Cpd (carboxypeptidase D) - Rat Genome Database

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Gene: Cpd (carboxypeptidase D) Rattus norvegicus
Analyze
Symbol: Cpd
Name: carboxypeptidase D
RGD ID: 2393
Description: Enables protein phosphatase 2A binding activity. Involved in cellular response to interleukin-2. Located in nucleus; perinuclear region of cytoplasm; and trans-Golgi network. Orthologous to human CPD (carboxypeptidase D); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Carboxypeptidase D precursor; gp180; metallocarboxypeptidase D
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81062,121,681 - 62,185,638 (-)NCBIGRCr8
mRatBN7.21061,623,528 - 61,687,491 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1061,623,526 - 61,687,491 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1066,269,189 - 66,333,145 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01065,774,660 - 65,838,616 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01061,244,000 - 61,309,462 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01063,325,764 - 63,389,811 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1063,325,199 - 63,389,817 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01063,024,264 - 63,088,486 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41067,327,272 - 67,390,836 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11067,340,894 - 67,404,459 (+)NCBI
Celera1060,635,370 - 60,698,539 (-)NCBICelera
Cytogenetic Map10q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-trichloroethane  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphotericin B  (ISO)
benzo[a]pyrene  (ISO)
bilirubin IXalpha  (ISO)
bisphenol A  (EXP,ISO)
butan-1-ol  (ISO)
butanal  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
chloroprene  (EXP)
choline  (ISO)
clorgyline  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cyclosporin A  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dichlorine  (EXP)
dimethylarsinic acid  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
folic acid  (ISO)
FR900359  (ISO)
gamma-hexachlorocyclohexane  (EXP)
gentamycin  (EXP)
hydrogen cyanide  (ISO)
isobutanol  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
methapyrilene  (EXP)
methylmercury chloride  (ISO)
nitric oxide  (ISO)
ozone  (EXP)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium cyanide  (ISO)
procymidone  (EXP)
protein kinase inhibitor  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
testosterone  (EXP,ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. Characterization of a novel, cytokine-inducible carboxypeptidase D isoform in haematopoietic tumour cells. O'Malley PG, etal., Biochem J. 2005 Sep 15;390(Pt 3):665-73.
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Identification and nuclear localization of a novel prolactin and cytokine-responsive carboxypeptidase D. Too CK, etal., Endocrinology 2001 Mar;142(3):1357-67.
9. Cloning and sequence analysis of cDNA encoding rat carboxypeptidase D. Xin X, etal., DNA Cell Biol 1997 Jul;16(7):897-909.
Additional References at PubMed
PMID:19199708   PMID:19946888  


Genomics

Comparative Map Data
Cpd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81062,121,681 - 62,185,638 (-)NCBIGRCr8
mRatBN7.21061,623,528 - 61,687,491 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1061,623,526 - 61,687,491 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1066,269,189 - 66,333,145 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01065,774,660 - 65,838,616 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01061,244,000 - 61,309,462 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01063,325,764 - 63,389,811 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1063,325,199 - 63,389,817 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01063,024,264 - 63,088,486 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41067,327,272 - 67,390,836 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11067,340,894 - 67,404,459 (+)NCBI
Celera1060,635,370 - 60,698,539 (-)NCBICelera
Cytogenetic Map10q24NCBI
CPD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381730,378,927 - 30,469,989 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1730,378,927 - 30,469,989 (+)EnsemblGRCh38hg38GRCh38
GRCh371728,705,945 - 28,797,007 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361725,730,110 - 25,819,825 (+)NCBINCBI36Build 36hg18NCBI36
Build 341725,730,109 - 25,819,825NCBI
Celera1725,567,489 - 25,657,199 (+)NCBICelera
Cytogenetic Map17q11.2NCBI
HuRef1724,915,981 - 25,006,704 (+)NCBIHuRef
CHM1_11728,768,174 - 28,859,153 (+)NCBICHM1_1
T2T-CHM13v2.01731,323,558 - 31,414,615 (+)NCBIT2T-CHM13v2.0
Cpd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391176,668,034 - 76,737,834 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1176,669,250 - 76,737,844 (-)EnsemblGRCm39 Ensembl
GRCm381176,777,208 - 76,847,008 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1176,778,424 - 76,847,018 (-)EnsemblGRCm38mm10GRCm38
MGSCv371176,590,710 - 76,660,510 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361176,598,184 - 76,663,191 (-)NCBIMGSCv36mm8
Celera1184,282,160 - 84,345,782 (-)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1146.05NCBI
Cpd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554812,889,156 - 2,951,495 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554812,885,243 - 2,951,574 (-)NCBIChiLan1.0ChiLan1.0
CPD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21933,983,409 - 34,070,840 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11735,864,051 - 35,951,350 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01726,302,112 - 26,389,049 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11726,821,641 - 26,908,252 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1726,821,641 - 26,908,257 (-)Ensemblpanpan1.1panPan2
CPD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1944,388,147 - 44,469,775 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl944,388,219 - 44,466,074 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha943,539,778 - 43,621,450 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0945,207,559 - 45,287,811 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl945,207,487 - 45,286,195 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1943,987,222 - 44,067,108 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0944,274,017 - 44,354,213 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0944,358,343 - 44,440,254 (+)NCBIUU_Cfam_GSD_1.0
Cpd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560243,502,080 - 43,576,174 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365386,379,999 - 6,454,122 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365386,380,046 - 6,454,117 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CPD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1246,462,265 - 46,533,022 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11246,462,203 - 46,533,032 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21248,551,808 - 48,622,822 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CPD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11624,106,406 - 24,196,998 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1624,106,883 - 24,193,129 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660755,862,697 - 5,952,891 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cpd
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247862,866,059 - 2,941,879 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247862,866,020 - 2,940,615 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cpd
302 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:126
Count of miRNA genes:95
Interacting mature miRNAs:108
Transcripts:ENSRNOT00000005262
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
2306787Ean3Experimental allergic neuritis QTL 33.1nervous system integrity trait (VT:0010566)body weight loss (CMO:0001399)105379738566979128Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)106134527681714865Rat
61402Niddm3Non-insulin dependent diabetes mellitus QTL 34.58blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)106134541382564856Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)104944455181709989Rat
1331839Eae18bExperimental allergic encephalomyelitis QTL 18b5.80.03nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)106124830367785171Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104944455181709989Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
631526Bp76Blood pressure QTL 760.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106134541366743655Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)104287676679813922Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat

Markers in Region
D85391  
Rat AssemblyChrPosition (strand)SourceJBrowse
RGSC_v3.41067,390,633 - 67,390,766UniSTSRGSC3.4
Celera1060,635,440 - 60,635,534UniSTS
Cytogenetic Map10q26UniSTS
STS-H01467  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21061,620,069 - 61,620,200 (-)MAPPERmRatBN7.2
Rnor_6.01063,393,139 - 63,393,269NCBIRnor6.0
Rnor_5.01063,091,814 - 63,091,944UniSTSRnor5.0
RGSC_v3.41067,394,164 - 67,394,294UniSTSRGSC3.4
Celera1060,631,912 - 60,632,042UniSTS
Cytogenetic Map10q26UniSTS
AA960140  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera1060,632,010 - 60,632,110UniSTS
Cytogenetic Map10q26UniSTS
RH142190  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21061,623,567 - 61,623,718 (-)MAPPERmRatBN7.2
Rnor_6.01063,389,621 - 63,389,771NCBIRnor6.0
Rnor_5.01063,088,296 - 63,088,446UniSTSRnor5.0
RGSC_v3.41067,390,646 - 67,390,796UniSTSRGSC3.4
Celera1060,635,410 - 60,635,560UniSTS
Cytogenetic Map10q26UniSTS
BE120708  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21061,638,720 - 61,638,917 (-)MAPPERmRatBN7.2
Rnor_6.01063,374,281 - 63,374,477NCBIRnor6.0
Rnor_5.01063,072,956 - 63,073,152UniSTSRnor5.0
RGSC_v3.41067,375,448 - 67,375,644UniSTSRGSC3.4
Celera1060,650,562 - 60,650,758UniSTS
Cytogenetic Map10q26UniSTS
D85391  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21061,623,597 - 61,623,731 (-)MAPPERmRatBN7.2
Rnor_6.01063,389,608 - 63,389,741NCBIRnor6.0
Rnor_5.01063,088,283 - 63,088,416UniSTSRnor5.0
RGSC_v3.41067,390,633 - 67,390,766UniSTSRGSC3.4
Celera1060,635,440 - 60,635,573UniSTS
Cytogenetic Map10q26UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000005262   ⟹   ENSRNOP00000005262
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1061,623,526 - 61,687,491 (-)Ensembl
Rnor_6.0 Ensembl1063,325,199 - 63,389,817 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000084535   ⟹   ENSRNOP00000070498
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1063,327,555 - 63,389,813 (+)Ensembl
RefSeq Acc Id: NM_012836   ⟹   NP_036968
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81062,121,681 - 62,185,638 (-)NCBI
mRatBN7.21061,623,528 - 61,687,491 (-)NCBI
Rnor_6.01063,325,764 - 63,389,811 (+)NCBI
Rnor_5.01063,024,264 - 63,088,486 (+)NCBI
RGSC_v3.41067,327,272 - 67,390,836 (+)RGD
Celera1060,635,370 - 60,698,539 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036968 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB70456 (Get FASTA)   NCBI Sequence Viewer  
  AAF91481 (Get FASTA)   NCBI Sequence Viewer  
  EDM05269 (Get FASTA)   NCBI Sequence Viewer  
  EDM05270 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000005262.3
GenBank Protein Q9JHW1 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036968   ⟸   NM_012836
- Peptide Label: precursor
- UniProtKB: O35850 (UniProtKB/Swiss-Prot),   Q9JHW1 (UniProtKB/Swiss-Prot),   F1LPC6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070498   ⟸   ENSRNOT00000084535
Ensembl Acc Id: ENSRNOP00000005262   ⟸   ENSRNOT00000005262
Protein Domains
Peptidase M14   Peptidase M14 carboxypeptidase A

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JHW1-F1-model_v2 AlphaFold Q9JHW1 1-1378 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697434
Promoter ID:EPDNEW_R7959
Type:initiation region
Name:Cpd_1
Description:carboxypeptidase D
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01063,325,760 - 63,325,820EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2393 AgrOrtholog
BioCyc Gene G2FUF-24147 BioCyc
Ensembl Genes ENSRNOG00000003873 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005262.6 UniProtKB/TrEMBL
Gene3D-CATH Carboxypeptidase-like, regulatory domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Zn peptidases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CarboxyPept-like_regulatory UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  M14_CPD_II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  M14_CPD_III UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M14_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25306 UniProtKB/Swiss-Prot
NCBI Gene 25306 ENTREZGENE
PANTHER PROTEASE M14 CARBOXYPEPTIDASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11532:SF73 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CarboxypepD_reg UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cpd PhenoGen
PRINTS CRBOXYPTASEA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CARBOXYPEPT_ZN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CARBOXYPEPT_ZN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PEPTIDASE_M14 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000003873 RatGTEx
SMART Zn_pept UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49464 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Zn-dependent exopeptidases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6HGW4_RAT UniProtKB/TrEMBL
  A6HGW5_RAT UniProtKB/TrEMBL
  CBPD_RAT UniProtKB/Swiss-Prot
  F1LPC6 ENTREZGENE, UniProtKB/TrEMBL
  O35850 ENTREZGENE
  Q9JHW1 ENTREZGENE
UniProt Secondary O35850 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-11-06 Cpd  carboxypeptidase D    Carboxypeptidase D precursor  Name updated 625702 APPROVED
2002-06-10 Cpd  Carboxypeptidase D precursor      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in most tissues examined; highest expression in hippocampus, spinal cord, heart, colon, testis and ovaries 1298781
gene_process may participate in peptide processing in the secretory pathway 1298781
gene_product putative carboxypeptidase protein 1298781
gene_regulation CPD-N alternative transcript is induced by prolactin treatment in lymphoma cell lines 1298782
gene_transcript CPD-N alternative transcript is nuclear targeted 1298782