Cyp11b2 (cytochrome P450, family 11, subfamily b, polypeptide 2) - Rat Genome Database

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Gene: Cyp11b2 (cytochrome P450, family 11, subfamily b, polypeptide 2) Rattus norvegicus
Analyze
Symbol: Cyp11b2 (Ensembl: Cyp11b3)
Name: cytochrome P450, family 11, subfamily b, polypeptide 2 (Ensembl:cytochrome P450, family 11, subfamily b, polypeptide 3)
RGD ID: 2454
Description: Enables corticosterone 18-monooxygenase activity and steroid 11-beta-monooxygenase activity. Involved in several processes, including cellular response to mechanical stimulus; cellular response to potassium ion starvation; and steroid hormone biosynthetic process. Located in dendrite. Used to study heart disease; hypertension; and myocardial infarction. Biomarker of congestive heart failure; hypertension; myocarditis; and renal tubular acidosis. Human ortholog(s) of this gene implicated in congenital adrenal hyperplasia; glucocorticoid-remediable aldosteronism; and primary hyperaldosteronism. Orthologous to human CYP11B1 (cytochrome P450 family 11 subfamily B member 1); PARTICIPATES IN C21-steroid hormone biosynthetic pathway; 11-beta-hydroxylase deficiency pathway; 17-alpha-hydroxylase deficiency pathway; INTERACTS WITH (S)-nicotine; 11-deoxycorticosterone; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ALDOS; aldosterone synthase; aldosterone-synthesizing enzyme; corticosterone 18-monooxygenase, CYP11B2; Cp45as; Cyp11b3; CYPXIB2; CYPXIB3; cytochrome P-450 11B3; cytochrome P-450Aldo; cytochrome P-450C18; cytochrome P450 11B2, mitochondrial; cytochrome P450 11B3, mitochondrial; Cytochrome P450 subfamily XIB polypeptide 2 (aldosterone synthase); cytochrome P450(11beta,aldo); cytochrome P450, subfamily 11B, polypeptide 2; Cytochrome P450, subfamily XIB, polypeptide 2 (aldosterone synthase); cytochrome P450-Aldo-1; cytochrome P450-Aldo-2; P450(11beta,aldo); P450-Aldo-1; P450-Aldo-2; RNCP45AS; steroid 11-beta-hydroxylase; steroid 11-beta-hydroxylase, CYP11B2; steroid 18-hydroxylase
RGD Orthologs
Human
Bonobo
Green Monkey
Alliance Orthologs
More Info more info ...
Allele / Splice: Cyp11b2m1  
Is Marker For: Strains:   SS.LEW-(D7Rat73-D7Rat128)/Ayd   LEW.SS-(D7Rat73-D7Rat128)/Ayd  
Candidate Gene For: Eau6
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87108,719,349 - 108,726,024 (-)NCBIGRCr8
mRatBN7.27106,838,590 - 106,845,004 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7106,838,590 - 106,845,004 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7108,564,515 - 108,570,947 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07110,788,181 - 110,794,613 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07110,734,122 - 110,740,554 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07116,248,759 - 116,255,205 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7116,156,219 - 116,255,167 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07116,151,128 - 116,157,542 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47113,043,365 - 113,049,779 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17113,077,595 - 113,084,003 (-)NCBI
Celera7103,210,977 - 103,217,398 (-)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (EXP)
11-deoxycorticosterone  (EXP,ISO)
11-deoxycortisol  (ISO)
18-hydroxycortisol  (ISO)
18-hydroxydeoxycorticosterone  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,3',4,4',5-Hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
3',4'-dimethoxyflavone  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol  (ISO)
3,4,5,3',4',5'-Hexachlorobiphenyl  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile  (ISO)
8-Br-cAMP  (ISO)
alpha-naphthoflavone  (ISO)
androgen antagonist  (EXP)
apigenin  (ISO)
benidipine  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bifenthrin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
bucladesine  (ISO)
Butylbenzyl phthalate  (EXP)
Butylparaben  (EXP)
caffeine  (EXP)
colforsin daropate hydrochloride  (ISO)
corticosterone  (ISO)
cortisol  (ISO)
cyproconazole  (EXP)
DDE  (EXP)
decabromodiphenyl ether  (EXP)
deoxynivalenol  (ISO)
dexamethasone  (EXP)
Di-n-hexyl phthalate  (EXP)
dibutyl phthalate  (EXP)
Dicyclohexyl phthalate  (EXP)
diethyl phthalate  (EXP)
diheptyl phthalate  (EXP)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dipentyl phthalate  (EXP)
enniatin  (ISO)
enzacamene  (EXP)
epoxiconazole  (EXP)
ethanol  (ISO)
furan  (EXP)
gamma-hexachlorocyclohexane  (ISO)
gentamycin  (EXP)
hydroxyitraconazole  (ISO)
itraconazole  (ISO)
ketoconazole  (ISO)
Methandrostenolone  (ISO)
methylmercury chloride  (ISO)
Mitotane  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (ISO)
nicotine  (EXP)
paracetamol  (EXP)
perflubron  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pirinixic acid  (EXP)
posaconazole  (ISO)
potassium chloride  (ISO)
proanthocyanidin  (ISO)
prochloraz  (EXP,ISO)
quercetin  (ISO)
rotenone  (ISO)
simvastatin  (EXP)
testosterone  (EXP)
tetramethylpyrazine  (ISO)
toluene  (EXP)
torcetrapib  (ISO)
triadimefon  (EXP)
tributylstannane  (ISO)
trichloroethene  (EXP)
triphenylstannane  (EXP,ISO)
Triptolide  (ISO)
triticonazole  (EXP)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Fetal adrenal gland alterations in a rat model of adverse intrauterine environment. Bibeau K, etal., Am J Physiol Regul Integr Comp Physiol. 2010 Apr;298(4):R899-911. Epub 2009 Nov 18.
2. Aldosterone excretion rate and blood pressure in essential hypertension are related to polymorphic differences in the aldosterone synthase gene CYP11B2. Davies E, etal., Hypertension. 1999 Feb;33(2):703-7.
3. Quantitative assessment of CYP11B1 and CYP11B2 expression in aldosterone-producing adenomas. Fallo F, etal., Eur J Endocrinol. 2002 Dec;147(6):795-802.
4. Metabolic acidosis has dual effects on sodium handling by rat kidney. Faroqui S, etal., Am J Physiol Renal Physiol. 2006 Aug;291(2):F322-31. Epub 2006 Feb 21.
5. Aldosterone synthase inhibitor ameliorates angiotensin II-induced organ damage. Fiebeler A, etal., Circulation. 2005 Jun 14;111(23):3087-94. Epub 2005 Jun 6.
6. Mineralocorticoid receptor antagonist spironolactone prevents pig serum-induced hepatic fibrosis in rats. Fujisawa G, etal., Transl Res. 2006 Sep;148(3):149-56.
7. Cardiac specific increase in aldosterone production induces coronary dysfunction in aldosterone synthase-transgenic mice. Garnier A, etal., Circulation. 2004 Sep 28;110(13):1819-25. Epub 2004 Sep 13.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Aldosterone synthesis in the brain contributes to Dahl salt-sensitive rat hypertension. Gomez-Sanchez EP, etal., Exp Physiol. 2010 Jan;95(1):120-30. Epub 2009 Oct 16.
11. Central infusion of aldosterone synthase inhibitor prevents sympathetic hyperactivity and hypertension by central Na+ in Wistar rats. Huang BS, etal., Am J Physiol Regul Integr Comp Physiol. 2008 Jul;295(1):R166-72. Epub 2008 May 21.
12. Role of central nervous system aldosterone synthase and mineralocorticoid receptors in salt-induced hypertension in Dahl salt-sensitive rats. Huang BS, etal., Am J Physiol Regul Integr Comp Physiol. 2009 Apr;296(4):R994-R1000. Epub 2008 Dec 31.
13. Central infusion of aldosterone synthase inhibitor attenuates left ventricular dysfunction and remodelling in rats after myocardial infarction. Huang BS, etal., Cardiovasc Res. 2009 Feb 15;81(3):574-81. Epub 2008 Aug 8.
14. Molecular cloning of a cDNA encoding aldosterone synthase cytochrome P-450 in rat adrenal cortex. Imai M, etal., FEBS Lett 1990 Apr 24;263(2):299-302.
15. Inhibitory effect of natriuretic peptides on aldosterone synthase gene expression in cultured neonatal rat cardiocytes. Ito T, etal., Circulation 2003 Feb 18;107(6):807-10.
16. Genetic variation at the locus encompassing 11-beta hydroxylase and aldosterone synthase accounts for heritability in cortisol precursor (11-deoxycortisol) urinary metabolite excretion. Keavney B, etal., J Clin Endocrinol Metab. 2005 Feb;90(2):1072-7. Epub 2004 Nov 2.
17. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
18. Polymorphism of the aldosterone synthase gene is not associated with progression of diabetic nephropathy, but associated with hypertension in type 2 diabetic patients. Ko GJ, etal., Nephrology (Carlton). 2008 Dec;13(6):492-9. Epub 2008 Sep 1.
19. Associations between human aldosterone synthase (CYP11B2) gene polymorphisms and left ventricular size, mass, and function. Kupari M, etal., Circulation. 1998 Feb 17;97(6):569-75.
20. Aldosterone promotes fibronectin production through a Smad2-dependent TGF-beta1 pathway in mesangial cells. Lai L, etal., Biochem Biophys Res Commun. 2006 Sep 15;348(1):70-5. Epub 2006 Jul 21.
21. Activation of local aldosterone system within podocytes is involved in apoptosis under diabetic conditions. Lee SH, etal., Am J Physiol Renal Physiol. 2009 Nov;297(5):F1381-90. Epub 2009 Aug 26.
22. Mutations in aldosterone synthase gene of Milan hypertensive rats: phenotypic consequences. Lloyd-MacGilp SA, etal., Am J Physiol Endocrinol Metab 2002 Mar;282(3):E608-17.
23. 11beta-hydroxylase and aldosterone synthase expression in fetal rat hippocampal neurons. MacKenzie SM, etal., J Mol Endocrinol. 2002 Dec;29(3):319-25.
24. Molecular cloning and expression of cDNAS encoding rat aldosterone synthase: variants of cytochrome P-450(11 beta). Matsukawa N, etal., Biochem Biophys Res Commun 1990 May 31;169(1):245-52.
25. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
26. Isolation and characterization of rat CYP11B genes involved in late steps of mineralo- and glucocorticoid syntheses. Mukai K, etal., J Biol Chem 1993 Apr 25;268(12):9130-7.
27. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
28. The involvement of aldosterone in cyclic stretch-mediated activation of NADPH oxidase in vascular smooth muscle cells. Ohmine T, etal., Hypertens Res. 2009 Aug;32(8):690-9. Epub 2009 May 29.
29. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
30. Lack of association among five genetic polymorphisms of the renin-angiotensin system and cardiac hypertrophy in patients with aortic stenosis. Ortlepp JR, etal., Am Heart J. 2001 Apr;141(4):671-6.
31. Mutations in the human CYP11B2 (aldosterone synthase) gene causing corticosterone methyloxidase II deficiency. Pascoe L, etal., Proc Natl Acad Sci U S A. 1992 Jun 1;89(11):4996-5000.
32. Variants of trophic factors and expression of cardiac hypertrophy in patients with hypertrophic cardiomyopathy. Patel R, etal., J Mol Cell Cardiol. 2000 Dec;32(12):2369-77.
33. Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones. Payne AH and Hales DB, Endocr Rev. 2004 Dec;25(6):947-70.
34. StAR expression and the long-term aldosterone response to high-potassium diet in Wistar-Kyoto and spontaneously hypertensive rats. Peters B, etal., Am J Physiol Endocrinol Metab. 2007 Jan;292(1):E16-23. Epub 2006 Aug 1.
35. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
36. Chronic renal insufficiency among Asian Indians with type 2 diabetes: I. Role of RAAS gene polymorphisms. Prasad P, etal., BMC Med Genet. 2006 May 3;7:42.
37. Genetic variation in aldosterone synthase predicts plasma glucose levels. Ranade K, etal., Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13219-24. Epub 2001 Oct 30.
38. GOA pipeline RGD automated data pipeline
39. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
40. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
41. -344C/T Variant in the promoter of the aldosterone synthase gene (CYP11B2) is associated with metabolic syndrome in men. Russo P, etal., Am J Hypertens. 2007 Feb;20(2):218-22.
42. Aldosterone synthase gene polymorphism, stroke volume and age-related changes in aortic pulse wave velocity in subjects with hypertension. Safar ME, etal., J Hypertens. 2005 Jun;23(6):1159-66.
43. Evidence for compromised aldosterone synthase enzyme activity in preeclampsia. Shojaati K, etal., Kidney Int. 2004 Dec;66(6):2322-8.
44. Regulation of aldosterone and cortisol production by the transcriptional repressor neuron restrictive silencer factor. Somekawa S, etal., Endocrinology. 2009 Jul;150(7):3110-7. Epub 2009 Apr 2.
45. Spironolactone exhibits direct renoprotective effects and inhibits renal renin-angiotensin-aldosterone system in diabetic rats. Taira M, etal., Eur J Pharmacol. 2008 Jul 28;589(1-3):264-71. Epub 2008 Jun 10.
46. [Effects of various diuretics on cardiac function in rats with heart failure]. Tanaka H, etal., Yakugaku Zasshi. 2009 Jul;129(7):871-9.
47. Sodium depletion increases sympathetic neurite outgrowth and expression of a novel TMEM35 gene-derived protein (TUF1) in the rat adrenal zona glomerulosa. Tran PV, etal., Endocrinology. 2010 Oct;151(10):4852-60. Epub 2010 Aug 4.
48. Torasemide, a long-acting loop diuretic, reduces the progression of myocarditis to dilated cardiomyopathy. Veeraveedu PT, etal., Eur J Pharmacol. 2008 Feb 26;581(1-2):121-31. Epub 2007 Nov 28.
49. Local renal aldosterone system and its regulation by salt, diabetes, and angiotensin II type 1 receptor. Xue C and Siragy HM, Hypertension. 2005 Sep;46(3):584-90. Epub 2005 Jul 25.
50. Effects of ACTH, dexamethasone, and adrenalectomy on 11beta-hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2) gene expression in the rat central nervous system. Ye P, etal., J Endocrinol. 2008 Feb;196(2):305-11.
51. Cloning and expression of a rat cytochrome P-450 11 beta-hydroxylase/aldosterone synthase (CYP11B2) cDNA variant. Zhou M and Gomez-Sanchez CE, Biochem Biophys Res Commun 1993 Jul 15;194(1):112-7.
Additional References at PubMed
PMID:1562515   PMID:1686470   PMID:2022736   PMID:2256920   PMID:2738055   PMID:8468320   PMID:8506298   PMID:8645611   PMID:12865309   PMID:16118390   PMID:16179417   PMID:19001524  
PMID:19418629   PMID:21818974   PMID:22217827   PMID:25957425   PMID:29739797  


Genomics

Comparative Map Data
Cyp11b2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87108,719,349 - 108,726,024 (-)NCBIGRCr8
mRatBN7.27106,838,590 - 106,845,004 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7106,838,590 - 106,845,004 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7108,564,515 - 108,570,947 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07110,788,181 - 110,794,613 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07110,734,122 - 110,740,554 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07116,248,759 - 116,255,205 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7116,156,219 - 116,255,167 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07116,151,128 - 116,157,542 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47113,043,365 - 113,049,779 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17113,077,595 - 113,084,003 (-)NCBI
Celera7103,210,977 - 103,217,398 (-)NCBICelera
Cytogenetic Map7q34NCBI
CYP11B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388142,872,357 - 142,879,825 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8142,872,356 - 142,879,846 (-)EnsemblGRCh38hg38GRCh38
GRCh378143,953,773 - 143,961,241 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368143,950,775 - 143,958,238 (-)NCBINCBI36Build 36hg18NCBI36
Build 348143,952,217 - 143,958,238NCBI
Celera8140,263,402 - 140,270,865 (-)NCBICelera
Cytogenetic Map8q24.3NCBI
HuRef8139,206,042 - 139,213,505 (-)NCBIHuRef
CHM1_18143,994,059 - 144,001,520 (-)NCBICHM1_1
T2T-CHM13v2.08144,015,692 - 144,023,160 (-)NCBIT2T-CHM13v2.0
CYP11B1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27160,309,139 - 160,316,623 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18135,835,342 - 135,842,827 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08139,584,976 - 139,592,466 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18142,628,706 - 142,634,654 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8142,629,127 - 142,634,654 (-)Ensemblpanpan1.1panPan2
CYP11B1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18137,125,409 - 137,132,267 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660392,814,491 - 2,820,047 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Cyp11b2
67 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:369
Count of miRNA genes:228
Interacting mature miRNAs:266
Transcripts:ENSRNOT00000041774
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)794811326116294265Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)769736356112729554Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7103146217116738842Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)793595647106839474Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)780221299109401111Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)794811085116738842Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)768938720113886318Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)780221299112308525Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)768938720113886318Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)768938720113886318Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)769736226117455174Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat

Markers in Region
D7Wox19  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27106,839,225 - 106,839,474 (+)MAPPERmRatBN7.2
Rnor_6.07116,249,395 - 116,249,643NCBIRnor6.0
Rnor_5.07116,151,764 - 116,152,012UniSTSRnor5.0
RGSC_v3.47113,044,000 - 113,044,249RGDRGSC3.4
RGSC_v3.47113,044,001 - 113,044,249UniSTSRGSC3.4
RGSC_v3.17113,078,230 - 113,078,479RGD
Celera7103,211,613 - 103,211,868UniSTS
RH 3.4 Map7772.3UniSTS
RH 3.4 Map7772.3RGD
RH 2.0 Map7606.1RGD
Cytogenetic Map7q34UniSTS
D7Wox16  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.07116,151,707 - 116,151,991NCBIRnor5.0
Rnor_5.07116,098,481 - 116,098,761NCBIRnor5.0
Rnor_5.07116,058,408 - 116,058,688NCBIRnor5.0
RGSC_v3.47113,012,736 - 113,013,015RGDRGSC3.4
RGSC_v3.47113,043,945 - 113,044,228RGDRGSC3.4
RGSC_v3.47112,977,966 - 112,978,266RGDRGSC3.4
RGSC_v3.17113,012,196 - 113,012,496RGD
Celera7103,211,558 - 103,211,847UniSTS
Celera7103,180,377 - 103,180,655UniSTS
RH 3.4 Map7771.9RGD
RH 3.4 Map7771.9UniSTS
RH 2.0 Map7605.5RGD
Cytogenetic Map7q34UniSTS
D7Wox46  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27106,845,277 - 106,845,450 (+)MAPPERmRatBN7.2
Rnor_6.07116,255,624 - 116,255,796NCBIRnor6.0
Rnor_5.07116,157,993 - 116,158,165UniSTSRnor5.0
RGSC_v3.47113,050,053 - 113,050,225UniSTSRGSC3.4
Celera7103,217,672 - 103,217,844UniSTS
Cytogenetic Map7q34UniSTS


Related Rat Strains
The following Strains have been annotated to Cyp11b2
LEW.SS-(D7Rat73-D7Rat128)/Ayd     SS.LEW-(D7Rat73-D7Rat128)/Ayd    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
8 9 14 72 57 55 25 25 25 6 119 60 52 18 48 30

Sequence


RefSeq Acc Id: NM_012538   ⟹   NP_036670
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87108,719,349 - 108,725,763 (-)NCBI
mRatBN7.27106,838,590 - 106,845,004 (-)NCBI
Rnor_6.07116,248,759 - 116,255,173 (-)NCBI
Rnor_5.07116,151,128 - 116,157,542 (-)NCBI
RGSC_v3.47113,043,365 - 113,049,779 (-)RGD
Celera7103,210,977 - 103,217,398 (-)RGD
Sequence:
RefSeq Acc Id: XM_063262976   ⟹   XP_063119046
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87108,719,355 - 108,726,024 (-)NCBI
Protein Sequences
Protein RefSeqs NP_036670 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119046 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA00445 (Get FASTA)   NCBI Sequence Viewer  
  BAA03172 (Get FASTA)   NCBI Sequence Viewer  
  CAA36978 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000079048
GenBank Protein P30099 (Get FASTA)   NCBI Sequence Viewer  
  P30100 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036670   ⟸   NM_012538
- UniProtKB: P30100 (UniProtKB/Swiss-Prot),   F1LPS4 (UniProtKB/TrEMBL),   A6HRZ3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_063119046   ⟸   XM_063262976
- Peptide Label: isoform X1
- UniProtKB: P30100 (UniProtKB/Swiss-Prot)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P30100-F1-model_v2 AlphaFold P30100 1-500 view protein structure
AF-P30099-F1-model_v2 AlphaFold P30099 1-510 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2454 AgrOrtholog
BioCyc Gene G2FUF-33005 BioCyc
Ensembl Genes ENSRNOG00000030111 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000101557 ENTREZGENE
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot
InterPro CYP11_CYP27_families UniProtKB/Swiss-Prot
  Cyt_P450 UniProtKB/Swiss-Prot
  Cyt_P450_CS UniProtKB/Swiss-Prot
  Cyt_P450_mitochondrial UniProtKB/Swiss-Prot
  Cyt_P450_sf UniProtKB/Swiss-Prot
NCBI Gene 24294 ENTREZGENE
PANTHER CYTOCHROME P450 11B2, MITOCHONDRIAL UniProtKB/Swiss-Prot
  PTHR24279 UniProtKB/Swiss-Prot
Pfam p450 UniProtKB/Swiss-Prot
PharmGKB CYP11B2 RGD
PhenoGen Cyp11b2 PhenoGen
PRINTS MITP450 UniProtKB/Swiss-Prot
  P450 UniProtKB/Swiss-Prot
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000030111 RatGTEx
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot
UniProt A0A8I5ZMM4_RAT UniProtKB/TrEMBL
  A6HRZ3 ENTREZGENE, UniProtKB/TrEMBL
  C11B2_RAT UniProtKB/Swiss-Prot
  C11B3_RAT UniProtKB/Swiss-Prot
  F1LPS4 ENTREZGENE, UniProtKB/TrEMBL
  P30099 ENTREZGENE
  P30100 ENTREZGENE
UniProt Secondary Q64540 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-19 Cyp11b2  cytochrome P450, family 11, subfamily b, polypeptide 2  Cyp11b2  cytochrome P450, subfamily 11B, polypeptide 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-07   cytochrome P450, subfamily 11B, polypeptide 2  Cyp11b2  cytochrome P450, family 11, subfamily B, polypeptide 2  Name updated 1299863 APPROVED
2004-09-10 Cyp11b2  cytochrome P450, family 11, subfamily B, polypeptide 2    cytochrome P450, subfamily 11B, polypeptide 2  Name updated 1299863 APPROVED
2002-11-06 Cyp11b2  cytochrome P450, subfamily 11B, polypeptide 2    Cytochrome P450, subfamily XIB, polypeptide 2 (aldosterone synthase)  Name updated 625702 APPROVED
2002-06-10 Cyp11b2  Cytochrome P450, subfamily XIB, polypeptide 2 (aldosterone synthase)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process regulates corticosterone and aldosterone synthesis 727991
gene_protein 500 amino acid residues 727586