Cyp2c11 (cytochrome P450, subfamily 2, polypeptide 11) - Rat Genome Database

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Gene: Cyp2c11 (cytochrome P450, subfamily 2, polypeptide 11) Rattus norvegicus
Analyze
Symbol: Cyp2c11
Name: cytochrome P450, subfamily 2, polypeptide 11
RGD ID: 2469
Description: Enables arachidonic acid 11,12-epoxygenase activity; arachidonic acid 14,15-epoxygenase activity; and testosterone 16-alpha-hydroxylase activity. Involved in epoxygenase P450 pathway and icosanoid biosynthetic process. Located in endoplasmic reticulum membrane. Biomarker of depressive disorder; end stage renal disease; and hypertension. Orthologous to human CYP2C18 (cytochrome P450 family 2 subfamily C member 18); PARTICIPATES IN forkhead class A signaling pathway; warfarin pharmacokinetics pathway; arachidonic acid metabolic pathway; INTERACTS WITH 1,2-dichloroethene; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Cyp2c; Cyp2c11l; CYP2CII; CYPIIC11; cytochrome P-450(M-1); cytochrome P450 2C11; cytochrome P450 2C11-like; cytochrome P450 2c29; cytochrome P450, 2c29; cytochrome P450, subfamily 2, polypeptide 11-like; cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase); cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 11; cytochrome P450-UT-2; cytochrome P450-UT-A; cytochrome P450H; LOC100911826; P-450(M-1); P450-UT-A; P450H; UT-2
RGD Orthologs
Human
Mouse
Dog
Green Monkey
Alliance Genes
More Info more info ...
Allele / Splice: Cyp2c11em1Nju  
Genetic Models: SD-Cyp2c11em1Nju
Candidate Gene For: Hcar5
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81246,175,216 - 246,211,445 (+)NCBIGRCr8
mRatBN7.21236,762,719 - 236,799,069 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1236,762,842 - 236,799,066 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1245,186,738 - 245,223,026 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01252,079,990 - 252,116,217 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01244,918,248 - 244,954,476 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01257,676,172 - 258,004,428 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1257,970,345 - 258,004,434 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01265,418,158 - 265,454,574 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41243,281,320 - 243,320,945 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1233,852,614 - 233,888,873 (+)NCBICelera
RH 3.4 Map11592.1RGD
Cytogenetic Map1q53NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1,1-Trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane  (ISO)
1,2-dichloroethene  (EXP)
1,4-naphthoquinone  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
2-nitrophenol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-methylcholanthrene  (EXP)
3-oxo-5beta-cholanic acid  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5,7-dihydroxy-4'-methoxyflavone  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-hydroxydiclofenac  (ISO)
5-Hydroxythalidomide  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
6-propyl-2-thiouracil  (EXP)
acenocoumarol  (ISO)
acetamide  (EXP)
acetonitrile  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (EXP)
alpha-hexachlorocyclohexane  (EXP)
alpha-naphthoflavone  (ISO)
amiodarone  (EXP,ISO)
ammonium chloride  (EXP)
amodiaquine  (ISO)
ampicillin  (EXP)
andrographolide  (EXP)
anthocyanin  (EXP)
aristolochic acid A  (EXP,ISO)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
atazanavir sulfate  (ISO)
atrazine  (EXP)
benzene  (EXP)
benzo[a]pyrene  (ISO)
Benzo[a]pyrene-7,8-oxide  (EXP)
benzophenone  (EXP)
beta-naphthoflavone  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bufuralol  (EXP)
butanal  (ISO)
Butylbenzyl phthalate  (EXP)
Butylparaben  (EXP)
C.I. Natural Red 20  (EXP)
cafestol  (EXP)
carvedilol  (EXP)
cefaloridine  (EXP)
chenodeoxycholic acid  (EXP,ISO)
chlorpromazine  (EXP,ISO)
chlorzoxazone  (EXP)
cholic acid  (EXP)
choline  (EXP)
cimetidine  (EXP)
ciprofloxacin  (EXP)
cisplatin  (EXP)
clofibric acid  (EXP)
clotrimazole  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
corticosterone  (EXP)
coumarin  (EXP)
crocidolite asbestos  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
dehydroepiandrosterone sulfate  (EXP)
deoxycholic acid  (EXP,ISO)
dexamethasone  (EXP)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
diethyl phthalate  (EXP)
dimethyl sulfoxide  (EXP)
dipropyl phthalate  (EXP)
disulfiram  (EXP)
doxorubicin  (EXP)
dronedarone  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP)
ethylbenzene  (EXP)
ethylparaben  (EXP)
farnesol  (EXP)
fenofibrate  (EXP)
flavonoids  (EXP)
fluconazole  (EXP)
fluoxetine  (EXP)
fulvestrant  (EXP,ISO)
Furafylline  (EXP)
furan  (EXP)
gadolinium trichloride  (EXP)
gamma-hexachlorocyclohexane  (EXP)
gemfibrozil  (EXP)
gentamycin  (EXP)
glafenine  (EXP)
glutathione  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
ifosfamide  (ISO)
indometacin  (EXP)
inulin  (ISO)
isoprenaline  (EXP)
kahweol  (EXP)
ketoconazole  (EXP)
kojic acid  (EXP)
L-methionine  (EXP)
lamotrigine  (EXP)
lansoprazole  (ISO)
lead nitrate  (EXP)
lithocholic acid  (EXP)
Luteolin 7-methyl ether  (EXP)
m-xylene  (EXP)
MeIQx  (EXP)
methapyrilene  (EXP)
methoxsalen  (EXP)
methoxychlor  (EXP,ISO)
methylarsonic acid  (EXP)
metronidazole  (EXP)
mitomycin C  (EXP)
mono(2-ethylhexyl) phthalate  (EXP)
monosodium L-glutamate  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nefazodone  (ISO)
neomycin  (EXP)
nevirapine  (EXP)
nifedipine  (EXP)
Nonylphenol  (EXP)
ochratoxin A  (EXP)
oltipraz  (EXP)
oxycodone  (EXP)
ozone  (EXP)
paracetamol  (EXP,ISO)
Paraoxon-methyl  (EXP)
parathion-methyl  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenacetin  (EXP)
phenobarbital  (EXP,ISO)
pirinixic acid  (EXP,ISO)
poly(I:C)  (EXP)
polymyxin B2  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
prochloraz  (EXP)
profenofos  (EXP)
progesterone  (ISO)
propanal  (ISO)
propiconazole  (EXP)
propylbenzene  (EXP)
propylparaben  (EXP)
pyrene  (EXP)
pyrimidin-2-amine  (EXP)
quinine  (EXP)
resveratrol  (ISO)
riddelliine  (EXP)
rifampicin  (ISO)
rotenone  (EXP)
senecionine  (ISO)
sevoflurane  (EXP)
Shikonin  (EXP)
silicon dioxide  (ISO)
simazine  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sporidesmin A  (ISO)
streptozocin  (EXP)
styrene  (EXP)
styrene oxide  (EXP)
Sudan I  (EXP)
Sudan III  (EXP)
sulfaphenazole  (EXP)
sunitinib  (EXP)
tamoxifen  (EXP)
tartrazine  (ISO)
taurocholic acid  (EXP)
testosterone  (EXP)
testosterone enanthate  (EXP)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
tolbutamide  (ISO)
toluene  (EXP)
torasemide  (EXP)
trans-1,2-dichloroethene  (EXP)
Tributyltin oxide  (EXP)
trichloroethene  (EXP)
triclosan  (ISO)
triflumuron  (ISO)
trimethylarsine oxide  (EXP)
Triptolide  (EXP)
uranium atom  (EXP)
ursodeoxycholic acid  (EXP)
vancomycin  (EXP)
verapamil  (EXP)
warfarin  (EXP,ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Eicosapentaenoic acid metabolism by cytochrome P450 enzymes of the CYP2C subfamily. Barbosa-Sicard E, etal., Biochem Biophys Res Commun. 2005 Apr 22;329(4):1275-81. doi: 10.1016/j.bbrc.2005.02.103.
2. cDNA-directed expression of two allelic variants of cytochrome P450 2C11 using COS1 and SF21 insect cells. Biagini C and Celier C, Arch Biochem Biophys 1996 Feb 15;326(2):298-305.
3. Use of analgesics and nonsteroidal anti-inflammatory drugs, genetic predisposition, and bladder cancer risk in Spain. Fortuny J, etal., Cancer Epidemiol Biomarkers Prev. 2006 Sep;15(9):1696-702.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Interaction of bisphenol A with rat hepatic cytochrome P450 enzymes. Hanioka N, etal., Chemosphere 2000 Oct;41(7):973-8.
7. The kidney cytochrome P-450 2C23 arachidonic acid epoxygenase is upregulated during dietary salt loading. Holla VR, etal., J Clin Invest. 1999 Sep;104(6):751-60. doi: 10.1172/JCI7013.
8. Association between CYP2C9 slow metabolizer genotypes and severe hypoglycaemia on medication with sulphonylurea hypoglycaemic agents. Holstein A, etal., Br J Clin Pharmacol. 2005 Jul;60(1):103-6.
9. CYP2C9 genotype and pharmacodynamic responses to losartan in patients with primary and secondary kidney diseases. Joy MS, etal., Eur J Clin Pharmacol. 2009 Sep;65(9):947-53. Epub 2009 Aug 11.
10. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
11. Hepatic drug metabolizing profile of Flinders Sensitive Line rat model of depression. Kotsovolou O, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2010 Aug 16;34(6):1075-84. Epub 2010 Jun 4.
12. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
13. Downregulation of hepatic cytochrome P450 in chronic renal failure. Leblond F, etal., J Am Soc Nephrol. 2001 Feb;12(2):326-32.
14. Failure to upregulate the adenosine2A receptor-epoxyeicosatrienoic acid pathway contributes to the development of hypertension in Dahl salt-sensitive rats. Liclican EL, etal., Am J Physiol Renal Physiol. 2008 Dec;295(6):F1696-704. Epub 2008 Oct 1.
15. Purification and characterization of three male-specific and one female-specific forms of cytochrome P-450 from rat liver microsomes. Matsumoto T, etal., J Biochem. 1986 Nov;100(5):1359-71. doi: 10.1093/oxfordjournals.jbchem.a121842.
16. Differential regulation of endobiotic-oxidizing cytochromes P450 in vitamin A-deficient male rat liver. Murray M, etal., Br J Pharmacol. 2001 Dec;134(7):1487-97. doi: 10.1038/sj.bjp.0704380.
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
21. GOA pipeline RGD automated data pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Changes of hepatic microsomal oxidative drug metabolizing enzymes in chronic renal failure (CRF) rats by partial nephrectomy. Uchida N, etal., Jpn J Pharmacol. 1995 Aug;68(4):431-9.
25. Generation and Characterization of a CYP2C11-Null Rat Model by Using the CRISPR/Cas9 Method. Wei Y, etal., Drug Metab Dispos. 2018 May;46(5):525-531. doi: 10.1124/dmd.117.078444. Epub 2018 Feb 14.
26. Interaction of drug metabolizing cytochrome P450 2D6 poor metabolizers with cytochrome P450 2C9 and 2C19 genotypes modify the susceptibility to head and neck cancer and treatment response. Yadav SS, etal., Mutat Res. 2010 Feb 3;684(1-2):49-55. doi: 10.1016/j.mrfmmm.2009.11.010. Epub 2009 Nov 30.
27. Structural analysis and specific expression of microsomal cytochrome P-450(M-1) mRNA in male rat livers. Yoshioka H, etal., J Biol Chem 1987 Feb 5;262(4):1706-11.
Additional References at PubMed
PMID:2455430   PMID:2894840   PMID:3164963   PMID:8068205   PMID:9618440   PMID:11562369   PMID:12477932   PMID:15129182   PMID:15340111   PMID:15489334   PMID:15591245   PMID:16401082  
PMID:17101152   PMID:17234604   PMID:17366318   PMID:18356043   PMID:18440119   PMID:18619574   PMID:18826641   PMID:18845914   PMID:18971561   PMID:19016354   PMID:19029318   PMID:19219744  
PMID:19448135   PMID:19651758   PMID:21127708   PMID:22393122   PMID:22510709   PMID:22512029   PMID:23987740   PMID:24029230   PMID:24212381   PMID:24399720   PMID:24917142   PMID:24990552  
PMID:25055826   PMID:25697375   PMID:25795462   PMID:26191268   PMID:28212823   PMID:28419964   PMID:28555194   PMID:31271766   PMID:32707261  


Genomics

Comparative Map Data
Cyp2c11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81246,175,216 - 246,211,445 (+)NCBIGRCr8
mRatBN7.21236,762,719 - 236,799,069 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1236,762,842 - 236,799,066 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1245,186,738 - 245,223,026 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01252,079,990 - 252,116,217 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01244,918,248 - 244,954,476 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01257,676,172 - 258,004,428 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1257,970,345 - 258,004,434 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01265,418,158 - 265,454,574 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41243,281,320 - 243,320,945 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1233,852,614 - 233,888,873 (+)NCBICelera
RH 3.4 Map11592.1RGD
Cytogenetic Map1q53NCBI
CYP2C18
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381094,683,729 - 94,736,190 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1094,683,729 - 94,736,190 (+)EnsemblGRCh38hg38GRCh38
GRCh371096,443,486 - 96,495,947 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361096,433,368 - 96,485,514 (+)NCBINCBI36Build 36hg18NCBI36
Build 341096,433,367 - 96,485,514NCBI
Celera1090,183,344 - 90,236,039 (+)NCBICelera
Cytogenetic Map10q23.33NCBI
HuRef1090,070,045 - 90,122,767 (+)NCBIHuRef
CHM1_11096,725,017 - 96,777,714 (+)NCBICHM1_1
T2T-CHM13v2.01095,562,854 - 95,615,317 (+)NCBIT2T-CHM13v2.0
Cyp2c52-ps
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391938,965,106 - 38,992,071 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1938,965,091 - 38,991,733 (+)EnsemblGRCm39 Ensembl
GRCm381938,976,662 - 39,003,627 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1938,976,647 - 39,003,289 (+)EnsemblGRCm38mm10GRCm38
MGSCv371939,051,152 - 39,078,117 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361939,041,818 - 39,068,332 (+)NCBIMGSCv36mm8
Celera1939,778,406 - 39,806,439 (+)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1933.61NCBI
CYP2C41
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
UNSW_CanFamBas_1.0288,733,741 - 8,753,965 (+)NCBIUNSW_CanFamBas_1.0
CYP2C9
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1988,082,124 - 88,125,390 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604848,867,040 - 48,902,540 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Cyp2c11
175 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:183
Count of miRNA genes:125
Interacting mature miRNAs:132
Transcripts:ENSRNOT00000017310
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1183970203243914901Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1183970203243914901Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1191019702246062233Rat
1358191Ept10Estrogen-induced pituitary tumorigenesis QTL 103.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)1192825253243914732Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1193113876238113876Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1196248093241248093Rat
1358292Cm37Cardiac mass QTL 376.20.00000081heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1196248093241248093Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1197670404242670404Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1197697768238755659Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1197697768242697768Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1197814409242814409Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1197814409242814409Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1197814409242814409Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1201554356246554356Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1201554356246554356Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1201554356246554356Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1201554356246554356Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1201554356246554356Rat
10059587Bw173Body weight QTL 1733.230.025body mass (VT:0001259)body weight (CMO:0000012)1202069611247069611Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1203995416244113296Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1206081677251081677Rat
1357399Bw45Body weight QTL 453.05body mass (VT:0001259)body mass index (BMI) (CMO:0000105)1206329708251329708Rat
1357404Bw42Body weight QTL 424.490.0001body mass (VT:0001259)body weight (CMO:0000012)1206329708251329708Rat
1358916Kidm22Kidney mass QTL 223.32kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1210702053240947965Rat
1358890Bp259Blood pressure QTL 2593.06arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1210702053260522016Rat
2292216Bw80Body weight QTL 803.230.0019body mass (VT:0001259)body weight (CMO:0000012)1213533809243914901Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1213707201252085212Rat
734768Niddm59Non-insulin dependent diabetes mellitus QTL 59body mass (VT:0001259)body weight (CMO:0000012)1213843987258843987Rat
61455Niddm7Non-insulin dependent diabetes mellitus QTL 75.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1214537555238757011Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1214647894259647894Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1214647894259647894Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1216255568260522016Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1216255568260522016Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1218748008257976495Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1218753689245907899Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1218753816256448513Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1221264111259647894Rat
10053715Scort24Serum corticosterone level QTL 242.130.0088blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1221414816260522016Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1222363780260522016Rat
1600392Bw123Body weight QTL 1230.001body mass (VT:0001259)body weight (CMO:0000012)1223201027260522016Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1224054293243747962Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1224054293243747962Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1224054293260122809Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1224054293260122809Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1224569538260122809Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1225126575260522016Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1228581588259647894Rat
2316896Gluco57Glucose level QTL 577.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1228985440245907899Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1232156370259647894Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233190394258625266Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1233948574260522016Rat
631690Scl5Serum cholesterol level QTL 52.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1236125214260522016Rat

Markers in Region
D1Wox47  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21236,762,334 - 236,762,551 (+)MAPPERmRatBN7.2
Rnor_6.01257,968,158 - 257,968,374NCBIRnor6.0
Rnor_6.01257,675,665 - 257,675,881NCBIRnor6.0
Rnor_5.01265,167,273 - 265,167,489UniSTSRnor5.0
Rnor_5.01265,417,651 - 265,417,867UniSTSRnor5.0
RGSC_v3.41243,280,813 - 243,281,029UniSTSRGSC3.4
Celera1233,852,107 - 233,852,323UniSTS
Cytogenetic Map1q53UniSTS
RH94623  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21236,798,866 - 236,799,047 (+)MAPPERmRatBN7.2
Rnor_6.01258,004,226 - 258,004,406NCBIRnor6.0
Rnor_5.01265,454,372 - 265,454,552UniSTSRnor5.0
RGSC_v3.41243,320,746 - 243,320,926UniSTSRGSC3.4
Celera1233,888,674 - 233,888,854UniSTS
RH 3.4 Map11592.1UniSTS
Cytogenetic Map1q53UniSTS


Genetic Models
This gene Cyp2c11 is modified in the following models/strains:


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 6 6 6
Medium 3 3 3 6
Low 3 2 5 2 1 1 1 8 1 1
Below cutoff 3 8 19 8 11 8 4 5 25 6 17 5 4

Sequence


RefSeq Acc Id: ENSRNOT00000088853   ⟹   ENSRNOP00000074503
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1236,762,842 - 236,799,066 (+)Ensembl
Rnor_6.0 Ensembl1257,970,345 - 258,004,434 (+)Ensembl
RefSeq Acc Id: NM_019184   ⟹   NP_062057
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81246,175,216 - 246,211,442 (+)NCBI
mRatBN7.21236,762,842 - 236,799,066 (+)NCBI
Rnor_6.01257,676,172 - 258,004,425 (+)NCBI
Rnor_5.01265,418,158 - 265,454,574 (+)NCBI
RGSC_v3.41243,281,320 - 243,320,945 (+)RGD
Celera1233,852,614 - 233,888,873 (+)RGD
Sequence:
RefSeq Acc Id: XM_008760364   ⟹   XP_008758586
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81246,176,284 - 246,211,445 (+)NCBI
mRatBN7.21236,764,001 - 236,799,069 (+)NCBI
Rnor_6.01257,970,344 - 258,004,428 (+)NCBI
Sequence:
RefSeq Acc Id: NP_062057   ⟸   NM_019184
- UniProtKB: Q63141 (UniProtKB/Swiss-Prot),   Q64554 (UniProtKB/Swiss-Prot),   P08683 (UniProtKB/Swiss-Prot),   A6I196 (UniProtKB/TrEMBL),   A0A0G2K879 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008758586   ⟸   XM_008760364
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K879 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074503   ⟸   ENSRNOT00000088853

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P08683-F1-model_v2 AlphaFold P08683 1-500 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2469 AgrOrtholog
BioCyc Gene G2FUF-55769 BioCyc
Ensembl Genes ENSRNOG00000052810 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055028578 UniProtKB/Swiss-Prot
  ENSRNOG00060019291 UniProtKB/Swiss-Prot
  ENSRNOG00065028890 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000088853 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000088853.2 UniProtKB/Swiss-Prot
  ENSRNOT00055049473 UniProtKB/Swiss-Prot
  ENSRNOT00060033397 UniProtKB/Swiss-Prot
  ENSRNOT00065049889 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7369647 IMAGE-MGC_LOAD
InterPro Cyt_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-I_CYP2B-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29277 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:108707 IMAGE-MGC_LOAD
NCBI Gene 29277 ENTREZGENE
PANTHER CYTOCHROME P450 2C18 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CYTOCHROME P450 508A4-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam p450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cyp2c11 PhenoGen
PRINTS EP450I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EP450ICYP2B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000052810 RatGTEx
  ENSRNOG00055028578 RatGTEx
  ENSRNOG00060019291 RatGTEx
  ENSRNOG00065028890 RatGTEx
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K879 ENTREZGENE, UniProtKB/TrEMBL
  A6I196 ENTREZGENE, UniProtKB/TrEMBL
  CP2CB_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q63141 ENTREZGENE
  Q64554 ENTREZGENE
UniProt Secondary Q63141 UniProtKB/Swiss-Prot
  Q64554 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-13 Cyp2c11  cytochrome P450, subfamily 2, polypeptide 11  Cyp2c11l  cytochrome P450, subfamily 2, polypeptide 11-like  Data merged from RGD:632285 737654 APPROVED
2015-11-13 Cyp2c11  cytochrome P450, subfamily 2, polypeptide 11  Cyp2c11  cytochrome P450, subfamily 2, polypeptide 11  Type changed (type changed from [null] to [protein-coding]) 629549 APPROVED
2015-07-29 Cyp2c11  cytochrome P450, subfamily 2, polypeptide 11  LOC100911826  cytochrome P450 2C11-like  Data merged from RGD:6490535 737654 PROVISIONAL
2012-07-05 LOC100911826  cytochrome P450 2C11-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2010-04-19 Cyp2c11l  cytochrome P450, subfamily 2, polypeptide 11-like  Cyp2c11  cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 11  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-04-19 Cyp2c11  cytochrome P450, subfamily 2, polypeptide 11  Cyp2c  cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-09-27 Cyp2j5-ps  cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase)  Cyp2c  Cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase)  Name updated 1299863 APPROVED
2005-10-12 Cyp2c11        Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Cyp2c  Cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression male-specific 70587
gene_expression strongly induced at puberty in liver 70587
gene_expression most abundant of the Cyp enzymes in non-stimulated liver 1298853
gene_expression exhibits male-specific expression in liver 1298854
gene_process metabolizes testosterone 1298853
gene_regulation stimulation by Stat5b is modulated by Hnf3b 70587
gene_regulation induced by menadione 1300400