Cyp1a2 (cytochrome P450, family 1, subfamily a, polypeptide 2) - Rat Genome Database

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Gene: Cyp1a2 (cytochrome P450, family 1, subfamily a, polypeptide 2) Rattus norvegicus
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
RGD ID: 2459
Description: Enables nitrite reductase (NO-forming) activity and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Involved in several processes, including cellular response to copper ion; nitroglycerin metabolic process; and response to vitamin E. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in intracellular membrane-bounded organelle. Biomarker of congestive heart failure and depressive disorder. Human ortholog(s) of this gene implicated in breast cancer; chronic obstructive pulmonary disease; endometrial cancer; and porphyria cutanea tarda. Orthologous to human CYP1A2 (cytochrome P450 family 1 subfamily A member 2); PARTICIPATES IN phase I biotransformation pathway via cytochrome P450; axitinib pharmacokinetics pathway; caffeine pharmacokinetics pathway; INTERACTS WITH (+)-artemisinin; (+)-schisandrin B; (-)-epigallocatechin 3-gallate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cholesterol 25-hydroxylase; CYPD45; CYPIA2; cytochrome P-448; cytochrome P-450d; cytochrome P450 1A2; Cytochrome P450 subfamily I (aromatic compound-inducible) member A2 (Q42 form d); cytochrome P450, 1a2; Cytochrome P450, subfamily I (aromatic compound-inducible), member A2 (Q42, form d); cytochrome P450-D; hydroperoxy icosatetraenoate dehydratase; P-448; P-450d; P450-D; RATCYPD45
RGD Orthologs
Green Monkey
Alliance Genes
More Info more info ...
Candidate Gene For: Mcs4 Hcar3
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8866,971,261 - 66,978,149 (-)NCBIGRCr8
mRatBN7.2858,075,367 - 58,082,255 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl858,075,367 - 58,082,312 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx863,608,316 - 63,615,227 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0861,885,882 - 61,892,795 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0859,750,429 - 59,757,344 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0862,451,360 - 62,458,244 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl862,451,329 - 62,458,301 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0862,228,271 - 62,235,203 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4861,439,062 - 61,447,861 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1861,458,143 - 61,464,586 (-)NCBI
Celera857,541,217 - 57,547,956 (-)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)