Mir19a (microRNA 19a) - Rat Genome Database

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Gene: Mir19a (microRNA 19a) Rattus norvegicus
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Symbol: Mir19a
Name: microRNA 19a
RGD ID: 2325462
Description: Predicted to enable mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Predicted to be involved in several processes, including positive regulation of nitrogen compound metabolic process; regulation of cellular response to transforming growth factor beta stimulus; and regulation of signal transduction. Predicted to act upstream of or within several processes, including long-term synaptic potentiation; pre-B cell differentiation; and ventricular septum morphogenesis. Orthologous to human MIR19A (microRNA 19a); INTERACTS WITH 2-methoxyethanol; aflatoxin B1; atrazine.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: microRNA mir-19a; rno-mir-19a
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81598,588,131 - 98,588,212 (+)NCBIGRCr8
mRatBN7.21592,180,912 - 92,180,993 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1592,180,912 - 92,180,993 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1596,087,701 - 96,087,782 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01597,220,567 - 97,220,648 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01594,127,973 - 94,128,054 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.015100,180,162 - 100,180,243 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl15100,180,162 - 100,180,243 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.015103,641,185 - 103,641,266 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1591,045,592 - 91,045,673 (+)NCBICelera
Cytogenetic Map15q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
B cell activation  (ISO)
B cell apoptotic process  (ISO)
cellular response to bacterial lipopeptide  (ISO)
in utero embryonic development  (ISO)
long-term synaptic potentiation  (ISO)
lung development  (ISO)
miRNA-mediated gene silencing by mRNA destabilization  (ISO)
miRNA-mediated post-transcriptional gene silencing  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cardiac epithelial to mesenchymal transition  (ISO)
negative regulation of cellular response to transforming growth factor beta stimulus  (ISO)
negative regulation of extracellular matrix assembly  (ISO)
negative regulation of fibroblast migration  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of inflammatory response  (ISO)
negative regulation of inflammatory response to antigenic stimulus  (ISO)
negative regulation of interleukin-6 production  (ISO)
negative regulation of matrix metallopeptidase secretion  (ISO)
negative regulation of sprouting angiogenesis  (ISO)
negative regulation of toll-like receptor signaling pathway  (ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (ISO)
positive regulation of B cell receptor signaling pathway  (ISO)
positive regulation of cell growth involved in cardiac muscle cell development  (ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO)
pre-B cell differentiation  (ISO)
regulation of cardiac conduction  (ISO)
spinal cord motor neuron differentiation  (ISO)
ventricular septum morphogenesis  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. LncRNA H19 Aggravates Cerebral Ischemia/Reperfusion Injury by Functioning as a ceRNA for miR-19a-3p to Target PTEN. Gao N, etal., Neuroscience. 2020 Jun 15;437:117-129. doi: 10.1016/j.neuroscience.2020.04.020. Epub 2020 Apr 24.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. MicroRNA Microarray-Based Identification of Involvement of miR-155 and miR-19a in Development of Oral Lichen Planus (OLP) by Modulating Th1/Th2 Balance via Targeting eNOS and Toll-Like Receptor 2 (TLR2). Wang L, etal., Med Sci Monit. 2018 May 29;24:3591-3603. doi: 10.12659/MSM.907497.
Additional References at PubMed
PMID:16381832   PMID:17604727   PMID:18329372   PMID:20403161   PMID:21338882   PMID:24117217   PMID:25858512   PMID:26381867   PMID:26617805   PMID:27220268   PMID:29054970   PMID:31168302  
PMID:31573047   PMID:31633225   PMID:31924121   PMID:32096186   PMID:32271450   PMID:34051800   PMID:36334791   PMID:36539014   PMID:37218372   PMID:37393018  


Genomics

Comparative Map Data
Mir19a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81598,588,131 - 98,588,212 (+)NCBIGRCr8
mRatBN7.21592,180,912 - 92,180,993 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1592,180,912 - 92,180,993 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1596,087,701 - 96,087,782 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01597,220,567 - 97,220,648 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01594,127,973 - 94,128,054 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.015100,180,162 - 100,180,243 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl15100,180,162 - 100,180,243 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.015103,641,185 - 103,641,266 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1591,045,592 - 91,045,673 (+)NCBICelera
Cytogenetic Map15q23NCBI
MIR19A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381391,350,891 - 91,350,972 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1391,350,891 - 91,350,972 (+)EnsemblGRCh38hg38GRCh38
GRCh371392,003,145 - 92,003,226 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361390,801,145 - 90,801,226 (+)NCBINCBI36Build 36hg18NCBI36
Celera1372,850,116 - 72,850,197 (+)NCBICelera
Cytogenetic Map13q31.3NCBI
HuRef1372,598,980 - 72,599,061 (+)NCBIHuRef
CHM1_11391,971,785 - 91,971,866 (+)NCBICHM1_1
T2T-CHM13v2.01390,553,467 - 90,553,548 (+)NCBIT2T-CHM13v2.0
Mir19a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3914115,281,432 - 115,281,513 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl14115,281,432 - 115,281,513 (+)EnsemblGRCm39 Ensembl
GRCm3814115,044,000 - 115,044,081 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl14115,044,000 - 115,044,081 (+)EnsemblGRCm38mm10GRCm38
MGSCv3714115,443,222 - 115,443,303 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera14113,634,568 - 113,634,649 (+)NCBICelera
Cytogenetic Map14E4NCBI
cM Map1459.4NCBI
MIR19A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12242,478,298 - 42,478,355 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2242,478,285 - 42,478,366 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2242,333,986 - 42,334,043 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02242,879,547 - 42,879,604 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2242,879,534 - 42,879,615 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12242,562,020 - 42,562,077 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02242,616,399 - 42,616,456 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02242,617,462 - 42,617,519 (+)NCBIUU_Cfam_GSD_1.0
MIR19A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1160,734,939 - 60,735,020 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11160,734,939 - 60,735,020 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21166,610,343 - 66,610,424 (+)NCBISscrofa10.2Sscrofa10.2susScr3

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:9049
Count of gene targets:5542
Count of transcripts:5932
Interacting mature miRNAs:rno-miR-19a-3p, rno-miR-19a-5p
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631655Bp126Blood pressure QTL 1264arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1558156477101769107Rat
2317055Aia10Adjuvant induced arthritis QTL 103.41joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1575788062101769107Rat
731177Uae26Urinary albumin excretion QTL 262.40.025urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1567588667101769107Rat
631516Gluco31Glucose level QTL 317blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)155559608995018120Rat
1300118Bp190Blood pressure QTL 1902.94arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)158226252098288169Rat
1300120Kidm7Kidney mass QTL 73.55kidney mass (VT:0002707)left kidney wet weight to body weight ratio (CMO:0001954)158226252098288169Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)154063126898288169Rat
1331724Bp223Blood pressure QTL 2233.53715arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)157369051895018228Rat
1549844Bss7Bone structure and strength QTL 76.4femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1575788062101769107Rat
1581519Cm59Cardiac mass QTL 592.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)158885347095840528Rat
1576315Schws6Schwannoma susceptibility QTL 60.0069nervous system integrity trait (VT:0010566)post-insult time of death (CMO:0002005)155380615298806152Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
70182BpQTLcluster12Blood pressure QTL cluster 123.53arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)157369065795018120Rat
1641889Colcr6Colorectal carcinoma resistance QTL 62.90.0126intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)157369051899794247Rat
2300326Plaw1Placental weight QTL 1150.005placenta mass (VT:0004257)placenta wet weight (CMO:0002088)1568327165100062518Rat
70155Gcs1Gastric cancer susceptibility QTL13.8stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)1576306099101769107Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 8 2 14 2 2 2
Low 1 8 16 6 2 6 5 5 14 8 20 6 5
Below cutoff 1 4 4 4 2 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_031822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000053701
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1592,180,912 - 92,180,993 (+)Ensembl
Rnor_6.0 Ensembl15100,180,162 - 100,180,243 (+)Ensembl
RefSeq Acc Id: NR_031822
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81598,588,131 - 98,588,212 (+)NCBI
mRatBN7.21592,180,912 - 92,180,993 (+)NCBI
Rnor_6.015100,180,162 - 100,180,243 (+)NCBI
Rnor_5.015103,641,185 - 103,641,266 (+)NCBI
Celera1591,045,592 - 91,045,673 (+)NCBI
Sequence:
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325462 AgrOrtholog
BioCyc Gene G2FUF-12492 BioCyc
Ensembl Genes ENSRNOG00000035578 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000053701 ENTREZGENE
miRBase MI0000849 ENTREZGENE
NCBI Gene 100314151 ENTREZGENE
PhenoGen Mir19a PhenoGen
RatGTEx ENSRNOG00000035578 RatGTEx
RNAcentral URS000006FDD4 RNACentral
  URS000075E9A5 RNACentral
  URS000075EB4E RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-14 Mir19a  microRNA 19a  Mir19a  microRNA mir-19a  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-06-02 Mir19a  microRNA mir-19a      Symbol and Name status set to provisional 70820 PROVISIONAL