Crp (C-reactive protein) - Rat Genome Database

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Gene: Crp (C-reactive protein) Rattus norvegicus
Symbol: Crp
Name: C-reactive protein
RGD ID: 2411
Description: Enables cholesterol binding activity; identical protein binding activity; and low-density lipoprotein particle binding activity. Involved in several processes, including cellular response to nitric oxide; complement activation, classical pathway; and negative regulation of superoxide anion generation. Located in extracellular space; filopodium; and growth cone. Used to study rheumatoid arthritis. Biomarker of several diseases, including acute kidney failure; artery disease (multiple); iron deficiency anemia; obesity; and status epilepticus. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune disease (multiple); macular degeneration (multiple); middle cerebral artery infarction; and nephritis (multiple). Orthologous to human CRP (C-reactive protein); PARTICIPATES IN classical complement pathway; interleukin-6 signaling pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; (R)-lipoic acid; 1,1-dichloroethene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Aa1249; Ab1-341; Ab2-196; Ac1-114; Ac1262; Ac2-069; Ba2-693; C-reactive protein member of the pentraxin family; C-reactive protein, member of the pentraxin family; C-reactive protein, pentraxin-related; C-reactive protein, petaxin related
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81387,694,062 - 87,695,978 (+)NCBIGRCr8
mRatBN7.21385,135,384 - 85,175,178 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1385,124,977 - 85,175,178 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1387,664,967 - 87,666,915 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01389,065,246 - 89,067,190 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01386,249,976 - 86,251,928 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01391,080,448 - 91,081,358 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1391,054,974 - 91,093,713 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01395,599,418 - 95,600,328 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41388,702,243 - 88,703,153 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11388,891,058 - 88,892,928 (+)NCBI
Celera1384,770,843 - 84,771,753 (+)NCBICelera
Cytogenetic Map13q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Acute Coronary Syndrome  (ISO)
acute kidney failure  (IEP,ISO)
acute stress disorder  (ISO)
Acute Uveitis  (IEP,ISO)
aggressive periodontitis  (ISO)
Albuminuria  (ISO)
Alcoholic Fatty Liver  (IEP)
alcoholic liver cirrhosis  (ISO)
Alzheimer's disease  (ISO)
ankylosing spondylitis  (ISO)
antiphospholipid syndrome  (ISO)
anxiety disorder  (ISO)
Arsenic Poisoning  (ISO)
aspergillosis  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
atrial fibrillation  (ISO)
autoimmune interstitial lung, joint, and kidney disease  (ISO)
Bacteremia  (ISO)
bacterial infectious disease  (ISO)
bacterial meningitis  (ISO)
Behcet's disease  (ISO)
Brain Hypoxia-Ischemia  (ISO)
Brain Injuries  (ISO)
breast cancer  (ISO)
breast carcinoma  (ISO)
bronchiolitis  (ISO)
Burns  (IEP)
Cardiac Arrhythmias  (ISO)
cardiovascular system disease  (ISO)
cerebrovascular disease  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chronic Hepatitis C  (ISO)
chronic obstructive pulmonary disease  (ISO)
colon cancer  (IEP)
congestive heart failure  (ISO)
Contrast-Induced Nephropathy  (ISO)
coronary artery disease  (ISO)
Crohn's disease  (ISO)
depressive disorder  (ISO)
Diabetic Foot  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
disease by infectious agent  (ISO)
disease of metabolism  (ISO)
Drug Hypersensitivity Syndrome  (ISO)
end stage renal disease  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (IDA,ISO)
Experimental Liver Cirrhosis  (IEP)
familial hyperlipidemia  (IEP)
Fever of Unknown Origin  (ISO)
gastrointestinal stromal tumor  (ISO)
genetic disease  (ISO)
heart disease  (ISO)
hepatocellular carcinoma  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Human Influenza  (ISO)
hypertension  (IEP,ISO)
hypertensive retinopathy  (ISO)
Hypertriglyceridemia  (ISO)
Hypoxia  (ISO)
Inflammation  (IEP,ISO)
inflammatory bowel disease  (ISO)
intermediate coronary syndrome  (ISO)
interstitial cystitis  (ISO)
interstitial nephritis  (ISO)
Intestinal Reperfusion Injury  (IEP)
iron deficiency anemia  (IEP)
juvenile rheumatoid arthritis  (ISO)
Kawasaki disease  (ISO)
kidney failure  (ISO)
Kuhnt-Junius degeneration  (ISO)
Left Ventricular Hypertrophy  (ISO)
leishmaniasis  (ISO)
liver cirrhosis  (ISO)
low tension glaucoma  (ISO)
Lung Neoplasms  (ISO)
lupus nephritis  (ISO)
Lymphatic Metastasis  (ISO)
macular degeneration  (ISO)
malaria  (ISO)
mastoiditis  (ISO)
meningitis  (ISO)
Metabolic Syndrome  (ISO)
mevalonic aciduria  (ISO)
middle cerebral artery infarction  (ISO)
mouth disease  (IEP)
Mycoplasma pneumoniae pneumonia  (ISO)
myocardial infarction  (IEP,ISO)
Myocardial Ischemia  (IEP,ISO)
Myocardial Reperfusion Injury  (IEP)
myocarditis  (ISO)
non-arteritic anterior ischemic optic neuropathy  (ISO)
obesity  (IEP,ISO)
obstructive sleep apnea  (ISO)
otitis externa  (ISO)
otitis media  (ISO)
overactive bladder syndrome  (ISO)
parathyroid carcinoma  (ISO)
Parkinson's disease  (ISO)
Pasteurellaceae Infections  (ISO)
pelvic inflammatory disease  (ISO)
periodontitis  (ISO)
pharyngoconjunctival fever  (ISO)
Pneumococcal Pneumonia  (ISO)
pneumonia  (ISO)
polymyalgia rheumatica  (ISO)
Polypoidal Choroidal Vasculopathy  (ISO)
Postoperative Atrial Fibrillation  (ISO)
Pseudomonas Infections  (IEP,ISO)
psoriasis  (ISO)
pulmonary hypertension  (ISO)
pulmonary sarcoidosis  (ISO)
pulmonary tuberculosis  (ISO)
pyelonephritis  (IEP)
renal cell carcinoma  (ISO)
Renal Colic  (ISO)
renal fibrosis  (ISO)
renal hypertension  (IEP)
retinal vein occlusion  (ISO)
rheumatoid arthritis  (IDA,ISO)
secondary hyperparathyroidism  (ISO)
Sepsis  (IEP,ISO)
Sjogren's syndrome  (ISO)
Spinal Cord Injuries  (IDA)
status epilepticus  (IEP)
Stevens-Johnson syndrome  (ISO)
systemic lupus erythematosus  (ISO)
temporal arteritis  (ISO)
thrombosis  (ISO)
Tubulointerstitial Nephritis and Uveitis  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
urticaria  (ISO)
uveal melanoma  (ISO)
vestibular neuronitis  (ISO)
visceral leishmaniasis  (ISO)
withdrawal disorder  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP)
(1->4)-beta-D-glucan  (ISO)
(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoic acid  (ISO)
(R)-lipoic acid  (EXP)
(R,R,R)-alpha-tocopherol  (ISO)
1,1-dichloroethene  (EXP)
1-O-palmitoyl-2-O-(5-oxovaleryl)-sn-glycero-3-phosphocholine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (EXP)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
7,12-dimethyltetraphene  (ISO)
abacavir  (ISO)
acalabrutinib  (ISO)
acetamide  (EXP)
acetic acid  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
alclofenac  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
amiodarone  (ISO)
amlodipine  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (EXP)
atorvastatin calcium  (EXP,ISO)
benidipine  (EXP)
benzbromarone  (ISO)
benzene  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzylpenicillin  (ISO)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP)
bisphenol F  (EXP)
bivalirudin  (ISO)
boron atom  (EXP)
Botulinum toxin type A  (EXP)
Bromperidol  (ISO)
cadmium atom  (ISO)
calcitriol  (ISO)
candesartan  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
carnosine  (EXP,ISO)
carvedilol  (EXP,ISO)
celecoxib  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibric acid  (EXP)
clozapine  (ISO)
cobalt dichloride  (EXP)
cocaine  (ISO)
colesevelam hydrochloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (EXP,ISO)
curcumin  (EXP,ISO)
cyanocob(III)alamin  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (EXP,ISO)
cyproconazole  (ISO)
cyproterone acetate  (ISO)
D-penicillamine  (ISO)
daidzein  (ISO)
delta-tocotrienol  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (EXP)
desogestrel  (ISO)
dexamethasone  (ISO)
Diallyl sulfide  (EXP)
diarsenic trioxide  (EXP)
diclofenac  (EXP,ISO)
dienogest  (ISO)
disodium selenite  (ISO)
doxazosin  (ISO)
elemental boron  (EXP)
endosulfan  (EXP)
epoxiconazole  (ISO)
eptifibatide  (ISO)
erythromycin A  (ISO)
ethanol  (EXP,ISO)
ezetimibe  (ISO)
fenofibrate  (ISO)
flucloxacillin  (ISO)
flunitrazepam  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fosfomycin  (ISO)
fructose  (EXP,ISO)
fumonisin B1  (ISO)
furan  (EXP)
gamma-tocopherol  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP,ISO)
geraniol  (EXP)
gestodene  (ISO)
ginsenoside Re  (EXP)
gossypin  (EXP)
heparin  (ISO)
indinavir  (ISO)
indometacin  (EXP)
iron(2+) sulfate (anhydrous)  (ISO)
iron(III) citrate  (ISO)
isoprenaline  (EXP)
ivermectin  (ISO)
kaempferol  (ISO)
L-arginine  (EXP)
L-ascorbic acid  (ISO)
lead diacetate  (EXP)
lead(0)  (ISO)
levonorgestrel  (ISO)
lipoic acid  (EXP)
lipopolysaccharide  (EXP,ISO)
lovastatin  (EXP)
lupeol  (EXP)
medroxyprogesterone acetate  (ISO)
Mesaconitine  (EXP)
metformin  (EXP,ISO)
mevalonic acid  (ISO)
milrinone  (ISO)
mono(2-ethyl-5-hydroxyhexyl) phthalate  (ISO)
mono(2-ethyl-5-oxohexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
morphine  (ISO)
myricitrin  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
neoechinulin A  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nicotinic acid  (ISO)
nitrofen  (EXP)
nitrogen dioxide  (ISO)
nomegestrol  (ISO)
nomegestrol acetate  (ISO)
Nonidet P-40  (ISO)
norgestimate  (ISO)
O-methyleugenol  (ISO)
obeticholic acid  (ISO)
oleic acid  (ISO)
olmesartan  (ISO)
Olmesartan medoxomil  (EXP)
ozone  (EXP)
p-menthan-3-ol  (EXP)
pamidronate  (ISO)
paracetamol  (EXP,ISO)
Pentoxifylline  (ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
phosphatidylcholine  (ISO)
pioglitazone  (EXP,ISO)
pirinixic acid  (ISO)
pravastatin  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (ISO)
pterostilbene  (ISO)
quercetin  (ISO)
resveratrol  (EXP,ISO)
riboflavin  (ISO)
rifampicin  (ISO)
rifamycin SV  (ISO)
rivastigmine  (EXP)
rosmarinic acid  (EXP)
rosuvastatin calcium  (ISO)
rotenone  (ISO)
salvianolic acid B  (EXP,ISO)
SB 203580  (ISO)
simvastatin  (ISO)
sodium arsenite  (EXP,ISO)
sodium nitrite  (EXP)
sterigmatocystin  (ISO)
streptozocin  (ISO)
superoxide  (EXP)
telmisartan  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thalidomide  (ISO)
thioacetamide  (EXP)
tibolone  (ISO)
titanium dioxide  (ISO)
TMC-120A  (ISO)
triadimefon  (ISO)
trichloroethene  (EXP)
Triptolide  (EXP,ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vitamin E  (ISO)
withaferin A  (EXP)
wortmannin  (ISO)
zaragozic acid A  (EXP,ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
extracellular space  (IBA,IDA,IEA,ISO)
filopodium  (IDA)
growth cone  (IDA)
membrane  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Postoperative atrial fibrillation is not correlated to C-reactive protein. Ahlsson AJ, etal., Ann Thorac Surg. 2007 Apr;83(4):1332-7.
2. Hospitalised patients with Influenza A (H1N1) in the Royal Hospital, Oman: Experience of a tertiary care hospital, July-December 2009. Al-Lawati J, etal., Sultan Qaboos Univ Med J. 2010 Dec;10(3):326-34. Epub 2010 Nov 14.
3. Plasma oxidative and inflammatory markers in patients with idiopathic Parkinson's disease. Andican G, etal., Acta Neurol Belg. 2012 Feb 9.
4. The value of C-reactive protein determination in patients with renal colic to decide urgent urinary diversion. Angulo JC, etal., Urology. 2010 Aug;76(2):301-6. Epub 2010 Mar 5.
5. The effectiveness of Echinacea extract or composite glucosamine, chondroitin and methyl sulfonyl methane supplements on acute and chronic rheumatoid arthritis rat model. Arafa NM, etal., Toxicol Ind Health. 2011 Dec 15.
6. Atheroma plaque, metabolic syndrome and inflammation in patients with psoriasis. Arias-Santiago S, etal., Eur J Dermatol. 2012 Apr 16.
7. C-reactive protein (CRP): An important diagnostic and prognostic tool in nursing-home-associated pneumonia. Arinzon Z, etal., Arch Gerontol Geriatr. 2011 Mar 23.
8. Long-term outcome of tumor necrosis factor alpha antagonist's treatment in pediatric Crohn's disease. Assa A, etal., J Crohns Colitis. 2012 Apr 4.
9. Association between C-reactive protein and generalized anxiety disorder in stable coronary heart disease patients. Bankier B, etal., Eur Heart J. 2008 Sep;29(18):2212-7. doi: 10.1093/eurheartj/ehn326. Epub 2008 Jul 4.
10. Prolonged C1 inhibitor administration improves local healing of burn wounds and reduces myocardial inflammation in a rat burn wound model. Begieneman MP, etal., J Burn Care Res. 2012 Jul;33(4):544-51.
11. The effects of melatonin on burn-induced inflammatory responses and coagulation disorders in rats. Bekyarova G, etal., Methods Find Exp Clin Pharmacol. 2010 Jun;32(5):299-303.
12. Promotion of beta-amyloid production by C-reactive protein and its implications in the early pathogenesis of Alzheimer's disease. Bi BT, etal., Neurochem Int. 2012 Feb;60(3):257-66. Epub 2011 Dec 19.
13. Platelet count, mean platelet volume and smoking status in stable chronic obstructive pulmonary disease. Biljak VR, etal., Platelets. 2011 Apr 20.
14. Relationship between inflammatory markers, oxidant-antioxidant status and intima-media thickness in prepubertal children with juvenile idiopathic arthritis. Breda L, etal., Clin Res Cardiol. 2012 Aug 11.
15. Effects of topical indomethacin, bromfenac and nepafenac on lipopolysaccharide-induced ocular inflammation. Bucolo C, etal., J Pharm Pharmacol. 2014 Jul;66(7):954-60. doi: 10.1111/jphp.12224. Epub 2014 Feb 12.
16. Synergistic effects of aminoglycosides and fosfomycin on Pseudomonas aeruginosa in vitro and biofilm infections in a rat model. Cai Y, etal., J Antimicrob Chemother. 2009 Sep;64(3):563-6. Epub 2009 Jun 26.
17. Accuracy of white blood cell count, C-reactive protein, interleukin-6 and tumor necrosis factor alpha for diagnosing late neonatal sepsis. Caldas JP, etal., J Pediatr (Rio J). 2008 Nov-Dec;84(6):536-42. doi: doi:10.2223/JPED.1838.
18. Lack of effect of a single injection of human C-reactive protein on murine lupus or nephrotoxic nephritis. Carlucci F, etal., Arthritis Rheum. 2010 Jan;62(1):245-9.
19. Early proinflammatory cytokines and C-reactive protein trends as predictors of outcome in invasive Aspergillosis. Chai L, etal., J Infect Dis. 2010 Nov 1;202(9):1454-62. doi: 10.1086/656527.
20. Significant elevation of plasma pentraxin 3 in patients with pelvic inflammatory disease. Chang CC, etal., Clin Chem Lab Med. 2011 Oct;49(10):1655-60. doi: 10.1515/CCLM.2011.650. Epub 2011 Jun 17.
21. Augmented nitric oxide generation in neutrophils: oxidative and pro-inflammatory implications in hypertension. Chatterjee M, etal., Free Radic Res. 2009 Dec;43(12):1195-204.
22. [Promoting effect of granulocyto-colony stimulating factor on neovascularization in rats with myocardial infarction]. Chen T, etal., Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2010 Oct;24(10):1239-43.
23. Molecular and clinical characteristics of adenoviral infections in Taiwanese children in 2004-2005. Cheng CC, etal., Eur J Pediatr. 2008 Jun;167(6):633-40. Epub 2007 Sep 18.
24. Inflammatory gene polymorphisms and susceptibility to kawasaki disease and its arterial sequelae. Cheung YF, etal., Pediatrics. 2008 Sep;122(3):e608-14. doi: 10.1542/peds.2008-0646. Epub 2008 Aug 18.
25. Mastoiditis diagnosed by clinical symptoms and imaging studies in children: disease spectrum and evolving diagnostic challenges. Chien JH, etal., J Microbiol Immunol Infect. 2012 Oct;45(5):377-81. doi: 10.1016/j.jmii.2011.12.008. Epub 2012 May 9.
26. Malignant otitis externa: an Australian case series. Chin R, etal., Surgeon. 2012 Oct;10(5):273-7. doi: 10.1016/j.surge.2011.09.004. Epub 2011 Oct 26.
27. C-reactive protein elevation in patients with atrial arrhythmias: inflammatory mechanisms and persistence of atrial fibrillation. Chung MK, etal., Circulation. 2001 Dec 11;104(24):2886-91.
28. Elevation of serum c-reactive protein in patients with OAB and IC/BPS implies chronic inflammation in the urinary bladder. Chung SD, etal., Neurourol Urodyn. 2011 Mar;30(3):417-20. doi: 10.1002/nau.20938. Epub 2011 Jan 31.
29. NP1 regulates neuronal activity-dependent accumulation of BAX in mitochondria and mitochondrial dynamics. Clayton KB, etal., J Neurosci. 2012 Jan 25;32(4):1453-66.
30. The association of low-grade systemic inflammation with hypertensive retinopathy. Coban E, etal., Clin Exp Hypertens. 2010;32(8):528-31. doi: 10.3109/10641963.2010.496519.
31. Inflammation reduces HDL protection against primary cardiac risk. Corsetti JP, etal., Eur J Clin Invest. 2010 Jun;40(6):483-9. doi: 10.1111/j.1365-2362.2010.02287.x. Epub 2010 Apr 14.
32. Role of thrombocytosis in diagnosis of giant cell arteritis and differentiation of arteritic from non-arteritic anterior ischemic optic neuropathy. Costello F, etal., Eur J Ophthalmol. 2004 May-Jun;14(3):245-57.
33. Complement activation in patients with COVID-19: A novel therapeutic target. Cugno M, etal., J Allergy Clin Immunol. 2020 May 14. pii: S0091-6749(20)30650-3. doi: 10.1016/j.jaci.2020.05.006.
34. [Assess the impact of concentrations of inflammatory markers IL-6, CRP in the presence of albuminuria in patients with type 2 diabetes]. Czyzewska J, etal., Pol Merkur Lekarski. 2012 Feb;32(188):98-102.
35. Exercise Training and Antioxidants: Effects on Rat Heart Tissue Exposed to Lead Acetate. Dabidi Roshan V, etal., Int J Toxicol. 2011 Mar 4.
36. C-reactive protein and atrial fibrillation in idiopathic dilated cardiomyopathy. Dai S, etal., Clin Cardiol. 2009 Sep;32(9):E45-50. doi: 10.1002/clc.20430.
37. Isolation and characterization of C-reactive protein and serum amyloid P component in the rat. de Beer FC, etal., Immunology. 1982 Jan;45(1):55-70.
38. Selection of Symptomatic Patients With Crohn's Disease for Abdominopelvic Computed Tomography: Role of Serum C-Reactive Protein. Desmond AN, etal., Can Assoc Radiol J. 2012 Mar 14.
39. Rat C-reactive protein activates the autologous complement system. Diaz Padilla N, etal., Immunology. 2003 Aug;109(4):564-71.
40. Retinal vein occlusion: C-reactive protein and arterial hypertension. Dodson PM and Shine B, Acta Ophthalmol (Copenh). 1984 Feb;62(1):123-30.
41. Iron deficiency and renal development in the newborn rat. Drake KA, etal., Pediatr Res. 2009 Dec;66(6):619-24.
42. Cytokine activation during attacks of the hyperimmunoglobulinemia D and periodic fever syndrome. Drenth JP, etal., Blood. 1995 Jun 15;85(12):3586-93.
43. Decreased autoantibody levels and enhanced survival of (NZB x NZW) F1 mice treated with C-reactive protein. Du Clos TW, etal., Clin Immunol Immunopathol. 1994 Jan;70(1):22-7.
44. Risk factors for recurrence of diabetic foot ulcers: prospective follow-up analysis of a Eurodiale subgroup. Dubsky M, etal., Int Wound J. 2012 Jun 19. doi: 10.1111/j.1742-481X.2012.01022.x.
45. Periodontitis in humans and non-human primates: oral-systemic linkage inducing acute phase proteins. Ebersole JL, etal., Ann Periodontol. 2002 Dec;7(1):102-11.
46. Correlation of oxidative stress and inflammatory markers with the severity of sickle cell nephropathy. Emokpae MA, etal., Ann Afr Med. 2010 Jul-Sep;9(3):141-6.
47. Risk factors for contrast induced nephropathy: A study among Italian patients. Evola S, etal., Indian Heart J. 2012 Sep-Oct;64(5):484-91. doi: 10.1016/j.ihj.2012.07.007. Epub 2012 Jul 27.
48. Role of quercetin and arginine in ameliorating nano zinc oxide-induced nephrotoxicity in rats. Faddah LM, etal., BMC Complement Altern Med. 2012 May 2;12:60.
49. Nitric oxide-induced expression of C-reactive protein in islet cells as a very early marker for islet stress in the rat pancreas. Fehsel K, etal., Nitric Oxide. 1997 Jun;1(3):254-62.
50. Complement factor H Y402H and C-reactive protein polymorphism and photodynamic therapy response in age-related macular degeneration. Feng X, etal., Ophthalmology. 2009 Oct;116(10):1908-12.e1. doi: 10.1016/j.ophtha.2009.03.011. Epub 2009 Aug 18.
51. Autoantibodies against C-reactive protein: clinical associations in systemic lupus erythematosus and primary antiphospholipid syndrome. Figueredo MA, etal., J Rheumatol. 2006 Oct;33(10):1980-6.
52. C-reactive protein is released in the coronary circulation and causes endothelial dysfunction in patients with acute coronary syndromes. Forte L, etal., Int J Cardiol. 2011 Oct 6;152(1):7-12. doi: 10.1016/j.ijcard.2011.05.062. Epub 2011 Jul 26.
53. Diagnostic utility of clinical laboratory data determinations for patients with the severe COVID-19. Gao Y, etal., J Med Virol. 2020 Jul;92(7):791-796. doi: 10.1002/jmv.25770. Epub 2020 Apr 10.
54. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
55. Effect of a high-fat diet on the hepatic expression of nuclear receptors and their target genes: relevance to drug disposition. Ghoneim RH, etal., Br J Nutr. 2015 Feb 14;113(3):507-16. doi: 10.1017/S0007114514003717. Epub 2015 Jan 23.
56. Human C-reactive protein increases cerebral infarct size after middle cerebral artery occlusion in adult rats. Gill R, etal., J Cereb Blood Flow Metab. 2004 Nov;24(11):1214-8.
57. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
58. C-reactive protein levels do not correlate with retinal artery occlusion but with atherosclerosis. Goldenberg-Cohen N, etal., Eye (Lond). 2009 Apr;23(4):785-90. doi: 10.1038/eye.2008.159. Epub 2008 Jun 6.
59. Serum biomarkers of aging in the Brown Norway rat. Gordon CJ, etal., Exp Gerontol. 2011 Nov;46(11):953-7. Epub 2011 Jul 28.
60. Adeno-associated virus-mediated human C-reactive protein gene delivery causes endothelial dysfunction and hypertension in rats. Guan H, etal., Clin Chem. 2009 Feb;55(2):274-84. doi: 10.1373/clinchem.2008.115857. Epub 2008 Dec 4.
61. Docosahexaenoic acid, but not eicosapentaenoic acid, reduces the early inflammatory response following compression spinal cord injury in the rat. Hall JC, etal., J Neurochem. 2012 Jun;121(5):738-50. doi: 10.1111/j.1471-4159.2012.07726.x. Epub 2012 Apr 12.
62. Inhibition of classical complement activation attenuates liver ischaemia and reperfusion injury in a rat model. Heijnen BH, etal., Clin Exp Immunol. 2006 Jan;143(1):15-23.
63. Blood plasma inflammation markers during epileptogenesis in post-status epilepticus rat model for temporal lobe epilepsy. Holtman L, etal., Epilepsia. 2013 Apr;54(4):589-95. doi: 10.1111/epi.12112. Epub 2013 Feb 8.
64. Using IL-2R/lymphocytes for predicting the clinical progression of patients with COVID-19. Hou H, etal., Clin Exp Immunol. 2020 Jul;201(1):76-84. doi: 10.1111/cei.13450. Epub 2020 May 15.
65. Systemic inflammation and innate immune response in patients with previous anterior uveitis. Huhtinen M, etal., Br J Ophthalmol. 2002 Apr;86(4):412-7.
66. C-reactive protein and uric Acid levels in patients with psoriasis. Isha, etal., Indian J Clin Biochem. 2011 Jul;26(3):309-11. doi: 10.1007/s12291-011-0132-4. Epub 2011 May 4.
67. [The relationship between inflammatory mediators and pulmonary hypertension in patients with chronic obstructive pulmonary disease]. Jiang YW, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2011 Dec;34(12):904-8.
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74. Lipid peroxidation and erythrocyte antioxidant enzymes in patients with Behcet's disease. Kose K, etal., Tohoku J Exp Med. 2002 May;197(1):9-16.
75. Value of procalcitonin, C-reactive protein, and neopterin in exacerbations of chronic obstructive pulmonary disease. Lacoma A, etal., Int J Chron Obstruct Pulmon Dis. 2011;6:157-69. Epub 2011 Feb 28.
76. Acute-phase proteins and serum immunoglobulins in ankylosing spondylitis. Laurent MR and Panayi GS, Ann Rheum Dis. 1983 Oct;42(5):524-8.
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90. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
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111. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
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117. GOA pipeline RGD automated data pipeline
118. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
119. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
120. Comprehensive gene review and curation RGD comprehensive gene curation
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125. Inhibition of the binding of low density lipoproteins to liver membrane receptors by rat serum phosphorylcholine binding protein. Saxena U, etal., Biochem Biophys Res Commun. 1986 Nov 26;141(1):151-7.
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137. High prevalence of autoantibodies to C-reactive protein in patients with chronic hepatitis C infection: association with liver fibrosis and portal inflammation. Sjowall C, etal., Hum Immunol. 2012 Apr;73(4):382-8. Epub 2012 Feb 1.
138. Association of posttraumatic stress disorder with low-grade elevation of C-reactive protein: evidence from the general population. Spitzer C, etal., J Psychiatr Res. 2010 Jan;44(1):15-21. doi: 10.1016/j.jpsychires.2009.06.002. Epub 2009 Jul 22.
139. Validation of CRP as prognostic marker for renal cell carcinoma in a large series of patients. Steffens S, etal., BMC Cancer. 2012 Sep 8;12(1):399.
140. Elevated C-reactive protein levels may be a predictor of persistent unfavourable symptoms in patients with mild traumatic brain injury: a preliminary study. Su SH, etal., Brain Behav Immun. 2014 May;38:111-7. doi: 10.1016/j.bbi.2014.01.009. Epub 2014 Jan 21.
141. The effects of C-reactive protein, interleukin-6, and tumor necrosis factor-alpha in rat allograft adventitial inflammation and allograft arteriosclerosis. Sun H, etal., Transplant Proc. 2009 Nov;41(9):3909-12.
142. C-reactive protein predicts response to infliximab in patients with chronic sarcoidosis. Sweiss NJ, etal., Sarcoidosis Vasc Diffuse Lung Dis. 2010 Jul;27(1):49-56.
143. Association between baseline levels of C-reactive protein (CRP) and a dinucleotide repeat polymorphism in the intron of the CRP gene. Szalai AJ, etal., Genes Immun. 2002 Feb;3(1):14-9.
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Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81387,694,062 - 87,695,978 (+)NCBIGRCr8
mRatBN7.21385,135,384 - 85,175,178 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1385,124,977 - 85,175,178 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1387,664,967 - 87,666,915 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01389,065,246 - 89,067,190 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01386,249,976 - 86,251,928 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01391,080,448 - 91,081,358 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1391,054,974 - 91,093,713 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01395,599,418 - 95,600,328 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41388,702,243 - 88,703,153 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11388,891,058 - 88,892,928 (+)NCBI
Celera1384,770,843 - 84,771,753 (+)NCBICelera
Cytogenetic Map13q24NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381159,712,289 - 159,714,589 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1159,712,289 - 159,714,589 (-)EnsemblGRCh38hg38GRCh38
GRCh371159,682,079 - 159,684,379 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361157,948,703 - 157,951,003 (-)NCBINCBI36Build 36hg18NCBI36
Build 341156,495,152 - 156,497,452NCBI
Celera1132,750,525 - 132,752,817 (-)NCBICelera
Cytogenetic Map1q23.2NCBI
HuRef1131,038,539 - 131,040,831 (-)NCBIHuRef
CHM1_11161,076,594 - 161,078,894 (-)NCBICHM1_1
T2T-CHM13v2.01158,849,333 - 158,851,633 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391172,525,623 - 172,527,533 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1172,525,622 - 172,660,598 (+)EnsemblGRCm39 Ensembl
GRCm381172,698,056 - 172,699,966 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1172,698,055 - 172,833,031 (+)EnsemblGRCm38mm10GRCm38
MGSCv371174,628,187 - 174,630,097 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361174,534,741 - 174,536,635 (+)NCBIMGSCv36mm8
Celera1175,548,254 - 175,550,142 (+)NCBICelera
Cytogenetic Map1H3NCBI
cM Map180.13NCBI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v2190,140,428 - 90,143,900 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1189,880,463 - 89,883,937 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01135,062,102 - 135,064,402 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11138,858,353 - 138,860,652 (-)NCBIpanpan1.1PanPan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.13822,396,787 - 22,398,180 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3822,396,263 - 22,399,166 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3822,473,724 - 22,475,116 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03822,519,785 - 22,521,176 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3822,519,714 - 22,522,146 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13822,286,369 - 22,287,757 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03822,818,770 - 22,820,163 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03823,230,160 - 23,231,548 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_0244050585,866,551 - 5,870,192 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936740883,272 - 890,606 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936740885,855 - 888,854 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl490,793,350 - 90,805,218 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1490,793,361 - 90,801,020 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2498,764,964 - 98,772,727 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1204,232,262 - 4,235,826 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl204,232,913 - 4,235,377 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660383,340,251 - 3,342,511 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247941,531,571 - 1,533,804 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247941,531,555 - 1,533,804 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Crp
454 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:88
Count of miRNA genes:74
Interacting mature miRNAs:83
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
12879444Bp397Blood pressure QTL 397arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134504940490049404Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134551471990514719Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)135987440885581182Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)136906051986800898Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)136906051986800898Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)136906051986800898Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)137486211785581182Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1374862117101339893Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat
1302791Stl29Serum triglyceride level QTL 293.30.0011blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)138473078886800898Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21385,162,863 - 85,163,015 (+)MAPPERmRatBN7.2
Rnor_6.01391,081,476 - 91,081,627NCBIRnor6.0
Rnor_5.01395,600,446 - 95,600,597UniSTSRnor5.0
RGSC_v3.41388,703,271 - 88,703,422UniSTSRGSC3.4
Celera1384,771,871 - 84,772,022UniSTS
Cytogenetic Map13q24UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map14q11UniSTS
Cytogenetic Map13q27UniSTS
Cytogenetic Map13q24UniSTS
Cytogenetic Map20q11UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 13 13 13
Medium 2 2 30 14 18 14 2 2 11 10 9 10 2
Low 1 15 14 14 1 14 6 9 57 25 32 1 6
Below cutoff 26 6


Nucleotide Sequences
RefSeq Transcripts NM_017096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AY310153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY318961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY321318 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY321324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY325196 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY325218 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY325232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC091157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219098 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HH755429 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HI986631 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ438878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ438879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ438880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ438881 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ438882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ438883 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ438884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ438885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ438886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ438887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ438888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ438889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ438890 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ438891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ438892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ438893 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ438894 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ438895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ438896 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ438897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M83176 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000000058   ⟹   ENSRNOP00000000058
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1385,124,977 - 85,163,634 (+)Ensembl
Rnor_6.0 Ensembl1391,080,341 - 91,081,629 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000091089   ⟹   ENSRNOP00000074751
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1385,135,399 - 85,175,178 (+)Ensembl
Rnor_6.0 Ensembl1391,054,974 - 91,093,713 (+)Ensembl
RefSeq Acc Id: NM_017096   ⟹   NP_058792
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
GRCr81387,694,062 - 87,695,978 (+)NCBI
mRatBN7.21385,161,724 - 85,163,640 (+)NCBI
Rnor_6.01391,080,448 - 91,081,358 (+)NCBI
Rnor_5.01395,599,418 - 95,600,328 (+)NCBI
RGSC_v3.41388,702,243 - 88,703,153 (+)RGD
Celera1384,770,843 - 84,771,753 (+)RGD
Protein Sequences
Protein RefSeqs NP_058792 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40964 (Get FASTA)   NCBI Sequence Viewer  
  AAH91157 (Get FASTA)   NCBI Sequence Viewer  
  AAP78761 (Get FASTA)   NCBI Sequence Viewer  
  AAP85372 (Get FASTA)   NCBI Sequence Viewer  
  AAP86250 (Get FASTA)   NCBI Sequence Viewer  
  AAP86256 (Get FASTA)   NCBI Sequence Viewer  
  AAP92597 (Get FASTA)   NCBI Sequence Viewer  
  AAP92619 (Get FASTA)   NCBI Sequence Viewer  
  AAP92633 (Get FASTA)   NCBI Sequence Viewer  
  AFA37850 (Get FASTA)   NCBI Sequence Viewer  
  AFA37851 (Get FASTA)   NCBI Sequence Viewer  
  AFA37852 (Get FASTA)   NCBI Sequence Viewer  
  AFA37853 (Get FASTA)   NCBI Sequence Viewer  
  AFA37854 (Get FASTA)   NCBI Sequence Viewer  
  AFA37855 (Get FASTA)   NCBI Sequence Viewer  
  AFA37856 (Get FASTA)   NCBI Sequence Viewer  
  AFA37857 (Get FASTA)   NCBI Sequence Viewer  
  AFA37858 (Get FASTA)   NCBI Sequence Viewer  
  AFA37859 (Get FASTA)   NCBI Sequence Viewer  
  AFA37860 (Get FASTA)   NCBI Sequence Viewer  
  AFA37861 (Get FASTA)   NCBI Sequence Viewer  
  AFA37862 (Get FASTA)   NCBI Sequence Viewer  
  AFA37863 (Get FASTA)   NCBI Sequence Viewer  
  AFA37864 (Get FASTA)   NCBI Sequence Viewer  
  AFA37865 (Get FASTA)   NCBI Sequence Viewer  
  AFA37866 (Get FASTA)   NCBI Sequence Viewer  
  AFA37867 (Get FASTA)   NCBI Sequence Viewer  
  AFA37868 (Get FASTA)   NCBI Sequence Viewer  
  AFA37869 (Get FASTA)   NCBI Sequence Viewer  
  CBW53726 (Get FASTA)   NCBI Sequence Viewer  
  CBY88722 (Get FASTA)   NCBI Sequence Viewer  
  EDL94725 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000000058.4
GenBank Protein P48199 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058792   ⟸   NM_017096
- Peptide Label: precursor
- UniProtKB: Q5BK94 (UniProtKB/Swiss-Prot),   P48199 (UniProtKB/Swiss-Prot),   H6X2W5 (UniProtKB/TrEMBL),   H6X2V1 (UniProtKB/TrEMBL),   H6X2V8 (UniProtKB/TrEMBL),   H6X2W3 (UniProtKB/TrEMBL),   H6X2W4 (UniProtKB/TrEMBL),   H6X2X0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000000058   ⟸   ENSRNOT00000000058
RefSeq Acc Id: ENSRNOP00000074751   ⟸   ENSRNOT00000091089
Protein Domains
DUF1725   Pentraxin (PTX)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P48199-F1-model_v2 AlphaFold P48199 1-230 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13699031
Promoter ID:EPDNEW_R9556
Type:multiple initiation site
Description:C-reactive protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01391,080,367 - 91,080,427EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2411 AgrOrtholog
BioCyc Gene G2FUF-17296 BioCyc
Ensembl Genes ENSRNOG00000000053 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000000058.7 UniProtKB/TrEMBL
  ENSRNOT00000091089.2 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ConA-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF1725 UniProtKB/TrEMBL
  Pentaxin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pentraxin-related UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25419 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DUF1725 UniProtKB/TrEMBL
  Pentaxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Crp PhenoGen
PROSITE PTX_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000000053 RatGTEx
SMART PTX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49899 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CRP_RAT UniProtKB/Swiss-Prot
  Q63133_RAT UniProtKB/TrEMBL
UniProt Secondary A0A0G2K8V5 UniProtKB/TrEMBL
  Q5BK94 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-24 Crp  C-reactive protein  Crp  C-reactive protein, pentraxin-related  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Crp  C-reactive protein, pentraxin-related      Name updated 1299863 APPROVED
2002-06-10 Crp  C-reactive protein      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_protein glycoprotein that exists as a covalently-linked dimer 1298812