Abcc2 (ATP binding cassette subfamily C member 2) - Rat Genome Database

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Gene: Abcc2 (ATP binding cassette subfamily C member 2) Rattus norvegicus
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Symbol: Abcc2
Name: ATP binding cassette subfamily C member 2
RGD ID: 2366
Description: Enables ABC-type transporter activity; bilirubin transmembrane transporter activity; and protein domain specific binding activity. Involved in several processes, including carboxylic acid transport; cellular response to cytokine stimulus; and cellular response to dexamethasone stimulus. Located in brush border membrane and intracellular canaliculus. Used to study Dubin-Johnson syndrome; bilirubin metabolic disorder; cholestasis; end stage renal disease; and visual epilepsy. Biomarker of bilirubin metabolic disorder; cholestasis; liver disease (multiple); status epilepticus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in bilirubin metabolic disorder (multiple); carcinoma (multiple); leukemia (multiple); and liver disease (multiple). Orthologous to human ABCC2 (ATP binding cassette subfamily C member 2); PARTICIPATES IN docetaxel pharmacodynamics pathway; doxorubicin pharmacokinetics pathway; irinotecan pharmacodynamics pathway; INTERACTS WITH (+)-pilocarpine; (-)-epigallocatechin 3-gallate; (S)-colchicine.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: ATP-binding cassette sub-family C member 2; ATP-binding cassette, sub-family C (CFTR/MRP) member 2; ATP-binding cassette, sub-family C (CFTR/MRP), member 2; ATP-binding cassette, subfamily C (CFTR/MRP), member 2; calicular multispecific organic anion transporter; canalicular multidrug resistance protein; canalicular multispecific organic anion transporter; canalicular multispecific organic anion transporter 1; Cmoat; cMRP; cMrp2/cMoat canalicular apical conjugate export pump; mrp; Mrp2; multidrug resistance associated protein 2; multidrug resistance-associated protein 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Abcc2TR-   Abcc2em1Sage  
Genetic Models: WUN-Abcc2TR-/HsdRrrc SD-Abcc2em1Sage
Is Marker For: Strains:   WUN-Abcc2TR-/HsdRrrc  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81252,613,875 - 252,672,459 (+)NCBIGRCr8
mRatBN7.21242,664,657 - 242,723,239 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1242,664,657 - 242,723,238 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1250,813,581 - 250,872,198 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01257,510,469 - 257,569,198 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01250,163,726 - 250,222,340 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01263,554,426 - 263,612,556 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1263,554,453 - 263,613,252 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01270,999,832 - 271,057,750 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1238,483,399 - 238,539,595 (+)NCBICelera
Cytogenetic Map1q54NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(+/-)-Aegeline  (ISO)
(-)-epigallocatechin 3-gallate  (EXP)
(1->4)-beta-D-glucan  (ISO)
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
(RS)-coclaurine  (ISO)
(RS)-norcoclaurine  (ISO)
(S)-coclaurine  (ISO)
(S)-colchicine  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dichloroethane  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 17-glucosiduronic acid  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2',3'-dideoxyadenosine  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-acetamidofluorene  (ISO)
2-tert-butylhydroquinone  (EXP,ISO)
3',4',7-trihydroxyisoflavone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3-chloropropane-1,2-diol  (EXP)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (ISO)
4'-epidoxorubicin  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-hydroxynon-2-enal  (EXP,ISO)
5(6)-carboxy-2',7'-dichlorofluorescein  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
5-chloromethylfluorescein diacetate  (ISO)
5-fluorouracil  (ISO)
5-formyltetrahydrofolic acid  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
5-methoxypsoralen  (ISO)
6-bromoindirubin-3'-oxime  (ISO)
6-carboxyfluorescein  (ISO)
6-propyl-2-thiouracil  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
8-(4-chlorophenylthio)-cAMP  (ISO)
8-Br-cAMP  (EXP)
8-Epidiosbulbin E acetate  (ISO)
abietic acid  (EXP)
acadesine  (EXP)
acetamide  (EXP)
actinomycin D  (EXP,ISO)
aflatoxin B1  (ISO)
AICA ribonucleotide  (EXP)
aldehydo-D-glucose  (EXP)
alfacalcidol  (ISO)
all-trans-retinoic acid  (ISO)
allyl alcohol  (ISO)
alpha-amanitin  (ISO)
aluminium hydroxide  (EXP)
amiodarone  (EXP)
amphotericin B  (ISO)
ampicillin  (ISO)
angelicin  (EXP)
antimonite  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
atazanavir sulfate  (ISO)
atorvastatin calcium  (EXP,ISO)
ATP  (EXP,ISO)
azathioprine  (EXP,ISO)
aztreonam  (ISO)
benzbromarone  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzoylaconine  (ISO)
benzoylhypaconine  (ISO)
benzoylmesaconine  (ISO)
benzylpenicillin  (EXP,ISO)
beta-hexachlorocyclohexane  (ISO)
beta-naphthoflavone  (EXP,ISO)
bezafibrate  (ISO)
bilirubin IXalpha  (EXP)
biochanin A  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisdemethoxycurcumin  (ISO)
bisphenol A  (EXP,ISO)
Boldine  (EXP)
bortezomib  (ISO)
bosentan  (EXP,ISO)
bromfenac  (ISO)
bromosulfophthalein  (ISO)
bromuconazole  (EXP)
bucladesine  (EXP,ISO)
buspirone  (EXP)
buta-1,3-diene  (ISO)
butanal  (ISO)
butylated hydroxyanisole  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcein  (ISO)
calcein am  (EXP,ISO)
calcitriol  (EXP,ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
cannabidiol  (ISO)
captan  (ISO)
carbamazepine  (EXP,ISO)
carbon monoxide  (EXP)
carboplatin  (ISO)
carmustine  (ISO)
carvedilol  (ISO)
cefaloridine  (EXP)
cefalotin  (ISO)
celecoxib  (ISO)
cerivastatin  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (EXP,ISO)
chlorambucil  (ISO)
chlordecone  (ISO)
chlorogenic acid  (ISO)
chloroquine  (ISO)
chlorpromazine  (EXP,ISO)
chlorpyrifos  (ISO)
cholic acid  (ISO)
choline  (EXP,ISO)
chrysin  (ISO)
chrysophanol  (EXP)
ciprofloxacin  (ISO)
cisplatin  (EXP,ISO)
citalopram  (ISO)
clavulanic acid  (ISO)
clobazam  (EXP)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
clotrimazole  (ISO)
colforsin daropate hydrochloride  (ISO)
coniferyl aldehyde  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
curcumin  (ISO)
cyazofamid  (ISO)
cyclosporin A  (EXP,ISO)
cyproconazole  (EXP,ISO)
D-glucose  (EXP)
dapsone  (EXP)
daunorubicin  (ISO)
DDE  (ISO)
DDT  (ISO)
demethoxycurcumin  (ISO)
deoxycholic acid  (ISO)
desloratadine  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
Diallyl sulfide  (EXP)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (EXP,ISO)
dicrotophos  (ISO)
dieldrin  (ISO)
diethyl maleate  (ISO)
diethyl phthalate  (ISO)
Dimethyl phthalate  (ISO)
dimethylarsinic acid  (EXP)
Diosbulbin B  (ISO)
dioscin  (EXP)
diosgenin  (EXP)
dioxygen  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (EXP,ISO)
diquat  (ISO)
disodium selenite  (ISO)
doramapimod  (ISO)
dorsomorphin  (EXP,ISO)
dothiepin  (ISO)
doxorubicin  (EXP,ISO)
DPDPE  (EXP)
E3040  (ISO)
elemental selenium  (EXP,ISO)
emodin  (EXP,ISO)
endosulfan  (EXP,ISO)
enilconazole  (ISO)
epoxiconazole  (EXP)
Erucin  (ISO)
estrone 3-sulfate  (EXP,ISO)
etacrynic acid  (ISO)
ethambutol  (EXP)
ethoxyquin  (ISO)
etoposide  (ISO)
fenofibrate  (EXP)
Fexofenadine hydrochloride  (ISO)
Finrozole  (ISO)
fipronil  (EXP,ISO)
Fluo-3  (EXP)
fluoxetine  (ISO)
flutamide  (EXP)
fluvastatin  (EXP,ISO)
formononetin  (EXP,ISO)
fosinopril  (ISO)
FR900359  (ISO)
fructose  (EXP)
fulvestrant  (EXP,ISO)
furan  (EXP)
furosemide  (EXP,ISO)
fusidic acid  (EXP)
geneticin  (ISO)
genistein  (ISO)
gentamycin  (EXP)
geraniol  (EXP)
Ginkgolide A  (ISO)
ginkgolide B  (ISO)
ginsenoside Rb2  (EXP)
ginsenoside Re  (EXP,ISO)
ginsenoside Rg1  (EXP,ISO)
ginsenoside Rg2  (EXP)
glafenine  (EXP)
glucose  (EXP)
glutathione  (EXP,ISO)
glutathione disulfide  (EXP)
glyburide  (EXP,ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glycyrrhetinate  (EXP)
glycyrrhetinic acid  (EXP)
glyphosate  (ISO)
Goe 6976  (EXP,ISO)
gold atom  (ISO)
gold(0)  (ISO)
guggulsterone  (ISO)
GW 4064  (EXP,ISO)
hepoxilin A3  (ISO)
heptachlor  (ISO)
Heptachlor epoxide  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
Hypaconitine  (ISO)
icariside II  (ISO)
imipenem hydrate  (ISO)
indole-3-methanol  (EXP)
indometacin  (EXP,ISO)
inulin  (ISO)
irinotecan  (ISO)
iron(III) nitrilotriacetate  (ISO)
isoniazide  (EXP)
ivermectin  (ISO)
JTE-013  (EXP)
ketoconazole  (EXP,ISO)
kojic acid  (EXP)
KT 5720  (EXP,ISO)
L-ascorbic acid  (EXP,ISO)
L-cysteine  (EXP,ISO)
L-methionine  (EXP,ISO)
lead diacetate  (ISO)
leukotriene C4  (EXP,ISO)
levetiracetam  (EXP)
lipopolysaccharide  (EXP,ISO)
liquiritin  (ISO)
lithocholic acid  (EXP,ISO)
loperamide  (ISO)
lopinavir  (ISO)
loratadine  (ISO)
lovastatin  (EXP,ISO)
luteolin  (ISO)
LY294002  (ISO)
macitentan  (ISO)
manganese(II) chloride  (EXP)
Maprotiline  (EXP)
Meclizine  (ISO)
mercury atom  (EXP,ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (EXP,ISO)
Mesaconitine  (ISO)
metformin  (ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methotrexate  (EXP,ISO)
methoxsalen  (ISO)
methylarsonic acid  (EXP,ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
metiram  (ISO)
metronidazole  (ISO)
microcystin LF  (ISO)
microcystin RR  (ISO)
microcystin-LR  (ISO)
Midecamycin  (EXP,ISO)
mifepristone  (ISO)
MK 571  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (ISO)
mono(glucosyluronic acid)bilirubin  (EXP,ISO)
monosodium L-glutamate  (ISO)
montelukast  (ISO)
Muraglitazar  (EXP)
myricetin  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP,ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-Acetyl-S-(1,2-dichlorovinyl)-cysteine  (ISO)
N-hydroxy-PhIP  (ISO)
N-nitrosodiethylamine  (EXP)
N-Vinyl-2-pyrrolidone  (EXP)
nelfinavir  (ISO)
neomycin  (ISO)
nifedipine  (EXP)
nimesulide  (EXP)
nitric oxide  (EXP,ISO)
nitrofen  (EXP)
nitrogen dioxide  (ISO)
nocodazole  (ISO)
norgestimate  (ISO)
notoginsenoside R1  (EXP,ISO)
Nutlin-3  (ISO)
obeticholic acid  (EXP,ISO)
ochratoxin A  (EXP,ISO)
oleanolic acid  (ISO)
olmesartan  (ISO)
oltipraz  (EXP,ISO)
omeprazole  (ISO)
organoselenium compound  (ISO)
orphenadrine  (EXP)
ortho-Aminoazotoluene  (ISO)
oxaliplatin  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
pantoprazole  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
paroxetine  (ISO)
PCB138  (ISO)
pentachlorophenol  (ISO)
perfluorobutyric acid  (ISO)
perfluorodecanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
perhexiline  (EXP)
phalloidin  (EXP)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP,ISO)
phenol red  (EXP)
phenytoin  (EXP,ISO)
PhIP  (EXP,ISO)
phorbol 13-acetate 12-myristate  (EXP)
physcion  (EXP)
piperonyl butoxide  (ISO)
pirinixic acid  (EXP,ISO)
pitavastatin  (EXP,ISO)
pitavastatin(1-)  (EXP,ISO)
platinum  (ISO)
platinum(0)  (ISO)
pravastatin  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
probenecid  (EXP,ISO)
prochloraz  (EXP)
procymidone  (ISO)
progesterone  (ISO)
propane-1,2-diol  (ISO)
protein kinase inhibitor  (EXP)
prothioconazole  (ISO)
Prothioconazole-desthio  (ISO)
Prulifloxacin  (EXP)
psoralen  (EXP)
pyrazinecarboxamide  (EXP)
pyrrolidines  (EXP)
quercetin  (EXP,ISO)
reactive oxygen species  (EXP)
resveratrol  (EXP,ISO)
rifampicin  (EXP,ISO)
robinetin  (ISO)
rosuvastatin calcium  (EXP,ISO)
rotenone  (ISO)
rubitecan  (ISO)
S-(2,4-dinitrophenyl)glutathione  (EXP,ISO)
S-nitrosoglutathione  (EXP)
saquinavir  (ISO)
selenium atom  (EXP,ISO)
senecionine  (ISO)
sevoflurane  (EXP)
simvastatin  (EXP,ISO)
sincalide  (ISO)
sirolimus  (EXP)
sodium arsenate  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
sodium hydrogencarbonate  (EXP)
sodium selenide  (ISO)
sorafenib  (ISO)
soybean oil  (EXP)
spironolactone  (EXP)
stilbene oxide  (EXP)
streptozocin  (EXP,ISO)
succimer  (EXP,ISO)
sulfasalazine  (EXP)
sulfinpyrazone  (ISO)
sulforaphane  (EXP,ISO)
sunitinib  (EXP)
Sunset Yellow FCF  (ISO)
tamoxifen  (EXP,ISO)
Tanshinone I  (ISO)
tartrazine  (ISO)
taurine  (EXP)
tauro-beta-muricholic acid  (EXP)
taurochenodeoxycholic acid  (EXP)
taurocholic acid  (EXP,ISO)
taurolithocholic acid  (EXP)
tauroursodeoxycholic acid  (EXP,ISO)
tectorigenin  (ISO)
Temocaprilat  (EXP)
temozolomide  (ISO)
tert-butyl hydroperoxide  (EXP,ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
texas red  (EXP)
Theaflavin 3,3'-digallate  (ISO)
thiacloprid  (ISO)
thioacetamide  (EXP)
thiophanate-methyl  (ISO)
thyroxine  (EXP)
Thyroxine glucuronide  (EXP)
tiagabine  (EXP)
tianeptine  (EXP)
ticlopidine  (EXP,ISO)
titanium dioxide  (ISO)
tolvaptan  (ISO)
topiramate  (EXP)
topotecan  (ISO)
trans-piceid  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trimethylarsine oxide  (EXP)
triphenyl phosphate  (EXP,ISO)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tyrphostin AG 1478  (EXP)
uranium atom  (EXP)
urethane  (ISO)
ursodeoxycholic acid  (EXP,ISO)
vadimezan  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (EXP,ISO)
verapamil  (ISO)
vincaleukoblastine  (EXP,ISO)
vincristine  (ISO)
vitamin E  (EXP)
wortmannin  (EXP)
Y-27632  (ISO)
Yangonin  (ISO)
yohimbine  (ISO)
zearalenone  (ISO)
ziram  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
antibiotic metabolic process  (IMP)
benzylpenicillin metabolic process  (IMP)
bile acid and bile salt transport  (IEA,ISO,ISS)
bilirubin transport  (IEA,IMP,ISO)
canalicular bile acid transport  (IMP)
cellular response to dexamethasone stimulus  (IEP)
cellular response to interleukin-1  (IEP)
cellular response to interleukin-6  (IEP)
cellular response to lipopolysaccharide  (IEP)
cellular response to tumor necrosis factor  (IEP)
cellular response to xenobiotic stimulus  (IEP)
detoxification of mercury ion  (IMP)
female pregnancy  (IEP)
intracellular chloride ion homeostasis  (IDA)
leukotriene transport  (IEA,IMP,ISO)
mercury ion transport  (IMP)
negative regulation of gene expression  (IMP)
organic anion transport  (IMP,TAS)
prostaglandin transport  (IMP)
response to antineoplastic agent  (IEP)
response to arsenic-containing substance  (IEP)
response to estradiol  (IEP)
response to estrogen  (IDA,IEP)
response to glucagon  (IEP)
response to lipopolysaccharide  (IEP)
response to organic cyclic compound  (IEP)
response to oxidative stress  (IEP)
response to steroid hormone  (IEP)
response to xenobiotic stimulus  (IDA)
thyroid hormone transport  (IMP)
transepithelial transport  (IGI,IMP)
transmembrane transport  (IBA,IEA)
xenobiotic catabolic process  (IMP)
xenobiotic detoxification by transmembrane export across the plasma membrane  (IMP)
xenobiotic export from cell  (IEA,ISO)
xenobiotic transmembrane transport  (IEA,IMP,ISO)
xenobiotic transport across blood-brain barrier  (IGI,IMP)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Involvement of multidrug resistance-associated protein 2 (ABCC2/Mrp2) in biliary excretion of micafungin in rats. Abe F, etal., Life Sci. 2008 Aug 15;83(7-8):229-35. doi: 10.1016/j.lfs.2008.06.013. Epub 2008 Jul 1.
2. Involvement of Mrp2 (Abcc2) in biliary excretion of moxifloxacin and its metabolites in the isolated perfused rat liver. Ahmed S, etal., J Pharm Pharmacol. 2008 Jan;60(1):55-62. doi: 10.1211/jpp.60.1.0007.
3. Glucagon-like peptide 2 prevents down-regulation of intestinal multidrug resistance-associated protein 2 and P-glycoprotein in endotoxemic rats. Arana MR, etal., Toxicology. 2017 Sep 1;390:22-31. doi: 10.1016/j.tox.2017.08.007. Epub 2017 Aug 23.
4. Regulation of expression and activity of rat intestinal multidrug resistance-associated protein 2 by cholestatic estrogens. Arias A, etal., Drug Metab Dispos. 2009 Jun;37(6):1277-85. doi: 10.1124/dmd.108.025643. Epub 2009 Mar 19.
5. Clinical impact of ABCC1 and ABCC2 genotypes and haplotypes in mediating imatinib resistance among chronic myeloid leukaemia patients. Au A, etal., J Clin Pharm Ther. 2014 Dec;39(6):685-90. doi: 10.1111/jcpt.12197. Epub 2014 Jul 24.
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