Crhbp (corticotropin releasing hormone binding protein)

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Gene: Crhbp (corticotropin releasing hormone binding protein) Rattus norvegicus

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Symbol:

Crhbp

Name:

corticotropin releasing hormone binding protein

RGD ID:

2403

Description:

Enables corticotropin-releasing hormone binding activity and peptide binding activity. Involved in several processes, including cellular response to cocaine; cellular response to estradiol stimulus; and cellular response to estrogen stimulus. Located in several cellular components, including axon; cytoplasmic vesicle; and perikaryon. Biomarker of depressive disorder; obesity; and temporal lobe epilepsy. Human ortholog(s) of this gene implicated in depressive disorder. Orthologous to human CRHBP (corticotropin releasing hormone binding protein); PARTICIPATES IN corticotropin-releasing hormone signaling pathway; INTERACTS WITH (S)-amphetamine; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

corticotropin releasing factor binding protein; corticotropin-releasing factor-binding protein; corticotropin-releasing hormone-binding protein; CRF-binding protein; CRF-BP; Crfbp; CRH-BP

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	28,427,139 - 28,439,446 (-)	NCBI		GRCr8
mRatBN7.2	2	26,692,403 - 26,704,710 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	26,692,403 - 26,704,710 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	33,730,555 - 33,742,870 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	31,830,779 - 31,843,094 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	26,646,279 - 26,658,547 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	25,141,471 - 25,153,334 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	25,141,471 - 25,153,334 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	44,299,507 - 44,311,225 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	25,801,371 - 25,813,457 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	25,721,739 - 25,733,799 (-)	NCBI
Celera	2	22,758,077 - 22,770,045 (-)	NCBI		Celera
Cytogenetic Map	2	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Cocaine-Related Disorders (ISO)

depressive disorder (IEP,ISO)

hepatocellular carcinoma (ISO)

Hermansky-Pudlak syndrome 2 (ISO)

Neurodevelopmental Disorders (ISO)

obesity (IEP)

temporal lobe epilepsy (IEP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(S)-amphetamine (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

2-palmitoylglycerol (ISO)

4,4'-sulfonyldiphenol (ISO)

5-fluorouracil (ISO)

6-propyl-2-thiouracil (EXP)

8-Br-cAMP (ISO)

Aflatoxin B2 alpha (ISO)

all-trans-retinoic acid (EXP)

ammonium chloride (EXP)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

bisphenol F (ISO)

casticin (ISO)

CGP 52608 (ISO)

chlorpyrifos (EXP)

clozapine (EXP)

cocaine (EXP)

copper atom (EXP)

copper(0) (EXP)

Dibutyl phosphate (ISO)

doxorubicin (ISO)

ethanol (ISO)

genistein (ISO)

haloperidol (EXP)

lipopolysaccharide (EXP,ISO)

mono(2-ethylhexyl) phthalate (ISO)

silicon dioxide (ISO)

Soman (EXP)

trichloroethene (EXP)

triclosan (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

behavioral response to ethanol (IEA,ISO,ISS)

cellular response to calcium ion (ISO,ISS)

cellular response to cAMP (ISO,ISS)

cellular response to cocaine (IDA)

cellular response to estradiol stimulus (IDA,IEA,ISO)

cellular response to estrogen stimulus (IDA,IEA,ISO)

cellular response to gonadotropin-releasing hormone (ISO,ISS)

cellular response to immobilization stress (IDA)

cellular response to potassium ion (IEA,ISO,ISS)

cellular response to tumor necrosis factor (IEA,ISO,ISS)

cellular response to xenobiotic stimulus (ISO,ISS)

female pregnancy (IEA,ISO)

hormone metabolic process (IEP,ISO)

hormone-mediated signaling pathway (IBA,IEA,ISO,ISS)

inflammatory response (IEA,ISO,ISS)

maternal aggressive behavior (ISO,ISS)

negative regulation of corticotropin secretion (IBA,IDA,IEA,ISO)

negative regulation of corticotropin-releasing hormone receptor activity (ISO,ISS)

regulated exocytosis (IEA,ISO,ISS)

regulation of cellular response to stress (IEA,ISO)

regulation of corticotropin secretion (ISO,ISS)

regulation of NMDA receptor activity (ISO,ISS)

synaptic transmission, dopaminergic (IEP,ISO,ISS)

Cellular Component

axon terminus (IDA)

dendrite (IDA)

dense core granule (IDA)

endoplasmic reticulum (ISO,ISS)

extracellular space (IBA,IDA,IEA,ISO)

Golgi apparatus (ISO,ISS)

microtubule (IDA)

multivesicular body (IDA)

nucleus (ISO,ISS)

perikaryon (IDA)

secondary lysosome (IDA)

secretory granule (IEA,ISO,ISS)

varicosity (IDA)

Molecular Function

corticotropin-releasing hormone binding (IBA,IDA,IEA,IPI,ISO)

peptide binding (IDA,IPI)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

corticotropin-releasing hormone signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	The corticotropin-releasing hormone binding protein is associated with major depression in a population from Northern Sweden.	Claes S, etal., Biol Psychiatry 2003 Nov 1;54(9):867-72.
2.	Isolation and characterization of the rat corticotropin-releasing hormone (CRH)-binding protein gene: transcriptional regulation by cyclic adenosine monophosphate and CRH.	Cortright DN, etal., Endocrinology 1997 May;138(5):2098-108.
3.	A single amino acid serves as an affinity switch between the receptor and the binding protein of corticotropin-releasing factor: implications for the design of agonists and antagonists.	Eckart K, etal., Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11142-7.
4.	Effects of chronic cocaine exposure on corticotropin-releasing hormone binding protein in the central nucleus of the amygdala and bed nucleus of the stria terminalis.	Erb S, etal., Neuroscience. 2004;123(4):1003-9.
5.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
7.	The effects of acute stress on the regulation of central and basolateral amygdala CRF-binding protein gene expression.	Herringa RJ, etal., Brain Res Mol Brain Res 2004 Nov 24;131(1-2):17-25.
8.	The molecular mechanisms underlying the regulation of the biological activity of corticotropin-releasing hormone receptors: implications for physiology and pathophysiology.	Hillhouse EW and Grammatopoulos DK, Endocr Rev. 2006 May;27(3):260-86. Epub 2006 Feb 16.
9.	Three-amino acid motifs of urocortin II and III determine their CRF receptor subtype selectivity.	Jahn O, etal., Neuropharmacology. 2004 Aug;47(2):233-42.
10.	The binding protein of corticotropin-releasing factor: Ligand-binding site and subunit structure.	Jahn O, etal., Proc Natl Acad Sci U S A 2002 Sep 17;99(19):12055-60.
11.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
12.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
13.	Icariin attenuates chronic mild stress-induced dysregulation of the LHPA stress circuit in rats.	Pan Y, etal., Psychoneuroendocrinology. 2010 Feb;35(2):272-83. Epub 2009 Jul 23.
14.	Ultrastructural localization of the corticotropin-releasing factor-binding protein in rat brain and pituitary.	Peto CA, etal., J Comp Neurol. 1999 Oct 18;413(2):241-54.
15.	Cloning and characterization of the cDNAs for human and rat corticotropin releasing factor-binding proteins.	Potter E, etal., Nature 1991 Jan 31;349(6308):423-6.
16.	GOA pipeline	RGD automated data pipeline
17.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
18.	Amygdala-kindled seizures increase the expression of corticotropin-releasing factor (CRF) and CRF-binding protein in GABAergic interneurons of the dentate hilus.	Smith MA, etal., Brain Res. 1997 Jan 16;745(1-2):248-56.
19.	Corticotropin-releasing hormone-binding protein in brain and pituitary of food-deprived obese (fa/fa) Zucker rats.	Timofeeva E, etal., Am J Physiol. 1999 Dec;277(6 Pt 2):R1749-59.
20.	Estrogen receptor (ER)-mediated transcriptional regulation of the human corticotropin-releasing hormone-binding protein promoter: differential effects of ERalpha and ERbeta.	van de Stolpe A, etal., Mol Endocrinol. 2004 Dec;18(12):2908-23. Epub 2004 Sep 2.
21.	Corticotropin-releasing factor binding protein within the ventral tegmental area is expressed in a subset of dopaminergic neurons.	Wang HL and Morales M, J Comp Neurol. 2008 Jul 20;509(3):302-18. doi: 10.1002/cne.21751.

Additional References at PubMed

PMID:7556876	PMID:12895416	PMID:13150566	PMID:15976007	PMID:17437087	PMID:18234674	PMID:18559919	PMID:18929624	PMID:21039637	PMID:21624661	PMID:24766650	PMID:26503565
PMID:27035969

Genomics

Comparative Map Data

Crhbp
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	28,427,139 - 28,439,446 (-)	NCBI		GRCr8
mRatBN7.2	2	26,692,403 - 26,704,710 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	26,692,403 - 26,704,710 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	33,730,555 - 33,742,870 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	31,830,779 - 31,843,094 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	26,646,279 - 26,658,547 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	25,141,471 - 25,153,334 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	25,141,471 - 25,153,334 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	44,299,507 - 44,311,225 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	25,801,371 - 25,813,457 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	25,721,739 - 25,733,799 (-)	NCBI
Celera	2	22,758,077 - 22,770,045 (-)	NCBI		Celera
Cytogenetic Map	2	q12	NCBI

CRHBP
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	76,953,045 - 76,981,159 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	76,953,045 - 76,981,158 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	76,248,870 - 76,265,296 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	76,284,436 - 76,301,055 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	76,284,435 - 76,301,054	NCBI
Celera	5	72,143,194 - 72,159,812 (+)	NCBI		Celera
Cytogenetic Map	5	q13.3	NCBI
HuRef	5	71,455,341 - 71,471,960 (+)	NCBI		HuRef
CHM1_1	5	75,681,815 - 75,698,436 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	77,434,877 - 77,462,968 (+)	NCBI		T2T-CHM13v2.0

Crhbp
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	95,567,884 - 95,581,339 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	95,567,879 - 95,581,432 (-)	Ensembl		GRCm39 Ensembl
GRCm38	13	95,431,376 - 95,444,831 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	95,431,371 - 95,444,924 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	96,201,331 - 96,214,786 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	96,532,075 - 96,545,471 (-)	NCBI		MGSCv36	mm8
Celera	13	99,051,989 - 99,065,285 (-)	NCBI		Celera
Cytogenetic Map	13	D1	NCBI
cM Map	13	49.5	NCBI

Crhbp
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955425	23,953,912 - 23,966,352 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955425	23,953,957 - 23,966,207 (-)	NCBI	ChiLan1.0	ChiLan1.0

CRHBP
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	38,323,975 - 38,341,995 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	36,477,602 - 36,495,622 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	38,327,305 - 38,343,901 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	38,852,934 - 38,869,529 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	38,845,925 - 38,869,549 (-)	Ensembl	panpan1.1		panPan2

CRHBP
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	3	29,726,316 - 29,737,748 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	3	29,705,031 - 29,758,111 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	3	30,965,624 - 30,977,333 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	3	29,645,525 - 29,657,242 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	3	29,645,521 - 29,657,131 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	3	29,582,245 - 29,593,950 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	3	29,562,941 - 29,574,639 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	3	29,932,261 - 29,943,976 (-)	NCBI		UU_Cfam_GSD_1.0

Crhbp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	190,780,826 - 190,794,463 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936549	64,866 - 78,272 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936549	64,866 - 78,272 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CRHBP
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	85,816,816 - 85,831,179 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	85,814,399 - 85,830,598 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	87,431,375 - 87,447,099 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CRHBP
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	4	71,203,335 - 71,223,179 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	4	71,205,932 - 71,223,172 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666049	20,043,907 - 20,061,809 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Crhbp
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624869	1,412,499 - 1,423,932 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624869	1,412,541 - 1,423,891 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Crhbp
106 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	80
Count of miRNA genes:	67
Interacting mature miRNAs:	74
Transcripts:	ENSRNOT00000024191
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10755430	Coatc6	Coat color QTL 6		0.02576	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	2	11591100	56591100	Rat
7387318	Stl32	Serum triglyceride level QTL 32	3.2	0.0003	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	2	22384627	67384627	Rat
631682	Bp115	Blood pressure QTL 115	4.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	1	37410502	Rat
10755499	Bp389	Blood pressure QTL 389	2.61		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	18960362	228801039	Rat
738010	Lnnr3	Liver neoplastic nodule remodeling QTL 3	2.94		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	2	1	41244106	Rat
1358917	Cm42	Cardiac mass QTL 42	2.82		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	203928301	Rat
731167	Glom4	Glomerulus QTL 4	2.4	0.0082	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	2	20304672	65304672	Rat
1358913	Cm41	Cardiac mass QTL 41	2.73		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	203928301	Rat
738012	Anxrr3	Anxiety related response QTL 3	3.8		exploratory behavior trait (VT:0010471)	percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)	2	9023519	54023519	Rat
1302794	Stl27	Serum triglyceride level QTL 27	4.4	0.0001	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	2	25413423	143657569	Rat
10402051	Gdil2	Gastrointestinal dilation QTL 2			enteric ganglion morphology trait (VT:0001045)	length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)	2	24903853	74786777	Rat
1358901	Cm38	Cardiac mass QTL 38	2		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	157142209	Rat
1600379	Mcs18	Mammary carcinoma susceptibility QTL 18	2.6		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	2	7887772	42804738	Rat
1358899	Kidm23	Kidney mass QTL 23	3.88		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
1358908	Bw49	Body weight QTL 49	3.36		body mass (VT:0001259)	body weight (CMO:0000012)	2	25413652	157142078	Rat
1358910	Kidm27	Kidney mass QTL 27	5.77		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
61355	Bp36	Blood pressure QTL 36	2.9		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	2	5873687	102844969	Rat
2300168	Bmd47	Bone mineral density QTL 47	6.6	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	2	20662448	65662448	Rat
1358911	Kidm28	Kidney mass QTL 28	5.42		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
1358904	Cm39	Cardiac mass QTL 39	2.26		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	157142209	Rat
1578664	Bmd9	Bone mineral QTL density 9	5		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	2	11852062	49003364	Rat
1357990	Ael1	Aortic elastin QTL 1	3.1	0.00091	aorta elastin amount (VT:0003905)	aortic elastin	2	19076825	64076825	Rat
1358887	Bw50	Body weight QTL 50	2.39		body mass (VT:0001259)	body weight (CMO:0000012)	2	25413652	157142078	Rat
1358894	Kidm24	Kidney mass QTL 24	4.03		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
731184	Mamtr4	Mammary tumor resistance QTL 4		0.0003	mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	2	16491740	61491740	Rat

Markers in Region

D2Wox56

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	26,692,458 - 26,692,656 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	25,141,527 - 25,141,724	NCBI	Rnor6.0
Rnor_5.0	2	44,299,563 - 44,299,760	UniSTS	Rnor5.0
RGSC_v3.4	2	25,801,427 - 25,801,624	UniSTS	RGSC3.4
Celera	2	22,758,133 - 22,758,330	UniSTS
Cytogenetic Map	2	q12	UniSTS

RH132846

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	26,692,646 - 26,692,838 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	25,141,715 - 25,141,906	NCBI	Rnor6.0
Rnor_5.0	2	44,299,751 - 44,299,942	UniSTS	Rnor5.0
RGSC_v3.4	2	25,801,615 - 25,801,806	UniSTS	RGSC3.4
Celera	2	22,758,321 - 22,758,512	UniSTS
RH 3.4 Map	2	13.3	UniSTS
Cytogenetic Map	2	q12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
8	8	15	111	39	36	12	23	12	6	101	55	93	18	41	24

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_139183	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AH005524	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473955	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000024191 ⟹ ENSRNOP00000024191

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	26,692,403 - 26,704,710 (-)	Ensembl
Rnor_6.0 Ensembl	2	25,141,471 - 25,153,334 (-)	Ensembl

RefSeq Acc Id:

NM_139183 ⟹ NP_631922

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	28,427,139 - 28,439,446 (-)	NCBI
mRatBN7.2	2	26,692,403 - 26,704,710 (-)	NCBI
Rnor_6.0	2	25,141,471 - 25,153,334 (-)	NCBI
Rnor_5.0	2	44,299,507 - 44,311,225 (-)	NCBI
RGSC_v3.4	2	25,801,371 - 25,813,457 (-)	RGD
Celera	2	22,758,077 - 22,770,045 (-)	RGD

Sequence:

show sequence

AAAGAGACCCAGGAAAGGGACCCTAGCAGCTTCGAGTTCTCAGTGTGGGCGAAGGCGAGGGAAG
AAACGCCTAAGATCTCCGCAGCCGAGCTCACCAGCTGCAGACACAAGGCCAGCCATGTCACCGA
ACTTCAAACTCCAATGCCACTTCACTCTGATCCTCCTGACAGCTCTAAGGGGAGAGAGCCGCTA
CCTAGAGGTGCAAGAAGCCGCAGTCTACGACCCTTTCCTGCTTTTCAGCGCCAATTTGAAGCGG
AACCTGGCAGAGGAGCAGCCCTACCGACGGGCTCTGCGCTGCCTGGACATGCTGAGCCTCCCTG
GCCAGTTCACCTTCACCGCTGACCAGCCGCAGCTGCACTGCGCCGCCTTCTTCATCGGCGAGCC
GGAGGAGTTCATCACCATCCACTTTGACCTGGTCTCCATCGACTGCCAGGGTGGGGATTTCCTG
AAGGTATTTGATGGTTGGATCCTTAAGGGGGAGAAGTTCCCAAGTTCTCAGGATCACCCTCTGC
CCACCAGGGAGAGGTACACAGATTTCTGTGAGAGCGGTCTCACCAGAAGGAGTGTTACATCTTC
CCAGAATGTGGCCATGGTCTTCTTCCGGGTCCATGAACCAGGAAATGGATTCACGATAACCATA
AAGACAGACCCCAACCTCTTCCCTTGCAATATCATCTCTCAGACTCCGAGTGGAAGATTTACTT
TGGTGGTTCCATACCAGCACCAAAACTGCAGCTTTTCCATCATTTATCCGGTGACCATCAAAAT
CTCTGACCTCGCCCTGGGACACCTGCATGGCCTTCAGTTGAAGAAACCTGCGGCTGGCTGTGGT
GGAACTGGAGACTTTGTGGAGCTGCTGGGAGGAACTGGACTGGACACCTCCAAGATGATGCTCT
TAGTGGACCTGTGTTACCCCTTTCATGGCCCTGCCCAGATGAAAATTAGCTGCGACAATGCTGT
GGTGAGGATGGTCTCCAGTGGAAAACACATGAACCGTGTGACTTTTGAGTATCGTCAGCTGGAA
CCACTCGAGCTGGAAACCTCGACCAGAAACAGCATCCCGGAGTACTGCTTGTCTAGTCTTTGAA
TGACCAGCTTCAGTGACTGGCATGCCGTTAGCCCAGTGAGTTCTCCACAGTTATTTTGGACGGA
GTGAAAAGCCTTCCAGTCAGTATTCCAGGCTTTGAAAACCTGCACACATGACTTCCAATTTCGC
TTCCTTTTGTTATAATGTATCAACGAGCAGAAGGCAGATAACAGGTGCCTGTTGGAAATGCTTG
GCCATTTTGGTGTGCTGCAGACAAGAACTGGTGAAACAAGGGTCCAGCAAGTGAGGAAGAGAGC
TGTGTGGCAAGGGCAGGTGCTCCAAAGAGAAAGAAATGGCAGCACTCACCGTTTCATGGCATAA
TAATAATAATAATAATAATAATAATAATAATAATAATAAAAGTCTTGAGTATACCAAAGGAATT
GTATCTGTTATTTTTACTTCATACTTCTGTTTACAAATTGTAGCTATCCGTTATTAATTGGTAG
TACTTGTTTTTTAAACAACACTTTGTAGCATGGGAACAAAACCTCCTTTCTATTCATAAATCCA
AATGCAAATAAATGTATGCAGAATGTTGGCATCTTG

hide sequence

Protein Sequences


Protein RefSeqs	NP_631922	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB65241	(Get FASTA)	NCBI Sequence Viewer
	EDM10099	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000024191.3
GenBank Protein	P24388	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_631922 ⟸ NM_139183
- Peptide Label:	precursor
- UniProtKB:	P24388 (UniProtKB/Swiss-Prot), O35761 (UniProtKB/TrEMBL), F7EU31 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSPNFKLQCHFTLILLTALRGESRYLEVQEAAVYDPFLLFSANLKRNLAEEQPYRRALRCLDML SLPGQFTFTADQPQLHCAAFFIGEPEEFITIHFDLVSIDCQGGDFLKVFDGWILKGEKFPSSQD HPLPTRERYTDFCESGLTRRSVTSSQNVAMVFFRVHEPGNGFTITIKTDPNLFPCNIISQTPSG RFTLVVPYQHQNCSFSIIYPVTIKISDLALGHLHGLQLKKPAAGCGGTGDFVELLGGTGLDTSK MMLLVDLCYPFHGPAQMKISCDNAVVRMVSSGKHMNRVTFEYRQLEPLELETSTRNSIPEYCLS SL hide sequence

Ensembl Acc Id:

ENSRNOP00000024191 ⟸ ENSRNOT00000024191

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P24388-F1-model_v2	AlphaFold	P24388	1-322	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2403	AgrOrtholog
BioCyc Gene	G2FUF-54807	BioCyc
Ensembl Genes	ENSRNOG00000017890	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000024191.5	UniProtKB/TrEMBL
Gene3D-CATH	2.60.120.290	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	CRF-bd	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Sperma_CUB_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:29625	UniProtKB/TrEMBL
NCBI Gene	29625	ENTREZGENE
PANTHER	CORTICOTROPIN-RELEASING FACTOR-BINDING PROTEIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR10278	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	CRF-BP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Crhbp	PhenoGen
PIRSF	CRF_bd	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000017890	RatGTEx
Superfamily-SCOP	SSF49854	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	CRHBP_RAT	UniProtKB/Swiss-Prot
	F7EU31	ENTREZGENE, UniProtKB/TrEMBL
	O35761	ENTREZGENE, UniProtKB/TrEMBL
	P24388	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2002-06-10	Crhbp	corticotropin releasing hormone binding protein			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_domains	the peptide sequence of amino acid residues 23-36 is the ligand binding site for CRH	625587
gene_physical_interaction	amino acid residues 23-36 are involved in binding to corticotropin releasing hormone	625587
gene_process	mediates the function of corticotropin-releasing hormone (CRH)	625587
gene_protein	37 kDa	625587

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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