Cpt1a (carnitine palmitoyltransferase 1A) - Rat Genome Database

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Gene: Cpt1a (carnitine palmitoyltransferase 1A) Rattus norvegicus
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Symbol: Cpt1a
Name: carnitine palmitoyltransferase 1A
RGD ID: 2396
Description: Enables carnitine O-palmitoyltransferase activity and identical protein binding activity. Involved in several processes, including fatty acid metabolic process; liver regeneration; and response to tetrachloromethane. Located in mitochondrial outer membrane. Biomarker of alcoholic hepatitis; end stage renal disease; metabolic dysfunction-associated steatohepatitis; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in carnitine palmitoyltransferase I deficiency and lipid metabolism disorder. Orthologous to human CPT1A (carnitine palmitoyltransferase 1A); PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; carnitine palmitoyltransferase I deficiency pathway; ethylmalonic encephalopathy pathway; INTERACTS WITH (+)-schisandrin B; (+)-taxifolin; (R)-carnitine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: carnitine O-palmitoyltransferase 1, liver isoform; carnitine O-palmitoyltransferase I, liver isoform; Carnitine palmitoyltransferase 1 alpha liver isoform; Carnitine palmitoyltransferase 1 alpha, liver isoform; Carnitine palmitoyltransferase 1, liver; carnitine palmitoyltransferase 1A liver; carnitine palmitoyltransferase 1a, liver; CPT I; CPT-Ia; CPT1-L; CPTI-L; succinyltransferase CPT1A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81209,993,881 - 210,056,329 (+)NCBIGRCr8
mRatBN7.21200,564,634 - 200,627,059 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1200,565,613 - 200,627,055 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1208,940,107 - 209,000,253 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01216,028,839 - 216,089,019 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01208,703,046 - 208,763,227 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01218,568,157 - 218,629,679 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1218,569,510 - 218,629,678 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01225,436,031 - 225,497,586 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41205,852,800 - 205,912,972 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11206,006,198 - 206,066,422 (+)NCBI
Celera1198,121,771 - 198,182,510 (+)NCBICelera
Cytogenetic Map1q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-beta-thujone  (ISO)
(+)-dexrazoxane  (ISO)
(+)-schisandrin B  (EXP)
(+)-taxifolin  (EXP)
(1->4)-beta-D-glucan  (ISO)
(R)-camphor  (ISO)
(R)-carnitine  (EXP,ISO)
(R)-linalyl acetate  (ISO)
(R)-lipoic acid  (EXP)
(R)-noradrenaline  (EXP)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-naringenin  (EXP)
1,2-dimethylhydrazine  (ISO)
1,4-benzoquinone  (ISO)
1,8-cineole  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-chloroethanol  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrylamide  (ISO)
Aescin  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
AICA ribonucleotide  (ISO)
aldehydo-D-glucose  (ISO)
Alisol B  (ISO)
all-trans-retinoic acid  (ISO)
alpha-linolenic acid  (ISO)
alpha-Zearalanol  (EXP)
AM-251  (ISO)
amiodarone  (EXP,ISO)
amitrole  (EXP)
amlexanox  (ISO)
angiotensin II  (EXP)
antirheumatic drug  (ISO)
arachidonic acid  (ISO)
aristolochic acids  (EXP)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (EXP)
atrazine  (ISO)
benzamides  (ISO)
benzbromarone  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
benzylpenicillin  (ISO)
berberine  (ISO)
beta-hexachlorocyclohexane  (ISO)
beta-lapachone  (ISO)
bezafibrate  (EXP,ISO)
bifenthrin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
buspirone  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
calciol  (EXP)
camphor  (ISO)
cannabidiol  (ISO)
cannabidiolic acid  (ISO)
cannabigerol  (ISO)
cannabigerolic acid  (ISO)
capsaicin  (EXP,ISO)
captan  (ISO)
carbon nanotube  (ISO)
carnitine  (EXP)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chloroethene  (ISO)
chlorothalonil  (ISO)
chlorpyrifos  (ISO)
cholesterol  (ISO)
cholic acid  (EXP)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (ISO)
Clofop  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
cordycepin  (ISO)
corn oil  (EXP,ISO)
corticosterone  (EXP)
cortisol  (ISO)
curcumin  (ISO)
cyclosporin A  (EXP)
cypermethrin  (ISO)
D-glucose  (ISO)
D-penicillamine  (EXP,ISO)
daidzein  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (EXP)
dehydroepiandrosterone sulfate  (EXP)
dexamethasone  (ISO)
Di-n-octyl phthalate  (ISO)
diallyl disulfide  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (EXP,ISO)
diethyl phthalate  (ISO)
difenoconazole  (ISO)
dihydroartemisinin  (EXP,ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
Diosbulbin B  (ISO)
dioscin  (EXP,ISO)
dioxygen  (ISO)
dipentyl phthalate  (EXP)
dobutamine  (EXP)
dopamine  (EXP)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
dronedarone  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
erythromycin A  (ISO)
ethanol  (EXP,ISO)
farnesol  (ISO)
fenamidone  (ISO)
fenofibrate  (EXP,ISO)
fipronil  (ISO)
flutamide  (EXP,ISO)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
formononetin  (ISO)
fructose  (EXP)
gadolinium atom  (ISO)
gadolinium trichloride  (EXP,ISO)
Ganoderic acid A  (ISO)
Gastrodin  (ISO)
gemfibrozil  (EXP)
genistein  (ISO)
gentamycin  (EXP)
Gingerenone A  (ISO)
glucagon  (ISO)
glucose  (ISO)
glutathione  (EXP)
glycine betaine  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
guggulsterone  (EXP,ISO)
GW 4064  (ISO)
GW 501516  (ISO)
GW 6471  (ISO)
GW 7647  (EXP,ISO)
Heptachlor epoxide  (ISO)
hexadecanoic acid  (EXP,ISO)
hydralazine  (EXP)
Ile(5)-angiotensin II  (EXP)
indometacin  (EXP,ISO)
inulin  (ISO)
isoniazide  (ISO)
isoprenaline  (EXP)
isosilybin  (ISO)
ivermectin  (ISO)
kaempferol  (EXP)
L-methionine  (ISO)
lamivudine  (ISO)
leflunomide  (EXP,ISO)
lenvatinib  (EXP)
levofloxacin  (EXP)
linalool  (ISO)
linalyl acetate  (ISO)
linoleic acid  (EXP)
lipoic acid  (EXP)
lipopolysaccharide  (EXP,ISO)
liraglutide  (ISO)
losartan  (EXP)
mangiferin  (EXP)
mercury dibromide  (ISO)
Mesaconitine  (EXP)
metformin  (EXP)
methapyrilene  (EXP,ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
metoprolol  (EXP)
miquelianin  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
monosodium L-glutamate  (EXP,ISO)
Muraglitazar  (EXP,ISO)
N(4)-hydroxycytidine  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-acetyl-L-cysteine  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
naringin  (ISO)
nefazodone  (EXP)
nickel dichloride  (EXP)
nicotinamide  (EXP)
nimesulide  (EXP)
NMN zwitterion  (ISO)
Nonylphenol  (EXP)
obeticholic acid  (EXP,ISO)
oleic acid  (EXP,ISO)
orlistat  (ISO)
osthole  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (ISO)
palmitoyl-CoA  (EXP)
paracetamol  (EXP)
paraquat  (EXP)
paricalcitol  (ISO)
penconazole  (ISO)
perflubutane  (ISO)
perfluorobutyric acid  (ISO)
perfluorodecanoic acid  (ISO)
perfluorododecanoic acid  (ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorohexanoic acid  (ISO)
perfluorononanoic acid  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoroundecanoic acid  (ISO)
permethrin  (ISO)
phenanthrene  (ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
phlorizin  (ISO)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
picrotoxin  (EXP)
pioglitazone  (ISO)
pirinixic acid  (EXP,ISO)
prednisone  (ISO)
procyanidin B1  (ISO)
procymidone  (ISO)
propiconazole  (EXP,ISO)
pterostilbene  (EXP)
puerarin  (ISO)
quercetin  (EXP,ISO)
rebaudioside A  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rimonabant  (EXP)
rosiglitazone  (EXP)
rotenone  (EXP,ISO)
sabinene  (ISO)
saroglitazar  (ISO)
SB 431542  (ISO)
sevoflurane  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (ISO)
Sodium oleate  (ISO)
sorafenib  (ISO)
spathulenol  (ISO)
starch  (ISO)
stavudine  (ISO)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (EXP,ISO)
sucrose  (ISO)
sulforaphane  (EXP)
sunitinib  (EXP)
tamoxifen  (ISO)
taurine  (EXP)
tectoridin  (ISO)
tectorigenin  (ISO)
Tesaglitazar  (EXP,ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP,ISO)
tetrahydropalmatine  (ISO)
tetrathiomolybdate(2-)  (EXP)
thiacloprid  (ISO)
thioacetamide  (EXP)
thiophanate-methyl  (ISO)
thiram  (ISO)
toosendanin  (ISO)
topotecan  (EXP)
triadimefon  (EXP)
tributyl phosphate  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
triphenyl phosphate  (EXP,ISO)
Triptolide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
Tris(2-ethylhexyl) phosphate  (ISO)
troglitazone  (EXP,ISO)
trovafloxacin  (EXP)
urea  (ISO)
valproic acid  (EXP,ISO)
vanadyl sulfate  (EXP)
vinclozolin  (EXP)
voriconazole  (EXP)
wortmannin  (EXP)
xanthohumol  (ISO)
zearalenone  (ISO)
zidovudine  (ISO)
zinc atom  (EXP,ISO)
zinc sulfate  (EXP)
zinc(0)  (EXP,ISO)
zingerone  (EXP)
ziram  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Modulation of the hepatic malonyl-CoA-carnitine palmitoyltransferase 1A partnership creates a metabolic switch allowing oxidation of de novo fatty acids1. Akkaoui M, etal., Biochem J. 2009 May 27;420(3):429-38.
2. The mitochondrial intermembrane loop region of rat carnitine palmitoyltransferase 1A is a major determinant of its malonyl-CoA sensitivity. Borthwick K, etal., J Biol Chem. 2006 Nov 3;281(44):32946-52. Epub 2006 Aug 14.
3. The liver isoform of carnitine palmitoyltransferase 1 is not targeted to the endoplasmic reticulum. Broadway NM, etal., Biochem J. 2003 Feb 15;370(Pt 1):223-31.
4. Niacin improves renal lipid metabolism and slows progression in chronic kidney disease. Cho KH, etal., Biochim Biophys Acta. 2010 Jan;1800(1):6-15. Epub 2009 Oct 28.
5. The N-terminal domain of rat liver carnitine palmitoyltransferase 1 contains an internal mitochondrial import signal and residues essential for folding of its C-terminal catalytic domain. Cohen I, etal., J Biol Chem. 2001 Feb 16;276(7):5403-11. Epub 2000 Nov 21.
6. Functional characterization of mitochondrial carnitine palmitoyltransferases I and II expressed in the yeast Pichia pastoris. de Vries Y, etal., Biochemistry 1997 Apr 29;36(17):5285-92.
7. Impaired expression of the peroxisome proliferator-activated receptor alpha during hepatitis C virus infection. Dharancy S, etal., Gastroenterology. 2005 Feb;128(2):334-42.
8. Xanthohumol ameliorates atherosclerotic plaque formation, hypercholesterolemia, and hepatic steatosis in ApoE-deficient mice. Doddapattar P, etal., Mol Nutr Food Res. 2013 Oct;57(10):1718-28. doi: 10.1002/mnfr.201200794. Epub 2013 May 3.
9. Cloning, sequencing, and expression of a cDNA encoding rat liver carnitine palmitoyltransferase I. Direct evidence that a single polypeptide is involved in inhibitor interaction and catalytic function. Esser V, etal., J Biol Chem 1993 Mar 15;268(8):5817-22.
10. Nonalcoholic hepatic steatosis in zucker diabetic rats: spontaneous evolution and effects of metformin and fenofibrate. Forcheron F, etal., Obesity (Silver Spring). 2009 Jul;17(7):1381-9. Epub 2009 Feb 19.
11. Topology of carnitine palmitoyltransferase I in the mitochondrial outer membrane. Fraser F, etal., Biochem J 1997 May 1;323 ( Pt 3):711-8.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
14. Comparison of the catalytic activities of three isozymes of carnitine palmitoyltransferase 1 expressed in COS7 cells. Hada T, etal., Appl Biochem Biotechnol. 2014 Feb;172(3):1486-96. doi: 10.1007/s12010-013-0619-y. Epub 2013 Nov 13.
15. Hepatoprotective effect of different combinations of 18α-and 18β-Glycyrrhizic acid against CCl4-induced liver injury in rats. Huo X, etal., Biomed Pharmacother. 2020 Feb;122:109354. doi: 10.1016/j.biopha.2019.109354. Epub 2019 Dec 30.
16. Molecular basis of hepatic carnitine palmitoyltransferase I deficiency. IJlst L, etal., J Clin Invest. 1998 Aug 1;102(3):527-31.
17. Self-association of transmembrane domain 2 (TM2), but not TM1, in carnitine palmitoyltransferase 1A: role of GXXXG(A) motifs. Jenei ZA, etal., J Biol Chem. 2009 Mar 13;284(11):6988-97. Epub 2009 Jan 9.
18. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
19. Phosphorylation of rat liver mitochondrial carnitine palmitoyltransferase-I: effect on the kinetic properties of the enzyme. Kerner J, etal., J Biol Chem. 2004 Sep 24;279(39):41104-13. Epub 2004 Jul 9.
20. In situ analysis of mTORC1/2 and cellular metabolism-related proteins in human Lymphangioleiomyomatosis. Krencz I, etal., Hum Pathol. 2018 Sep;79:199-207. doi: 10.1016/j.humpath.2018.05.018. Epub 2018 Jun 6.
21. PCSK9 inhibition as a novel therapeutic target for alcoholic liver disease. Lee JS, etal., Sci Rep. 2019 Nov 20;9(1):17167. doi: 10.1038/s41598-019-53603-6.
22. Mitochondrial carnitine palmitoyltransferase 1a (CPT1a) is part of an outer membrane fatty acid transfer complex. Lee K, etal., J Biol Chem. 2011 Jul 22;286(29):25655-62. doi: 10.1074/jbc.M111.228692. Epub 2011 May 26.
23. Therapeutic Effect of Gypenosides on Nonalcoholic Steatohepatitis via Regulating Hepatic Lipogenesis and Fatty Acid Oxidation. Li H, etal., Biol Pharm Bull. 2017;40(5):650-657. doi: 10.1248/bpb.b16-00942.
24. The PPARalpha/gamma dual agonist chiglitazar improves insulin resistance and dyslipidemia in MSG obese rats. Li PP, etal., Br J Pharmacol. 2006 Jul;148(5):610-8. Epub 2006 Jun 5.
25. Study on the protection of water extracts of Polygoni Multiflori Radix and Polygoni Multiflori Radix Praeparata against NAFLD and its mechanism. Lin L, etal., J Ethnopharmacol. 2020 Apr 24;252:112577. doi: 10.1016/j.jep.2020.112577. Epub 2020 Jan 15.
26. Modulation effects of black-vinegar-based supplement against a high-fat dietary habit: antiobesity/hypolipidemic, antioxidative, and energy-metabolism effects. Liu ME, etal., J Sci Food Agric. 2020 Apr;100(6):2380-2388. doi: 10.1002/jsfa.10246. Epub 2020 Feb 9.
27. Long-chain fatty acids regulate liver carnitine palmitoyltransferase I gene (L-CPT I) expression through a peroxisome-proliferator-activated receptor alpha (PPARalpha)-independent pathway. Louet JF, etal., Biochem J 2001 Feb 15;354(Pt 1):189-97.
28. The coactivator PGC-1 is involved in the regulation of the liver carnitine palmitoyltransferase I gene expression by cAMP in combination with HNF4 alpha and cAMP-response element-binding protein (CREB). Louet JF, etal., J Biol Chem 2002 Oct 11;277(41):37991-8000.
29. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
30. Structural model of carnitine palmitoyltransferase I based on the carnitine acetyltransferase crystal. Morillas M, etal., Biochem J. 2004 May 1;379(Pt 3):777-84.
31. Identification of conserved amino acid residues in rat liver carnitine palmitoyltransferase I critical for malonyl-CoA inhibition. Mutation of methionine 593 abolishes malonyl-CoA inhibition. Morillas M, etal., J Biol Chem. 2003 Mar 14;278(11):9058-63. Epub 2002 Dec 23.
32. Palmitate induces insulin resistance in H4IIEC3 hepatocytes through reactive oxygen species produced by mitochondria. Nakamura S, etal., J Biol Chem. 2009 May 29;284(22):14809-18. doi: 10.1074/jbc.M901488200. Epub 2009 Mar 30.
33. A single amino acid change (substitution of the conserved Glu-590 with alanine) in the C-terminal domain of rat liver carnitine palmitoyltransferase I increases its malonyl-CoA sensitivity close to that observed with the muscle isoform of the enzyme. Napal L, etal., J Biol Chem 2003 Sep 5;278(36):34084-9. Epub 2003 Jun 25.
34. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
35. Pig liver carnitine palmitoyltransferase. Chimera studies show that both the N- and C-terminal regions of the enzyme are important for the unusual high malonyl-CoA sensitivity. Nicot C, etal., J Biol Chem 2002 Mar 22;277(12):10044-9. Epub 2002 Jan 14.
36. Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production. Obici S, etal., Nat Med. 2003 Jun;9(6):756-61. Epub 2003 May 18.
37. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
38. The extreme C terminus of rat liver carnitine palmitoyltransferase I is not involved in malonyl-CoA sensitivity but in initial protein folding. Pan Y, etal., J Biol Chem. 2002 Dec 6;277(49):47184-9. Epub 2002 Sep 25.
39. Cloning and characterization of the promoter for the liver isoform of the rat carnitine palmitoyltransferase I (L-CPT I) gene. Park EA, etal., Biochem J 1998 Feb 15;330 ( Pt 1):217-24.
40. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
41. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
42. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
43. An environment-dependent structural switch underlies the regulation of carnitine palmitoyltransferase 1A. Rao JN, etal., J Biol Chem. 2011 Dec 9;286(49):42545-54. doi: 10.1074/jbc.M111.306951. Epub 2011 Oct 11.
44. GOA pipeline RGD automated data pipeline
45. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
46. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
47. Acute aflatoxin B1 - Induced hepatotoxicity alters gene expression and disrupts lipid and lipoprotein metabolism in rats. Rotimi OA, etal., Toxicol Rep. 2017 Jul 24;4:408-414. doi: 10.1016/j.toxrep.2017.07.006. eCollection 2017.
48. Adenovirus-mediated overexpression of liver carnitine palmitoyltransferase I in INS1E cells: effects on cell metabolism and insulin secretion. Rubi B, etal., Biochem J 2002 May 15;364(Pt 1):219-26.
49. Structural insight into function and regulation of carnitine palmitoyltransferase. Rufer AC, etal., Cell Mol Life Sci. 2009 Aug;66(15):2489-501. Epub 2009 May 9.
50. Carnitine Supplementation Attenuates Sunitinib-Induced Inhibition of AMP-Activated Protein Kinase Downstream Signals in Cardiac Tissues. Sayed-Ahmed MM, etal., Cardiovasc Toxicol. 2019 Aug;19(4):344-356. doi: 10.1007/s12012-018-9500-0.
51. Novel role of FATP1 in mitochondrial fatty acid oxidation in skeletal muscle cells. Sebastian D, etal., J Lipid Res. 2009 May 9.
52. A moderate increase in carnitine palmitoyltransferase 1a activity is sufficient to substantially reduce hepatic triglyceride levels. Stefanovic-Racic M, etal., Am J Physiol Endocrinol Metab. 2008 May;294(5):E969-77. Epub 2008 Mar 18.
53. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
54. Protective effect and mechanism of Qiwei Tiexie capsule on 3T3-L1 adipocytes cells and rats with nonalcoholic fatty liver disease by regulating LXRα, PPARγ, and NF-κB-iNOS-NO signaling pathways. Suolang PC, etal., J Ethnopharmacol. 2019 May 23;236:316-325. doi: 10.1016/j.jep.2019.03.006. Epub 2019 Mar 6.
55. Identification by mutagenesis of conserved arginine and glutamate residues in the C-terminal domain of rat liver carnitine palmitoyltransferase I that are important for catalytic activity and malonyl-CoA sensitivity. Treber M, etal., J Biol Chem. 2003 Mar 28;278(13):11145-9. Epub 2003 Jan 22.
56. Mouse trefoil factor 3 ameliorated high-fat-diet-induced hepatic steatosis via increasing peroxisome proliferator-activated receptor-α-mediated fatty acid oxidation. Wu X, etal., Am J Physiol Endocrinol Metab. 2019 Sep 1;317(3):E436-E445. doi: 10.1152/ajpendo.00454.2018. Epub 2019 Jun 18.
57. The preventive effect of phenolic-rich extracts from Chinese sumac fruits against nonalcoholic fatty liver disease in rats induced by a high-fat diet. Wu Z, etal., Food Funct. 2020 Jan 29;11(1):799-812. doi: 10.1039/c9fo02262g.
58. Dihydroartemisinin protects against alcoholic liver injury through alleviating hepatocyte steatosis in a farnesoid X receptor-dependent manner. Xu W, etal., Toxicol Appl Pharmacol. 2017 Jan 15;315:23-34. doi: 10.1016/j.taap.2016.12.001. Epub 2016 Dec 6.
59. WY14643 improves left ventricular myocardial mitochondrial and systolic functions in obese rats under chronic persistent hypoxia via the PPARα pathway. Yan J, etal., Life Sci. 2021 Feb 1;266:118888. doi: 10.1016/j.lfs.2020.118888. Epub 2020 Dec 10.
60. Therapeutic effect and autophagy regulation of myriocin in nonalcoholic steatohepatitis. Yang RX, etal., Lipids Health Dis. 2019 Oct 21;18(1):179. doi: 10.1186/s12944-019-1118-0.
61. Berberine Ameliorates High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Rats via Activation of SIRT3/AMPK/ACC Pathway. Zhang YP, etal., Curr Med Sci. 2019 Feb;39(1):37-43. doi: 10.1007/s11596-019-1997-3. Epub 2019 Mar 13.
Additional References at PubMed
PMID:7892212   PMID:8348957   PMID:8449947   PMID:8636126   PMID:8889548   PMID:11350182   PMID:11553629   PMID:12865426   PMID:12920182   PMID:14651853   PMID:15254779   PMID:15469941  
PMID:16177188   PMID:17062841   PMID:17239528   PMID:17650509   PMID:18385088   PMID:18614015   PMID:18706397   PMID:19073774   PMID:19946888   PMID:21492153   PMID:21541677   PMID:21909411  
PMID:21917985   PMID:22322067   PMID:22930490   PMID:22982985   PMID:23736540   PMID:23815800   PMID:26092479   PMID:26519879   PMID:27438137   PMID:27923787   PMID:28330968   PMID:28993954  
PMID:30605728   PMID:30764676   PMID:31405564  


Genomics

Comparative Map Data
Cpt1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81209,993,881 - 210,056,329 (+)NCBIGRCr8
mRatBN7.21200,564,634 - 200,627,059 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1200,565,613 - 200,627,055 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1208,940,107 - 209,000,253 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01216,028,839 - 216,089,019 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01208,703,046 - 208,763,227 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01218,568,157 - 218,629,679 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1218,569,510 - 218,629,678 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01225,436,031 - 225,497,586 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41205,852,800 - 205,912,972 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11206,006,198 - 206,066,422 (+)NCBI
Celera1198,121,771 - 198,182,510 (+)NCBICelera
Cytogenetic Map1q42NCBI
CPT1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381168,754,620 - 68,844,277 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1168,754,620 - 68,844,410 (-)EnsemblGRCh38hg38GRCh38
GRCh371168,522,088 - 68,609,384 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361168,278,664 - 68,365,881 (-)NCBINCBI36Build 36hg18NCBI36
Build 341168,281,656 - 68,365,881NCBI
Celera1165,858,303 - 65,945,748 (-)NCBICelera
Cytogenetic Map11q13.3NCBI
HuRef1164,858,312 - 64,945,656 (-)NCBIHuRef
CHM1_11168,405,839 - 68,493,144 (-)NCBICHM1_1
T2T-CHM13v2.01168,760,743 - 68,850,531 (-)NCBIT2T-CHM13v2.0
Cpt1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39193,372,328 - 3,435,735 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl193,372,334 - 3,435,733 (+)EnsemblGRCm39 Ensembl
GRCm38193,322,326 - 3,385,735 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl193,322,334 - 3,385,733 (+)EnsemblGRCm38mm10GRCm38
MGSCv37193,323,301 - 3,385,733 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36193,334,513 - 3,385,732 (+)NCBIMGSCv36mm8
Celera193,192,535 - 3,255,204 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map193.08NCBI
Cpt1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542217,109,256 - 17,159,838 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542217,105,887 - 17,159,696 (+)NCBIChiLan1.0ChiLan1.0
CPT1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2969,710,200 - 69,797,393 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11170,753,432 - 70,840,681 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01163,841,028 - 63,928,242 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11167,144,803 - 67,205,481 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1167,144,736 - 67,205,481 (-)Ensemblpanpan1.1panPan2
CPT1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11849,136,691 - 49,190,117 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1849,136,691 - 49,190,117 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1847,743,088 - 47,799,620 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01849,940,828 - 50,105,306 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1849,811,181 - 50,105,306 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11849,269,286 - 49,326,013 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01848,842,887 - 48,899,833 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01849,588,821 - 49,693,664 (+)NCBIUU_Cfam_GSD_1.0
Cpt1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049475,055,750 - 5,092,752 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365991,482,172 - 1,535,119 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365991,491,934 - 1,535,101 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CPT1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl24,233,099 - 4,293,911 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.124,250,642 - 4,293,914 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.222,844,854 - 2,874,141 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CPT1A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.115,704,275 - 5,784,077 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl15,730,853 - 5,784,337 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038102,984,159 - 103,065,332 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cpt1a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476718,109,008 - 18,161,639 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476718,109,011 - 18,161,378 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cpt1a
317 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:293
Count of miRNA genes:182
Interacting mature miRNAs:226
Transcripts:ENSRNOT00000019652
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1197814409242814409Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1197697768242697768Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
1302787Stl25Serum triglyceride level QTL 252.70.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1180359209210702199Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1172609619217609619Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1174133260219133260Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1558658Bw59Body weight QTL 593.50.0003body mass (VT:0001259)body weight (CMO:0000012)1178784622223784622Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1184550676229550676Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1171629477216629477Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1123556856242907031Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169537671214537671Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1171629477216629477Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1185145134221264292Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1183970203243914901Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1191019702246062233Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1173108781218108781Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1171629477216629477Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1181133855226133855Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1171629477216629477Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1197814409242814409Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2314011Gluco56Glucose level QTL 56blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1199773958202166723Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1193113876238113876Rat
1359018Hrtrt20Heart rate QTL 203.08heart pumping trait (VT:2000009)heart rate (CMO:0000002)1185356336202902618Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
1358292Cm37Cardiac mass QTL 376.28e-07heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1196248093241248093Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1197814409242814409Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1182623426219932796Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1171310381216310381Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1181759564214537555Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1176869060221869060Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1185356336231689108Rat
2292218Kidm35Kidney mass QTL 35kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1199368955224569684Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1169537671214537671Rat
1331790Bp201Blood pressure QTL 2013.127arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1198211513225126682Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1197697768238755659Rat
10059590Kidm44Kidney mass QTL 443.420.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1191033875236033875Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1196248093241248093Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1176550523221550523Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1188377360224054420Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
6480773Gluco64Glucose level QTL 645.09blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459200611765Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
634338Hcar4Hepatocarcinoma resistance QTL 44.6liver integrity trait (VT:0010547)liver tumorous lesion number to liver area ratio (CMO:0001210)1193422268214537671Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1183970203243914901Rat
6480783Insul19Insulin level QTL 194.33blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1197489281200611765Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1197670404242670404Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
6480780Insul18Insulin level QTL 184.11blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1189607473200611765Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1180359209218108781Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1181829673224569684Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1358191Ept10Estrogen-induced pituitary tumorigenesis QTL 103.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)1192825253243914732Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat

Markers in Region
D1Got189  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21200,611,501 - 200,611,765 (+)MAPPERmRatBN7.2
Rnor_6.01218,614,124 - 218,614,387NCBIRnor6.0
Rnor_5.01225,482,031 - 225,482,294UniSTSRnor5.0
RGSC_v3.41205,897,416 - 205,897,680RGDRGSC3.4
RGSC_v3.41205,897,417 - 205,897,680UniSTSRGSC3.4
RGSC_v3.11206,050,870 - 206,051,133RGD
Celera1198,166,955 - 198,167,218UniSTS
RH 3.4 Map11560.5UniSTS
RH 3.4 Map11560.5RGD
RH 2.0 Map11113.7RGD
Cytogenetic Map1q43UniSTS
AU049995  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21200,619,912 - 200,620,046 (+)MAPPERmRatBN7.2
Rnor_6.01218,622,535 - 218,622,666NCBIRnor6.0
Rnor_5.01225,490,442 - 225,490,573UniSTSRnor5.0
RGSC_v3.41205,905,828 - 205,905,959UniSTSRGSC3.4
Celera1198,175,366 - 198,175,497UniSTS
Cytogenetic Map1q43UniSTS
RH128242  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21200,626,749 - 200,626,933 (+)MAPPERmRatBN7.2
Rnor_6.01218,629,370 - 218,629,553NCBIRnor6.0
Rnor_5.01225,497,277 - 225,497,460UniSTSRnor5.0
RGSC_v3.41205,912,663 - 205,912,846UniSTSRGSC3.4
Celera1198,182,201 - 198,182,384UniSTS
RH 3.4 Map11522.4UniSTS
Cytogenetic Map1q43UniSTS
AA960192  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21200,626,820 - 200,626,929 (+)MAPPERmRatBN7.2
Rnor_6.01218,629,441 - 218,629,549NCBIRnor6.0
Rnor_5.01225,497,348 - 225,497,456UniSTSRnor5.0
RGSC_v3.41205,912,734 - 205,912,842UniSTSRGSC3.4
Celera1198,182,272 - 198,182,380UniSTS
Cytogenetic Map1q43UniSTS
PMC21059P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21200,625,770 - 200,626,398 (+)MAPPERmRatBN7.2
Rnor_6.01218,628,391 - 218,629,018NCBIRnor6.0
Rnor_5.01225,496,298 - 225,496,925UniSTSRnor5.0
RGSC_v3.41205,911,684 - 205,912,311UniSTSRGSC3.4
Celera1198,181,222 - 198,181,849UniSTS
Cytogenetic Map1q43UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000019652   ⟹   ENSRNOP00000019652
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1200,565,613 - 200,627,055 (+)Ensembl
Rnor_6.0 Ensembl1218,569,510 - 218,629,678 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000094391   ⟹   ENSRNOP00000080723
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1200,565,613 - 200,627,055 (+)Ensembl
RefSeq Acc Id: NM_031559   ⟹   NP_113747
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81209,996,160 - 210,056,329 (+)NCBI
mRatBN7.21200,566,888 - 200,627,059 (+)NCBI
Rnor_6.01218,569,510 - 218,629,679 (+)NCBI
Rnor_5.01225,436,031 - 225,497,586 (+)NCBI
RGSC_v3.41205,852,800 - 205,912,972 (+)RGD
Celera1198,121,771 - 198,182,510 (+)RGD
Sequence:
RefSeq Acc Id: XM_017588837   ⟹   XP_017444326
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81209,994,905 - 210,056,329 (+)NCBI
mRatBN7.21200,565,643 - 200,627,059 (+)NCBI
Rnor_6.01218,568,265 - 218,629,679 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039102321   ⟹   XP_038958249
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81209,993,881 - 210,056,329 (+)NCBI
mRatBN7.21200,564,634 - 200,627,059 (+)NCBI
RefSeq Acc Id: XM_063282351   ⟹   XP_063138421
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81209,994,304 - 210,056,329 (+)NCBI
RefSeq Acc Id: NP_113747   ⟸   NM_031559
- UniProtKB: P97780 (UniProtKB/Swiss-Prot),   Q6IMZ4 (UniProtKB/Swiss-Prot),   P32198 (UniProtKB/Swiss-Prot),   A6HYK3 (UniProtKB/TrEMBL),   A0A8I5ZQ86 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017444326   ⟸   XM_017588837
- Peptide Label: isoform X1
- UniProtKB: P97780 (UniProtKB/Swiss-Prot),   Q6IMZ4 (UniProtKB/Swiss-Prot),   P32198 (UniProtKB/Swiss-Prot),   A6HYK3 (UniProtKB/TrEMBL),   A0A8I5ZQ86 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000019652   ⟸   ENSRNOT00000019652
RefSeq Acc Id: XP_038958249   ⟸   XM_039102321
- Peptide Label: isoform X1
- UniProtKB: P97780 (UniProtKB/Swiss-Prot),   P32198 (UniProtKB/Swiss-Prot),   Q6IMZ4 (UniProtKB/Swiss-Prot),   A6HYK3 (UniProtKB/TrEMBL),   A0A8I5ZQ86 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000080723   ⟸   ENSRNOT00000094391
RefSeq Acc Id: XP_063138421   ⟸   XM_063282351
- Peptide Label: isoform X1
- UniProtKB: Q6IMZ4 (UniProtKB/Swiss-Prot),   P97780 (UniProtKB/Swiss-Prot),   P32198 (UniProtKB/Swiss-Prot),   A6HYK3 (UniProtKB/TrEMBL)
Protein Domains
Carnitine O-palmitoyltransferase N-terminal   Choline/carnitine acyltransferase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P32198-F1-model_v2 AlphaFold P32198 1-773 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690595
Promoter ID:EPDNEW_R1119
Type:single initiation site
Name:Cpt1a_1
Description:carnitine palmitoyltransferase 1A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01218,569,419 - 218,569,479EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2396 AgrOrtholog
BioCyc Gene G2FUF-56817 BioCyc
BioCyc Pathway PWY-6111 [mitochondrial L-carnitine shuttle] BioCyc
BioCyc Pathway Image PWY-6111 BioCyc
Ensembl Genes ENSRNOG00000014254 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055020936 UniProtKB/Swiss-Prot
  ENSRNOG00065030877 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000019652.4 UniProtKB/Swiss-Prot
  ENSRNOT00000094391.1 UniProtKB/TrEMBL
  ENSRNOT00055035746 UniProtKB/Swiss-Prot
  ENSRNOT00065053227 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.559.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.559.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.250.1760 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7105825 IMAGE-MGC_LOAD
InterPro Carn_acyl_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CAT-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cho/carn_acyl_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cho/carn_acyl_trans_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CPT_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25757 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:91635 IMAGE-MGC_LOAD
NCBI Gene 25757 ENTREZGENE
PANTHER CARNITINE O-PALMITOYLTRANSFERASE 1, LIVER ISOFORM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR22589 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Carn_acyltransf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CPT_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cpt1a PhenoGen
PROSITE ACYLTRANSF_C_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ACYLTRANSF_C_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014254 RatGTEx
  ENSRNOG00055020936 RatGTEx
  ENSRNOG00065030877 RatGTEx
Superfamily-SCOP CoA-dependent acyltransferases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZQ86 ENTREZGENE, UniProtKB/TrEMBL
  A6HYK3 ENTREZGENE, UniProtKB/TrEMBL
  B7ZDJ2_RAT UniProtKB/TrEMBL
  CPT1A_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  P97780 ENTREZGENE
  Q6IMZ4 ENTREZGENE
UniProt Secondary P97780 UniProtKB/Swiss-Prot
  Q6IMZ4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-01 Cpt1a  carnitine palmitoyltransferase 1A  Cpt1a  carnitine palmitoyltransferase 1a, liver  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Cpt1a  carnitine palmitoyltransferase 1a, liver    carnitine palmitoyltransferase 1, liver  Name updated 1299863 APPROVED
2002-06-10 Cpt1a  carnitine palmitoyltransferase 1      Name updated 70584 APPROVED
2001-10-23 Cpt1a  Carnitine palmitoyltransferase 1 alpha, liver isoform      Name updated to reflect Human and Mouse nomenclature 68913 WITHDRAWN
2001-10-23 Cpt1a  Carnitine palmitoyltransferase 1, liver      Name updated to reflect Human and Mouse nomenclature 68913 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localizes to the outer mitochondrial membrane 62419
gene_function converts long chain acyl-CoA to acylcarnitines 62419
gene_process regulates long chain fatty acid oxidation 62419
gene_process is necessary for proper insulin secretion 1298597
gene_regulation tightly regulated by its physiological inhibitor, malonyl-CoA 62419
gene_regulation expression in the liver is induced by long chain fatty acids and lipid-lowering compounds like clofibrate 628446
gene_transcript two cDNA isoforms exist, a hepatic and a muscle isoform 1298568