Mir29a (microRNA 29a) - Rat Genome Database

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Gene: Mir29a (microRNA 29a) Rattus norvegicus
Analyze
Symbol: Mir29a
Name: microRNA 29a
RGD ID: 2325393
Description: Predicted to enable lncRNA binding activity; mRNA 3'-UTR binding activity; and mRNA base-pairing translational repressor activity. Involved in negative regulation of smoothened signaling pathway and vasodilation. Predicted to be located in cytoplasm and extracellular exosome. Predicted to be part of RISC complex. Used to study diabetes mellitus. Biomarker of peptic esophagitis. Orthologous to human MIR29A (microRNA 29a); INTERACTS WITH 3,7-dihydropurine-6-thione; aflatoxin B1; aldehydo-D-glucose.
Type: ncrna
RefSeq Status: PROVISIONAL
Previously known as: rno-mir-29a
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8460,617,955 - 60,618,042 (-)NCBIGRCr8
mRatBN7.2459,650,608 - 59,650,695 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx464,621,101 - 64,621,188 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0460,537,282 - 60,537,369 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0458,939,224 - 58,939,311 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0458,343,931 - 58,344,018 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0458,099,674 - 58,099,761 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera454,744,230 - 54,744,317 (-)NCBICelera
Cytogenetic Map4q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to leukemia inhibitory factor  (ISO)
cellular response to lipopolysaccharide  (ISO)
epigenetic regulation of gene expression  (ISO)
long-term synaptic potentiation  (ISO)
miRNA-mediated gene silencing by inhibition of translation  (ISO)
miRNA-mediated post-transcriptional gene silencing  (ISO)
negative regulation of amyloid precursor protein catabolic process  (ISO)
negative regulation of amyloid-beta formation  (ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of circulating fibrinogen levels  (ISO)
negative regulation of collagen biosynthetic process  (ISO)
negative regulation of G1/S transition of mitotic cell cycle  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
negative regulation of smoothened signaling pathway  (IDA)
positive regulation of angiogenesis  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of endothelial cell migration  (ISO)
positive regulation of epidermal growth factor receptor signaling pathway  (ISO)
positive regulation of G1/S transition of mitotic cell cycle  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of mitochondrial membrane permeability involved in apoptotic process  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of vascular endothelial cell proliferation  (ISO)
positive regulation of wound healing  (ISO)
sensory perception of sound  (ISO)
tissue remodeling  (ISO)
vasodilation  (IMP)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Assessment of Cell-Free Long Non-Coding RNA-H19 and miRNA-29a, miRNA-29b Expression and Severity of Diabetes. Alfaifi M, etal., Diabetes Metab Syndr Obes. 2020 Oct 14;13:3727-3737. doi: 10.2147/DMSO.S273586. eCollection 2020.
2. LncRNA H19 Drives Proliferation of Cardiac Fibroblasts and Collagen Production via Suppression of the miR-29a-3p/miR-29b-3p-VEGFA/TGF-β Axis. Guo F, etal., Mol Cells. 2022 Mar 31;45(3):122-133. doi: 10.14348/molcells.2021.0066.
3. microRNA-9 and -29a regulate the progression of diabetic peripheral neuropathy via ISL1-mediated sonic hedgehog signaling pathway. Sun Q, etal., Aging (Albany NY). 2020 Jun 16;12(12):11446-11465. doi: 10.18632/aging.103230. Epub 2020 Jun 16.
4. Expression of Serum Exosomal and Esophageal MicroRNA in Rat Reflux Esophagitis. Uemura R, etal., Int J Mol Sci. 2017 Jul 25;18(8). pii: ijms18081611. doi: 10.3390/ijms18081611.
5. miR-29 contributes to normal endothelial function and can restore it in cardiometabolic disorders. Widlansky ME, etal., EMBO Mol Med. 2018 Mar;10(3). pii: emmm.201708046. doi: 10.15252/emmm.201708046.
6. MicroRNA-29a-5p is a novel predictor for early recurrence of hepatitis B virus-related hepatocellular carcinoma after surgical resection. Zhu HT, etal., PLoS One. 2012;7(12):e52393. doi: 10.1371/journal.pone.0052393. Epub 2012 Dec 20.
Additional References at PubMed
PMID:14691248   PMID:15345052   PMID:16381832   PMID:16766679   PMID:17604727   PMID:19170179   PMID:20403161   PMID:20734245   PMID:22095944   PMID:22194605   PMID:22565577   PMID:22940552  
PMID:22995515   PMID:23111009   PMID:23587482   PMID:23951316   PMID:24038396   PMID:24103556   PMID:24528955   PMID:24659628   PMID:24841827   PMID:25156787   PMID:25231273   PMID:25421979  
PMID:25665754   PMID:26700017   PMID:26936652   PMID:26992639   PMID:27239114   PMID:27501468   PMID:27910161   PMID:28000044   PMID:28315330   PMID:28404597   PMID:29409329   PMID:30173324  
PMID:30628716   PMID:31168988   PMID:31257508   PMID:31513704   PMID:31858562   PMID:31885334   PMID:31945680   PMID:32016990   PMID:32297569   PMID:32468029   PMID:32776916   PMID:32889668  
PMID:32964992   PMID:33066952   PMID:33571516   PMID:33620674   PMID:33761588   PMID:33945189   PMID:34519914   PMID:34837628   PMID:35016888   PMID:35274138   PMID:35720183   PMID:35833537  
PMID:36328430   PMID:36495508   PMID:36694058   PMID:37178498   PMID:38085146   PMID:38095165   PMID:39056770  


Genomics

Comparative Map Data
Mir29a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8460,617,955 - 60,618,042 (-)NCBIGRCr8
mRatBN7.2459,650,608 - 59,650,695 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx464,621,101 - 64,621,188 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0460,537,282 - 60,537,369 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0458,939,224 - 58,939,311 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0458,343,931 - 58,344,018 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0458,099,674 - 58,099,761 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera454,744,230 - 54,744,317 (-)NCBICelera
Cytogenetic Map4q22NCBI
MIR29A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387130,876,747 - 130,876,810 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7130,876,747 - 130,876,810 (-)EnsemblGRCh38hg38GRCh38
GRCh377130,561,506 - 130,561,569 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367130,212,045 - 130,212,108 (-)NCBINCBI36Build 36hg18NCBI36
Celera7125,312,587 - 125,312,650 (-)NCBICelera
Cytogenetic Map7q32.3NCBI
HuRef7124,876,998 - 124,877,061 (-)NCBIHuRef
CHM1_17130,495,162 - 130,495,225 (-)NCBICHM1_1
T2T-CHM13v2.07132,194,239 - 132,194,302 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27129,901,214 - 129,901,277 (-)NCBI
Mir29a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39631,039,595 - 31,039,682 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl631,039,595 - 31,039,682 (-)EnsemblGRCm39 Ensembl
GRCm38631,062,660 - 31,062,747 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl631,062,660 - 31,062,747 (-)EnsemblGRCm38mm10GRCm38
MGSCv37631,012,660 - 31,012,747 (-)NCBIGRCm37MGSCv37mm9NCBIm37
Celera631,048,423 - 31,048,510 (-)NCBICelera
Cytogenetic Map6A3.3NCBI
cM Map612.55NCBI
MIR29A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1146,184,844 - 6,184,903 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl146,184,830 - 6,184,916 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha145,845,114 - 5,845,173 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0145,919,035 - 5,919,094 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1146,124,590 - 6,124,649 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0145,869,856 - 5,869,915 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0146,013,045 - 6,013,104 (+)NCBIUU_Cfam_GSD_1.0
MIR29A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1818,040,032 - 18,040,118 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11818,040,032 - 18,040,117 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21819,035,225 - 19,035,310 (+)NCBISscrofa10.2Sscrofa10.2susScr3

miRNA Target Status (No longer updated)

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Stx1arno-miR-29a-3pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18258830
Cav2rno-miR-29a-3pMirtarbaseexternal_infoImmunoprecipitaion//Luciferase reporter assay//MicFunctional MTI17652184
Pmp22rno-miR-29a-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI19170179
Mcl1rno-miR-29a-3pMirtarbaseexternal_infoWestern blotFunctional MTI20164119
Smad4rno-miR-29a-3pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//Northern blFunctional MTI22506032

Predicted Targets
Summary Value
Count of predictions:8644
Count of gene targets:5473
Count of transcripts:5926
Interacting mature miRNAs:rno-miR-29a-3p, rno-miR-29a-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41564430960644309Rat
5685012Bmd87Bone mineral density QTL 875.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)43511329080113290Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)439431983123203361Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)459753119104753119Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44140057786400577Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44442502489425024Rat
5685009Bmd86Bone mineral density QTL 863.7tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)457613242102613242Rat
1331807Rf31Renal function QTL 312.988urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)44049044275726188Rat
634311Sach7Saccharin preference QTL 7taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)45807987582597589Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)458817672103817672Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41170660492690519Rat
61336Bp21Blood pressure QTL 214.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45808014680212111Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41890069763900697Rat
2312569Pur19Proteinuria QTL 193.40.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)459836842104836842Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)43726957782269577Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)427862204126119996Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
61475Aia2Adjuvant induced arthritis QTL 25.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)44047145375939996Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44140060386400603Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)42228845363245191Rat
8552807Vie4Viral induced encephalitis QTL 47.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)41890069763900697Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)43044896182336920Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42786220462997402Rat
1558651Swd3Spike wave discharge measurement QTL 34.620.000024brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)44140057786400577Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)42192515166925151Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)457664252127749483Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)4163900697Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)451085655113588029Rat
631546Bp86Blood pressure QTL 863.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45807987592690793Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)440490442117737312Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)457613339151163960Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)433538597116185060Rat
4889969Bss96Bone structure and strength QTL 964.9tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)457613242102613242Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
4889972Bss97Bone structure and strength QTL 975.6tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)457613242102613242Rat
631671Iddm11Insulin dependent diabetes mellitus QTL 113.60.0012blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)45960331980216952Rat


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NR_031836 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: NR_031836
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8460,617,955 - 60,618,042 (-)NCBI
mRatBN7.2459,650,608 - 59,650,695 (-)NCBI
Rnor_6.0458,343,931 - 58,344,018 (-)NCBI
Rnor_5.0458,099,674 - 58,099,761 (-)NCBI
Celera454,744,230 - 54,744,317 (-)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
BioCyc Gene G2FUF-45322 BioCyc
miRBase MI0000863 ENTREZGENE
NCBI Gene 100314230 ENTREZGENE
PhenoGen Mir29a PhenoGen
RNAcentral URS0000076995 RNACentral
  URS00002F4D78 RNACentral
  URS000075D2D5 RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-04-09 Mir29a  microRNA 29a  Mir29a  microRNA mir-29a  Name updated 61478 APPROVED
2010-06-02 Mir29a  microRNA mir-29a      Symbol and Name status set to provisional 70820 PROVISIONAL