Mir181c (microRNA 181c) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Mir181c (microRNA 181c) Rattus norvegicus
Analyze
Symbol: Mir181c
Name: microRNA 181c
RGD ID: 2325381
Description: Predicted to enable mRNA base-pairing translational repressor activity and single-stranded RNA binding activity. Predicted to be involved in miRNA-mediated gene silencing by inhibition of translation; miRNA-mediated gene silencing by mRNA destabilization; and negative regulation of inflammatory response. Predicted to act upstream of or within several processes, including cellular response to leukemia inhibitory factor; hematopoietic stem cell differentiation; and long-term synaptic potentiation. Predicted to be part of RISC complex. Biomarker of hepatitis C and hepatocellular carcinoma. Orthologous to human MIR181C (microRNA 181c); INTERACTS WITH 2-acetamidofluorene; atrazine; bleomycin A2.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: microRNA mir-181c; rno-mir-181c
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81940,888,291 - 40,888,396 (+)NCBIGRCr8
GRCr8 Ensembl1940,888,291 - 40,888,396 (+)EnsemblGRCr8 Ensembl
mRatBN7.21923,983,523 - 23,983,628 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1923,983,523 - 23,983,628 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1930,804,354 - 30,804,459 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01931,458,768 - 31,458,873 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01933,681,521 - 33,681,626 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01925,290,211 - 25,290,316 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1925,290,211 - 25,290,316 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01936,267,311 - 36,267,416 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1923,532,066 - 23,532,171 (+)NCBICelera
Cytogenetic Map19q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
RISC complex  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. MicroRNA‑181c suppresses growth and metastasis of hepatocellular carcinoma by modulating NCAPG. Ai J, etal., Cancer Manag Res. 2019 Apr 23;11:3455-3467. doi: 10.2147/CMAR.S197716. eCollection 2019.
2. Transcriptional suppression of miR-181c by hepatitis C virus enhances homeobox A1 expression. Mukherjee A, etal., J Virol. 2014 Jul;88(14):7929-40. doi: 10.1128/JVI.00787-14. Epub 2014 Apr 30.
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16381832   PMID:17604727   PMID:18762567   PMID:20403161   PMID:20439489   PMID:20660734   PMID:21247879   PMID:22518031   PMID:23185045   PMID:23390484   PMID:23646144   PMID:24810628  
PMID:25545945   PMID:25858512   PMID:25986729   PMID:28770951   PMID:30974824   PMID:31172560   PMID:31466503   PMID:35906351   PMID:36227355  


Genomics

Comparative Map Data
Mir181c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81940,888,291 - 40,888,396 (+)NCBIGRCr8
GRCr8 Ensembl1940,888,291 - 40,888,396 (+)EnsemblGRCr8 Ensembl
mRatBN7.21923,983,523 - 23,983,628 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1923,983,523 - 23,983,628 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1930,804,354 - 30,804,459 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01931,458,768 - 31,458,873 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01933,681,521 - 33,681,626 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01925,290,211 - 25,290,316 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1925,290,211 - 25,290,316 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01936,267,311 - 36,267,416 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1923,532,066 - 23,532,171 (+)NCBICelera
Cytogenetic Map19q11NCBI
MIR181C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381913,874,699 - 13,874,808 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1913,874,699 - 13,874,808 (+)EnsemblGRCh38hg38GRCh38
GRCh371913,985,513 - 13,985,622 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361913,846,512 - 13,846,621 (+)NCBINCBI36Build 36hg18NCBI36
Celera1913,879,258 - 13,879,367 (+)NCBICelera
Cytogenetic Map19p13.12NCBI
HuRef1913,556,824 - 13,556,933 (+)NCBIHuRef
CHM1_11913,986,209 - 13,986,318 (+)NCBICHM1_1
T2T-CHM13v2.01914,000,855 - 14,000,964 (+)NCBIT2T-CHM13v2.0
Mir181c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39884,905,502 - 84,905,590 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl884,905,502 - 84,905,590 (-)EnsemblGRCm39 Ensembl
GRCm38884,178,873 - 84,178,961 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl884,178,873 - 84,178,961 (-)EnsemblGRCm38mm10GRCm38
MGSCv37886,702,772 - 86,702,860 (-)NCBIGRCm37MGSCv37mm9NCBIm37
Celera888,479,316 - 88,479,404 (-)NCBICelera
Cytogenetic Map8C2NCBI
cM Map840.47NCBI
MIR181C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12048,593,343 - 48,593,403 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2048,593,325 - 48,593,421 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2048,467,392 - 48,467,452 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02049,111,581 - 49,111,641 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2049,111,563 - 49,111,659 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12048,322,079 - 48,322,139 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02048,748,988 - 48,749,048 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02048,992,042 - 48,992,102 (-)NCBIUU_Cfam_GSD_1.0
MIR181C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl265,279,944 - 65,280,040 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1265,279,950 - 65,280,036 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2265,553,664 - 65,553,750 (-)NCBISscrofa10.2Sscrofa10.2susScr3

miRNA Target Status (No longer updated)

Predicted Targets
Summary Value
Count of predictions:4045
Count of gene targets:3039
Count of transcripts:3241
Interacting mature miRNAs:rno-miR-181c-3p, rno-miR-181c-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19799775052997750Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)191922068964220689Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19799775052997750Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032907674246245Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)19574806450748064Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)193236531174246245Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)192409397369093973Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191083361874246245Rat
2303628Vencon9Ventilatory control QTL 90.005respiration trait (VT:0001943)minute ventilation (CMO:0000132)192318858668188586Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)193253961574246245Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)193128753251431640Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19799775052997750Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19799775052997750Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)193177788874246245Rat
1554318Bmd5Bone mineral density QTL 512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)192318858668188586Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)192010930665109306Rat
1354607Gmadr1Adrenal mass QTL 15.83adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)194072709254856850Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
1354600Salc2Saline consumption QTL 29.910.001drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)194072709254856850Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat
1354633Bw28Body weight QTL 286.04body mass (VT:0001259)body weight (CMO:0000012)194072709254856850Rat
61407Scl12Serum cholesterol level QTL 120.001blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)193009938347207961Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
1 2 14 78 16 14 12 2 59 34 69 22 32 14

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_031897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000053692
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1940,888,291 - 40,888,396 (+)Ensembl
mRatBN7.2 Ensembl1923,983,523 - 23,983,628 (+)Ensembl
Rnor_6.0 Ensembl1925,290,211 - 25,290,316 (-)Ensembl
RefSeq Acc Id: NR_031897
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81940,888,291 - 40,888,396 (+)NCBI
mRatBN7.21923,983,523 - 23,983,628 (+)NCBI
Rnor_6.01925,290,211 - 25,290,316 (-)NCBI
Rnor_5.01936,267,311 - 36,267,416 (-)NCBI
Celera1923,532,066 - 23,532,171 (+)NCBI
Sequence:
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325381 AgrOrtholog
BioCyc Gene G2FUF-6070 BioCyc
Ensembl Genes ENSRNOG00000035569 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000053692 ENTREZGENE
miRBase MI0000924 ENTREZGENE
NCBI Gene 100314242 ENTREZGENE
PhenoGen Mir181c PhenoGen
RatGTEx ENSRNOG00000035569 RatGTEx
RNAcentral URS000018C928 RNACentral
  URS00005AF7FD RNACentral
  URS000075BB13 RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-14 Mir181c  microRNA 181c  Mir181c  microRNA mir-181c  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-06-02 Mir181c  microRNA mir-181c      Symbol and Name status set to provisional 70820 PROVISIONAL