Mir17 (microRNA 17) - Rat Genome Database

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Gene: Mir17 (microRNA 17) Rattus norvegicus
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Symbol: Mir17
Name: microRNA 17
RGD ID: 2325600
Description: Predicted to enable mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Involved in negative regulation of ERK1 and ERK2 cascade; positive regulation of apoptotic process; and positive regulation of endothelial cell proliferation. Predicted to be located in extracellular exosome. Predicted to be part of RISC complex. Used to study acute myocardial infarction. Orthologous to human MIR17 (microRNA 17); INTERACTS WITH 2-acetamidofluorene; atrazine; bleomycin A2.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: microRNA mir-17-1; Mir17-1; rno-mir-17-1
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81598,587,848 - 98,587,931 (+)NCBIGRCr8
mRatBN7.21592,180,629 - 92,180,712 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1592,180,629 - 92,180,712 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1596,087,418 - 96,087,501 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01597,220,284 - 97,220,367 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01594,127,690 - 94,127,773 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.015100,179,879 - 100,179,962 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl15100,179,879 - 100,179,962 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.015103,640,902 - 103,640,985 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1591,045,309 - 91,045,392 (+)NCBICelera
Cytogenetic Map15q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
B cell apoptotic process  (ISO)
cellular response to decreased oxygen levels  (ISO)
cellular response to forskolin  (ISO)
cellular response to hypoxia  (ISO)
cellular response to inorganic substance  (ISO)
in utero embryonic development  (ISO)
long-term synaptic potentiation  (ISO)
lung development  (ISO)
miRNA-mediated gene silencing by inhibition of translation  (ISO)
miRNA-mediated post-transcriptional gene silencing  (ISO)
multicellular organismal-level iron ion homeostasis  (ISO)
negative regulation of amyloid precursor protein biosynthetic process  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of chemokine production  (ISO)
negative regulation of ERK1 and ERK2 cascade  (IMP)
negative regulation of gene expression  (ISO)
negative regulation of low-density lipoprotein particle clearance  (ISO)
negative regulation of osteoblast differentiation  (ISO)
negative regulation of receptor-mediated endocytosis involved in cholesterol transport  (ISO)
negative regulation of sprouting angiogenesis  (ISO)
negative regulation of toll-like receptor signaling pathway  (ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (ISO)
negative regulation of vascular associated smooth muscle cell apoptotic process  (ISO)
negative regulation of vascular endothelial growth factor production  (ISO)
positive regulation of apoptotic process  (IMP)
positive regulation of endothelial cell proliferation  (IMP)
positive regulation of fat cell differentiation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
pre-B cell differentiation  (ISO)
response to bacterium  (ISO)
response to wounding  (ISO)
sensory perception of sound  (ISO)
spinal cord motor neuron differentiation  (ISO)
ventricular septum morphogenesis  (ISO)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Identification of Spinal Cord MicroRNA and Gene Signatures in a Model of Chronic Stress-Induced Visceral Hyperalgesia in Rat. Bradesi S, etal., PLoS One. 2015 Jul 29;10(7):e0130938. doi: 10.1371/journal.pone.0130938. eCollection 2015.
2. Diosmin attenuates radiation-induced hepatic fibrosis by boosting PPAR-γ expression and hampering miR-17-5p-activated canonical Wnt-β-catenin signaling. Hasan HF, etal., Biochem Cell Biol. 2017 Jun;95(3):400-414. doi: 10.1139/bcb-2016-0142. Epub 2016 Nov 21.
3. LncRNA H19 interacted with miR-130a-3p and miR-17-5p to modify radio-resistance and chemo-sensitivity of cardiac carcinoma cells. Jia J, etal., Cancer Med. 2019 Apr;8(4):1604-1618. doi: 10.1002/cam4.1860. Epub 2019 Mar 6.
4. MicroRNA-17 as a potential diagnostic biomarker in pulmonary arterial hypertension. Li H, etal., J Int Med Res. 2020 Jun;48(6):300060520920430. doi: 10.1177/0300060520920430.
5. HIF1A and VEGF regulate each other by competing endogenous RNA mechanism and involve in the pathogenesis of peritoneal fibrosis. Li J, etal., Pathol Res Pract. 2019 Apr;215(4):644-652. doi: 10.1016/j.prp.2018.12.022. Epub 2018 Dec 26.
6. Human umbilical cord mesenchymal stem cells-derived exosomal microRNA-17-3p ameliorates inflammatory reaction and antioxidant injury of mice with diabetic retinopathy via targeting STAT1. Li W, etal., Int Immunopharmacol. 2021 Jan;90:107010. doi: 10.1016/j.intimp.2020.107010. Epub 2020 Dec 14.
7. MiR-17-5p protects neonatal mice from hypoxic-ischemic brain damage by targeting Casp2. Niu X, etal., Neurosci Lett. 2022 Feb 16;772:136475. doi: 10.1016/j.neulet.2022.136475. Epub 2022 Jan 24.
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Inhibition of microRNA-17-5p reduces the inflammation and lipid accumulation, and up-regulates ATP-binding cassette transporterA1 in atherosclerosis. Tan L, etal., J Pharmacol Sci. 2019 Apr;139(4):280-288. doi: 10.1016/j.jphs.2018.11.012. Epub 2018 Dec 6.
10. Improved risk stratification in myeloma using a microRNA-based classifier. Wu P, etal., Br J Haematol. 2013 Aug;162(3):348-59. doi: 10.1111/bjh.12394. Epub 2013 May 30.
11. Downregulation of microRNA-17-5p improves cardiac function after myocardial infarction via attenuation of apoptosis in endothelial cells. Yang S, etal., Mol Genet Genomics. 2018 Aug;293(4):883-894. doi: 10.1007/s00438-018-1426-5. Epub 2018 Mar 13.
12. Inhibition of miR-17-5p promotes mesenchymal stem cells to repair spinal cord injury. Yue XH, etal., Eur Rev Med Pharmacol Sci. 2019 May;23(9):3899-3907. doi: 10.26355/eurrev_201905_17819.
Additional References at PubMed
PMID:15345052   PMID:16381832   PMID:17604727   PMID:18320040   PMID:18329372   PMID:19147652   PMID:20403161   PMID:21338882   PMID:21364282   PMID:21993888   PMID:23185045   PMID:23646144  
PMID:24205035   PMID:25858512   PMID:25915722   PMID:26265044   PMID:26637809   PMID:29351283   PMID:29574156   PMID:29644896   PMID:30030064   PMID:30092337   PMID:30170066   PMID:30648109  
PMID:31093905   PMID:31359738   PMID:32095982   PMID:33315517   PMID:34120306   PMID:34414456   PMID:34495404   PMID:34879291   PMID:34958294   PMID:37976598  


Genomics

Comparative Map Data
Mir17
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81598,587,848 - 98,587,931 (+)NCBIGRCr8
mRatBN7.21592,180,629 - 92,180,712 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1592,180,629 - 92,180,712 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1596,087,418 - 96,087,501 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01597,220,284 - 97,220,367 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01594,127,690 - 94,127,773 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.015100,179,879 - 100,179,962 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl15100,179,879 - 100,179,962 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.015103,640,902 - 103,640,985 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1591,045,309 - 91,045,392 (+)NCBICelera
Cytogenetic Map15q23NCBI
MIR17
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381391,350,605 - 91,350,688 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1391,350,605 - 91,350,688 (+)EnsemblGRCh38hg38GRCh38
GRCh371392,002,859 - 92,002,942 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361390,800,859 - 90,800,942 (+)NCBINCBI36Build 36hg18NCBI36
Celera1372,849,830 - 72,849,913 (+)NCBICelera
Cytogenetic Map13q31.3NCBI
HuRef1372,598,694 - 72,598,777 (+)NCBIHuRef
CHM1_11391,971,499 - 91,971,582 (+)NCBICHM1_1
T2T-CHM13v2.01390,553,181 - 90,553,264 (+)NCBIT2T-CHM13v2.0
Mir17
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3914115,281,103 - 115,281,186 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl14115,281,103 - 115,281,186 (+)EnsemblGRCm39 Ensembl
GRCm3814115,043,671 - 115,043,754 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl14115,043,671 - 115,043,754 (+)EnsemblGRCm38mm10GRCm38
MGSCv3714115,442,893 - 115,442,976 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera14113,634,239 - 113,634,322 (+)NCBICelera
Cytogenetic Map14E4NCBI
cM Map1459.4NCBI
MIR17
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12242,478,013 - 42,478,071 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2242,478,000 - 42,478,083 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2242,333,701 - 42,333,759 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02242,879,262 - 42,879,320 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2242,879,249 - 42,879,332 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12242,561,735 - 42,561,793 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02242,616,114 - 42,616,172 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02242,617,177 - 42,617,235 (+)NCBIUU_Cfam_GSD_1.0
MIR17
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1160,734,656 - 60,734,732 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11160,734,656 - 60,734,732 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21166,610,060 - 66,610,136 (+)NCBISscrofa10.2Sscrofa10.2susScr3

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:6500
Count of gene targets:4537
Count of transcripts:4929
Interacting mature miRNAs:rno-miR-17-1-3p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631655Bp126Blood pressure QTL 1264arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1558156477101769107Rat
2317055Aia10Adjuvant induced arthritis QTL 103.41joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1575788062101769107Rat
731177Uae26Urinary albumin excretion QTL 262.40.025urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1567588667101769107Rat
631516Gluco31Glucose level QTL 317blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)155559608995018120Rat
1300118Bp190Blood pressure QTL 1902.94arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)158226252098288169Rat
1300120Kidm7Kidney mass QTL 73.55kidney mass (VT:0002707)left kidney wet weight to body weight ratio (CMO:0001954)158226252098288169Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)154063126898288169Rat
1331724Bp223Blood pressure QTL 2233.53715arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)157369051895018228Rat
1549844Bss7Bone structure and strength QTL 76.4femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1575788062101769107Rat
1581519Cm59Cardiac mass QTL 592.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)158885347095840528Rat
1576315Schws6Schwannoma susceptibility QTL 60.0069nervous system integrity trait (VT:0010566)post-insult time of death (CMO:0002005)155380615298806152Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
70182BpQTLcluster12Blood pressure QTL cluster 123.53arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)157369065795018120Rat
1641889Colcr6Colorectal carcinoma resistance QTL 62.90.0126intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)157369051899794247Rat
2300326Plaw1Placental weight QTL 1150.005placenta mass (VT:0004257)placenta wet weight (CMO:0002088)1568327165100062518Rat
70155Gcs1Gastric cancer susceptibility QTL13.8stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)1576306099101769107Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system appendage
High
Medium
Low 8 2 9 2 1 1 2 9 5 1
Below cutoff 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_031818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000053780
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1592,180,629 - 92,180,712 (+)Ensembl
Rnor_6.0 Ensembl15100,179,879 - 100,179,962 (+)Ensembl
RefSeq Acc Id: NR_031818
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81598,587,848 - 98,587,931 (+)NCBI
mRatBN7.21592,180,629 - 92,180,712 (+)NCBI
Rnor_6.015100,179,879 - 100,179,962 (+)NCBI
Rnor_5.015103,640,902 - 103,640,985 (+)NCBI
Celera1591,045,309 - 91,045,392 (+)NCBI
Sequence:
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325600 AgrOrtholog
BioCyc Gene G2FUF-12498 BioCyc
Ensembl Genes ENSRNOG00000035657 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000053780 ENTREZGENE
miRBase MI0000845 ENTREZGENE
NCBI Gene 100313998 ENTREZGENE
PhenoGen Mir17 PhenoGen
RatGTEx ENSRNOG00000035657 RatGTEx
RNAcentral URS00002075FA RNACentral
  URS000075CE75 RNACentral
  URS000075EC1D RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-09-17 Mir17  microRNA 17  Mir17-1  microRNA mir-17-1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-06-02 Mir17-1  microRNA mir-17-1      Symbol and Name status set to provisional 70820 PROVISIONAL