Ankdd1b (ankyrin repeat and death domain containing 1B) - Rat Genome Database

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Gene: Ankdd1b (ankyrin repeat and death domain containing 1B) Rattus norvegicus
Analyze
Symbol: Ankdd1b
Name: ankyrin repeat and death domain containing 1B
RGD ID: 2325067
Description: Predicted to be involved in signal transduction. Orthologous to human ANKDD1B (ankyrin repeat and death domain containing 1B); INTERACTS WITH trichloroethene; 17beta-estradiol (ortholog); 4-hydroxyphenyl retinamide (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ankyrin repeat and death domain-containing protein 1B; LOC100359662
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2227,750,301 - 27,814,291 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl227,750,987 - 27,813,734 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0227,030,295 - 27,297,045 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl227,246,319 - 27,296,777 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0246,153,194 - 46,160,267 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0246,359,579 - 46,408,326 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4226,879,464 - 26,933,141 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera223,796,173 - 23,859,999 (-)NCBICelera
Cytogenetic Map2q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Ankdd1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2227,750,301 - 27,814,291 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl227,750,987 - 27,813,734 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0227,030,295 - 27,297,045 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl227,246,319 - 27,296,777 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0246,153,194 - 46,160,267 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0246,359,579 - 46,408,326 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4226,879,464 - 26,933,141 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera223,796,173 - 23,859,999 (-)NCBICelera
Cytogenetic Map2q12NCBI
ANKDD1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38575,611,453 - 75,671,846 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl575,611,182 - 75,681,773 (+)EnsemblGRCh38hg38GRCh38
GRCh37574,907,278 - 74,967,671 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36574,934,498 - 75,001,205 (+)NCBINCBI36Build 36hg18NCBI36
Celera570,800,866 - 70,858,526 (+)NCBICelera
Cytogenetic Map5q13.3NCBI
HuRef570,112,437 - 70,172,701 (+)NCBIHuRef
CHM1_1574,340,017 - 74,400,375 (+)NCBICHM1_1
T2T-CHM13v2.0576,092,523 - 76,152,917 (+)NCBIT2T-CHM13v2.0
Ankdd1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391396,552,642 - 96,607,766 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1396,552,642 - 96,607,775 (-)EnsemblGRCm39 Ensembl
GRCm381396,416,134 - 96,471,258 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1396,416,134 - 96,471,267 (-)EnsemblGRCm38mm10GRCm38
MGSCv371397,186,089 - 97,241,115 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361397,186,089 - 97,241,115 (-)NCBIMGSCv36mm8
Celera13100,050,040 - 100,108,335 (-)NCBICelera
Cytogenetic Map13D1NCBI
Ankdd1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542525,095,890 - 25,153,960 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542525,094,742 - 25,154,497 (-)NCBIChiLan1.0ChiLan1.0
ANKDD1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1540,246,540 - 40,300,787 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl540,246,540 - 40,300,787 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0539,631,584 - 39,689,888 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
Ankdd1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213189,672,941 - 189,744,201 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365491,115,661 - 1,185,726 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365491,114,990 - 1,185,910 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ANKDD1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl284,621,148 - 84,688,222 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1284,621,096 - 84,689,819 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2286,257,241 - 86,333,194 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ANKDD1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1469,941,672 - 69,996,351 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604918,725,453 - 18,781,971 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ankdd1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249052,713,284 - 2,789,301 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249052,713,174 - 2,789,670 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ankdd1b
350 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:103
Count of miRNA genes:86
Interacting mature miRNAs:91
Transcripts:ENSRNOT00000034041
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631682Bp115Blood pressure QTL 1154.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2137410502Rat
738010Lnnr3Liver neoplastic nodule remodeling QTL 32.94liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)2141244106Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
1600379Mcs18Mammary carcinoma susceptibility QTL 182.6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2788777242804738Rat
738012Anxrr3Anxiety related response QTL 33.8exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)2902351954023519Rat
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)21185206249003364Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat
10402051Gdil2Gastrointestinal dilation QTL 2enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)22490385374786777Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22691781781754745Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
1331764Bp205Blood pressure QTL 2053.476arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)22699957143154682Rat
1643006Pain1Pain QTL 13.630.005mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)22699957148268661Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22715716072157160Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 1 1 5 11 18
Below cutoff 2 31 31 22 16 22 1 1 20 24 18 10 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000034041   ⟹   ENSRNOP00000032365
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl227,750,987 - 27,813,734 (-)Ensembl
Rnor_6.0 Ensembl227,246,334 - 27,287,605 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000080748   ⟹   ENSRNOP00000068543
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl227,750,987 - 27,813,734 (-)Ensembl
Rnor_6.0 Ensembl227,246,319 - 27,296,777 (-)Ensembl
RefSeq Acc Id: XM_008760686   ⟹   XP_008758908
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2227,750,301 - 27,814,291 (-)NCBI
Rnor_6.0227,030,295 - 27,297,045 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039103459   ⟹   XP_038959387
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2227,750,301 - 27,813,302 (-)NCBI
RefSeq Acc Id: XM_039103460   ⟹   XP_038959388
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2227,762,678 - 27,813,305 (-)NCBI
RefSeq Acc Id: XM_039103461   ⟹   XP_038959389
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2227,754,165 - 27,813,305 (-)NCBI
RefSeq Acc Id: XM_039103462   ⟹   XP_038959390
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2227,750,301 - 27,801,680 (-)NCBI
Reference Sequences
RefSeq Acc Id: XP_008758908   ⟸   XM_008760686
- Peptide Label: isoform X5
- UniProtKB: F1M363 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000068543   ⟸   ENSRNOT00000080748
RefSeq Acc Id: ENSRNOP00000032365   ⟸   ENSRNOT00000034041
RefSeq Acc Id: XP_038959387   ⟸   XM_039103459
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038959390   ⟸   XM_039103462
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038959389   ⟸   XM_039103461
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038959388   ⟸   XM_039103460
- Peptide Label: isoform X2
Protein Domains
Death

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JT24-F1-model_v2 AlphaFold A0A0G2JT24 1-394 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325067 AgrOrtholog
BioCyc Gene G2FUF-54780 BioCyc
Ensembl Genes ENSRNOG00000025377 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000032365 ENTREZGENE
  ENSRNOP00000032365.7 UniProtKB/TrEMBL
  ENSRNOP00000068543.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000034041 ENTREZGENE
  ENSRNOT00000034041.7 UniProtKB/TrEMBL
  ENSRNOT00000080748.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
  1.25.40.20 UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  DEATH-like_dom_sf UniProtKB/TrEMBL
  Death_domain UniProtKB/TrEMBL
NCBI Gene 100359662 ENTREZGENE
Pfam Ank UniProtKB/TrEMBL
  Ank_2 UniProtKB/TrEMBL
PhenoGen Ankdd1b PhenoGen
PRINTS ANKYRIN UniProtKB/TrEMBL
PROSITE ANK_REPEAT UniProtKB/TrEMBL
  DEATH_DOMAIN UniProtKB/TrEMBL
SMART ANK UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/TrEMBL
  SSF48403 UniProtKB/TrEMBL
UniProt A0A0G2JT24_RAT UniProtKB/TrEMBL
  F1M363 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-07-24 Ankdd1b  ankyrin repeat and death domain containing 1B  LOC100359662  ankyrin repeat and death domain containing 1B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-20 LOC100359662  ankyrin repeat and death domain containing 1B      Symbol and Name status set to provisional 70820 PROVISIONAL