Mirlet7c1 (microRNA let-7c-1) - Rat Genome Database

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Gene: Mirlet7c1 (microRNA let-7c-1) Rattus norvegicus
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Symbol: Mirlet7c1
Name: microRNA let-7c-1
RGD ID: 2325435
Description: Predicted to enable mRNA base-pairing translational repressor activity. Predicted to be involved in miRNA-mediated gene silencing by mRNA destabilization; negative regulation of interleukin-6-mediated signaling pathway; and negative regulation of receptor signaling pathway via STAT. Predicted to act upstream of or within embryo implantation; long-term synaptic potentiation; and negative regulation of gene expression. Predicted to be located in cytoplasm and extracellular exosome. Predicted to be part of RISC complex. Orthologous to human MIRLET7C (microRNA let-7c); INTERACTS WITH 2-acetamidofluorene; cisplatin; mechlorethamine.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: microRNA let7c-1; Mirlet7c-1; rno-let-7c-1
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81129,688,112 - 29,688,205 (+)NCBIGRCr8
mRatBN7.21116,201,163 - 16,201,256 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1116,201,158 - 16,201,265 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1124,854,982 - 24,855,075 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01117,570,030 - 17,570,123 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01116,730,686 - 16,730,779 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01116,052,873 - 16,052,966 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1116,052,868 - 16,052,975 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01119,708,143 - 19,708,236 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1116,207,277 - 16,207,370 (+)NCBICelera
Cytogenetic Map11q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. Differential miRNA Expression in the Liver of Balb/c Mice Protected by Vaccination during Crisis of Plasmodium chabaudi Blood-Stage Malaria. Dkhil MA, etal., Front Microbiol. 2017 Jan 11;7:2155. doi: 10.3389/fmicb.2016.02155. eCollection 2016.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:14691248   PMID:15345052   PMID:15361871   PMID:16381832   PMID:16766679   PMID:17604727   PMID:17805466   PMID:18556655   PMID:20403161   PMID:22844247   PMID:23185045   PMID:24959881  
PMID:25394845   PMID:25858512   PMID:37433785  


Genomics

Comparative Map Data
Mirlet7c1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81129,688,112 - 29,688,205 (+)NCBIGRCr8
mRatBN7.21116,201,163 - 16,201,256 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1116,201,158 - 16,201,265 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1124,854,982 - 24,855,075 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01117,570,030 - 17,570,123 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01116,730,686 - 16,730,779 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01116,052,873 - 16,052,966 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1116,052,868 - 16,052,975 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01119,708,143 - 19,708,236 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1116,207,277 - 16,207,370 (+)NCBICelera
Cytogenetic Map11q11NCBI
MIRLET7C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382116,539,828 - 16,539,911 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2116,539,828 - 16,539,911 (+)EnsemblGRCh38hg38GRCh38
GRCh372117,912,148 - 17,912,231 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362116,834,018 - 16,834,101 (+)NCBINCBI36Build 36hg18NCBI36
Celera213,082,285 - 3,082,368 (+)NCBICelera
Cytogenetic Map21q21.1NCBI
HuRef213,292,822 - 3,292,905 (+)NCBIHuRef
CHM1_12117,472,511 - 17,472,594 (+)NCBICHM1_1
T2T-CHM13v2.02114,895,248 - 14,895,331 (+)NCBIT2T-CHM13v2.0
Mirlet7c-1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391677,396,545 - 77,396,638 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1677,396,545 - 77,396,638 (+)EnsemblGRCm39 Ensembl
GRCm381677,599,657 - 77,599,750 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1677,599,657 - 77,599,750 (+)EnsemblGRCm38mm10GRCm38
MGSCv371677,599,902 - 77,599,995 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera1677,826,647 - 77,826,740 (+)NCBICelera
Cytogenetic Map16C3.1NCBI
cM Map1644.71NCBI
MIRLET7C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13113,259,522 - 13,259,588 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3113,259,502 - 13,259,609 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3113,273,328 - 13,273,394 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03113,288,729 - 13,288,795 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.13113,258,230 - 13,258,296 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03113,296,692 - 13,296,758 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03113,697,466 - 13,697,532 (+)NCBIUU_Cfam_GSD_1.0
MIRLET7C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13181,303,209 - 181,303,302 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113181,303,209 - 181,303,302 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213191,559,336 - 191,559,429 (+)NCBISscrofa10.2Sscrofa10.2susScr3

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Vimrno-let-7c-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18258830

Predicted Targets
Summary Value
Count of predictions:4305
Count of gene targets:2652
Count of transcripts:2894
Interacting mature miRNAs:rno-let-7c-1-3p, rno-let-7c-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634341Bw121Body weight QTL 1213.56abdominal fat pad mass (VT:1000711)abdominal fat pad weight (CMO:0000088)11121836709Rat
1598842Glom10Glomerulus QTL 103.4kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)11135331169Rat
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
1641927Alcrsp10Alcohol response QTL 10alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)11843667453436674Rat
2290451Scl58Serum cholesterol level QTL 583.48blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)111283104625121472Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 6 2
Low 8 19 8 10 8 8 8 22 8 5 6 8
Below cutoff 1 8 8 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_031803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000053623
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1116,201,158 - 16,201,265 (+)Ensembl
Rnor_6.0 Ensembl1116,052,868 - 16,052,975 (+)Ensembl
RefSeq Acc Id: NR_031803
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81129,688,112 - 29,688,205 (+)NCBI
mRatBN7.21116,201,163 - 16,201,256 (+)NCBI
Rnor_6.01116,052,873 - 16,052,966 (+)NCBI
Rnor_5.01119,708,143 - 19,708,236 (+)NCBI
Celera1116,207,277 - 16,207,370 (+)NCBI
Sequence:
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325435 AgrOrtholog
BioCyc Gene G2FUF-22156 BioCyc
Ensembl Genes ENSRNOG00000035500 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000053623 ENTREZGENE
miRBase MI0000830 ENTREZGENE
NCBI Gene 100314184 ENTREZGENE
PhenoGen Mirlet7c1 PhenoGen
RatGTEx ENSRNOG00000035500 RatGTEx
RNAcentral URS000050DE77 RNACentral
  URS000060A34C RNACentral
  URS000075B2B8 RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-05-23 Mirlet7c1  microRNA let-7c-1  Mirlet7c-1  microRNA let7c-1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-08-14 Mirlet7c-1  microRNA let7c-1  Mirlet7c-1  microRNA let-7c-1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-06-02 Mirlet7c-1  microRNA let-7c-1      Symbol and Name status set to provisional 70820 PROVISIONAL