Mirlet7a1 (microRNA let-7a-1) - Rat Genome Database

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Gene: Mirlet7a1 (microRNA let-7a-1) Rattus norvegicus
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Symbol: Mirlet7a1
Name: microRNA let-7a-1
RGD ID: 2325409
Description: Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex. Orthologous to human MIRLET7A1 (microRNA let-7a-1); INTERACTS WITH atrazine; bisphenol A; cisplatin.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: Mirlet7a-1; rno-let-7a-1
RGD Orthologs
Human
Mouse
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81716,320,133 - 16,320,226 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1716,320,135 - 16,320,234 (+)EnsemblGRCr8
mRatBN7.21716,113,766 - 16,113,859 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1716,113,768 - 16,113,867 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1715,993,689 - 15,993,782 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01717,598,674 - 17,598,767 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01715,920,488 - 15,920,581 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01716,417,853 - 16,417,946 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1716,417,855 - 16,417,954 (+)Ensemblrn6Rnor6.0
Rnor_5.01718,473,966 - 18,474,059 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera1715,839,823 - 15,839,916 (+)NCBICelera
Cytogenetic Map17p14NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
malaria  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Differential miRNA Expression in the Liver of Balb/c Mice Protected by Vaccination during Crisis of Plasmodium chabaudi Blood-Stage Malaria. Dkhil MA, etal., Front Microbiol. 2017 Jan 11;7:2155. doi: 10.3389/fmicb.2016.02155. eCollection 2016.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:14691248   PMID:15345052   PMID:16381832   PMID:16766679   PMID:17604727   PMID:18556655   PMID:18604195   PMID:19520079   PMID:19898466   PMID:20403161   PMID:20548288   PMID:21993888  
PMID:23152446   PMID:23185045   PMID:23646144   PMID:24205035   PMID:26698218   PMID:26858302   PMID:28060734   PMID:28187784   PMID:28298326   PMID:30551879   PMID:33204336   PMID:33412132  
PMID:33749722   PMID:37855249  


Genomics

Comparative Map Data
Mirlet7a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81716,320,133 - 16,320,226 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1716,320,135 - 16,320,234 (+)EnsemblGRCr8
mRatBN7.21716,113,766 - 16,113,859 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1716,113,768 - 16,113,867 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1715,993,689 - 15,993,782 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01717,598,674 - 17,598,767 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01715,920,488 - 15,920,581 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01716,417,853 - 16,417,946 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1716,417,855 - 16,417,954 (+)Ensemblrn6Rnor6.0
Rnor_5.01718,473,966 - 18,474,059 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera1715,839,823 - 15,839,916 (+)NCBICelera
Cytogenetic Map17p14NCBI
MIRLET7A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38994,175,957 - 94,176,036 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl994,175,957 - 94,176,036 (+)Ensemblhg38GRCh38
GRCh37996,938,239 - 96,938,318 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36995,978,059 - 95,978,138 (+)NCBIBuild 36Build 36hg18NCBI36
Celera967,379,795 - 67,379,874 (+)NCBICelera
Cytogenetic Map9q22.32NCBI
HuRef966,615,918 - 66,615,997 (+)NCBIHuRef
CHM1_1997,085,084 - 97,085,163 (+)NCBICHM1_1
T2T-CHM13v2.09106,344,005 - 106,344,084 (+)NCBIT2T-CHM13v2.0
Mirlet7a-1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391348,691,655 - 48,691,748 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1348,691,655 - 48,691,748 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381348,538,179 - 48,538,272 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1348,538,179 - 48,538,272 (-)Ensemblmm10GRCm38
MGSCv371348,633,548 - 48,633,641 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
Celera1349,628,126 - 49,628,219 (-)NCBICelera
Cytogenetic Map13A5NCBI
MIRLET7A-2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl343,465,667 - 43,465,758 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1343,465,667 - 43,465,758 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2344,864,433 - 44,864,524 (+)NCBISscrofa10.2Sscrofa10.2susScr3

miRNA Target Status (No longer updated)

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Vimrno-let-7a-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18258830

Predicted Targets
Summary Value
Count of predictions:4387
Count of gene targets:2685
Count of transcripts:2936
Interacting mature miRNAs:rno-let-7a-1-3p, rno-let-7a-5p
Prediction methods:Microtar, Miranda, Pita, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17143999106Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17926675540968173Rat
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17436005727233623Rat
8552966Pigfal18Plasma insulin-like growth factor 1 level QTL 188.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)171286094257860942Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17212084342054133Rat
1582224Epfw4Epididymal fat weight QTL 43.50.0058epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)17920650523859062Rat
1582225Bw67Body weight QTL 676.20.0001body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)17622199858177198Rat
1582226Bw64Body weight QTL 644.20.0017body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
9589151Insul30Insulin level QTL 308.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)171286094257860942Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131706603Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17473353449733534Rat
9589057Scfw6Subcutaneous fat weight QTL 68.620.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)171286094257860942Rat
1582208Kidm32Kidney mass QTL 323.90.0018kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17920650523859062Rat
9590154Scort9Serum corticosterone level QTL 923.570.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)171286094257860942Rat
9590088Insglur7Insulin/glucose ratio QTL 720.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)171286094257860942Rat
1549900Iddm20Insulin dependent diabetes mellitus QTL 203.7pancreas integrity trait (VT:0010560)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)17122181410Rat
1331720Rf43Renal function QTL 432.881kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)171553702528637951Rat
2317053Aia25Adjuvant induced arthritis QTL 252.69joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)171060469455604694Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17136045694Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171553702560531414Rat
7411666Foco31Food consumption QTL 3111.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)171286094257860942Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)17121499218Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17473353449733534Rat
1581553Pur14Proteinuria QTL 145.30.0001urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)17798524316523460Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17857434232199534Rat
1582258Bw76Body weight QTL 764.60.0005body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17138037084Rat
1582199Insul5Insulin level QTL 53.40.0119blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)17920650523859062Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17143999106Rat
2293648Bmd31Bone mineral density QTL 314.50.0001femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)17436005727233623Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17143999106Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)17212084322087569Rat
1582241Bw70Body weight QTL 704.60.0003body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
1582245Bw73Body weight QTL 734.60.0004body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122877318Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
1 8 11 42 27 27 9 18 9 1 66 39 32 9 31 18

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_031800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000053755
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1716,320,135 - 16,320,234 (+)Ensembl
mRatBN7.2 Ensembl1716,113,768 - 16,113,867 (+)Ensembl
Rnor_6.0 Ensembl1716,417,855 - 16,417,954 (+)Ensembl
RefSeq Acc Id: NR_031800
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81716,320,133 - 16,320,226 (+)NCBI
mRatBN7.21716,113,766 - 16,113,859 (+)NCBI
Rnor_6.01716,417,853 - 16,417,946 (+)NCBI
Rnor_5.01718,473,966 - 18,474,059 (+)NCBI
Celera1715,839,823 - 15,839,916 (+)NCBI
Sequence:
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325409 AgrOrtholog
BioCyc Gene G2FUF-9969 BioCyc
Ensembl Genes ENSRNOG00000035632 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000053755 ENTREZGENE
miRBase MI0000827 ENTREZGENE
NCBI Gene 100314213 ENTREZGENE
PhenoGen Mirlet7a1 PhenoGen
RatGTEx ENSRNOG00000035632 RatGTEx
RNAcentral URS000022B6DD RNACentral
  URS0000416056 RNACentral
  URS000075A505 RNACentral
  URS000075D20D RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-11-22 Mirlet7a1  microRNA let-7a-1  Mirlet7a-1  microRNA let-7a-1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-06-02 Mirlet7a-1  microRNA let-7a-1      Symbol and Name status set to provisional 70820 PROVISIONAL