Mir125b2 (microRNA 125b-2) - Rat Genome Database

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Gene: Mir125b2 (microRNA 125b-2) Rattus norvegicus
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Symbol: Mir125b2
Name: microRNA 125b-2
RGD ID: 2325575
Description: Predicted to enable mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Predicted to be involved in several processes, including negative regulation of gene expression; negative regulation of signal transduction; and positive regulation of cell differentiation. Predicted to act upstream of or within several processes, including cellular response to cytokine stimulus; cellular response to forskolin; and common myeloid progenitor cell proliferation. Predicted to be located in extracellular exosome. Orthologous to human MIR125B2 (microRNA 125b-2); INTERACTS WITH nitrofen; paracetamol; stanozolol.
Type: ncrna
RefSeq Status: PROVISIONAL
Previously known as: Mir125b-2; rno-mir-125b-2
RGD Orthologs
Human
Mouse
Dog
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81129,732,572 - 29,732,659 (+)NCBIGRCr8
mRatBN7.21116,245,620 - 16,245,707 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1124,899,593 - 24,899,680 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01117,614,454 - 17,614,541 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01116,775,310 - 16,775,397 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01116,097,346 - 16,097,433 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01119,752,280 - 19,752,367 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1116,251,853 - 16,251,940 (+)NCBICelera
Cytogenetic Map11q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to forskolin  (ISO)
cellular response to inorganic substance  (ISO)
cellular response to interleukin-6  (ISO)
cellular response to leukemia inhibitory factor  (ISO)
cellular response to tumor necrosis factor  (ISO)
cellular response to vitamin D  (ISO)
common myeloid progenitor cell proliferation  (ISO)
hematopoietic stem cell differentiation  (ISO)
juxtaglomerular apparatus development  (ISO)
long-term synaptic potentiation  (ISO)
miRNA-mediated gene silencing by inhibition of translation  (ISO)
miRNA-mediated gene silencing by mRNA destabilization  (ISO)
miRNA-mediated post-transcriptional gene silencing  (ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of BMP signaling pathway  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of interleukin-6-mediated signaling pathway  (ISO)
negative regulation of keratinocyte proliferation  (ISO)
negative regulation of monocyte differentiation  (ISO)
negative regulation of osteoblast differentiation  (ISO)
negative regulation of receptor signaling pathway via STAT  (ISO)
negative regulation of tumor necrosis factor production  (ISO)
negative regulation of tumor necrosis factor-mediated signaling pathway  (ISO)
ossification  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of glial cell proliferation  (ISO)
positive regulation of keratinocyte differentiation  (ISO)
positive regulation of vascular associated smooth muscle cell differentiation  (ISO)
sensory perception of sound  (ISO)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:14691248   PMID:15345052   PMID:16381832   PMID:16766679   PMID:17604727   PMID:17805466   PMID:19188425   PMID:20403161   PMID:20439489   PMID:20660734   PMID:21993888   PMID:23016664  
PMID:23536218   PMID:23646144   PMID:25751060   PMID:25858512   PMID:26729468   PMID:28281528   PMID:28522697   PMID:29510389   PMID:31000329   PMID:31548167   PMID:33909769   PMID:34563514  
PMID:34889563   PMID:37958999  


Genomics

Comparative Map Data
Mir125b2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81129,732,572 - 29,732,659 (+)NCBIGRCr8
mRatBN7.21116,245,620 - 16,245,707 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1124,899,593 - 24,899,680 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01117,614,454 - 17,614,541 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01116,775,310 - 16,775,397 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01116,097,346 - 16,097,433 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01119,752,280 - 19,752,367 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1116,251,853 - 16,251,940 (+)NCBICelera
Cytogenetic Map11q11NCBI
MIR125B2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382116,590,237 - 16,590,325 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2116,590,237 - 16,590,325 (+)EnsemblGRCh38hg38GRCh38
GRCh372117,962,557 - 17,962,645 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362116,884,427 - 16,884,515 (+)NCBINCBI36Build 36hg18NCBI36
Celera213,132,744 - 3,132,832 (+)NCBICelera
Cytogenetic Map21q21.1NCBI
HuRef213,343,306 - 3,343,394 (+)NCBIHuRef
CHM1_12117,523,172 - 17,523,260 (+)NCBICHM1_1
T2T-CHM13v2.02114,945,711 - 14,945,799 (+)NCBIT2T-CHM13v2.0
Mir125b-2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391677,443,161 - 77,443,231 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1677,443,161 - 77,443,231 (+)EnsemblGRCm39 Ensembl
GRCm381677,646,273 - 77,646,343 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1677,646,273 - 77,646,343 (+)EnsemblGRCm38mm10GRCm38
MGSCv371677,646,518 - 77,646,588 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera1677,873,203 - 77,873,273 (+)NCBICelera
Cytogenetic Map16C3.1NCBI
cM Map1644.71NCBI
MIR125B-2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13113,304,980 - 13,305,040 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3113,304,964 - 13,305,052 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3113,318,783 - 13,318,843 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03113,334,446 - 13,334,506 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3113,334,430 - 13,334,518 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13113,303,634 - 13,303,694 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03113,342,383 - 13,342,443 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03113,742,924 - 13,742,984 (+)NCBIUU_Cfam_GSD_1.0

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:7740
Count of gene targets:5021
Count of transcripts:5434
Interacting mature miRNAs:rno-miR-125b-2-3p, rno-miR-125b-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634341Bw121Body weight QTL 1213.56abdominal fat pad mass (VT:1000711)abdominal fat pad weight (CMO:0000088)11121836709Rat
1598842Glom10Glomerulus QTL 103.4kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)11135331169Rat
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
1641927Alcrsp10Alcohol response QTL 10alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)11843667453436674Rat
2290451Scl58Serum cholesterol level QTL 583.48blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)111283104625121472Rat


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NR_031870 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: NR_031870
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81129,732,572 - 29,732,659 (+)NCBI
mRatBN7.21116,245,620 - 16,245,707 (+)NCBI
Rnor_6.01116,097,346 - 16,097,433 (+)NCBI
Rnor_5.01119,752,280 - 19,752,367 (+)NCBI
Celera1116,251,853 - 16,251,940 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325575 AgrOrtholog
BioCyc Gene G2FUF-22151 BioCyc
miRBase MI0000897 ENTREZGENE
NCBI Gene 100314025 ENTREZGENE
PhenoGen Mir125b2 PhenoGen
RNAcentral URS0000209905 RNACentral
  URS00004FCB5F RNACentral
  URS000075A606 RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-05-23 Mir125b2  microRNA 125b-2  Mir125b-2  microRNA 125b-2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-04-09 Mir125b-2  microRNA 125b-2  Mir125b-2  microRNA mir-125b-2  Name updated 61478 APPROVED
2010-06-02 Mir125b-2  microRNA mir-125b-2      Symbol and Name status set to provisional 70820 PROVISIONAL