Cstb (cystatin B) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Cstb (cystatin B) Rattus norvegicus
Analyze
Symbol: Cstb
Name: cystatin B
RGD ID: 2435
Description: Predicted to enable cysteine-type endopeptidase inhibitor activity and protease binding activity. Predicted to be involved in amyloid fibril formation and negative regulation of proteolysis. Predicted to act upstream of or within adult locomotory behavior. Predicted to be located in cytoplasm; extracellular space; and nucleus. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in Unverricht-Lundborg syndrome and progressive myoclonus epilepsy 1A. Orthologous to human CSTB (cystatin B); INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CYB; cystatin B (stefin B); Cystatin beta; cystatin-B; cystatin-beta; EPM1; liver thiol proteinase inhibitor; MGC105499; stefin-B; Stfb
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82010,245,157 - 10,247,199 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2010,245,158 - 10,247,199 (-)EnsemblGRCr8
mRatBN7.22010,245,462 - 10,247,505 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2010,245,462 - 10,247,526 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2010,945,142 - 10,947,182 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02010,306,047 - 10,308,087 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02010,777,526 - 10,779,568 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02010,966,357 - 10,968,399 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2010,966,331 - 10,968,432 (-)Ensemblrn6Rnor6.0
Rnor_5.02013,137,896 - 13,139,938 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42010,576,664 - 10,578,706 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2011,756,111 - 11,758,153 (-)NCBICelera
RGSC_v3.12010,576,891 - 10,578,923 (-)NCBI
Cytogenetic Map20p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-nitrofluorene  (EXP)
3',5'-cyclic AMP  (EXP)
3,4-dichloroaniline  (ISO)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (ISO)
Allylamine  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
arsenous acid  (ISO)
ATP  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
chloropicrin  (ISO)
choline  (ISO)
ciglitazone  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP,ISO)
dibenzo[a,l]pyrene  (ISO)
dieldrin  (EXP)
diethylstilbestrol  (EXP,ISO)
dioxygen  (ISO)
diuron  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenamidone  (ISO)
fipronil  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fumonisin B1  (ISO)
furfural  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
griseofulvin  (ISO)
isoflurane  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
Mesaconitine  (EXP)
methamphetamine  (EXP)
methapyrilene  (EXP)
microcystin-LR  (ISO)
morphine  (EXP)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP)
Nutlin-3  (ISO)
ochratoxin A  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorodecanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluoroundecanoic acid  (ISO)
phenobarbital  (ISO)
phosgene  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propiconazole  (ISO)
rotenone  (EXP)
sarin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tetrachloromethane  (ISO)
tetrahydropalmatine  (ISO)
tetrathiomolybdate(2-)  (ISO)
thapsigargin  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tolcapone  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA,ISO)
cytosol  (IBA,IEA,ISO)
extracellular space  (IEA,ISO)
nucleolus  (IEA,ISO)
nucleus  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Seizures induce widespread upregulation of cystatin B, the gene mutated in progressive myoclonus epilepsy, in rat forebrain neurons. D'Amato E, etal., Eur J Neurosci 2000 May;12(5):1687-95.
2. [Physical training aspect of exercise testing: the evaluation of Master's double 2 step test, augmented Master's test and Cooper's submaximum single-level load exercise test (author's transl)]. Fukuda I, etal., Kokyu To Junkan. 1975 Nov;23(11):985-92.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Structural organization of the gene encoding rat cystatin beta. Sato N, etal., Gene 1992 May 15;114(2):257-60.
12. Molecular cloning and sequencing of cDNA for rat cystatin beta. Sato N, etal., Nucleic Acids Res 1990 Nov 25;18(22):6698.
13. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
14. Cystatin B and SOD1: protein–protein interaction and possible relation to neurodegeneration. Ulbrich L, etal., Cell Mol Neurobiol. 2014 Mar;34(2):205-13. doi: 10.1007/s10571-013-0004-y.
Additional References at PubMed
PMID:3053245   PMID:3488317   PMID:6203523   PMID:6626228   PMID:9806543   PMID:11139332   PMID:11514663   PMID:12477932   PMID:12901878   PMID:15277470   PMID:15489334   PMID:19056867  
PMID:19199708   PMID:22658674   PMID:23376485   PMID:23533145   PMID:23580065   PMID:24063889   PMID:30052474  


Genomics

Comparative Map Data
Cstb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82010,245,157 - 10,247,199 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2010,245,158 - 10,247,199 (-)EnsemblGRCr8
mRatBN7.22010,245,462 - 10,247,505 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2010,245,462 - 10,247,526 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2010,945,142 - 10,947,182 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02010,306,047 - 10,308,087 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02010,777,526 - 10,779,568 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02010,966,357 - 10,968,399 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2010,966,331 - 10,968,432 (-)Ensemblrn6Rnor6.0
Rnor_5.02013,137,896 - 13,139,938 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42010,576,664 - 10,578,706 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2011,756,111 - 11,758,153 (-)NCBICelera
RGSC_v3.12010,576,891 - 10,578,923 (-)NCBI
Cytogenetic Map20p12NCBI
CSTB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382143,773,950 - 43,776,308 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2143,772,511 - 43,776,579 (-)Ensemblhg38GRCh38
GRCh372145,193,831 - 45,196,189 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362144,018,259 - 44,020,687 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342144,018,259 - 44,020,687NCBI
Celera2130,299,423 - 30,301,851 (-)NCBICelera
Cytogenetic Map21q22.3NCBI
HuRef2130,561,944 - 30,564,654 (-)NCBIHuRef
CHM1_12144,754,030 - 44,756,740 (-)NCBICHM1_1
T2T-CHM13v2.02142,129,562 - 42,131,920 (-)NCBIT2T-CHM13v2.0
Cstb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391078,261,504 - 78,263,456 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1078,261,503 - 78,263,456 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381078,425,670 - 78,427,622 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1078,425,669 - 78,427,622 (+)Ensemblmm10GRCm38
MGSCv371077,888,415 - 77,890,367 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361077,828,799 - 77,830,751 (+)NCBIMGSCv36mm8
Celera1079,447,767 - 79,449,719 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Cstb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540741,475,533 - 41,479,150 (+)Ensembl
ChiLan1.0NW_00495540741,475,533 - 41,478,943 (+)NCBIChiLan1.0ChiLan1.0
CSTB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22239,780,301 - 39,783,181 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12134,630,903 - 34,633,448 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02130,030,359 - 30,032,899 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12143,329,002 - 43,343,874 (-)NCBIPanPan1.1PanPan1.1panPan2
CSTB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha3136,873,130 - 36,876,156 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03137,261,684 - 37,264,733 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3137,261,716 - 37,264,743 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13137,129,434 - 37,132,462 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03137,115,288 - 37,118,267 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03137,607,453 - 37,610,501 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cstb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497136,964,516 - 36,965,388 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936500502,237 - 503,578 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936500502,444 - 503,307 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CSTB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13206,706,063 - 206,710,646 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.113206,706,060 - 206,710,598 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CSTB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1287,551,341 - 87,555,145 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605415,620,453 - 15,625,359 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cstb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474530,153,023 - 30,155,712 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474530,152,988 - 30,155,704 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Cstb
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1181,711,640 - 1,713,738 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cstb
28 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:156
Count of miRNA genes:110
Interacting mature miRNAs:114
Transcripts:ENSRNOT00000001593
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)20418947649189476Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20126925056Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20133724594Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126128279Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804392029865039Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600300Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20153308346533083Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124164241Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20134066551Rat
631265Iresp1Immunoglobin response QTL18.3blood anti-double stranded DNA antibody amount (VT:0004762)serum anti-DNA antibody level (CMO:0001533)20904109911115921Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129193376Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20127341128Rat
1598870Bp289Blood pressure QTL 2892.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)20821635953216359Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129193376Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129193376Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129193376Rat
1581577Pur15Proteinuria QTL 154.380.0002urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)20804392015089182Rat
1598858Cm61Cardiac mass QTL 613.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)20821635953216359Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129193376Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20114100378Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578510Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600300Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000001593   ⟹   ENSRNOP00000001593
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2010,245,158 - 10,247,199 (-)Ensembl
mRatBN7.2 Ensembl2010,245,462 - 10,247,526 (-)Ensembl
Rnor_6.0 Ensembl2010,966,331 - 10,968,432 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108042   ⟹   ENSRNOP00000077618
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2010,245,462 - 10,246,891 (-)Ensembl
RefSeq Acc Id: NM_012838   ⟹   NP_036970
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82010,245,157 - 10,247,199 (-)NCBI
mRatBN7.22010,245,462 - 10,247,505 (-)NCBI
Rnor_6.02010,966,357 - 10,968,399 (-)NCBI
Rnor_5.02013,137,896 - 13,139,938 (-)NCBI
RGSC_v3.42010,576,664 - 10,578,706 (-)RGD
Celera2011,756,111 - 11,758,153 (-)RGD
Sequence:
RefSeq Acc Id: NP_036970   ⟸   NM_012838
- UniProtKB: P01041 (UniProtKB/Swiss-Prot),   A6JK25 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000001593   ⟸   ENSRNOT00000001593
Ensembl Acc Id: ENSRNOP00000077618   ⟸   ENSRNOT00000108042
Protein Domains
Cystatin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P01041-F1-model_v2 AlphaFold P01041 1-98 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701484
Promoter ID:EPDNEW_R12008
Type:initiation region
Name:Cstb_1
Description:cystatin B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02010,968,388 - 10,968,448EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2435 AgrOrtholog
BioCyc Gene G2FUF-4285 BioCyc
Ensembl Genes ENSRNOG00000001201 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000001593 ENTREZGENE
  ENSRNOT00000001593.5 UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.450.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7318993 IMAGE-MGC_LOAD
InterPro Cystatin_dom UniProtKB/Swiss-Prot
  Cystatin_sf UniProtKB/Swiss-Prot
  Prot_inh_cystat_CS UniProtKB/Swiss-Prot
  Prot_inh_stefin UniProtKB/Swiss-Prot
KEGG Report rno:25308 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105499 IMAGE-MGC_LOAD
NCBI Gene 25308 ENTREZGENE
PANTHER CYSTATIN-B UniProtKB/Swiss-Prot
  PTHR11414 UniProtKB/Swiss-Prot
Pfam Cystatin UniProtKB/Swiss-Prot
PhenoGen Cstb PhenoGen
PRINTS STEFINA UniProtKB/Swiss-Prot
PROSITE CYSTATIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001201 RatGTEx
SMART SM00043 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54403 UniProtKB/Swiss-Prot
TIGR TC228584
UniProt A6JK23_RAT UniProtKB/TrEMBL
  A6JK24_RAT UniProtKB/TrEMBL
  A6JK25 ENTREZGENE, UniProtKB/TrEMBL
  A6JK26_RAT UniProtKB/TrEMBL
  CYTB_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-23 Cstb  cystatin B  Cstb  cystatin B (stefin B)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-26 Cstb  cystatin B (stefin B)  Cstb  cystatin B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Cstb  cystatin B    Cystatin beta  Name updated 625702 APPROVED
2002-06-10 Cstb  Cystatin beta      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease mutation of the human homolog causes progressive myoclonus epilepsy EPM1 729930