Mirlet7d (microRNA let-7d) - Rat Genome Database

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Gene: Mirlet7d (microRNA let-7d) Rattus norvegicus
Analyze
Symbol: Mirlet7d (Ensembl: Mir3596b)
Name: microRNA let-7d (Ensembl:microRNA 3596b)
RGD ID: 2325622
Description: Predicted to act upstream of or within several processes, including BMP signaling pathway; embryo implantation; and long-term synaptic potentiation. Predicted to be part of RISC complex. Orthologous to human MIRLET7D (microRNA let-7d); INTERACTS WITH bleomycin A2; cisplatin; diclofenac.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: rno-let-7d
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81716,322,260 - 16,322,357 (+)NCBIGRCr8
mRatBN7.21716,115,893 - 16,115,990 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1716,115,893 - 16,115,990 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1715,995,816 - 15,995,913 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01717,600,801 - 17,600,898 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01715,922,615 - 15,922,712 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01716,419,980 - 16,420,077 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1716,419,980 - 16,420,077 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01718,476,093 - 18,476,190 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1715,841,950 - 15,842,047 (+)NCBICelera
Cytogenetic Map17p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
RISC complex  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:14691248   PMID:15345052   PMID:16381832   PMID:16766679   PMID:17604727   PMID:18556655   PMID:18723672   PMID:19520079   PMID:19703567   PMID:20403161   PMID:20548288   PMID:20557304  
PMID:21266788   PMID:21307844   PMID:22393433   PMID:23185045   PMID:23646144   PMID:24205035   PMID:24953987   PMID:25751060   PMID:25799420   PMID:25858512   PMID:26802971   PMID:27526122  
PMID:27693697   PMID:32646740   PMID:32667865  


Genomics

Comparative Map Data
Mirlet7d
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81716,322,260 - 16,322,357 (+)NCBIGRCr8
mRatBN7.21716,115,893 - 16,115,990 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1716,115,893 - 16,115,990 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1715,995,816 - 15,995,913 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01717,600,801 - 17,600,898 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01715,922,615 - 15,922,712 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01716,419,980 - 16,420,077 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1716,419,980 - 16,420,077 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01718,476,093 - 18,476,190 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1715,841,950 - 15,842,047 (+)NCBICelera
Cytogenetic Map17p14NCBI
MIRLET7D
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38994,178,834 - 94,178,920 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl994,178,834 - 94,178,920 (+)EnsemblGRCh38hg38GRCh38
GRCh37996,941,116 - 96,941,202 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36995,980,936 - 95,981,022 (+)NCBINCBI36Build 36hg18NCBI36
Celera967,382,672 - 67,382,758 (+)NCBICelera
Cytogenetic Map9q22.32NCBI
HuRef966,618,795 - 66,618,881 (+)NCBIHuRef
CHM1_1997,087,961 - 97,088,047 (+)NCBICHM1_1
T2T-CHM13v2.09106,346,882 - 106,346,968 (+)NCBIT2T-CHM13v2.0
Mirlet7d
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391348,689,488 - 48,689,590 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1348,689,488 - 48,689,590 (-)EnsemblGRCm39 Ensembl
GRCm381348,536,012 - 48,536,114 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1348,536,012 - 48,536,114 (-)EnsemblGRCm38mm10GRCm38
MGSCv371348,631,381 - 48,631,483 (-)NCBIGRCm37MGSCv37mm9NCBIm37
Celera1349,625,959 - 49,626,061 (-)NCBICelera
Cytogenetic Map13A5NCBI
MIRLET7D
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1197,902,012 - 97,902,136 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl197,902,012 - 97,902,136 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha198,298,270 - 98,298,394 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0198,519,286 - 98,519,410 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1198,134,696 - 98,134,820 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0197,870,401 - 97,870,525 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0198,624,856 - 98,624,980 (-)NCBIUU_Cfam_GSD_1.0
MIRLET7D
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl343,468,501 - 43,468,596 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1343,468,501 - 43,468,596 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2344,867,267 - 44,867,362 (+)NCBISscrofa10.2Sscrofa10.2susScr3

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Hmox1rno-let-7d-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18258830
Bdnfrno-let-7d-5pMirtarbaseexternal_infoWestern blot;qRT-PCRNon-Functional MTI19703567
Thrno-let-7d-5pMirtarbaseexternal_infoReporter assay;qRT-PCRFunctional MTI20557304
Vimrno-let-7d-3pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18258830

Predicted Targets
Summary Value
Count of predictions:14533
Count of gene targets:7541
Count of transcripts:8066
Interacting mature miRNAs:rno-let-7d-3p, rno-let-7d-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17999128640540197Rat
631499Stl1Serum triglyceride level QTL 13.6blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)17327139827389946Rat
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17435448727028127Rat
1354640Scl32Serum cholesterol level QTL 325.4blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)171578159260781592Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17211514934551001Rat
1582224Epfw4Epididymal fat weight QTL 43.50.0058epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)17920136523653323Rat
1582225Bw67Body weight QTL 676.20.0001body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
1582226Bw64Body weight QTL 644.20.0017body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131701463Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17452803849528038Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1582208Kidm32Kidney mass QTL 323.90.0018kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17920136523653323Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
1549900Iddm20Insulin dependent diabetes mellitus QTL 203.7pancreas integrity trait (VT:0010560)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)171398677321975515Rat
1331720Rf43Renal function QTL 432.881kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)171533061323017269Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17429913035837242Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171533061355836425Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)17429913021293263Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17131990913Rat
1581553Pur14Proteinuria QTL 145.30.0001urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)17797996816317111Rat
2303561Bw91Body weight QTL 912body mass (VT:0001259)body weight (CMO:0000012)17886846253868462Rat
1582258Bw76Body weight QTL 764.60.0005body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat
1582199Insul5Insulin level QTL 53.40.0119blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)17920136523653323Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
2293648Bmd31Bone mineral density QTL 314.50.0001femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)17435448727028127Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)17211514921881669Rat
1354659Scl68Serum cholesterol level QTL 683.9blood VLDL cholesterol amount (VT:0005144)blood very low density lipoprotein cholesterol level (CMO:0000648)171578159260781592Rat
1582241Bw70Body weight QTL 704.60.0003body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
1582245Bw73Body weight QTL 734.60.0004body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122871563Rat

Markers in Region
RH132637  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21716,116,269 - 16,116,452 (+)MAPPERmRatBN7.2
Rnor_6.01716,420,357 - 16,420,539NCBIRnor6.0
Rnor_5.01718,476,470 - 18,476,652UniSTSRnor5.0
RGSC_v3.41722,122,271 - 22,122,453UniSTSRGSC3.4
Celera1715,842,327 - 15,842,509UniSTS
RH 3.4 Map17179.91UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
5 9 49 101 68 68 38 23 38 6 175 90 81 34 51 30

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_031774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000053717
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1716,115,893 - 16,115,990 (+)Ensembl
Rnor_6.0 Ensembl1716,419,980 - 16,420,077 (+)Ensembl
RefSeq Acc Id: NR_031774
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81716,322,260 - 16,322,357 (+)NCBI
mRatBN7.21716,115,893 - 16,115,990 (+)NCBI
Rnor_6.01716,419,980 - 16,420,077 (+)NCBI
Rnor_5.01718,476,093 - 18,476,190 (+)NCBI
Celera1715,841,950 - 15,842,047 (+)NCBI
Sequence:
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325622 AgrOrtholog
BioCyc Gene G2FUF-9961 BioCyc
Ensembl Genes ENSRNOG00000035594 Ensembl
miRBase MI0000601 ENTREZGENE
NCBI Gene 100313972 ENTREZGENE
PhenoGen Mirlet7d PhenoGen
RatGTEx ENSRNOG00000035594 RatGTEx
RNAcentral URS00000A07C1 RNACentral
  URS000028D142 RNACentral
  URS000075B574 RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-06-02 Mirlet7d  microRNA let-7d      Symbol and Name status set to provisional 70820 PROVISIONAL