Angptl8 (angiopoietin-like 8) - Rat Genome Database

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Gene: Angptl8 (angiopoietin-like 8) Rattus norvegicus
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Symbol: Angptl8
Name: angiopoietin-like 8
RGD ID: 2320121
Description: Predicted to be involved in cellular lipid metabolic process; regulation of lipid metabolic process; and triglyceride homeostasis. Predicted to act upstream of or within cell maturation; fat cell differentiation; and regulation of protein metabolic process. Predicted to be active in extracellular region. Orthologous to human ANGPTL8 (angiopoietin like 8); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: angiopoietin-like protein 8; betatrophin; lipasin; LOC100361444; rCG31799-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Angptl8em1Kyo  
Genetic Models: F344-Angptl8em1Kyo-/- F344-Angptl8em1Kyo+/-
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2820,376,462 - 20,378,488 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl820,376,462 - 20,378,490 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx824,411,953 - 24,413,979 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0822,707,496 - 22,709,522 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0820,606,057 - 20,608,083 (+)NCBIRnor_WKY
Rnor_6.0822,855,495 - 22,858,565 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl822,856,539 - 22,858,565 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0822,910,979 - 22,913,005 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4820,948,070 - 20,950,087 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera821,767,738 - 21,769,764 (+)NCBICelera
Cytogenetic Map8q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. CRISPR/Cas9-mediated Angptl8 knockout suppresses plasma triglyceride concentrations and adiposity in rats. Izumi R, etal., J Lipid Res. 2018 Sep;59(9):1575-1585. doi: 10.1194/jlr.M082099. Epub 2018 Jul 24.
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:22569073   PMID:22809513   PMID:23150577   PMID:24043787   PMID:24353178   PMID:25417115   PMID:25720603   PMID:31578075   PMID:31702044  


Genomics

Comparative Map Data
Angptl8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2820,376,462 - 20,378,488 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl820,376,462 - 20,378,490 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx824,411,953 - 24,413,979 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0822,707,496 - 22,709,522 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0820,606,057 - 20,608,083 (+)NCBIRnor_WKY
Rnor_6.0822,855,495 - 22,858,565 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl822,856,539 - 22,858,565 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0822,910,979 - 22,913,005 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4820,948,070 - 20,950,087 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera821,767,738 - 21,769,764 (+)NCBICelera
Cytogenetic Map8q13NCBI
ANGPTL8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381911,239,619 - 11,241,943 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1911,237,450 - 11,241,943 (+)EnsemblGRCh38hg38GRCh38
GRCh371911,350,295 - 11,352,619 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361911,209,817 - 11,213,619 (+)NCBINCBI36Build 36hg18NCBI36
Celera1911,245,140 - 11,247,464 (+)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef1910,926,369 - 10,928,693 (+)NCBIHuRef
CHM1_11911,351,357 - 11,353,681 (+)NCBICHM1_1
T2T-CHM13v2.01911,366,594 - 11,368,918 (+)NCBIT2T-CHM13v2.0
Angptl8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39921,746,806 - 21,748,643 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl921,746,806 - 21,748,643 (+)EnsemblGRCm39 Ensembl
GRCm38921,835,510 - 21,837,347 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl921,835,510 - 21,837,347 (+)EnsemblGRCm38mm10GRCm38
MGSCv37921,639,954 - 21,641,791 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36921,585,740 - 21,587,757 (+)NCBIMGSCv36mm8
Celera919,105,101 - 19,106,938 (+)NCBICelera
Cytogenetic Map9A3NCBI
Angptl8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554952,205,485 - 2,207,376 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554952,205,424 - 2,207,611 (+)NCBIChiLan1.0ChiLan1.0
ANGPTL8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11911,498,069 - 11,500,400 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1911,498,069 - 11,500,400 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01910,787,457 - 10,790,090 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ANGPTL8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12050,040,383 - 50,043,312 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2050,040,383 - 50,042,031 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2049,913,888 - 49,915,655 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02050,561,284 - 50,563,051 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2050,561,284 - 50,562,932 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12049,771,477 - 49,773,244 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02050,198,362 - 50,200,129 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02050,441,068 - 50,442,835 (-)NCBIUU_Cfam_GSD_1.0
Angptl8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118208,982,926 - 208,984,600 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366591,370,113 - 1,371,769 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049366591,370,115 - 1,371,767 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ANGPTL8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl269,952,581 - 69,954,220 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1269,951,556 - 69,954,223 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ANGPTL8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1610,169,733 - 10,172,433 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl610,170,052 - 10,173,005 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660749,713,854 - 9,716,184 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Angptl8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248283,092,739 - 3,099,120 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248283,092,673 - 3,094,919 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Angptl8
4 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:121
Count of miRNA genes:91
Interacting mature miRNAs:103
Transcripts:ENSRNOT00000015381
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8124597739Rat
2317882Alcrsp24Alcohol response QTL 243.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)8125902202Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8209764047097640Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8209764047097640Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8209764047097640Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8470581049705810Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)8470581049705810Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)8470581049705810Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8767057852670578Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)8768895552688955Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8768895552688955Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)8873663553736635Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)8873663553736635Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)8971222053356647Rat
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat

Markers in Region
BI274505  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2820,378,226 - 20,378,386 (+)MAPPERmRatBN7.2
Rnor_6.0822,858,304 - 22,858,463NCBIRnor6.0
Rnor_5.0822,912,744 - 22,912,903UniSTSRnor5.0
RGSC_v3.4820,949,826 - 20,949,985UniSTSRGSC3.4
Celera821,769,503 - 21,769,662UniSTS
RH 3.4 Map1962.71UniSTS
Cytogenetic Map8q13UniSTS
BI282731  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2820,376,710 - 20,377,030 (+)MAPPERmRatBN7.2
Rnor_6.0822,856,788 - 22,857,107NCBIRnor6.0
Rnor_5.0822,911,228 - 22,911,547UniSTSRnor5.0
RGSC_v3.4820,948,310 - 20,948,629UniSTSRGSC3.4
Celera821,767,987 - 21,768,306UniSTS
Cytogenetic Map8q13UniSTS


Genetic Models
This gene Angptl8 is modified in the following models/strains

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 52 41 3 41 9 4
Low 3 13 5 16 8 8 6 31 23 7 8
Below cutoff 6 3 17 4 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000015381   ⟹   ENSRNOP00000015381
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl820,376,462 - 20,378,488 (+)Ensembl
Rnor_6.0 Ensembl822,856,539 - 22,858,565 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000094372   ⟹   ENSRNOP00000085135
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl820,376,462 - 20,378,490 (+)Ensembl
RefSeq Acc Id: NM_001271710   ⟹   NP_001258639
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2820,376,462 - 20,378,488 (+)NCBI
Rnor_6.0822,856,539 - 22,858,565 (+)NCBI
Rnor_5.0822,910,979 - 22,913,005 (+)NCBI
Celera821,767,738 - 21,769,764 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001258639 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL78268 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001258639   ⟸   NM_001271710
- Peptide Label: precursor
- UniProtKB: D3ZMI0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000015381   ⟸   ENSRNOT00000015381
RefSeq Acc Id: ENSRNOP00000085135   ⟸   ENSRNOT00000094372

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZMI0-F1-model_v2 AlphaFold D3ZMI0 1-198 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695790
Promoter ID:EPDNEW_R6314
Type:single initiation site
Name:Angptl8_1
Description:angiopoietin-like 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0822,856,539 - 22,856,599EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2320121 AgrOrtholog
BioCyc Gene G2FUF-31407 BioCyc
Ensembl Genes ENSRNOG00000011490 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000015381 ENTREZGENE
  ENSRNOP00000015381.6 UniProtKB/TrEMBL
  ENSRNOP00000085135.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015381 ENTREZGENE
  ENSRNOT00000015381.8 UniProtKB/TrEMBL
  ENSRNOT00000094372.1 UniProtKB/TrEMBL
InterPro TD26 UniProtKB/TrEMBL
KEGG Report rno:100361444 UniProtKB/TrEMBL
NCBI Gene 100361444 ENTREZGENE
PANTHER PTHR21463 UniProtKB/TrEMBL
PhenoGen Angptl8 PhenoGen
UniProt A0A8I6A1K9_RAT UniProtKB/TrEMBL
  D3ZMI0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-05 Angptl8  angiopoietin-like 8  LOC100361444  rCG31799-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-05 LOC100361444  rCG31799-like      Symbol and Name status set to provisional 70820 PROVISIONAL