Cyp1a1 (cytochrome P450, family 1, subfamily a, polypeptide 1) - Rat Genome Database

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Gene: Cyp1a1 (cytochrome P450, family 1, subfamily a, polypeptide 1) Rattus norvegicus
Symbol: Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
RGD ID: 2458
Description: Enables several functions, including flavonoid 3'-monooxygenase activity; heat shock protein binding activity; and oxidoreductase activity, acting on diphenols and related substances as donors. Contributes to oxidoreductase activity. Involved in several processes, including 9-cis-retinoic acid biosynthetic process; hepatocyte differentiation; and xenobiotic metabolic process. Located in mitochondrial inner membrane. Biomarker of end stage renal disease; heart disease (multiple); hypertension (multiple); and renal cell carcinoma. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); diabetes mellitus (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and lung disease (multiple). Orthologous to human CYP1A1 (cytochrome P450 family 1 subfamily A member 1); PARTICIPATES IN phase I biotransformation pathway via cytochrome P450; gefitinib pharmacokinetics pathway; tamoxifen pharmacokinetics pathway; INTERACTS WITH (+)-alpha-Bisabolol; (+)-catechin; (+)-epicatechin-3-O-gallate.
Type: protein-coding
Previously known as: AHH; AHRR; aryl hydrocarbon hydroxylase; CP11; CYP1; Cyp45c; Cypc45c; CYPIA1; cytochrome P1-450; cytochrome P450 1A1; cytochrome P450 form 6; cytochrome P450 subfamily I (aromatic compound-inducible) member A1 (C6 form c) (C6 form c); cytochrome P450, 1a1; Cytochrome P450, subfamily I (aromatic compound-inducible), member A1 (C6, form c); cytochrome P450, subfamily I (aromatic compound-inducible), member A1 (C6, form c) (C6, form c); cytochrome P450-C; cytochrome P450-P1; cytochrome P450MT2; dioxin-inducible; flavoprotein-linked monooxygenase; hydroperoxy icosatetraenoate dehydratase; microsomal monooxygenase; P-450MC; P1-450; P450-C; P450DX; P450form6; P450MT2; xenobiotic monooxygenase
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Cyp1a1em1Mcwi   Cyp1a1em5Mcwi   Cyp1a1em2Mcwi  
Genetic Models: SS-Cyp1a1em1Mcwi SS-Cyp1a1em2Mcwi SS-Cyp1a1em5Mcwi
Is Marker For: Strains:   F344-Tg(Cyp1a1-Ren2)10Jmul  
Candidate Gene For: Mcs4 Hcar3
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8866,991,940 - 66,998,014 (+)NCBIGRCr8
mRatBN7.2858,096,021 - 58,102,130 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl858,096,077 - 58,102,125 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx863,629,083 - 63,635,108 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0861,906,655 - 61,912,680 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0859,771,206 - 59,777,229 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0862,472,087 - 62,478,122 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl862,472,095 - 62,478,147 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0862,249,046 - 62,255,081 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4861,462,207 - 61,468,237 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1861,481,260 - 61,487,291 (+)NCBI
Celera857,561,801 - 57,567,827 (+)NCBICelera
RH 3.4 Map8671.2RGD
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)