Ckm (creatine kinase, M-type) - Rat Genome Database

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Gene: Ckm (creatine kinase, M-type) Rattus norvegicus
Analyze
Symbol: Ckm
Name: creatine kinase, M-type
RGD ID: 2358
Description: Enables creatine kinase activity. Involved in phosphocreatine biosynthetic process. Predicted to be located in cytoplasm. Predicted to be active in extracellular space. Orthologous to human CKM (creatine kinase, M-type); PARTICIPATES IN creatine metabolic pathway; arginine and proline metabolic pathway; INTERACTS WITH (+)-schisandrin B; (R,R)-tramadol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ckmm; CPK-M; creatine kinase M chain; creatine kinase M-type; Creatine kinase muscle form; creatine kinase, muscle; Creatine kinase, muscle form; creatine phosphokinase M-type; M-CK; muscle creatine kinase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8188,189,382 - 88,199,717 (+)NCBIGRCr8
mRatBN7.2179,061,390 - 79,071,721 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,061,456 - 79,071,720 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx184,450,252 - 84,460,444 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0193,008,139 - 93,018,387 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0186,205,352 - 86,215,542 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0180,321,507 - 80,331,841 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl180,321,585 - 80,331,841 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0181,587,884 - 81,598,112 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4178,762,202 - 78,772,681 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1178,840,312 - 78,850,792 (+)NCBI
Celera173,523,369 - 73,533,981 (+)NCBICelera
RH 3.4 Map1787.5RGD
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(+)-schisandrin B  (EXP)
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
(R,R)-tramadol  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-methyladenine  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
7H-xanthine  (EXP)
9H-xanthine  (EXP)
acrylamide  (EXP)
albuterol  (ISO)
aliskiren  (EXP)
all-trans-retinoic acid  (ISO)
allopurinol  (EXP)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
apigenin  (EXP)
apremilast  (EXP)
arsenous acid  (ISO)
benidipine  (EXP)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
C60 fullerene  (EXP)
cadmium dichloride  (ISO)
cantharidin  (ISO)
captan  (ISO)
carbimazole  (ISO)
carbon nanotube  (ISO)
carfilzomib  (EXP,ISO)
carmustine  (ISO)
carvacrol  (EXP)
carvedilol  (EXP)
celastrol  (EXP)
cetirizine  (ISO)
ciguatoxin CTX1B  (ISO)
Citreoviridin  (EXP,ISO)
clarithromycin  (ISO)
cocaine  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
crocin-1  (EXP)
CU-O LINKAGE  (EXP)
curcumin  (EXP)
cyclophosphamide  (EXP)
daunorubicin  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dichloroacetic acid  (ISO)
dichromium trioxide  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (EXP,ISO)
diuron  (EXP)
doxorubicin  (EXP,ISO)
Echimidine  (EXP)
ethanol  (EXP)
etoposide  (ISO)
Fexofenadine hydrochloride  (ISO)
folpet  (ISO)
furan  (EXP)
gallic acid  (EXP)
genistein  (EXP)
gentamycin  (EXP,ISO)
geraniol  (EXP)
Ginkgolide C  (EXP)
glycerol  (EXP)
graphene oxide  (ISO)
graphite  (ISO)
Heliotrine  (EXP)
hydrazine  (ISO)
hydrogen peroxide  (EXP)
imetit  (EXP)
isoprenaline  (EXP)
isotretinoin  (ISO)
lead diacetate  (EXP,ISO)
lipopolysaccharide  (EXP)
lithium chloride  (ISO)
loperamide  (EXP)
lumiracoxib  (ISO)
mitoxantrone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-acetyl-L-cysteine  (EXP)
nickel atom  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
Pentoxifylline  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phenytoin  (ISO)
PhIP  (EXP)
pioglitazone  (ISO)
pluronic P-123  (EXP)
Poloxamer  (EXP)
proanthocyanidin  (EXP)
progesterone  (EXP)
quercetin  (EXP)
ruthenium atom  (EXP)
silicon dioxide  (ISO)
simvastatin  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium fluoride  (EXP,ISO)
spermine  (ISO)
tetrachloromethane  (EXP)
tetrathiomolybdate(2-)  (ISO)
thiamine(1+) chloride  (EXP,ISO)
titanium dioxide  (ISO)
tramadol  (EXP)
trichloroethene  (EXP)
triclosan  (ISO)
triptonide  (ISO)
tunicamycin  (ISO)
valproic acid  (EXP)
vinclozolin  (EXP)
Vinpocetine  (EXP)
vitamin E  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
extracellular space  (IBA,IEA,ISO,ISS)

Molecular Function
ATP binding  (IEA)
creatine kinase activity  (IBA,IDA,IEA,ISO,TAS)
protein binding  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Isolation and sequence analysis of cDNA clones coding for rat skeletal muscle creatine kinase. Benfield PA, etal., J Biol Chem 1984 Dec 10;259(23):14979-84.
2. Regulation of protein kinase CK2 isoform expression during rat brain development. Diaz-Nido J, etal., Cell Mol Biol Res. 1994;40(5-6):581-5.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
6. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. Myocardial creatine kinase expression after left ventricular assist device support. Park SJ, etal., J Am Coll Cardiol. 2002 Jun 5;39(11):1773-9.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
15. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
16. Myocellular creatine and creatine transporter serine phosphorylation after starvation. Zhao CR, etal., J Surg Res 2002 Jun 1;105(1):10-6.
17. Mouse p53 represses the rat brain creatine kinase gene but activates the rat muscle creatine kinase gene. Zhao J, etal., Mol Cell Biol 1994 Dec;14(12):8483-92.
Additional References at PubMed
PMID:6583703   PMID:12968024   PMID:15489334   PMID:15601660   PMID:16107216   PMID:16371353   PMID:16916915   PMID:17153612   PMID:19182904   PMID:21768101   PMID:24177035   PMID:26116865  
PMID:26316108   PMID:29476059  


Genomics

Comparative Map Data
Ckm
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8188,189,382 - 88,199,717 (+)NCBIGRCr8
mRatBN7.2179,061,390 - 79,071,721 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,061,456 - 79,071,720 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx184,450,252 - 84,460,444 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0193,008,139 - 93,018,387 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0186,205,352 - 86,215,542 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0180,321,507 - 80,331,841 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl180,321,585 - 80,331,841 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0181,587,884 - 81,598,112 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4178,762,202 - 78,772,681 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1178,840,312 - 78,850,792 (+)NCBI
Celera173,523,369 - 73,533,981 (+)NCBICelera
RH 3.4 Map1787.5RGD
Cytogenetic Map1q21NCBI
CKM
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381945,306,413 - 45,322,875 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1945,306,413 - 45,322,875 (-)EnsemblGRCh38hg38GRCh38
GRCh371945,809,671 - 45,826,133 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361950,501,511 - 50,517,974 (-)NCBINCBI36Build 36hg18NCBI36
Build 341950,501,511 - 50,517,974NCBI
Celera1942,615,239 - 42,631,814 (-)NCBICelera
Cytogenetic Map19q13.32NCBI
HuRef1942,241,505 - 42,258,552 (-)NCBIHuRef
CHM1_11945,812,972 - 45,829,550 (-)NCBICHM1_1
T2T-CHM13v2.01948,133,088 - 48,149,564 (-)NCBIT2T-CHM13v2.0
Ckm
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39719,145,019 - 19,155,508 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl719,138,701 - 19,156,766 (+)EnsemblGRCm39 Ensembl
GRCm38719,411,094 - 19,421,583 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl719,404,776 - 19,422,841 (+)EnsemblGRCm38mm10GRCm38
MGSCv37719,996,443 - 20,006,932 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36718,569,616 - 18,580,105 (+)NCBIMGSCv36mm8
Celera716,817,487 - 16,827,978 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map79.67NCBI
Ckm
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555552,318,072 - 2,336,811 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555552,318,072 - 2,330,733 (-)NCBIChiLan1.0ChiLan1.0
CKM
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22051,466,605 - 51,482,812 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11953,336,131 - 53,354,359 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01942,255,158 - 42,271,467 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11950,854,556 - 50,870,366 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1950,854,556 - 50,870,366 (-)Ensemblpanpan1.1panPan2
CKM
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11110,210,158 - 110,218,937 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1110,210,152 - 110,343,383 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1109,692,858 - 109,701,637 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01110,741,228 - 110,750,012 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1110,739,646 - 110,876,550 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11110,416,843 - 110,425,622 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01110,050,951 - 110,059,969 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01110,920,541 - 110,929,325 (+)NCBIUU_Cfam_GSD_1.0
Ckm
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934917,444,955 - 17,453,704 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367061,790,958 - 1,801,139 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367061,792,298 - 1,801,063 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CKM
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl651,700,507 - 51,714,814 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1651,704,021 - 51,716,935 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Pig Cytomap6q22-6q23NCBI
CKM
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1638,764,229 - 38,778,718 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl638,763,402 - 38,776,301 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607318,361,677 - 18,377,016 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ckm
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249072,215,157 - 2,226,889 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249072,215,260 - 2,226,891 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ckm
71 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:60
Count of miRNA genes:52
Interacting mature miRNAs:58
Transcripts:ENSRNOT00000022895
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15389511782174945Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)17219768090508767Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14936146582174945Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)13483685879836858Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)15034351099980958Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)15389511782174945Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)17843075491209302Rat

Markers in Region
D1Kyo1   No map positions available.
PMC125755P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2179,064,827 - 79,065,021 (+)MAPPERmRatBN7.2
Rnor_6.0180,324,950 - 80,325,143NCBIRnor6.0
Rnor_5.0181,591,222 - 81,591,415UniSTSRnor5.0
RGSC_v3.4178,765,540 - 78,765,733UniSTSRGSC3.4
Celera173,526,734 - 73,526,927UniSTS
Cytogenetic Map1q21UniSTS
D1Bda2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2179,071,431 - 79,071,698 (+)MAPPERmRatBN7.2
Rnor_6.0180,331,552 - 80,331,818NCBIRnor6.0
Rnor_5.0181,597,824 - 81,598,090UniSTSRnor5.0
RGSC_v3.4178,772,393 - 78,772,659UniSTSRGSC3.4
Celera173,533,692 - 73,533,958UniSTS
Cytogenetic Map1q21UniSTS
RH94390  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2179,071,612 - 79,071,710 (+)MAPPERmRatBN7.2
Rnor_6.0180,331,733 - 80,331,830NCBIRnor6.0
Rnor_5.0181,598,005 - 81,598,102UniSTSRnor5.0
RGSC_v3.4178,772,574 - 78,772,671UniSTSRGSC3.4
Celera173,533,873 - 73,533,970UniSTS
RH 3.4 Map1787.5UniSTS
Cytogenetic Map5q36UniSTS
Cytogenetic Map1q21UniSTS
RH138712  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2179,071,461 - 79,071,600 (+)MAPPERmRatBN7.2
Rnor_6.0180,331,582 - 80,331,720NCBIRnor6.0
Rnor_5.0181,597,854 - 81,597,992UniSTSRnor5.0
RGSC_v3.4178,772,423 - 78,772,561UniSTSRGSC3.4
Celera173,533,722 - 73,533,860UniSTS
RH 3.4 Map1819.7UniSTS
Cytogenetic Map1q21UniSTS
Ckmm  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2179,064,837 - 79,066,141 (+)MAPPERmRatBN7.2
Rnor_6.0180,324,960 - 80,326,263NCBIRnor6.0
Rnor_5.0181,591,232 - 81,592,535UniSTSRnor5.0
RGSC_v3.4178,765,550 - 78,766,853UniSTSRGSC3.4
Celera173,526,744 - 73,528,047UniSTS
Cytogenetic Map1q21UniSTS
Ckm  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2179,069,990 - 79,071,472 (+)MAPPERmRatBN7.2
Rnor_6.0180,330,112 - 80,331,592NCBIRnor6.0
Rnor_5.0181,596,384 - 81,597,864UniSTSRnor5.0
Cytogenetic Map1q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 52 62 61 30 25 30 6 185 97 32 41 56 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC062058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR458343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DN931989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM053193 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM056549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214750 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214931 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215410 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217421 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223659 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M10140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M14864 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M27092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000022895   ⟹   ENSRNOP00000022895
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl179,061,456 - 79,071,720 (+)Ensembl
Rnor_6.0 Ensembl180,321,585 - 80,331,841 (+)Ensembl
RefSeq Acc Id: NM_012530   ⟹   NP_036662
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8188,189,461 - 88,199,717 (+)NCBI
mRatBN7.2179,061,463 - 79,071,721 (+)NCBI
Rnor_6.0180,321,585 - 80,331,841 (+)NCBI
Rnor_5.0181,587,884 - 81,598,112 (+)NCBI
RGSC_v3.4178,762,202 - 78,772,681 (+)RGD
Celera173,523,369 - 73,533,981 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017588776   ⟹   XP_017444265
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8188,189,382 - 88,199,717 (+)NCBI
mRatBN7.2179,061,390 - 79,071,721 (+)NCBI
Rnor_6.0180,321,507 - 80,331,841 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_036662 (Get FASTA)   NCBI Sequence Viewer  
  XP_017444265 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40935 (Get FASTA)   NCBI Sequence Viewer  
  AAA40936 (Get FASTA)   NCBI Sequence Viewer  
  AAH62058 (Get FASTA)   NCBI Sequence Viewer  
  EDM08202 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000022895.1
GenBank Protein P00564 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036662   ⟸   NM_012530
- UniProtKB: A0A0G2JSP8 (UniProtKB/TrEMBL),   A6J8N1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017444265   ⟸   XM_017588776
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000022895   ⟸   ENSRNOT00000022895
Protein Domains
Phosphagen kinase C-terminal   Phosphagen kinase N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P00564-F1-model_v2 AlphaFold P00564 1-381 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689772
Promoter ID:EPDNEW_R296
Type:multiple initiation site
Name:Ckm_1
Description:creatine kinase, M-type
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0180,321,609 - 80,321,669EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2358 AgrOrtholog
BioCyc Gene G2FUF-60504 BioCyc
BioCyc Pathway PWY-6158 [creatine phosphate biosynthesis] BioCyc
BioCyc Pathway Image PWY-6158 BioCyc
Ensembl Genes ENSRNOG00000016837 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022895.5 UniProtKB/TrEMBL
Gene3D-CATH 1.10.135.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutamine synthetase/guanido kinase, catalytic domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5598226 IMAGE-MGC_LOAD
InterPro ATP-guanido_PTrfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATP-guanido_PTrfase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATP-guanido_PTrfase_cat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATP-guanido_PTrfase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATP-guanido_PTrfase_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gln_synth/guanido_kin_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24265 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72543 IMAGE-MGC_LOAD
NCBI Gene 24265 ENTREZGENE
PANTHER CREATINE KINASE M-TYPE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11547 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ATP-gua_Ptrans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATP-gua_PtransN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ckm PhenoGen
PROSITE PHOSPHAGEN_KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PHOSPHAGEN_KINASE_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PHOSPHAGEN_KINASE_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016837 RatGTEx
Superfamily-SCOP SSF48034 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55931 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC228777
UniProt A0A0G2JSP8 ENTREZGENE, UniProtKB/TrEMBL
  A6J8N1 ENTREZGENE, UniProtKB/TrEMBL
  KCRM_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q6P6R9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Ckm  creatine kinase, M-type  Ckm  creatine kinase, muscle  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Ckm  creatine kinase, muscle    Creatine kinase, muscle form  Name updated 625702 APPROVED
2002-06-10 Ckm  Creatine kinase, muscle form      Symbol and Name status set to approved 70586 APPROVED