Zfp866 (zinc finger protein 866) - Rat Genome Database

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Pathways
Gene: Zfp866 (zinc finger protein 866) Rattus norvegicus
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Symbol: Zfp866
Name: zinc finger protein 866
RGD ID: 2318899
Description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZNF433 (zinc finger protein 433) and ZNF700 (zinc finger protein 700); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2-amino-2-deoxy-D-glucopyranose.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC100362083; zinc finger protein 20; zinc finger protein 709; zinc finger protein 791; zinc finger-like protein-like
RGD Orthologs
Human
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81619,687,869 - 19,710,407 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1619,702,297 - 19,709,330 (+)EnsemblGRCr8
mRatBN7.21619,653,966 - 19,675,968 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1619,668,258 - 19,675,932 (+)EnsemblmRatBN7.2
Rnor_6.01621,402,938 - 21,424,542 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1621,421,987 - 21,423,741 (+)Ensemblrn6Rnor6.0
Rnor_5.01621,306,769 - 21,338,531 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41620,129,174 - 20,139,887 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1619,843,015 - 19,895,218 (+)NCBICelera
Cytogenetic Map16p14NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IBA,IEA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Comparative Map Data
Zfp866
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81619,687,869 - 19,710,407 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1619,702,297 - 19,709,330 (+)EnsemblGRCr8
mRatBN7.21619,653,966 - 19,675,968 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1619,668,258 - 19,675,932 (+)EnsemblmRatBN7.2
Rnor_6.01621,402,938 - 21,424,542 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1621,421,987 - 21,423,741 (+)Ensemblrn6Rnor6.0
Rnor_5.01621,306,769 - 21,338,531 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41620,129,174 - 20,139,887 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1619,843,015 - 19,895,218 (+)NCBICelera
Cytogenetic Map16p14NCBI
ZNF700
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381911,925,107 - 11,950,763 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1911,925,068 - 11,950,773 (+)Ensemblhg38GRCh38
GRCh371912,035,922 - 12,061,578 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361911,896,900 - 11,922,578 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1911,930,275 - 11,955,954 (+)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef1911,610,790 - 11,636,048 (+)NCBIHuRef
CHM1_11912,035,716 - 12,061,423 (+)NCBICHM1_1
T2T-CHM13v2.01912,053,315 - 12,078,973 (+)NCBIT2T-CHM13v2.0
Zfp997
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391366,258,188 - 66,271,523 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1366,261,294 - 66,271,953 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381366,110,374 - 66,123,709 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1366,113,480 - 66,122,836 (+)Ensemblmm10GRCm38
MGSCv371366,214,389 - 66,266,530 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361366,873,753 - 66,884,726 (+)NCBIMGSCv36mm8
Cytogenetic Map13B3NCBI
cM Map1334.51NCBI

Variants

.
Variants in Zfp866
161 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:88
Count of miRNA genes:79
Interacting mature miRNAs:80
Transcripts:ENSRNOT00000034415, ENSRNOT00000034446
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549842Bp248Blood pressure QTL 2480.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1638712345387123Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133425095Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139568015Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16423421253708481Rat
631517Scl9Serum cholesterol level QTL 93.3blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)161574800625801629Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16474422249744222Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16126734272Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126734272Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16435482249354822Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)1638712345387123Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16423421249757901Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16423421266955197Rat
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)161627818427244292Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139568015Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683908666195506Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338679049757901Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338679026128267Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683908666195506Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683908666195506Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126734272Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161773081872536785Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683908652786090Rat
2301406Kidm39Kidney mass QTL 390.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)161590580260905802Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683908666195506Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16330168348301683Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 87 59 6 350 187 11 142 80 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000034415   ⟹   ENSRNOP00000029668
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1619,702,297 - 19,709,330 (+)Ensembl
mRatBN7.2 Ensembl1619,668,258 - 19,675,932 (+)Ensembl
Rnor_6.0 Ensembl1621,421,987 - 21,423,741 (+)Ensembl
RefSeq Acc Id: NM_001408763   ⟹   NP_001395692
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81619,702,302 - 19,709,636 (+)NCBI
mRatBN7.21619,668,399 - 19,675,733 (+)NCBI
RefSeq Acc Id: XM_017600344   ⟹   XP_017455833
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81619,687,869 - 19,710,407 (+)NCBI
mRatBN7.21619,653,966 - 19,675,968 (+)NCBI
Rnor_6.01621,402,938 - 21,424,542 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001395692 (Get FASTA)   NCBI Sequence Viewer  
  XP_017455833 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI58786 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000029668
  ENSRNOP00000029668.6
RefSeq Acc Id: XP_017455833   ⟸   XM_017600344
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000029668   ⟸   ENSRNOT00000034415
RefSeq Acc Id: NP_001395692   ⟸   NM_001408763
- UniProtKB: F1LU95 (UniProtKB/TrEMBL)
Protein Domains
C2H2-type   KRAB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LU95-F1-model_v2 AlphaFold F1LU95 1-382 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2318899 AgrOrtholog
BioCyc Gene G2FUF-11736 BioCyc
Ensembl Genes ENSRNOG00000042580 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000034415 ENTREZGENE
  ENSRNOT00000034415.7 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.140 UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/TrEMBL
InterPro KRAB_dom_sf UniProtKB/TrEMBL
  Krueppel-associated_box UniProtKB/TrEMBL
  Znf_C2H2-type UniProtKB/TrEMBL
  Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
NCBI Gene 100362083 ENTREZGENE
PANTHER RIKEN CDNA 6720489N17 GENE-RELATED UniProtKB/TrEMBL
  ZNF44 PROTEIN UniProtKB/TrEMBL
Pfam KRAB UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/TrEMBL
PhenoGen Zfp866 PhenoGen
PROSITE KRAB UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000042580 RatGTEx
SMART KRAB UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP Krueppel-associated_box UniProtKB/TrEMBL
  SSF57667 UniProtKB/TrEMBL
UniProt F1LU95 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-08-27 Zfp866  zinc finger protein 866  LOC100362083  zinc finger-like protein-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-05 LOC100362083  zinc finger-like protein-like      Symbol and Name status set to provisional 70820 PROVISIONAL