Cyp2b1 (cytochrome P450, family 2, subfamily b, polypeptide 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Cyp2b1 (cytochrome P450, family 2, subfamily b, polypeptide 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Cyp2b1
Name: cytochrome P450, family 2, subfamily b, polypeptide 1
RGD ID: 2466
Description: Enables Hsp70 protein binding activity; Hsp90 protein binding activity; and steroid hydroxylase activity. Involved in several processes, including response to calcium ion; response to insulin; and response to sulfur dioxide. Located in mitochondrial inner membrane. Biomarker of depressive disorder and obesity. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; drug dependence (multiple); human immunodeficiency virus infectious disease; neonatal abstinence syndrome; and nicotine dependence. Orthologous to human CYP2B6 (cytochrome P450 family 2 subfamily B member 6); PARTICIPATES IN arachidonic acid metabolic pathway; phase I biotransformation pathway via cytochrome P450; retinol metabolic pathway; INTERACTS WITH (+)-alpha-Bisabolol; (+)-artemisinin; (+)-isoborneol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Cyp2b-1; Cypbe; CYPIIB1; cytochrome P450 2B1; Cytochrome P450, subfamily IIB (phenobarbital-inducible) (b, e); cytochrome P450-B; cytochrome P450-LM2; cytochrome P450-PB1; cytochrome P450-PB2; cytochrome P450b; MGC188065; P450-B; P450-LM2; P450-PB1 and P450-PB2; P450b
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Candidate Gene For: Tcas6
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8190,646,098 - 90,669,762 (+)NCBIGRCr8GRCr8GRCr8
mRatBN7.2181,518,387 - 81,544,999 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl181,518,408 - 81,542,052 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx186,938,413 - 86,962,689 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0195,437,230 - 95,461,063 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0188,694,243 - 88,718,519 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0799,142,431 - 99,183,540 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl799,142,450 - 99,181,783 (+)Ensemblrn6Rnor6.0
Rnor_5.0799,752,108 - 99,777,546 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4181,266,828 - 81,290,471 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera175,950,659 - 75,974,302 (+)NCBICelera
RGSC_v3.1181,341,201 - 81,344,952 (+)NCBI
Cytogenetic Map1q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-Bisabolol  (EXP)
(+)-artemisinin  (EXP)
(+)-isoborneol  (EXP)
(-)-cotinine  (EXP)
(R)-camphor  (EXP)
(S)-nicotine  (EXP)
1,1,1-Trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane  (EXP)
1,2,4,5-tetrachlorobenzene  (EXP)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (EXP)
1,2-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
1,4-benzoquinone  (EXP)
1,4-dichlorobenzene  (EXP)
1,4-dioxane  (EXP)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
19-Nor-17alpha-pregn-5(10)-en-20-yne-3alpha,17beta-diol  (EXP)
2,2',3,3',6,6'-hexachlorobiphenyl  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,4,3',4'-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4,4'-trichlorobiphenyl  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2-acetamidofluorene  (EXP)
2-Oxohexane  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,3'-diindolylmethane  (EXP)
3-methylbenzyl alcohol  (EXP)
3-methylcholanthrene  (EXP)
4'-tert-Butyl-2',6'-dimethyl-3',5'-dinitroacetophenone  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-methylene-bis-(2-chloroaniline)  (EXP)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-Vinylcyclohexene  (EXP)
5,5-diethylbarbituric acid  (EXP)
5,7-dihydroxy-4'-methoxyflavone  (EXP)
5-fluorouracil  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
7,12-dimethyltetraphene  (EXP)
acetone  (EXP)
acetonitrile  (EXP)
aflatoxin B1  (EXP)
alachlor  (EXP)
allyl alcohol  (EXP)
alpha-hexachlorocyclohexane  (EXP)
alpha-pinene  (EXP)
amitraz  (EXP)
amitriptyline  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
aniline  (EXP)
Aroclor 1254  (EXP)
aspartame  (EXP)
atrazine  (EXP)
barbiturates  (EXP)
benzene  (EXP)
benzo[a]pyrene  (EXP)
benzophenone  (EXP)
beta-myrcene  (EXP)
beta-naphthoflavone  (EXP)
bexarotene  (EXP)
bilobalide  (EXP)
biphenyl-4-amine  (EXP)
bisphenol A  (EXP)
bitertanol  (EXP)
bromodichloromethane  (EXP)
bromuconazole  (EXP)
brucine  (EXP)
bupropion  (EXP)
Butylbenzyl phthalate  (EXP)
Butylparaben  (EXP)
C.I. Natural Red 20  (EXP)
camphor  (EXP)
carbamazepine  (EXP)
carbon monoxide  (EXP)
chloral hydrate  (EXP)
chlordecone  (EXP)
chlorobenzene  (EXP)
chlorpyrifos  (EXP)
chlorzoxazone  (EXP)
choline  (EXP)
ciprofibrate  (EXP)
citral  (EXP)
citronellal  (EXP)
climbazole  (EXP)
clofibrate  (EXP)
clofibric acid  (EXP)
clonazepam  (EXP)
clotrimazole  (EXP)
corticosterone  (EXP)
cortisol  (EXP)
cumene hydroperoxide  (EXP)
curcumin  (EXP)
cyclophosphamide  (EXP)
cyhalothrin  (EXP)
cypermethrin  (EXP)
cyproconazole  (EXP)
DDD  (EXP)
DDE  (EXP)
DDT  (EXP)
decabromodiphenyl ether  (EXP)
deoxycholic acid  (EXP)
dexamethasone  (EXP)
dextran sulfate  (EXP)
Diallyl sulfide  (EXP)
diallyl trisulfide  (EXP)
diazepam  (EXP)
dibutyl phthalate  (EXP)
dicofol  (EXP)
Dicyclohexyl phthalate  (EXP)
diethyl phthalate  (EXP)
diethyldithiocarbamic acid  (EXP)
diethylstilbestrol  (EXP)
Dimethyl phthalate  (EXP)
dimethyl sulfoxide  (EXP)
dimethylarsinic acid  (EXP)
dioxygen  (EXP)
dipropyl phthalate  (EXP)
disulfiram  (EXP)
endosulfan  (EXP)
epoxiconazole  (EXP)
ethanol  (EXP)
ethylbenzene  (EXP)
ethylparaben  (EXP)
farnesol  (EXP)
fenofibrate  (EXP)
fenvalerate  (EXP)
fipronil  (EXP)
fluoren-9-one  (EXP)
fluorene  (EXP)
gadolinium trichloride  (EXP)
gamma-hexachlorocyclohexane  (EXP)
gamma-terpinene  (EXP)
gentamycin  (EXP)
geranial  (EXP)
glafenine  (EXP)
GW 7647  (EXP)
hemin  (EXP)
hexachlorobenzene  (EXP)
hexane  (EXP)
hydrogen peroxide  (EXP)
hydroquinone  (EXP)
Hydroxybupropion  (EXP)
ifosfamide  (EXP)
indole-3-methanol  (EXP)
Isosafrole  (EXP)
ketamine  (EXP)
ketoconazole  (EXP)
L-methionine  (EXP)
lansoprazole  (EXP)
limonene  (EXP)
linuron  (EXP)
m-tolualdehyde  (EXP)
m-xylene  (EXP)
mangiferin  (EXP)
metazachlor  (EXP)
methoxsalen  (EXP)
methoxychlor  (EXP)
methylarsonic acid  (EXP)
metolachlor  (EXP)
metyrapone  (EXP)
mifepristone  (EXP)
mirex  (EXP)
mitomycin C  (EXP)
monobenzyl phthalate  (EXP)
Monobutylphthalate  (EXP)
musk xylene  (EXP)
N'-(2,4-dimethylphenyl)-N-methylformamidine  (EXP)
N,N-diethyl-m-toluamide  (EXP)
N-acetyl-L-cysteine  (EXP)
N-Nitrosodi-n-butylamine  (EXP)
N-Nitrosodi-n-propylamine  (EXP)
N-nitrosodiethylamine  (EXP)
N-Vinyl-2-pyrrolidone  (EXP)
NADP zwitterion  (EXP)
NADP(+)  (EXP)
nevirapine  (EXP)
nicotine  (EXP)
o-xylene  (EXP)
octamethylcyclotetrasiloxane  (EXP)
okadaic acid  (EXP)
oltipraz  (EXP)
omeprazole  (EXP)
oxazepam  (EXP)
p-xylene  (EXP)
pantoprazole  (EXP)
paracetamol  (EXP)
paraquat  (EXP)
parathion  (EXP)
parathion-methyl  (EXP)
PCB138  (EXP)
pentachlorobenzene  (EXP)
pentane-2,3-dione  (EXP)
pentobarbital  (EXP)
perfluorohexanesulfonic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
permethrin  (EXP)
phenethyl caffeate  (EXP)
phenformin  (EXP)
phenobarbital  (EXP)
phenol  (EXP)
phenytoin  (EXP)
phorone  (EXP)
phoxim  (EXP)
pioglitazone  (EXP)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
prochloraz  (EXP)
propachlor  (EXP)
propiconazole  (EXP)
propylbenzene  (EXP)
propylparaben  (EXP)
propyzamide  (EXP)
pyrazinecarboxamide  (EXP)
pyrene  (EXP)
pyrethrins  (EXP)
pyridine  (EXP)
reactive oxygen species  (EXP)
resveratrol  (EXP)
Retrorsine  (EXP)
rotenone  (EXP)
sanguinarine  (EXP)
Shikonin  (EXP)
sodium arsenite  (EXP)
sodium chromate  (EXP)
sodium dichromate  (EXP)
stilbene oxide  (EXP)
streptozocin  (EXP)
strychnine  (EXP)
styrene  (EXP)
styrene oxide  (EXP)
Sudan III  (EXP)
sulfoxaflor  (EXP)
tacrine  (EXP)
tebuconazole  (EXP)
tert-butyl ethyl ether  (EXP)
testosterone  (EXP)
tetrachloroethene  (EXP)
tetrachloromethane  (EXP)
Tetramethylthiourea  (EXP)
thiabendazole  (EXP)
thiophanate-methyl  (EXP)
Thiotepa  (EXP)
toluene  (EXP)
toluene 2,4-diisocyanate  (EXP)
trans-1,2-dichloroethene  (EXP)
triadimefon  (EXP)
trichloroethene  (EXP)
triclosan  (EXP)
trimethylarsine oxide  (EXP)
triphenyl phosphate  (EXP)
Triptolide  (EXP)
troglitazone  (EXP)
uranium atom  (EXP)
ursodeoxycholic acid  (EXP)
valdecoxib  (EXP)
vinclozolin  (EXP)
zinc protoporphyrin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Hydroxylation of fatty acids by microsomal and reconstituted cytochrome P450 2B1. Alterman MA and Hanzlik RP, FEBS Lett 2002 Feb 13;512(1-3):319-22.
2. Mitochondrial targeting of cytochrome P450 proteins containing NH2-terminal chimeric signals involves an unusual TOM20/TOM22 bypass mechanism. Anandatheerthavarada HK, etal., J Biol Chem. 2009 Jun 19;284(25):17352-63. doi: 10.1074/jbc.M109.007492. Epub 2009 Apr 28.
3. Expression of cytochrome CYP2B1/2 in nonpregnant, pregnant and fetal rats exposed to tobacco smoke. Czekaj P, etal., Acta Biochim Pol 2000;47(4):1115-27.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Hemin-mediated restoration of allylisopropylacetamide-inactivated CYP2B1: a role for glutathione and GRP94 in the heme-protein assembly. Gavrilovich Zgoda V, etal., Arch Biochem Biophys 2002 Dec 1;408(1):58-68.
6. Differential expression of cytochrome P450 enzymes in cultured and intact foetal rat ventral mesencephalon. Gilbert EA, etal., J Neural Transm 2003 Oct;110(10):1091-101.
7. Molecular basis for the differences in lidocaine binding and regioselectivity of oxidation by cytochromes P450 2B1 and 2B2. Hanna IH, etal., Biochemistry. 1998 Jan 6;37(1):311-8.
8. Gadolinium chloride suppresses styrene-induced cytochrome P450s expression in rat liver. Hirasawa F, etal., Biomed Res. 2008 Dec;28(6):323-30.
9. Escherichia coli expression and characterization of cytochromes P450 2B11, 2B1, and 2B5. John GH, etal., Arch Biochem Biophys. 1994 Nov 1;314(2):367-75.
10. Effects of choline-deprivation on paracetamol- or phenobarbital-induced rat liver metabolic response. Konstandi M, etal., J Appl Toxicol. 2008 Sep 16.
11. Hepatic drug metabolizing profile of Flinders Sensitive Line rat model of depression. Kotsovolou O, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2010 Aug 16;34(6):1075-84. Epub 2010 Jun 4.
12. Suppression of hepatic cytochrome p450-mediated drug metabolism during the late stage of sepsis in rats. Lee SH and Lee SM, Shock. 2005 Feb;23(2):144-9.
13. Ciprofibrate, clofibric acid and respective glycinate derivatives. Effects of a four-week treatment on male lean and obese Zucker rats. Lupp A, etal., Arzneimittelforschung. 2008;58(5):225-41.
14. Blood coagulation-related parameter changes in Sprague-Dawley (SD) rats treated with phenobarbital (PB) and PB plus vitamin K. Mochizuki M, etal., J Toxicol Sci. 2008 Aug;33(3):307-14.
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. Use of a quantitative real-time reverse transcription-polymerase chain reaction method to study the induction of CYP1A, CYP2B and CYP4A forms in precision-cut rat liver slices. Pan J, etal., Xenobiotica 2002 Sep;32(9):739-47.
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. Wei sheng yan jiu = Journal of hygiene research Qin GH and Meng ZQ, Wei Sheng Yan Jiu. 2006 Sep;35(5):554-6.
19. GOA pipeline RGD automated data pipeline
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Phenobarbitone-mediated translocation of the cytosolic proteins interacting with the 5'-proximal region of rat liver CYP2B1/B2 gene into the nucleus. Samudre KR, etal., Biochem Biophys Res Commun 2002 Mar 29;292(2):312-7.
22. Sequence of the rat PB-inducible CYP2B1 promoter. Shaw PM, etal., Biochim Biophys Acta 1996 Feb 7;1305(1-2):54-8.
23. Differential regulation of hepatic cytochrome P450 monooxygenases in streptozotocin-induced diabetic rats. Sindhu RK, etal., Free Radic Res. 2006 Sep;40(9):921-8.
24. Effect of calcium channel antagonists nifedipine and nicardipine on rat cytochrome P-450 2B and 3A forms. Zangar RC, etal., J Pharmacol Exp Ther. 1999 Sep;290(3):1436-41.
25. Cooperation of the inducible nitric oxide synthase and cytochrome P450 1A1 in mediating lung inflammation and mutagenicity induced by diesel exhaust particles. Zhao H, etal., Environ Health Perspect. 2006 Aug;114(8):1253-8.
Additional References at PubMed
PMID:109438   PMID:2539047   PMID:2583091   PMID:2989270   PMID:3838174   PMID:3928374   PMID:6300027   PMID:6306654   PMID:6953431   PMID:8142377   PMID:12164868   PMID:12477932  
PMID:14722249   PMID:15572372   PMID:15774478   PMID:15813386   PMID:16418063   PMID:17560764   PMID:17646928   PMID:17697118   PMID:19702544   PMID:20166883   PMID:20407477   PMID:20947506  
PMID:21467745   PMID:22612225   PMID:22905390   PMID:23012479   PMID:24368200   PMID:24727239   PMID:25036135   PMID:25052003   PMID:26913515   PMID:28532222   PMID:31049204  


Genomics

Variants

.
Variants in Cyp2b1
139 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:44
Count of miRNA genes:43
Interacting mature miRNAs:43
Transcripts:ENSRNOT00000044127
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15389511782174945Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)17219768090508767Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14936146582174945Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)15034351099980958Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)15389511782174945Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)17843075491209302Rat

Markers in Region
D1Hmgc4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2181,518,043 - 81,518,167 (+)MAPPERmRatBN7.2
mRatBN7.2181,594,162 - 81,594,314 (+)MAPPERmRatBN7.2
Rnor_6.0183,103,516 - 83,103,667NCBIRnor6.0
Rnor_6.0799,142,086 - 99,142,209NCBIRnor6.0
Rnor_5.0184,360,827 - 84,360,978UniSTSRnor5.0
Rnor_5.0799,736,092 - 99,736,215UniSTSRnor5.0
RGSC_v3.4181,345,016 - 81,345,167UniSTSRGSC3.4
RGSC_v3.4181,342,475 - 81,345,421RGDRGSC3.4
RGSC_v3.4181,266,464 - 81,266,587UniSTSRGSC3.4
Celera176,026,306 - 76,026,457UniSTS
Celera175,950,295 - 75,950,418UniSTS
RH 3.4 Map1827.8UniSTS
RH 3.4 Map1827.8RGD
Cytogenetic Map1q21UniSTS
D1Wox48  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2181,594,189 - 81,594,416 (+)MAPPERmRatBN7.2
mRatBN7.2181,518,070 - 81,518,269 (+)MAPPERmRatBN7.2
Rnor_6.0799,142,113 - 99,142,311NCBIRnor6.0
Rnor_6.0183,103,543 - 83,103,769NCBIRnor6.0
Rnor_5.0799,736,119 - 99,736,317UniSTSRnor5.0
Rnor_5.0184,360,854 - 84,361,080UniSTSRnor5.0
RGSC_v3.4181,266,491 - 81,266,689UniSTSRGSC3.4
RGSC_v3.4181,345,043 - 81,345,269UniSTSRGSC3.4
Celera176,026,333 - 76,026,559UniSTS
Celera175,950,322 - 75,950,520UniSTS
Cytogenetic Map1q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
12 9 25 38 84 83 53 25 53 6 173 71 18 29 62 30

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001134844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008765491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008765492 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008765493 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AH002161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ320166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC166502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J00719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M26854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M26855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M37134 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U30327 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000047540   ⟹   ENSRNOP00000045196
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl181,518,408 - 81,542,052 (+)Ensembl
RefSeq Acc Id: NM_001134844   ⟹   NP_001128316
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8190,646,119 - 90,669,762 (+)NCBI
mRatBN7.2181,518,408 - 81,542,053 (+)NCBI
Rnor_6.0799,158,102 - 99,181,774 (+)NCBI
Rnor_5.0799,752,108 - 99,777,546 (+)NCBI
RGSC_v3.4181,266,828 - 81,290,471 (+)RGD
Celera175,950,659 - 75,974,302 (+)RGD
Sequence:
RefSeq Acc Id: XM_039095056   ⟹   XP_038950984
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8190,646,098 - 90,669,762 (+)NCBI
mRatBN7.2181,518,387 - 81,544,999 (+)NCBI
RefSeq Acc Id: NP_001128316   ⟸   NM_001134844
- Peptide Label: precursor
- UniProtKB: Q64584 (UniProtKB/Swiss-Prot),   P00176 (UniProtKB/Swiss-Prot),   B2GV28 (UniProtKB/TrEMBL),   F1MAD8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038950984   ⟸   XM_039095056
- Peptide Label: isoform X1
- UniProtKB: Q64584 (UniProtKB/Swiss-Prot),   P00176 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000045196   ⟸   ENSRNOT00000047540

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P00176-F1-model_v2 AlphaFold P00176 1-491 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2466 AgrOrtholog
BioCyc Gene G2FUF-60348 BioCyc
Ensembl Genes ENSRNOG00000033680 Ensembl
  ENSRNOG00000063855 Ensembl
  ENSRNOG00000073837 ENTREZGENE
Ensembl Transcript ENSRNOT00000083650 ENTREZGENE
  ENSRNOT00000139991 ENTREZGENE
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot
InterPro Cyt_P450 UniProtKB/Swiss-Prot
  Cyt_P450_CS UniProtKB/Swiss-Prot
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot
  Cyt_P450_E_grp-I_CYP2B-like UniProtKB/Swiss-Prot
  Cyt_P450_sf UniProtKB/Swiss-Prot
  Cytochrome_P450_fam2 UniProtKB/Swiss-Prot
NCBI Gene 24300 ENTREZGENE
PANTHER CYTOCHROME P450 2B6 UniProtKB/Swiss-Prot
  CYTOCHROME P450 508A4-RELATED UniProtKB/Swiss-Prot
Pfam p450 UniProtKB/Swiss-Prot
PhenoGen Cyp2b1 PhenoGen
PRINTS EP450I UniProtKB/Swiss-Prot
  EP450ICYP2B UniProtKB/Swiss-Prot
  P450 UniProtKB/Swiss-Prot
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000033680 RatGTEx
  ENSRNOG00000063855 RatGTEx
  ENSRNOG00000073837 RatGTEx
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot
UniProt B2GV28 ENTREZGENE, UniProtKB/TrEMBL
  CP2B1_RAT UniProtKB/Swiss-Prot
  F1MAD8 ENTREZGENE
  F7FBM8_RAT UniProtKB/TrEMBL
  P00176 ENTREZGENE
  Q64584 ENTREZGENE
UniProt Secondary Q64584 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2007-09-27 Cyp2j5-ps  cytochrome P450, family 2, subfamily b, polypeptide 1  Cyp2b1  Cytochrome P450, family 2, subfamily b, polypeptide 1  Name updated 1299863 PROVISIONAL
2006-02-09 Cyp2b1  Cytochrome P450, family 2, subfamily b, polypeptide 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-05-03   Cytochrome P450, family 2, subfamily b, polypeptide 1  Cyp2b1  Cytochrome P450, subfamily IIB (phenobarbital-inducible) (b, e)  Name updated 1299863 APPROVED
2002-06-10 Cyp2b1  Cytochrome P450, subfamily IIB (phenobarbital-inducible) (b, e)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed after exposure to nicotine in liver and lung by time- and tissue-specific mechanisms 1298848
gene_function participates in hydoxylation of decanoic acid and other fatty acids 1298849
gene_process metabolizes nicotine and activates carcinogens 1298848
gene_regulation interaction with the positive response element is essential for the PB-mediated translocation of cytosolic protein complexes into the nucleus 625556
gene_regulation transcription is phenobarbitol- and Aroclor 1254- (ARO) inducible 1298850
gene_regulation promoter region contains recognition sites for HNF3, AP-1, NF-kappa B and various STAT proteins (+27 to -3878) 1298850
gene_transcript promoter region contains both positive (-69 to -98 bp) and negative response elements for phenobarbitone (PB) 625556