Yy2 (YY2 transcription factor) - Rat Genome Database

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Gene: Yy2 (YY2 transcription factor) Rattus norvegicus
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Symbol: Yy2
Name: YY2 transcription factor
RGD ID: 2324567
Description: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in chromatin and nucleus. Predicted to be part of PcG protein complex and transcription regulator complex. Orthologous to human YY2 (YY2 transcription factor); INTERACTS WITH 1,2-dichloroethane (ortholog); 1,2-dimethylhydrazine (ortholog); 2,3,7,8-tetrachlorodibenzodioxine (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC100361836; Transcription factor YY2; Transcription factor YY2-like; Yin and yang 2; YY-2
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X41,253,481 - 41,257,103 (+)NCBIGRCr8
mRatBN7.2X37,438,425 - 37,442,047 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX37,410,811 - 37,464,430 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX38,637,085 - 38,640,706 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X42,104,280 - 42,107,901 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X39,788,991 - 39,792,612 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X40,285,923 - 40,289,545 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
RGSC_v3.4X58,737,493 - 58,738,623 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX38,066,476 - 38,070,098 (+)NCBICelera
Cytogenetic MapXq21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15057822   PMID:15087442   PMID:16260628   PMID:23332764  


Genomics

Comparative Map Data
Yy2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X41,253,481 - 41,257,103 (+)NCBIGRCr8
mRatBN7.2X37,438,425 - 37,442,047 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX37,410,811 - 37,464,430 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX38,637,085 - 38,640,706 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X42,104,280 - 42,107,901 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X39,788,991 - 39,792,612 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X40,285,923 - 40,289,545 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
RGSC_v3.4X58,737,493 - 58,738,623 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX38,066,476 - 38,070,098 (+)NCBICelera
Cytogenetic MapXq21NCBI
YY2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X21,855,987 - 21,858,740 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX21,855,987 - 21,858,740 (+)EnsemblGRCh38hg38GRCh38
GRCh37X21,874,105 - 21,876,858 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X21,784,524 - 21,785,642 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X21,634,259 - 21,635,378NCBI
CeleraX25,995,801 - 25,998,522 (+)NCBICelera
Cytogenetic MapXp22.12NCBI
HuRefX19,615,092 - 19,617,813 (+)NCBIHuRef
CHM1_1X21,904,524 - 21,907,264 (+)NCBICHM1_1
T2T-CHM13v2.0X21,439,288 - 21,442,041 (+)NCBIT2T-CHM13v2.0
Yy2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X156,349,115 - 156,351,981 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX156,349,115 - 156,351,981 (-)EnsemblGRCm39 Ensembl
GRCm38X157,566,119 - 157,568,985 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX157,566,119 - 157,568,985 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X154,004,051 - 154,006,917 (-)NCBIGRCm37MGSCv37mm9NCBIm37
CeleraX140,818,791 - 140,821,630 (-)NCBICelera
Cytogenetic MapXF4NCBI
cM MapX72.57NCBI
YY2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X23,662,228 - 23,677,032 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X23,665,506 - 23,680,423 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X14,486,444 - 14,489,457 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X21,842,676 - 21,844,949 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX21,842,693 - 21,843,812 (+)Ensemblpanpan1.1panPan2
YY2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X17,672,528 - 17,676,552 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0X17,632,553 - 17,636,290 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1X17,666,733 - 17,669,609 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X17,688,471 - 17,692,205 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X17,748,713 - 17,752,450 (+)NCBIUU_Cfam_GSD_1.0
Yy2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X10,667,817 - 10,670,212 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366242,487,983 - 2,489,630 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
YY2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X20,337,022 - 20,338,701 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605622,189,608 - 22,192,528 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Yy2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248296,811,644 - 6,815,253 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Yy2
3 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598873Memor2Memory QTL 22.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)X2099094741052531Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
2290375Gluco34Glucose level QTL 342.75blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X2099094741203591Rat
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat
71116Niddm16Non-insulin dependent diabetes mellitus QTL 167.81blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X1529780260297802Rat

Markers in Region
UniSTS:530593  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X37,439,829 - 37,440,033 (+)MAPPERmRatBN7.2
Rnor_6.0X40,287,328 - 40,287,531NCBIRnor6.0
Rnor_5.0X40,597,615 - 40,597,818UniSTSRnor5.0
RGSC_v3.4X58,737,996 - 58,738,199UniSTSRGSC3.4
CeleraX38,067,881 - 38,068,084UniSTS
Cytogenetic MapXq21UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSRNOT00000033010   ⟹   ENSRNOP00000031616
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX37,410,919 - 37,464,430 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000087898   ⟹   ENSRNOP00000071961
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX37,439,094 - 37,458,619 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099895   ⟹   ENSRNOP00000081160
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX37,410,919 - 37,442,047 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000105689   ⟹   ENSRNOP00000078442
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX37,410,811 - 37,442,047 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108352   ⟹   ENSRNOP00000095286
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX37,410,927 - 37,458,619 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110665   ⟹   ENSRNOP00000087347
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX37,410,919 - 37,438,974 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117269   ⟹   ENSRNOP00000089986
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX37,410,907 - 37,442,047 (+)Ensembl
RefSeq Acc Id: NM_001377233   ⟹   NP_001364162
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X41,253,481 - 41,257,103 (+)NCBI
mRatBN7.2X37,438,425 - 37,442,047 (+)NCBI
RefSeq Acc Id: NP_001364162   ⟸   NM_001377233
- UniProtKB: P0C6P6 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000089986   ⟸   ENSRNOT00000117269
Ensembl Acc Id: ENSRNOP00000087347   ⟸   ENSRNOT00000110665
Ensembl Acc Id: ENSRNOP00000095286   ⟸   ENSRNOT00000108352
Ensembl Acc Id: ENSRNOP00000071961   ⟸   ENSRNOT00000087898
Ensembl Acc Id: ENSRNOP00000081160   ⟸   ENSRNOT00000099895
Ensembl Acc Id: ENSRNOP00000031616   ⟸   ENSRNOT00000033010
Ensembl Acc Id: ENSRNOP00000078442   ⟸   ENSRNOT00000105689
Protein Domains
Peptidase M50

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P0C6P6-F1-model_v2 AlphaFold P0C6P6 1-376 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2324567 AgrOrtholog
BioCyc Gene G2FUF-2465 BioCyc
Ensembl Genes ENSRNOG00000007644 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055014763 UniProtKB/Swiss-Prot
  ENSRNOG00060019925 UniProtKB/Swiss-Prot
  ENSRNOG00065013111 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000087898.2 UniProtKB/TrEMBL
  ENSRNOT00000099895.1 UniProtKB/Swiss-Prot
  ENSRNOT00000105689.1 UniProtKB/Swiss-Prot
  ENSRNOT00000110665.1 UniProtKB/TrEMBL
  ENSRNOT00000117269.1 UniProtKB/Swiss-Prot
  ENSRNOT00055025274 UniProtKB/Swiss-Prot
  ENSRNOT00055025280 UniProtKB/Swiss-Prot
  ENSRNOT00060034415 UniProtKB/Swiss-Prot
  ENSRNOT00060034425 UniProtKB/Swiss-Prot
  ENSRNOT00065021491 UniProtKB/Swiss-Prot
  ENSRNOT00065021495 UniProtKB/Swiss-Prot
Gene3D-CATH 2.30.42.10 UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/Swiss-Prot
InterPro MBTPS2 UniProtKB/TrEMBL
  PDZ_sf UniProtKB/TrEMBL
  Peptidase_M50 UniProtKB/TrEMBL
  YY-1-like UniProtKB/Swiss-Prot
  Znf_C2H2_sf UniProtKB/Swiss-Prot
  Znf_C2H2_type UniProtKB/Swiss-Prot
NCBI Gene Yy2 ENTREZGENE
PANTHER MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE-2 PROTEASE UniProtKB/TrEMBL
  PTHR13325 UniProtKB/TrEMBL
  TRANSCRIPTION FACTOR YY2 UniProtKB/Swiss-Prot
  TRANSCRIPTIONAL REPRESSOR PROTEIN YY UniProtKB/Swiss-Prot
Pfam Peptidase_M50 UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/Swiss-Prot
PhenoGen Yy2 PhenoGen
PIRSF TF_Yin_yang UniProtKB/Swiss-Prot
PRINTS SREBPS2PTASE UniProtKB/TrEMBL
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/Swiss-Prot
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000007644 RatGTEx
  ENSRNOG00055014763 RatGTEx
  ENSRNOG00060019925 RatGTEx
  ENSRNOG00065013111 RatGTEx
SMART ZnF_C2H2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50156 UniProtKB/TrEMBL
  SSF57667 UniProtKB/Swiss-Prot
UniProt A0A0G2K1S2_RAT UniProtKB/TrEMBL
  A0A8I6A7T1_RAT UniProtKB/TrEMBL
  P0C6P6 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-08-22 Yy2  YY2 transcription factor  LOC100361836  Transcription factor YY2-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-06 LOC100361836  Transcription factor YY2-like      Symbol and Name status set to provisional 70820 PROVISIONAL