Cyp2a1 Rat (+)-schisandrin B multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2A1 mRNA] CTD PMID:31150632 Cyp2a1 Rat (1->4)-beta-D-glucan multiple interactions ISO Cyp2a22 (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of CYP2A22 mRNA CTD PMID:36331819 Cyp2a1 Rat (S)-nicotine increases expression EXP 6480464 Nicotine results in increased expression of CYP2A1 mRNA CTD PMID:22934830 Cyp2a1 Rat (S)-nicotine multiple interactions ISO CYP2A13 (Homo sapiens) 6480464 Nicotine inhibits the reaction [[CYP2A13 protein results in increased metabolism of N'-nitrosonornicotine] which results in increased abundance of 4-hydroxy-1-(3-pyridyl)-1-butanone] and Nicotine inhibits the reaction [CYP2A13 protein results in increased susceptibility to Aflatoxin B1] CTD PMID:22743290 and PMID:27567546 Cyp2a1 Rat (S)-nicotine decreases activity ISO CYP2A13 (Homo sapiens) 6480464 Nicotine results in decreased activity of CYP2A13 protein CTD PMID:27567546 Cyp2a1 Rat (S)-nicotine increases metabolic processing ISO CYP2A13 (Homo sapiens) 6480464 CYP2A13 protein results in increased metabolism of Nicotine CTD PMID:22743290 Cyp2a1 Rat 1,3,5-trinitro-1,3,5-triazinane increases expression EXP 6480464 cyclonite results in increased expression of CYP2A1 mRNA CTD PMID:25559034 Cyp2a1 Rat 1-benzylpiperazine decreases expression EXP 6480464 N-benzylpiperazine results in decreased expression of CYP2A1 mRNA CTD PMID:26821219 Cyp2a1 Rat 1-naphthol increases abundance ISO CYP2A13 (Homo sapiens) 6480464 CYP2A13 protein results in increased abundance of 1-naphthol CTD PMID:27137136 Cyp2a1 Rat 1-naphthol multiple interactions ISO CYP2A13 (Homo sapiens) 6480464 [CYP2A13 protein results in increased oxidation of naphthalene] which results in increased abundance of 1-naphthol CTD PMID:27137136 Cyp2a1 Rat 1-naphthyl isothiocyanate decreases expression EXP 6480464 1-Naphthylisothiocyanate results in decreased expression of CYP2A1 mRNA CTD PMID:30723492 Cyp2a1 Rat 17alpha-ethynylestradiol affects expression EXP 6480464 Ethinyl Estradiol affects the expression of CYP2A1 mRNA CTD PMID:16079270 Cyp2a1 Rat 17beta-estradiol affects expression EXP 6480464 Estradiol affects the expression of CYP2A1 mRNA CTD PMID:32145629 Cyp2a1 Rat 17beta-estradiol 3-benzoate decreases expression EXP 6480464 estradiol 3-benzoate results in decreased expression of CYP2A1 protein CTD PMID:24752506 Cyp2a1 Rat 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of CYP2A1 mRNA CTD PMID:16054898 more ... Cyp2a1 Rat 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO CYP2A13 (Homo sapiens) 6480464 [Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CYP2A13 mRNA CTD PMID:26159488 Cyp2a1 Rat 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO Cyp2a22 (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in decreased expression of CYP2A22 mRNA CTD PMID:28213091 Cyp2a1 Rat 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Cyp2a22 (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of CYP2A22 mRNA CTD PMID:26377647 and PMID:28922406 Cyp2a1 Rat 2,4-dinitrotoluene affects expression EXP 6480464 2 and 4-dinitrotoluene affects the expression of CYP2A1 mRNA CTD PMID:21346803 Cyp2a1 Rat 2-acetamidofluorene increases expression ISO Cyp2a22 (Mus musculus) 6480464 2-Acetylaminofluorene results in increased expression of CYP2A22 mRNA CTD PMID:21607683 Cyp2a1 Rat 3,3',4,4',5-pentachlorobiphenyl increases expression EXP 6480464 3 more ... CTD PMID:19692669 Cyp2a1 Rat 3-methylcholanthrene increases expression EXP 6480464 Methylcholanthrene results in increased expression of CYP2A1 mRNA CTD PMID:11323195 more ... Cyp2a1 Rat 3-methyleneindolenine multiple interactions ISO CYP2A13 (Homo sapiens) 6480464 [CYP2A13 protein results in increased metabolism of Skatole] which results in increased chemical synthesis of 3-methyleneindolenine CTD PMID:20187624 Cyp2a1 Rat 3H-1,2-dithiole-3-thione increases expression EXP 6480464 1 and 2-dithiol-3-thione results in increased expression of CYP2A1 mRNA CTD PMID:19162173 Cyp2a1 Rat 4,4'-diaminodiphenylmethane decreases expression EXP 6480464 4 and 4'-diaminodiphenylmethane results in decreased expression of CYP2A1 mRNA CTD PMID:30723492 Cyp2a1 Rat 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one affects metabolic processing ISO CYP2A13 (Homo sapiens) 6480464 CYP2A13 protein affects the metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone CTD PMID:12920169 and PMID:17717079 Cyp2a1 Rat 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one increases metabolic processing ISO CYP2A13 (Homo sapiens) 6480464 CYP2A13 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone CTD PMID:17717079 more ... Cyp2a1 Rat 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one increases hydroxylation ISO CYP2A13 (Homo sapiens) 6480464 CYP2A13 protein results in increased hydroxylation of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone and CYP2A13 results in increased hydroxylation of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone CTD PMID:17922361 and PMID:21473878 Cyp2a1 Rat 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one increases activity ISO CYP2A13 (Homo sapiens) 6480464 CYP2A13 results in increased activity of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone CTD PMID:21473878 Cyp2a1 Rat 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one decreases metabolic processing ISO CYP2A13 (Homo sapiens) 6480464 CYP2A13 protein SNP results in decreased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone CTD PMID:14633739 Cyp2a1 Rat 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one decreases hydroxylation ISO CYP2A13 (Homo sapiens) 6480464 CYP2A13 gene polymorphism results in decreased hydroxylation of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone CTD PMID:17922361 Cyp2a1 Rat 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one multiple interactions ISO CYP2A13 (Homo sapiens) 6480464 [CYP2A13 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] which results in increased abundance of 4-hydroxy-1-(3-pyridyl)-1-butanone more ... CTD PMID:14633739 more ... Cyp2a1 Rat 4-oxo-4-(pyridin-3-yl)butanal multiple interactions ISO CYP2A13 (Homo sapiens) 6480464 [CYP2A13 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] which results in increased abundance of 4-oxo-4-(3-pyridinebutanal) and [CYP2A13 protein results in increased metabolism of N'-nitrosonornicotine] which results in increased abundance of 4-oxo-4-(3-pyridinebutanal) CTD PMID:27567546 Cyp2a1 Rat 4-oxo-4-(pyridin-3-yl)butanal increases abundance ISO CYP2A13 (Homo sapiens) 6480464 CYP2A13 protein results in increased abundance of 4-oxo-4-(3-pyridinebutanal) CTD PMID:27567546 Cyp2a1 Rat 5-Hydroxyflavone increases oxidation ISO CYP2A13 (Homo sapiens) 6480464 CYP2A13 protein results in increased oxidation of 5-hydroxyflavone CTD PMID:30964977 Cyp2a1 Rat 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole affects expression EXP 6480464 Omeprazole affects the expression of CYP2A1 mRNA CTD PMID:19483382 Cyp2a1 Rat 6-propyl-2-thiouracil affects expression EXP 6480464 Propylthiouracil affects the expression of CYP2A1 mRNA CTD PMID:19483382 Cyp2a1 Rat 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of CYP2A1 mRNA CTD PMID:22504374 Cyp2a1 Rat 9-phenanthrol multiple interactions ISO CYP2A13 (Homo sapiens) 6480464 [CYP2A13 protein results in increased oxidation of phenanthrene] which results in increased abundance of 9-phenanthrol CTD PMID:27137136 Cyp2a1 Rat 9-phenanthrol increases abundance ISO CYP2A13 (Homo sapiens) 6480464 CYP2A13 protein results in increased abundance of 9-phenanthrol CTD PMID:27137136 Cyp2a1 Rat acenaphthene multiple interactions ISO CYP2A13 (Homo sapiens) 6480464 [CYP2A13 protein results in increased oxidation of acenaphthene] which results in increased chemical synthesis of acenaphthene-1-ol CTD PMID:25642975 Cyp2a1 Rat acenaphthene increases oxidation ISO CYP2A13 (Homo sapiens) 6480464 CYP2A13 protein results in increased oxidation of acenaphthene CTD PMID:25642975 Cyp2a1 Rat acenaphthylene increases oxidation ISO CYP2A13 (Homo sapiens) 6480464 CYP2A13 protein results in increased oxidation of acenaphthylene and CYP2A13 protein results in increased oxidation of acenaphthylene metabolite CTD PMID:25642975 Cyp2a1 Rat acetophenones increases metabolic processing ISO CYP2A13 (Homo sapiens) 6480464 CYP2A13 protein results in increased metabolism of Acetophenones CTD PMID:18669584 Cyp2a1 Rat acetophenones multiple interactions ISO CYP2A13 (Homo sapiens) 6480464 CYP2A13 gene polymorphism inhibits the reaction [CYP2A13 protein results in increased metabolism of Acetophenones] CTD PMID:18669584 Cyp2a1 Rat aflatoxin B1 decreases methylation ISO CYP2A13 (Homo sapiens) 6480464 Aflatoxin B1 results in decreased methylation of CYP2A13 gene CTD PMID:27153756 Cyp2a1 Rat aflatoxin B1 increases metabolic processing ISO CYP2A13 (Homo sapiens) 6480464 CYP2A13 protein results in increased metabolism of Aflatoxin B1 CTD PMID:22743290 and PMID:26084420 Cyp2a1 Rat aflatoxin B1 multiple interactions ISO CYP2A13 (Homo sapiens) 6480464 [CYP2A13 protein co-treated with Aflatoxin B1] results in decreased expression of MIR1271 mRNA more ... CTD PMID:16917071 more ... Cyp2a1 Rat aflatoxin B1 increases response to substance ISO CYP2A13 (Homo sapiens) 6480464 CYP2A13 protein results in increased susceptibility to Aflatoxin B1 CTD PMID:22743290 and PMID:26084420 Cyp2a1 Rat Aflatoxin G1 increases expression ISO CYP2A13 (Homo sapiens) 6480464 aflatoxin G1 results in increased expression of CYP2A13 protein CTD PMID:36997055 Cyp2a1 Rat Aflatoxin G1 affects response to substance ISO CYP2A13 (Homo sapiens) 6480464 CYP2A13 protein affects the susceptibility to aflatoxin G1 CTD PMID:23907605 Cyp2a1 Rat Aflatoxin G1 increases activity ISO CYP2A13 (Homo sapiens) 6480464 CYP2A13 protein results in increased activity of aflatoxin G1 CTD PMID:23907605 Cyp2a1 Rat alendronic acid affects expression EXP 6480464 Alendronate affects the expression of CYP2A1 mRNA CTD PMID:16079270 Cyp2a1 Rat all-trans-retinoic acid increases expression ISO CYP2A13 (Homo sapiens) 6480464 Tretinoin results in increased expression of CYP2A13 mRNA CTD PMID:21376804 Cyp2a1 Rat alpha-hexachlorocyclohexane multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased activity of CYP2A1 protein CTD PMID:16246485 Cyp2a1 Rat amiodarone affects expression EXP 6480464 Amiodarone affects the expression of CYP2A1 mRNA CTD PMID:18355885 and PMID:19483382 Cyp2a1 Rat amiodarone increases expression EXP 6480464 Amiodarone results in increased expression of CYP2A1 mRNA CTD PMID:32084307 Cyp2a1 Rat amitriptyline affects expression EXP 6480464 Amitriptyline affects the expression of CYP2A1 mRNA CTD PMID:18355885 Cyp2a1 Rat ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of CYP2A1 mRNA CTD PMID:16483693 Cyp2a1 Rat amodiaquine increases metabolic processing ISO CYP2A13 (Homo sapiens) 6480464 CYP2A13 protein results in increased metabolism of Amodiaquine CTD PMID:31629065 Cyp2a1 Rat amodiaquine multiple interactions ISO CYP2A13 (Homo sapiens) 6480464 [CYP2A13 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine CTD PMID:31629065 Cyp2a1 Rat Aroclor 1254 decreases expression EXP 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of CYP2A1 mRNA CTD PMID:8471063 Cyp2a1 Rat Aroclor 1254 increases expression EXP 6480464 Chlorodiphenyl (54% Chlorine) results in increased expression of CYP2A1 mRNA and Chlorodiphenyl (54% Chlorine) results in increased expression of CYP2A1 protein CTD PMID:11323195 and PMID:8471063 Cyp2a1 Rat benzbromarone affects expression EXP 6480464 Benzbromarone affects the expression of CYP2A1 mRNA CTD PMID:19483382 Cyp2a1 Rat benzene decreases expression EXP 6480464 Benzene results in decreased expression of CYP2A1 and Benzene results in decreased expression of CYP2A1 protein CTD PMID:8517779 and PMID:9010585 Cyp2a1 Rat benzene increases expression EXP 6480464 Benzene results in increased expression of CYP2A1 protein CTD PMID:8620572 Cyp2a1 Rat benzo[a]pyrene increases methylation ISO CYP2A13 (Homo sapiens) 6480464 Benzo(a)pyrene results in increased methylation of CYP2A13 3' UTR and Benzo(a)pyrene results in increased methylation of CYP2A13 promoter CTD PMID:27901495 Cyp2a1 Rat benzo[a]pyrene decreases expression ISO CYP2A13 (Homo sapiens) 6480464 Benzo(a)pyrene results in decreased expression of CYP2A13 mRNA CTD PMID:32234424 Cyp2a1 Rat beta-naphthoflavone increases expression EXP 6480464 beta-Naphthoflavone results in increased expression of CYP2A1 mRNA CTD PMID:19118567 Cyp2a1 Rat beta-naphthoflavone increases expression ISO CYP2A13 (Homo sapiens) 6480464 beta-Naphthoflavone results in increased expression of CYP2A13 mRNA CTD PMID:22258563 Cyp2a1 Rat bexarotene multiple interactions EXP 6480464 [bexarotene co-treated with Tamoxifen] results in increased expression of CYP2A1 mRNA CTD PMID:17630414 Cyp2a1 Rat biphenyl affects binding ISO CYP2A13 (Homo sapiens) 6480464 biphenyl binds to CYP2A13 protein CTD PMID:27137136 Cyp2a1 Rat biphenyl increases oxidation ISO CYP2A13 (Homo sapiens) 6480464 CYP2A13 protein results in increased oxidation of biphenyl CTD PMID:27137136 Cyp2a1 Rat biphenyl-4-amine multiple interactions ISO CYP2A13 (Homo sapiens) 6480464 CYP2A13 protein results in increased hydroxylation of and results in increased activity of 4-biphenylamine CTD PMID:16988941 Cyp2a1 Rat bis(2-ethylhexyl) phthalate multiple interactions EXP 6480464 [Diethylhexyl Phthalate co-treated with Genistein] results in decreased expression of CYP2A1 mRNA and [Genistein co-treated with Diethylhexyl Phthalate] results in increased expression of CYP2A1 mRNA CTD PMID:25031359 and PMID:36674726 Cyp2a1 Rat bis(2-ethylhexyl) phthalate multiple interactions ISO Cyp2a22 (Mus musculus) 6480464 [Streptozocin co-treated with Dietary Fats co-treated with Diethylhexyl Phthalate] results in increased expression of CYP2A22 mRNA CTD PMID:33484791 Cyp2a1 Rat bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of CYP2A1 mRNA and bisphenol A results in decreased expression of CYP2A1 protein CTD PMID:24752506 and PMID:32145629 Cyp2a1 Rat bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of CYP2A1 protein CTD PMID:32145629 Cyp2a1 Rat bisphenol A increases expression ISO Cyp2a22 (Mus musculus) 6480464 bisphenol A results in increased expression of CYP2A22 mRNA CTD PMID:30245210 Cyp2a1 Rat bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of CYP2A1 mRNA CTD PMID:30903817 Cyp2a1 Rat cadmium dichloride increases expression ISO CYP2A13 (Homo sapiens) 6480464 Cadmium Chloride results in increased expression of CYP2A13 mRNA CTD PMID:38568856 Cyp2a1 Rat carbon nanotube decreases expression ISO Cyp2a22 (Mus musculus) 6480464 Nanotubes and Carbon results in decreased expression of CYP2A22 mRNA CTD PMID:25620056 Cyp2a1 Rat carbon nanotube affects expression ISO Cyp2a22 (Mus musculus) 6480464 Nanotubes and Carbon analog affects the expression of CYP2A22 mRNA CTD PMID:25620056 Cyp2a1 Rat chenodeoxycholic acid decreases activity EXP 6480464 Chenodeoxycholic Acid results in decreased activity of CYP2A1 protein CTD PMID:8889968 Cyp2a1 Rat chlorohydrocarbon multiple interactions EXP 6480464 [Hydrocarbons and Chlorinated co-treated with Polychlorinated Biphenyls co-treated with methylmercuric chloride] results in increased expression of CYP2A1 mRNA CTD PMID:30744511 Cyp2a1 Rat cholic acid decreases activity EXP 6480464 Cholic Acid results in decreased activity of CYP2A1 protein CTD PMID:8889968 Cyp2a1 Rat chrysin increases oxidation ISO CYP2A13 (Homo sapiens) 6480464 CYP2A13 protein results in increased oxidation of chrysin CTD PMID:30964977 Cyp2a1 Rat clofibrate affects expression EXP 6480464 Clofibrate affects the expression of CYP2A1 mRNA CTD PMID:19483382 Cyp2a1 Rat clofibrate increases expression EXP 6480464 Clofibrate results in increased expression of CYP2A1 mRNA CTD PMID:11328961 Cyp2a1 Rat clomipramine affects expression EXP 6480464 Clomipramine affects the expression of CYP2A1 mRNA CTD PMID:18355885 Cyp2a1 Rat coumarin increases hydroxylation ISO CYP2A13 (Homo sapiens) 6480464 CYP2A13 protein results in increased hydroxylation of coumarin CTD PMID:17922361 Cyp2a1 Rat coumarin decreases hydroxylation ISO CYP2A13 (Homo sapiens) 6480464 CYP2A13 gene polymorphism results in decreased hydroxylation of coumarin CTD PMID:17922361 Cyp2a1 Rat cyhalothrin increases activity EXP 6480464 cyhalothrin results in increased activity of CYP2A1 protein CTD PMID:29727961 Cyp2a1 Rat cyhalothrin increases expression EXP 6480464 cyhalothrin results in increased expression of CYP2A1 mRNA CTD PMID:29727961 Cyp2a1 Rat cylindrospermopsin decreases expression ISO CYP2A13 (Homo sapiens) 6480464 cylindrospermopsin results in decreased expression of CYP2A13 mRNA CTD PMID:23726867 Cyp2a1 Rat DDT increases expression EXP 6480464 DDT results in increased expression of CYP2A1 mRNA CTD PMID:29477483 Cyp2a1 Rat deoxycholic acid decreases activity EXP 6480464 Deoxycholic Acid results in decreased activity of CYP2A1 protein CTD PMID:8889968 Cyp2a1 Rat dexamethasone affects expression EXP 6480464 Dexamethasone affects the expression of CYP2A1 mRNA CTD PMID:15102944 Cyp2a1 Rat dichloroacetic acid increases expression ISO Cyp2a22 (Mus musculus) 6480464 Dichloroacetic Acid results in increased expression of CYP2A22 mRNA CTD PMID:28962523 Cyp2a1 Rat endosulfan multiple interactions ISO CYP2A13 (Homo sapiens) 6480464 [Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CYP2A13 mRNA CTD PMID:26159488 Cyp2a1 Rat ethanol increases expression EXP 6480464 Ethanol results in increased expression of CYP2A1 mRNA CTD PMID:15353170 Cyp2a1 Rat farnesol increases activity EXP 6480464 Farnesol results in increased activity of CYP2A1 protein CTD PMID:15840382 Cyp2a1 Rat fipronil increases expression EXP 6480464 fipronil results in increased expression of CYP2A1 mRNA CTD PMID:23962444 Cyp2a1 Rat flavonoids decreases expression EXP 6480464 Flavonoids results in decreased expression of CYP2A1 mRNA CTD PMID:18035473 Cyp2a1 Rat flutamide increases expression EXP 6480464 Flutamide results in increased expression of CYP2A1 mRNA CTD PMID:24136188 Cyp2a1 Rat Furafylline decreases activity EXP 6480464 furafylline results in decreased activity of CYP2A1 protein CTD PMID:15879494 Cyp2a1 Rat gamma-hexachlorocyclohexane increases activity EXP 6480464 Hexachlorocyclohexane results in increased activity of CYP2A1 protein CTD PMID:3569844 Cyp2a1 Rat genistein multiple interactions EXP 6480464 [Diethylhexyl Phthalate co-treated with Genistein] results in decreased expression of CYP2A1 mRNA and [Genistein co-treated with Diethylhexyl Phthalate] results in increased expression of CYP2A1 mRNA CTD PMID:25031359 and PMID:36674726 Cyp2a1 Rat glafenine decreases expression EXP 6480464 Glafenine results in decreased expression of CYP2A1 mRNA CTD PMID:24136188 Cyp2a1 Rat helenalin increases oxidation ISO CYP2A13 (Homo sapiens) 6480464 CYP2A13 protein results in increased oxidation of helenalin CTD PMID:34989853 Cyp2a1 Rat helenalin decreases activity ISO CYP2A13 (Homo sapiens) 6480464 helenalin results in decreased activity of CYP2A13 protein CTD PMID:34989853 Cyp2a1 Rat hexamethylphosphoric triamide increases metabolic processing ISO CYP2A13 (Homo sapiens) 6480464 CYP2A13 protein results in increased metabolism of Hempa CTD PMID:18669584 Cyp2a1 Rat hexamethylphosphoric triamide multiple interactions ISO CYP2A13 (Homo sapiens) 6480464 CYP2A13 gene polymorphism inhibits the reaction [CYP2A13 protein results in increased metabolism of Hempa] CTD PMID:18669584 Cyp2a1 Rat imipramine affects expression EXP 6480464 Imipramine affects the expression of CYP2A1 mRNA CTD PMID:18355885 Cyp2a1 Rat inulin multiple interactions ISO Cyp2a22 (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of CYP2A22 mRNA CTD PMID:36331819 Cyp2a1 Rat ketoconazole affects expression EXP 6480464 Ketoconazole affects the expression of CYP2A1 mRNA CTD PMID:18355885 Cyp2a1 Rat ketoconazole decreases activity EXP 6480464 Ketoconazole results in decreased activity of CYP2A1 protein CTD PMID:15879494 Cyp2a1 Rat ketoconazole increases expression EXP 6480464 Ketoconazole results in increased expression of CYP2A1 protein CTD PMID:7986207 Cyp2a1 Rat L-ethionine affects expression EXP 6480464 Ethionine affects the expression of CYP2A1 mRNA CTD PMID:19483382 Cyp2a1 Rat leflunomide increases expression EXP 6480464 leflunomide results in increased expression of CYP2A1 mRNA CTD PMID:24136188 Cyp2a1 Rat lipopolysaccharide decreases expression ISO CYP2A13 (Homo sapiens) 6480464 Lipopolysaccharides results in decreased expression of CYP2A13 mRNA and Lipopolysaccharides results in decreased expression of CYP2A13 protein CTD PMID:23884085 Cyp2a1 Rat lipopolysaccharide multiple interactions ISO CYP2A13 (Homo sapiens) 6480464 pyrrolidine dithiocarbamic acid inhibits the reaction [Lipopolysaccharides results in decreased expression of CYP2A13 mRNA] CTD PMID:23884085 Cyp2a1 Rat lithocholic acid decreases activity EXP 6480464 Lithocholic Acid results in decreased activity of CYP2A1 protein CTD PMID:8889968 Cyp2a1 Rat m-xylene affects activity EXP 6480464 3-xylene affects the activity of CYP2A1 protein CTD PMID:15204773 Cyp2a1 Rat methimazole increases expression EXP 6480464 Methimazole results in increased expression of CYP2A1 mRNA CTD PMID:22504374 Cyp2a1 Rat methoxsalen decreases activity EXP 6480464 Methoxsalen results in decreased activity of CYP2A1 protein CTD PMID:12814958 Cyp2a1 Rat methoxsalen multiple interactions ISO CYP2A13 (Homo sapiens) 6480464 [Methoxsalen results in decreased activity of CYP2A13 protein] which results in decreased susceptibility to Skatole more ... CTD PMID:17671098 more ... Cyp2a1 Rat methylisothiazolinone decreases expression ISO CYP2A13 (Homo sapiens) 6480464 2-methyl-4-isothiazolin-3-one results in decreased expression of CYP2A13 mRNA CTD PMID:31629900 Cyp2a1 Rat methylmercury chloride multiple interactions EXP 6480464 [Hydrocarbons and Chlorinated co-treated with Polychlorinated Biphenyls co-treated with methylmercuric chloride] results in increased expression of CYP2A1 mRNA CTD PMID:30744511 Cyp2a1 Rat metyrapone multiple interactions ISO CYP2A13 (Homo sapiens) 6480464 Metyrapone inhibits the reaction [CYP2A13 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] CTD PMID:18669584 Cyp2a1 Rat miconazole multiple interactions ISO CYP2A13 (Homo sapiens) 6480464 Miconazole inhibits the reaction [CYP2A13 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] CTD PMID:18669584 Cyp2a1 Rat monosodium L-glutamate multiple interactions EXP 6480464 Sodium Glutamate results in increased expression of and results in increased activity of CYP2A1 protein CTD PMID:7476908 Cyp2a1 Rat N'-Nitrosoanabasine multiple interactions ISO CYP2A13 (Homo sapiens) 6480464 N'-nitrosoanabasine inhibits the reaction [[CYP2A13 protein results in increased metabolism of N'-nitrosonornicotine] which results in increased abundance of 4-hydroxy-1-(3-pyridyl)-1-butanone] CTD PMID:27567546 Cyp2a1 Rat N'-Nitrosoanabasine decreases activity ISO CYP2A13 (Homo sapiens) 6480464 N'-nitrosoanabasine results in decreased activity of CYP2A13 protein CTD PMID:27567546 Cyp2a1 Rat N'-Nitrosoanatabine multiple interactions ISO CYP2A13 (Homo sapiens) 6480464 N'-nitrosoanatabine inhibits the reaction [[CYP2A13 protein results in increased metabolism of N'-nitrosonornicotine] which results in increased abundance of 4-hydroxy-1-(3-pyridyl)-1-butanone] CTD PMID:27567546 Cyp2a1 Rat N'-Nitrosoanatabine decreases activity ISO CYP2A13 (Homo sapiens) 6480464 N'-nitrosoanatabine results in decreased activity of CYP2A13 protein CTD PMID:27567546 Cyp2a1 Rat N'-Nitrosonornicotine increases hydroxylation ISO CYP2A13 (Homo sapiens) 6480464 CYP2A13 protein results in increased hydroxylation of N'-nitrosonornicotine CTD PMID:17922361 Cyp2a1 Rat N'-Nitrosonornicotine multiple interactions ISO CYP2A13 (Homo sapiens) 6480464 [CYP2A13 protein results in increased metabolism of N'-nitrosonornicotine] which results in increased abundance of 4-hydroxy-1-(3-pyridyl)-1-butanone more ... CTD PMID:27567546 Cyp2a1 Rat N'-Nitrosonornicotine increases metabolic processing ISO CYP2A13 (Homo sapiens) 6480464 CYP2A13 protein results in increased metabolism of N'-nitrosonornicotine CTD PMID:27567546 Cyp2a1 Rat N,N-diethyl-m-toluamide increases expression ISO CYP2A13 (Homo sapiens) 6480464 DEET results in increased expression of CYP2A13 mRNA CTD PMID:27091632 Cyp2a1 Rat N,N-dimethylaniline increases metabolic processing ISO CYP2A13 (Homo sapiens) 6480464 CYP2A13 protein results in increased metabolism of N and N-dimethylaniline CTD PMID:18669584 Cyp2a1 Rat N,N-dimethylaniline multiple interactions ISO CYP2A13 (Homo sapiens) 6480464 CYP2A13 gene polymorphism inhibits the reaction [CYP2A13 protein results in increased metabolism of N and N-dimethylaniline] CTD PMID:18669584 Cyp2a1 Rat N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased activity of CYP2A1 protein CTD PMID:16246485 Cyp2a1 Rat N-nitrosodiethylamine increases expression ISO Cyp2a22 (Mus musculus) 6480464 Diethylnitrosamine results in increased expression of CYP2A22 mRNA CTD PMID:21607683 Cyp2a1 Rat N-Nitrosoguvacoline increases activity ISO CYP2A13 (Homo sapiens) 6480464 CYP2A13 protein results in increased activity of N-nitrosoguvacoline CTD PMID:15725615 Cyp2a1 Rat N-Nitrosopyrrolidine decreases expression ISO CYP2A13 (Homo sapiens) 6480464 N-Nitrosopyrrolidine results in decreased expression of CYP2A13 mRNA CTD PMID:32234424 Cyp2a1 Rat NADP zwitterion multiple interactions ISO CYP2A13 (Homo sapiens) 6480464 [NADP co-treated with CYP2A13 protein] results in increased oxidation of 2-ethynylnaphthalene more ... CTD PMID:27137136 Cyp2a1 Rat NADP(+) multiple interactions ISO CYP2A13 (Homo sapiens) 6480464 [NADP co-treated with CYP2A13 protein] results in increased oxidation of 2-ethynylnaphthalene more ... CTD PMID:27137136 Cyp2a1 Rat naphthalene increases metabolic processing ISO CYP2A13 (Homo sapiens) 6480464 CYP2A13 protein results in increased metabolism of naphthalene CTD PMID:28599267 Cyp2a1 Rat naphthalene affects binding ISO CYP2A13 (Homo sapiens) 6480464 naphthalene binds to CYP2A13 protein CTD PMID:27137136 Cyp2a1 Rat naphthalene multiple interactions ISO CYP2A13 (Homo sapiens) 6480464 [CYP2A13 protein results in increased oxidation of naphthalene] which results in increased abundance of 1-naphthol more ... CTD PMID:27137136 and PMID:28599267 Cyp2a1 Rat naphthalene increases oxidation ISO CYP2A13 (Homo sapiens) 6480464 CYP2A13 protein results in increased oxidation of naphthalene CTD PMID:27137136 Cyp2a1 Rat nicotine increases expression EXP 6480464 Nicotine results in increased expression of CYP2A1 mRNA CTD PMID:22934830 Cyp2a1 Rat nicotine multiple interactions ISO CYP2A13 (Homo sapiens) 6480464 Nicotine inhibits the reaction [[CYP2A13 protein results in increased metabolism of N'-nitrosonornicotine] which results in increased abundance of 4-hydroxy-1-(3-pyridyl)-1-butanone] and Nicotine inhibits the reaction [CYP2A13 protein results in increased susceptibility to Aflatoxin B1] CTD PMID:22743290 and PMID:27567546 Cyp2a1 Rat nicotine increases metabolic processing ISO CYP2A13 (Homo sapiens) 6480464 CYP2A13 protein results in increased metabolism of Nicotine CTD PMID:22743290 Cyp2a1 Rat nicotine decreases activity ISO CYP2A13 (Homo sapiens) 6480464 Nicotine results in decreased activity of CYP2A13 protein CTD PMID:27567546 Cyp2a1 Rat nimesulide decreases expression EXP 6480464 nimesulide results in decreased expression of CYP2A1 mRNA CTD PMID:24136188 Cyp2a1 Rat O-methyleugenol decreases expression ISO CYP2A13 (Homo sapiens) 6480464 methyleugenol results in decreased expression of CYP2A13 mRNA CTD PMID:32234424 Cyp2a1 Rat omeprazole affects expression EXP 6480464 Omeprazole affects the expression of CYP2A1 mRNA CTD PMID:19483382 Cyp2a1 Rat organoselenium compound multiple interactions ISO CYP2A13 (Homo sapiens) 6480464 Organoselenium Compounds binds to and results in decreased activity of CYP2A13 protein CTD PMID:21732699 Cyp2a1 Rat oxycodone increases expression EXP 6480464 Oxycodone results in increased expression of CYP2A1 mRNA CTD PMID:23439660 Cyp2a1 Rat perfluorooctane-1-sulfonic acid multiple interactions ISO Cyp2a22 (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of CYP2A22 mRNA more ... CTD PMID:36331819 Cyp2a1 Rat phenanthrene increases oxidation ISO CYP2A13 (Homo sapiens) 6480464 CYP2A13 protein results in increased oxidation of phenanthrene CTD PMID:27137136 Cyp2a1 Rat phenanthrene affects binding ISO CYP2A13 (Homo sapiens) 6480464 phenanthrene binds to CYP2A13 protein CTD PMID:27137136 Cyp2a1 Rat phenanthrene multiple interactions ISO CYP2A13 (Homo sapiens) 6480464 [CYP2A13 protein results in increased oxidation of phenanthrene] which results in increased abundance of 9-phenanthrol CTD PMID:27137136 Cyp2a1 Rat phenanthrenes affects binding ISO CYP2A13 (Homo sapiens) 6480464 Phenanthrenes analog binds to CYP2A13 protein CTD PMID:27137136 Cyp2a1 Rat phenanthrenes multiple interactions ISO CYP2A13 (Homo sapiens) 6480464 [NADP co-treated with CYP2A13 protein] results in increased oxidation of Phenanthrenes analog CTD PMID:27137136 Cyp2a1 Rat phenobarbital increases expression EXP 6480464 Phenobarbital results in increased expression of CYP2A1 mRNA CTD PMID:15596064 Cyp2a1 Rat phenobarbital decreases expression ISO Cyp2a22 (Mus musculus) 6480464 Phenobarbital results in decreased expression of CYP2A22 protein CTD PMID:35881160 Cyp2a1 Rat phenobarbital increases expression ISO CYP2A13 (Homo sapiens) 6480464 Phenobarbital results in increased expression of CYP2A13 mRNA CTD PMID:22258563 Cyp2a1 Rat pirinixic acid affects expression EXP 6480464 pirinixic acid affects the expression of CYP2A1 mRNA CTD PMID:19483382 Cyp2a1 Rat pregnenolone 16alpha-carbonitrile increases expression EXP 6480464 Pregnenolone Carbonitrile results in increased expression of CYP2A1 mRNA CTD PMID:15596064 Cyp2a1 Rat pyrrolidine dithiocarbamate multiple interactions ISO CYP2A13 (Homo sapiens) 6480464 pyrrolidine dithiocarbamic acid inhibits the reaction [Lipopolysaccharides results in decreased expression of CYP2A13 mRNA] CTD PMID:23884085 Cyp2a1 Rat quinomethionate affects expression ISO CYP2A13 (Homo sapiens) 6480464 quinomethionate affects the expression of CYP2A13 mRNA CTD PMID:15387888 Cyp2a1 Rat quinomethionate increases expression ISO CYP2A13 (Homo sapiens) 6480464 quinomethionate results in increased expression of CYP2A13 mRNA CTD PMID:18214805 Cyp2a1 Rat raloxifene affects expression EXP 6480464 Raloxifene Hydrochloride affects the expression of CYP2A1 mRNA CTD PMID:16079270 Cyp2a1 Rat resveratrol multiple interactions ISO CYP2A13 (Homo sapiens) 6480464 [Plant Extracts co-treated with Resveratrol] results in decreased expression of CYP2A13 mRNA CTD PMID:23557933 Cyp2a1 Rat rifampicin increases expression EXP 6480464 Rifampin results in increased expression of CYP2A1 mRNA CTD PMID:19118567 Cyp2a1 Rat rifampicin decreases expression ISO CYP2A13 (Homo sapiens) 6480464 Rifampin results in decreased expression of CYP2A13 mRNA CTD PMID:22258563 Cyp2a1 Rat rifampicin increases expression ISO CYP2A13 (Homo sapiens) 6480464 Rifampin results in increased expression of CYP2A13 mRNA CTD PMID:22258563 Cyp2a1 Rat semicarbazide multiple interactions EXP 6480464 [carbamylhydrazine results in decreased activity of CYP2A1 protein] which results in decreased abundance of Testosterone metabolite and [carbamylhydrazine results in increased activity of CYP2A1 protein] which results in increased abundance of Testosterone metabolite CTD PMID:19788891 Cyp2a1 Rat semicarbazide increases activity EXP 6480464 carbamylhydrazine results in increased activity of CYP2A1 protein CTD PMID:19788891 Cyp2a1 Rat senecionine increases expression ISO CYP2A13 (Homo sapiens) 6480464 senecionine results in increased expression of CYP2A13 mRNA CTD PMID:26100227 Cyp2a1 Rat skatole multiple interactions ISO CYP2A13 (Homo sapiens) 6480464 [CYP2A13 protein results in increased metabolism of Skatole] which results in increased chemical synthesis of 3-methyleneindolenine more ... CTD PMID:20187624 and PMID:20795680 Cyp2a1 Rat skatole increases metabolic processing ISO CYP2A13 (Homo sapiens) 6480464 CYP2A13 protein results in increased metabolism of Skatole CTD PMID:20187624 Cyp2a1 Rat sodium arsenite decreases expression ISO CYP2A13 (Homo sapiens) 6480464 sodium arsenite results in decreased expression of CYP2A13 mRNA CTD PMID:34032870 Cyp2a1 Rat sodium dichromate decreases expression EXP 6480464 sodium bichromate results in decreased expression of CYP2A1 mRNA CTD PMID:25993096 Cyp2a1 Rat streptozocin decreases expression EXP 6480464 Streptozocin results in decreased expression of CYP2A1 mRNA CTD PMID:25905778 Cyp2a1 Rat streptozocin multiple interactions ISO Cyp2a22 (Mus musculus) 6480464 [Streptozocin co-treated with Dietary Fats co-treated with Diethylhexyl Phthalate] results in increased expression of CYP2A22 mRNA CTD PMID:33484791 Cyp2a1 Rat tamoxifen multiple interactions EXP 6480464 [bexarotene co-treated with Tamoxifen] results in increased expression of CYP2A1 mRNA CTD PMID:17630414 Cyp2a1 Rat taurocholic acid decreases activity EXP 6480464 Taurocholic Acid results in decreased activity of CYP2A1 protein CTD PMID:8889968 Cyp2a1 Rat testosterone affects metabolic processing EXP 6480464 CYP2A1 protein affects the metabolism of Testosterone CTD PMID:15879494 Cyp2a1 Rat testosterone multiple interactions EXP 6480464 [carbamylhydrazine results in decreased activity of CYP2A1 protein] which results in decreased abundance of Testosterone metabolite and [carbamylhydrazine results in increased activity of CYP2A1 protein] which results in increased abundance of Testosterone metabolite CTD PMID:19788891 Cyp2a1 Rat testosterone enanthate decreases expression EXP 6480464 testosterone enanthate results in decreased expression of CYP2A1 protein CTD PMID:8573203 Cyp2a1 Rat tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of CYP2A1 mRNA and Carbon Tetrachloride results in decreased expression of CYP2A1 protein CTD PMID:17606319 and PMID:31150632 Cyp2a1 Rat tetrachloromethane multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2A1 mRNA] CTD PMID:31150632 Cyp2a1 Rat thioacetamide affects expression EXP 6480464 Thioacetamide affects the expression of CYP2A1 mRNA CTD PMID:19483382 Cyp2a1 Rat thioacetamide decreases expression EXP 6480464 Thioacetamide results in decreased expression of CYP2A1 mRNA CTD PMID:34492290 Cyp2a1 Rat toluene increases expression EXP 6480464 Toluene results in increased expression of CYP2A1 protein CTD PMID:8620572 Cyp2a1 Rat tranylcypromine multiple interactions ISO CYP2A13 (Homo sapiens) 6480464 Tranylcypromine inhibits the reaction [CYP2A13 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] CTD PMID:18669584 Cyp2a1 Rat trichloroethene decreases expression EXP 6480464 Trichloroethylene results in decreased expression of CYP2A1 mRNA CTD PMID:19448997 Cyp2a1 Rat trichloroethene increases expression EXP 6480464 Trichloroethylene results in increased expression of CYP2A1 protein CTD PMID:8620572 Cyp2a1 Rat Triptolide multiple interactions ISO Cyp2a22 (Mus musculus) 6480464 TRAJ18 protein affects the reaction [triptolide results in decreased expression of CYP2A1 mRNA] CTD PMID:32987112 Cyp2a1 Rat vinclozolin increases expression EXP 6480464 vinclozolin results in increased expression of CYP2A1 protein CTD PMID:7986207