Ap1g2 (adaptor related protein complex 1 subunit gamma 2) - Rat Genome Database

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Gene: Ap1g2 (adaptor related protein complex 1 subunit gamma 2) Rattus norvegicus
Analyze
Symbol: Ap1g2 (Ensembl: Jph4)
Name: adaptor related protein complex 1 subunit gamma 2 (Ensembl:junctophilin 4)
RGD ID: 2324507
Description: Predicted to enable clathrin adaptor activity. Predicted to be involved in Golgi to vacuole transport. Predicted to act upstream of or within several processes, including learning; neuromuscular process controlling balance; and regulation of store-operated calcium entry. Predicted to be located in Golgi-associated vesicle; membrane; and transport vesicle. Predicted to be part of AP-1 adaptor complex. Predicted to be active in synapse. Orthologous to human AP1G2 (adaptor related protein complex 1 subunit gamma 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; chlorpyrifos.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: adaptor protein complex AP-1, gamma 2 subunit; adaptor-related protein complex 1, gamma 2 subunit; AP-1 complex subunit gamma-like 2; LOC100362547
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81532,541,528 - 32,549,392 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1532,541,528 - 32,549,280 (-)EnsemblGRCr8
mRatBN7.21528,571,571 - 28,579,421 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1528,571,568 - 28,589,004 (-)EnsemblmRatBN7.2
Rnor_6.01533,759,108 - 33,767,017 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1533,759,001 - 33,766,438 (-)Ensemblrn6Rnor6.0
Rnor_5.01537,646,196 - 37,654,142 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41533,205,056 - 33,212,801 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1528,149,554 - 28,157,463 (-)NCBICelera
Cytogenetic Map15p13NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9733768   PMID:9762922   PMID:10477754  


Genomics

Comparative Map Data
Ap1g2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81532,541,528 - 32,549,392 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1532,541,528 - 32,549,280 (-)EnsemblGRCr8
mRatBN7.21528,571,571 - 28,579,421 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1528,571,568 - 28,589,004 (-)EnsemblmRatBN7.2
Rnor_6.01533,759,108 - 33,767,017 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1533,759,001 - 33,766,438 (-)Ensemblrn6Rnor6.0
Rnor_5.01537,646,196 - 37,654,142 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41533,205,056 - 33,212,801 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1528,149,554 - 28,157,463 (-)NCBICelera
Cytogenetic Map15p13NCBI
AP1G2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381423,559,567 - 23,567,791 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1423,559,565 - 23,568,070 (-)Ensemblhg38GRCh38
GRCh371424,028,776 - 24,037,000 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361423,098,616 - 23,107,119 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341423,098,616 - 23,107,119NCBI
Celera143,891,447 - 3,899,947 (-)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef144,145,296 - 4,153,793 (-)NCBIHuRef
CHM1_11424,027,437 - 24,035,928 (-)NCBICHM1_1
T2T-CHM13v2.01417,760,126 - 17,768,361 (-)NCBIT2T-CHM13v2.0
Ap1g2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391455,336,292 - 55,344,050 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1455,336,032 - 55,344,050 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381455,098,835 - 55,106,593 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1455,098,575 - 55,106,593 (-)Ensemblmm10GRCm38
MGSCv371455,717,687 - 55,725,430 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361454,052,926 - 54,060,218 (-)NCBIMGSCv36mm8
Celera1452,904,747 - 52,912,490 (-)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1428.07NCBI
Ap1g2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540936,795,358 - 36,803,605 (+)Ensembl
ChiLan1.0NW_00495540936,795,351 - 36,803,605 (+)NCBIChiLan1.0ChiLan1.0
AP1G2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21524,990,582 - 24,998,331 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11424,207,074 - 24,215,379 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0144,378,017 - 4,386,319 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11422,471,343 - 22,479,606 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1422,471,343 - 22,479,801 (-)EnsemblpanPan2panpan1.1
AP1G2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.183,785,085 - 3,793,081 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl83,629,585 - 3,792,725 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha83,706,961 - 3,714,960 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.083,895,368 - 3,903,367 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl83,895,370 - 3,903,092 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.183,586,577 - 3,594,576 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.083,648,029 - 3,656,028 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.083,910,114 - 3,918,113 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ap1g2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864035,529,746 - 35,538,060 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936722851,917 - 859,052 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936722851,182 - 859,238 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AP1G2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl775,533,202 - 75,549,488 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1775,533,131 - 75,549,490 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2780,848,680 - 80,863,738 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AP1G2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12923,930,703 - 23,939,239 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2923,929,216 - 23,938,553 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605922,479,554 - 22,487,920 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ap1g2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248209,011,345 - 9,019,487 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248209,011,251 - 9,019,487 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Ap1g2
44 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:54
Count of miRNA genes:52
Interacting mature miRNAs:52
Transcripts:ENSRNOT00000033977
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15231575947315759Rat
5684946Bss98Bone structure and strength QTL 983.90.0026tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)15139411584Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15144836456Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)153185580392671517Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152272835342072050Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152852773273527732Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)152233635152597086Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15278592347785923Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151492659471614418Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)152233635167336351Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat

Markers in Region
RH131652  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21528,571,212 - 28,571,410 (+)MAPPERmRatBN7.2
Rnor_6.01533,758,750 - 33,758,947NCBIRnor6.0
Rnor_5.01537,645,835 - 37,646,032UniSTSRnor5.0
RGSC_v3.41533,204,698 - 33,204,895UniSTSRGSC3.4
Celera1528,149,196 - 28,149,393UniSTS
Cytogenetic Map15p13UniSTS
AI715271  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81532,541,561 - 32,541,834 (+)Marker Load Pipeline
mRatBN7.21528,571,604 - 28,571,877 (+)MAPPERmRatBN7.2
Rnor_6.01533,759,142 - 33,759,414NCBIRnor6.0
Rnor_5.01537,646,227 - 37,646,499UniSTSRnor5.0
RGSC_v3.41533,205,090 - 33,205,362UniSTSRGSC3.4
Celera1528,149,588 - 28,149,860UniSTS
RH 3.4 Map15260.21UniSTS
Cytogenetic Map15p13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 92 59 6 356 192 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000033722   ⟹   ENSRNOP00000099475
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1532,541,528 - 32,549,280 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000033977   ⟹   ENSRNOP00000036180
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1532,549,555 - 32,558,859 (-)Ensembl
mRatBN7.2 Ensembl1528,571,568 - 28,589,004 (-)Ensembl
Rnor_6.0 Ensembl1533,759,001 - 33,766,438 (-)Ensembl
RefSeq Acc Id: NM_001427245   ⟹   NP_001414174
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81532,541,528 - 32,549,280 (-)NCBI
RefSeq Acc Id: XM_039093834   ⟹   XP_038949762
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81532,544,517 - 32,549,392 (-)NCBI
mRatBN7.21528,574,561 - 28,579,421 (-)NCBI
RefSeq Acc Id: XM_063273889   ⟹   XP_063129959
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81532,541,531 - 32,548,787 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001414174 (Get FASTA)   NCBI Sequence Viewer  
  XP_038949762 (Get FASTA)   NCBI Sequence Viewer  
  XP_063129959 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000036180.4
  ENSRNOP00000099475
Ensembl Acc Id: ENSRNOP00000036180   ⟸   ENSRNOT00000033977
RefSeq Acc Id: XP_038949762   ⟸   XM_039093834
- Peptide Label: isoform X2
RefSeq Acc Id: NP_001414174   ⟸   NM_001427245
- UniProtKB: A6KGZ0 (UniProtKB/TrEMBL),   D3ZGW2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129959   ⟸   XM_063273889
- Peptide Label: isoform X1
- UniProtKB: A6KGY9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000099475   ⟸   ENSRNOT00000033722
Protein Domains
GAE

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZGW2-F1-model_v2 AlphaFold D3ZGW2 1-785 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2324507 AgrOrtholog
BioCyc Gene G2FUF-13741 BioCyc
Ensembl Genes ENSRNOG00000025589 Ensembl, ENTREZGENE
  ENSRNOG00000025619 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000033722 ENTREZGENE
  ENSRNOT00000033977.7 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/TrEMBL
  2.60.40.1230 UniProtKB/TrEMBL
InterPro Adaptor_Complx_Large_Subunit UniProtKB/TrEMBL
  AP1_complex_gsu UniProtKB/TrEMBL
  ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  Clathrin/coatomer_adapt-like_N UniProtKB/TrEMBL
  Clathrin/coatomer_app_Ig-like UniProtKB/TrEMBL
  Clathrin_a/b/g-adaptin_app_Ig UniProtKB/TrEMBL
  Clathrin_g-adaptin_app UniProtKB/TrEMBL
NCBI Gene 100362547 ENTREZGENE
PANTHER ADAPTIN, ALPHA/GAMMA/EPSILON UniProtKB/TrEMBL
Pfam Adaptin_N UniProtKB/TrEMBL
  Alpha_adaptinC2 UniProtKB/TrEMBL
PhenoGen Ap1g2 PhenoGen
PIRSF AP1_complex_gamma UniProtKB/TrEMBL
PROSITE GAE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000025589 RatGTEx
  ENSRNOG00000025619 RatGTEx
SMART Alpha_adaptinC2 UniProtKB/TrEMBL
Superfamily-SCOP ARM-type_fold UniProtKB/TrEMBL
  Clath_adapt UniProtKB/TrEMBL
UniProt A6KGY9 ENTREZGENE, UniProtKB/TrEMBL
  A6KGZ0 ENTREZGENE, UniProtKB/TrEMBL
  D3ZGW2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-03 Ap1g2  adaptor related protein complex 1 subunit gamma 2  Ap1g2  adaptor-related protein complex 1, gamma 2 subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-08-29 Ap1g2  adaptor-related protein complex 1, gamma 2 subunit  LOC100362547  adaptor protein complex AP-1, gamma 2 subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-06 LOC100362547  adaptor protein complex AP-1, gamma 2 subunit      Symbol and Name status set to provisional 70820 PROVISIONAL