J Hypertens. 2005 Oct;23(10):1869-78.
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198. Local corticosterone production and angiotensin-I converting enzyme shedding in a mouse model of intestinal inflammation. Salmenkari H, etal., World J Gastroenterol. 2015 Sep 21;21(35):10072-9. doi: 10.3748/wjg.v21.i35.10072.
199. An experimental model of encapsulating peritoneal sclerosis. Sawada T, etal., Perit Dial Int. 2009 Feb;29 Suppl 2:S49-50.
200. Effects of imatinib mesylate on renin-angiotensin system (RAS) activity during the clinical course of chronic myeloid leukaemia. Sayitoglu M, etal., J Int Med Res. 2009 Jul-Aug;37(4):1018-28.
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206. The ACE2/Ang-(1-7)/Mas Axis Confers Cardiopulmonary Protection against Lung Fibrosis and Pulmonary Hypertension. Shenoy V, etal., Am J Respir Crit Care Med. 2010 Jun 25.
207. Prevention of osteoporosis by angiotensin-converting enzyme inhibitor in spontaneous hypertensive rats. Shimizu H, etal., Hypertens Res. 2009 Sep;32(9):786-90. Epub 2009 Jul 10.
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247. Renin-angiotensin system gene polymorphisms and diastolic heart failure. Wu CK, etal., Eur J Clin Invest. 2008 Nov;38(11):789-97. doi: 10.1111/j.1365-2362.2008.02017.x.
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Additional References at PubMed
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Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81091,410,129 - 91,430,246 (+)NCBIGRCr8
mRatBN7.21090,910,316 - 90,930,437 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1090,910,316 - 90,931,131 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1095,964,627 - 95,984,783 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01095,427,801 - 95,447,951 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01090,839,016 - 90,859,102 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01094,170,766 - 94,213,831 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1094,170,766 - 94,187,822 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01093,922,062 - 93,965,127 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41095,361,338 - 95,381,455 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1089,588,544 - 89,608,666 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381763,477,061 - 63,498,373 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1763,477,061 - 63,498,380 (+)EnsemblGRCh38hg38GRCh38
GRCh371761,554,422 - 61,575,734 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361758,908,166 - 58,928,711 (+)NCBINCBI36Build 36hg18NCBI36
Build 341758,915,908 - 58,952,935NCBI
Celera1755,942,475 - 55,963,778 (+)NCBICelera
Cytogenetic Map17q23.3NCBI
HuRef1756,922,781 - 56,944,100 (+)NCBIHuRef
CHM1_11761,618,550 - 61,639,869 (+)NCBICHM1_1
T2T-CHM13v2.01764,347,269 - 64,368,872 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm3911105,858,774 - 105,880,790 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11105,858,771 - 105,880,790 (+)EnsemblGRCm39 Ensembl
GRCm3811105,967,948 - 105,989,964 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11105,967,945 - 105,989,964 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711105,829,261 - 105,851,259 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611105,784,049 - 105,805,350 (+)NCBIMGSCv36mm8
Celera11117,699,475 - 117,721,491 (+)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1168.84NCBI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v21979,648,057 - 79,669,151 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11784,465,633 - 84,486,649 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01757,556,294 - 57,577,294 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11762,710,398 - 62,724,018 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1762,702,341 - 62,733,853 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1911,497,182 - 11,516,362 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl911,497,182 - 11,516,358 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha912,457,866 - 12,477,045 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0913,160,704 - 13,179,888 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl913,160,704 - 13,200,795 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1912,105,344 - 12,124,523 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0915,407,255 - 15,426,429 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0915,410,134 - 15,429,354 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440560215,017,159 - 15,036,742 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365414,157,393 - 4,178,177 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365414,157,847 - 4,178,156 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1215,394,487 - 15,414,703 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11215,394,487 - 15,414,609 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21215,381,362 - 15,401,171 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_004624849998,277 - 1,019,521 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624849998,262 - 1,019,305 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Ace
84 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107255241693995749Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107437208494965338Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608594965338Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)107877551698279596Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108051528791230079Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1080515287101325465Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108256485692369470Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108400727295933025Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108400727295933025Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)108402232193995963Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1085565469103884409Rat
631538Oia5Oil induced arthritis QTL 5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087055121107211142Rat
2313856Bp342Blood pressure QTL 3424.40.0001life span trait (VT:0005372)age at time of death (CMO:0001193)108730761796121100Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087307617107211142Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1088539139107211142Rat
1558652Bw57Body weight QTL 574.20.0008body mass (VT:0001259)body weight (CMO:0000012)108932701790930437Rat
12880395Cm109Cardiac mass QTL 1090.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1090404397107211142Rat
12880396Am13Aortic mass QTL 130.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1090404397107211142Rat
12880398Kidm67Kidney mass QTL 670.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1090404397107211142Rat
12880384Cm107Cardiac mass QTL 1070.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)90404397107211142Rat
12880385Cm108Cardiac mass QTL 1080.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)90404397107211142Rat
1579915Bp280Blood pressure QTL 2800.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090404397107211142Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1090627439107057807Rat
724530Bp149Blood pressure QTL 1490.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090627439107211142Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01093,929,621 - 93,929,812NCBIRnor5.0
RGSC_v3.41095,368,898 - 95,369,088RGDRGSC3.4
RGSC_v3.11095,383,268 - 95,383,458RGD
SHRSP x BN Map1068.71RGD
SHRSP x BN Map1068.71UniSTS
FHH x ACI Map1075.81RGD
Cytogenetic Map10q32.1UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01094,178,338 - 94,178,506NCBIRnor6.0
Rnor_5.01093,929,634 - 93,929,802UniSTSRnor5.0
RGSC_v3.41095,368,909 - 95,369,078RGDRGSC3.4
RGSC_v3.41095,368,910 - 95,369,078UniSTSRGSC3.4
RGSC_v3.11095,383,279 - 95,383,448RGD
Celera1089,596,121 - 89,596,289UniSTS
RH 3.4 Map10978.1UniSTS
RH 3.4 Map10978.1RGD
RH 2.0 Map101075.9RGD
Cytogenetic Map10q32.1UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21090,930,321 - 90,930,437 (+)MAPPERmRatBN7.2
Rnor_6.01094,084,710 - 94,084,825NCBIRnor6.0
Rnor_5.01093,840,108 - 93,840,223UniSTSRnor5.0
RGSC_v3.41095,381,340 - 95,381,455UniSTSRGSC3.4
Celera1089,608,551 - 89,608,666UniSTS
Cytogenetic Map10q32.1UniSTS

Related Rat Strains
The following Strains have been annotated to Ace

Genetic Models
This gene Ace is modified in the following models/strains:


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hepatobiliary system nervous system renal system reproductive system
Medium 23 10 15
Low 30 2 2 2 40 14 15
Below cutoff 2 20 20 20


RefSeq Acc Id: ENSRNOT00000010627   ⟹   ENSRNOP00000010627
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1090,910,316 - 90,930,476 (+)Ensembl
Rnor_6.0 Ensembl1094,170,766 - 94,187,822 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000092961
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1090,917,450 - 90,930,476 (+)Ensembl
Rnor_6.0 Ensembl1094,177,889 - 94,187,822 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000119881   ⟹   ENSRNOP00000084667
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1090,910,316 - 90,931,131 (+)Ensembl
RefSeq Acc Id: NM_012544   ⟹   NP_036676
Rat AssemblyChrPosition (strand)Source
GRCr81091,410,129 - 91,430,246 (+)NCBI
mRatBN7.21090,910,316 - 90,930,437 (+)NCBI
Rnor_6.01094,170,766 - 94,213,831 (+)NCBI
Rnor_5.01093,922,062 - 93,965,127 (+)NCBI
RGSC_v3.41095,361,338 - 95,381,455 (+)RGD
Celera1089,588,544 - 89,608,666 (+)RGD
RefSeq Acc Id: NP_036676   ⟸   NM_012544
- Peptide Label: precursor
- UniProtKB: Q9EQM9 (UniProtKB/Swiss-Prot),   Q8CFN1 (UniProtKB/Swiss-Prot),   Q7TMC6 (UniProtKB/Swiss-Prot),   P47820 (UniProtKB/Swiss-Prot),   A6HJZ3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000010627   ⟸   ENSRNOT00000010627
RefSeq Acc Id: ENSRNOP00000084667   ⟸   ENSRNOT00000119881
Protein Domains
Peptidase M2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure Video
AF-P47820-F1-model_v2 AlphaFold P47820 1-1313 view protein structure  
ACE N-Terminal pdb 2c6f P47820 36-636 view protein structure  
ACE C-Terminal pdb 108a P47820 637-1238 view protein structure view video


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13697829
Promoter ID:EPDNEW_R8353
Type:multiple initiation site
Description:angiotensin I converting enzyme
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Alternative Promoters:null; see alsoEPDNEW_R8354  
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01094,170,755 - 94,170,815EPDNEW
RGD ID:13697846
Promoter ID:EPDNEW_R8354
Type:multiple initiation site
Description:angiotensin I converting enzyme
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Alternative Promoters:null; see alsoEPDNEW_R8353  
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01094,177,884 - 94,177,944EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2493 AgrOrtholog
BioCyc Gene G2FUF-22971 BioCyc
Ensembl Genes ENSRNOG00000062101 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055029388 UniProtKB/Swiss-Prot
  ENSRNOG00060013753 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000010627 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000010627.9 UniProtKB/Swiss-Prot
  ENSRNOT00000092961.2 UniProtKB/TrEMBL
  ENSRNOT00000119881.1 UniProtKB/TrEMBL
  ENSRNOT00055050997 UniProtKB/Swiss-Prot
  ENSRNOT00060023492 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.1370.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Peptidase_M2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24310 UniProtKB/Swiss-Prot
  PTHR10514 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Peptidase_M2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ace PhenoGen
  ZINC_PROTEASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000062101 RatGTEx
  ENSRNOG00055029388 RatGTEx
  ENSRNOG00060013753 RatGTEx
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt Secondary Q7TMC6 UniProtKB/Swiss-Prot
  Q8CFN1 UniProtKB/Swiss-Prot
  Q9EQM9 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Ace  angiotensin I converting enzyme  LOC102556346  angiotensin-converting enzyme-like  Data merged from RGD:7565702 737654 PROVISIONAL
2013-12-17 LOC102556346  angiotensin-converting enzyme-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-30 Ace  angiotensin I converting enzyme (peptidyl-dipeptidase A) 1    angiotensin 1 converting enzyme  Name updated 1299863 APPROVED
2004-12-14 Ace  angiotensin 1 converting enzyme    angiotensin 1 converting enzyme 1  Name updated 1299863 APPROVED
2002-06-10 Ace  angiotensin 1 converting enzyme 1      Symbol and Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease affects heart mass independent of blood pressure 1357231
gene_process functions in the renin-angiotensin system 61036
gene_process plays an important role in the regulation of blood volume and pressure 61036
gene_process level of plasma enzyme activity does not directly link to blood pressure 619632