Fam177a1 (family with sequence similarity 177, member A1) - Rat Genome Database

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Gene: Fam177a1 (family with sequence similarity 177, member A1) Rattus norvegicus
Analyze
Symbol: Fam177a1
Name: family with sequence similarity 177, member A1
RGD ID: 2323636
Description: Orthologous to human FAM177A1 (family with sequence similarity 177 member A1); INTERACTS WITH azoxystrobin; chlorpyrifos; glyphosate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC100359558; LOC100359558
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8678,367,780 - 78,382,703 (+)NCBIGRCr8
mRatBN7.2672,632,628 - 72,647,553 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl672,632,623 - 72,647,553 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx673,055,248 - 73,070,186 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0673,361,597 - 73,376,537 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0672,790,230 - 72,805,149 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0676,041,080 - 76,055,912 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl676,041,669 - 76,053,759 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0685,577,837 - 85,592,624 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4675,501,445 - 75,513,944 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera671,473,300 - 71,488,310 (+)NCBICelera
Cytogenetic Map6q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Fam177a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8678,367,780 - 78,382,703 (+)NCBIGRCr8
mRatBN7.2672,632,628 - 72,647,553 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl672,632,623 - 72,647,553 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx673,055,248 - 73,070,186 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0673,361,597 - 73,376,537 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0672,790,230 - 72,805,149 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0676,041,080 - 76,055,912 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl676,041,669 - 76,053,759 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0685,577,837 - 85,592,624 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4675,501,445 - 75,513,944 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera671,473,300 - 71,488,310 (+)NCBICelera
Cytogenetic Map6q23NCBI
FAM177A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381435,044,907 - 35,083,383 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1435,045,117 - 35,116,630 (+)EnsemblGRCh38hg38GRCh38
GRCh371435,514,113 - 35,552,589 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map14q13.2NCBI
HuRef1415,626,781 - 15,665,252 (+)NCBIHuRef
CHM1_11435,513,864 - 35,552,320 (+)NCBICHM1_1
T2T-CHM13v2.01429,241,864 - 29,280,312 (+)NCBIT2T-CHM13v2.0
Fam177a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391255,171,313 - 55,188,889 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1255,171,254 - 55,188,889 (+)EnsemblGRCm39 Ensembl
GRCm381255,124,435 - 55,142,104 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1255,124,469 - 55,142,104 (+)EnsemblGRCm38mm10GRCm38
MGSCv371256,225,515 - 56,243,091 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361249,662,763 - 49,680,343 (+)NCBIMGSCv36mm8
MGSCv361256,042,658 - 56,060,234 (+)NCBIMGSCv36mm8
Celera1256,419,532 - 56,457,279 (+)NCBICelera
Cytogenetic Map12C1NCBI
cM Map1223.87NCBI
FAM177A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1813,844,565 - 13,862,619 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl813,844,685 - 13,860,889 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha813,641,509 - 13,659,550 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0813,951,498 - 13,969,550 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl813,951,474 - 13,968,204 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1813,653,177 - 13,671,230 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0813,717,477 - 13,735,558 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0814,006,731 - 14,024,846 (+)NCBIUU_Cfam_GSD_1.0
FAM177A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl764,788,077 - 64,808,473 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1764,788,829 - 64,808,640 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2769,618,807 - 69,636,919 (-)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Fam177a1
55 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:13
Count of miRNA genes:13
Interacting mature miRNAs:13
Transcripts:ENSRNOT00000039829
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590290Uminl2Urine mineral level QTL 23.960.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)63878398983783989Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
634307Bp141Blood pressure QTL 1414arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)63523041780230417Rat
634330Pia16Pristane induced arthritis QTL 163.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)645790088104200226Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)672202632115200186Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)658632962103632962Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)657730540104085867Rat
1641904Alcrsp4Alcohol response QTL 4response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)667262953112262953Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
9590140Scort4Serum corticosterone level QTL 414.490.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)63878398983783989Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2301964Bp323Blood pressure QTL 3234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)67222764181132889Rat
9590306Scort18Serum corticosterone level QTL 182.880.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)63878398983783989Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
4889848Pur25Proteinuria QTL 25140.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)65672856290198260Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
6893340Cm77Cardiac mass QTL 770.260.57heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)63330954981132889Rat
70196BpQTLcluster7Blood pressure QTL cluster 76.82arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)672202632117202632Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)671201409116201409Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
1300143Rf14Renal function QTL 142.92renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)63443413777102317Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)661747639106747639Rat
6893332Cm74Cardiac mass QTL 740.40.64heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)657730540104085867Rat

Markers in Region
RH143290  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2672,632,655 - 72,632,756 (+)MAPPERmRatBN7.2
Rnor_6.0676,041,546 - 76,041,646NCBIRnor6.0
Rnor_5.0685,577,891 - 85,577,991UniSTSRnor5.0
RGSC_v3.4675,501,461 - 75,501,561UniSTSRGSC3.4
Celera671,473,960 - 71,474,060UniSTS
RH 3.4 Map5823.9UniSTS
BE118388  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2672,632,896 - 72,633,049 (+)MAPPERmRatBN7.2
Rnor_6.0676,041,787 - 76,041,939NCBIRnor6.0
Rnor_5.0685,578,132 - 85,578,284UniSTSRnor5.0
RGSC_v3.4675,501,702 - 75,501,854UniSTSRGSC3.4
Celera671,474,201 - 71,474,353UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000039829   ⟹   ENSRNOP00000037735
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl676,041,669 - 76,053,759 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102711   ⟹   ENSRNOP00000076613
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl672,632,623 - 72,647,553 (+)Ensembl
RefSeq Acc Id: NM_001399024   ⟹   NP_001385953
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8678,367,780 - 78,382,703 (+)NCBI
mRatBN7.2672,632,628 - 72,647,553 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001385953 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000076613.1
Ensembl Acc Id: ENSRNOP00000037735   ⟸   ENSRNOT00000039829
Ensembl Acc Id: ENSRNOP00000076613   ⟸   ENSRNOT00000102711
RefSeq Acc Id: NP_001385953   ⟸   NM_001399024

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZIM7-F1-model_v2 AlphaFold D3ZIM7 1-208 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2323636 AgrOrtholog
BioCyc Gene G2FUF-37491 BioCyc
Ensembl Genes ENSRNOG00000046391 Ensembl
  ENSRNOG00000064975 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000102711.1 UniProtKB/TrEMBL
InterPro FAM177 UniProtKB/TrEMBL
NCBI Gene 100359558 ENTREZGENE
PANTHER PROTEIN FAM177A1 UniProtKB/TrEMBL
  PTHR31206 UniProtKB/TrEMBL
Pfam FAM177 UniProtKB/TrEMBL
PhenoGen Fam177a1 PhenoGen
RatGTEx ENSRNOG00000046391 RatGTEx
  ENSRNOG00000064975 RatGTEx
UniProt A0A8I5Y661_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Fam177a1  family with sequence similarity 177, member A1  Fam177a1  family with sequence similarity 177, member A1  Data merged from RGD:149736471 737654 PROVISIONAL
2021-08-09 Fam177a1  family with sequence similarity 177, member A1      Symbol and Name status set to provisional 45752 PROVISIONAL
2012-07-19 Fam177a1  family with sequence similarity 177, member A1  LOC100359558  hypothetical protein LOC100359558  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-06 LOC100359558  hypothetical protein LOC100359558      Symbol and Name status set to provisional 70820 PROVISIONAL